diff --git a/empty-base.json b/empty-base.json
index 0a64387..30b9d7e 100644
--- a/empty-base.json
+++ b/empty-base.json
@@ -19,12 +19,12 @@
         "val" : "EMPTY by NDI is licensed under CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/). You are free to share (copy and redistribute the material in any medium or format) and adapt (remix, transform, and build upon the material) for any purpose, even commercially. You must give appropriate credit (by using the original ontology IRI for the whole ontology or original term IRIs for individual terms), provide a link to the license, and indicate if any changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use."
       }, {
         "pred" : "http://www.w3.org/2002/07/owl#versionInfo",
-        "val" : "2026-02-23"
+        "val" : "2026-04-04"
       }, {
         "pred" : "http://www.w3.org/2002/07/owl#versionInfo",
         "val" : "Release 2025-07-10"
       } ],
-      "version" : "http://purl.obolibrary.org/obo/empty/releases/2026-02-23/empty-base.json"
+      "version" : "http://purl.obolibrary.org/obo/empty/releases/2026-04-04/empty-base.json"
     },
     "nodes" : [ {
       "id" : "http://purl.obolibrary.org/obo/EMPTY_0000001",
@@ -77,7 +77,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's body (typically defined by its center point or a significant portion) fully enters the user-defined zone designated as 'Open Arm (North)'. The 'Open Arm (North)' is one of the two open arms, distinguished by its assigned 'north' orientation or designation in the experimental setup. Unit of measure: count"
+          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's body (typically defined by its center point or a significant portion) fully enters the user-defined zone designated as 'Open Arm (North)'. The 'Open Arm (North)' is one of the two open arms, distinguished by its assigned 'north' orientation or designation in the experimental setup. Unit: count"
         }
       }
     }, {
@@ -86,7 +86,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's body (typically defined by its center point or a significant portion) fully enters the user-defined zone designated as 'Open Arm (South)'. The 'Open Arm (South)' is one of the two open arms, distinguished by its assigned 'south' orientation or designation in the experimental setup. Unit of measure: count"
+          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's body (typically defined by its center point or a significant portion) fully enters the user-defined zone designated as 'Open Arm (South)'. The 'Open Arm (South)' is one of the two open arms, distinguished by its assigned 'south' orientation or designation in the experimental setup. Unit: count"
         }
       }
     }, {
@@ -95,7 +95,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this represents the total number of times the animal's body (typically defined by its center point or a significant portion) fully enters the designated open arm zones (e.g., 'Open Arm (North)' and 'Open Arm (South)'). It is a common measure of exploration and anxiety. Unit of measure: count"
+          "val" : "In the Elevated Plus Maze task, this represents the total number of times the animal's body (typically defined by its center point or a significant portion) fully enters the designated open arm zones (e.g., 'Open Arm (North)' and 'Open Arm (South)'). It is a common measure of exploration and anxiety. Unit: count"
         }
       }
     }, {
@@ -104,7 +104,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's head (specifically tracked by the software) enters the user-defined 'Open Arm (North)' zone, irrespective of full body entry. This can indicate risk assessment or tentative exploration of the arm designated as 'north'. Unit of measure: count"
+          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's head (specifically tracked by the software) enters the user-defined 'Open Arm (North)' zone, irrespective of full body entry. This can indicate risk assessment or tentative exploration of the arm designated as 'north'. Unit: count"
         }
       }
     }, {
@@ -113,7 +113,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's head (specifically tracked by the software) enters the user-defined 'Open Arm (South)' zone, irrespective of full body entry, often reflecting cautious exploration of the open arm designated as 'south'. Unit of measure: count"
+          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's head (specifically tracked by the software) enters the user-defined 'Open Arm (South)' zone, irrespective of full body entry, often reflecting cautious exploration of the open arm designated as 'south'. Unit: count"
         }
       }
     }, {
@@ -122,7 +122,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this is the total number of times the animal's head (specifically tracked by the software) enters any of the designated open arm zones (e.g., 'Open Arm (North)' and 'Open Arm (South)'), considered an indicator of risk-assessment behavior. Unit of measure: count"
+          "val" : "In the Elevated Plus Maze task, this is the total number of times the animal's head (specifically tracked by the software) enters any of the designated open arm zones (e.g., 'Open Arm (North)' and 'Open Arm (South)'), considered an indicator of risk-assessment behavior. Unit: count"
         }
       }
     }, {
@@ -131,7 +131,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Open Arm (North)' zone. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Open Arm (North)' zone. Unit: seconds"
         }
       }
     }, {
@@ -140,7 +140,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Open Arm (South)' zone. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Open Arm (South)' zone. Unit: seconds"
         }
       }
     }, {
@@ -149,7 +149,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this is the cumulative total duration the animal's body spends within any of the designated open arm zones (e.g., 'Open Arm (North)' and 'Open Arm (South)'). Less time is generally indicative of higher anxiety. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this is the cumulative total duration the animal's body spends within any of the designated open arm zones (e.g., 'Open Arm (North)' and 'Open Arm (South)'). Less time is generally indicative of higher anxiety. Unit: seconds"
         }
       }
     }, {
@@ -158,7 +158,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this represents the percentage of the total test duration that the animal spends in any of the designated open arm zones (e.g., 'Open Arm (North)' and 'Open Arm (South)'). Unit of measure: %"
+          "val" : "In the Elevated Plus Maze task, this represents the percentage of the total test duration that the animal spends in any of the designated open arm zones (e.g., 'Open Arm (North)' and 'Open Arm (South)'). Unit: %"
         }
       }
     }, {
@@ -167,7 +167,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Open Arm (North)' zone. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Open Arm (North)' zone. Unit: seconds"
         }
       }
     }, {
@@ -176,7 +176,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Open Arm (South)' zone. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Open Arm (South)' zone. Unit: seconds"
         }
       }
     }, {
@@ -185,7 +185,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into any of the designated open arm zones (e.g., 'Open Arm (North)' or 'Open Arm (South)'). Longer latencies often suggest higher anxiety. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into any of the designated open arm zones (e.g., 'Open Arm (North)' or 'Open Arm (South)'). Longer latencies often suggest higher anxiety. Unit: seconds"
         }
       }
     }, {
@@ -194,7 +194,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Open Arm (North)' zone, as detected by the tracking software. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Open Arm (North)' zone, as detected by the tracking software. Unit: seconds"
         }
       }
     }, {
@@ -203,7 +203,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Open Arm (South)' zone, as detected by the tracking software. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Open Arm (South)' zone, as detected by the tracking software. Unit: seconds"
         }
       }
     }, {
@@ -212,7 +212,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this is the cumulative duration the animal spends actively moving towards any of the designated open arm zones (e.g., 'Open Arm (North)' or 'Open Arm (South)'), reflecting approach motivation. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this is the cumulative duration the animal spends actively moving towards any of the designated open arm zones (e.g., 'Open Arm (North)' or 'Open Arm (South)'), reflecting approach motivation. Unit: seconds"
         }
       }
     }, {
@@ -221,7 +221,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior (a state of immobility except for respiratory movements) while within the user-defined 'Open Arm (North)' zone. Freezing is a common fear response. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior (a state of immobility except for respiratory movements) while within the user-defined 'Open Arm (North)' zone. Freezing is a common fear response. Unit: seconds"
         }
       }
     }, {
@@ -230,7 +230,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined 'Open Arm (South)' zone. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined 'Open Arm (South)' zone. Unit: seconds"
         }
       }
     }, {
@@ -239,7 +239,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this is the cumulative duration the animal exhibits freezing behavior while within any of the designated open arm zones (e.g., 'Open Arm (North)' or 'Open Arm (South)'), indicating fear or anxiety. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this is the cumulative duration the animal exhibits freezing behavior while within any of the designated open arm zones (e.g., 'Open Arm (North)' or 'Open Arm (South)'), indicating fear or anxiety. Unit: seconds"
         }
       }
     }, {
@@ -248,7 +248,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's body fully enters the user-defined 'Closed Arm (West)' zone, representing the enclosed arm designated as 'west'. Unit of measure: count"
+          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's body fully enters the user-defined 'Closed Arm (West)' zone, representing the enclosed arm designated as 'west'. Unit: count"
         }
       }
     }, {
@@ -257,7 +257,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's body fully enters the user-defined 'Closed Arm (East)' zone, representing the enclosed arm designated as 'east'. Unit of measure: count"
+          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's body fully enters the user-defined 'Closed Arm (East)' zone, representing the enclosed arm designated as 'east'. Unit: count"
         }
       }
     }, {
@@ -266,7 +266,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this is the total number of times the animal's body fully enters any of the designated closed arm zones (e.g., 'Closed Arm (West)' and 'Closed Arm (East)'). It is often used as an indicator of general locomotor activity. Unit of measure: count"
+          "val" : "In the Elevated Plus Maze task, this is the total number of times the animal's body fully enters any of the designated closed arm zones (e.g., 'Closed Arm (West)' and 'Closed Arm (East)'). It is often used as an indicator of general locomotor activity. Unit: count"
         }
       }
     }, {
@@ -275,7 +275,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's head enters the user-defined 'Closed Arm (West)' zone. Unit of measure: count"
+          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's head enters the user-defined 'Closed Arm (West)' zone. Unit: count"
         }
       }
     }, {
@@ -284,7 +284,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's head enters the user-defined 'Closed Arm (East)' zone. Unit of measure: count"
+          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's head enters the user-defined 'Closed Arm (East)' zone. Unit: count"
         }
       }
     }, {
@@ -293,7 +293,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this is the total number of times the animal's head enters any of the designated closed arm zones (e.g., 'Closed Arm (West)' and 'Closed Arm (East)'). Unit of measure: count"
+          "val" : "In the Elevated Plus Maze task, this is the total number of times the animal's head enters any of the designated closed arm zones (e.g., 'Closed Arm (West)' and 'Closed Arm (East)'). Unit: count"
         }
       }
     }, {
@@ -302,7 +302,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Closed Arm (West)' zone. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Closed Arm (West)' zone. Unit: seconds"
         }
       }
     }, {
@@ -311,7 +311,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Closed Arm (East)' zone. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Closed Arm (East)' zone. Unit: seconds"
         }
       }
     }, {
@@ -320,7 +320,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this is the cumulative total duration the animal's body spends within any of the designated closed arm zones (e.g., 'Closed Arm (West)' and 'Closed Arm (East)'). Animals typically spend more time in these 'safer' areas. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this is the cumulative total duration the animal's body spends within any of the designated closed arm zones (e.g., 'Closed Arm (West)' and 'Closed Arm (East)'). Animals typically spend more time in these 'safer' areas. Unit: seconds"
         }
       }
     }, {
@@ -329,7 +329,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this represents the percentage of the total test duration that the animal spends in any of the designated closed arm zones (e.g., 'Closed Arm (West)' and 'Closed Arm (East)'). Unit of measure: %"
+          "val" : "In the Elevated Plus Maze task, this represents the percentage of the total test duration that the animal spends in any of the designated closed arm zones (e.g., 'Closed Arm (West)' and 'Closed Arm (East)'). Unit: %"
         }
       }
     }, {
@@ -338,7 +338,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Closed Arm (West)' zone. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Closed Arm (West)' zone. Unit: seconds"
         }
       }
     }, {
@@ -347,7 +347,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Closed Arm (East)' zone. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Closed Arm (East)' zone. Unit: seconds"
         }
       }
     }, {
@@ -356,7 +356,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into any of the designated closed arm zones (e.g., 'Closed Arm (West)' or 'Closed Arm (East)'). Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into any of the designated closed arm zones (e.g., 'Closed Arm (West)' or 'Closed Arm (East)'). Unit: seconds"
         }
       }
     }, {
@@ -365,7 +365,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Closed Arm (West)' zone. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Closed Arm (West)' zone. Unit: seconds"
         }
       }
     }, {
@@ -374,7 +374,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Closed Arm (East)' zone. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Closed Arm (East)' zone. Unit: seconds"
         }
       }
     }, {
@@ -383,7 +383,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this is the cumulative duration the animal spends actively moving towards any of the designated closed arm zones (e.g., 'Closed Arm (West)' or 'Closed Arm (East)'). Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this is the cumulative duration the animal spends actively moving towards any of the designated closed arm zones (e.g., 'Closed Arm (West)' or 'Closed Arm (East)'). Unit: seconds"
         }
       }
     }, {
@@ -392,7 +392,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined 'Closed Arm (West)' zone. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined 'Closed Arm (West)' zone. Unit: seconds"
         }
       }
     }, {
@@ -401,7 +401,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined 'Closed Arm (East)' zone. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined 'Closed Arm (East)' zone. Unit: seconds"
         }
       }
     }, {
@@ -410,7 +410,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this is the cumulative duration the animal exhibits freezing behavior while within any of the designated closed arm zones (e.g., 'Closed Arm (West)' or 'Closed Arm (East)'). Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this is the cumulative duration the animal exhibits freezing behavior while within any of the designated closed arm zones (e.g., 'Closed Arm (West)' or 'Closed Arm (East)'). Unit: seconds"
         }
       }
     }, {
@@ -419,7 +419,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's body fully enters the user-defined 'Center' zone of the maze, typically from one of the arms. The center zone is the area where all four arms meet. Unit of measure: count"
+          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's body fully enters the user-defined 'Center' zone of the maze, typically from one of the arms. The center zone is the area where all four arms meet. Unit: count"
         }
       }
     }, {
@@ -428,7 +428,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's head enters the user-defined 'Center' zone of the maze. Unit of measure: count"
+          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's head enters the user-defined 'Center' zone of the maze. Unit: count"
         }
       }
     }, {
@@ -437,7 +437,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Center' zone. Time in the center can indicate decision-making or risk assessment. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Center' zone. Time in the center can indicate decision-making or risk assessment. Unit: seconds"
         }
       }
     }, {
@@ -446,7 +446,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this represents the percentage of the total test duration that the animal spends in the user-defined 'Center' zone of the maze. Unit of measure: %"
+          "val" : "In the Elevated Plus Maze task, this represents the percentage of the total test duration that the animal spends in the user-defined 'Center' zone of the maze. Unit: %"
         }
       }
     }, {
@@ -455,7 +455,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Center' zone. If the animal starts in the center, this value may be zero or not applicable. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Center' zone. If the animal starts in the center, this value may be zero or not applicable. Unit: seconds"
         }
       }
     }, {
@@ -464,7 +464,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Center' zone of the maze (e.g., from an arm). Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Center' zone of the maze (e.g., from an arm). Unit: seconds"
         }
       }
     }, {
@@ -473,7 +473,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined 'Center' zone of the maze. Freezing in this relatively exposed area can indicate high anxiety. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined 'Center' zone of the maze. Freezing in this relatively exposed area can indicate high anxiety. Unit: seconds"
         }
       }
     }, {
@@ -500,7 +500,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Fear-potentiated startle paradigm, this is the amplitude of the acoustic startle response (ASR) measured in response to a startle-eliciting stimulus (e.g., 95-dB white noise burst) prior to any fear conditioning procedures, typically assessed during habituation or pre-conditioning phase. This measurement serves as a reference point for later comparisons with post-conditioning startle responses. Unit of measure: arbitrary units or standardized score."
+          "val" : "In the Fear-potentiated startle paradigm, this is the amplitude of the acoustic startle response (ASR) measured in response to a startle-eliciting stimulus (e.g., 95-dB white noise burst) prior to any fear conditioning procedures, typically assessed during habituation or pre-conditioning phase. This measurement serves as a reference point for later comparisons with post-conditioning startle responses. Unit: arbitrary units or standardized score."
         }
       }
     }, {
@@ -545,7 +545,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "Identifier for the specific Plexiglas enclosure or sound-attenuating chamber within the Fear-Potentiated Startle (FPS) apparatus (e.g., San Diego Instruments SR-Lab) in which a subject was tested for a given trial. Unit of measure: count or identifier string"
+          "val" : "Identifier for the specific Plexiglas enclosure or sound-attenuating chamber within the Fear-Potentiated Startle (FPS) apparatus (e.g., San Diego Instruments SR-Lab) in which a subject was tested for a given trial. Unit: count or identifier string"
         }
       }
     }, {
@@ -563,7 +563,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "The total number of data points (samples) recorded and analyzed for a single acoustic startle response, typically within a defined time window following stimulus onset (e.g., a 200-ms window as mentioned in the manuscript). Unit of measure: count"
+          "val" : "The total number of data points (samples) recorded and analyzed for a single acoustic startle response, typically within a defined time window following stimulus onset (e.g., a 200-ms window as mentioned in the manuscript). Unit: count"
         }
       }
     }, {
@@ -572,7 +572,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "The rate at which the analog startle response signal was digitized during data acquisition. Unit of measure: Hertz (Hz)"
+          "val" : "The rate at which the analog startle response signal was digitized during data acquisition. Unit: Hertz (Hz)"
         }
       }
     }, {
@@ -581,7 +581,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "The amplitude of the digitized acoustic startle response signal at the very beginning (onset) of the defined analysis window (e.g., a 200-ms window) used to quantify the reflex. Unit of measure: millivolts (mV) or arbitrary units based on transducer calibration."
+          "val" : "The amplitude of the digitized acoustic startle response signal at the very beginning (onset) of the defined analysis window (e.g., a 200-ms window) used to quantify the reflex. Unit: millivolts (mV) or arbitrary units based on transducer calibration."
         }
       }
     }, {
@@ -590,7 +590,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "The peak amplitude of the acoustic startle response (e.g., 'jump amplitude') detected within the defined analysis window (e.g., 200-ms window) for a given trial. Unit of measure: millivolts (mV) or arbitrary units."
+          "val" : "The peak amplitude of the acoustic startle response (e.g., 'jump amplitude') detected within the defined analysis window (e.g., 200-ms window) for a given trial. Unit: millivolts (mV) or arbitrary units."
         }
       }
     }, {
@@ -599,7 +599,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "The latency from the onset of the startle-eliciting stimulus (or the beginning of the analysis window) to the occurrence of the maximum (peak) amplitude of the acoustic startle response. Unit of measure: milliseconds (ms)"
+          "val" : "The latency from the onset of the startle-eliciting stimulus (or the beginning of the analysis window) to the occurrence of the maximum (peak) amplitude of the acoustic startle response. Unit: milliseconds (ms)"
         }
       }
     }, {
@@ -608,7 +608,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "The average amplitude of the digitized acoustic startle response signal calculated across the entire duration of the defined analysis window (e.g., 200-ms window). Unit of measure: millivolts (mV) or arbitrary units."
+          "val" : "The average amplitude of the digitized acoustic startle response signal calculated across the entire duration of the defined analysis window (e.g., 200-ms window). Unit: millivolts (mV) or arbitrary units."
         }
       }
     }, {
@@ -635,7 +635,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this is the time of the total test duration in seconds'). Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this is the time of the total test duration in seconds'). Unit: seconds"
         }
       }
     }, {
@@ -1612,7 +1612,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "The number of seconds the individual spent freezing during a given period of time. Unit of measure: seconds"
+          "val" : "The number of seconds the individual spent freezing during a given period of time. Unit: seconds"
         }
       }
     }, {
@@ -1621,7 +1621,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the contextual fear conditioning paradigm, this is the time of the block duration in seconds. Unit of measure: seconds"
+          "val" : "In the contextual fear conditioning paradigm, this is the time of the block duration in seconds. Unit: seconds"
         }
       }
     }, {
@@ -2099,12 +2099,274 @@
           "val" : "A digital file for which the format, encoding, or origin cannot be definitively identified by the system or investigator, necessitating further manual review or specialized software for interpretation."
         }
       }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000231",
+      "lbl" : "C. elegans chemotaxis assay parameter",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "A parameter that specifies the technical settings, environmental conditions, or experimental design of a chemotaxis assay involving Caenorhabditis elegans."
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000232",
+      "lbl" : "C. elegans chemotaxis assay parameter: chemoattractant mixture table",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "A table containing the quantities and identities of all chemicals used as a chemoattractant (e.g., isoamyl alcohol, diacetyl) to elicit a directed movement response in C. elegans."
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000233",
+      "lbl" : "C. elegans chemotaxis assay parameter: chemoattractant mixture volume",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "The volume of the chemoattractant mixture pipetted onto the agar plate in a chemotaxis assay. Unit: microliters (μL)."
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000234",
+      "lbl" : "C. elegans chemotaxis assay parameter: assay duration",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "The total time elapsed from the point at which C. elegans are placed on the assay plate until the movement is arrested or the final positions are recorded. Unit: minutes."
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000235",
+      "lbl" : "C. elegans chemotaxis assay measurement",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "A quantitative or qualitative value derived from a C. elegans chemotaxis assay, typically describing the efficiency or directionality of the animals' movement toward or away from a chemical source."
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000236",
+      "lbl" : "C. elegans chemotaxis assay measurement: McCutcheon index",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "A behavioral measurement of chemotactic efficiency defined as the ratio of the straight-line displacement toward the attractant to the total path length traveled by the organism. Values range from -1 to 1."
+        },
+        "synonyms" : [ {
+          "pred" : "hasExactSynonym",
+          "val" : "chemotactic ratio"
+        } ]
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000237",
+      "lbl" : "C. elegans chemotaxis assay measurement: mean velocity",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "The average speed of a C. elegans individual or population during the duration of the chemotaxis assay. Unit: micrometers per second (µm/s)."
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000238",
+      "lbl" : "investigator-defined strain",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "A specific genetic variant or line of an organism designated by the investigator, often containing unique mutations, transgenes, or genomic edits not yet categorized in a public repository."
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000239",
+      "lbl" : "C. elegans strain",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "A specific strain of Caenorhabditis elegans, identified by its genotype or a standard nomenclature (e.g., N2, CB4856), used in experimental procedures."
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000240",
+      "lbl" : "BAB9001",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "A C. elegans strain with the genotype daf-22 (m130). This strain was originally obtained from the Caenorhabditis Genetics Center (CGC) as strain DR476 and subsequently outcrossed three times. [Source: https://doi.org/TBD]"
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000241",
+      "lbl" : "BAB9002",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "A C. elegans klp-6 rescue strain with the genotype klp-6 (my8); Pklp-6::GFP::KLP-6 (array, IndEx 9002). [Source: https://doi.org/TBD]"
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000242",
+      "lbl" : "TM5848",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "A C. elegans strain with the genotype cil-7 (tm5848) I, exhibiting a him phenotype. This strain was obtained from the National BioResource Project (NBRP), Japan. [Source: https://doi.org/TBD]"
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000243",
+      "lbl" : "PT3602",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "A C. elegans strain with the genotype cil-7 (my61[cil-7::mNG])I; him-5(e1490) V. This strain was provided as a gift from the Maureen Barr lab. [Source: https://doi.org/TBD]"
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000244",
+      "lbl" : "BAB9003",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "A C. elegans strain with the genotype PT3602; Pnlp-43_hCaspase nZ (array IndEx 9003). [Source: https://doi.org/TBD]"
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000245",
+      "lbl" : "BAB9004",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "A C. elegans strain with the genotype PT3602; Pklp-6_hCaspase Cz (array IndEx 9004). [Source: https://doi.org/TBD]"
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000246",
+      "lbl" : "BAB9005",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "A C. elegans strain with the genotype PT3602; Pnlp-43_hCaspase nZ (array IndEx 9003) and Pklp-6_hCaspase Cz (array IndEx 9004). [Source: https://doi.org/TBD]"
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000247",
+      "lbl" : "fluorescence imaging measurement",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "fluorescence imaging measurement"
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000248",
+      "lbl" : "mean fluorescence intensity",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "Mean fluorescence intensity. Unit: arbitrary units (AU)"
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000249",
+      "lbl" : "fluorescent punctal count",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "A quantitative measurement of the number of distinct fluorescent spots or puncta detected within a defined region of interest in a fluorescence image. Unit: count"
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000250",
+      "lbl" : "fluorescence imaging parameter",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "A specific parameter related to fluorescence imaging acquisition or assay."
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000251",
+      "lbl" : "fluorescence target ontology identifier",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "fluorescence target ontology identifier"
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000252",
+      "lbl" : "fluorescence target name",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "fluorescence target name"
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000253",
+      "lbl" : "SnapGene file format",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "A .dna file format designed for storing annotated DNA sequences, including linear/circular topology, features, primers, and enzyme sites."
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000254",
+      "lbl" : "Escherichia coli OP50: heat-killed",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "A preparation of Escherichia coli strain OP50 that has been rendered non-viable through the application of heat, typically used as a non-proliferating food source in C. elegans assays."
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000255",
+      "lbl" : "C. elegans transfer method: M9 buffer wash",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "Method used to transfer C. elegans whereby an M9 buffer is used to wash C. elegans off of an agar plate. Animals can then be transferred using a piper."
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000256",
+      "lbl" : "C. elegans transfer method: titanium pick",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "Method used to transfer C. elegans whereby a titanium pick is used to scoop animals off of an agar plate."
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000257",
+      "lbl" : "C. elegans chemotaxis assay: video recording",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "A video recording capturing the behavior of C. elegans during a chemotaxis assay."
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000258",
+      "lbl" : "fluorescence imaging data",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "An image or video acquired using fluorescence microscopy."
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/NCBITaxon_637912",
+      "type" : "CLASS"
     }, {
       "id" : "http://purl.obolibrary.org/obo/NCIT_C14184",
       "type" : "CLASS"
     }, {
       "id" : "http://purl.obolibrary.org/obo/NCIT_C14240",
       "type" : "CLASS"
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/NCIT_C16856",
+      "type" : "CLASS"
     }, {
       "id" : "http://purl.obolibrary.org/obo/NCIT_C172272",
       "type" : "CLASS"
@@ -2192,6 +2454,9 @@
     }, {
       "id" : "http://purl.obolibrary.org/obo/UBERON_0003883",
       "type" : "CLASS"
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/format_1929",
+      "type" : "CLASS"
     }, {
       "id" : "http://purl.obolibrary.org/obo/IAO_0000115",
       "type" : "PROPERTY",
@@ -3569,6 +3834,118 @@
       "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000230",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/NCIT_C172272"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000231",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000101"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000232",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000231"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000233",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000231"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000234",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000231"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000235",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000100"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000236",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000235"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000237",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000235"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000238",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000076"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000239",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000238"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000240",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000239"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000241",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000239"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000242",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000239"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000243",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000239"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000244",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000239"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000245",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000239"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000246",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000239"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000247",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000001"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000248",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000247"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000249",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000247"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000250",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000080"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000251",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000250"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000252",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000250"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000253",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/format_1929"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000254",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_637912"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000255",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000189"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000256",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000189"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000257",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000129"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000258",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/NCIT_C16856"
     } ],
     "equivalentNodesSets" : [ {
       "representativeNodeId" : "http://purl.obolibrary.org/obo/EMPTY_0000179",
diff --git a/empty-base.obo b/empty-base.obo
index 714bf3b..75a4db3 100644
--- a/empty-base.obo
+++ b/empty-base.obo
@@ -1,5 +1,5 @@
 format-version: 1.2
-data-version: empty/releases/2026-02-23/empty-base.owl
+data-version: empty/releases/2026-04-04/empty-base.owl
 idspace: dce http://purl.org/dc/elements/1.1/ 
 idspace: dcterms http://purl.org/dc/terms/ 
 idspace: oboInOwl http://www.geneontology.org/formats/oboInOwl# 
@@ -9,7 +9,7 @@ property_value: dce:type IAO:8000001
 property_value: dcterms:description "An ontology of experimental measurements in the sciences, the purposes for which experimental measurements were made, and experimental treatments, with a focus on life sciences." xsd:string
 property_value: dcterms:license https://creativecommons.org/licenses/by/4.0/
 property_value: dcterms:title "Experimental Measurements Purposes and Treatments ontologY" xsd:string
-property_value: owl:versionInfo "2026-02-23" xsd:string
+property_value: owl:versionInfo "2026-04-04" xsd:string
 property_value: owl:versionInfo "Release 2025-07-10" xsd:string
 
