From 256e1bfcd8b43ac3a9d1ef98bdb7b3b3e5f85f7c Mon Sep 17 00:00:00 2001
From: mattfidler <matthew.fidler@gmail.com>
Date: Fri, 10 Jul 2026 10:00:34 -0500
Subject: [PATCH] data: add neonatal_wt (neonatal weight progression) dataset

Longitudinal neonatal body weight for 189 neonates (1120 obs) with 5 covariates
(Sex, DelM, GA, Mage, Para2), the second case study in Rohleff et al. (2025) on
VAE-based NLME modeling. No dosing (turnover growth model with an estimated
initial weight), so every record is an observation (EVID=0).

Co-Authored-By: Claude Opus 4.8 <noreply@anthropic.com>
Claude-Session: https://claude.ai/code/session_01CWzfXji5F2nmr34AUa7Ntu
---
 DESCRIPTION            |   2 +-
 R/data_neonatal_wt.R   |  26 +++++++++++++++++
 data/neonatal_wt.rda   | Bin 0 -> 10868 bytes
 man/Bolus_1CPT.Rd      |  13 +++++----
 man/Bolus_1CPTMM.Rd    |  13 +++++----
 man/Bolus_2CPT.Rd      |  13 +++++----
 man/Bolus_2CPTMM.Rd    |  13 +++++----
 man/Infusion_1CPT.Rd   |  13 +++++----
 man/Infusion_1CPTMM.Rd |  13 +++++----
 man/Infusion_2CPT.Rd   |  13 +++++----
 man/Infusion_2CPTMM.Rd |  13 +++++----
 man/Oral_1CPT.Rd       |  13 +++++----
 man/Oral_1CPTMM.Rd     |  13 +++++----
 man/Oral_2CPT.Rd       |  13 +++++----
 man/Oral_2CPTMM.Rd     |  13 +++++----
 man/Wang2007.Rd        |  15 +++++-----
 man/mavoglurant.Rd     |  15 +++++-----
 man/neonatal_wt.Rd     |  62 +++++++++++++++++++++++++++++++++++++++++
 man/nimoData.Rd        |  15 +++++-----
 man/nmtest.Rd          |  15 +++++-----
 man/pheno_sd.Rd        |  15 +++++-----
 man/rats.Rd            |  15 +++++-----
 man/theo_md.Rd         |  15 +++++-----
 man/theo_sd.Rd         |  15 +++++-----
 man/warfarin.Rd        |  15 +++++-----
 man/wbcSim.Rd          |  15 +++++-----
 26 files changed, 253 insertions(+), 143 deletions(-)
 create mode 100644 R/data_neonatal_wt.R
 create mode 100644 data/neonatal_wt.rda
 create mode 100644 man/neonatal_wt.Rd

diff --git a/DESCRIPTION b/DESCRIPTION
index af7fbd4..480ba92 100644
--- a/DESCRIPTION
+++ b/DESCRIPTION
@@ -30,10 +30,10 @@ Description: Datasets for 'nlmixr2' and 'rxode2'. 'nlmixr2' is used for fitting
 License: GPL (>= 3)
 Encoding: UTF-8
 Roxygen: list(markdown = TRUE)
-RoxygenNote: 7.2.3
 Depends:
     R (>= 2.10)
 LazyData: true
 BugReports: https://github.com/nlmixr2/nlmixr2data/issues/
 URL: https://nlmixr2.github.io/nlmixr2data/,
     https://github.com/nlmixr2/nlmixr2data/
+Config/roxygen2/version: 8.0.0
diff --git a/R/data_neonatal_wt.R b/R/data_neonatal_wt.R
new file mode 100644
index 0000000..aff1373
--- /dev/null
+++ b/R/data_neonatal_wt.R
@@ -0,0 +1,26 @@
+#' Neonatal weight progression data
+#'
+#' Longitudinal body-weight measurements for a cohort of neonates over roughly
+#' the first week of life, used as the second case study (neonatal weight
+#' progression) in Rohleff et al. (2025) on VAE-based nonlinear mixed-effects
+#' modeling. There is no dosing; body weight follows a turnover (zero-order
+#' production, first-order elimination) growth model whose initial weight is an
+#' estimated parameter, so every record is an observation (\code{EVID = 0}).
+#'
+#' @format A data frame with 1120 rows by 9 columns
+#'
+#' \describe{
+#'   \item{ID}{Subject ID (189 neonates)}
+#'   \item{TIME}{Time since birth (days)}
+#'   \item{DV}{Dependent Variable, body weight (g)}
+#'   \item{EVID}{rxode2/nlmixr2 event ID (0 = observation; no dosing)}
+#'   \item{Sex}{Sex, 0/1}
+#'   \item{DelM}{Delivery mode, 0/1}
+#'   \item{GA}{Gestational age at birth (weeks)}
+#'   \item{Mage}{Maternal age (years)}
+#'   \item{Para2}{Parity indicator, 0/1}
+#' }
+#'
+#' @source Rohleff et al. (2025), CPT: Pharmacometrics & Systems Pharmacology
+#' @family nlmixr2 datasets
+"neonatal_wt"
diff --git a/data/neonatal_wt.rda b/data/neonatal_wt.rda
new file mode 100644
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HcmV?d00001

diff --git a/man/Bolus_1CPT.Rd b/man/Bolus_1CPT.Rd
index f034100..edd4d1a 100644
--- a/man/Bolus_1CPT.Rd
+++ b/man/Bolus_1CPT.Rd
@@ -57,20 +57,21 @@ samples in 24 hours per subject, using a first-order absorption,
 1-compartment disposition, linear elimination model.
