diff --git a/DESCRIPTION b/DESCRIPTION index af7fbd4..480ba92 100644 --- a/DESCRIPTION +++ b/DESCRIPTION @@ -30,10 +30,10 @@ Description: Datasets for 'nlmixr2' and 'rxode2'. 'nlmixr2' is used for fitting License: GPL (>= 3) Encoding: UTF-8 Roxygen: list(markdown = TRUE) -RoxygenNote: 7.2.3 Depends: R (>= 2.10) LazyData: true BugReports: https://github.com/nlmixr2/nlmixr2data/issues/ URL: https://nlmixr2.github.io/nlmixr2data/, https://github.com/nlmixr2/nlmixr2data/ +Config/roxygen2/version: 8.0.0 diff --git a/R/data_neonatal_wt.R b/R/data_neonatal_wt.R new file mode 100644 index 0000000..aff1373 --- /dev/null +++ b/R/data_neonatal_wt.R @@ -0,0 +1,26 @@ +#' Neonatal weight progression data +#' +#' Longitudinal body-weight measurements for a cohort of neonates over roughly +#' the first week of life, used as the second case study (neonatal weight +#' progression) in Rohleff et al. (2025) on VAE-based nonlinear mixed-effects +#' modeling. There is no dosing; body weight follows a turnover (zero-order +#' production, first-order elimination) growth model whose initial weight is an +#' estimated parameter, so every record is an observation (\code{EVID = 0}). +#' +#' @format A data frame with 1120 rows by 9 columns +#' +#' \describe{ +#' \item{ID}{Subject ID (189 neonates)} +#' \item{TIME}{Time since birth (days)} +#' \item{DV}{Dependent Variable, body weight (g)} +#' \item{EVID}{rxode2/nlmixr2 event ID (0 = observation; no dosing)} +#' \item{Sex}{Sex, 0/1} +#' \item{DelM}{Delivery mode, 0/1} +#' \item{GA}{Gestational age at birth (weeks)} +#' \item{Mage}{Maternal age (years)} +#' \item{Para2}{Parity indicator, 0/1} +#' } +#' +#' @source Rohleff et al. (2025), CPT: Pharmacometrics & Systems Pharmacology +#' @family nlmixr2 datasets +"neonatal_wt" diff --git a/data/neonatal_wt.rda b/data/neonatal_wt.rda new file mode 100644 index 0000000..5bcd9c8 Binary files /dev/null and b/data/neonatal_wt.rda differ diff --git a/man/Bolus_1CPT.Rd b/man/Bolus_1CPT.Rd index f034100..edd4d1a 100644 --- a/man/Bolus_1CPT.Rd +++ b/man/Bolus_1CPT.Rd @@ -57,20 +57,21 @@ samples in 24 hours per subject, using a first-order absorption, 1-compartment disposition, linear elimination model. } \seealso{ -Other nlmixr2 datasets: +Other nlmixr2 datasets: \code{\link{Bolus_1CPTMM}}, -\code{\link{Bolus_2CPTMM}}, \code{\link{Bolus_2CPT}}, -\code{\link{Infusion_1CPTMM}}, +\code{\link{Bolus_2CPTMM}}, \code{\link{Infusion_1CPT}}, -\code{\link{Infusion_2CPTMM}}, +\code{\link{Infusion_1CPTMM}}, \code{\link{Infusion_2CPT}}, -\code{\link{Oral_1CPTMM}}, +\code{\link{Infusion_2CPTMM}}, \code{\link{Oral_1CPT}}, -\code{\link{Oral_2CPTMM}}, +\code{\link{Oral_1CPTMM}}, \code{\link{Oral_2CPT}}, +\code{\link{Oral_2CPTMM}}, \code{\link{Wang2007}}, \code{\link{mavoglurant}}, +\code{\link{neonatal_wt}}, \code{\link{nimoData}}, \code{\link{nmtest}}, \code{\link{pheno_sd}}, diff --git a/man/Bolus_1CPTMM.Rd b/man/Bolus_1CPTMM.Rd index f6e66f8..80543f8 100644 --- a/man/Bolus_1CPTMM.Rd +++ b/man/Bolus_1CPTMM.Rd @@ -56,20 +56,21 @@ samples in 24 hours per subject, using a first-order