 [Term]
@@ -44,298 +44,298 @@ is_a: EMPTY:0000002 ! behavioral measurement
 [Term]
 id: EMPTY:0000006
 name: elevated plus maze: open arm (north) - entries
-def: "In the Elevated Plus Maze task, this counts the number of times the animal's body (typically defined by its center point or a significant portion) fully enters the user-defined zone designated as 'Open Arm (North)'. The 'Open Arm (North)' is one of the two open arms, distinguished by its assigned 'north' orientation or designation in the experimental setup. Unit of measure: count" []
+def: "In the Elevated Plus Maze task, this counts the number of times the animal's body (typically defined by its center point or a significant portion) fully enters the user-defined zone designated as 'Open Arm (North)'. The 'Open Arm (North)' is one of the two open arms, distinguished by its assigned 'north' orientation or designation in the experimental setup. Unit: count" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 
 [Term]
 id: EMPTY:0000007
 name: elevated plus maze: open arm (south) - entries
-def: "In the Elevated Plus Maze task, this counts the number of times the animal's body (typically defined by its center point or a significant portion) fully enters the user-defined zone designated as 'Open Arm (South)'. The 'Open Arm (South)' is one of the two open arms, distinguished by its assigned 'south' orientation or designation in the experimental setup. Unit of measure: count" []
+def: "In the Elevated Plus Maze task, this counts the number of times the animal's body (typically defined by its center point or a significant portion) fully enters the user-defined zone designated as 'Open Arm (South)'. The 'Open Arm (South)' is one of the two open arms, distinguished by its assigned 'south' orientation or designation in the experimental setup. Unit: count" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 
 [Term]
 id: EMPTY:0000008
 name: elevated plus maze: open arm total entries
-def: "In the Elevated Plus Maze task, this represents the total number of times the animal's body (typically defined by its center point or a significant portion) fully enters the designated open arm zones (e.g., 'Open Arm (North)' and 'Open Arm (South)'). It is a common measure of exploration and anxiety. Unit of measure: count" []
+def: "In the Elevated Plus Maze task, this represents the total number of times the animal's body (typically defined by its center point or a significant portion) fully enters the designated open arm zones (e.g., 'Open Arm (North)' and 'Open Arm (South)'). It is a common measure of exploration and anxiety. Unit: count" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 
 [Term]
 id: EMPTY:0000009
 name: elevated plus maze: open arm (north) - head entries
-def: "In the Elevated Plus Maze task, this counts the number of times the animal's head (specifically tracked by the software) enters the user-defined 'Open Arm (North)' zone, irrespective of full body entry. This can indicate risk assessment or tentative exploration of the arm designated as 'north'. Unit of measure: count" []
+def: "In the Elevated Plus Maze task, this counts the number of times the animal's head (specifically tracked by the software) enters the user-defined 'Open Arm (North)' zone, irrespective of full body entry. This can indicate risk assessment or tentative exploration of the arm designated as 'north'. Unit: count" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 
 [Term]
 id: EMPTY:0000010
 name: elevated plus maze: open arm (south) - head entries
-def: "In the Elevated Plus Maze task, this counts the number of times the animal's head (specifically tracked by the software) enters the user-defined 'Open Arm (South)' zone, irrespective of full body entry, often reflecting cautious exploration of the open arm designated as 'south'. Unit of measure: count" []
+def: "In the Elevated Plus Maze task, this counts the number of times the animal's head (specifically tracked by the software) enters the user-defined 'Open Arm (South)' zone, irrespective of full body entry, often reflecting cautious exploration of the open arm designated as 'south'. Unit: count" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 
 [Term]
 id: EMPTY:0000011
 name: elevated plus maze: open arm total head entries
-def: "In the Elevated Plus Maze task, this is the total number of times the animal's head (specifically tracked by the software) enters any of the designated open arm zones (e.g., 'Open Arm (North)' and 'Open Arm (South)'), considered an indicator of risk-assessment behavior. Unit of measure: count" []
+def: "In the Elevated Plus Maze task, this is the total number of times the animal's head (specifically tracked by the software) enters any of the designated open arm zones (e.g., 'Open Arm (North)' and 'Open Arm (South)'), considered an indicator of risk-assessment behavior. Unit: count" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 
 [Term]
 id: EMPTY:0000012
 name: elevated plus maze: open arm (north) - time
-def: "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Open Arm (North)' zone. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Open Arm (North)' zone. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000013
 name: elevated plus maze: open arm (south) - time
-def: "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Open Arm (South)' zone. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Open Arm (South)' zone. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000014
 name: elevated plus maze: open arm total time
-def: "In the Elevated Plus Maze task, this is the cumulative total duration the animal's body spends within any of the designated open arm zones (e.g., 'Open Arm (North)' and 'Open Arm (South)'). Less time is generally indicative of higher anxiety. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this is the cumulative total duration the animal's body spends within any of the designated open arm zones (e.g., 'Open Arm (North)' and 'Open Arm (South)'). Less time is generally indicative of higher anxiety. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000015
 name: elevated plus maze: open arm total - percent time during test duration
-def: "In the Elevated Plus Maze task, this represents the percentage of the total test duration that the animal spends in any of the designated open arm zones (e.g., 'Open Arm (North)' and 'Open Arm (South)'). Unit of measure: %" []
+def: "In the Elevated Plus Maze task, this represents the percentage of the total test duration that the animal spends in any of the designated open arm zones (e.g., 'Open Arm (North)' and 'Open Arm (South)'). Unit: %" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 
 [Term]
 id: EMPTY:0000016
 name: elevated plus maze: open arm (north) - latency to first entry
-def: "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Open Arm (North)' zone. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Open Arm (North)' zone. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000091 ! timepoint
 
 [Term]
 id: EMPTY:0000017
 name: elevated plus maze: open arm (south) - latency to first entry
-def: "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Open Arm (South)' zone. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Open Arm (South)' zone. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000091 ! timepoint
 
 [Term]
 id: EMPTY:0000018
 name: elevated plus maze: open arm total latency to first entry
-def: "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into any of the designated open arm zones (e.g., 'Open Arm (North)' or 'Open Arm (South)'). Longer latencies often suggest higher anxiety. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into any of the designated open arm zones (e.g., 'Open Arm (North)' or 'Open Arm (South)'). Longer latencies often suggest higher anxiety. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000091 ! timepoint
 
 [Term]
 id: EMPTY:0000019
 name: elevated plus maze: open arm (north) - time moving towards
-def: "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Open Arm (North)' zone, as detected by the tracking software. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Open Arm (North)' zone, as detected by the tracking software. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000020
 name: elevated plus maze: open arm (south) - time moving towards
-def: "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Open Arm (South)' zone, as detected by the tracking software. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Open Arm (South)' zone, as detected by the tracking software. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000021
 name: elevated plus maze: open arm total time moving towards
-def: "In the Elevated Plus Maze task, this is the cumulative duration the animal spends actively moving towards any of the designated open arm zones (e.g., 'Open Arm (North)' or 'Open Arm (South)'), reflecting approach motivation. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this is the cumulative duration the animal spends actively moving towards any of the designated open arm zones (e.g., 'Open Arm (North)' or 'Open Arm (South)'), reflecting approach motivation. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000022
 name: elevated plus maze: open arm (north) - time freezing
-def: "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior (a state of immobility except for respiratory movements) while within the user-defined 'Open Arm (North)' zone. Freezing is a common fear response. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior (a state of immobility except for respiratory movements) while within the user-defined 'Open Arm (North)' zone. Freezing is a common fear response. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000023
 name: elevated plus maze: open arm (south) - time freezing
-def: "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined 'Open Arm (South)' zone. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined 'Open Arm (South)' zone. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000024
 name: elevated plus maze: open arm total time freezing
-def: "In the Elevated Plus Maze task, this is the cumulative duration the animal exhibits freezing behavior while within any of the designated open arm zones (e.g., 'Open Arm (North)' or 'Open Arm (South)'), indicating fear or anxiety. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this is the cumulative duration the animal exhibits freezing behavior while within any of the designated open arm zones (e.g., 'Open Arm (North)' or 'Open Arm (South)'), indicating fear or anxiety. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000025
 name: elevated plus maze: closed arm (west) - entries
-def: "In the Elevated Plus Maze task, this counts the number of times the animal's body fully enters the user-defined 'Closed Arm (West)' zone, representing the enclosed arm designated as 'west'. Unit of measure: count" []
+def: "In the Elevated Plus Maze task, this counts the number of times the animal's body fully enters the user-defined 'Closed Arm (West)' zone, representing the enclosed arm designated as 'west'. Unit: count" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 
 [Term]
 id: EMPTY:0000026
 name: elevated plus maze: closed arm (east) - entries
-def: "In the Elevated Plus Maze task, this counts the number of times the animal's body fully enters the user-defined 'Closed Arm (East)' zone, representing the enclosed arm designated as 'east'. Unit of measure: count" []
+def: "In the Elevated Plus Maze task, this counts the number of times the animal's body fully enters the user-defined 'Closed Arm (East)' zone, representing the enclosed arm designated as 'east'. Unit: count" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 
 [Term]
 id: EMPTY:0000027
 name: elevated plus maze: closed arm total entries
-def: "In the Elevated Plus Maze task, this is the total number of times the animal's body fully enters any of the designated closed arm zones (e.g., 'Closed Arm (West)' and 'Closed Arm (East)'). It is often used as an indicator of general locomotor activity. Unit of measure: count" []
+def: "In the Elevated Plus Maze task, this is the total number of times the animal's body fully enters any of the designated closed arm zones (e.g., 'Closed Arm (West)' and 'Closed Arm (East)'). It is often used as an indicator of general locomotor activity. Unit: count" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 
 [Term]
 id: EMPTY:0000028
 name: elevated plus maze: closed arm (west) - head entries
-def: "In the Elevated Plus Maze task, this counts the number of times the animal's head enters the user-defined 'Closed Arm (West)' zone. Unit of measure: count" []
+def: "In the Elevated Plus Maze task, this counts the number of times the animal's head enters the user-defined 'Closed Arm (West)' zone. Unit: count" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 
 [Term]
 id: EMPTY:0000029
 name: elevated plus maze: closed arm (east) - head entries
-def: "In the Elevated Plus Maze task, this counts the number of times the animal's head enters the user-defined 'Closed Arm (East)' zone. Unit of measure: count" []
+def: "In the Elevated Plus Maze task, this counts the number of times the animal's head enters the user-defined 'Closed Arm (East)' zone. Unit: count" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 
 [Term]
 id: EMPTY:0000030
 name: elevated plus maze: closed arm total head entries
-def: "In the Elevated Plus Maze task, this is the total number of times the animal's head enters any of the designated closed arm zones (e.g., 'Closed Arm (West)' and 'Closed Arm (East)'). Unit of measure: count" []
+def: "In the Elevated Plus Maze task, this is the total number of times the animal's head enters any of the designated closed arm zones (e.g., 'Closed Arm (West)' and 'Closed Arm (East)'). Unit: count" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 
 [Term]
 id: EMPTY:0000031
 name: elevated plus maze: closed arm (west) - time
-def: "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Closed Arm (West)' zone. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Closed Arm (West)' zone. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000032
 name: elevated plus maze: closed arm (east) - time
-def: "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Closed Arm (East)' zone. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Closed Arm (East)' zone. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000033
 name: elevated plus maze: closed arm total time
-def: "In the Elevated Plus Maze task, this is the cumulative total duration the animal's body spends within any of the designated closed arm zones (e.g., 'Closed Arm (West)' and 'Closed Arm (East)'). Animals typically spend more time in these 'safer' areas. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this is the cumulative total duration the animal's body spends within any of the designated closed arm zones (e.g., 'Closed Arm (West)' and 'Closed Arm (East)'). Animals typically spend more time in these 'safer' areas. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000034
 name: elevated plus maze: closed arm total - percent time during test duration
-def: "In the Elevated Plus Maze task, this represents the percentage of the total test duration that the animal spends in any of the designated closed arm zones (e.g., 'Closed Arm (West)' and 'Closed Arm (East)'). Unit of measure: %" []
+def: "In the Elevated Plus Maze task, this represents the percentage of the total test duration that the animal spends in any of the designated closed arm zones (e.g., 'Closed Arm (West)' and 'Closed Arm (East)'). Unit: %" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 
 [Term]
 id: EMPTY:0000035
 name: elevated plus maze: closed arm (west) - latency to first entry
-def: "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Closed Arm (West)' zone. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Closed Arm (West)' zone. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000091 ! timepoint
 
 [Term]
 id: EMPTY:0000036
 name: elevated plus maze: closed arm (east) - latency to first entry
-def: "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Closed Arm (East)' zone. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Closed Arm (East)' zone. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000091 ! timepoint
 
 [Term]
 id: EMPTY:0000037
 name: elevated plus maze: closed arm total latency to first entry
-def: "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into any of the designated closed arm zones (e.g., 'Closed Arm (West)' or 'Closed Arm (East)'). Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into any of the designated closed arm zones (e.g., 'Closed Arm (West)' or 'Closed Arm (East)'). Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000091 ! timepoint
 
 [Term]
 id: EMPTY:0000038
 name: elevated plus maze: closed arm (west) - time moving towards
-def: "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Closed Arm (West)' zone. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Closed Arm (West)' zone. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000039
 name: elevated plus maze: closed arm (east) - time moving towards
-def: "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Closed Arm (East)' zone. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Closed Arm (East)' zone. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000040
 name: elevated plus maze: closed arm total time moving towards
-def: "In the Elevated Plus Maze task, this is the cumulative duration the animal spends actively moving towards any of the designated closed arm zones (e.g., 'Closed Arm (West)' or 'Closed Arm (East)'). Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this is the cumulative duration the animal spends actively moving towards any of the designated closed arm zones (e.g., 'Closed Arm (West)' or 'Closed Arm (East)'). Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000041
 name: elevated plus maze: closed arm (west) - time freezing
-def: "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined 'Closed Arm (West)' zone. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined 'Closed Arm (West)' zone. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000042
 name: elevated plus maze: closed arm (east) - time freezing
-def: "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined 'Closed Arm (East)' zone. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined 'Closed Arm (East)' zone. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000043
 name: elevated plus maze: closed arm total time freezing
-def: "In the Elevated Plus Maze task, this is the cumulative duration the animal exhibits freezing behavior while within any of the designated closed arm zones (e.g., 'Closed Arm (West)' or 'Closed Arm (East)'). Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this is the cumulative duration the animal exhibits freezing behavior while within any of the designated closed arm zones (e.g., 'Closed Arm (West)' or 'Closed Arm (East)'). Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000044
 name: elevated plus maze: center - entries
-def: "In the Elevated Plus Maze task, this counts the number of times the animal's body fully enters the user-defined 'Center' zone of the maze, typically from one of the arms. The center zone is the area where all four arms meet. Unit of measure: count" []
+def: "In the Elevated Plus Maze task, this counts the number of times the animal's body fully enters the user-defined 'Center' zone of the maze, typically from one of the arms. The center zone is the area where all four arms meet. Unit: count" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 
 [Term]
 id: EMPTY:0000045
 name: elevated plus maze: center - head entries
-def: "In the Elevated Plus Maze task, this counts the number of times the animal's head enters the user-defined 'Center' zone of the maze. Unit of measure: count" []
+def: "In the Elevated Plus Maze task, this counts the number of times the animal's head enters the user-defined 'Center' zone of the maze. Unit: count" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 
 [Term]
 id: EMPTY:0000046
 name: elevated plus maze: center - time
-def: "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Center' zone. Time in the center can indicate decision-making or risk assessment. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Center' zone. Time in the center can indicate decision-making or risk assessment. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000047
 name: elevated plus maze: center - percent time during test duration
-def: "In the Elevated Plus Maze task, this represents the percentage of the total test duration that the animal spends in the user-defined 'Center' zone of the maze. Unit of measure: %" []
+def: "In the Elevated Plus Maze task, this represents the percentage of the total test duration that the animal spends in the user-defined 'Center' zone of the maze. Unit: %" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 
 [Term]
 id: EMPTY:0000048
 name: elevated plus maze: center - latency to first entry
-def: "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Center' zone. If the animal starts in the center, this value may be zero or not applicable. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Center' zone. If the animal starts in the center, this value may be zero or not applicable. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000091 ! timepoint
 
 [Term]
 id: EMPTY:0000049
 name: elevated plus maze: center - time moving towards
-def: "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Center' zone of the maze (e.g., from an arm). Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Center' zone of the maze (e.g., from an arm). Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000050
 name: elevated plus maze: center - time freezing
-def: "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined 'Center' zone of the maze. Freezing in this relatively exposed area can indicate high anxiety. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined 'Center' zone of the maze. Freezing in this relatively exposed area can indicate high anxiety. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
@@ -354,7 +354,7 @@ is_a: EMPTY:0000084 ! categorical identifier
 [Term]
 id: EMPTY:0000053
 name: fear-potentiated startle: baseline acoustic startle response amplitude
-def: "In the Fear-potentiated startle paradigm, this is the amplitude of the acoustic startle response (ASR) measured in response to a startle-eliciting stimulus (e.g., 95-dB white noise burst) prior to any fear conditioning procedures, typically assessed during habituation or pre-conditioning phase. This measurement serves as a reference point for later comparisons with post-conditioning startle responses. Unit of measure: arbitrary units or standardized score." []
+def: "In the Fear-potentiated startle paradigm, this is the amplitude of the acoustic startle response (ASR) measured in response to a startle-eliciting stimulus (e.g., 95-dB white noise burst) prior to any fear conditioning procedures, typically assessed during habituation or pre-conditioning phase. This measurement serves as a reference point for later comparisons with post-conditioning startle responses. Unit: arbitrary units or standardized score." []
 is_a: EMPTY:0000004 ! acoustic startle response measurement
 is_a: EMPTY:0000162 ! amplitude
 
@@ -386,7 +386,7 @@ is_a: EMPTY:0000093 ! fear-potentiated startle parameter
 [Term]
 id: EMPTY:0000058
 name: fear-potentiated startle: apparatus chamber identifier
-def: "Identifier for the specific Plexiglas enclosure or sound-attenuating chamber within the Fear-Potentiated Startle (FPS) apparatus (e.g., San Diego Instruments SR-Lab) in which a subject was tested for a given trial. Unit of measure: count or identifier string" []
+def: "Identifier for the specific Plexiglas enclosure or sound-attenuating chamber within the Fear-Potentiated Startle (FPS) apparatus (e.g., San Diego Instruments SR-Lab) in which a subject was tested for a given trial. Unit: count or identifier string" []
 is_a: EMPTY:0000093 ! fear-potentiated startle parameter
 
 [Term]
@@ -398,40 +398,40 @@ is_a: EMPTY:0000084 ! categorical identifier
 [Term]
 id: EMPTY:0000060
 name: acoustic startle response: number of samples
-def: "The total number of data points (samples) recorded and analyzed for a single acoustic startle response, typically within a defined time window following stimulus onset (e.g., a 200-ms window as mentioned in the manuscript). Unit of measure: count" []
+def: "The total number of data points (samples) recorded and analyzed for a single acoustic startle response, typically within a defined time window following stimulus onset (e.g., a 200-ms window as mentioned in the manuscript). Unit: count" []
 is_a: EMPTY:0000093 ! fear-potentiated startle parameter
 
 [Term]
 id: EMPTY:0000061
 name: acoustic startle response: sampling rate
-def: "The rate at which the analog startle response signal was digitized during data acquisition. Unit of measure: Hertz (Hz)" []
+def: "The rate at which the analog startle response signal was digitized during data acquisition. Unit: Hertz (Hz)" []
 is_a: EMPTY:0000093 ! fear-potentiated startle parameter
 
 [Term]
 id: EMPTY:0000062
 name: acoustic startle response: startle window onset amplitude
-def: "The amplitude of the digitized acoustic startle response signal at the very beginning (onset) of the defined analysis window (e.g., a 200-ms window) used to quantify the reflex. Unit of measure: millivolts (mV) or arbitrary units based on transducer calibration." []
+def: "The amplitude of the digitized acoustic startle response signal at the very beginning (onset) of the defined analysis window (e.g., a 200-ms window) used to quantify the reflex. Unit: millivolts (mV) or arbitrary units based on transducer calibration." []
 is_a: EMPTY:0000004 ! acoustic startle response measurement
 is_a: EMPTY:0000162 ! amplitude
 
 [Term]
 id: EMPTY:0000063
 name: acoustic startle response: maximum amplitude
-def: "The peak amplitude of the acoustic startle response (e.g., 'jump amplitude') detected within the defined analysis window (e.g., 200-ms window) for a given trial. Unit of measure: millivolts (mV) or arbitrary units." []
+def: "The peak amplitude of the acoustic startle response (e.g., 'jump amplitude') detected within the defined analysis window (e.g., 200-ms window) for a given trial. Unit: millivolts (mV) or arbitrary units." []
 is_a: EMPTY:0000004 ! acoustic startle response measurement
 is_a: EMPTY:0000162 ! amplitude
 
 [Term]
 id: EMPTY:0000064
 name: acoustic startle response: time to maximum amplitude
-def: "The latency from the onset of the startle-eliciting stimulus (or the beginning of the analysis window) to the occurrence of the maximum (peak) amplitude of the acoustic startle response. Unit of measure: milliseconds (ms)" []
+def: "The latency from the onset of the startle-eliciting stimulus (or the beginning of the analysis window) to the occurrence of the maximum (peak) amplitude of the acoustic startle response. Unit: milliseconds (ms)" []
 is_a: EMPTY:0000004 ! acoustic startle response measurement
 is_a: EMPTY:0000091 ! timepoint
 
 [Term]
 id: EMPTY:0000065
 name: acoustic startle response: average amplitude
-def: "The average amplitude of the digitized acoustic startle response signal calculated across the entire duration of the defined analysis window (e.g., 200-ms window). Unit of measure: millivolts (mV) or arbitrary units." []
+def: "The average amplitude of the digitized acoustic startle response signal calculated across the entire duration of the defined analysis window (e.g., 200-ms window). Unit: millivolts (mV) or arbitrary units." []
 is_a: EMPTY:0000004 ! acoustic startle response measurement
 is_a: EMPTY:0000162 ! amplitude
 
@@ -451,7 +451,7 @@ is_a: EMPTY:0000093 ! fear-potentiated startle parameter
 [Term]
 id: EMPTY:0000068
 name: elevated plus maze: test duration
-def: "In the Elevated Plus Maze task, this is the time of the total test duration in seconds'). Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this is the time of the total test duration in seconds'). Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 is_a: EMPTY:0000092 ! elevated plus maze parameter
@@ -1155,13 +1155,13 @@ is_a: EMPTY:0000164 ! contextual fear conditioning parameter
 [Term]
 id: EMPTY:0000175
 name: contextual fear conditioning: time freezing
-def: "The number of seconds the individual spent freezing during a given period of time. Unit of measure: seconds" []
+def: "The number of seconds the individual spent freezing during a given period of time. Unit: seconds" []
 is_a: EMPTY:0000163 ! contextual fear conditioning measurement
 
 [Term]
 id: EMPTY:0000176
 name: contextual fear conditioning: block duration
-def: "In the contextual fear conditioning paradigm, this is the time of the block duration in seconds. Unit of measure: seconds" []
+def: "In the contextual fear conditioning paradigm, this is the time of the block duration in seconds. Unit: seconds" []
 is_a: EMPTY:0000163 ! contextual fear conditioning measurement
 is_a: EMPTY:0000164 ! contextual fear conditioning parameter
 
@@ -1501,3 +1501,172 @@ name: unknown electronic file type
 def: "A digital file for which the format, encoding, or origin cannot be definitively identified by the system or investigator, necessitating further manual review or specialized software for interpretation." []
 is_a: NCIT:C172272
 
