A comprehensive strategy guide for Mewgenics, the cat-breeding roguelite by Edmund McMillen (creator of The Binding of Isaac, Super Meat Boy).
View the guide — hosted on GitHub Pages
Mewgenics combines Mendelian genetics with turn-based tactical combat across procedurally generated runs. This guide covers every layer of the game: breeding and genetics mechanics, team composition strategy, affliction management, meta-progression systems, and full main-quest walkthroughs including secret content and the True Ending.
- Genetics & Breeding Calculator — Predict offspring stat ranges from two parents. Computes inbreeding coefficients and inheritance probabilities based on room Stimulation breakpoints.
- Team Builder — Four-slot party builder with attribute-scored radar charts, brute-force auto-pick for optimal combinations, class-by-zone matchup ratings, synergy detection, and item set recommendations.
- Afflictions Encyclopedia — Reference tables for diseases, disorders, birth defects, and parasites. Curability, combat applications, and build considerations.
- Meta-Progression Guide — NPC upgrade trees, pipe system, Butch inventory, Tink genetics display, Dr. Beanies inventions, and optimal priority ordering.
- Main Quest Walkthrough — Acts 1-3, Five Wardens, Genetic Core boss phases, secret sixth boss, and True Ending requirements.