Diffusion_Calculator

Comprehensive IVIM calculator tool

Diffusion Calculator is a comprehensive, open-source software suite designed for the quantitative analysis of renal Intravoxel Incoherent Motion (IVIM) MRI data.

This app introduces AI-powered segmentation (MedSAM), a standalone executable for easy installation, and rigorous clinical validation against industry standards (Siemens Syngo.via).

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Key Features

• Verified Accuracy: Benchmarked against FDA-approved Siemens Syngo.via. Demonstrated >0.90 ICC.
• AI-Assisted Segmentation: Integrates MedSAM to automate kidney localization, replacing tedious manual ROI drawing.
• Artifact Correction: Features a novel "Safe-Zone Adaptive Thresholding" algorithm to eliminate cortex/medulla edge artifacts.
• Universal Compatibility: Supports DICOM datasets from major vendors (Siemens, GE, Philips) with automated b-value parsing.
• Advanced Fitting Models: Mono-exponential (ADC), Bi-exponential (IVIM), Segmented, Bayesian, and Tri-exponential.
• Universal Export: Exports parameter maps as NIfTI (.nii) and Excel (.xlsx).

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Downloads & Installation

We provide a standalone version for clinicians and source code for developers.

1. Standalone Executable (No MATLAB Required)

Recommended for clinical users. The standalone package includes the compiled application and necessary runtime installers.

• Download Installer:

Installation Steps:

1. Download and unzip the installer package.
2. Run Installer.exe or Web_Installer.exe.
3. Follow the prompts (it will automatically download MATLAB Runtime if you run Web_Installer.exe ).
4. Launch the application from your desktop.

IMPORTANT INSTALLATION NOTE:

If the software fails to load data on the very first launch:

1. Close the application.
2. Re-open it.

This is a known behavior of MATLAB Runtime initialization on Windows and is resolved after the first restart.

2. Example Dataset

To test the software, you can download our anonymized validation dataset (DICOM):

• Download Data:

3. Source Code (For Developers)

Requires MATLAB R2024b + Toolboxes.

• Clone this repository or download the source archive

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📺 Video Tutorial

For a comprehensive walkthrough of the workflow (Loading, Registration, Segmentation, and Analysis), please download and watch our tutorials:

• Watch Tutorial:

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🧮 Mathematical Models

The software implements non-linear least squares fitting (Levenberg-Marquardt) for the following models:

1. Bi-Exponential IVIM Model

$$\frac{S(b)}{S_0} = f \cdot e^{-b D^*} + (1-f) \cdot e^{-b D}$$

2. Mono-Exponential (ADC)

$$S(b) = S_0 \cdot e^{-b \cdot ADC}$$

3. Tri-Exponential Model

$$\frac{S(b)}{S_0} = f_{fast} e^{-b D_{fast}} + f_{inter} e^{-b D_{inter}} + f_{slow} e^{-b D_{slow}}$$

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License: MIT License.
Contact: [atakani@baskent.edu.tr]