+[Term]
+id: EMPTY:0000231
+name: C. elegans chemotaxis assay parameter
+def: "A parameter that specifies the technical settings, environmental conditions, or experimental design of a chemotaxis assay involving Caenorhabditis elegans." []
+is_a: EMPTY:0000101 ! C. elegans behavioral assay parameter
+
+[Term]
+id: EMPTY:0000232
+name: C. elegans chemotaxis assay parameter: chemoattractant mixture table
+def: "A table containing the quantities and identities of all chemicals used as a chemoattractant (e.g., isoamyl alcohol, diacetyl) to elicit a directed movement response in C. elegans." []
+is_a: EMPTY:0000231 ! C. elegans chemotaxis assay parameter
+
+[Term]
+id: EMPTY:0000233
+name: C. elegans chemotaxis assay parameter: chemoattractant mixture volume
+def: "The volume of the chemoattractant mixture pipetted onto the agar plate in a chemotaxis assay. Unit: microliters (μL)." []
+is_a: EMPTY:0000231 ! C. elegans chemotaxis assay parameter
+
+[Term]
+id: EMPTY:0000234
+name: C. elegans chemotaxis assay parameter: assay duration
+def: "The total time elapsed from the point at which C. elegans are placed on the assay plate until the movement is arrested or the final positions are recorded. Unit: minutes." []
+is_a: EMPTY:0000231 ! C. elegans chemotaxis assay parameter
+
+[Term]
+id: EMPTY:0000235
+name: C. elegans chemotaxis assay measurement
+def: "A quantitative or qualitative value derived from a C. elegans chemotaxis assay, typically describing the efficiency or directionality of the animals' movement toward or away from a chemical source." []
+is_a: EMPTY:0000100 ! C. elegans behavioral assay measurement
+
+[Term]
+id: EMPTY:0000236
+name: C. elegans chemotaxis assay measurement: McCutcheon index
+def: "A behavioral measurement of chemotactic efficiency defined as the ratio of the straight-line displacement toward the attractant to the total path length traveled by the organism. Values range from -1 to 1." []
+synonym: "chemotactic ratio" EXACT []
+is_a: EMPTY:0000235 ! C. elegans chemotaxis assay measurement
+
+[Term]
+id: EMPTY:0000237
+name: C. elegans chemotaxis assay measurement: mean velocity
+def: "The average speed of a C. elegans individual or population during the duration of the chemotaxis assay. Unit: micrometers per second (µm/s)." []
+is_a: EMPTY:0000235 ! C. elegans chemotaxis assay measurement
+
+[Term]
+id: EMPTY:0000238
+name: investigator-defined strain
+def: "A specific genetic variant or line of an organism designated by the investigator, often containing unique mutations, transgenes, or genomic edits not yet categorized in a public repository." []
+is_a: EMPTY:0000076 ! descriptor
+
+[Term]
+id: EMPTY:0000239
+name: C. elegans strain
+def: "A specific strain of Caenorhabditis elegans, identified by its genotype or a standard nomenclature (e.g., N2, CB4856), used in experimental procedures." []
+is_a: EMPTY:0000238 ! investigator-defined strain
+
+[Term]
+id: EMPTY:0000240
+name: BAB9001
+def: "A C. elegans strain with the genotype daf-22 (m130). This strain was originally obtained from the Caenorhabditis Genetics Center (CGC) as strain DR476 and subsequently outcrossed three times. [Source: https://doi.org/TBD]" []
+is_a: EMPTY:0000239 ! C. elegans strain
+
+[Term]
+id: EMPTY:0000241
+name: BAB9002
+def: "A C. elegans klp-6 rescue strain with the genotype klp-6 (my8); Pklp-6::GFP::KLP-6 (array, IndEx 9002). [Source: https://doi.org/TBD]" []
+is_a: EMPTY:0000239 ! C. elegans strain
+
+[Term]
+id: EMPTY:0000242
+name: TM5848
+def: "A C. elegans strain with the genotype cil-7 (tm5848) I, exhibiting a him phenotype. This strain was obtained from the National BioResource Project (NBRP), Japan. [Source: https://doi.org/TBD]" []
+is_a: EMPTY:0000239 ! C. elegans strain
+
+[Term]
+id: EMPTY:0000243
+name: PT3602
+def: "A C. elegans strain with the genotype cil-7 (my61[cil-7::mNG])I; him-5(e1490) V. This strain was provided as a gift from the Maureen Barr lab. [Source: https://doi.org/TBD]" []
+is_a: EMPTY:0000239 ! C. elegans strain
+
+[Term]
+id: EMPTY:0000244
+name: BAB9003
+def: "A C. elegans strain with the genotype PT3602; Pnlp-43_hCaspase nZ (array IndEx 9003). [Source: https://doi.org/TBD]" []
+is_a: EMPTY:0000239 ! C. elegans strain
+
+[Term]
+id: EMPTY:0000245
+name: BAB9004
+def: "A C. elegans strain with the genotype PT3602; Pklp-6_hCaspase Cz (array IndEx 9004). [Source: https://doi.org/TBD]" []
+is_a: EMPTY:0000239 ! C. elegans strain
+
+[Term]
+id: EMPTY:0000246
+name: BAB9005
+def: "A C. elegans strain with the genotype PT3602; Pnlp-43_hCaspase nZ (array IndEx 9003) and Pklp-6_hCaspase Cz (array IndEx 9004). [Source: https://doi.org/TBD]" []
+is_a: EMPTY:0000239 ! C. elegans strain
+
+[Term]
+id: EMPTY:0000247
+name: fluorescence imaging measurement
+def: "fluorescence imaging measurement" []
+is_a: EMPTY:0000001 ! measurement
+
+[Term]
+id: EMPTY:0000248
+name: mean fluorescence intensity
+def: "Mean fluorescence intensity. Unit: arbitrary units (AU)" []
+is_a: EMPTY:0000247 ! fluorescence imaging measurement
+
+[Term]
+id: EMPTY:0000249
+name: fluorescent punctal count
+def: "A quantitative measurement of the number of distinct fluorescent spots or puncta detected within a defined region of interest in a fluorescence image. Unit: count" []
+is_a: EMPTY:0000247 ! fluorescence imaging measurement
+
+[Term]
+id: EMPTY:0000250
+name: fluorescence imaging parameter
+def: "A specific parameter related to fluorescence imaging acquisition or assay." []
+is_a: EMPTY:0000080 ! parameter
+
+[Term]
+id: EMPTY:0000251
+name: fluorescence target ontology identifier
+def: "fluorescence target ontology identifier" []
+is_a: EMPTY:0000250 ! fluorescence imaging parameter
+
+[Term]
+id: EMPTY:0000252
+name: fluorescence target name
+def: "fluorescence target name" []
+is_a: EMPTY:0000250 ! fluorescence imaging parameter
+
+[Term]
+id: EMPTY:0000253
+name: SnapGene file format
+def: "A .dna file format designed for storing annotated DNA sequences, including linear/circular topology, features, primers, and enzyme sites." []
+is_a: format:1929
+
+[Term]
+id: EMPTY:0000254
+name: Escherichia coli OP50: heat-killed
+def: "A preparation of Escherichia coli strain OP50 that has been rendered non-viable through the application of heat, typically used as a non-proliferating food source in C. elegans assays." []
+is_a: NCBITaxon:637912
+
+[Term]
+id: EMPTY:0000255
+name: C. elegans transfer method: M9 buffer wash
+def: "Method used to transfer C. elegans whereby an M9 buffer is used to wash C. elegans off of an agar plate. Animals can then be transferred using a piper." []
+is_a: EMPTY:0000189 ! treatment
+
+[Term]
+id: EMPTY:0000256
+name: C. elegans transfer method: titanium pick
+def: "Method used to transfer C. elegans whereby a titanium pick is used to scoop animals off of an agar plate." []
+is_a: EMPTY:0000189 ! treatment
+
+[Term]
+id: EMPTY:0000257
+name: C. elegans chemotaxis assay: video recording
+def: "A video recording capturing the behavior of C. elegans during a chemotaxis assay." []
+is_a: EMPTY:0000129 ! C. elegans behavioral assay: video recording
+
+[Term]
+id: EMPTY:0000258
+name: fluorescence imaging data
+def: "An image or video acquired using fluorescence microscopy." []
+is_a: NCIT:C16856
+
diff --git a/empty-base.owl b/empty-base.owl
index 40ef4ba..f7d072d 100644
--- a/empty-base.owl
+++ b/empty-base.owl
@@ -11,14 +11,14 @@
      xmlns:dcterms="http://purl.org/dc/terms/"
      xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#">
     <owl:Ontology rdf:about="http://purl.obolibrary.org/obo/empty/empty-base.owl">
-        <owl:versionIRI rdf:resource="http://purl.obolibrary.org/obo/empty/releases/2026-02-23/empty-base.owl"/>
+        <owl:versionIRI rdf:resource="http://purl.obolibrary.org/obo/empty/releases/2026-04-04/empty-base.owl"/>
         <dce:type rdf:resource="http://purl.obolibrary.org/obo/IAO_8000001"/>
         <dcterms:description>An ontology of experimental measurements in the sciences, the purposes for which experimental measurements were made, and experimental treatments, with a focus on life sciences.</dcterms:description>
         <dcterms:license rdf:resource="https://creativecommons.org/licenses/by/4.0/"/>
         <dcterms:title>Experimental Measurements Purposes and Treatments ontologY</dcterms:title>
         <rdfs:comment>EMPTY by NDI is licensed under CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/). You are free to share (copy and redistribute the material in any medium or format) and adapt (remix, transform, and build upon the material) for any purpose, even commercially. You must give appropriate credit (by using the original ontology IRI for the whole ontology or original term IRIs for individual terms), provide a link to the license, and indicate if any changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.</rdfs:comment>
         <owl:versionInfo>Release 2025-07-10</owl:versionInfo>
-        <owl:versionInfo>2026-02-23</owl:versionInfo>
+        <owl:versionInfo>2026-04-04</owl:versionInfo>
     </owl:Ontology>
     
 
@@ -140,7 +140,7 @@
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000006">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s body (typically defined by its center point or a significant portion) fully enters the user-defined zone designated as &apos;Open Arm (North)&apos;. The &apos;Open Arm (North)&apos; is one of the two open arms, distinguished by its assigned &apos;north&apos; orientation or designation in the experimental setup. Unit of measure: count</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s body (typically defined by its center point or a significant portion) fully enters the user-defined zone designated as &apos;Open Arm (North)&apos;. The &apos;Open Arm (North)&apos; is one of the two open arms, distinguished by its assigned &apos;north&apos; orientation or designation in the experimental setup. Unit: count</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: open arm (north) - entries</rdfs:label>
     </owl:Class>
     
@@ -150,7 +150,7 @@
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000007">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s body (typically defined by its center point or a significant portion) fully enters the user-defined zone designated as &apos;Open Arm (South)&apos;. The &apos;Open Arm (South)&apos; is one of the two open arms, distinguished by its assigned &apos;south&apos; orientation or designation in the experimental setup. Unit of measure: count</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s body (typically defined by its center point or a significant portion) fully enters the user-defined zone designated as &apos;Open Arm (South)&apos;. The &apos;Open Arm (South)&apos; is one of the two open arms, distinguished by its assigned &apos;south&apos; orientation or designation in the experimental setup. Unit: count</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: open arm (south) - entries</rdfs:label>
     </owl:Class>
     
@@ -160,7 +160,7 @@
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000008">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this represents the total number of times the animal&apos;s body (typically defined by its center point or a significant portion) fully enters the designated open arm zones (e.g., &apos;Open Arm (North)&apos; and &apos;Open Arm (South)&apos;). It is a common measure of exploration and anxiety. Unit of measure: count</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this represents the total number of times the animal&apos;s body (typically defined by its center point or a significant portion) fully enters the designated open arm zones (e.g., &apos;Open Arm (North)&apos; and &apos;Open Arm (South)&apos;). It is a common measure of exploration and anxiety. Unit: count</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: open arm total entries</rdfs:label>
     </owl:Class>
     
@@ -170,7 +170,7 @@
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000009">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s head (specifically tracked by the software) enters the user-defined &apos;Open Arm (North)&apos; zone, irrespective of full body entry. This can indicate risk assessment or tentative exploration of the arm designated as &apos;north&apos;. Unit of measure: count</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s head (specifically tracked by the software) enters the user-defined &apos;Open Arm (North)&apos; zone, irrespective of full body entry. This can indicate risk assessment or tentative exploration of the arm designated as &apos;north&apos;. Unit: count</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: open arm (north) - head entries</rdfs:label>
     </owl:Class>
     
@@ -180,7 +180,7 @@
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000010">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s head (specifically tracked by the software) enters the user-defined &apos;Open Arm (South)&apos; zone, irrespective of full body entry, often reflecting cautious exploration of the open arm designated as &apos;south&apos;. Unit of measure: count</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s head (specifically tracked by the software) enters the user-defined &apos;Open Arm (South)&apos; zone, irrespective of full body entry, often reflecting cautious exploration of the open arm designated as &apos;south&apos;. Unit: count</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: open arm (south) - head entries</rdfs:label>
     </owl:Class>
     
@@ -190,7 +190,7 @@
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000011">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the total number of times the animal&apos;s head (specifically tracked by the software) enters any of the designated open arm zones (e.g., &apos;Open Arm (North)&apos; and &apos;Open Arm (South)&apos;), considered an indicator of risk-assessment behavior. Unit of measure: count</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the total number of times the animal&apos;s head (specifically tracked by the software) enters any of the designated open arm zones (e.g., &apos;Open Arm (North)&apos; and &apos;Open Arm (South)&apos;), considered an indicator of risk-assessment behavior. Unit: count</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: open arm total head entries</rdfs:label>
     </owl:Class>
     
@@ -201,7 +201,7 @@
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000012">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal&apos;s body spends within the user-defined &apos;Open Arm (North)&apos; zone. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal&apos;s body spends within the user-defined &apos;Open Arm (North)&apos; zone. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: open arm (north) - time</rdfs:label>
     </owl:Class>
     
@@ -212,7 +212,7 @@
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000013">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal&apos;s body spends within the user-defined &apos;Open Arm (South)&apos; zone. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal&apos;s body spends within the user-defined &apos;Open Arm (South)&apos; zone. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: open arm (south) - time</rdfs:label>
     </owl:Class>
     
@@ -223,7 +223,7 @@
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000014">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the cumulative total duration the animal&apos;s body spends within any of the designated open arm zones (e.g., &apos;Open Arm (North)&apos; and &apos;Open Arm (South)&apos;). Less time is generally indicative of higher anxiety. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the cumulative total duration the animal&apos;s body spends within any of the designated open arm zones (e.g., &apos;Open Arm (North)&apos; and &apos;Open Arm (South)&apos;). Less time is generally indicative of higher anxiety. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: open arm total time</rdfs:label>
     </owl:Class>
     
@@ -233,7 +233,7 @@
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000015">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this represents the percentage of the total test duration that the animal spends in any of the designated open arm zones (e.g., &apos;Open Arm (North)&apos; and &apos;Open Arm (South)&apos;). Unit of measure: %</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this represents the percentage of the total test duration that the animal spends in any of the designated open arm zones (e.g., &apos;Open Arm (North)&apos; and &apos;Open Arm (South)&apos;). Unit: %</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: open arm total - percent time during test duration</rdfs:label>
     </owl:Class>
     
@@ -244,7 +244,7 @@
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000016">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000091"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined &apos;Open Arm (North)&apos; zone. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined &apos;Open Arm (North)&apos; zone. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: open arm (north) - latency to first entry</rdfs:label>
     </owl:Class>
     
@@ -255,7 +255,7 @@
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000017">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000091"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined &apos;Open Arm (South)&apos; zone. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined &apos;Open Arm (South)&apos; zone. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: open arm (south) - latency to first entry</rdfs:label>
     </owl:Class>
     
@@ -266,7 +266,7 @@
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000018">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000091"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into any of the designated open arm zones (e.g., &apos;Open Arm (North)&apos; or &apos;Open Arm (South)&apos;). Longer latencies often suggest higher anxiety. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into any of the designated open arm zones (e.g., &apos;Open Arm (North)&apos; or &apos;Open Arm (South)&apos;). Longer latencies often suggest higher anxiety. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: open arm total latency to first entry</rdfs:label>
     </owl:Class>
     
@@ -277,7 +277,7 @@
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000019">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined &apos;Open Arm (North)&apos; zone, as detected by the tracking software. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined &apos;Open Arm (North)&apos; zone, as detected by the tracking software. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: open arm (north) - time moving towards</rdfs:label>
     </owl:Class>
     
@@ -288,7 +288,7 @@
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000020">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined &apos;Open Arm (South)&apos; zone, as detected by the tracking software. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined &apos;Open Arm (South)&apos; zone, as detected by the tracking software. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: open arm (south) - time moving towards</rdfs:label>
     </owl:Class>
     
@@ -299,7 +299,7 @@
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000021">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the cumulative duration the animal spends actively moving towards any of the designated open arm zones (e.g., &apos;Open Arm (North)&apos; or &apos;Open Arm (South)&apos;), reflecting approach motivation. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the cumulative duration the animal spends actively moving towards any of the designated open arm zones (e.g., &apos;Open Arm (North)&apos; or &apos;Open Arm (South)&apos;), reflecting approach motivation. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: open arm total time moving towards</rdfs:label>
     </owl:Class>
     
@@ -310,7 +310,7 @@
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000022">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior (a state of immobility except for respiratory movements) while within the user-defined &apos;Open Arm (North)&apos; zone. Freezing is a common fear response. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior (a state of immobility except for respiratory movements) while within the user-defined &apos;Open Arm (North)&apos; zone. Freezing is a common fear response. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: open arm (north) - time freezing</rdfs:label>
     </owl:Class>
     
@@ -321,7 +321,7 @@
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000023">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined &apos;Open Arm (South)&apos; zone. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined &apos;Open Arm (South)&apos; zone. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: open arm (south) - time freezing</rdfs:label>
     </owl:Class>
     
@@ -332,7 +332,7 @@
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000024">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the cumulative duration the animal exhibits freezing behavior while within any of the designated open arm zones (e.g., &apos;Open Arm (North)&apos; or &apos;Open Arm (South)&apos;), indicating fear or anxiety. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the cumulative duration the animal exhibits freezing behavior while within any of the designated open arm zones (e.g., &apos;Open Arm (North)&apos; or &apos;Open Arm (South)&apos;), indicating fear or anxiety. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: open arm total time freezing</rdfs:label>
     </owl:Class>
     
@@ -342,7 +342,7 @@
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000025">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s body fully enters the user-defined &apos;Closed Arm (West)&apos; zone, representing the enclosed arm designated as &apos;west&apos;. Unit of measure: count</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s body fully enters the user-defined &apos;Closed Arm (West)&apos; zone, representing the enclosed arm designated as &apos;west&apos;. Unit: count</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: closed arm (west) - entries</rdfs:label>
     </owl:Class>
     
@@ -352,7 +352,7 @@
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000026">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s body fully enters the user-defined &apos;Closed Arm (East)&apos; zone, representing the enclosed arm designated as &apos;east&apos;. Unit of measure: count</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s body fully enters the user-defined &apos;Closed Arm (East)&apos; zone, representing the enclosed arm designated as &apos;east&apos;. Unit: count</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: closed arm (east) - entries</rdfs:label>
     </owl:Class>
     
@@ -362,7 +362,7 @@
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000027">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the total number of times the animal&apos;s body fully enters any of the designated closed arm zones (e.g., &apos;Closed Arm (West)&apos; and &apos;Closed Arm (East)&apos;). It is often used as an indicator of general locomotor activity. Unit of measure: count</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the total number of times the animal&apos;s body fully enters any of the designated closed arm zones (e.g., &apos;Closed Arm (West)&apos; and &apos;Closed Arm (East)&apos;). It is often used as an indicator of general locomotor activity. Unit: count</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: closed arm total entries</rdfs:label>
     </owl:Class>
     
@@ -372,7 +372,7 @@
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000028">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s head enters the user-defined &apos;Closed Arm (West)&apos; zone. Unit of measure: count</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s head enters the user-defined &apos;Closed Arm (West)&apos; zone. Unit: count</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: closed arm (west) - head entries</rdfs:label>
     </owl:Class>
     
@@ -382,7 +382,7 @@
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000029">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s head enters the user-defined &apos;Closed Arm (East)&apos; zone. Unit of measure: count</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s head enters the user-defined &apos;Closed Arm (East)&apos; zone. Unit: count</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: closed arm (east) - head entries</rdfs:label>
     </owl:Class>
     
@@ -392,7 +392,7 @@
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000030">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the total number of times the animal&apos;s head enters any of the designated closed arm zones (e.g., &apos;Closed Arm (West)&apos; and &apos;Closed Arm (East)&apos;). Unit of measure: count</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the total number of times the animal&apos;s head enters any of the designated closed arm zones (e.g., &apos;Closed Arm (West)&apos; and &apos;Closed Arm (East)&apos;). Unit: count</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: closed arm total head entries</rdfs:label>
     </owl:Class>
     
@@ -403,7 +403,7 @@
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000031">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal&apos;s body spends within the user-defined &apos;Closed Arm (West)&apos; zone. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal&apos;s body spends within the user-defined &apos;Closed Arm (West)&apos; zone. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: closed arm (west) - time</rdfs:label>
     </owl:Class>
     
@@ -414,7 +414,7 @@
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000032">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal&apos;s body spends within the user-defined &apos;Closed Arm (East)&apos; zone. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal&apos;s body spends within the user-defined &apos;Closed Arm (East)&apos; zone. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: closed arm (east) - time</rdfs:label>
     </owl:Class>
     
@@ -425,7 +425,7 @@
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000033">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the cumulative total duration the animal&apos;s body spends within any of the designated closed arm zones (e.g., &apos;Closed Arm (West)&apos; and &apos;Closed Arm (East)&apos;). Animals typically spend more time in these &apos;safer&apos; areas. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the cumulative total duration the animal&apos;s body spends within any of the designated closed arm zones (e.g., &apos;Closed Arm (West)&apos; and &apos;Closed Arm (East)&apos;). Animals typically spend more time in these &apos;safer&apos; areas. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: closed arm total time</rdfs:label>
     </owl:Class>
     
@@ -435,7 +435,7 @@
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000034">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this represents the percentage of the total test duration that the animal spends in any of the designated closed arm zones (e.g., &apos;Closed Arm (West)&apos; and &apos;Closed Arm (East)&apos;). Unit of measure: %</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this represents the percentage of the total test duration that the animal spends in any of the designated closed arm zones (e.g., &apos;Closed Arm (West)&apos; and &apos;Closed Arm (East)&apos;). Unit: %</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: closed arm total - percent time during test duration</rdfs:label>
     </owl:Class>
     
@@ -446,7 +446,7 @@
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000035">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000091"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined &apos;Closed Arm (West)&apos; zone. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined &apos;Closed Arm (West)&apos; zone. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: closed arm (west) - latency to first entry</rdfs:label>
     </owl:Class>
     
@@ -457,7 +457,7 @@
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000036">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000091"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined &apos;Closed Arm (East)&apos; zone. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined &apos;Closed Arm (East)&apos; zone. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: closed arm (east) - latency to first entry</rdfs:label>
     </owl:Class>
     
@@ -468,7 +468,7 @@
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000037">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000091"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into any of the designated closed arm zones (e.g., &apos;Closed Arm (West)&apos; or &apos;Closed Arm (East)&apos;). Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into any of the designated closed arm zones (e.g., &apos;Closed Arm (West)&apos; or &apos;Closed Arm (East)&apos;). Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: closed arm total latency to first entry</rdfs:label>
     </owl:Class>
     
@@ -479,7 +479,7 @@
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000038">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined &apos;Closed Arm (West)&apos; zone. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined &apos;Closed Arm (West)&apos; zone. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: closed arm (west) - time moving towards</rdfs:label>
     </owl:Class>
     
@@ -490,7 +490,7 @@
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000039">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined &apos;Closed Arm (East)&apos; zone. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined &apos;Closed Arm (East)&apos; zone. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: closed arm (east) - time moving towards</rdfs:label>
     </owl:Class>
     
@@ -501,7 +501,7 @@
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000040">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the cumulative duration the animal spends actively moving towards any of the designated closed arm zones (e.g., &apos;Closed Arm (West)&apos; or &apos;Closed Arm (East)&apos;). Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the cumulative duration the animal spends actively moving towards any of the designated closed arm zones (e.g., &apos;Closed Arm (West)&apos; or &apos;Closed Arm (East)&apos;). Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: closed arm total time moving towards</rdfs:label>
     </owl:Class>
     
@@ -512,7 +512,7 @@
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000041">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined &apos;Closed Arm (West)&apos; zone. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined &apos;Closed Arm (West)&apos; zone. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: closed arm (west) - time freezing</rdfs:label>
     </owl:Class>
     
@@ -523,7 +523,7 @@
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000042">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined &apos;Closed Arm (East)&apos; zone. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined &apos;Closed Arm (East)&apos; zone. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: closed arm (east) - time freezing</rdfs:label>
     </owl:Class>
     
@@ -534,7 +534,7 @@
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000043">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the cumulative duration the animal exhibits freezing behavior while within any of the designated closed arm zones (e.g., &apos;Closed Arm (West)&apos; or &apos;Closed Arm (East)&apos;). Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the cumulative duration the animal exhibits freezing behavior while within any of the designated closed arm zones (e.g., &apos;Closed Arm (West)&apos; or &apos;Closed Arm (East)&apos;). Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: closed arm total time freezing</rdfs:label>
     </owl:Class>
     
@@ -544,7 +544,7 @@
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000044">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s body fully enters the user-defined &apos;Center&apos; zone of the maze, typically from one of the arms. The center zone is the area where all four arms meet. Unit of measure: count</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s body fully enters the user-defined &apos;Center&apos; zone of the maze, typically from one of the arms. The center zone is the area where all four arms meet. Unit: count</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: center - entries</rdfs:label>
     </owl:Class>
     
@@ -554,7 +554,7 @@
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000045">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s head enters the user-defined &apos;Center&apos; zone of the maze. Unit of measure: count</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s head enters the user-defined &apos;Center&apos; zone of the maze. Unit: count</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: center - head entries</rdfs:label>
     </owl:Class>
     
@@ -565,7 +565,7 @@
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000046">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal&apos;s body spends within the user-defined &apos;Center&apos; zone. Time in the center can indicate decision-making or risk assessment. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal&apos;s body spends within the user-defined &apos;Center&apos; zone. Time in the center can indicate decision-making or risk assessment. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: center - time</rdfs:label>
     </owl:Class>
     
@@ -575,7 +575,7 @@
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000047">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this represents the percentage of the total test duration that the animal spends in the user-defined &apos;Center&apos; zone of the maze. Unit of measure: %</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this represents the percentage of the total test duration that the animal spends in the user-defined &apos;Center&apos; zone of the maze. Unit: %</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: center - percent time during test duration</rdfs:label>
     </owl:Class>
     
@@ -586,7 +586,7 @@
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000048">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000091"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined &apos;Center&apos; zone. If the animal starts in the center, this value may be zero or not applicable. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined &apos;Center&apos; zone. If the animal starts in the center, this value may be zero or not applicable. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: center - latency to first entry</rdfs:label>
     </owl:Class>
     
@@ -597,7 +597,7 @@
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000049">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined &apos;Center&apos; zone of the maze (e.g., from an arm). Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined &apos;Center&apos; zone of the maze (e.g., from an arm). Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: center - time moving towards</rdfs:label>
     </owl:Class>
     
@@ -608,7 +608,7 @@
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000050">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined &apos;Center&apos; zone of the maze. Freezing in this relatively exposed area can indicate high anxiety. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined &apos;Center&apos; zone of the maze. Freezing in this relatively exposed area can indicate high anxiety. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: center - time freezing</rdfs:label>
     </owl:Class>
     
@@ -639,7 +639,7 @@
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000053">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000004"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000162"/>
-        <obo:IAO_0000115>In the Fear-potentiated startle paradigm, this is the amplitude of the acoustic startle response (ASR) measured in response to a startle-eliciting stimulus (e.g., 95-dB white noise burst) prior to any fear conditioning procedures, typically assessed during habituation or pre-conditioning phase. This measurement serves as a reference point for later comparisons with post-conditioning startle responses. Unit of measure: arbitrary units or standardized score.</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Fear-potentiated startle paradigm, this is the amplitude of the acoustic startle response (ASR) measured in response to a startle-eliciting stimulus (e.g., 95-dB white noise burst) prior to any fear conditioning procedures, typically assessed during habituation or pre-conditioning phase. This measurement serves as a reference point for later comparisons with post-conditioning startle responses. Unit: arbitrary units or standardized score.</obo:IAO_0000115>
         <rdfs:label xml:lang="en">fear-potentiated startle: baseline acoustic startle response amplitude</rdfs:label>
     </owl:Class>
     
@@ -690,7 +690,7 @@
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000058">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000093"/>
-        <obo:IAO_0000115>Identifier for the specific Plexiglas enclosure or sound-attenuating chamber within the Fear-Potentiated Startle (FPS) apparatus (e.g., San Diego Instruments SR-Lab) in which a subject was tested for a given trial. Unit of measure: count or identifier string</obo:IAO_0000115>
+        <obo:IAO_0000115>Identifier for the specific Plexiglas enclosure or sound-attenuating chamber within the Fear-Potentiated Startle (FPS) apparatus (e.g., San Diego Instruments SR-Lab) in which a subject was tested for a given trial. Unit: count or identifier string</obo:IAO_0000115>
         <rdfs:label xml:lang="en">fear-potentiated startle: apparatus chamber identifier</rdfs:label>
     </owl:Class>
     
@@ -710,7 +710,7 @@
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000060">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000093"/>
-        <obo:IAO_0000115>The total number of data points (samples) recorded and analyzed for a single acoustic startle response, typically within a defined time window following stimulus onset (e.g., a 200-ms window as mentioned in the manuscript). Unit of measure: count</obo:IAO_0000115>
+        <obo:IAO_0000115>The total number of data points (samples) recorded and analyzed for a single acoustic startle response, typically within a defined time window following stimulus onset (e.g., a 200-ms window as mentioned in the manuscript). Unit: count</obo:IAO_0000115>
         <rdfs:label xml:lang="en">acoustic startle response: number of samples</rdfs:label>
     </owl:Class>
     