 }
 \seealso{
-Other nlmixr2 datasets: 
+Other nlmixr2 datasets:
 \code{\link{Bolus_1CPTMM}},
-\code{\link{Bolus_2CPTMM}},
 \code{\link{Bolus_2CPT}},
-\code{\link{Infusion_1CPTMM}},
+\code{\link{Bolus_2CPTMM}},
 \code{\link{Infusion_1CPT}},
-\code{\link{Infusion_2CPTMM}},
+\code{\link{Infusion_1CPTMM}},
 \code{\link{Infusion_2CPT}},
-\code{\link{Oral_1CPTMM}},
+\code{\link{Infusion_2CPTMM}},
 \code{\link{Oral_1CPT}},
-\code{\link{Oral_2CPTMM}},
+\code{\link{Oral_1CPTMM}},
 \code{\link{Oral_2CPT}},
+\code{\link{Oral_2CPTMM}},
 \code{\link{Wang2007}},
 \code{\link{mavoglurant}},
+\code{\link{neonatal_wt}},
 \code{\link{nimoData}},
 \code{\link{nmtest}},
 \code{\link{pheno_sd}},
diff --git a/man/Bolus_1CPTMM.Rd b/man/Bolus_1CPTMM.Rd
index f6e66f8..80543f8 100644
--- a/man/Bolus_1CPTMM.Rd
+++ b/man/Bolus_1CPTMM.Rd
@@ -56,20 +56,21 @@ samples in 24 hours per subject, using a first-order absorption,
 1-compartment disposition, linear elimination model.
 }
 \seealso{
-Other nlmixr2 datasets: 
+Other nlmixr2 datasets:
 \code{\link{Bolus_1CPT}},
-\code{\link{Bolus_2CPTMM}},
 \code{\link{Bolus_2CPT}},
-\code{\link{Infusion_1CPTMM}},
+\code{\link{Bolus_2CPTMM}},
 \code{\link{Infusion_1CPT}},
-\code{\link{Infusion_2CPTMM}},
+\code{\link{Infusion_1CPTMM}},
 \code{\link{Infusion_2CPT}},
-\code{\link{Oral_1CPTMM}},
+\code{\link{Infusion_2CPTMM}},
 \code{\link{Oral_1CPT}},
-\code{\link{Oral_2CPTMM}},
+\code{\link{Oral_1CPTMM}},
 \code{\link{Oral_2CPT}},
+\code{\link{Oral_2CPTMM}},
 \code{\link{Wang2007}},
 \code{\link{mavoglurant}},
+\code{\link{neonatal_wt}},
 \code{\link{nimoData}},
 \code{\link{nmtest}},
 \code{\link{pheno_sd}},
diff --git a/man/Bolus_2CPT.Rd b/man/Bolus_2CPT.Rd
index 86229af..9cc21d7 100644
--- a/man/Bolus_2CPT.Rd
+++ b/man/Bolus_2CPT.Rd
@@ -59,20 +59,21 @@ samples in 24 hours per subject, using a first-order absorption,
 1-compartment disposition, linear elimination model.
 }
 \seealso{
-Other nlmixr2 datasets: 
-\code{\link{Bolus_1CPTMM}},
+Other nlmixr2 datasets:
 \code{\link{Bolus_1CPT}},
+\code{\link{Bolus_1CPTMM}},
 \code{\link{Bolus_2CPTMM}},
-\code{\link{Infusion_1CPTMM}},
 \code{\link{Infusion_1CPT}},
-\code{\link{Infusion_2CPTMM}},
+\code{\link{Infusion_1CPTMM}},
 \code{\link{Infusion_2CPT}},
-\code{\link{Oral_1CPTMM}},
+\code{\link{Infusion_2CPTMM}},
 \code{\link{Oral_1CPT}},
-\code{\link{Oral_2CPTMM}},
+\code{\link{Oral_1CPTMM}},
 \code{\link{Oral_2CPT}},
+\code{\link{Oral_2CPTMM}},
 \code{\link{Wang2007}},
 \code{\link{mavoglurant}},
+\code{\link{neonatal_wt}},
 \code{\link{nimoData}},
 \code{\link{nmtest}},
 \code{\link{pheno_sd}},
diff --git a/man/Bolus_2CPTMM.Rd b/man/Bolus_2CPTMM.Rd
index 8e3be08..9f99650 100644
--- a/man/Bolus_2CPTMM.Rd
+++ b/man/Bolus_2CPTMM.Rd
@@ -58,20 +58,21 @@ samples in 24 hours per subject, using a first-order absorption,
 1-compartment disposition, linear elimination model.
