Hi,
This may be a naive question - Is the pseudotime information absolutely required for IReNA analysis? I'm interested in inferring cell-type-specific regulatory networks from a heterogeneous population (e.g. tumor microenvironment). I do not expect one cell type will progress to another cell type, so it doesn't make sense to me to reconstruct the trajectory. Would you please give me some advice?
Thanks!
Hi,
This may be a naive question - Is the pseudotime information absolutely required for IReNA analysis? I'm interested in inferring cell-type-specific regulatory networks from a heterogeneous population (e.g. tumor microenvironment). I do not expect one cell type will progress to another cell type, so it doesn't make sense to me to reconstruct the trajectory. Would you please give me some advice?
Thanks!