@@ -720,7 +720,7 @@
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000061">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000093"/>
-        <obo:IAO_0000115>The rate at which the analog startle response signal was digitized during data acquisition. Unit of measure: Hertz (Hz)</obo:IAO_0000115>
+        <obo:IAO_0000115>The rate at which the analog startle response signal was digitized during data acquisition. Unit: Hertz (Hz)</obo:IAO_0000115>
         <rdfs:label xml:lang="en">acoustic startle response: sampling rate</rdfs:label>
     </owl:Class>
     
@@ -731,7 +731,7 @@
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000062">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000004"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000162"/>
-        <obo:IAO_0000115>The amplitude of the digitized acoustic startle response signal at the very beginning (onset) of the defined analysis window (e.g., a 200-ms window) used to quantify the reflex. Unit of measure: millivolts (mV) or arbitrary units based on transducer calibration.</obo:IAO_0000115>
+        <obo:IAO_0000115>The amplitude of the digitized acoustic startle response signal at the very beginning (onset) of the defined analysis window (e.g., a 200-ms window) used to quantify the reflex. Unit: millivolts (mV) or arbitrary units based on transducer calibration.</obo:IAO_0000115>
         <rdfs:label xml:lang="en">acoustic startle response: startle window onset amplitude</rdfs:label>
     </owl:Class>
     
@@ -742,7 +742,7 @@
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000063">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000004"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000162"/>
-        <obo:IAO_0000115>The peak amplitude of the acoustic startle response (e.g., &apos;jump amplitude&apos;) detected within the defined analysis window (e.g., 200-ms window) for a given trial. Unit of measure: millivolts (mV) or arbitrary units.</obo:IAO_0000115>
+        <obo:IAO_0000115>The peak amplitude of the acoustic startle response (e.g., &apos;jump amplitude&apos;) detected within the defined analysis window (e.g., 200-ms window) for a given trial. Unit: millivolts (mV) or arbitrary units.</obo:IAO_0000115>
         <rdfs:label xml:lang="en">acoustic startle response: maximum amplitude</rdfs:label>
     </owl:Class>
     
@@ -753,7 +753,7 @@
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000064">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000004"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000091"/>
-        <obo:IAO_0000115>The latency from the onset of the startle-eliciting stimulus (or the beginning of the analysis window) to the occurrence of the maximum (peak) amplitude of the acoustic startle response. Unit of measure: milliseconds (ms)</obo:IAO_0000115>
+        <obo:IAO_0000115>The latency from the onset of the startle-eliciting stimulus (or the beginning of the analysis window) to the occurrence of the maximum (peak) amplitude of the acoustic startle response. Unit: milliseconds (ms)</obo:IAO_0000115>
         <rdfs:label xml:lang="en">acoustic startle response: time to maximum amplitude</rdfs:label>
     </owl:Class>
     
@@ -764,7 +764,7 @@
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000065">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000004"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000162"/>
-        <obo:IAO_0000115>The average amplitude of the digitized acoustic startle response signal calculated across the entire duration of the defined analysis window (e.g., 200-ms window). Unit of measure: millivolts (mV) or arbitrary units.</obo:IAO_0000115>
+        <obo:IAO_0000115>The average amplitude of the digitized acoustic startle response signal calculated across the entire duration of the defined analysis window (e.g., 200-ms window). Unit: millivolts (mV) or arbitrary units.</obo:IAO_0000115>
         <rdfs:label xml:lang="en">acoustic startle response: average amplitude</rdfs:label>
     </owl:Class>
     
@@ -797,7 +797,7 @@
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000092"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the time of the total test duration in seconds&apos;). Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the time of the total test duration in seconds&apos;). Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: test duration</rdfs:label>
     </owl:Class>
     
@@ -1927,7 +1927,7 @@
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000175">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000163"/>
-        <obo:IAO_0000115>The number of seconds the individual spent freezing during a given period of time. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>The number of seconds the individual spent freezing during a given period of time. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">contextual fear conditioning: time freezing</rdfs:label>
     </owl:Class>
     
@@ -1938,7 +1938,7 @@
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000176">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000163"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000164"/>
-        <obo:IAO_0000115>In the contextual fear conditioning paradigm, this is the time of the block duration in seconds. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the contextual fear conditioning paradigm, this is the time of the block duration in seconds. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">contextual fear conditioning: block duration</rdfs:label>
     </owl:Class>
     
@@ -2496,6 +2496,293 @@
     
 
 
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000231 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000231">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000101"/>
+        <obo:IAO_0000115>A parameter that specifies the technical settings, environmental conditions, or experimental design of a chemotaxis assay involving Caenorhabditis elegans.</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">C. elegans chemotaxis assay parameter</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000232 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000232">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000231"/>
+        <obo:IAO_0000115>A table containing the quantities and identities of all chemicals used as a chemoattractant (e.g., isoamyl alcohol, diacetyl) to elicit a directed movement response in C. elegans.</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">C. elegans chemotaxis assay parameter: chemoattractant mixture table</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000233 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000233">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000231"/>
+        <obo:IAO_0000115>The volume of the chemoattractant mixture pipetted onto the agar plate in a chemotaxis assay. Unit: microliters (μL).</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">C. elegans chemotaxis assay parameter: chemoattractant mixture volume</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000234 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000234">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000231"/>
+        <obo:IAO_0000115>The total time elapsed from the point at which C. elegans are placed on the assay plate until the movement is arrested or the final positions are recorded. Unit: minutes.</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">C. elegans chemotaxis assay parameter: assay duration</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000235 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000235">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000100"/>
+        <obo:IAO_0000115>A quantitative or qualitative value derived from a C. elegans chemotaxis assay, typically describing the efficiency or directionality of the animals&apos; movement toward or away from a chemical source.</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">C. elegans chemotaxis assay measurement</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000236 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000236">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000235"/>
+        <obo:IAO_0000115>A behavioral measurement of chemotactic efficiency defined as the ratio of the straight-line displacement toward the attractant to the total path length traveled by the organism. Values range from -1 to 1.</obo:IAO_0000115>
+        <oboInOwl:hasExactSynonym xml:lang="en">chemotactic ratio</oboInOwl:hasExactSynonym>
+        <rdfs:label xml:lang="en">C. elegans chemotaxis assay measurement: McCutcheon index</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000237 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000237">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000235"/>
+        <obo:IAO_0000115>The average speed of a C. elegans individual or population during the duration of the chemotaxis assay. Unit: micrometers per second (µm/s).</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">C. elegans chemotaxis assay measurement: mean velocity</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000238 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000238">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000076"/>
+        <obo:IAO_0000115>A specific genetic variant or line of an organism designated by the investigator, often containing unique mutations, transgenes, or genomic edits not yet categorized in a public repository.</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">investigator-defined strain</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000239 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000239">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000238"/>
+        <obo:IAO_0000115>A specific strain of Caenorhabditis elegans, identified by its genotype or a standard nomenclature (e.g., N2, CB4856), used in experimental procedures.</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">C. elegans strain</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000240 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000240">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000239"/>
+        <obo:IAO_0000115>A C. elegans strain with the genotype daf-22 (m130). This strain was originally obtained from the Caenorhabditis Genetics Center (CGC) as strain DR476 and subsequently outcrossed three times. [Source: https://doi.org/TBD]</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">BAB9001</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000241 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000241">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000239"/>
+        <obo:IAO_0000115>A C. elegans klp-6 rescue strain with the genotype klp-6 (my8); Pklp-6::GFP::KLP-6 (array, IndEx 9002). [Source: https://doi.org/TBD]</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">BAB9002</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000242 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000242">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000239"/>
+        <obo:IAO_0000115>A C. elegans strain with the genotype cil-7 (tm5848) I, exhibiting a him phenotype. This strain was obtained from the National BioResource Project (NBRP), Japan. [Source: https://doi.org/TBD]</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">TM5848</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000243 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000243">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000239"/>
+        <obo:IAO_0000115>A C. elegans strain with the genotype cil-7 (my61[cil-7::mNG])I; him-5(e1490) V. This strain was provided as a gift from the Maureen Barr lab. [Source: https://doi.org/TBD]</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">PT3602</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000244 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000244">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000239"/>
+        <obo:IAO_0000115>A C. elegans strain with the genotype PT3602; Pnlp-43_hCaspase nZ (array IndEx 9003). [Source: https://doi.org/TBD]</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">BAB9003</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000245 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000245">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000239"/>
+        <obo:IAO_0000115>A C. elegans strain with the genotype PT3602; Pklp-6_hCaspase Cz (array IndEx 9004). [Source: https://doi.org/TBD]</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">BAB9004</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000246 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000246">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000239"/>
+        <obo:IAO_0000115>A C. elegans strain with the genotype PT3602; Pnlp-43_hCaspase nZ (array IndEx 9003) and Pklp-6_hCaspase Cz (array IndEx 9004). [Source: https://doi.org/TBD]</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">BAB9005</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000247 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000247">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000001"/>
+        <obo:IAO_0000115>fluorescence imaging measurement</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">fluorescence imaging measurement</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000248 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000248">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000247"/>
+        <obo:IAO_0000115>Mean fluorescence intensity. Unit: arbitrary units (AU)</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">mean fluorescence intensity</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000249 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000249">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000247"/>
+        <obo:IAO_0000115>A quantitative measurement of the number of distinct fluorescent spots or puncta detected within a defined region of interest in a fluorescence image. Unit: count</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">fluorescent punctal count</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000250 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000250">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000080"/>
+        <obo:IAO_0000115>A specific parameter related to fluorescence imaging acquisition or assay.</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">fluorescence imaging parameter</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000251 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000251">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000250"/>
+        <obo:IAO_0000115>fluorescence target ontology identifier</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">fluorescence target ontology identifier</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000252 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000252">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000250"/>
+        <obo:IAO_0000115>fluorescence target name</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">fluorescence target name</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000253 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000253">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/format_1929"/>
+        <obo:IAO_0000115>A .dna file format designed for storing annotated DNA sequences, including linear/circular topology, features, primers, and enzyme sites.</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">SnapGene file format</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000254 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000254">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_637912"/>
+        <obo:IAO_0000115>A preparation of Escherichia coli strain OP50 that has been rendered non-viable through the application of heat, typically used as a non-proliferating food source in C. elegans assays.</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">Escherichia coli OP50: heat-killed</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000255 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000255">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000189"/>
+        <obo:IAO_0000115>Method used to transfer C. elegans whereby an M9 buffer is used to wash C. elegans off of an agar plate. Animals can then be transferred using a piper.</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">C. elegans transfer method: M9 buffer wash</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000256 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000256">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000189"/>
+        <obo:IAO_0000115>Method used to transfer C. elegans whereby a titanium pick is used to scoop animals off of an agar plate.</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">C. elegans transfer method: titanium pick</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000257 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000257">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000129"/>
+        <obo:IAO_0000115>A video recording capturing the behavior of C. elegans during a chemotaxis assay.</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">C. elegans chemotaxis assay: video recording</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000258 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000258">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCIT_C16856"/>
+        <obo:IAO_0000115>An image or video acquired using fluorescence microscopy.</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">fluorescence imaging data</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/NCBITaxon_637912 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_637912"/>
+    
+
+
     <!-- http://purl.obolibrary.org/obo/NCIT_C14184 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCIT_C14184"/>
@@ -2508,6 +2795,12 @@
     
 
 
+    <!-- http://purl.obolibrary.org/obo/NCIT_C16856 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCIT_C16856"/>
+    
+
+
     <!-- http://purl.obolibrary.org/obo/NCIT_C172272 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCIT_C172272"/>
@@ -2679,6 +2972,12 @@
     <!-- http://purl.obolibrary.org/obo/UBERON_0003883 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0003883"/>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/format_1929 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/format_1929"/>
 </rdf:RDF>
 