 }
 \seealso{
-Other nlmixr2 datasets: 
-\code{\link{Bolus_1CPTMM}},
+Other nlmixr2 datasets:
 \code{\link{Bolus_1CPT}},
+\code{\link{Bolus_1CPTMM}},
 \code{\link{Bolus_2CPT}},
-\code{\link{Infusion_1CPTMM}},
 \code{\link{Infusion_1CPT}},
-\code{\link{Infusion_2CPTMM}},
+\code{\link{Infusion_1CPTMM}},
 \code{\link{Infusion_2CPT}},
-\code{\link{Oral_1CPTMM}},
+\code{\link{Infusion_2CPTMM}},
 \code{\link{Oral_1CPT}},
-\code{\link{Oral_2CPTMM}},
+\code{\link{Oral_1CPTMM}},
 \code{\link{Oral_2CPT}},
+\code{\link{Oral_2CPTMM}},
 \code{\link{Wang2007}},
 \code{\link{mavoglurant}},
+\code{\link{neonatal_wt}},
 \code{\link{nimoData}},
 \code{\link{nmtest}},
 \code{\link{pheno_sd}},
diff --git a/man/Infusion_1CPT.Rd b/man/Infusion_1CPT.Rd
index f914ec3..a8bc125 100644
--- a/man/Infusion_1CPT.Rd
+++ b/man/Infusion_1CPT.Rd
@@ -58,20 +58,21 @@ samples in 24 hours per subject, using a first-order absorption,
 1-compartment disposition, linear elimination model.
 }
 \seealso{
-Other nlmixr2 datasets: 
-\code{\link{Bolus_1CPTMM}},
+Other nlmixr2 datasets:
 \code{\link{Bolus_1CPT}},
-\code{\link{Bolus_2CPTMM}},
+\code{\link{Bolus_1CPTMM}},
 \code{\link{Bolus_2CPT}},
+\code{\link{Bolus_2CPTMM}},
 \code{\link{Infusion_1CPTMM}},
-\code{\link{Infusion_2CPTMM}},
 \code{\link{Infusion_2CPT}},
-\code{\link{Oral_1CPTMM}},
+\code{\link{Infusion_2CPTMM}},
 \code{\link{Oral_1CPT}},
-\code{\link{Oral_2CPTMM}},
+\code{\link{Oral_1CPTMM}},
 \code{\link{Oral_2CPT}},
+\code{\link{Oral_2CPTMM}},
 \code{\link{Wang2007}},
 \code{\link{mavoglurant}},
+\code{\link{neonatal_wt}},
 \code{\link{nimoData}},
 \code{\link{nmtest}},
 \code{\link{pheno_sd}},
diff --git a/man/Infusion_1CPTMM.Rd b/man/Infusion_1CPTMM.Rd
index f64bd61..e06809f 100644
--- a/man/Infusion_1CPTMM.Rd
+++ b/man/Infusion_1CPTMM.Rd
@@ -57,20 +57,21 @@ samples in 24 hours per subject, using a first-order absorption,
 1-compartment disposition, linear elimination model.
 }
 \seealso{
-Other nlmixr2 datasets: 
-\code{\link{Bolus_1CPTMM}},
+Other nlmixr2 datasets:
 \code{\link{Bolus_1CPT}},
-\code{\link{Bolus_2CPTMM}},
+\code{\link{Bolus_1CPTMM}},
 \code{\link{Bolus_2CPT}},
+\code{\link{Bolus_2CPTMM}},
 \code{\link{Infusion_1CPT}},
-\code{\link{Infusion_2CPTMM}},
 \code{\link{Infusion_2CPT}},
-\code{\link{Oral_1CPTMM}},
+\code{\link{Infusion_2CPTMM}},
 \code{\link{Oral_1CPT}},
-\code{\link{Oral_2CPTMM}},
+\code{\link{Oral_1CPTMM}},
 \code{\link{Oral_2CPT}},
+\code{\link{Oral_2CPTMM}},
 \code{\link{Wang2007}},
 \code{\link{mavoglurant}},
+\code{\link{neonatal_wt}},
 \code{\link{nimoData}},
 \code{\link{nmtest}},
 \code{\link{pheno_sd}},
diff --git a/man/Infusion_2CPT.Rd b/man/Infusion_2CPT.Rd
index 1af4f34..b0d4f26 100644
--- a/man/Infusion_2CPT.Rd
+++ b/man/Infusion_2CPT.Rd
@@ -60,20 +60,21 @@ samples in 24 hours per subject, using a first-order absorption,
 1-compartment disposition, linear elimination model.
 }
 \seealso{
-Other nlmixr2 datasets: 
-\code{\link{Bolus_1CPTMM}},
+Other nlmixr2 datasets:
 \code{\link{Bolus_1CPT}},
-\code{\link{Bolus_2CPTMM}},
+\code{\link{Bolus_1CPTMM}},
 \code{\link{Bolus_2CPT}},
-\code{\link{Infusion_1CPTMM}},
+\code{\link{Bolus_2CPTMM}},
 \code{\link{Infusion_1CPT}},
+\code{\link{Infusion_1CPTMM}},
 \code{\link{Infusion_2CPTMM}},
-\code{\link{Oral_1CPTMM}},
 \code{\link{Oral_1CPT}},
-\code{\link{Oral_2CPTMM}},
+\code{\link{Oral_1CPTMM}},
 \code{\link{Oral_2CPT}},
+\code{\link{Oral_2CPTMM}},
 \code{\link{Wang2007}},
 \code{\link{mavoglurant}},
+\code{\link{neonatal_wt}},
 \code{\link{nimoData}},
 \code{\link{nmtest}},
 \code{\link{pheno_sd}},
diff --git a/man/Infusion_2CPTMM.Rd b/man/Infusion_2CPTMM.Rd
index 8c88102..8e04651 100644
--- a/man/Infusion_2CPTMM.Rd
+++ b/man/Infusion_2CPTMM.Rd
@@ -59,20 +59,21 @@ samples in 24 hours per subject, using a first-order absorption,
 1-compartment disposition, linear elimination model.