absorption, 1-compartment disposition, linear elimination model. } \seealso{ -Other nlmixr2 datasets: +Other nlmixr2 datasets: \code{\link{Bolus_1CPT}}, -\code{\link{Bolus_2CPTMM}}, \code{\link{Bolus_2CPT}}, -\code{\link{Infusion_1CPTMM}}, +\code{\link{Bolus_2CPTMM}}, \code{\link{Infusion_1CPT}}, -\code{\link{Infusion_2CPTMM}}, +\code{\link{Infusion_1CPTMM}}, \code{\link{Infusion_2CPT}}, -\code{\link{Oral_1CPTMM}}, +\code{\link{Infusion_2CPTMM}}, \code{\link{Oral_1CPT}}, -\code{\link{Oral_2CPTMM}}, +\code{\link{Oral_1CPTMM}}, \code{\link{Oral_2CPT}}, +\code{\link{Oral_2CPTMM}}, \code{\link{Wang2007}}, \code{\link{mavoglurant}}, +\code{\link{neonatal_wt}}, \code{\link{nimoData}}, \code{\link{nmtest}}, \code{\link{pheno_sd}}, diff --git a/man/Bolus_2CPT.Rd b/man/Bolus_2CPT.Rd index 86229af..9cc21d7 100644 --- a/man/Bolus_2CPT.Rd +++ b/man/Bolus_2CPT.Rd @@ -59,20 +59,21 @@ samples in 24 hours per subject, using a first-order absorption, 1-compartment disposition, linear elimination model. } \seealso{ -Other nlmixr2 datasets: -\code{\link{Bolus_1CPTMM}}, +Other nlmixr2 datasets: \code{\link{Bolus_1CPT}}, +\code{\link{Bolus_1CPTMM}}, \code{\link{Bolus_2CPTMM}}, -\code{\link{Infusion_1CPTMM}}, \code{\link{Infusion_1CPT}}, -\code{\link{Infusion_2CPTMM}}, +\code{\link{Infusion_1CPTMM}}, \code{\link{Infusion_2CPT}}, -\code{\link{Oral_1CPTMM}}, +\code{\link{Infusion_2CPTMM}}, \code{\link{Oral_1CPT}}, -\code{\link{Oral_2CPTMM}}, +\code{\link{Oral_1CPTMM}}, \code{\link{Oral_2CPT}}, +\code{\link{Oral_2CPTMM}}, \code{\link{Wang2007}}, \code{\link{mavoglurant}}, +\code{\link{neonatal_wt}}, \code{\link{nimoData}}, \code{\link{nmtest}}, \code{\link{pheno_sd}}, diff --git a/man/Bolus_2CPTMM.Rd b/man/Bolus_2CPTMM.Rd index 8e3be08..9f99650 100644 --- a/man/Bolus_2CPTMM.Rd +++ b/man/Bolus_2CPTMM.Rd @@ -58,20 +58,21 @@ samples in 24 hours per subject, using a first-order absorption, 1-compartment disposition, linear elimination model. } \seealso{ -Other nlmixr2 datasets: -\code{\link{Bolus_1CPTMM}}, +Other nlmixr2 datasets: \code{\link{Bolus_1CPT}}, +\code{\link{Bolus_1CPTMM}}, \code{\link{Bolus_2CPT}}, -\code{\link{Infusion_1CPTMM}}, \code{\link{Infusion_1CPT}}, -\code{\link{Infusion_2CPTMM}}, +\code{\link{Infusion_1CPTMM}}, \code{\link{Infusion_2CPT}}, -\code{\link{Oral_1CPTMM}}, +\code{\link{Infusion_2CPTMM}}, \code{\link{Oral_1CPT}}, -\code{\link{Oral_2CPTMM}}, +\code{\link{Oral_1CPTMM}}, \code{\link{Oral_2CPT}}, +\code{\link{Oral_2CPTMM}}, \code{\link{Wang2007}}, \code{\link{mavoglurant}}, +\code{\link{neonatal_wt}}, \code{\link{nimoData}}, \code{\link{nmtest}}, \code{\link{pheno_sd}}, diff --git a/man/Infusion_1CPT.Rd b/man/Infusion_1CPT.Rd index f914ec3..a8bc125 100644 --- a/man/Infusion_1CPT.Rd +++ b/man/Infusion_1CPT.Rd @@ -58,20 +58,21 @@ samples in 24 hours per subject, using a first-order absorption, 1-compartment disposition, linear elimination model. } \seealso{ -Other nlmixr2 datasets: -\code{\link{Bolus_1CPTMM}}, +Other nlmixr2 datasets: \code{\link{Bolus_1CPT}}, -\code{\link{Bolus_2CPTMM}}, +\code{\link{Bolus_1CPTMM}}, \code{\link{Bolus_2CPT}}, +\code{\link{Bolus_2CPTMM}}, \code{\link{Infusion_1CPTMM}}, -\code{\link{Infusion_2CPTMM}}, \code{\link{Infusion_2CPT}}, -\code{\link{Oral_1CPTMM}}, +\code{\link{Infusion_2CPTMM}}, \code{\link{Oral_1CPT}}, -\code{\link{Oral_2CPTMM}}, +\code{\link{Oral_1CPTMM}}, \code{\link{Oral_2CPT}}, +\code{\link{Oral_2CPTMM}}, \code{\link{Wang2007}}, \code{\link{mavoglurant}}, +\code{\link{neonatal_wt}}, \code{\link{nimoData}}, \code{\link{nmtest}}, \code{\link{pheno_sd}}, diff --git a/man/Infusion_1CPTMM.Rd b/man/Infusion_1CPTMM.Rd index f64bd61..e06809f 100644 --- a/man/Infusion_1CPTMM.Rd +++ b/man/Infusion_1CPTMM.Rd @@ -57,20 +57,21 @@ samples in 24 hours per subject, using a first-order absorption, 1-compartment disposition, linear elimination model. } \seealso{ -Other nlmixr2 datasets: -\code{\link{Bolus_1CPTMM}}, +Other nlmixr2 datasets: \code{\link{Bolus_1CPT}}, -\code{\link{Bolus_2CPTMM}}, +\code{\link{Bolus_1CPTMM}}, \code{\link{Bolus_2CPT}}, +\code{\link{Bolus_2CPTMM}}, \code{\link{Infusion_1CPT}}, -\code{\link{Infusion_2CPTMM}}, \code{\link{Infusion_2CPT}}, -\code{\link{Oral_1CPTMM}}, +\code{\link{Infusion_2CPTMM}}, \code{\link{Oral_1CPT}}, -\code{\link{Oral_2CPTMM}}, +\code{\link{Oral_1CPTMM}}, \code{\link{Oral_2CPT}}, +\code{\link{Oral_2CPTMM}}, \code{\link{Wang2007}}, \code{\link{mavoglurant}}, +\code{\link{neonatal_wt}}, \code{\link{nimoData}}, \code{\link{nmtest}}, \code{\link{pheno_sd}}, diff --git a/man/Infusion_2CPT.Rd b/man/Infusion_2CPT.Rd index 1af4f34..b0d4f26 100644 --- a/man/Infusion_2CPT.Rd +++ b/man/Infusion_2CPT.Rd @@ -60,20 +60,21 @@ samples in 24 hours per subject, using a first-order absorption, 1-compartment disposition, linear elimination model. } \seealso{ -Other nlmixr2 datasets: -\code{\link{Bolus_1CPTMM}}, +Other nlmixr2 datasets: \code{\link{Bolus_1CPT}}, -\code{\link{Bolus_2CPTMM}}, +\code{\link{Bolus_1CPTMM}}, \code{\link{Bolus_2CPT}}, -\code{\link{Infusion_1CPTMM}}, +\code{\link{Bolus_2CPTMM}}, \code{\link{Infusion_1CPT}}, +\code{\link{Infusion_1CPTMM}}, \code{\link{Infusion_2CPTMM}}, -\code{\link{Oral_1CPTMM}}, \code{\link{Oral_1CPT}}, -\code{\link{Oral_2CPTMM}}, +\code{\link{Oral_1CPTMM}}, \code{\link{Oral_2CPT}}, +\code{\link{Oral_2CPTMM}}, \code{\link{Wang2007}}, \code{\link{mavoglurant}}, +\code{\link{neonatal_wt}}, \code{\link{nimoData}}, \code{\link{nmtest}}, \code{\link{pheno_sd}}, diff --git a/man/Infusion_2CPTMM.Rd b/man/Infusion_2CPTMM.Rd index 8c88102..8e04651 100644 --- a/man/Infusion_2CPTMM.Rd +++ b/man/Infusion_2CPTMM.Rd @@ -59,20 +59,21 @@ samples in 24 hours per subject, using a first-order absorption, 1-compartment disposition, linear elimination model. } \seealso{ -Other nlmixr2 datasets: -\code{\link{Bolus_1CPTMM}}, +Other nlmixr2 datasets: \code{\link{Bolus_1CPT}}, -\code{\link{Bolus_2CPTMM}}, +\code{\link{Bolus_1CPTMM}}, \code{\link{Bolus_2CPT}}, -\code{\link{Infusion_1CPTMM}}, +\code{\link{Bolus_2CPTMM}}, \code{\link{Infusion_1CPT}}, +\code{\link{Infusion_1CPTMM}}, \code{\link{Infusion_2CPT}}, -\code{\link{Oral_1CPTMM}}, \code{\link{Oral_1CPT}}, -\code{\link{Oral_2CPTMM}}, +\code{\link{Oral_1CPTMM}}, \code{\link{Oral_2CPT}}, +\code{\link{Oral_2CPTMM}}, \code{\link{Wang2007}}, \code{\link{mavoglurant}}, +\code{\link{neonatal_wt}}, \code{\link{nimoData}}, \code{\link{nmtest}}, \code{\link{pheno_sd}}, diff --git a/man/Oral_1CPT.Rd b/man/Oral_1CPT.Rd index 4591169..39123e3 100644 --- a/man/Oral_1CPT.Rd +++ b/man/Oral_1CPT.Rd @@ -58,20 +58,21 @@ samples in 24 hours per subject, using a first-order absorption, 1-compartment disposition, linear elimination model. } \seealso{ -Other nlmixr2 datasets: -\code{\link{Bolus_1CPTMM}}, +Other nlmixr2 datasets: \code{\link{Bolus_1CPT}}, -\code{\link{Bolus_2CPTMM}}, +\code{\link{Bolus_1CPTMM}}, \code{\link{Bolus_2CPT}}, -\code{\link{Infusion_1CPTMM}}, +\code{\link{Bolus_2CPTMM}}, \code{\link{Infusion_1CPT}}, -\code{\link{Infusion_2CPTMM}}, +\code{\link{Infusion_1CPTMM}}, \code{\link{Infusion_2CPT}}, +\code{\link{Infusion_2CPTMM}}, \code{\link{Oral_1CPTMM}}, -\code{\link{Oral_2CPTMM}}, \code{\link{Oral_2CPT}}, +\code{\link{Oral_2CPTMM}}, \code{\link{Wang2007}}, \code{\link{mavoglurant}}, +\code{\link{neonatal_wt}}, \code{\link{nimoData}}, \code{\link{nmtest}}, \code{\link{pheno_sd}}, diff --git a/man/Oral_1CPTMM.Rd b/man/Oral_1CPTMM.Rd index fa54ca6..57484cc 100644 --- a/man/Oral_1CPTMM.Rd +++ b/man/Oral_1CPTMM.Rd @@ -57,20 +57,21 @@ samples in 24 hours per subject, using a first-order absorption, 1-compartment disposition, linear elimination model. } \seealso{ -Other nlmixr2 datasets: -\code{\link{Bolus_1CPTMM}}, +Other nlmixr2 datasets: \code{\link{Bolus_1CPT}}, -\code{\link{Bolus_2CPTMM}}, +\code{\link{Bolus_1CPTMM}}, \code{\link{Bolus_2CPT}}, -\code{\link{Infusion_1CPTMM}}, +\code{\link{Bolus_2CPTMM}}, \code{\link{Infusion_1CPT}}, -\code{\link{Infusion_2CPTMM}}, +\code{\link{Infusion_1CPTMM}}, \code{\link{Infusion_2CPT}}, +\code{\link{Infusion_2CPTMM}}, \code{\link{Oral_1CPT}}, -\code{\link{Oral_2CPTMM}}, \code{\link{Oral_2CPT}}, +\code{\link{Oral_2CPTMM}}, \code{\link{Wang2007}}, \code{\link{mavoglurant}}, +\code{\link{neonatal_wt}}, \code{\link{nimoData}}, \code{\link{nmtest}}, \code{\link{pheno_sd}}, diff --git a/man/Oral_2CPT.Rd b/man/Oral_2CPT.Rd index 3cc8f38..7c90b8b 100644 --- a/man/Oral_2CPT.Rd +++ b/man/Oral_2CPT.Rd @@ -60,20 +60,21 @@ samples in 24 hours per subject, using a first-order absorption, 1-compartment disposition, linear elimination model. } \seealso{ -Other nlmixr2 datasets: -\code{\link{Bolus_1CPTMM}}, +Other nlmixr2 datasets: \code{\link{Bolus_1CPT}}, -\code{\link{Bolus_2CPTMM}}, +\code{\link{Bolus_1CPTMM}}, \code{\link{Bolus_2CPT}}, -\code{\link{Infusion_1CPTMM}}, +\code{\link{Bolus_2CPTMM}}, \code{\link{Infusion_1CPT}}, -\code{\link{Infusion_2CPTMM}}, +\code{\link{Infusion_1CPTMM}}, \code{\link{Infusion_2CPT}}, -\code{\link{Oral_1CPTMM}}, +\code{\link{Infusion_2CPTMM}}, \code{\link{Oral_1CPT}}, +\code{\link{Oral_1CPTMM}}, \code{\link{Oral_2CPTMM}}, \code{\link{Wang2007}}, \code{\link{mavoglurant}}, +\code{\link{neonatal_wt}}, \code{\link{nimoData}}, \code{\link{nmtest}}, \code{\link{pheno_sd}}, diff --git