 
diff --git a/empty-full.json b/empty-full.json
index 1334dfd..c49b508 100644
--- a/empty-full.json
+++ b/empty-full.json
@@ -16,12 +16,12 @@
         "val" : "EMPTY by NDI is licensed under CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/). You are free to share (copy and redistribute the material in any medium or format) and adapt (remix, transform, and build upon the material) for any purpose, even commercially. You must give appropriate credit (by using the original ontology IRI for the whole ontology or original term IRIs for individual terms), provide a link to the license, and indicate if any changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use."
       }, {
         "pred" : "http://www.w3.org/2002/07/owl#versionInfo",
-        "val" : "2026-02-23"
+        "val" : "2026-04-04"
       }, {
         "pred" : "http://www.w3.org/2002/07/owl#versionInfo",
         "val" : "Release 2025-07-10"
       } ],
-      "version" : "http://purl.obolibrary.org/obo/empty/releases/2026-02-23/empty-full.json"
+      "version" : "http://purl.obolibrary.org/obo/empty/releases/2026-04-04/empty-full.json"
     },
     "nodes" : [ {
       "id" : "http://purl.obolibrary.org/obo/BFO_0000001",
@@ -129,7 +129,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "Elementary particle not affected by the strong force having a spin 1/2, a negative elementary charge and a rest mass of 0.000548579903(13) u, or 0.51099906(15) MeV."
+          "val" : "Elementary particle not affected by the strong force having a spin ½, a negative elementary charge and a rest mass of 0.000548579903(13) u, or 0.51099906(15) MeV."
         }
       }
     }, {
@@ -138,7 +138,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "Any bacterial metabolite produced during a metabolic reaction in Mycoplasma genitalium."
+          "val" : "Any bacterial metabolite produced during a metabolic reaction in <em>Mycoplasma genitalium</em>."
         }
       }
     }, {
@@ -165,7 +165,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "Any steroid that has beta-configuration at position 5."
+          "val" : "Any steroid that has β-configuration at position 5."
         }
       }
     }, {
@@ -174,7 +174,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "A Bronsted acid derived from one or more inorganic compounds. Inorganic acids (also known as mineral acids) form hydrons and conjugate base ions when dissolved in water."
+          "val" : "A Brønsted acid derived from one or more inorganic compounds. Inorganic acids (also known as mineral acids) form hydrons and conjugate base ions when dissolved in water."
         }
       }
     }, {
@@ -183,7 +183,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "Any member of a group of hydroxy steroids occuring in bile, where they are present as the sodium salts of their amides with glycine or taurine. In mammals bile acids almost invariably have 5beta-configuration, while in lower vertebrates, some bile acids, known as allo-bile acids, have 5alpha-configuration."
+          "val" : "Any member of a group of hydroxy steroids occuring in bile, where they are present as the sodium salts of their amides with glycine or taurine. In mammals bile acids almost invariably have 5β-configuration, while in lower vertebrates, some bile acids, known as <i>allo</i>-bile acids, have 5α-configuration."
         }
       }
     }, {
@@ -192,7 +192,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "Any main group molecular entity that is gaseous at standard temperature and pressure (STP; 0degreeC and 100 kPa)."
+          "val" : "Any main group molecular entity that is gaseous at standard temperature and pressure (STP; 0°C and 100 kPa)."
         }
       }
     }, {
@@ -214,7 +214,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "An antigenic epitope recognized by an anti-bilirubin monoclonal antibody designated 24G7. A substructure of bilirubin IXalpha, it is the region containing the oxo group at C-1, the methyl group at C-2, C-(4, 5, 6, 9), and N-21 and -22."
+          "val" : "An antigenic epitope recognized by an anti-bilirubin monoclonal antibody designated 24G7. A substructure of bilirubin IXα, it is the region containing the oxo group at C-1, the methyl group at C-2, C-(4, 5, 6, 9), and N-21 and -22."
         }
       }
     }, {
@@ -223,7 +223,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "An alpha-amino-acid anion that is the conjugate base of glutamic acid, having anionic carboxy groups and a cationic amino group"
+          "val" : "An α-amino-acid anion that is the conjugate base of glutamic acid, having anionic carboxy groups and a cationic amino group"
         }
       }
     }, {
@@ -253,6 +253,15 @@
           "val" : "A simple monocarboxylic acid containing two carbons."
         }
       }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/CHEBI_15378",
+      "lbl" : "hydron",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "The general name for the hydrogen nucleus, to be used without regard to the hydrogen nuclear mass (either for hydrogen in its natural abundance or where it is not desired to distinguish between the isotopes)."
+        }
+      }
     }, {
       "id" : "http://purl.obolibrary.org/obo/CHEBI_15379",
       "lbl" : "dioxygen",
@@ -263,7 +272,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "Aldehydic parent sugars (polyhydroxy aldehydes H[CH(OH)]nC(=O)H, n >= 2) and their intramolecular hemiacetals."
+          "val" : "Aldehydic parent sugars (polyhydroxy aldehydes H[CH(OH)]<small><sub><em>n</em></sub></small>C(=O)H, <em>n</em> ≥ 2) and their intramolecular hemiacetals."
         }
       }
     }, {
@@ -272,7 +281,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "Any alpha-amino acid having L-configuration at the alpha-carbon."
+          "val" : "Any α-amino acid having <small>L</small>-configuration at the α-carbon."
         }
       }
     }, {
@@ -290,7 +299,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "An optically active form of glutamic acid having D-configuration."
+          "val" : "An optically active form of glutamic acid having <small>D</small>-configuration."
         }
       }
     }, {
@@ -308,7 +317,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "An optically active form of glutamic acid having L-configuration."
+          "val" : "An optically active form of glutamic acid having <small>L</small>-configuration."
         }
       }
     }, {
@@ -368,7 +377,12 @@
     }, {
       "id" : "http://purl.obolibrary.org/obo/CHEBI_166902",
       "lbl" : "noradrenaline(1+)",
-      "type" : "CLASS"
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "An organic cation that is the conjugate acid of noradrenaline, obtained by protonation of the primary amino group; major species at pH 7.3."
+        }
+      }
     }, {
       "id" : "http://purl.obolibrary.org/obo/CHEBI_16733",
       "lbl" : "D-alpha-amino acid",
@@ -397,7 +411,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "A gamma-amino acid that is butanoic acid with the amino substituent located at C-4."
+          "val" : "A γ-amino acid that is butanoic acid with the amino substituent located at C-4."
         }
       }
     }, {
@@ -415,7 +429,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "A compound in which a carbonyl group is bonded to two carbon atoms: R2C=O (neither R may be H)."
+          "val" : "A compound in which a carbonyl group is bonded to two carbon atoms: R<small><sub>2</sub></small>C=O (neither R may be H)."
         }
       }
     }, {
@@ -460,7 +474,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "Any D-aldose having a chain of six carbon atoms in the molecule."
+          "val" : "Any <small>D</small>-aldose having a chain of six carbon atoms in the molecule."
         }
       }
     }, {
@@ -469,7 +483,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "A glucose with D-configuration."
+          "val" : "A glucose with <small>D</small>-configuration."
         }
       }
     }, {
@@ -541,7 +555,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "An alpha-amino acid that is glutaric acid bearing a single amino substituent at position 2."
+          "val" : "An α-amino acid that is glutaric acid bearing a single amino substituent at position 2."
         }
       }
     }, {
@@ -559,7 +573,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "The R-enantiomer of noradrenaline."
+          "val" : "The <i>R</i>-enantiomer of noradrenaline."
         }
       }
     }, {
@@ -616,7 +630,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "A molecular entity having an available pair of electrons capable of forming a covalent bond with a hydron (Bronsted base) or with the vacant orbital of some other molecular entity (Lewis base)."
+          "val" : "A molecular entity having an available pair of electrons capable of forming a covalent bond with a hydron (Brønsted base) or with the vacant orbital of some other molecular entity (Lewis base)."
         }
       }
     }, {
@@ -629,7 +643,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "Any compound that produces a peak used as reference frequency in the delta chemical shift scale."
+          "val" : "Any compound that produces a peak used as reference frequency in the δ chemical shift scale."
         }
       }
     }, {
@@ -672,6 +686,15 @@
           "val" : "Any constitutionally or isotopically distinct atom, molecule, ion, ion pair, radical, radical ion, complex, conformer etc., identifiable as a separately distinguishable entity."
         }
       }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/CHEBI_234420",
+      "lbl" : "(S)-noradrenaline(1+)",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "An organic cation that is the conjugate acid of (<i>S</i>)-noradrenaline, obtained by protonation of the primary amino group; major species at pH 7.3."
+        }
+      }
     }, {
       "id" : "http://purl.obolibrary.org/obo/CHEBI_23449",
       "lbl" : "cyclic peptide",
@@ -704,7 +727,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "An L-alpha-amino acid which is L-glutamic acid or any of the essential amino acids biosynthesised from it (glutamine, proline and arginine). A closed class."
+          "val" : "An <small>L</small>-α-amino acid which is <small>L</small>-glutamic acid or any of the essential amino acids biosynthesised from it (glutamine, proline and arginine). A closed class."
         }
       }
     }, {
@@ -713,7 +736,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "An EC 6.3.* (C-N bond-forming ligase) inhibitor that interferes with the action of glutamate--ammonia ligase (EC 6.3.1.2)."
+          "val" : "An EC 6.3.* (<em>C</em>‒<em>N</em> bond-forming ligase) inhibitor that interferes with the action of glutamate—ammonia ligase (EC 6.3.1.2)."
         }
       }
     }, {
@@ -789,7 +812,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "Hydroxides are chemical compounds containing a hydroxy group or salts containing hydroxide (OH(-))."
+          "val" : "Hydroxides are chemical compounds containing a hydroxy group or salts containing hydroxide (OH<small><sup>−</small></sup>)."
         }
       }
     }, {
@@ -798,7 +821,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "Any member of the class of 5beta-cholanic acids carrying at least one hydroxy group at unspecified position."
+          "val" : "Any member of the class of 5β-cholanic acids carrying at least one hydroxy group at unspecified position."
         }
       }
     }, {
@@ -903,7 +926,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "A group of neurotransmitters and neuromodulators that contain one amino group that is connected to an aromatic ring by ethylene group  (-CH2-CH2-). Monoamines are derived from the aromatic amino acids phenylalanine, tyrosine, histidine and tryptophan."
+          "val" : "A group of neurotransmitters and neuromodulators that contain one amino group that is connected to an aromatic ring by ethylene group  (‒CH<small><sub>2</sub></small>‒CH<small><sub>2</sub></small>‒). Monoamines are derived from the aromatic amino acids phenylalanine, tyrosine, histidine and tryptophan."
         }
       }
     }, {
@@ -1017,7 +1040,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "An aliphatic monocarboxylic acid with a chain length of less than C6. If any non-hydrocarbon substituent is present, the compound is not normally regarded as a short-chain fatty acid."
+          "val" : "An aliphatic monocarboxylic acid with a chain length of less than C<small><sub>6</sub></small>. If any non-hydrocarbon substituent is present, the compound is not normally regarded as a short-chain fatty acid."
         }
       }
     }, {
@@ -1140,7 +1163,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "A polydisperse, highly branched glucan composed of chains of D-glucopyranose residues in alpha(1->4) glycosidic linkage, joined together by alpha(1->6) glycosidic linkages. A small number of alpha(1->3) glycosidic linkages and some cumulative alpha(1->6) links also may occur. The branches in glycogen typically contain 8 to 12 glucose residues."
+          "val" : "A polydisperse, highly branched glucan composed of chains of <small>D</small>-glucopyranose residues in α(1→4) glycosidic linkage, joined together by α(1→6) glycosidic linkages. A small number of α(1→3) glycosidic linkages and some cumulative α(1→6) links also may occur. The branches in glycogen typically contain 8 to 12 glucose residues."
         }
       }
     }, {
@@ -1233,7 +1256,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "An alpha-amino-acid anion that is the conjugate base of L-glutamic acid, having anionic carboxy groups and a cationic amino group"
+          "val" : "An α-amino-acid anion that is the conjugate base of <small>L</small>-glutamic acid, having anionic carboxy groups and a cationic amino group"
         }
       }
     }, {
@@ -1242,7 +1265,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "An alpha-amino-acid anion that is the conjugate base of D-glutamic acid, having anionic carboxy groups and a cationic amino group"
+          "val" : "An α-amino-acid anion that is the conjugate base of <small>D</small>-glutamic acid, having anionic carboxy groups and a cationic amino group"
         }
       }
     }, {
@@ -1251,7 +1274,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "A dicarboxylic acid dianion that is the conjugate base of glutamate(1-)."
+          "val" : "A dicarboxylic acid dianion that is the conjugate base of glutamate(1−)."
         }
       }
     }, {
@@ -1260,7 +1283,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "An L-alpha-amino acid anion that is the dianion obtained by the deprotonation of the both the carboxy groups of L-glutamic acid."
+          "val" : "An <small>L</small>-α-amino acid anion that is the dianion obtained by the deprotonation of the both the carboxy groups of <small>L</small>-glutamic acid."
         }
       }
     }, {
@@ -1291,7 +1314,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "An gamma-amino acid anion resulting from the deprotonation of the carboxy group of gamma-aminobutyric acid."
+          "val" : "An γ-amino acid anion resulting from the deprotonation of the carboxy group of γ-aminobutyric acid."
         }
       }
     }, {
@@ -1309,7 +1332,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "Any member of a group of hydroxy-5beta-cholanic acids occuring in bile, where they are present as the sodium salts of their amides with glycine or taurine. In mammals bile acids almost invariably have 5beta-configuration."
+          "val" : "Any member of a group of hydroxy-5β-cholanic acids occuring in bile, where they are present as the sodium salts of their amides with glycine or taurine. In mammals bile acids almost invariably have 5β-configuration."
         }
       }
     }, {
@@ -1410,6 +1433,10 @@
           "val" : "A chemical entity constituting the smallest component of an element having the chemical properties of the element."
         }
       }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/CHEBI_33251",
+      "lbl" : "monoatomic hydrogen",
+      "type" : "CLASS"
     }, {
       "id" : "http://purl.obolibrary.org/obo/CHEBI_33252",
       "lbl" : "atomic nucleus",
@@ -1446,6 +1473,10 @@
           "val" : "A molecular entity all atoms of which have the same atomic number."
         }
       }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/CHEBI_33260",
+      "lbl" : "elemental hydrogen",
+      "type" : "CLASS"
     }, {
       "id" : "http://purl.obolibrary.org/obo/CHEBI_33262",
       "lbl" : "elemental oxygen",
@@ -1549,7 +1580,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "An ester of a carboxylic acid, R(1)C(=O)OR(2), where R(1) = H or organyl and R(2) = organyl."
+          "val" : "An ester of a carboxylic acid, R<small><sup>1</small></sup>C(=O)OR<small><sup>2</small></sup>, where R<small><sup>1</small></sup> = H or organyl and R<small><sup>2</small></sup> = organyl."
         }
       }
     }, {
@@ -1600,7 +1631,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "An amino-acid anion obtained by deprotonation of any alpha-amino acid."
+          "val" : "An amino-acid anion obtained by deprotonation of any α-amino acid."
         }
       }
     }, {
@@ -1622,7 +1653,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "Any compound containing an o-diphenol component."
+          "val" : "Any compound containing an <em>o</em>-diphenol component."
         }
       }
     }, {
@@ -1653,7 +1684,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "The S-enantiomer of noradrenaline."
+          "val" : "The <i>S</i>-enantiomer of noradrenaline."
         }
       }
     }, {
@@ -1662,7 +1693,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "A carbon oxoacid acid carrying at least one -C(=O)OH group and having the structure RC(=O)OH, where R is any any monovalent functional group. Carboxylic acids are the most common type of organic acid."
+          "val" : "A carbon oxoacid acid carrying at least one ‒C(=O)OH group and having the structure RC(=O)OH, where R is any any monovalent functional group. Carboxylic acids are the most common type of organic acid."
         }
       }
     }, {
@@ -1710,7 +1741,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "A cyclically conjugated molecular entity with a stability (due to delocalization) significantly greater than that of a hypothetical localized structure (e.g. Kekule structure) is said to possess aromatic character."
+          "val" : "A cyclically conjugated molecular entity with a stability (due to delocalization) significantly greater than that of a hypothetical localized structure (e.g. Kekulé structure) is said to possess aromatic character."
         }
       }
     }, {
@@ -1820,7 +1851,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "An amino acid in which the amino group is located on the carbon atom at the position alpha to the carboxy group."
+          "val" : "An amino acid in which the amino group is located on the carbon atom at the position α to the carboxy group."
         }
       }
     }, {
@@ -1829,7 +1860,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "A non-proteinogenic amino-acid in which the amino group is located on the carbon atom at the position gamma to the carboxy group."
+          "val" : "A non-proteinogenic amino-acid in which the amino group is located on the carbon atom at the position γ to the carboxy group."
         }
       }
     }, {
@@ -1856,7 +1887,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "An amino-acid residue derived from an alpha-amino acid."
+          "val" : "An amino-acid residue derived from an α-amino acid."
         }
       }
     }, {
@@ -1903,7 +1934,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "A heterocyclic compound formally derived from an arene by replacement of one or more methine (-C=) and/or vinylene (-CH=CH-) groups by trivalent or divalent heteroatoms, respectively, in such a way as to maintain the continuous pi-electron system characteristic of aromatic systems and a number of out-of-plane pi-electrons corresponding to the Hueckel rule (4n+2)."
+          "val" : "A heterocyclic compound formally derived from an arene by replacement of one or more methine (‒C=) and/or vinylene (‒CH=CH‒) groups by trivalent or divalent heteroatoms, respectively, in such a way as to maintain the continuous π-electron system characteristic of aromatic systems and a number of out-of-plane π-electrons corresponding to the Hückel rule (4<em>n</em>+2)."
         }
       }
     }, {
@@ -2019,7 +2050,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "A derivative of ammonium, NH4(+), in which all four of the hydrogens bonded to nitrogen have been replaced with univalent (usually organyl) groups."
+          "val" : "A derivative of ammonium, NH<small><sub>4</sub></small><small><sup>+</small></sup>, in which all four of the hydrogens bonded to nitrogen have been replaced with univalent (usually organyl) groups."
         }
       }
     }, {
@@ -2028,7 +2059,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "A derivative of ammonium, NH4(+), in which one (or more) of the hydrogens bonded to the nitrogen have been replaced with univalent organyl groups. The substituting carbon of the organyl group must not itself be directly attached to a heteroatom (thereby excluding protonated amides, hemiaminals, etc)."
+          "val" : "A derivative of ammonium, NH<small><sub>4</sub></small><small><sup>+</small></sup>, in which one (or more) of the hydrogens bonded to the nitrogen have been replaced with univalent organyl groups. The substituting carbon of the organyl group must not itself be directly attached to a heteroatom (thereby excluding protonated amides, hemiaminals, etc)."
         }
       }
     }, {
@@ -2077,7 +2108,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "Parent monosaccharides are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H-[CHOH]n-C(=O)[CHOH]m-H with three or more carbon atoms. The generic term 'monosaccharide' (as opposed to oligosaccharide or polysaccharide) denotes a single unit, without glycosidic connection to other such units. It includes aldoses, dialdoses, aldoketoses, ketoses and diketoses, as well as deoxy sugars, provided that the parent compound has a (potential) carbonyl group."
+          "val" : "Parent monosaccharides are polyhydroxy aldehydes H[CH(OH)]<small><sub><em>n</em></sub></small>C(=O)H or polyhydroxy ketones H‒[CHOH]<small><sub><em>n</em></sub></small>‒C(=O)[CHOH]<small><sub><em>m</em></sub></small>‒H with three or more carbon atoms. The generic term 'monosaccharide' (as opposed to oligosaccharide or polysaccharide) denotes a single unit, without glycosidic connection to other such units. It includes aldoses, dialdoses, aldoketoses, ketoses and diketoses, as well as deoxy sugars, provided that the parent compound has a (potential) carbonyl group."
         }
       }
     }, {
@@ -2138,7 +2169,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "An agent that selectively binds to and activates alpha-adrenergic receptors."
+          "val" : "An agent that selectively binds to and activates α-adrenergic receptors."
         }
       }
     }, {
@@ -2147,7 +2178,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "A negative ion consisting solely of carbon and oxygen  atoms, and therefore having the general formula CxOy(n-) for some integers x, y and n."
+          "val" : "A negative ion consisting solely of carbon and oxygen  atoms, and therefore having the general formula C<small><sub><em>x</em></sub></small>O<small><sub><em>y</em></sub></small><small><sup><em>n</em>−</small></sup> for some integers <em>x</em>, <em>y</em> and <em>n</em>."
         }
       }
     }, {
@@ -2251,7 +2282,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "Members of the class of cholanic acids based on a 5beta-cholane skeleton."
+          "val" : "Members of the class of cholanic acids based on a 5β-cholane skeleton."
         }
       }
     }, {
@@ -2273,7 +2304,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "Lepton is a fermion that does not experience the strong force (strong interaction). The term is derived from the Greek lambdaepsilonpitauomicronsigma (small, thin)."
+          "val" : "Lepton is a fermion that does not experience the strong force (strong interaction). The term is derived from the Greek λεπτοσ (small, thin)."
         }
       }
     }, {
@@ -2282,7 +2313,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "Baryon is a fermion that does experience the strong force (strong interaction). The term is derived from the Greek betaalpharhoupsilonsigma (heavy)."
+          "val" : "Baryon is a fermion that does experience the strong force (strong interaction). The term is derived from the Greek βαρυσ (heavy)."
         }
       }
     }, {
@@ -2476,7 +2507,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "An acid is a molecular entity capable of donating a hydron (Bronsted acid) or capable of forming a covalent bond with an electron pair (Lewis acid)."
+          "val" : "An acid is a molecular entity capable of donating a hydron (Brønsted acid) or capable of forming a covalent bond with an electron pair (Lewis acid)."
         }
       }
     }, {
@@ -2494,7 +2525,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "An amide of a carboxylic acid, having the structure RC(=O)NR2. The term is used as a suffix in systematic name formation to denote the -C(=O)NH2 group including its carbon atom."
+          "val" : "An amide of a carboxylic acid, having the structure RC(=O)NR<small><sub>2</sub></small>. The term is used as a suffix in systematic name formation to denote the ‒C(=O)NH<small><sub>2</sub></small> group including its carbon atom."
         }
       }
     }, {
@@ -2617,7 +2648,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "A molecular entity capable of donating a hydron to an acceptor (Bronsted base)."
+          "val" : "A molecular entity capable of donating a hydron to an acceptor (Brønsted base)."
         }
       }
     }, {
@@ -2626,7 +2657,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "A molecular entity capable of accepting a hydron from a donor (Bronsted acid)."
+          "val" : "A molecular entity capable of accepting a hydron from a donor (Brønsted acid)."
         }
       }
     }, {
@@ -2657,7 +2688,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "A glucopyranose having D-configuration."
+          "val" : "A glucopyranose having <small>D</small>-configuration."
         }
       }
     }, {
@@ -2666,7 +2697,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "A hexose that has D-configuration at position 5."
+          "val" : "A hexose that has <small>D</small>-configuration at position 5."
         }
       }
     }, {
@@ -2740,7 +2771,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "Any drug that acts on an alpha-adrenergic receptor."
+          "val" : "Any drug that acts on an α-adrenergic receptor."
         }
       }
     }, {
@@ -2943,7 +2974,12 @@
     }, {
       "id" : "http://purl.obolibrary.org/obo/CHEBI_52211",
       "lbl" : "physiological role",
-      "type" : "CLASS"
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "A biological role relating to the normal mechanisms and their interactions within a living system."
+        }
+      }
     }, {
       "id" : "http://purl.obolibrary.org/obo/CHEBI_52217",
       "lbl" : "pharmaceutical",
@@ -3040,7 +3076,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "Any fatty acid anion obtained by removal of a proton from the carboxy group of a short-chain fatty acid (chain length of less than C6)."
+          "val" : "Any fatty acid anion obtained by removal of a proton from the carboxy group of a short-chain fatty acid (chain length of less than C<small><sub>6</sub></small>)."
         }
       }
     }, {
@@ -3049,7 +3085,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "Any fatty acid anion in which there is no C-C unsaturation."
+          "val" : "Any fatty acid anion in which there is no C‒C unsaturation."
         }
       }
     }, {
@@ -3067,7 +3103,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "An organic anion of general formula RS(=O)2O(-) where R is an organyl group."
+          "val" : "An organic anion of general formula RS(=O)2O(−) where R is an organyl group."
         }
       }
     }, {
@@ -3112,7 +3148,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "Conjugate base of an L-alpha-amino acid arising from deprotonation of the C-1 carboxy group."
+          "val" : "Conjugate base of an <small>L</small>-α-amino acid arising from deprotonation of the C-1 carboxy group."
         }
       }
     }, {
@@ -3121,7 +3157,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "Zwitterionic form of an L-alpha-amino acid having an anionic carboxy group and a protonated amino group."
+          "val" : "Zwitterionic form of an <small>L</small>-α-amino acid having an anionic carboxy group and a protonated amino group."
         }
       }
     }, {
@@ -3130,7 +3166,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "Zwitterionic form of a D-alpha-amino acid having an anionic carboxy group and a protonated amino group."
+          "val" : "Zwitterionic form of a <small>D</small>-α-amino acid having an anionic carboxy group and a protonated amino group."
         }
       }
     }, {
@@ -3139,7 +3175,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "Zwitterionic form of gamma-aminobutyric acid having an anionic carboxy group and a protonated amino group."
+          "val" : "Zwitterionic form of γ-aminobutyric acid having an anionic carboxy group and a protonated amino group."
         }
       }
     }, {
@@ -3202,7 +3238,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "Any alpha-amino acid anion in which the parent amino acid has D-configuration."
+          "val" : "Any α-amino acid anion in which the parent amino acid has <small>D</small>-configuration."
         }
       }
     }, {
@@ -3337,7 +3373,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "An organic molecular entity containing a single carbon atom (C1)."
+          "val" : "An organic molecular entity containing a single carbon atom (C<small><sub>1</sub></small>)."
         }
       }
     }, {
@@ -3454,7 +3490,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "An amino-acid anion in which the amino group is situated gamma- to the carboxylate group."
+          "val" : "An amino-acid anion in which the amino group is situated γ- to the carboxylate group."
         }
       }
     }, {
@@ -3463,7 +3499,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "An organic cation that is the conjugate acid of (R)-noradrenaline, obtained by protonation of the priamry amino group; major species at pH 7.3."
+          "val" : "An organic cation that is the conjugate acid of (<i>R</i>)-noradrenaline, obtained by protonation of the primary amino group; major species at pH 7.3."
         }
       }
     }, {
@@ -3508,7 +3544,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "A ligase inhibitor that interferes with the action of a C-N bond-forming ligase (EC 6.3.*.*)."
+          "val" : "A ligase inhibitor that interferes with the action of a <em>C</em>‒<em>N</em> bond-forming ligase (EC 6.3.*.*)."
         }
       }
     }, {
@@ -3616,7 +3652,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "An EC 6.3.* (C-N bond-forming ligase) inhibitor that interferes with the action of any acid-ammonia (or amine) ligase (EC 6.3.1.*)."
+          "val" : "An EC 6.3.* (<em>C</em>‒<em>N</em> bond-forming ligase) inhibitor that interferes with the action of any acid-ammonia (or amine) ligase (EC 6.3.1.*)."
         }
       }
     }, {
@@ -3724,7 +3760,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "An amino acid-zwitterion obtained by transfer of a proton from the carboxy to the amino group of any alpha-amino acid; major species at pH 7.3."
+          "val" : "An amino acid-zwitterion obtained by transfer of a proton from the carboxy to the amino group of any α-amino acid; major species at pH 7.3."
         }
       }
     }, {
@@ -3796,7 +3832,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "Any of the 23 alpha-amino acids that are precursors to proteins, and are incorporated into proteins during translation. The group includes the 20 amino acids encoded by the nuclear genes of eukaryotes together with selenocysteine, pyrrolysine, and N-formylmethionine. Apart from glycine, which is non-chiral, all have L configuration."
+          "val" : "Any of the 23 α-amino acids that are precursors to proteins, and are incorporated into proteins during translation. The group includes the 20 amino acids encoded by the nuclear genes of eukaryotes together with selenocysteine, pyrrolysine, and <em>N</em>-formylmethionine. Apart from glycine, which is non-chiral, all have <small>L</small> configuration."
         }
       }
     }, {
@@ -3814,7 +3850,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "Any  alpha-amino acid which is not a member of the group of 23 proteinogenic amino acids."
+          "val" : "Any  α-amino acid which is not a member of the group of 23 proteinogenic amino acids."
         }
       }
     }, {
@@ -7724,7 +7760,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's body (typically defined by its center point or a significant portion) fully enters the user-defined zone designated as 'Open Arm (North)'. The 'Open Arm (North)' is one of the two open arms, distinguished by its assigned 'north' orientation or designation in the experimental setup. Unit of measure: count"
+          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's body (typically defined by its center point or a significant portion) fully enters the user-defined zone designated as 'Open Arm (North)'. The 'Open Arm (North)' is one of the two open arms, distinguished by its assigned 'north' orientation or designation in the experimental setup. Unit: count"
         }
       }
     }, {
@@ -7733,7 +7769,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's body (typically defined by its center point or a significant portion) fully enters the user-defined zone designated as 'Open Arm (South)'. The 'Open Arm (South)' is one of the two open arms, distinguished by its assigned 'south' orientation or designation in the experimental setup. Unit of measure: count"
+          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's body (typically defined by its center point or a significant portion) fully enters the user-defined zone designated as 'Open Arm (South)'. The 'Open Arm (South)' is one of the two open arms, distinguished by its assigned 'south' orientation or designation in the experimental setup. Unit: count"
         }
       }
     }, {
@@ -7742,7 +7778,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this represents the total number of times the animal's body (typically defined by its center point or a significant portion) fully enters the designated open arm zones (e.g., 'Open Arm (North)' and 'Open Arm (South)'). It is a common measure of exploration and anxiety. Unit of measure: count"
+          "val" : "In the Elevated Plus Maze task, this represents the total number of times the animal's body (typically defined by its center point or a significant portion) fully enters the designated open arm zones (e.g., 'Open Arm (North)' and 'Open Arm (South)'). It is a common measure of exploration and anxiety. Unit: count"
         }
       }
     }, {
@@ -7751,7 +7787,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's head (specifically tracked by the software) enters the user-defined 'Open Arm (North)' zone, irrespective of full body entry. This can indicate risk assessment or tentative exploration of the arm designated as 'north'. Unit of measure: count"
+          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's head (specifically tracked by the software) enters the user-defined 'Open Arm (North)' zone, irrespective of full body entry. This can indicate risk assessment or tentative exploration of the arm designated as 'north'. Unit: count"
         }
       }
     }, {
@@ -7760,7 +7796,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's head (specifically tracked by the software) enters the user-defined 'Open Arm (South)' zone, irrespective of full body entry, often reflecting cautious exploration of the open arm designated as 'south'. Unit of measure: count"
+          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's head (specifically tracked by the software) enters the user-defined 'Open Arm (South)' zone, irrespective of full body entry, often reflecting cautious exploration of the open arm designated as 'south'. Unit: count"
         }
       }
     }, {
@@ -7769,7 +7805,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this is the total number of times the animal's head (specifically tracked by the software) enters any of the designated open arm zones (e.g., 'Open Arm (North)' and 'Open Arm (South)'), considered an indicator of risk-assessment behavior. Unit of measure: count"
+          "val" : "In the Elevated Plus Maze task, this is the total number of times the animal's head (specifically tracked by the software) enters any of the designated open arm zones (e.g., 'Open Arm (North)' and 'Open Arm (South)'), considered an indicator of risk-assessment behavior. Unit: count"
         }
       }
     }, {
@@ -7778,7 +7814,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Open Arm (North)' zone. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Open Arm (North)' zone. Unit: seconds"
         }
       }
     }, {
@@ -7787,7 +7823,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Open Arm (South)' zone. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Open Arm (South)' zone. Unit: seconds"
         }
       }
     }, {
@@ -7796,7 +7832,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this is the cumulative total duration the animal's body spends within any of the designated open arm zones (e.g., 'Open Arm (North)' and 'Open Arm (South)'). Less time is generally indicative of higher anxiety. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this is the cumulative total duration the animal's body spends within any of the designated open arm zones (e.g., 'Open Arm (North)' and 'Open Arm (South)'). Less time is generally indicative of higher anxiety. Unit: seconds"
         }
       }
     }, {
@@ -7805,7 +7841,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this represents the percentage of the total test duration that the animal spends in any of the designated open arm zones (e.g., 'Open Arm (North)' and 'Open Arm (South)'). Unit of measure: %"
+          "val" : "In the Elevated Plus Maze task, this represents the percentage of the total test duration that the animal spends in any of the designated open arm zones (e.g., 'Open Arm (North)' and 'Open Arm (South)'). Unit: %"
         }
       }
     }, {
@@ -7814,7 +7850,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Open Arm (North)' zone. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Open Arm (North)' zone. Unit: seconds"
         }
       }
     }, {
@@ -7823,7 +7859,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Open Arm (South)' zone. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Open Arm (South)' zone. Unit: seconds"
         }
       }
     }, {
@@ -7832,7 +7868,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into any of the designated open arm zones (e.g., 'Open Arm (North)' or 'Open Arm (South)'). Longer latencies often suggest higher anxiety. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into any of the designated open arm zones (e.g., 'Open Arm (North)' or 'Open Arm (South)'). Longer latencies often suggest higher anxiety. Unit: seconds"
         }
       }
     }, {
@@ -7841,7 +7877,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Open Arm (North)' zone, as detected by the tracking software. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Open Arm (North)' zone, as detected by the tracking software. Unit: seconds"
         }
       }
     }, {
@@ -7850,7 +7886,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Open Arm (South)' zone, as detected by the tracking software. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Open Arm (South)' zone, as detected by the tracking software. Unit: seconds"
         }
       }
     }, {
@@ -7859,7 +7895,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this is the cumulative duration the animal spends actively moving towards any of the designated open arm zones (e.g., 'Open Arm (North)' or 'Open Arm (South)'), reflecting approach motivation. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this is the cumulative duration the animal spends actively moving towards any of the designated open arm zones (e.g., 'Open Arm (North)' or 'Open Arm (South)'), reflecting approach motivation. Unit: seconds"
         }
       }
     }, {
@@ -7868,7 +7904,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior (a state of immobility except for respiratory movements) while within the user-defined 'Open Arm (North)' zone. Freezing is a common fear response. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior (a state of immobility except for respiratory movements) while within the user-defined 'Open Arm (North)' zone. Freezing is a common fear response. Unit: seconds"
         }
       }
     }, {
@@ -7877,7 +7913,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined 'Open Arm (South)' zone. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined 'Open Arm (South)' zone. Unit: seconds"
         }
       }
     }, {
@@ -7886,7 +7922,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this is the cumulative duration the animal exhibits freezing behavior while within any of the designated open arm zones (e.g., 'Open Arm (North)' or 'Open Arm (South)'), indicating fear or anxiety. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this is the cumulative duration the animal exhibits freezing behavior while within any of the designated open arm zones (e.g., 'Open Arm (North)' or 'Open Arm (South)'), indicating fear or anxiety. Unit: seconds"
         }
       }
     }, {
@@ -7895,7 +7931,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's body fully enters the user-defined 'Closed Arm (West)' zone, representing the enclosed arm designated as 'west'. Unit of measure: count"
+          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's body fully enters the user-defined 'Closed Arm (West)' zone, representing the enclosed arm designated as 'west'. Unit: count"
         }
       }
     }, {
@@ -7904,7 +7940,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's body fully enters the user-defined 'Closed Arm (East)' zone, representing the enclosed arm designated as 'east'. Unit of measure: count"
+          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's body fully enters the user-defined 'Closed Arm (East)' zone, representing the enclosed arm designated as 'east'. Unit: count"
         }
       }
     }, {
@@ -7913,7 +7949,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this is the total number of times the animal's body fully enters any of the designated closed arm zones (e.g., 'Closed Arm (West)' and 'Closed Arm (East)'). It is often used as an indicator of general locomotor activity. Unit of measure: count"
+          "val" : "In the Elevated Plus Maze task, this is the total number of times the animal's body fully enters any of the designated closed arm zones (e.g., 'Closed Arm (West)' and 'Closed Arm (East)'). It is often used as an indicator of general locomotor activity. Unit: count"
         }
       }
     }, {
@@ -7922,7 +7958,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's head enters the user-defined 'Closed Arm (West)' zone. Unit of measure: count"
+          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's head enters the user-defined 'Closed Arm (West)' zone. Unit: count"
         }
       }
     }, {
@@ -7931,7 +7967,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's head enters the user-defined 'Closed Arm (East)' zone. Unit of measure: count"
+          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's head enters the user-defined 'Closed Arm (East)' zone. Unit: count"
         }
       }
     }, {
@@ -7940,7 +7976,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this is the total number of times the animal's head enters any of the designated closed arm zones (e.g., 'Closed Arm (West)' and 'Closed Arm (East)'). Unit of measure: count"
+          "val" : "In the Elevated Plus Maze task, this is the total number of times the animal's head enters any of the designated closed arm zones (e.g., 'Closed Arm (West)' and 'Closed Arm (East)'). Unit: count"
         }
       }
     }, {
@@ -7949,7 +7985,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Closed Arm (West)' zone. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Closed Arm (West)' zone. Unit: seconds"
         }
       }
     }, {
@@ -7958,7 +7994,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Closed Arm (East)' zone. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Closed Arm (East)' zone. Unit: seconds"
         }
       }
     }, {
@@ -7967,7 +8003,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this is the cumulative total duration the animal's body spends within any of the designated closed arm zones (e.g., 'Closed Arm (West)' and 'Closed Arm (East)'). Animals typically spend more time in these 'safer' areas. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this is the cumulative total duration the animal's body spends within any of the designated closed arm zones (e.g., 'Closed Arm (West)' and 'Closed Arm (East)'). Animals typically spend more time in these 'safer' areas. Unit: seconds"
         }
       }
     }, {
@@ -7976,7 +8012,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this represents the percentage of the total test duration that the animal spends in any of the designated closed arm zones (e.g., 'Closed Arm (West)' and 'Closed Arm (East)'). Unit of measure: %"
+          "val" : "In the Elevated Plus Maze task, this represents the percentage of the total test duration that the animal spends in any of the designated closed arm zones (e.g., 'Closed Arm (West)' and 'Closed Arm (East)'). Unit: %"
         }
       }
     }, {
@@ -7985,7 +8021,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Closed Arm (West)' zone. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Closed Arm (West)' zone. Unit: seconds"
         }
       }
     }, {
@@ -7994,7 +8030,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Closed Arm (East)' zone. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Closed Arm (East)' zone. Unit: seconds"
         }
       }
     }, {
@@ -8003,7 +8039,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into any of the designated closed arm zones (e.g., 'Closed Arm (West)' or 'Closed Arm (East)'). Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into any of the designated closed arm zones (e.g., 'Closed Arm (West)' or 'Closed Arm (East)'). Unit: seconds"
         }
       }
     }, {
@@ -8012,7 +8048,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Closed Arm (West)' zone. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Closed Arm (West)' zone. Unit: seconds"
         }
       }
     }, {
@@ -8021,7 +8057,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Closed Arm (East)' zone. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Closed Arm (East)' zone. Unit: seconds"
         }
       }
     }, {
@@ -8030,7 +8066,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this is the cumulative duration the animal spends actively moving towards any of the designated closed arm zones (e.g., 'Closed Arm (West)' or 'Closed Arm (East)'). Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this is the cumulative duration the animal spends actively moving towards any of the designated closed arm zones (e.g., 'Closed Arm (West)' or 'Closed Arm (East)'). Unit: seconds"
         }
       }
     }, {
@@ -8039,7 +8075,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined 'Closed Arm (West)' zone. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined 'Closed Arm (West)' zone. Unit: seconds"
         }
       }
     }, {
@@ -8048,7 +8084,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined 'Closed Arm (East)' zone. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined 'Closed Arm (East)' zone. Unit: seconds"
         }
       }
     }, {
@@ -8057,7 +8093,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this is the cumulative duration the animal exhibits freezing behavior while within any of the designated closed arm zones (e.g., 'Closed Arm (West)' or 'Closed Arm (East)'). Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this is the cumulative duration the animal exhibits freezing behavior while within any of the designated closed arm zones (e.g., 'Closed Arm (West)' or 'Closed Arm (East)'). Unit: seconds"
         }
       }
     }, {
@@ -8066,7 +8102,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's body fully enters the user-defined 'Center' zone of the maze, typically from one of the arms. The center zone is the area where all four arms meet. Unit of measure: count"
+          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's body fully enters the user-defined 'Center' zone of the maze, typically from one of the arms. The center zone is the area where all four arms meet. Unit: count"
         }
       }
     }, {
@@ -8075,7 +8111,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's head enters the user-defined 'Center' zone of the maze. Unit of measure: count"
+          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's head enters the user-defined 'Center' zone of the maze. Unit: count"
         }
       }
     }, {
@@ -8084,7 +8120,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Center' zone. Time in the center can indicate decision-making or risk assessment. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Center' zone. Time in the center can indicate decision-making or risk assessment. Unit: seconds"
         }
       }
     }, {
@@ -8093,7 +8129,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this represents the percentage of the total test duration that the animal spends in the user-defined 'Center' zone of the maze. Unit of measure: %"
+          "val" : "In the Elevated Plus Maze task, this represents the percentage of the total test duration that the animal spends in the user-defined 'Center' zone of the maze. Unit: %"
         }
       }
     }, {
@@ -8102,7 +8138,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Center' zone. If the animal starts in the center, this value may be zero or not applicable. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Center' zone. If the animal starts in the center, this value may be zero or not applicable. Unit: seconds"
         }
       }
     }, {
@@ -8111,7 +8147,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Center' zone of the maze (e.g., from an arm). Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Center' zone of the maze (e.g., from an arm). Unit: seconds"
         }
       }
     }, {
@@ -8120,7 +8156,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined 'Center' zone of the maze. Freezing in this relatively exposed area can indicate high anxiety. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined 'Center' zone of the maze. Freezing in this relatively exposed area can indicate high anxiety. Unit: seconds"
         }
       }
     }, {
@@ -8147,7 +8183,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Fear-potentiated startle paradigm, this is the amplitude of the acoustic startle response (ASR) measured in response to a startle-eliciting stimulus (e.g., 95-dB white noise burst) prior to any fear conditioning procedures, typically assessed during habituation or pre-conditioning phase. This measurement serves as a reference point for later comparisons with post-conditioning startle responses. Unit of measure: arbitrary units or standardized score."
+          "val" : "In the Fear-potentiated startle paradigm, this is the amplitude of the acoustic startle response (ASR) measured in response to a startle-eliciting stimulus (e.g., 95-dB white noise burst) prior to any fear conditioning procedures, typically assessed during habituation or pre-conditioning phase. This measurement serves as a reference point for later comparisons with post-conditioning startle responses. Unit: arbitrary units or standardized score."
         }
       }
     }, {
@@ -8192,7 +8228,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "Identifier for the specific Plexiglas enclosure or sound-attenuating chamber within the Fear-Potentiated Startle (FPS) apparatus (e.g., San Diego Instruments SR-Lab) in which a subject was tested for a given trial. Unit of measure: count or identifier string"
+          "val" : "Identifier for the specific Plexiglas enclosure or sound-attenuating chamber within the Fear-Potentiated Startle (FPS) apparatus (e.g., San Diego Instruments SR-Lab) in which a subject was tested for a given trial. Unit: count or identifier string"
         }
       }
     }, {
@@ -8210,7 +8246,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "The total number of data points (samples) recorded and analyzed for a single acoustic startle response, typically within a defined time window following stimulus onset (e.g., a 200-ms window as mentioned in the manuscript). Unit of measure: count"
+          "val" : "The total number of data points (samples) recorded and analyzed for a single acoustic startle response, typically within a defined time window following stimulus onset (e.g., a 200-ms window as mentioned in the manuscript). Unit: count"
         }
       }
     }, {
@@ -8219,7 +8255,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "The rate at which the analog startle response signal was digitized during data acquisition. Unit of measure: Hertz (Hz)"
+          "val" : "The rate at which the analog startle response signal was digitized during data acquisition. Unit: Hertz (Hz)"
         }
       }
     }, {
@@ -8228,7 +8264,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "The amplitude of the digitized acoustic startle response signal at the very beginning (onset) of the defined analysis window (e.g., a 200-ms window) used to quantify the reflex. Unit of measure: millivolts (mV) or arbitrary units based on transducer calibration."
+          "val" : "The amplitude of the digitized acoustic startle response signal at the very beginning (onset) of the defined analysis window (e.g., a 200-ms window) used to quantify the reflex. Unit: millivolts (mV) or arbitrary units based on transducer calibration."
         }
       }
     }, {
@@ -8237,7 +8273,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "The peak amplitude of the acoustic startle response (e.g., 'jump amplitude') detected within the defined analysis window (e.g., 200-ms window) for a given trial. Unit of measure: millivolts (mV) or arbitrary units."
+          "val" : "The peak amplitude of the acoustic startle response (e.g., 'jump amplitude') detected within the defined analysis window (e.g., 200-ms window) for a given trial. Unit: millivolts (mV) or arbitrary units."
         }
       }
     }, {
@@ -8246,7 +8282,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "The latency from the onset of the startle-eliciting stimulus (or the beginning of the analysis window) to the occurrence of the maximum (peak) amplitude of the acoustic startle response. Unit of measure: milliseconds (ms)"
+          "val" : "The latency from the onset of the startle-eliciting stimulus (or the beginning of the analysis window) to the occurrence of the maximum (peak) amplitude of the acoustic startle response. Unit: milliseconds (ms)"
         }
       }
     }, {
@@ -8255,7 +8291,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "The average amplitude of the digitized acoustic startle response signal calculated across the entire duration of the defined analysis window (e.g., 200-ms window). Unit of measure: millivolts (mV) or arbitrary units."
+          "val" : "The average amplitude of the digitized acoustic startle response signal calculated across the entire duration of the defined analysis window (e.g., 200-ms window). Unit: millivolts (mV) or arbitrary units."
         }
       }
     }, {
@@ -8282,7 +8318,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this is the time of the total test duration in seconds'). Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this is the time of the total test duration in seconds'). Unit: seconds"
         }
       }
     }, {
@@ -9259,7 +9295,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "The number of seconds the individual spent freezing during a given period of time. Unit of measure: seconds"
+          "val" : "The number of seconds the individual spent freezing during a given period of time. Unit: seconds"