 }
 \seealso{
-Other nlmixr2 datasets: 
-\code{\link{Bolus_1CPTMM}},
+Other nlmixr2 datasets:
 \code{\link{Bolus_1CPT}},
-\code{\link{Bolus_2CPTMM}},
+\code{\link{Bolus_1CPTMM}},
 \code{\link{Bolus_2CPT}},
-\code{\link{Infusion_1CPTMM}},
+\code{\link{Bolus_2CPTMM}},
 \code{\link{Infusion_1CPT}},
+\code{\link{Infusion_1CPTMM}},
 \code{\link{Infusion_2CPT}},
-\code{\link{Oral_1CPTMM}},
 \code{\link{Oral_1CPT}},
-\code{\link{Oral_2CPTMM}},
+\code{\link{Oral_1CPTMM}},
 \code{\link{Oral_2CPT}},
+\code{\link{Oral_2CPTMM}},
 \code{\link{Wang2007}},
 \code{\link{mavoglurant}},
+\code{\link{neonatal_wt}},
 \code{\link{nimoData}},
 \code{\link{nmtest}},
 \code{\link{pheno_sd}},
diff --git a/man/Oral_1CPT.Rd b/man/Oral_1CPT.Rd
index 4591169..39123e3 100644
--- a/man/Oral_1CPT.Rd
+++ b/man/Oral_1CPT.Rd
@@ -58,20 +58,21 @@ samples in 24 hours per subject, using a first-order absorption,
 1-compartment disposition, linear elimination model.
 }
 \seealso{
-Other nlmixr2 datasets: 
-\code{\link{Bolus_1CPTMM}},
+Other nlmixr2 datasets:
 \code{\link{Bolus_1CPT}},
-\code{\link{Bolus_2CPTMM}},
+\code{\link{Bolus_1CPTMM}},
 \code{\link{Bolus_2CPT}},
-\code{\link{Infusion_1CPTMM}},
+\code{\link{Bolus_2CPTMM}},
 \code{\link{Infusion_1CPT}},
-\code{\link{Infusion_2CPTMM}},
+\code{\link{Infusion_1CPTMM}},
 \code{\link{Infusion_2CPT}},
+\code{\link{Infusion_2CPTMM}},
 \code{\link{Oral_1CPTMM}},
-\code{\link{Oral_2CPTMM}},
 \code{\link{Oral_2CPT}},
+\code{\link{Oral_2CPTMM}},
 \code{\link{Wang2007}},
 \code{\link{mavoglurant}},
+\code{\link{neonatal_wt}},
 \code{\link{nimoData}},
 \code{\link{nmtest}},
 \code{\link{pheno_sd}},
diff --git a/man/Oral_1CPTMM.Rd b/man/Oral_1CPTMM.Rd
index fa54ca6..57484cc 100644
--- a/man/Oral_1CPTMM.Rd
+++ b/man/Oral_1CPTMM.Rd
@@ -57,20 +57,21 @@ samples in 24 hours per subject, using a first-order absorption,
 1-compartment disposition, linear elimination model.
 }
 \seealso{
-Other nlmixr2 datasets: 
-\code{\link{Bolus_1CPTMM}},
+Other nlmixr2 datasets:
 \code{\link{Bolus_1CPT}},
-\code{\link{Bolus_2CPTMM}},
+\code{\link{Bolus_1CPTMM}},
 \code{\link{Bolus_2CPT}},
-\code{\link{Infusion_1CPTMM}},
+\code{\link{Bolus_2CPTMM}},
 \code{\link{Infusion_1CPT}},
-\code{\link{Infusion_2CPTMM}},
+\code{\link{Infusion_1CPTMM}},
 \code{\link{Infusion_2CPT}},
+\code{\link{Infusion_2CPTMM}},
 \code{\link{Oral_1CPT}},
-\code{\link{Oral_2CPTMM}},
 \code{\link{Oral_2CPT}},
+\code{\link{Oral_2CPTMM}},
 \code{\link{Wang2007}},
 \code{\link{mavoglurant}},
+\code{\link{neonatal_wt}},
 \code{\link{nimoData}},
 \code{\link{nmtest}},
 \code{\link{pheno_sd}},
diff --git a/man/Oral_2CPT.Rd b/man/Oral_2CPT.Rd
index 3cc8f38..7c90b8b 100644
--- a/man/Oral_2CPT.Rd
+++ b/man/Oral_2CPT.Rd
@@ -60,20 +60,21 @@ samples in 24 hours per subject, using a first-order absorption,
 1-compartment disposition, linear elimination model.
