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From microarray results to network

The aim of this repo is create protein interaction network for gene expression data in maize. The starting point is a mapping between oligo probes (abbreviated MZ) to maize genes (NAM v5 assembly, dubbed NAM). The code for MZ-NAM mapping is not included here.

The primary ID type in STRING v 12 is UniProt (abbreviated UP here) and mapping to AGPv4 but no to NAM is included. To avoid arbitraly choices during matching NAMs to V4 and UPs and selecting best mapping I will use protein-mapping facility at STRING12 website.

List of files

Outdated

bestNAMforV3.sh - selecting best mapping of oligo-probe to NAMv5 genome, deprecated

sieci-orto-ala.sh - network construction based on orthology data

Current

Probe mapping

probe-mapping.sh - main file describing microarray probe mapping. This file uses:

  • skrypt_v2.sh - script for selecting the longest alignment for each probe
  • komendy_skryptu, komendy_skryptu40, komendy_skryptu50 - commands for pasting to terminal

spojne-mz-ala.sh - selecting best oligo-probe - NAMv5 mapping. Uses duplik030223.r

duplik030223.r - some commands to compute averages for probes with multiple values

Variant detection and further analyses

map-pl.sh - mapping of resequencing data. Here also variant-calling is described.

notatki.sh - some notes and links concerning analysis

  • selection of interesting variants

Network construction

annotation.sh - functional annotation of genes, direct from NAM and translated from AGPv4

new network-map-string.sh - network based on mapping of proteins in STRING 12

string12-network.sh - network based on STRING 12 release and UniProt IDs

score-hist.r - histogram for "Combined score"

average-UPs.r - R script for expression averaging (averaging for different NAMs mapped to one UP)

  • construction of STRING network for all mapped probes

Side project -gibberellin network

ga-network25.sh - network from RT-qPCR results

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Network for microarray results using STRING

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