Skip to content

Correct receptor expression references from ct1 to ct2 #1

New issue

Have a question about this project? Sign up for a free GitHub account to open an issue and contact its maintainers and the community.

Sign up for GitHub

By clicking “Sign up for GitHub”, you agree to our terms of service and privacy statement. We’ll occasionally send you account related emails.

Already on GitHub? Sign in to your account

Open
sahil-sahni wants to merge 1 commit into
base: main
Choose a base branch
from
Open

Correct receptor expression references from ct1 to ct2 #1

Changes from all commits
Commits
Show all changes
1 commit
Select commit
File filter

Filter by extension

Filter by extension
Conversations
Failed to load comments.
Loading
Jump to
Jump to file
Failed to load files.
Loading
Diff view
Diff view
15 changes: 8 additions & 7 deletions R/SOCIAL.R
View file
Open in desktop
Original file line number Diff line number Diff line change
@@ -1,5 +1,6 @@
#IRIS package
#Sahil Sahni & Kun Wang 07/31/24
#Sahil Sahni & Kun Wang 07/31/24;
#Corrected by Sahil Sahni 03/05/26;

## SOCIAL

Expand Down Expand Up @@ -81,9 +82,9 @@ calculate_interaction_score <- function(expr,ct_map, pairs, n_iterations = 100){
else
ligand_exp = as.numeric(summary_expr[g1,ct1])
if(length(g2) > 1)
receptor_exp = min(as.numeric(summary_expr[g2,ct1]))
receptor_exp = min(as.numeric(summary_expr[g2,ct2])) # 3/5/26: correct ct1 to ct2
else
receptor_exp = as.numeric(summary_expr[g2,ct1])
receptor_exp = as.numeric(summary_expr[g2,ct2]) # 3/5/26: correct ct1 to ct2

#interaction score
sc = ligand_exp*receptor_exp
Expand Down Expand Up @@ -119,9 +120,9 @@ calculate_interaction_score <- function(expr,ct_map, pairs, n_iterations = 100){
score = c()
receptor_exp = NULL
if(length(g2) > 1)
receptor_exp = min(as.numeric(summary_expr[g2,ct1]))
receptor_exp = min(as.numeric(summary_expr[g2,ct2])) # 3/5/26: correct ct1 to ct2
else
receptor_exp = as.numeric(summary_expr[g2,ct1])
receptor_exp = as.numeric(summary_expr[g2,ct2]) # 3/5/26: correct ct1 to ct2

#receptor expression
sc = receptor_exp
Expand Down Expand Up @@ -171,9 +172,9 @@ calculate_interaction_score <- function(expr,ct_map, pairs, n_iterations = 100){
else
ligand_exp = as.numeric(summary_expr[g1,ct1])
if(length(g2) > 1)
receptor_exp = min(as.numeric(summary_expr[g2,ct1]))
receptor_exp = min(as.numeric(summary_expr[g2,ct2])) # 3/5/26: correct ct1 to ct2
else
receptor_exp = as.numeric(summary_expr[g2,ct1])
receptor_exp = as.numeric(summary_expr[g2,ct2]) # 3/5/26: correct ct1 to ct2

#null score
sc = ligand_exp*receptor_exp
Expand Down