 }
 \seealso{
-Other nlmixr2 datasets: 
-\code{\link{Bolus_1CPTMM}},
+Other nlmixr2 datasets:
 \code{\link{Bolus_1CPT}},
-\code{\link{Bolus_2CPTMM}},
+\code{\link{Bolus_1CPTMM}},
 \code{\link{Bolus_2CPT}},
-\code{\link{Infusion_1CPTMM}},
+\code{\link{Bolus_2CPTMM}},
 \code{\link{Infusion_1CPT}},
-\code{\link{Infusion_2CPTMM}},
+\code{\link{Infusion_1CPTMM}},
 \code{\link{Infusion_2CPT}},
-\code{\link{Oral_1CPTMM}},
+\code{\link{Infusion_2CPTMM}},
 \code{\link{Oral_1CPT}},
+\code{\link{Oral_1CPTMM}},
 \code{\link{Oral_2CPTMM}},
 \code{\link{Wang2007}},
 \code{\link{mavoglurant}},
+\code{\link{neonatal_wt}},
 \code{\link{nimoData}},
 \code{\link{nmtest}},
 \code{\link{pheno_sd}},
diff --git a/man/Oral_2CPTMM.Rd b/man/Oral_2CPTMM.Rd
index b94e79e..e17a3b9 100644
--- a/man/Oral_2CPTMM.Rd
+++ b/man/Oral_2CPTMM.Rd
@@ -59,20 +59,21 @@ samples in 24 hours per subject, using a first-order absorption,
 1-compartment disposition, linear elimination model.
 }
 \seealso{
-Other nlmixr2 datasets: 
-\code{\link{Bolus_1CPTMM}},
+Other nlmixr2 datasets:
 \code{\link{Bolus_1CPT}},
-\code{\link{Bolus_2CPTMM}},
+\code{\link{Bolus_1CPTMM}},
 \code{\link{Bolus_2CPT}},
-\code{\link{Infusion_1CPTMM}},
+\code{\link{Bolus_2CPTMM}},
 \code{\link{Infusion_1CPT}},
-\code{\link{Infusion_2CPTMM}},
+\code{\link{Infusion_1CPTMM}},
 \code{\link{Infusion_2CPT}},
-\code{\link{Oral_1CPTMM}},
+\code{\link{Infusion_2CPTMM}},
 \code{\link{Oral_1CPT}},
+\code{\link{Oral_1CPTMM}},
 \code{\link{Oral_2CPT}},
 \code{\link{Wang2007}},
 \code{\link{mavoglurant}},
+\code{\link{neonatal_wt}},
 \code{\link{nimoData}},
 \code{\link{nmtest}},
 \code{\link{pheno_sd}},
diff --git a/man/Wang2007.Rd b/man/Wang2007.Rd
index 350ffda..ff2cdf9 100644
--- a/man/Wang2007.Rd
+++ b/man/Wang2007.Rd
@@ -25,20 +25,21 @@ estimation methods (Laplace FO, FOCE with and without
 interaction) are described.
 }
 \seealso{
-Other nlmixr2 datasets: 
-\code{\link{Bolus_1CPTMM}},
+Other nlmixr2 datasets:
 \code{\link{Bolus_1CPT}},
-\code{\link{Bolus_2CPTMM}},
+\code{\link{Bolus_1CPTMM}},
 \code{\link{Bolus_2CPT}},
-\code{\link{Infusion_1CPTMM}},
+\code{\link{Bolus_2CPTMM}},
 \code{\link{Infusion_1CPT}},
-\code{\link{Infusion_2CPTMM}},
+\code{\link{Infusion_1CPTMM}},
 \code{\link{Infusion_2CPT}},
-\code{\link{Oral_1CPTMM}},
+\code{\link{Infusion_2CPTMM}},
 \code{\link{Oral_1CPT}},
-\code{\link{Oral_2CPTMM}},
+\code{\link{Oral_1CPTMM}},
 \code{\link{Oral_2CPT}},
+\code{\link{Oral_2CPTMM}},
 \code{\link{mavoglurant}},
+\code{\link{neonatal_wt}},
 \code{\link{nimoData}},
 \code{\link{nmtest}},
 \code{\link{pheno_sd}},
diff --git a/man/mavoglurant.Rd b/man/mavoglurant.Rd
index cca00f2..b25ec6e 100644
--- a/man/mavoglurant.Rd
+++ b/man/mavoglurant.Rd
@@ -34,20 +34,21 @@ This was used in a full PBPK model. This one was published for mavoglurant
 (Wendling et al. 2016).
