feat(anx+sleep): 11 anxiolytic + hypnotic drug cards (batch 4) - #9
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ANXIOLYTICS (7, category Тревожные расстройства): - drug_diazepam — long-acting BDZ (Ukrainian standard for AW), CYP3A4 - drug_lorazepam — intermediate BDZ, predictable IM, glucuronidation (hepatic-safe), catatonia first-line - drug_alprazolam — short-acting, panic FDA, ⚠ severe interdose+misuse (Bazire warning) - drug_clonazepam — intermediate-long, panic+seizures, REM behavior disorder first-line - drug_buspirone — 5-HT1A partial agonist, NO sedation/dependence/withdrawal, GAD - drug_pregabalin — α2δ ligand, predictable PK, GAD/DPN/fibromyalgia, ⚠ Schedule V (misuse) - drug_gabapentin — α2δ ligand, saturable absorption, AW alternative (Myrick 2009 RCT) HYPNOTICS (4, category Расстройства сна): - drug_zolpidem — α1-selective Z-drug, sleep onset, ⚠ FDA black box (complex sleep behaviors), women dose ÷2 - drug_zopiclone — cyclopyrrolone Z-drug, broader receptor profile, sleep maintenance, bitter taste 35% - drug_trazodone — SARI, low-dose hypnotic + standard-dose AD, ⚠ priapism, geriatric-friendly - drug_suvorexant — first DORA (orexin antagonist), novel non-GABA mechanism, less dependence Stats: 144 → 155 entries (+11), 543 → 606 citations.
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Fourth batch: 7 anxiolytics (BDZs + non-BDZ alternatives) + 4 hypnotics (Z-drugs + trazodone + suvorexant). Each entry covers mechanism, dosing, PK, side effects, interactions, special populations, and 'when to choose vs avoid' guidance. Citations 543 → 606.