diff --git a/inst/modeldb/therapeuticArea/oncology_sdm_lobo_2002.R b/inst/modeldb/therapeuticArea/oncology_sdm_lobo_2002.R index 439c26693..b581d6f97 100644 --- a/inst/modeldb/therapeuticArea/oncology_sdm_lobo_2002.R +++ b/inst/modeldb/therapeuticArea/oncology_sdm_lobo_2002.R @@ -23,12 +23,15 @@ oncology_sdm_lobo_2002 <- function() { drugEffectTumorVol <- kmax*Cc/(ec50 + Cc) - tumorVol(0) <- tumorVol0 d/dt(tumorVol) <- kng*tumorVol - transit4*tumorVol d/dt(transit1) <- (drugEffectTumorVol - transit1)/tau d/dt(transit2) <- (transit1 - transit2)/tau d/dt(transit3) <- (transit2 - transit3)/tau d/dt(transit4) <- (transit3 - transit4)/tau + + tumorVol(0) <- tumorVol0 + + tumorVol ~ prop(tumorVolpropSd) + add(tumorVoladdSd) }) } diff --git a/inst/modeldb/therapeuticArea/oncology_xenograft_simeoni_2004.R b/inst/modeldb/therapeuticArea/oncology_xenograft_simeoni_2004.R index e3dc25c87..a9ea92232 100644 --- a/inst/modeldb/therapeuticArea/oncology_xenograft_simeoni_2004.R +++ b/inst/modeldb/therapeuticArea/oncology_xenograft_simeoni_2004.R @@ -17,6 +17,10 @@ oncology_xenograft_simeoni_2004 <- function() { tumorVoladdSd <- 30 ; label("Additive residual error (tumor volume)") }) model({ + cmt(cyclingCells) + cmt(damagedCells1) + cmt(damagedCells2) + cmt(damagedCells3) damageTransit <- exp(ldamageTransit) drugSlope <- exp(ldrugSlope) tumorExpGrowth <- exp(ltumorExpGrowth) diff --git a/man/modeldb.Rd b/man/modeldb.Rd index 96c7a6d5a..e6e48fc8a 100644 --- a/man/modeldb.Rd +++ b/man/modeldb.Rd @@ -5,7 +5,18 @@ \alias{modeldb} \title{Model library for nlmixr2} \format{ -An object of class \code{data.frame} with 17 rows and 9 columns. +A data frame with 17 rows and 9 columns +\describe{ + \item{name}{Model name that can be used to extract the model from the model library} + \item{description}{Model description in free from text; in model itself} + \item{parameters}{A comma separated string listing either the parameter in the model defined by population/individual effects or a population effect parameter} + \item{DV}{The definition of the dependent variable(s)} + \item{linCmt}{Logical flag indicating if solved models are used (TRUE) or not (FALSE)} + \item{algebraic}{Logical flag indicating if the model is purely algebraic: TRUE no linCmt() and no ODEs; FALSE otherwise} + \item{dosing}{A comma separated string of identified dosing compartments} + \item{depends}{A comma separated string of objects the model depends on} + \item{filename}{Filename of the model. By default these are installed in the model library and read on demand} +} } \usage{ modeldb