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Correct receptor expression references from ct1 to ct2 #1

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Correct receptor expression references from ct1 to ct2 #1

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15 changes: 8 additions & 7 deletions 3-SOCIAL & SPECIAL/SOCIAL & SPECIAL Function/SOCIAL_SPECIAL.R
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Original file line number Diff line number Diff line change
@@ -1,4 +1,5 @@
## SOCIAL & SPECIAL
## Correction on 03/05/26
library(tidyverse)
library(Matrix)
library(parallel)
Expand Down Expand Up @@ -101,9 +102,9 @@ SOCIAL.calculate_interaction_score <- function(expr,ct_map, pairs, n_iterations
else
ligand_exp = as.numeric(summary_expr[g1,ct1])
if(length(g2) > 1)
receptor_exp = min(as.numeric(summary_expr[g2,ct1]))
receptor_exp = min(as.numeric(summary_expr[g2,ct2])) # 3/5/26: corrected ct1 to ct2
else
receptor_exp = as.numeric(summary_expr[g2,ct1])
receptor_exp = as.numeric(summary_expr[g2,ct2]) # 3/5/26: corrected ct1 to ct2

#interaction score
sc = ligand_exp*receptor_exp
Expand Down Expand Up @@ -139,9 +140,9 @@ SOCIAL.calculate_interaction_score <- function(expr,ct_map, pairs, n_iterations
score = c()
receptor_exp = NULL
if(length(g2) > 1)
receptor_exp = min(as.numeric(summary_expr[g2,ct1]))
receptor_exp = min(as.numeric(summary_expr[g2,ct2])) # 3/5/26: corrected ct1 to ct2
else
receptor_exp = as.numeric(summary_expr[g2,ct1])
receptor_exp = as.numeric(summary_expr[g2,ct2]) # 3/5/26: corrected ct1 to ct2

#receptor expression
sc = receptor_exp
Expand Down Expand Up @@ -191,9 +192,9 @@ SOCIAL.calculate_interaction_score <- function(expr,ct_map, pairs, n_iterations
else
ligand_exp = as.numeric(summary_expr[g1,ct1])
if(length(g2) > 1)
receptor_exp = min(as.numeric(summary_expr[g2,ct1]))
receptor_exp = min(as.numeric(summary_expr[g2,ct2])) # 3/5/26: corrected ct1 to ct2
else
receptor_exp = as.numeric(summary_expr[g2,ct1])
receptor_exp = as.numeric(summary_expr[g2,ct2]) # 3/5/26: corrected ct1 to ct2

#null score
sc = ligand_exp*receptor_exp
Expand Down Expand Up @@ -747,4 +748,4 @@ run_special_rslurm <- function(index, path_input, path_special, name, n_iteratio
#run SPECIAL step 1 and 2
results = SPECIAL(expr, pairs, loc, name, n_iterations, path_special, distance, platform, puck_diameter)
return(results)
}
}