 }
 \seealso{
-Other nlmixr2 datasets: 
-\code{\link{Bolus_1CPTMM}},
+Other nlmixr2 datasets:
 \code{\link{Bolus_1CPT}},
-\code{\link{Bolus_2CPTMM}},
+\code{\link{Bolus_1CPTMM}},
 \code{\link{Bolus_2CPT}},
-\code{\link{Infusion_1CPTMM}},
+\code{\link{Bolus_2CPTMM}},
 \code{\link{Infusion_1CPT}},
-\code{\link{Infusion_2CPTMM}},
+\code{\link{Infusion_1CPTMM}},
 \code{\link{Infusion_2CPT}},
-\code{\link{Oral_1CPTMM}},
+\code{\link{Infusion_2CPTMM}},
 \code{\link{Oral_1CPT}},
-\code{\link{Oral_2CPTMM}},
+\code{\link{Oral_1CPTMM}},
 \code{\link{Oral_2CPT}},
+\code{\link{Oral_2CPTMM}},
 \code{\link{Wang2007}},
+\code{\link{neonatal_wt}},
 \code{\link{nimoData}},
 \code{\link{nmtest}},
 \code{\link{pheno_sd}},
diff --git a/man/neonatal_wt.Rd b/man/neonatal_wt.Rd
new file mode 100644
index 0000000..7283ba2
--- /dev/null
+++ b/man/neonatal_wt.Rd
@@ -0,0 +1,62 @@
+% Generated by roxygen2: do not edit by hand
+% Please edit documentation in R/data_neonatal_wt.R
+\docType{data}
+\name{neonatal_wt}
+\alias{neonatal_wt}
+\title{Neonatal weight progression data}
+\format{
+A data frame with 1120 rows by 9 columns
+
+\describe{
+\item{ID}{Subject ID (189 neonates)}
+\item{TIME}{Time since birth (days)}
+\item{DV}{Dependent Variable, body weight (g)}
+\item{EVID}{rxode2/nlmixr2 event ID (0 = observation; no dosing)}
+\item{Sex}{Sex, 0/1}
+\item{DelM}{Delivery mode, 0/1}
+\item{GA}{Gestational age at birth (weeks)}
+\item{Mage}{Maternal age (years)}
+\item{Para2}{Parity indicator, 0/1}
+}
+}
+\source{
+Rohleff et al. (2025), CPT: Pharmacometrics & Systems Pharmacology
+}
+\usage{
+neonatal_wt
+}
+\description{
+Longitudinal body-weight measurements for a cohort of neonates over roughly
+the first week of life, used as the second case study (neonatal weight
+progression) in Rohleff et al. (2025) on VAE-based nonlinear mixed-effects
+modeling. There is no dosing; body weight follows a turnover (zero-order
+production, first-order elimination) growth model whose initial weight is an
+estimated parameter, so every record is an observation (\code{EVID = 0}).
+}
+\seealso{
+Other nlmixr2 datasets:
+\code{\link{Bolus_1CPT}},
+\code{\link{Bolus_1CPTMM}},
+\code{\link{Bolus_2CPT}},
+\code{\link{Bolus_2CPTMM}},
+\code{\link{Infusion_1CPT}},
+\code{\link{Infusion_1CPTMM}},
+\code{\link{Infusion_2CPT}},
+\code{\link{Infusion_2CPTMM}},
+\code{\link{Oral_1CPT}},
+\code{\link{Oral_1CPTMM}},
+\code{\link{Oral_2CPT}},
+\code{\link{Oral_2CPTMM}},
+\code{\link{Wang2007}},
+\code{\link{mavoglurant}},
+\code{\link{nimoData}},
+\code{\link{nmtest}},
+\code{\link{pheno_sd}},
+\code{\link{rats}},
+\code{\link{theo_md}},
+\code{\link{theo_sd}},
+\code{\link{warfarin}},
+\code{\link{wbcSim}}
+}
+\concept{nlmixr2 datasets}
+\keyword{datasets}
diff --git a/man/nimoData.Rd b/man/nimoData.Rd
index 0375dd3..e643f11 100644
--- a/man/nimoData.Rd
+++ b/man/nimoData.Rd
@@ -33,21 +33,22 @@ nimoData
 }
 }
 \seealso{
-Other nlmixr2 datasets: 
-\code{\link{Bolus_1CPTMM}},
+Other nlmixr2 datasets:
 \code{\link{Bolus_1CPT}},
-\code{\link{Bolus_2CPTMM}},
+\code{\link{Bolus_1CPTMM}},
 \code{\link{Bolus_2CPT}},
-\code{\link{Infusion_1CPTMM}},
+\code{\link{Bolus_2CPTMM}},
 \code{\link{Infusion_1CPT}},
-\code{\link{Infusion_2CPTMM}},
+\code{\link{Infusion_1CPTMM}},
 \code{\link{Infusion_2CPT}},
-\code{\link{Oral_1CPTMM}},
+\code{\link{Infusion_2CPTMM}},
 \code{\link{Oral_1CPT}},
-\code{\link{Oral_2CPTMM}},
+\code{\link{Oral_1CPTMM}},
 \code{\link{Oral_2CPT}},
+\code{\link{Oral_2CPTMM}},
 \code{\link{Wang2007}},
 \code{\link{mavoglurant}},
+\code{\link{neonatal_wt}},
 \code{\link{nmtest}},
 \code{\link{pheno_sd}},
 \code{\link{rats}},
diff --git a/man/nmtest.Rd b/man/nmtest.Rd
index d1e9424..74be5a8 100644
--- a/man/nmtest.Rd
+++ b/man/nmtest.Rd
@@ -44,21 +44,22 @@ are options to make \code{rxode2}/\code{nlmixr2} behave more like NONMEM.
 However behaviors we believe are wrong we do not support.
