VBDCMM

• We develop Bayesian version of double chain markov model using variational inference technique.
• The method is used to analyze H-DNA dynamics which shows dynamic disorder due to their complex free energy landscape.
• The method can be applied to any one dimensional time traces.
• The result is published in PLoS Computational Biology journal.
  • Wonseok Hwang et al, Decoding Single Molecule Time Traces with Dynamic Disorder, PLoS Comp. Biol. 2016