feat(ad): 11 antidepressant drug cards (batch 3/n) — SSRI/atypical/SNRI - #8
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NEUROP-based AD drug cards (matrix format ~30-50 lines, 6+ sources each). SSRIs (5): - drug_sertraline — FDA-approved PTSD, cardiac-safe (SADHART), pregnancy OK - drug_escitalopram — top-2 efficacy (Cipriani 2018), QTc dose-dep, max 20 mg - drug_paroxetine — discontinuation severe, ⚠ pregnancy class D, CYP2D6 inhibitor (tamoxifen contraindicated), FDA-approved PTSD - drug_fluoxetine — longest T½ (4-6d parent + 7-15d norfluoxetine), self-tapers, FDA-approved adolescents 8+, Symbyax for bipolar dep - drug_fluvoxamine — FDA OCD, strongest CYP1A2/2C19 inhibitor (clozapine dose ÷3), highest GI burden Atypical (3): - drug_mirtazapine — NaSSA, dose-paradox (15 mg > 30 mg sedative), no sexual SE, no discontinuation, +appetite (great for elderly/cachexia) - drug_bupropion — NDRI, no sexual SE, no weight gain, activating, smoking cessation (Zyban), ⚠ seizure threshold (BN/AN contraindicated) - drug_vortioxetine — multimodal, FDA-approved for cognitive function in MDD (only AD), minimal sexual SE - drug_agomelatine — MT1/MT2 + 5-HT2C, EU only, ⚠ hepatotoxicity (mandatory ALT/AST baseline+3/6/12/24wk), no sexual/weight/discontinuation SNRIs (2): - drug_venlafaxine — dose-dependent (≤150 mg = SSRI; >150 = SNRI), severe discontinuation, ⚠ HTN dose-dep, ⚠ highest bipolar induction risk - drug_duloxetine — balanced SNRI, FDA-approved chronic pain/fibromyalgia/DPN/OA, ⚠ hepatic with alcohol (black box) Stats: 133 → 144 entries, 477 → 543 citations.
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Third batch of NEUROP-based drug cards: 5 SSRI + 3 atypical AD + 2 SNRI + bupropion (NDRI). Each entry includes pharmacology/PK/dose/SE/interactions/special-populations + 'when to choose / when to avoid' guidance. Citations 477 → 543.