 }
 \seealso{
-Other nlmixr2 datasets: 
-\code{\link{Bolus_1CPTMM}},
+Other nlmixr2 datasets:
 \code{\link{Bolus_1CPT}},
-\code{\link{Bolus_2CPTMM}},
+\code{\link{Bolus_1CPTMM}},
 \code{\link{Bolus_2CPT}},
-\code{\link{Infusion_1CPTMM}},
+\code{\link{Bolus_2CPTMM}},
 \code{\link{Infusion_1CPT}},
-\code{\link{Infusion_2CPTMM}},
+\code{\link{Infusion_1CPTMM}},
 \code{\link{Infusion_2CPT}},
-\code{\link{Oral_1CPTMM}},
+\code{\link{Infusion_2CPTMM}},
 \code{\link{Oral_1CPT}},
-\code{\link{Oral_2CPTMM}},
+\code{\link{Oral_1CPTMM}},
 \code{\link{Oral_2CPT}},
+\code{\link{Oral_2CPTMM}},
 \code{\link{Wang2007}},
 \code{\link{mavoglurant}},
+\code{\link{neonatal_wt}},
 \code{\link{nimoData}},
 \code{\link{pheno_sd}},
 \code{\link{rats}},
diff --git a/man/pheno_sd.Rd b/man/pheno_sd.Rd
index d604e2a..f27501c 100644
--- a/man/pheno_sd.Rd
+++ b/man/pheno_sd.Rd
@@ -48,21 +48,22 @@ analyzed in Boeckmann, Sheiner and Beal (1994), in Davidian and
 Giltinan (1995), and in Littell et al. (1996).
 }
 \seealso{
-Other nlmixr2 datasets: 
-\code{\link{Bolus_1CPTMM}},
+Other nlmixr2 datasets:
 \code{\link{Bolus_1CPT}},
-\code{\link{Bolus_2CPTMM}},
+\code{\link{Bolus_1CPTMM}},
 \code{\link{Bolus_2CPT}},
-\code{\link{Infusion_1CPTMM}},
+\code{\link{Bolus_2CPTMM}},
 \code{\link{Infusion_1CPT}},
-\code{\link{Infusion_2CPTMM}},
+\code{\link{Infusion_1CPTMM}},
 \code{\link{Infusion_2CPT}},
-\code{\link{Oral_1CPTMM}},
+\code{\link{Infusion_2CPTMM}},
 \code{\link{Oral_1CPT}},
-\code{\link{Oral_2CPTMM}},
+\code{\link{Oral_1CPTMM}},
 \code{\link{Oral_2CPT}},
+\code{\link{Oral_2CPTMM}},
 \code{\link{Wang2007}},
 \code{\link{mavoglurant}},
+\code{\link{neonatal_wt}},
 \code{\link{nimoData}},
 \code{\link{nmtest}},
 \code{\link{rats}},
diff --git a/man/rats.Rd b/man/rats.Rd
index baecd70..5510786 100644
--- a/man/rats.Rd
+++ b/man/rats.Rd
@@ -48,21 +48,22 @@ Ochi, Y. and Prentice, R. L. (1984),
 Biometrika, 71, 531-543.
 }
 \seealso{
-Other nlmixr2 datasets: 
-\code{\link{Bolus_1CPTMM}},
+Other nlmixr2 datasets:
 \code{\link{Bolus_1CPT}},
-\code{\link{Bolus_2CPTMM}},
+\code{\link{Bolus_1CPTMM}},
 \code{\link{Bolus_2CPT}},
-\code{\link{Infusion_1CPTMM}},
+\code{\link{Bolus_2CPTMM}},
 \code{\link{Infusion_1CPT}},
-\code{\link{Infusion_2CPTMM}},
+\code{\link{Infusion_1CPTMM}},
 \code{\link{Infusion_2CPT}},
-\code{\link{Oral_1CPTMM}},
+\code{\link{Infusion_2CPTMM}},
 \code{\link{Oral_1CPT}},
-\code{\link{Oral_2CPTMM}},
+\code{\link{Oral_1CPTMM}},
 \code{\link{Oral_2CPT}},
+\code{\link{Oral_2CPTMM}},
 \code{\link{Wang2007}},
 \code{\link{mavoglurant}},
+\code{\link{neonatal_wt}},
 \code{\link{nimoData}},
 \code{\link{nmtest}},
 \code{\link{pheno_sd}},
diff --git a/man/theo_md.Rd b/man/theo_md.Rd
index cea50fe..3e3940c 100644
--- a/man/theo_md.Rd
+++ b/man/theo_md.Rd
@@ -30,21 +30,22 @@ concentrations were simulated with once a day regimen for 7 days
 (QD).
