diff --git a/pyproject.toml b/pyproject.toml
index 8d3798b8..fdf34ccb 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -21,7 +21,7 @@ classifiers = [
   "Topic :: Security :: Cryptography",
   "Topic :: Software Development :: Libraries :: Python Modules",
 ]
-dependencies = ["cryptography (>=2.6, !=35, <49)"]
+dependencies = ["cryptography (>=45, <49)"]
 
 [project.optional-dependencies]
 pcsc = ["pyscard (>=1.9, <3)"]