a/man/Oral_2CPTMM.Rd b/man/Oral_2CPTMM.Rd index b94e79e..e17a3b9 100644 --- a/man/Oral_2CPTMM.Rd +++ b/man/Oral_2CPTMM.Rd @@ -59,20 +59,21 @@ samples in 24 hours per subject, using a first-order absorption, 1-compartment disposition, linear elimination model. } \seealso{ -Other nlmixr2 datasets: -\code{\link{Bolus_1CPTMM}}, +Other nlmixr2 datasets: \code{\link{Bolus_1CPT}}, -\code{\link{Bolus_2CPTMM}}, +\code{\link{Bolus_1CPTMM}}, \code{\link{Bolus_2CPT}}, -\code{\link{Infusion_1CPTMM}}, +\code{\link{Bolus_2CPTMM}}, \code{\link{Infusion_1CPT}}, -\code{\link{Infusion_2CPTMM}}, +\code{\link{Infusion_1CPTMM}}, \code{\link{Infusion_2CPT}}, -\code{\link{Oral_1CPTMM}}, +\code{\link{Infusion_2CPTMM}}, \code{\link{Oral_1CPT}}, +\code{\link{Oral_1CPTMM}}, \code{\link{Oral_2CPT}}, \code{\link{Wang2007}}, \code{\link{mavoglurant}}, +\code{\link{neonatal_wt}}, \code{\link{nimoData}}, \code{\link{nmtest}}, \code{\link{pheno_sd}}, diff --git a/man/Wang2007.Rd b/man/Wang2007.Rd index 350ffda..ff2cdf9 100644 --- a/man/Wang2007.Rd +++ b/man/Wang2007.Rd @@ -25,20 +25,21 @@ estimation methods (Laplace FO, FOCE with and without interaction) are described. } \seealso{ -Other nlmixr2 datasets: -\code{\link{Bolus_1CPTMM}}, +Other nlmixr2 datasets: \code{\link{Bolus_1CPT}}, -\code{\link{Bolus_2CPTMM}}, +\code{\link{Bolus_1CPTMM}}, \code{\link{Bolus_2CPT}}, -\code{\link{Infusion_1CPTMM}}, +\code{\link{Bolus_2CPTMM}}, \code{\link{Infusion_1CPT}}, -\code{\link{Infusion_2CPTMM}}, +\code{\link{Infusion_1CPTMM}}, \code{\link{Infusion_2CPT}}, -\code{\link{Oral_1CPTMM}}, +\code{\link{Infusion_2CPTMM}}, \code{\link{Oral_1CPT}}, -\code{\link{Oral_2CPTMM}}, +\code{\link{Oral_1CPTMM}}, \code{\link{Oral_2CPT}}, +\code{\link{Oral_2CPTMM}}, \code{\link{mavoglurant}}, +\code{\link{neonatal_wt}}, \code{\link{nimoData}}, \code{\link{nmtest}}, \code{\link{pheno_sd}}, diff --git a/man/mavoglurant.Rd b/man/mavoglurant.Rd index cca00f2..b25ec6e 100644 --- a/man/mavoglurant.Rd +++ b/man/mavoglurant.Rd @@ -34,20 +34,21 @@ This was used in a full PBPK model. This one was published for mavoglurant (Wendling et al. 2016). } \seealso{ -Other nlmixr2 datasets: -\code{\link{Bolus_1CPTMM}}, +Other nlmixr2 datasets: \code{\link{Bolus_1CPT}}, -\code{\link{Bolus_2CPTMM}}, +\code{\link{Bolus_1CPTMM}}, \code{\link{Bolus_2CPT}}, -\code{\link{Infusion_1CPTMM}}, +\code{\link{Bolus_2CPTMM}}, \code{\link{Infusion_1CPT}}, -\code{\link{Infusion_2CPTMM}}, +\code{\link{Infusion_1CPTMM}}, \code{\link{Infusion_2CPT}}, -\code{\link{Oral_1CPTMM}}, +\code{\link{Infusion_2CPTMM}}, \code{\link{Oral_1CPT}}, -\code{\link{Oral_2CPTMM}}, +\code{\link{Oral_1CPTMM}}, \code{\link{Oral_2CPT}}, +\code{\link{Oral_2CPTMM}}, \code{\link{Wang2007}}, +\code{\link{neonatal_wt}}, \code{\link{nimoData}}, \code{\link{nmtest}}, \code{\link{pheno_sd}}, diff --git a/man/neonatal_wt.Rd b/man/neonatal_wt.Rd new file mode 100644 index 0000000..7283ba2 --- /dev/null +++ b/man/neonatal_wt.Rd @@ -0,0 +1,62 @@ +% Generated by roxygen2: do not edit by hand +% Please edit documentation in R/data_neonatal_wt.R +\docType{data} +\name{neonatal_wt} +\alias{neonatal_wt} +\title{Neonatal weight progression data} +\format{ +A data frame with 1120 rows by 9 columns + +\describe{ +\item{ID}{Subject ID (189 neonates)} +\item{TIME}{Time since birth (days)} +\item{DV}{Dependent Variable, body weight (g)} +\item{EVID}{rxode2/nlmixr2 event ID (0 = observation; no dosing)} +\item{Sex}{Sex, 0/1} +\item{DelM}{Delivery mode, 0/1} +\item{GA}{Gestational age at birth (weeks)} +\item{Mage}{Maternal age (years)} +\item{Para2}{Parity indicator, 0/1} +} +} +\source{ +Rohleff et al. (2025), CPT: Pharmacometrics & Systems Pharmacology +} +\usage{ +neonatal_wt +} +\description{ +Longitudinal body-weight measurements for a cohort of neonates over roughly +the first week of life, used as the second case study (neonatal weight +progression) in Rohleff et al. (2025) on VAE-based nonlinear mixed-effects +modeling. There is no dosing; body weight follows a turnover (zero-order +production, first-order elimination) growth model whose initial weight is an +estimated parameter, so every record is an observation (\code{EVID = 0}). +} +\seealso{ +Other nlmixr2 datasets: +\code{\link{Bolus_1CPT}}, +\code{\link{Bolus_1CPTMM}}, +\code{\link{Bolus_2CPT}}, +\code{\link{Bolus_2CPTMM}}, +\code{\link{Infusion_1CPT}}, +\code{\link{Infusion_1CPTMM}}, +\code{\link{Infusion_2CPT}}, +\code{\link{Infusion_2CPTMM}}, +\code{\link{Oral_1CPT}}, +\code{\link{Oral_1CPTMM}}, +\code{\link{Oral_2CPT}}, +\code{\link{Oral_2CPTMM}}, +\code{\link{Wang2007}}, +\code{\link{mavoglurant}}, +\code{\link{nimoData}}, +\code{\link{nmtest}}, +\code{\link{pheno_sd}}, +\code{\link{rats}}, +\code{\link{theo_md}}, +\code{\link{theo_sd}}, +\code{\link{warfarin}}, +\code{\link{wbcSim}} +} +\concept{nlmixr2 datasets} +\keyword{datasets} diff --git a/man/nimoData.Rd b/man/nimoData.Rd index 0375dd3..e643f11 100644 --- a/man/nimoData.Rd +++ b/man/nimoData.Rd @@ -33,21 +33,22 @@ nimoData } } \seealso{ -Other nlmixr2 datasets: -\code{\link{Bolus_1CPTMM}}, +Other nlmixr2 datasets: \code{\link{Bolus_1CPT}}, -\code{\link{Bolus_2CPTMM}}, +\code{\link{Bolus_1CPTMM}}, \code{\link{Bolus_2CPT}}, -\code{\link{Infusion_1CPTMM}}, +\code{\link{Bolus_2CPTMM}}, \code{\link{Infusion_1CPT}}, -\code{\link{Infusion_2CPTMM}}, +\code{\link{Infusion_1CPTMM}}, \code{\link{Infusion_2CPT}}, -\code{\link{Oral_1CPTMM}}, +\code{\link{Infusion_2CPTMM}}, \code{\link{Oral_1CPT}}, -\code{\link{Oral_2CPTMM}}, +\code{\link{Oral_1CPTMM}}, \code{\link{Oral_2CPT}}, +\code{\link{Oral_2CPTMM}}, \code{\link{Wang2007}}, \code{\link{mavoglurant}}, +\code{\link{neonatal_wt}}, \code{\link{nmtest}}, \code{\link{pheno_sd}}, \code{\link{rats}}, diff --git a/man/nmtest.Rd b/man/nmtest.Rd index d1e9424..74be5a8 100644 --- a/man/nmtest.Rd +++ b/man/nmtest.Rd @@ -44,21 +44,22 @@ are options to make \code{rxode2}/\code{nlmixr2} behave more like NONMEM. However behaviors we believe are wrong we do not support. } \seealso{ -Other nlmixr2 datasets: -\code{\link{Bolus_1CPTMM}}, +Other nlmixr2 datasets: \code{\link{Bolus_1CPT}}, -\code{\link{Bolus_2CPTMM}}, +\code{\link{Bolus_1CPTMM}}, \code{\link{Bolus_2CPT}}, -\code{\link{Infusion_1CPTMM}}, +\code{\link{Bolus_2CPTMM}}, \code{\link{Infusion_1CPT}}, -\code{\link{Infusion_2CPTMM}}, +\code{\link{Infusion_1CPTMM}}, \code{\link{Infusion_2CPT}}, -\code{\link{Oral_1CPTMM}}, +\code{\link{Infusion_2CPTMM}}, \code{\link{Oral_1CPT}}, -\code{\link{Oral_2CPTMM}}, +\code{\link{Oral_1CPTMM}}, \code{\link{Oral_2CPT}}, +\code{\link{Oral_2CPTMM}}, \code{\link{Wang2007}}, \code{\link{mavoglurant}}, +\code{\link{neonatal_wt}}, \code{\link{nimoData}}, \code{\link{pheno_sd}}, \code{\link{rats}}, diff --git a/man/pheno_sd.Rd b/man/pheno_sd.Rd index d604e2a..f27501c 100644 --- a/man/pheno_sd.Rd +++ b/man/pheno_sd.Rd @@ -48,21 +48,22 @@ analyzed in Boeckmann, Sheiner and Beal (1994), in Davidian and Giltinan (1995), and in Littell et al. (1996). } \seealso{ -Other nlmixr2 datasets: -\code{\link{Bolus_1CPTMM}}, +Other nlmixr2 datasets: \code{\link{Bolus_1CPT}}, -\code{\link{Bolus_2CPTMM}}, +\code{\link{Bolus_1CPTMM}}, \code{\link{Bolus_2CPT}}, -\code{\link{Infusion_1CPTMM}}, +\code{\link{Bolus_2CPTMM}}, \code{\link{Infusion_1CPT}}, -\code{\link{Infusion_2CPTMM}}, +\code{\link{Infusion_1CPTMM}}, \code{\link{Infusion_2CPT}}, -\code{\link{Oral_1CPTMM}}, +\code{\link{Infusion_2CPTMM}}, \code{\link{Oral_1CPT}}, -\code{\link{Oral_2CPTMM}}, +\code{\link{Oral_1CPTMM}}, \code{\link{Oral_2CPT}}, +\code{\link{Oral_2CPTMM}}, \code{\link{Wang2007}}, \code{\link{mavoglurant}}, +\code{\link{neonatal_wt}}, \code{\link{nimoData}}, \code{\link{nmtest}}, \code{\link{rats}}, diff --git a/man/rats.Rd b/man/rats.Rd index baecd70..5510786 100644 --- a/man/rats.Rd +++ b/man/rats.Rd @@ -48,21 +48,22 @@ Ochi, Y. and Prentice, R. L. (1984), Biometrika, 71, 531-543. } \seealso{ -Other nlmixr2 datasets: -\code{\link{Bolus_1CPTMM}}, +Other nlmixr2 datasets: \code{\link{Bolus_1CPT}}, -\code{\link{Bolus_2CPTMM}}, +\code{\link{Bolus_1CPTMM}}, \code{\link{Bolus_2CPT}}, -\code{\link{Infusion_1CPTMM}}, +\code{\link{Bolus_2CPTMM}}, \code{\link{Infusion_1CPT}}, -\code{\link{Infusion_2CPTMM}}, +\code{\link{Infusion_1CPTMM}}, \code{\link{Infusion_2CPT}}, -\code{\link{Oral_1CPTMM}}, +\code{\link{Infusion_2CPTMM}}, \code{\link{Oral_1CPT}}, -\code{\link{Oral_2CPTMM}}, +\code{\link{Oral_1CPTMM}}, \code{\link{Oral_2CPT}}, +\code{\link{Oral_2CPTMM}}, \code{\link{Wang2007}}, \code{\link{mavoglurant}}, +\code{\link{neonatal_wt}}, \code{\link{nimoData}}, \code{\link{nmtest}}, \code{\link{pheno_sd}}, diff --git a/man/theo_md.Rd b/man/theo_md.Rd index cea50fe..3e3940c 100644 --- a/man/theo_md.Rd +++ b/man/theo_md.Rd @@ -30,21 +30,22 @@ concentrations were simulated with once a day regimen for 7 days (QD). } \seealso{ -Other nlmixr2 datasets: -\code{\link{Bolus_1CPTMM}}, +Other nlmixr2 datasets: \code{\link{Bolus_1CPT}}, -\code{\link{Bolus_2CPTMM}}, +\code{\link{Bolus_1CPTMM}}, \code{\link{Bolus_2CPT}}, -\code{\link{Infusion_1CPTMM}}, +\code{\link{Bolus_2CPTMM}}, \code{\link{Infusion_1CPT}}, -\code{\link{Infusion_2CPTMM}}, +\code{\link{Infusion_1CPTMM}}, \code{\link{Infusion_2CPT}}, -\code{\link{Oral_1CPTMM}}, +\code{\link{Infusion_2CPTMM}}, \code{\link{Oral_1CPT}}, -\code{\link{Oral_2CPTMM}}, +\code{\link{Oral_1CPTMM}}, \code{\link{Oral_2CPT}}, +\code{\link{Oral_2CPTMM}}, \code{\link{Wang2007}}, \code{\link{mavoglurant}}, +\code{\link{neonatal_wt}}, \code{\link{nimoData}}, \code{\link{nmtest}}, \code{\link{pheno_sd}}, diff --git a/man/theo_sd.Rd b/man/theo_sd.Rd index 1fdb089..7470171 100644 --- a/man/theo_sd.Rd +++ b/man/theo_sd.Rd @@ -28,21 +28,22 @@ This data set is the day 1 concentrations of the theophylline data that is included in the nlme/NONMEM. } \seealso{ -Other nlmixr2 datasets: -\code{\link{Bolus_1CPTMM}}, +Other nlmixr2 datasets: \code{\link{Bolus_1CPT}}, -\code{\link{Bolus_2CPTMM}}, +\code{\link{Bolus_1CPTMM}}, \code{\link{Bolus_2CPT}}, -\code{\link{Infusion_1CPTMM}}, +\code{\link{Bolus_2CPTMM}}, \code{\link{Infusion_1CPT}}, -\code{\link{Infusion_2CPTMM}}, +\code{\link{Infusion_1CPTMM}}, \code{\link{Infusion_2CPT}}, -\code{\link{Oral_1CPTMM}}, +\code{\link{Infusion_2CPTMM}}, \code{\link{Oral_1CPT}}, -\code{\link{Oral_2CPTMM}}, +\code{\link{Oral_1CPTMM}}, \code{\link{Oral_2CPT}}, +\code{\link{Oral_2CPTMM}}, \code{\link{Wang2007}}, \code{\link{mavoglurant}}, +\code{\link{neonatal_wt}}, \code{\link{nimoData}}, \code{\link{nmtest}}, \code{\link{pheno_sd}}, diff --git a/man/warfarin.Rd b/man/warfarin.Rd index 1de6340..5b28d5a 100644 --- a/man/warfarin.Rd +++ b/man/warfarin.Rd @@ -39,21 +39,22 @@ Initiation of warfarin therapy without a loading dose. Circulation 1968; 38: 169-177. } \seealso{ -Other nlmixr2 datasets: -\code{\link{Bolus_1CPTMM}}, +Other nlmixr2 datasets: \code{\link{Bolus_1CPT}}, -\code{\link{Bolus_2CPTMM}}, +\code{\link{Bolus_1CPTMM}}, \code{\link{Bolus_2CPT}}, -\code{\link{Infusion_1CPTMM}}, +\code{\link{Bolus_2CPTMM}}, \code{\link{Infusion_1CPT}}, -\code{\link{Infusion_2CPTMM}}, +\code{\link{Infusion_1CPTMM}}, \code{\link{Infusion_2CPT}}, -\code{\link{Oral_1CPTMM}}, +\code{\link{Infusion_2CPTMM}}, \code{\link{Oral_1CPT}}, -\code{\link{Oral_2CPTMM}}, +\code{\link{Oral_1CPTMM}}, \code{\link{Oral_2CPT}}, +\code{\link{Oral_2CPTMM}}, \code{\link{Wang2007}}, \code{\link{mavoglurant}}, +\code{\link{neonatal_wt}}, \code{\link{nimoData}}, \code{\link{nmtest}}, \code{\link{pheno_sd}}, diff --git a/man/wbcSim.Rd b/man/wbcSim.Rd index 83023c7..dc849cc 100644 --- a/man/wbcSim.Rd +++ b/man/wbcSim.Rd @@ -28,21 +28,22 @@ wbcSim } } \seealso{ -Other nlmixr2 datasets: -\code{\link{Bolus_1CPTMM}}, +Other nlmixr2 datasets: \code{\link{Bolus_1CPT}}, -\code{\link{Bolus_2CPTMM}}, +\code{\link{Bolus_1CPTMM}}, \code{\link{Bolus_2CPT}}, -\code{\link{Infusion_1CPTMM}}, +\code{\link{Bolus_2CPTMM}}, \code{\link{Infusion_1CPT}}, -\code{\link{Infusion_2CPTMM}}, +\code{\link{Infusion_1CPTMM}}, \code{\link{Infusion_2CPT}}, -\code{\link{Oral_1CPTMM}}, +\code{\link{Infusion_2CPTMM}}, \code{\link{Oral_1CPT}}, -\code{\link{Oral_2CPTMM}}, +\code{\link{Oral_1CPTMM}}, \code{\link{Oral_2CPT}}, +\code{\link{Oral_2CPTMM}}, \code{\link{Wang2007}}, \code{\link{mavoglurant}}, +\code{\link{neonatal_wt}}, \code{\link{nimoData}}, \code{\link{nmtest}}, \code{\link{pheno_sd}},