 }
 \seealso{
-Other nlmixr2 datasets: 
-\code{\link{Bolus_1CPTMM}},
+Other nlmixr2 datasets:
 \code{\link{Bolus_1CPT}},
-\code{\link{Bolus_2CPTMM}},
+\code{\link{Bolus_1CPTMM}},
 \code{\link{Bolus_2CPT}},
-\code{\link{Infusion_1CPTMM}},
+\code{\link{Bolus_2CPTMM}},
 \code{\link{Infusion_1CPT}},
-\code{\link{Infusion_2CPTMM}},
+\code{\link{Infusion_1CPTMM}},
 \code{\link{Infusion_2CPT}},
-\code{\link{Oral_1CPTMM}},
+\code{\link{Infusion_2CPTMM}},
 \code{\link{Oral_1CPT}},
-\code{\link{Oral_2CPTMM}},
+\code{\link{Oral_1CPTMM}},
 \code{\link{Oral_2CPT}},
+\code{\link{Oral_2CPTMM}},
 \code{\link{Wang2007}},
 \code{\link{mavoglurant}},
+\code{\link{neonatal_wt}},
 \code{\link{nimoData}},
 \code{\link{nmtest}},
 \code{\link{pheno_sd}},
diff --git a/man/theo_sd.Rd b/man/theo_sd.Rd
index 1fdb089..7470171 100644
--- a/man/theo_sd.Rd
+++ b/man/theo_sd.Rd
@@ -28,21 +28,22 @@ This data set is  the day 1 concentrations of the
 theophylline data that is included in the nlme/NONMEM.
 }
 \seealso{
-Other nlmixr2 datasets: 
-\code{\link{Bolus_1CPTMM}},
+Other nlmixr2 datasets:
 \code{\link{Bolus_1CPT}},
-\code{\link{Bolus_2CPTMM}},
+\code{\link{Bolus_1CPTMM}},
 \code{\link{Bolus_2CPT}},
-\code{\link{Infusion_1CPTMM}},
+\code{\link{Bolus_2CPTMM}},
 \code{\link{Infusion_1CPT}},
-\code{\link{Infusion_2CPTMM}},
+\code{\link{Infusion_1CPTMM}},
 \code{\link{Infusion_2CPT}},
-\code{\link{Oral_1CPTMM}},
+\code{\link{Infusion_2CPTMM}},
 \code{\link{Oral_1CPT}},
-\code{\link{Oral_2CPTMM}},
+\code{\link{Oral_1CPTMM}},
 \code{\link{Oral_2CPT}},
+\code{\link{Oral_2CPTMM}},
 \code{\link{Wang2007}},
 \code{\link{mavoglurant}},
+\code{\link{neonatal_wt}},
 \code{\link{nimoData}},
 \code{\link{nmtest}},
 \code{\link{pheno_sd}},
diff --git a/man/warfarin.Rd b/man/warfarin.Rd
index 1de6340..5b28d5a 100644
--- a/man/warfarin.Rd
+++ b/man/warfarin.Rd
@@ -39,21 +39,22 @@ Initiation of warfarin therapy without a loading dose. Circulation
 1968; 38: 169-177.
 }
 \seealso{
-Other nlmixr2 datasets: 
-\code{\link{Bolus_1CPTMM}},
+Other nlmixr2 datasets:
 \code{\link{Bolus_1CPT}},
-\code{\link{Bolus_2CPTMM}},
+\code{\link{Bolus_1CPTMM}},
 \code{\link{Bolus_2CPT}},
-\code{\link{Infusion_1CPTMM}},
+\code{\link{Bolus_2CPTMM}},
 \code{\link{Infusion_1CPT}},
-\code{\link{Infusion_2CPTMM}},
+\code{\link{Infusion_1CPTMM}},
 \code{\link{Infusion_2CPT}},
-\code{\link{Oral_1CPTMM}},
+\code{\link{Infusion_2CPTMM}},
 \code{\link{Oral_1CPT}},
-\code{\link{Oral_2CPTMM}},
+\code{\link{Oral_1CPTMM}},
 \code{\link{Oral_2CPT}},
+\code{\link{Oral_2CPTMM}},
 \code{\link{Wang2007}},
 \code{\link{mavoglurant}},
+\code{\link{neonatal_wt}},
 \code{\link{nimoData}},
 \code{\link{nmtest}},
 \code{\link{pheno_sd}},
diff --git a/man/wbcSim.Rd b/man/wbcSim.Rd
index 83023c7..dc849cc 100644
--- a/man/wbcSim.Rd
+++ b/man/wbcSim.Rd
@@ -28,21 +28,22 @@ wbcSim
 }
 }
 \seealso{
-Other nlmixr2 datasets: 
-\code{\link{Bolus_1CPTMM}},
+Other nlmixr2 datasets:
 \code{\link{Bolus_1CPT}},
-\code{\link{Bolus_2CPTMM}},
+\code{\link{Bolus_1CPTMM}},
 \code{\link{Bolus_2CPT}},
-\code{\link{Infusion_1CPTMM}},
+\code{\link{Bolus_2CPTMM}},
 \code{\link{Infusion_1CPT}},
-\code{\link{Infusion_2CPTMM}},
+\code{\link{Infusion_1CPTMM}},
 \code{\link{Infusion_2CPT}},
-\code{\link{Oral_1CPTMM}},
+\code{\link{Infusion_2CPTMM}},
 \code{\link{Oral_1CPT}},
-\code{\link{Oral_2CPTMM}},
+\code{\link{Oral_1CPTMM}},
 \code{\link{Oral_2CPT}},
+\code{\link{Oral_2CPTMM}},
 \code{\link{Wang2007}},
 \code{\link{mavoglurant}},
+\code{\link{neonatal_wt}},
 \code{\link{nimoData}},
 \code{\link{nmtest}},
 \code{\link{pheno_sd}},