         }
       }
     }, {
@@ -9268,7 +9304,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the contextual fear conditioning paradigm, this is the time of the block duration in seconds. Unit of measure: seconds"
+          "val" : "In the contextual fear conditioning paradigm, this is the time of the block duration in seconds. Unit: seconds"
         }
       }
     }, {
@@ -9746,6 +9782,262 @@
           "val" : "A digital file for which the format, encoding, or origin cannot be definitively identified by the system or investigator, necessitating further manual review or specialized software for interpretation."
         }
       }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000231",
+      "lbl" : "C. elegans chemotaxis assay parameter",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "A parameter that specifies the technical settings, environmental conditions, or experimental design of a chemotaxis assay involving Caenorhabditis elegans."
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000232",
+      "lbl" : "C. elegans chemotaxis assay parameter: chemoattractant mixture table",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "A table containing the quantities and identities of all chemicals used as a chemoattractant (e.g., isoamyl alcohol, diacetyl) to elicit a directed movement response in C. elegans."
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000233",
+      "lbl" : "C. elegans chemotaxis assay parameter: chemoattractant mixture volume",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "The volume of the chemoattractant mixture pipetted onto the agar plate in a chemotaxis assay. Unit: microliters (μL)."
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000234",
+      "lbl" : "C. elegans chemotaxis assay parameter: assay duration",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "The total time elapsed from the point at which C. elegans are placed on the assay plate until the movement is arrested or the final positions are recorded. Unit: minutes."
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000235",
+      "lbl" : "C. elegans chemotaxis assay measurement",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "A quantitative or qualitative value derived from a C. elegans chemotaxis assay, typically describing the efficiency or directionality of the animals' movement toward or away from a chemical source."
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000236",
+      "lbl" : "C. elegans chemotaxis assay measurement: McCutcheon index",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "A behavioral measurement of chemotactic efficiency defined as the ratio of the straight-line displacement toward the attractant to the total path length traveled by the organism. Values range from -1 to 1."
+        },
+        "synonyms" : [ {
+          "pred" : "hasExactSynonym",
+          "val" : "chemotactic ratio"
+        } ]
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000237",
+      "lbl" : "C. elegans chemotaxis assay measurement: mean velocity",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "The average speed of a C. elegans individual or population during the duration of the chemotaxis assay. Unit: micrometers per second (µm/s)."
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000238",
+      "lbl" : "investigator-defined strain",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "A specific genetic variant or line of an organism designated by the investigator, often containing unique mutations, transgenes, or genomic edits not yet categorized in a public repository."
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000239",
+      "lbl" : "C. elegans strain",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "A specific strain of Caenorhabditis elegans, identified by its genotype or a standard nomenclature (e.g., N2, CB4856), used in experimental procedures."
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000240",
+      "lbl" : "BAB9001",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "A C. elegans strain with the genotype daf-22 (m130). This strain was originally obtained from the Caenorhabditis Genetics Center (CGC) as strain DR476 and subsequently outcrossed three times. [Source: https://doi.org/TBD]"
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000241",
+      "lbl" : "BAB9002",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "A C. elegans klp-6 rescue strain with the genotype klp-6 (my8); Pklp-6::GFP::KLP-6 (array, IndEx 9002). [Source: https://doi.org/TBD]"
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000242",
+      "lbl" : "TM5848",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "A C. elegans strain with the genotype cil-7 (tm5848) I, exhibiting a him phenotype. This strain was obtained from the National BioResource Project (NBRP), Japan. [Source: https://doi.org/TBD]"
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000243",
+      "lbl" : "PT3602",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "A C. elegans strain with the genotype cil-7 (my61[cil-7::mNG])I; him-5(e1490) V. This strain was provided as a gift from the Maureen Barr lab. [Source: https://doi.org/TBD]"
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000244",
+      "lbl" : "BAB9003",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "A C. elegans strain with the genotype PT3602; Pnlp-43_hCaspase nZ (array IndEx 9003). [Source: https://doi.org/TBD]"
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000245",
+      "lbl" : "BAB9004",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "A C. elegans strain with the genotype PT3602; Pklp-6_hCaspase Cz (array IndEx 9004). [Source: https://doi.org/TBD]"
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000246",
+      "lbl" : "BAB9005",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "A C. elegans strain with the genotype PT3602; Pnlp-43_hCaspase nZ (array IndEx 9003) and Pklp-6_hCaspase Cz (array IndEx 9004). [Source: https://doi.org/TBD]"
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000247",
+      "lbl" : "fluorescence imaging measurement",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "fluorescence imaging measurement"
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000248",
+      "lbl" : "mean fluorescence intensity",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "Mean fluorescence intensity. Unit: arbitrary units (AU)"
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000249",
+      "lbl" : "fluorescent punctal count",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "A quantitative measurement of the number of distinct fluorescent spots or puncta detected within a defined region of interest in a fluorescence image. Unit: count"
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000250",
+      "lbl" : "fluorescence imaging parameter",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "A specific parameter related to fluorescence imaging acquisition or assay."
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000251",
+      "lbl" : "fluorescence target ontology identifier",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "fluorescence target ontology identifier"
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000252",
+      "lbl" : "fluorescence target name",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "fluorescence target name"
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000253",
+      "lbl" : "SnapGene file format",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "A .dna file format designed for storing annotated DNA sequences, including linear/circular topology, features, primers, and enzyme sites."
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000254",
+      "lbl" : "Escherichia coli OP50: heat-killed",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "A preparation of Escherichia coli strain OP50 that has been rendered non-viable through the application of heat, typically used as a non-proliferating food source in C. elegans assays."
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000255",
+      "lbl" : "C. elegans transfer method: M9 buffer wash",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "Method used to transfer C. elegans whereby an M9 buffer is used to wash C. elegans off of an agar plate. Animals can then be transferred using a piper."
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000256",
+      "lbl" : "C. elegans transfer method: titanium pick",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "Method used to transfer C. elegans whereby a titanium pick is used to scoop animals off of an agar plate."
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000257",
+      "lbl" : "C. elegans chemotaxis assay: video recording",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "A video recording capturing the behavior of C. elegans during a chemotaxis assay."
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000258",
+      "lbl" : "fluorescence imaging data",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "An image or video acquired using fluorescence microscopy."
+        }
+      }
     }, {
       "id" : "http://purl.obolibrary.org/obo/ENVO_00000447",
       "type" : "CLASS"
@@ -15958,6 +16250,10 @@
       "id" : "http://purl.obolibrary.org/obo/GO_0010070",
       "lbl" : "zygote asymmetric cell division",
       "type" : "CLASS"
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/GO_0010155",
+      "lbl" : "regulation of proton transport",
+      "type" : "CLASS"
     }, {
       "id" : "http://purl.obolibrary.org/obo/GO_0010160",
       "lbl" : "formation of animal organ boundary",
@@ -16958,14 +17254,6 @@
       "id" : "http://purl.obolibrary.org/obo/GO_0014874",
       "lbl" : "response to stimulus involved in regulation of muscle adaptation",
       "type" : "CLASS"
-    }, {
-      "id" : "http://purl.obolibrary.org/obo/GO_0014878",
-      "lbl" : "response to electrical stimulus involved in regulation of muscle adaptation",
-      "type" : "CLASS"
-    }, {
-      "id" : "http://purl.obolibrary.org/obo/GO_0014879",
-      "lbl" : "detection of electrical stimulus involved in regulation of muscle adaptation",
-      "type" : "CLASS"
     }, {
       "id" : "http://purl.obolibrary.org/obo/GO_0014887",
       "lbl" : "cardiac muscle adaptation",
@@ -17024,6 +17312,19 @@
           "val" : "ion transporter activity"
         } ]
       }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/GO_0015078",
+      "lbl" : "proton transmembrane transporter activity",
+      "type" : "CLASS",
+      "meta" : {
+        "synonyms" : [ {
+          "pred" : "hasExactSynonym",
+          "val" : "hydrogen ion transmembrane transporter activity"
+        }, {
+          "pred" : "hasExactSynonym",
+          "val" : "proton transporter activity"
+        } ]
+      }
     }, {
       "id" : "http://purl.obolibrary.org/obo/GO_0015081",
       "lbl" : "sodium ion transmembrane transporter activity",
@@ -24603,7 +24904,11 @@
       "meta" : {
         "definition" : {
           "val" : "Any constituent part of a virion, a complete fully infectious extracellular virus particle."
-        }
+        },
+        "synonyms" : [ {
+          "pred" : "hasExactSynonym",
+          "val" : "virion part"
+        } ]
       }
     }, {
       "id" : "http://purl.obolibrary.org/obo/GO_0044458",
@@ -29824,10 +30129,6 @@
           "val" : "upregulation of pigment cell differentiation"
         } ]
       }
-    }, {
-      "id" : "http://purl.obolibrary.org/obo/GO_0050952",
-      "lbl" : "sensory perception of electrical stimulus",
-      "type" : "CLASS"
     }, {
       "id" : "http://purl.obolibrary.org/obo/GO_0050953",
       "lbl" : "sensory perception of light stimulus",
@@ -29845,19 +30146,6 @@
           "val" : "perception of mechanical stimulus"
         } ]
       }
-    }, {
-      "id" : "http://purl.obolibrary.org/obo/GO_0050956",
-      "lbl" : "electroception",
-      "type" : "CLASS",
-      "meta" : {
-        "synonyms" : [ {
-          "pred" : "hasExactSynonym",
-          "val" : "electroception sense"
-        }, {
-          "pred" : "hasExactSynonym",
-          "val" : "electroceptive sense"
-        } ]
-      }
     }, {
       "id" : "http://purl.obolibrary.org/obo/GO_0050962",
       "lbl" : "detection of light stimulus involved in sensory perception",
@@ -29883,66 +30171,6 @@
           "val" : "sensory transduction of light stimulus during sensory perception"
         } ]
       }
-    }, {
-      "id" : "http://purl.obolibrary.org/obo/GO_0050963",
-      "lbl" : "detection of electrical stimulus involved in sensory perception",
-      "type" : "CLASS",
-      "meta" : {
-        "synonyms" : [ {
-          "pred" : "hasExactSynonym",
-          "val" : "sensory detection of electrical stimulus"
-        }, {
-          "pred" : "hasExactSynonym",
-          "val" : "sensory detection of electrical stimulus during sensory perception"
-        }, {
-          "pred" : "hasExactSynonym",
-          "val" : "sensory perception, sensory detection of electrical stimulus"
-        }, {
-          "pred" : "hasExactSynonym",
-          "val" : "sensory perception, sensory transduction of electrical stimulus"
-        }, {
-          "pred" : "hasExactSynonym",
-          "val" : "sensory transduction of electrical stimulus"
-        }, {
-          "pred" : "hasExactSynonym",
-          "val" : "sensory transduction of electrical stimulus during sensory perception"
-        } ]
-      }
-    }, {
-      "id" : "http://purl.obolibrary.org/obo/GO_0050964",
-      "lbl" : "detection of electrical stimulus involved in electroception",
-      "type" : "CLASS",
-      "meta" : {
-        "synonyms" : [ {
-          "pred" : "hasExactSynonym",
-          "val" : "electroception, detection of electrical stimulus"
-        }, {
-          "pred" : "hasExactSynonym",
-          "val" : "electroception, sensory detection of electrical stimulus"
-        }, {
-          "pred" : "hasExactSynonym",
-          "val" : "electroception, sensory transduction"
-        }, {
-          "pred" : "hasExactSynonym",
-          "val" : "electroception, sensory transduction of electrical stimulus"
-        } ]
-      }
-    }, {
-      "id" : "http://purl.obolibrary.org/obo/GO_0050967",
-      "lbl" : "detection of electrical stimulus involved in sensory perception of pain",
-      "type" : "CLASS",
-      "meta" : {
-        "synonyms" : [ {
-          "pred" : "hasExactSynonym",
-          "val" : "perception of pain, detection of electrical stimulus"
-        }, {
-          "pred" : "hasExactSynonym",
-          "val" : "perception of pain, sensory detection of electrical stimulus"
-        }, {
-          "pred" : "hasExactSynonym",
-          "val" : "perception of pain, sensory transduction of electrical stimulus"
-        } ]
-      }
     }, {
       "id" : "http://purl.obolibrary.org/obo/GO_0050968",
       "lbl" : "detection of chemical stimulus involved in sensory perception of pain",
@@ -29984,10 +30212,6 @@
           "val" : "tactition"
         } ]
       }
-    }, {
-      "id" : "http://purl.obolibrary.org/obo/GO_0050981",
-      "lbl" : "detection of electrical stimulus",
-      "type" : "CLASS"
     }, {
       "id" : "http://purl.obolibrary.org/obo/GO_0050994",
       "lbl" : "regulation of lipid catabolic process",
@@ -31051,10 +31275,6 @@
           "val" : "upregulation of neurotransmitter transport"
         } ]
       }
-    }, {
-      "id" : "http://purl.obolibrary.org/obo/GO_0051602",
-      "lbl" : "response to electrical stimulus",
-      "type" : "CLASS"
     }, {
       "id" : "http://purl.obolibrary.org/obo/GO_0051606",
       "lbl" : "detection of stimulus",
@@ -35960,6 +36180,16 @@
       "id" : "http://purl.obolibrary.org/obo/GO_0120025",
       "lbl" : "plasma membrane bounded cell projection",
       "type" : "CLASS"
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/GO_0120029",
+      "lbl" : "proton export across plasma membrane",
+      "type" : "CLASS",
+      "meta" : {
+        "synonyms" : [ {
+          "pred" : "hasExactSynonym",
+          "val" : "hydrogen ion export across plasma membrane"
+        } ]
+      }
     }, {
       "id" : "http://purl.obolibrary.org/obo/GO_0120031",
       "lbl" : "plasma membrane bounded cell projection assembly",
@@ -37574,6 +37804,19 @@
       "id" : "http://purl.obolibrary.org/obo/GO_1902570",
       "lbl" : "protein localization to nucleolus",
       "type" : "CLASS"
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/GO_1902600",
+      "lbl" : "proton transmembrane transport",
+      "type" : "CLASS",
+      "meta" : {
+        "synonyms" : [ {
+          "pred" : "hasExactSynonym",
+          "val" : "hydrogen ion transmembrane transport"
+        }, {
+          "pred" : "hasExactSynonym",
+          "val" : "hydrogen transmembrane transport"
+        } ]
+      }
     }, {
       "id" : "http://purl.obolibrary.org/obo/GO_1902679",
       "lbl" : "negative regulation of RNA biosynthetic process",
@@ -40666,6 +40909,14 @@
       "id" : "http://purl.obolibrary.org/obo/NCBITaxon_1206795",
       "lbl" : "Lophotrochozoa",
       "type" : "CLASS"
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/NCBITaxon_1224",
+      "lbl" : "Pseudomonadota",
+      "type" : "CLASS"
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/NCBITaxon_1236",
+      "lbl" : "Gammaproteobacteria",
+      "type" : "CLASS"
     }, {
       "id" : "http://purl.obolibrary.org/obo/NCBITaxon_124129",
       "lbl" : "Acipenserinae",
@@ -40840,9 +41091,6 @@
       "type" : "CLASS",
       "meta" : {
         "basicPropertyValues" : [ {
-          "pred" : "http://purl.obolibrary.org/obo/IAO_0000118",
-          "val" : "eucaryotes"
-        }, {
           "pred" : "http://purl.obolibrary.org/obo/IAO_0000118",
           "val" : "eukaryotes"
         } ]
@@ -40957,6 +41205,9 @@
       "type" : "CLASS",
       "meta" : {
         "basicPropertyValues" : [ {
+          "pred" : "http://purl.obolibrary.org/obo/IAO_0000118",
+          "val" : "animals"
+        }, {
           "pred" : "http://purl.obolibrary.org/obo/IAO_0000118",
           "val" : "metazoans"
         }, {
@@ -41004,6 +41255,10 @@
       "id" : "http://purl.obolibrary.org/obo/NCBITaxon_3378",
       "lbl" : "Gnetales",
       "type" : "CLASS"
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/NCBITaxon_3379134",
+      "lbl" : "Pseudomonadati",
+      "type" : "CLASS"
     }, {
       "id" : "http://purl.obolibrary.org/obo/NCBITaxon_3398",
       "lbl" : "Magnoliopsida",
@@ -41150,6 +41405,10 @@
       "id" : "http://purl.obolibrary.org/obo/NCBITaxon_50557",
       "lbl" : "Insecta",
       "type" : "CLASS"
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/NCBITaxon_543",
+      "lbl" : "Enterobacteriaceae",
+      "type" : "CLASS"
     }, {
       "id" : "http://purl.obolibrary.org/obo/NCBITaxon_554915",
       "lbl" : "Amoebozoa",
@@ -41162,6 +41421,14 @@
       "id" : "http://purl.obolibrary.org/obo/NCBITaxon_55885",
       "lbl" : "Peloderinae",
       "type" : "CLASS"
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/NCBITaxon_561",
+      "lbl" : "Escherichia",
+      "type" : "CLASS"
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/NCBITaxon_562",
+      "lbl" : "Escherichia coli",
+      "type" : "CLASS"
     }, {
       "id" : "http://purl.obolibrary.org/obo/NCBITaxon_5782",
       "lbl" : "Dictyostelium",
@@ -41222,6 +41489,10 @@
       "id" : "http://purl.obolibrary.org/obo/NCBITaxon_6362",
       "lbl" : "Sabellida",
       "type" : "CLASS"
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/NCBITaxon_637912",
+      "lbl" : "Escherichia coli OP50",
+      "type" : "CLASS"
     }, {
       "id" : "http://purl.obolibrary.org/obo/NCBITaxon_6656",
       "lbl" : "Arthropoda",
@@ -41443,6 +41714,10 @@
       "id" : "http://purl.obolibrary.org/obo/NCBITaxon_89593",
       "lbl" : "Craniata <chordates>",
       "type" : "CLASS"
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/NCBITaxon_91347",
+      "lbl" : "Enterobacterales",
+      "type" : "CLASS"
     }, {
       "id" : "http://purl.obolibrary.org/obo/NCBITaxon_9254",
       "lbl" : "Prototheria",
@@ -41527,10 +41802,22 @@
       "id" : "http://purl.obolibrary.org/obo/NCIT_C14376",
       "lbl" : "Other Organism Groupings",
       "type" : "CLASS"
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/NCIT_C16203",
+      "lbl" : "Clinical or Research Activity",
+      "type" : "CLASS"
     }, {
       "id" : "http://purl.obolibrary.org/obo/NCIT_C16847",
       "lbl" : "Technique",
       "type" : "CLASS"
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/NCIT_C16853",
+      "lbl" : "Microscopy",
+      "type" : "CLASS"
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/NCIT_C16856",
+      "lbl" : "Fluorescence Microscopy",
+      "type" : "CLASS"
     }, {
       "id" : "http://purl.obolibrary.org/obo/NCIT_C17187",
       "lbl" : "Technology",
@@ -41539,10 +41826,18 @@
       "id" : "http://purl.obolibrary.org/obo/NCIT_C172272",
       "lbl" : "Electronic File Content Type",
       "type" : "CLASS"
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/NCIT_C17369",
+      "lbl" : "Imaging Procedure",
+      "type" : "CLASS"
     }, {
       "id" : "http://purl.obolibrary.org/obo/NCIT_C179817",
       "lbl" : "Velocity",
       "type" : "CLASS"
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/NCIT_C17995",
+      "lbl" : "Light Microscopy",
+      "type" : "CLASS"
     }, {
       "id" : "http://purl.obolibrary.org/obo/NCIT_C18141",
       "lbl" : "Computer Sciences",
@@ -41599,6 +41894,10 @@
       "id" : "http://purl.obolibrary.org/obo/NCIT_C25206",
       "lbl" : "Temperature",
       "type" : "CLASS"
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/NCIT_C25218",
+      "lbl" : "Clinical Intervention or Procedure",
+      "type" : "CLASS"
     }, {
       "id" : "http://purl.obolibrary.org/obo/NCIT_C25284",
       "lbl" : "Type",
@@ -41607,6 +41906,10 @@
       "id" : "http://purl.obolibrary.org/obo/NCIT_C25285",
       "lbl" : "Diameter",
       "type" : "CLASS"
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/NCIT_C25294",
+      "lbl" : "Laboratory Procedure",
+      "type" : "CLASS"
     }, {
       "id" : "http://purl.obolibrary.org/obo/NCIT_C25335",
       "lbl" : "Volume",
@@ -41699,6 +42002,10 @@
       "id" : "http://purl.obolibrary.org/obo/NCIT_C73706",
       "lbl" : "Spatial Qualifier",
       "type" : "CLASS"
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/NCIT_C74957",
+      "lbl" : "Mixed Category Laboratory Procedure",
+      "type" : "CLASS"
     }, {
       "id" : "http://purl.obolibrary.org/obo/NCIT_C85776",
       "lbl" : "Optical Density Measurement",
@@ -44550,6 +44857,10 @@
       "id" : "http://purl.obolibrary.org/obo/UBERON_0000000",
       "lbl" : "processual entity",
       "type" : "CLASS"
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/UBERON_0000001",
+      "lbl" : "gross anatomical part",
+      "type" : "CLASS"
     }, {
       "id" : "http://purl.obolibrary.org/obo/UBERON_0000005",
       "lbl" : "chemosensory organ",
@@ -44765,6 +45076,9 @@
       "lbl" : "anatomical structure",
       "type" : "CLASS",
       "meta" : {
+        "definition" : {
+          "val" : "Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome."
+        },
         "synonyms" : [ {
           "pred" : "hasExactSynonym",
           "val" : "biological structure"
@@ -55591,19 +55905,6 @@
       "id" : "http://purl.obolibrary.org/obo/UBERON_0010499",
       "lbl" : "pseudostratified ciliated columnar epithelium",
       "type" : "CLASS"
-    }, {
-      "id" : "http://purl.obolibrary.org/obo/UBERON_0010521",
-      "lbl" : "electroreceptor organ",
-      "type" : "CLASS",
-      "meta" : {
-        "synonyms" : [ {
-          "pred" : "hasExactSynonym",
-          "val" : "electric sense organ"
-        }, {
-          "pred" : "hasExactSynonym",
-          "val" : "electroreception organ"
-        } ]
-      }
     }, {
       "id" : "http://purl.obolibrary.org/obo/UBERON_0010522",
       "lbl" : "replacement element",
@@ -58544,6 +58845,10 @@
           "val" : "rectal lamina propria"
         } ]
       }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/UBERON_8850001",
+      "lbl" : "epithelium of anorectum",
+      "type" : "CLASS"
     }, {
       "id" : "http://purl.obolibrary.org/obo/UO_0000001",
       "lbl" : "length unit",
@@ -58584,6 +58889,12 @@
       "id" : "http://purl.obolibrary.org/obo/UO_0000280",
       "lbl" : "rate unit",
       "type" : "CLASS"
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/format_1929",
+      "type" : "CLASS"
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/NCBITaxon:637912",
+      "type" : "CLASS"
     }, {
       "id" : "http://www.geneontology.org/formats/oboInOwl#ObsoleteClass",
       "lbl" : "Obsolete Class",
@@ -61132,6 +61443,89 @@
           "val" : "X device utilizes material Y means X and Y are material entities, and X is capable of some process P that has input Y."
         }
       }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/RO_0018030",
+      "lbl" : "chemical relationship",
+      "type" : "PROPERTY",
+      "propertyType" : "OBJECT"
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/RO_0018033",
+      "lbl" : "is deprotonated form of",
+      "type" : "PROPERTY",
+      "propertyType" : "OBJECT",
+      "meta" : {
+        "definition" : {
+          "val" : "A is a deprotonated form of B if and only if A is chemical entity that is a Brønsted–Lowry Base (i.e., can receive a proton) and by adding some nonzero number of protons transforms it into B.\n\nThis is a transitive relationship and follows this design pattern: https://oborel.github.io/obo-relations/direct-and-indirect-relations."
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/RO_0018034",
+      "lbl" : "is protonated form of",
+      "type" : "PROPERTY",
+      "propertyType" : "OBJECT",
+      "meta" : {
+        "definition" : {
+          "val" : "A is a protonated form of B if and only if A is chemical entity that is a Brønsted–Lowry Acid (i.e., can give up a proton) and by removing some nonzero number of protons transforms it into B.\n\nThis is a transitive relationship and follows this design pattern: https://oborel.github.io/obo-relations/direct-and-indirect-relations."
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/RO_0018036",
+      "lbl" : "is tautomer of",
+      "type" : "PROPERTY",
+      "propertyType" : "OBJECT",
+      "meta" : {
+        "definition" : {
+          "val" : "Two chemicals are tautomers if they can be readily interconverted.\n\nThis commonly refers to prototropy in which a hydrogen's position is changed, such as between ketones and enols. This is also often observed in heterocyclic rings, e.g., ones containing nitrogens and/or have aryl functional groups containing heteroatoms."
+        },
+        "synonyms" : [ {
+          "pred" : "hasExactSynonym",
+          "val" : "is desmotrope of"
+        } ]
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/RO_0018037",
+      "lbl" : "is substitutent group from",
+      "type" : "PROPERTY",
+      "propertyType" : "OBJECT",
+      "meta" : {
+        "definition" : {
+          "val" : "Group A is a substituent group from Chemical B if A represents the functional part of A and includes information about where it is connected. A is not itself a chemical with a fully formed chemical graph, but is rather a partial graph with one or more connection points that can be used to attach to another chemical graph, typically as a functionalization."
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/RO_0018038",
+      "lbl" : "has functional parent",
+      "type" : "PROPERTY",
+      "propertyType" : "OBJECT",
+      "meta" : {
+        "definition" : {
+          "val" : "Chemical A has functional parent Chemical B if there is chemical transformation through which chemical B can be produced from chemical A. \n\nFor example, the relationship between a salt and a freebased compound is a \"has functional parent\" relationship."
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/RO_0018039",
+      "lbl" : "is enantiomer of",
+      "type" : "PROPERTY",
+      "propertyType" : "OBJECT",
+      "meta" : {
+        "definition" : {
+          "val" : "Chemicals A and B are enantiomers if they share the same molecular graph except the change of the configuration of substituents around exactly one chiral center.\n\nA chemical with no chiral centers can not have an enantiomer. A chemical with multiple chiral centers can have multiple enantiomers, but its enantiomers are not themselves enantiomers (they are diastereomers)."
+        },
+        "synonyms" : [ {
+          "pred" : "hasExactSynonym",
+          "val" : "is optical isomer of"
+        } ]
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/RO_0018040",
+      "lbl" : "has parent hydride",
+      "type" : "PROPERTY",
+      "propertyType" : "OBJECT",
+      "meta" : {
+        "definition" : {
+          "val" : "Chemical A has parent hydride Chemical B if there exists a molecular graphical transformation where functional groups on A are replaced with hydrogens in order to yield B."
+        }
+      }
     }, {
       "id" : "http://purl.obolibrary.org/obo/RO_0019000",
       "lbl" : "regulates characteristic",
@@ -61232,10 +61626,6 @@
       "id" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of",
       "type" : "PROPERTY",
       "propertyType" : "OBJECT"
-    }, {
-      "id" : "http://purl.obolibrary.org/obo/chebi#is_enantiomer_of",
-      "type" : "PROPERTY",
-      "propertyType" : "OBJECT"
     }, {
       "id" : "http://purl.obolibrary.org/obo/chebi#is_substituent_group_from",
       "type" : "PROPERTY",
@@ -64469,7 +64859,7 @@
       "propertyType" : "ANNOTATION",
       "meta" : {
         "definition" : {
-          "val" : "The official definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions."
+          "val" : "The official definition."
         }
       }
     }, {
@@ -64592,6 +64982,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_132153",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_63551"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_132153",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_16336"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_132153",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of",
@@ -64624,6 +65018,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_13941",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_37022"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_13941",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_28616"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_13941",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of",
@@ -64634,7 +65032,7 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_26666"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_140601",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_78115"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_142163",
@@ -64654,12 +65052,12 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_78675"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_14321",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
-      "obj" : "http://purl.obolibrary.org/obo/CHEBI_29987"
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_18237"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_14321",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of",
-      "obj" : "http://purl.obolibrary.org/obo/CHEBI_18237"
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_29987"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_15339",
       "pred" : "is_a",
@@ -64716,10 +65114,30 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_15366",
       "pred" : "http://purl.obolibrary.org/obo/RO_0000087",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_83056"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_15366",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_30089"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_15366",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_30089"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_15378",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_25414"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_15378",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_33251"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_15378",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_33252"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_15378",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_60242"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_15379",
       "pred" : "is_a",
@@ -64760,6 +65178,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_15379",
       "pred" : "http://purl.obolibrary.org/obo/RO_0000087",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_77974"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_15379",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_29793"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_15379",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of",
@@ -64774,11 +65196,11 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_33704"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_15705",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_59814"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_15705",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_tautomer_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018036",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_59869"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_15841",
@@ -64802,11 +65224,11 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_76971"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_15966",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_29986"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_15966",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_enantiomer_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018039",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_16015"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_15986",
@@ -64854,11 +65276,11 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_76971"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_16015",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_29985"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_16015",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_enantiomer_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018039",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_15966"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_16134",
@@ -64896,6 +65318,14 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_16134",
       "pred" : "http://purl.obolibrary.org/obo/RO_0000087",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_78433"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_16134",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_28938"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_16134",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_29337"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_16134",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
@@ -64928,6 +65358,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_16189",
       "pred" : "http://purl.obolibrary.org/obo/RO_0000087",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_77746"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_16189",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_45696"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_16189",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of",
@@ -64944,6 +65378,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_16336",
       "pred" : "http://purl.obolibrary.org/obo/RO_0000087",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_77746"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_16336",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_132153"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_16336",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
@@ -64976,6 +65414,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_16670",
       "pred" : "http://purl.obolibrary.org/obo/BFO_0000051",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_33708"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_16670",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018036",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_60466"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_16670",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_tautomer_of",
@@ -64990,7 +65432,7 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_35274"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_166902",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_33569"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_16733",
@@ -64998,11 +65440,11 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_83925"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_16733",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_60895"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_16733",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_tautomer_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018036",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_59871"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_167559",
@@ -65036,6 +65478,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_16765",
       "pred" : "http://purl.obolibrary.org/obo/RO_0000087",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_77746"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_16765",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_57887"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_16765",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of",
@@ -65066,16 +65512,16 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_77746"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_16865",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#has_functional_parent",
-      "obj" : "http://purl.obolibrary.org/obo/CHEBI_30772"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/CHEBI_16865",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_30566"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_16865",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_tautomer_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018036",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_59888"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_16865",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018038",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_30772"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_16990",
       "pred" : "is_a",
@@ -65102,7 +65548,7 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_77746"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_16990",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_57977"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_17087",
@@ -65154,12 +65600,12 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_77746"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_17544",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
-      "obj" : "http://purl.obolibrary.org/obo/CHEBI_41609"
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_28976"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_17544",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of",
-      "obj" : "http://purl.obolibrary.org/obo/CHEBI_28976"
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_41609"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_17608",
       "pred" : "is_a",
@@ -65198,7 +65644,7 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_77746"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_17968",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_30772"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_18059",
@@ -65242,7 +65688,7 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_78675"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_18237",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_14321"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_18282",
@@ -65274,11 +65720,11 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_75771"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_18357",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_72587"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_18357",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_enantiomer_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018039",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_33571"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_20664",
@@ -65360,6 +65806,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_23004",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_27207"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_23004",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018037",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_28616"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_23004",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_substituent_group_from",
@@ -65376,6 +65826,18 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_23367",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_24431"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_234420",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_166902"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_234420",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_33571"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_234420",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018039",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_72587"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_23449",
       "pred" : "is_a",
@@ -65459,7 +65921,11 @@
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_24636",
       "pred" : "is_a",
-      "obj" : "http://purl.obolibrary.org/obo/CHEBI_36342"
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_15378"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_24636",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_33253"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_24636",
       "pred" : "is_a",
@@ -65490,7 +65956,7 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_36248"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_24663",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#has_functional_parent",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018038",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_36238"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_24828",
@@ -65532,10 +65998,6 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_24866",
       "pred" : "http://purl.obolibrary.org/obo/BFO_0000051",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_22563"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/CHEBI_24866",
-      "pred" : "http://purl.obolibrary.org/obo/BFO_0000051",
-      "obj" : "http://purl.obolibrary.org/obo/CHEBI_36916"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_24867",
       "pred" : "is_a",
@@ -65592,6 +66054,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_25384",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_33575"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_25384",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_35757"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_25384",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
@@ -65648,6 +66114,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_25704",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_26820"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_25704",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_58958"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_25704",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
@@ -65694,7 +66164,7 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_33709"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_26167",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_tautomer_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018036",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_62031"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_26607",
@@ -65706,7 +66176,7 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_35366"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_26666",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_58951"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_26708",
@@ -65788,6 +66258,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_26836",
       "pred" : "http://purl.obolibrary.org/obo/RO_0000087",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_35223"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_26836",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_45696"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_26836",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
@@ -65864,6 +66338,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_28616",
       "pred" : "http://purl.obolibrary.org/obo/RO_0000087",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_76971"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_28616",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_13941"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_28616",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
@@ -65900,6 +66378,14 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_28790",
       "pred" : "http://purl.obolibrary.org/obo/RO_0000087",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_77746"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_28790",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_350546"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_28790",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018038",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_16765"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_28790",
       "pred" : "http://purl.obolibrary.org/obo/chebi#has_functional_parent",
@@ -65918,7 +66404,7 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_35757"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_28868",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_35366"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_28938",
@@ -65948,6 +66434,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_28938",
       "pred" : "http://purl.obolibrary.org/obo/RO_0000087",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_77746"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_28938",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_16134"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_28938",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
@@ -65974,7 +66464,7 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_75771"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_28976",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_17544"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_29067",
@@ -65984,6 +66474,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_29067",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_35406"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_29067",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_33575"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_29067",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of",
@@ -66020,6 +66514,14 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_29337",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_79389"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_29337",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_16134"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_29337",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_29340"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_29337",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
@@ -66036,6 +66538,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_29340",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_79388"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_29340",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_29337"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_29340",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of",
@@ -66044,6 +66550,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_29793",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_33693"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_29793",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_15379"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_29793",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
@@ -66066,15 +66576,15 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_77746"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_29985",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
-      "obj" : "http://purl.obolibrary.org/obo/CHEBI_29988"
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_16015"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_29985",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of",
-      "obj" : "http://purl.obolibrary.org/obo/CHEBI_16015"
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_29988"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_29985",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_enantiomer_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018039",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_29986"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_29986",
@@ -66082,15 +66592,15 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_14321"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_29986",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
-      "obj" : "http://purl.obolibrary.org/obo/CHEBI_29989"
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_15966"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_29986",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of",
-      "obj" : "http://purl.obolibrary.org/obo/CHEBI_15966"
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_29989"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_29986",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_enantiomer_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018039",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_29985"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_29987",
@@ -66102,7 +66612,7 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_78675"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_29987",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_14321"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_29988",
@@ -66114,11 +66624,11 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_59814"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_29988",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_29985"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_29988",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_enantiomer_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018039",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_29989"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_29989",
@@ -66126,11 +66636,11 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_29987"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_29989",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_29986"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_29989",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_enantiomer_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018039",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_29988"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_30089",
@@ -66144,6 +66654,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_30089",
       "pred" : "http://purl.obolibrary.org/obo/RO_0000087",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_77746"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_30089",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_15366"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_30089",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of",
@@ -66162,12 +66676,12 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_77746"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_30566",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#has_functional_parent",
-      "obj" : "http://purl.obolibrary.org/obo/CHEBI_17968"
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_16865"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_30566",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of",
-      "obj" : "http://purl.obolibrary.org/obo/CHEBI_16865"
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018038",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_17968"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_30772",
       "pred" : "is_a",
@@ -66186,7 +66700,7 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_84087"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_30772",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_17968"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_3098",
@@ -66220,6 +66734,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_33241",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_37577"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_33241",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018038",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_24833"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_33241",
       "pred" : "http://purl.obolibrary.org/obo/chebi#has_functional_parent",
@@ -66248,6 +66766,14 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_33247",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_24433"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_33247",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_64769"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_33247",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_64775"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_33247",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
@@ -66264,14 +66790,18 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_33250",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_24431"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/CHEBI_33250",
-      "pred" : "http://purl.obolibrary.org/obo/BFO_0000051",
-      "obj" : "http://purl.obolibrary.org/obo/CHEBI_10545"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_33250",
       "pred" : "http://purl.obolibrary.org/obo/BFO_0000051",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_33252"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_33251",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_33238"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_33251",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_33260"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_33252",
       "pred" : "is_a",
@@ -66296,6 +66826,18 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_33259",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_23367"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_33260",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_24835"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_33260",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_33259"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_33260",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_33608"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_33262",
       "pred" : "is_a",
@@ -66432,6 +66974,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_33558",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_37022"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_33558",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_33704"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_33558",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of",
@@ -66466,7 +67012,7 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_76967"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_33569",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_166902"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_33570",
@@ -66478,7 +67024,11 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_33569"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_33571",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_enantiomer_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_234420"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_33571",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018039",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_18357"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_33575",
@@ -66496,6 +67046,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_33575",
       "pred" : "http://purl.obolibrary.org/obo/BFO_0000051",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_46883"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_33575",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_29067"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_33575",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
