diff --git a/sgl_deep_gemm/__init__.py b/sgl_deep_gemm/__init__.py
index c3e73931e4..45bd116958 100644
--- a/sgl_deep_gemm/__init__.py
+++ b/sgl_deep_gemm/__init__.py
@@ -9,6 +9,9 @@
 
 from .cuda_helpers import find_cuda_home, get_cuda_arch
 
+_SM90_TINY_WEIGHT_SCALE_THRESHOLD = 1.0e-12
+_SM90_PRUNED_WEIGHT_SCALE = 1.0e-5
+
 if TYPE_CHECKING:
     from tvm_ffi.module import Module
 
@@ -374,11 +377,65 @@ def get_symm_buffer_for_mega_moe(group,
     )
 
 
+def _sanitize_sm90_fp8_weight_blocks(
+    weight: torch.Tensor,
+    scale: torch.Tensor,
+    *,
+    threshold: float = _SM90_TINY_WEIGHT_SCALE_THRESHOLD,
+) -> Tuple[torch.Tensor, torch.Tensor]:
+    """Make effectively pruned FP8 blocks safe for SM90 MegaMoE."""
+    if weight.ndim != 3 or scale.ndim != 3:
+        raise ValueError(
+            f"SM90 MegaMoE expects rank-3 weights/scales, got "
+            f"weight={tuple(weight.shape)}, scale={tuple(scale.shape)}"
+        )
+    num_experts, n, k = weight.shape
+    expected_scale_shape = (num_experts, n // 128, k // 128)
+    if n % 128 != 0 or k % 128 != 0:
+        raise ValueError(f"SM90 FP8 weight shape must be 128-aligned, got {(n, k)}")
+    if tuple(scale.shape) != expected_scale_shape:
+        raise ValueError(
+            f"SM90 FP8 scale shape mismatch: got {tuple(scale.shape)}, "
+            f"expected {expected_scale_shape}"
+        )
+    if weight.dtype not in (torch.float8_e4m3fn, torch.float8_e4m3fnuz):
+        raise ValueError(f"SM90 MegaMoE expects FP8 weights, got {weight.dtype}")
+
+    tiny = scale.abs() < threshold
+    if not bool(tiny.any()):
+        return weight, scale
+
+    sanitized_weight = weight.clone()
+    sanitized_scale = scale.clone()
+    weight_blocks = sanitized_weight.view(
+        num_experts,
+        n // 128,
+        128,
+        k // 128,
+        128,
+    )
+    weight_blocks.view(torch.uint8).masked_fill_(
+        tiny[:, :, None, :, None],
+        0,
+    )
+    for expert in tiny.any(dim=(1, 2)).nonzero(as_tuple=False).flatten().tolist():
+        normal_scales = sanitized_scale[expert][~tiny[expert]]
+        replacement = (
+            normal_scales.median()
+            if normal_scales.numel()
+            else sanitized_scale.new_tensor(_SM90_PRUNED_WEIGHT_SCALE)
+        )
+        sanitized_scale[expert].masked_fill_(tiny[expert], replacement)
+    return sanitized_weight, sanitized_scale
+
+
 def transform_weights_for_mega_moe_sm90(
     l1_weights: Tuple[torch.Tensor, torch.Tensor],
     l2_weights: Tuple[torch.Tensor, torch.Tensor]
 ) -> Tuple[Tuple[torch.Tensor, torch.Tensor], Tuple[torch.Tensor, torch.Tensor]]:
     l1_fp8, l1_sf = l1_weights
+    l1_fp8, l1_sf = _sanitize_sm90_fp8_weight_blocks(l1_fp8, l1_sf)
+    l2_fp8, l2_sf = _sanitize_sm90_fp8_weight_blocks(*l2_weights)
 
     def _interleave_one(t, gran: int = 8) -> torch.Tensor:
         g, n, *rest = t.shape
@@ -387,7 +444,7 @@ def _interleave_one(t, gran: int = 8) -> torch.Tensor:
         up = t[:, half:].reshape(g, half // gran, gran, *rest)
         return torch.empty_like(t).copy_(torch.stack([gate, up], dim=2).reshape(g, n, *rest))
 
-    return (_interleave_one(l1_fp8), l1_sf), l2_weights
+    return (_interleave_one(l1_fp8), l1_sf), (l2_fp8, l2_sf)
 
 
 def fp8_mega_moe(y: torch.Tensor,
diff --git a/sgl_deep_gemm/run_tests.sh b/sgl_deep_gemm/run_tests.sh
index 86dba4b4c9..dcc3536b42 100755
--- a/sgl_deep_gemm/run_tests.sh
+++ b/sgl_deep_gemm/run_tests.sh
@@ -159,6 +159,7 @@ MEGA_MOE_BLACKWELL=(
 )
 MEGA_MOE_HOPPER=(
   test_mega_moe_hopper.py
+  test_mega_moe_sm90_weight_transform.py
   test_mega_moe_pre_dispatch_sm90.py
 )
 MEGA_MOE_ALL=(
diff --git a/sgl_deep_gemm/tests/test_mega_moe_sm90_weight_transform.py b/sgl_deep_gemm/tests/test_mega_moe_sm90_weight_transform.py
new file mode 100644
index 0000000000..a9bf36f049
--- /dev/null
+++ b/sgl_deep_gemm/tests/test_mega_moe_sm90_weight_transform.py
@@ -0,0 +1,51 @@
+"""Regression test for SM90 MegaMoE FP8 weight-block sanitization."""
+
+import argparse
+
+import torch
+
+import deep_gemm
+
+
+def main() -> None:
+    parser = argparse.ArgumentParser()
+    # Keep the common test-runner interface; this test is intentionally single-rank.
+    parser.add_argument("--num-processes", type=int, default=1)
+    parser.parse_args()
+
+    if not torch.cuda.is_available():
+        print("SKIP: CUDA is not available")
+        return
+    if torch.cuda.get_device_capability()[0] != 9:
+        print("SKIP: requires an SM90 CUDA device")
+        return
+
+    l1_weight = torch.full(
+        (1, 256, 128), 7, dtype=torch.float8_e4m3fn, device="cuda"
+    )
+    l2_weight = torch.full(
+        (1, 128, 128), 7, dtype=torch.float8_e4m3fn, device="cuda"
+    )
+    l1_scale = torch.full((1, 2, 1), 1.0e-20, dtype=torch.float32, device="cuda")
+    l2_scale = torch.full((1, 1, 1), 1.0e-20, dtype=torch.float32, device="cuda")
+
+    transformed_l1, transformed_l2 = deep_gemm.transform_weights_for_mega_moe_sm90(
+        (l1_weight, l1_scale), (l2_weight, l2_scale)
+    )
+    transformed_l1_weight, transformed_l1_scale = transformed_l1
+    transformed_l2_weight, transformed_l2_scale = transformed_l2
+
+    assert torch.count_nonzero(transformed_l1_weight).item() == 0
+    assert torch.count_nonzero(transformed_l2_weight).item() == 0
+    assert torch.isfinite(transformed_l1_scale).all()
+    assert torch.isfinite(transformed_l2_scale).all()
+    assert torch.all(transformed_l1_scale >= 1.0e-12)
+    assert torch.all(transformed_l2_scale >= 1.0e-12)
+    # The input tensors are caller-owned and must remain unchanged.
+    assert torch.count_nonzero(l1_weight).item() == l1_weight.numel()
+    assert torch.count_nonzero(l2_weight).item() == l2_weight.numel()
+    print("PASS: tiny SM90 MegaMoE weight blocks were sanitized")
+
+
+if __name__ == "__main__":
+    main()