@@ -66524,10 +67078,6 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_33608",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_33674"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/CHEBI_33608",
-      "pred" : "http://purl.obolibrary.org/obo/BFO_0000051",
-      "obj" : "http://purl.obolibrary.org/obo/CHEBI_49637"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_33635",
       "pred" : "is_a",
@@ -66568,10 +67118,6 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_33674",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_33579"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/CHEBI_33674",
-      "pred" : "http://purl.obolibrary.org/obo/BFO_0000051",
-      "obj" : "http://purl.obolibrary.org/obo/CHEBI_33559"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_33675",
       "pred" : "is_a",
@@ -66648,6 +67194,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_33703",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_33702"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_33703",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_33709"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_33703",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
@@ -66656,6 +67206,18 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_33704",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_33709"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_33704",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_33719"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_33704",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_33558"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_33704",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018036",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_78608"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_33704",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
@@ -66674,12 +67236,24 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_83820"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_33707",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_71666"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_33708",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_33247"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_33708",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_58942"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_33708",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_64898"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_33708",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018037",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_33709"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_33708",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
@@ -66700,6 +67274,14 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_33709",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_50047"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_33709",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_33703"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_33709",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_37022"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_33709",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
@@ -66712,6 +67294,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_33710",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_33708"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_33710",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018037",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_33704"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_33710",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_substituent_group_from",
@@ -66720,6 +67306,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_33719",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_33703"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_33719",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_33704"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_33719",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
@@ -66732,6 +67322,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_33720",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_33575"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_33720",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_33721"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_33720",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
@@ -66740,6 +67334,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_33721",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_29067"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_33721",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_33720"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_33721",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of",
@@ -66824,6 +67422,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_350546",
       "pred" : "http://purl.obolibrary.org/obo/RO_0000087",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_77746"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_350546",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_28790"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_350546",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
@@ -66868,6 +67470,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_35274",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_51143"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_35274",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018040",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_28938"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_35274",
       "pred" : "http://purl.obolibrary.org/obo/chebi#has_parent_hydride",
@@ -66910,7 +67516,7 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_25384"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_35366",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_28868"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_35381",
@@ -67006,7 +67612,7 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_33575"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_35692",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_35693"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_35693",
@@ -67014,7 +67620,7 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_29067"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_35693",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_35692"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_35701",
@@ -67044,6 +67650,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_35757",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_29067"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_35757",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_25384"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_35757",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of",
@@ -67070,7 +67680,7 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_35341"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_36078",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#has_parent_hydride",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018040",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_35519"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_36080",
@@ -67122,7 +67732,7 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_36278"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_36248",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#has_parent_hydride",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018040",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_20664"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_36277",
@@ -67276,6 +67886,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_37022",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_35352"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_37022",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_33709"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_37022",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of",
@@ -67336,6 +67950,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_37826",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_33424"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_37826",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018038",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_26836"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_37826",
       "pred" : "http://purl.obolibrary.org/obo/chebi#has_functional_parent",
@@ -67344,6 +67962,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_37838",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_22221"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_37838",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018037",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_33575"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_37838",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_substituent_group_from",
@@ -67450,7 +68072,7 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_59202"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_39418",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_58954"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_41609",
@@ -67458,7 +68080,7 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_35604"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_41609",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_17544"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_4167",
@@ -67496,6 +68118,14 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_45696",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_33482"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_45696",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_26836"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_45696",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_16189"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_45696",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
@@ -67524,6 +68154,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_47622",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_33308"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_47622",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018038",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_15366"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_47622",
       "pred" : "http://purl.obolibrary.org/obo/chebi#has_functional_parent",
@@ -67538,7 +68172,7 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_64709"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_47891",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_50160"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_48154",
@@ -67592,6 +68226,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_50047",
       "pred" : "http://purl.obolibrary.org/obo/RO_0000087",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_39142"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_50047",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018040",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_16134"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_50047",
       "pred" : "http://purl.obolibrary.org/obo/chebi#has_parent_hydride",
@@ -67602,7 +68240,7 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_29067"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_50160",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_47891"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_50297",
@@ -67664,6 +68302,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_50994",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_50047"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_50994",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_65296"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_50994",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of",
@@ -67764,6 +68406,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_57887",
       "pred" : "http://purl.obolibrary.org/obo/RO_0000087",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_77746"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_57887",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_16765"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_57887",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
@@ -67782,12 +68428,16 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_77746"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_57977",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_16990"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_58942",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_64769"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_58942",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_33708"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_58942",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
@@ -67798,7 +68448,7 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_28868"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_58951",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_26666"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_58953",
@@ -67810,7 +68460,7 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_58953"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_58954",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_39418"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_58958",
@@ -67820,6 +68470,14 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_58958",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_33482"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_58958",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_25704"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_58958",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018038",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_16189"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_58958",
       "pred" : "http://purl.obolibrary.org/obo/chebi#has_functional_parent",
@@ -67834,7 +68492,7 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_35366"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_59202",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_59203"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_59203",
@@ -67842,7 +68500,7 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_28868"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_59203",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_59202"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_59252",
@@ -67862,7 +68520,7 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_33558"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_59814",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_15705"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_59869",
@@ -67870,7 +68528,7 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_78608"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_59869",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_tautomer_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018036",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_15705"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_59871",
@@ -67878,7 +68536,7 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_35238"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_59871",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_tautomer_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018036",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_16733"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_59888",
@@ -67886,7 +68544,7 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_35238"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_59888",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_tautomer_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018036",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_16865"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_59999",
@@ -67920,6 +68578,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_60466",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_27369"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_60466",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018036",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_16670"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_60466",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_tautomer_of",
@@ -67930,7 +68592,7 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_33558"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_60895",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_16733"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_61115",
@@ -67944,6 +68606,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_61120",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_51143"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_61120",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018038",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_18282"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_61120",
       "pred" : "http://purl.obolibrary.org/obo/chebi#has_functional_parent",
@@ -67962,7 +68628,7 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_35238"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_62031",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_tautomer_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018036",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_26167"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_62488",
@@ -67976,6 +68642,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_63299",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_78616"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_63299",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018038",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_16646"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_63299",
       "pred" : "http://purl.obolibrary.org/obo/chebi#has_functional_parent",
@@ -67984,6 +68654,14 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_63436",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_63299"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_63436",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_63551"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_63436",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018038",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_33720"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_63436",
       "pred" : "http://purl.obolibrary.org/obo/chebi#has_functional_parent",
@@ -68000,6 +68678,14 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_63551",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_29067"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_63551",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_63436"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_63551",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018038",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_33721"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_63551",
       "pred" : "http://purl.obolibrary.org/obo/chebi#has_functional_parent",
@@ -68052,6 +68738,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_64769",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_64766"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_64769",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_33247"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_64769",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
@@ -68060,6 +68750,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_64775",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_64767"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_64775",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_33247"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_64775",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of",
@@ -68068,6 +68762,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_64898",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_64775"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_64898",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_33708"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_64898",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of",
@@ -68088,6 +68786,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_65212",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_63299"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_65212",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018038",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_18154"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_65212",
       "pred" : "http://purl.obolibrary.org/obo/chebi#has_functional_parent",
@@ -68112,6 +68814,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_65296",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_35274"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_65296",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_50994"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_65296",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
@@ -68126,7 +68832,7 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_37022"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_71666",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_33707"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_72587",
@@ -68138,8 +68844,12 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_77746"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_72587",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_18357"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_72587",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018039",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_234420"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_72695",
       "pred" : "is_a",
@@ -68258,7 +68968,7 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_58953"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_78115",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_140601"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_78295",
@@ -68272,6 +68982,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_78608",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_35238"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_78608",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018036",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_33704"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_78608",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_tautomer_of",
@@ -69120,6 +69834,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CL_0000138",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CL_0000667"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CL_0000138",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/CL_0007001"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CL_0000138",
       "pred" : "http://purl.obolibrary.org/obo/RO_0001025",
@@ -76264,6 +76982,118 @@
       "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000230",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/NCIT_C172272"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000231",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000101"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000232",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000231"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000233",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000231"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000234",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000231"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000235",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000100"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000236",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000235"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000237",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000235"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000238",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000076"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000239",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000238"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000240",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000239"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000241",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000239"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000242",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000239"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000243",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000239"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000244",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000239"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000245",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000239"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000246",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000239"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000247",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000001"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000248",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000247"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000249",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000247"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000250",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000080"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000251",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000250"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000252",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000250"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000253",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/format_1929"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000254",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_637912"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000255",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000189"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000256",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000189"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000257",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000129"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000258",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/NCIT_C16856"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/GO_0000011",
       "pred" : "is_a",
@@ -82856,6 +83686,10 @@
       "sub" : "http://purl.obolibrary.org/obo/GO_0008150",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/BFO_0000015"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/GO_0008150",
+      "pred" : "http://purl.obolibrary.org/obo/BFO_0000051",
+      "obj" : "http://purl.obolibrary.org/obo/GO_0003674"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/GO_0008152",
       "pred" : "is_a",
@@ -83832,6 +84666,14 @@
       "sub" : "http://purl.obolibrary.org/obo/GO_0010070",
       "pred" : "http://purl.obolibrary.org/obo/RO_0004009",
       "obj" : "http://purl.obolibrary.org/obo/CL_0000365"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/GO_0010155",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/GO_1904062"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/GO_0010155",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0002211",
+      "obj" : "http://purl.obolibrary.org/obo/GO_1902600"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/GO_0010160",
       "pred" : "is_a",
@@ -85952,22 +86794,6 @@
       "sub" : "http://purl.obolibrary.org/obo/GO_0014874",
       "pred" : "http://purl.obolibrary.org/obo/BFO_0000050",
       "obj" : "http://purl.obolibrary.org/obo/GO_0043502"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/GO_0014878",
-      "pred" : "is_a",
-      "obj" : "http://purl.obolibrary.org/obo/GO_0014874"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/GO_0014878",
-      "pred" : "is_a",
-      "obj" : "http://purl.obolibrary.org/obo/GO_0051602"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/GO_0014879",
-      "pred" : "is_a",
-      "obj" : "http://purl.obolibrary.org/obo/GO_0014878"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/GO_0014879",
-      "pred" : "is_a",
-      "obj" : "http://purl.obolibrary.org/obo/GO_0050981"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/GO_0014887",
       "pred" : "is_a",
@@ -86088,6 +86914,18 @@
       "sub" : "http://purl.obolibrary.org/obo/GO_0015075",
       "pred" : "http://purl.obolibrary.org/obo/RO_0004009",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_24867"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/GO_0015078",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/GO_0008324"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/GO_0015078",
+      "pred" : "http://purl.obolibrary.org/obo/BFO_0000050",
+      "obj" : "http://purl.obolibrary.org/obo/GO_1902600"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/GO_0015078",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0004009",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_15378"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/GO_0015081",
       "pred" : "is_a",
@@ -100716,10 +101554,6 @@
       "sub" : "http://purl.obolibrary.org/obo/GO_0050942",
       "pred" : "http://purl.obolibrary.org/obo/RO_0002213",
       "obj" : "http://purl.obolibrary.org/obo/GO_0050931"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/GO_0050952",
-      "pred" : "is_a",
-      "obj" : "http://purl.obolibrary.org/obo/GO_0007600"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/GO_0050953",
       "pred" : "is_a",
@@ -100728,10 +101562,6 @@
       "sub" : "http://purl.obolibrary.org/obo/GO_0050954",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/GO_0007600"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/GO_0050956",
-      "pred" : "is_a",
-      "obj" : "http://purl.obolibrary.org/obo/GO_0050952"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/GO_0050962",
       "pred" : "is_a",
@@ -100744,34 +101574,6 @@
       "sub" : "http://purl.obolibrary.org/obo/GO_0050962",
       "pred" : "http://purl.obolibrary.org/obo/BFO_0000050",
       "obj" : "http://purl.obolibrary.org/obo/GO_0050953"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/GO_0050963",
-      "pred" : "is_a",
-      "obj" : "http://purl.obolibrary.org/obo/GO_0050906"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/GO_0050963",
-      "pred" : "is_a",
-      "obj" : "http://purl.obolibrary.org/obo/GO_0050981"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/GO_0050963",
-      "pred" : "http://purl.obolibrary.org/obo/BFO_0000050",
-      "obj" : "http://purl.obolibrary.org/obo/GO_0050952"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/GO_0050964",
-      "pred" : "is_a",
-      "obj" : "http://purl.obolibrary.org/obo/GO_0050963"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/GO_0050964",
-      "pred" : "http://purl.obolibrary.org/obo/BFO_0000050",
-      "obj" : "http://purl.obolibrary.org/obo/GO_0050956"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/GO_0050967",
-      "pred" : "is_a",
-      "obj" : "http://purl.obolibrary.org/obo/GO_0050963"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/GO_0050967",
-      "pred" : "is_a",
-      "obj" : "http://purl.obolibrary.org/obo/GO_0062149"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/GO_0050968",
       "pred" : "is_a",
@@ -100784,14 +101586,6 @@
       "sub" : "http://purl.obolibrary.org/obo/GO_0050975",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/GO_0050954"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/GO_0050981",
-      "pred" : "is_a",
-      "obj" : "http://purl.obolibrary.org/obo/GO_0009582"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/GO_0050981",
-      "pred" : "is_a",
-      "obj" : "http://purl.obolibrary.org/obo/GO_0051602"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/GO_0050994",
       "pred" : "is_a",
@@ -101696,10 +102490,6 @@
       "sub" : "http://purl.obolibrary.org/obo/GO_0051590",
       "pred" : "http://purl.obolibrary.org/obo/RO_0002213",
       "obj" : "http://purl.obolibrary.org/obo/GO_0006836"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/GO_0051602",
-      "pred" : "is_a",
-      "obj" : "http://purl.obolibrary.org/obo/GO_0009628"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/GO_0051606",
       "pred" : "is_a",
@@ -110756,6 +111546,14 @@
       "sub" : "http://purl.obolibrary.org/obo/GO_0120025",
       "pred" : "http://purl.obolibrary.org/obo/BFO_0000051",
       "obj" : "http://purl.obolibrary.org/obo/GO_0098590"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/GO_0120029",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/GO_0140115"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/GO_0120029",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/GO_1902600"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/GO_0120031",
       "pred" : "is_a",
@@ -114088,6 +114886,18 @@
       "sub" : "http://purl.obolibrary.org/obo/GO_1902570",
       "pred" : "http://purl.obolibrary.org/obo/RO_0002339",
       "obj" : "http://purl.obolibrary.org/obo/GO_0005730"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/GO_1902600",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/GO_0098655"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/GO_1902600",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/GO_0098662"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/GO_1902600",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0004009",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_15378"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/GO_1902679",
       "pred" : "is_a",
@@ -121504,6 +122314,14 @@
       "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_1206795",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_2697495"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_1224",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_3379134"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_1236",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_1224"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_124129",
       "pred" : "is_a",
@@ -121524,6 +122342,10 @@
       "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_1312402",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33213"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_131567",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/COB_0000022"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_131567",
       "pred" : "is_a",
@@ -121672,10 +122494,6 @@
       "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_2743711",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_2743709"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_2759",
-      "pred" : "is_a",
-      "obj" : "http://purl.obolibrary.org/obo/COB_0000022"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_2759",
       "pred" : "is_a",
@@ -121816,6 +122634,10 @@
       "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_3378",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_1445966"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_3379134",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_2"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_3398",
       "pred" : "is_a",
@@ -121956,6 +122778,10 @@
       "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_50557",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6960"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_543",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_91347"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_554915",
       "pred" : "is_a",
@@ -121968,6 +122794,14 @@
       "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_55885",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6243"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_561",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_543"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_562",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_561"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_5782",
       "pred" : "is_a",
@@ -122028,6 +122862,10 @@
       "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_6362",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_105391"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_637912",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_562"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_6656",
       "pred" : "is_a",
@@ -122240,6 +123078,10 @@
       "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_89593",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7711"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_91347",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_1236"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_9254",
       "pred" : "is_a",
@@ -122308,10 +123150,26 @@
       "sub" : "http://purl.obolibrary.org/obo/NCIT_C14376",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/NCIT_C14250"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/NCIT_C16203",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/NCIT_C43431"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/NCIT_C16847",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/NCIT_C43431"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/NCIT_C16853",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/NCIT_C17369"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/NCIT_C16853",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/NCIT_C74957"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/NCIT_C16856",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/NCIT_C17995"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/NCIT_C17187",
       "pred" : "is_a",
@@ -122320,6 +123178,10 @@
       "sub" : "http://purl.obolibrary.org/obo/NCIT_C172272",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/NCIT_C25284"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/NCIT_C17369",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/NCIT_C25218"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/NCIT_C179817",
       "pred" : "is_a",
@@ -122328,6 +123190,10 @@
       "sub" : "http://purl.obolibrary.org/obo/NCIT_C179817",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/NCIT_C70766"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/NCIT_C17995",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/NCIT_C16853"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/NCIT_C18141",
       "pred" : "is_a",
@@ -122380,6 +123246,10 @@
       "sub" : "http://purl.obolibrary.org/obo/NCIT_C25206",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/NCIT_C25447"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/NCIT_C25218",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/NCIT_C16203"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/NCIT_C25284",
       "pred" : "is_a",
@@ -122388,6 +123258,10 @@
       "sub" : "http://purl.obolibrary.org/obo/NCIT_C25285",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/NCIT_C70766"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/NCIT_C25294",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/NCIT_C25218"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/NCIT_C25335",
       "pred" : "is_a",
@@ -122480,6 +123354,10 @@
       "sub" : "http://purl.obolibrary.org/obo/NCIT_C73706",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/NCIT_C41009"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/NCIT_C74957",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/NCIT_C25294"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/NCIT_C85776",
       "pred" : "is_a",
@@ -124485,9 +125363,9 @@
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/BFO_0000040"
     }, {
-      "sub" : "http://purl.obolibrary.org/obo/UBERON_0000000",
+      "sub" : "http://purl.obolibrary.org/obo/UBERON_0000001",
       "pred" : "is_a",
-      "obj" : "http://purl.obolibrary.org/obo/BFO_0000003"
+      "obj" : "http://purl.obolibrary.org/obo/UBERON_0000465"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/UBERON_0000005",
       "pred" : "is_a",
@@ -125240,6 +126118,10 @@
       "sub" : "http://purl.obolibrary.org/obo/UBERON_0000102",
       "pred" : "http://purl.obolibrary.org/obo/BFO_0000050",
       "obj" : "http://purl.obolibrary.org/obo/UBERON_0002048"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/UBERON_0000104",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/BFO_0000015"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/UBERON_0000104",
       "pred" : "is_a",
@@ -125248,6 +126130,10 @@
       "sub" : "http://purl.obolibrary.org/obo/UBERON_0000104",
       "pred" : "http://purl.obolibrary.org/obo/RO_0002230",
       "obj" : "http://purl.obolibrary.org/obo/UBERON_0000071"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/UBERON_0000105",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/BFO_0000015"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/UBERON_0000105",
       "pred" : "is_a",
@@ -125600,10 +126486,6 @@
       "sub" : "http://purl.obolibrary.org/obo/UBERON_0000168",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/UBERON_0004921"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/UBERON_0000168",
-      "pred" : "http://purl.obolibrary.org/obo/BFO_0000050",
-      "obj" : "http://purl.obolibrary.org/obo/UBERON_0001155"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/UBERON_0000168",
       "pred" : "http://purl.obolibrary.org/obo/uberon/core#subdivision_of",
@@ -126147,7 +127029,7 @@
     }, {
       "sub" : "http://purl.obolibrary.org/obo/UBERON_0000463",
       "pred" : "is_a",
-      "obj" : "http://purl.obolibrary.org/obo/UBERON_0000465"
+      "obj" : "http://purl.obolibrary.org/obo/UBERON_0000001"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/UBERON_0000463",
       "pred" : "http://purl.obolibrary.org/obo/BFO_0000050",
@@ -126220,6 +127102,10 @@
       "sub" : "http://purl.obolibrary.org/obo/UBERON_0000475",
       "pred" : "http://purl.obolibrary.org/obo/BFO_0000050",
       "obj" : "http://purl.obolibrary.org/obo/UBERON_0000468"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/UBERON_0000476",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/UBERON_0000001"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/UBERON_0000476",
       "pred" : "is_a",
@@ -139264,10 +140150,6 @@
       "sub" : "http://purl.obolibrary.org/obo/UBERON_0004921",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/UBERON_0013522"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/UBERON_0004921",
-      "pred" : "http://purl.obolibrary.org/obo/BFO_0000050",
-      "obj" : "http://purl.obolibrary.org/obo/UBERON_0001555"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/UBERON_0004921",
       "pred" : "http://purl.obolibrary.org/obo/uberon/core#subdivision_of",
@@ -140151,7 +141033,7 @@
     }, {
       "sub" : "http://purl.obolibrary.org/obo/UBERON_0005423",
       "pred" : "is_a",
-      "obj" : "http://purl.obolibrary.org/obo/UBERON_0000465"
+      "obj" : "http://purl.obolibrary.org/obo/UBERON_0000001"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/UBERON_0005423",
       "pred" : "http://purl.obolibrary.org/obo/RO_0002215",
@@ -141260,10 +142142,6 @@
       "sub" : "http://purl.obolibrary.org/obo/UBERON_0006076",
       "pred" : "http://purl.obolibrary.org/obo/BFO_0000050",
       "obj" : "http://purl.obolibrary.org/obo/UBERON_0002090"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/UBERON_0006076",
-      "pred" : "http://purl.obolibrary.org/obo/BFO_0000050",
-      "obj" : "http://purl.obolibrary.org/obo/UBERON_0006071"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/UBERON_0006076",
       "pred" : "http://purl.obolibrary.org/obo/uberon/core#subdivision_of",
@@ -141272,10 +142150,6 @@
       "sub" : "http://purl.obolibrary.org/obo/UBERON_0006077",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/UBERON_0000075"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/UBERON_0006077",
-      "pred" : "http://purl.obolibrary.org/obo/BFO_0000050",
-      "obj" : "http://purl.obolibrary.org/obo/UBERON_0001130"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/UBERON_0006077",
       "pred" : "http://purl.obolibrary.org/obo/BFO_0000050",
@@ -144336,10 +145210,6 @@
       "sub" : "http://purl.obolibrary.org/obo/UBERON_0009568",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/UBERON_0006077"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/UBERON_0009568",
-      "pred" : "http://purl.obolibrary.org/obo/BFO_0000050",
-      "obj" : "http://purl.obolibrary.org/obo/UBERON_0002100"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/UBERON_0009568",
       "pred" : "http://purl.obolibrary.org/obo/uberon/core#subdivision_of",
@@ -146140,14 +147010,6 @@
       "sub" : "http://purl.obolibrary.org/obo/UBERON_0010499",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/UBERON_0010498"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/UBERON_0010521",
-      "pred" : "is_a",
-      "obj" : "http://purl.obolibrary.org/obo/UBERON_0000020"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/UBERON_0010521",
-      "pred" : "http://purl.obolibrary.org/obo/RO_0002215",
-      "obj" : "http://purl.obolibrary.org/obo/GO_0050964"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/UBERON_0010522",
       "pred" : "is_a",
@@ -147916,10 +148778,6 @@
       "sub" : "http://purl.obolibrary.org/obo/UBERON_0013522",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/UBERON_0000064"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/UBERON_0013522",
-      "pred" : "http://purl.obolibrary.org/obo/BFO_0000050",
-      "obj" : "http://purl.obolibrary.org/obo/UBERON_0000025"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/UBERON_0013522",
       "pred" : "http://purl.obolibrary.org/obo/BFO_0000051",
@@ -150495,7 +151353,7 @@
     }, {
       "sub" : "http://purl.obolibrary.org/obo/UBERON_0036215",
       "pred" : "is_a",
-      "obj" : "http://purl.obolibrary.org/obo/UBERON_0000465"
+      "obj" : "http://purl.obolibrary.org/obo/UBERON_0000001"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/UBERON_0036215",
       "pred" : "http://purl.obolibrary.org/obo/RO_0002007",
@@ -151388,6 +152246,14 @@
       "sub" : "http://purl.obolibrary.org/obo/UBERON_8600140",
       "pred" : "http://purl.obolibrary.org/obo/BFO_0000050",
       "obj" : "http://purl.obolibrary.org/obo/UBERON_0001052"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/UBERON_8850001",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/UBERON_0001278"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/UBERON_8850001",
+      "pred" : "http://purl.obolibrary.org/obo/BFO_0000050",
+      "obj" : "http://purl.obolibrary.org/obo/UBERON_8410050"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/UO_0000001",
       "pred" : "is_a",
@@ -154112,6 +154978,34 @@
       "sub" : "http://purl.obolibrary.org/obo/RO_0015016",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0002104"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/RO_0018033",
+      "pred" : "subPropertyOf",
+      "obj" : "http://purl.obolibrary.org/obo/RO_0018030"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/RO_0018034",
+      "pred" : "subPropertyOf",
+      "obj" : "http://purl.obolibrary.org/obo/RO_0018030"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/RO_0018036",
+      "pred" : "subPropertyOf",
+      "obj" : "http://purl.obolibrary.org/obo/RO_0018030"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/RO_0018037",
+      "pred" : "subPropertyOf",
+      "obj" : "http://purl.obolibrary.org/obo/RO_0018030"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/RO_0018038",
+      "pred" : "subPropertyOf",
+      "obj" : "http://purl.obolibrary.org/obo/RO_0018030"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/RO_0018039",
+      "pred" : "subPropertyOf",
+      "obj" : "http://purl.obolibrary.org/obo/RO_0018030"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/RO_0018040",
+      "pred" : "subPropertyOf",
+      "obj" : "http://purl.obolibrary.org/obo/RO_0018030"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0019000",
       "pred" : "subPropertyOf",
@@ -154188,6 +155082,10 @@
       "sub" : "http://purl.obolibrary.org/obo/uberon/core#proximally_connected_to",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/uberon/core#transitively_proximally_connected_to"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/uberon/core#subdivision_of",
+      "pred" : "subPropertyOf",
+      "obj" : "http://purl.obolibrary.org/obo/BFO_0000050"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/BFO_0000050",
       "pred" : "inverseOf",
@@ -154400,6 +155298,10 @@
       "sub" : "http://purl.obolibrary.org/obo/RO_0003000",
       "pred" : "inverseOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0003001"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/RO_0018033",
+      "pred" : "inverseOf",
+      "obj" : "http://purl.obolibrary.org/obo/RO_0018034"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/uberon/core#distally_connected_to",
       "pred" : "inverseOf",
@@ -162425,6 +163327,13 @@
         "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009",
         "fillerId" : "http://purl.obolibrary.org/obo/CL_0000365"
       } ]
+    }, {
+      "definedClassId" : "http://purl.obolibrary.org/obo/GO_0010155",
+      "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ],
+      "restrictions" : [ {
+        "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211",
+        "fillerId" : "http://purl.obolibrary.org/obo/GO_1902600"
+      } ]
     }, {
       "definedClassId" : "http://purl.obolibrary.org/obo/GO_0010160",
       "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048859" ],
@@ -163670,20 +164579,6 @@
         "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050",
         "fillerId" : "http://purl.obolibrary.org/obo/GO_0043502"
       } ]
-    }, {
-      "definedClassId" : "http://purl.obolibrary.org/obo/GO_0014878",
-      "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0051602" ],
-      "restrictions" : [ {
-        "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050",
-        "fillerId" : "http://purl.obolibrary.org/obo/GO_0043502"
-      } ]
-    }, {
-      "definedClassId" : "http://purl.obolibrary.org/obo/GO_0014879",
-      "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0050981" ],
-      "restrictions" : [ {
-        "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050",
-        "fillerId" : "http://purl.obolibrary.org/obo/GO_0043502"
-      } ]
     }, {
       "definedClassId" : "http://purl.obolibrary.org/obo/GO_0014887",
       "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0043500" ],
@@ -163768,6 +164663,16 @@
         "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009",
         "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_24867"
       } ]
+    }, {
+      "definedClassId" : "http://purl.obolibrary.org/obo/GO_0015078",
+      "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0005215" ],
+      "restrictions" : [ {
+        "propertyId" : "http://purl.obolibrary.org/obo/RO_0002342",
+        "fillerId" : "http://purl.obolibrary.org/obo/GO_0016020"
+      }, {
+        "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009",
+        "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_15378"
+      } ]
     }, {
       "definedClassId" : "http://purl.obolibrary.org/obo/GO_0015081",
       "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0022857" ],
@@ -171991,27 +172896,6 @@
         "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050",
         "fillerId" : "http://purl.obolibrary.org/obo/GO_0007600"
       } ]
-    }, {
-      "definedClassId" : "http://purl.obolibrary.org/obo/GO_0050963",
-      "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0050981" ],
-      "restrictions" : [ {
-        "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050",
-        "fillerId" : "http://purl.obolibrary.org/obo/GO_0007600"
-      } ]
-    }, {
-      "definedClassId" : "http://purl.obolibrary.org/obo/GO_0050964",
-      "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0050981" ],
-      "restrictions" : [ {
-        "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050",
-        "fillerId" : "http://purl.obolibrary.org/obo/GO_0050956"
-      } ]
-    }, {
-      "definedClassId" : "http://purl.obolibrary.org/obo/GO_0050967",
-      "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0050981" ],
-      "restrictions" : [ {
-        "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050",
-        "fillerId" : "http://purl.obolibrary.org/obo/GO_0019233"
-      } ]
     }, {
       "definedClassId" : "http://purl.obolibrary.org/obo/GO_0050968",
       "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009593" ],
@@ -178465,6 +179349,22 @@
         "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000051",
         "fillerId" : "http://purl.obolibrary.org/obo/GO_0098590"
       } ]
+    }, {
+      "definedClassId" : "http://purl.obolibrary.org/obo/GO_0120029",
+      "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006810" ],
+      "restrictions" : [ {
+        "propertyId" : "http://purl.obolibrary.org/obo/RO_0002338",
+        "fillerId" : "http://purl.obolibrary.org/obo/GO_0005829"
+      }, {
+        "propertyId" : "http://purl.obolibrary.org/obo/RO_0002339",
+        "fillerId" : "http://purl.obolibrary.org/obo/GO_0005576"
+      }, {
+        "propertyId" : "http://purl.obolibrary.org/obo/RO_0002342",
+        "fillerId" : "http://purl.obolibrary.org/obo/GO_0005886"
+      }, {
+        "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009",
+        "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_15378"
+      } ]
     }, {
       "definedClassId" : "http://purl.obolibrary.org/obo/GO_0120031",
       "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0022607" ],
@@ -180600,6 +181500,13 @@
         "propertyId" : "http://purl.obolibrary.org/obo/RO_0002339",
         "fillerId" : "http://purl.obolibrary.org/obo/GO_0005730"
       } ]
+    }, {
+      "definedClassId" : "http://purl.obolibrary.org/obo/GO_1902600",
+      "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0055085" ],
+      "restrictions" : [ {
+        "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009",
+        "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_15378"
+      } ]
     }, {
       "definedClassId" : "http://purl.obolibrary.org/obo/GO_1902679",
       "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ],
@@ -193813,13 +194720,6 @@
         "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000051",
         "fillerId" : "http://purl.obolibrary.org/obo/CL_0000067"
       } ]
-    }, {
-      "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0010521",
-      "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000062" ],
-      "restrictions" : [ {
-        "propertyId" : "http://purl.obolibrary.org/obo/RO_0002215",
-        "fillerId" : "http://purl.obolibrary.org/obo/GO_0050964"
-      } ]
     }, {
       "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0010527",
       "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002558" ],
@@ -196782,6 +197682,13 @@
         "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050",
         "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001052"
       } ]
+    }, {
+      "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_8850001",
+      "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000483" ],
+      "restrictions" : [ {
+        "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050",
+        "fillerId" : "http://purl.obolibrary.org/obo/UBERON_8410050"
+      } ]
     } ],
     "domainRangeAxioms" : [ {
       "predicateId" : "http://purl.obolibrary.org/obo/BFO_0000050",
diff --git a/empty-full.obo b/empty-full.obo
index aa703fb..3b9ca13 100644
--- a/empty-full.obo
+++ b/empty-full.obo
@@ -1,5 +1,5 @@
 format-version: 1.2
-data-version: empty/releases/2026-02-23/empty-full.owl
+data-version: empty/releases/2026-04-04/empty-full.owl
 idspace: dce http://purl.org/dc/elements/1.1/ 
 idspace: dcterms http://purl.org/dc/terms/ 
 idspace: oboInOwl http://www.geneontology.org/formats/oboInOwl# 
@@ -10,7 +10,7 @@ ontology: empty/empty-full
 property_value: dcterms:description "An ontology of experimental measurements in the sciences, the purposes for which experimental measurements were made, and experimental treatments, with a focus on life sciences." xsd:string
 property_value: dcterms:license https://creativecommons.org/licenses/by/4.0/
 property_value: dcterms:title "Experimental Measurements Purposes and Treatments ontologY" xsd:string
-property_value: owl:versionInfo "2026-02-23" xsd:string
+property_value: owl:versionInfo "2026-04-04" xsd:string
 property_value: owl:versionInfo "Release 2025-07-10" xsd:string
 
 [Term]
@@ -115,7 +115,7 @@ is_a: CHEBI:36338 ! lepton
 [Term]
 id: CHEBI:131604
 name: Mycoplasma genitalium metabolite
-def: "Any bacterial metabolite produced during a metabolic reaction in Mycoplasma genitalium." []
+def: "Any bacterial metabolite produced during a metabolic reaction in <em>Mycoplasma genitalium</em>." []
 is_a: CHEBI:76969 ! bacterial metabolite
 
 [Term]
@@ -131,11 +131,12 @@ def: "A carbohydrate acid derivative anion obtained by deprotonation of the carb
 is_a: CHEBI:61469 ! polyanionic polymer
 is_a: CHEBI:63551 ! carbohydrate acid derivative anion
 relationship: is_conjugate_base_of CHEBI:16336 ! hyaluronic acid
+relationship: RO:0018033 CHEBI:16336 ! is deprotonated form of hyaluronic acid
 
 [Term]
 id: CHEBI:136889
 name: 5beta steroid
-def: "Any steroid that has beta-configuration at position 5." []
+def: "Any steroid that has β-configuration at position 5." []
 is_a: CHEBI:35341 ! steroid
 
 [Term]
@@ -147,7 +148,7 @@ is_a: CHEBI:39141 ! Bronsted acid
 [Term]
 id: CHEBI:138366
 name: bile acids
-def: "Any member of a group of hydroxy steroids occuring in bile, where they are present as the sodium salts of their amides with glycine or taurine. In mammals bile acids almost invariably have 5beta-configuration, while in lower vertebrates, some bile acids, known as allo-bile acids, have 5alpha-configuration." []
+def: "Any member of a group of hydroxy steroids occuring in bile, where they are present as the sodium salts of their amides with glycine or taurine. In mammals bile acids almost invariably have 5β-configuration, while in lower vertebrates, some bile acids, known as <i>allo</i>-bile acids, have 5α-configuration." []
 is_a: CHEBI:25384 ! monocarboxylic acid
 is_a: CHEBI:35350 ! hydroxy steroid
 is_a: CHEBI:36078 ! cholanoid
@@ -163,29 +164,30 @@ id: CHEBI:13941
 name: carbamate
 is_a: CHEBI:37022 ! amino-acid anion
 relationship: is_conjugate_base_of CHEBI:28616 ! carbamic acid
+relationship: RO:0018033 CHEBI:28616 ! is deprotonated form of carbamic acid
 
 [Term]
 id: CHEBI:140601
 name: fatty acid 4:0
 def: "Any saturated fatty acid containing 4 carbons." []
 is_a: CHEBI:26666 ! short-chain fatty acid
-relationship: is_conjugate_acid_of CHEBI:78115 ! fatty acid anion 4:0
+relationship: RO:0018034 CHEBI:78115 ! is protonated form of fatty acid anion 4:0
 
 [Term]
 id: CHEBI:142163
 name: 24G7 epitope
-def: "An antigenic epitope recognized by an anti-bilirubin monoclonal antibody designated 24G7. A substructure of bilirubin IXalpha, it is the region containing the oxo group at C-1, the methyl group at C-2, C-(4, 5, 6, 9), and N-21 and -22." []
+def: "An antigenic epitope recognized by an anti-bilirubin monoclonal antibody designated 24G7. A substructure of bilirubin IXα, it is the region containing the oxo group at C-1, the methyl group at C-2, C-(4, 5, 6, 9), and N-21 and -22." []
 is_a: CHEBI:24433 ! group
 relationship: RO:0000087 CHEBI:53000 ! has role epitope
 
 [Term]
 id: CHEBI:14321
 name: glutamate(1-)
-def: "An alpha-amino-acid anion that is the conjugate base of glutamic acid, having anionic carboxy groups and a cationic amino group" []
+def: "An α-amino-acid anion that is the conjugate base of glutamic acid, having anionic carboxy groups and a cationic amino group" []
 is_a: CHEBI:33558 ! alpha-amino-acid anion
-relationship: is_conjugate_acid_of CHEBI:29987 ! glutamate(2-)
-relationship: is_conjugate_base_of CHEBI:18237 ! glutamic acid
 relationship: RO:0000087 CHEBI:78675 ! has role fundamental metabolite
+relationship: RO:0018033 CHEBI:18237 ! is deprotonated form of glutamic acid
+relationship: RO:0018034 CHEBI:29987 ! is protonated form of glutamate(2-)
 
 [Term]
 id: CHEBI:15339
@@ -216,6 +218,16 @@ relationship: RO:0000087 CHEBI:48356 ! has role protic solvent
 relationship: RO:0000087 CHEBI:64049 ! has role food acidity regulator
 relationship: RO:0000087 CHEBI:65256 ! has role antimicrobial food preservative
 relationship: RO:0000087 CHEBI:83056 ! has role Daphnia magna metabolite
+relationship: RO:0018034 CHEBI:30089 ! is protonated form of acetate
+
+[Term]
+id: CHEBI:15378
+name: hydron
+def: "The general name for the hydrogen nucleus, to be used without regard to the hydrogen nuclear mass (either for hydrogen in its natural abundance or where it is not desired to distinguish between the isotopes)." []
+is_a: CHEBI:25414 ! monoatomic monocation
+is_a: CHEBI:33251 ! monoatomic hydrogen
+is_a: CHEBI:33252 ! atomic nucleus
+is_a: CHEBI:60242 ! monovalent inorganic cation
 
 [Term]
 id: CHEBI:15379
@@ -231,20 +243,21 @@ relationship: RO:0000087 CHEBI:63248 ! has role oxidising agent
 relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
 relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
 relationship: RO:0000087 CHEBI:77974 ! has role food packaging gas
+relationship: RO:0018033 CHEBI:29793 ! is deprotonated form of hydridodioxygen(1+)
 
 [Term]
 id: CHEBI:15693
 name: aldose
-def: "Aldehydic parent sugars (polyhydroxy aldehydes H[CH(OH)]nC(=O)H, n >= 2) and their intramolecular hemiacetals." []
+def: "Aldehydic parent sugars (polyhydroxy aldehydes H[CH(OH)]<small><sub><em>n</em></sub></small>C(=O)H, <em>n</em> ≥ 2) and their intramolecular hemiacetals." []
 is_a: CHEBI:35381 ! monosaccharide
 
 [Term]
 id: CHEBI:15705
 name: L-alpha-amino acid
-def: "Any alpha-amino acid having L-configuration at the alpha-carbon." []
+def: "Any α-amino acid having <small>L</small>-configuration at the α-carbon." []
 is_a: CHEBI:33704 ! alpha-amino acid
-relationship: is_conjugate_acid_of CHEBI:59814 ! L-alpha-amino acid anion
-relationship: is_tautomer_of CHEBI:59869 ! L-alpha-amino acid zwitterion
+relationship: RO:0018034 CHEBI:59814 ! is protonated form of L-alpha-amino acid anion
+relationship: RO:0018036 CHEBI:59869 ! is tautomer of L-alpha-amino acid zwitterion
 
 [Term]
 id: CHEBI:15841
@@ -255,13 +268,13 @@ is_a: CHEBI:16670 ! peptide
 [Term]
 id: CHEBI:15966
 name: D-glutamic acid
-def: "An optically active form of glutamic acid having D-configuration." []
+def: "An optically active form of glutamic acid having <small>D</small>-configuration." []
 is_a: CHEBI:16733 ! D-alpha-amino acid
 is_a: CHEBI:18237 ! glutamic acid
-relationship: is_conjugate_acid_of CHEBI:29986 ! D-glutamate(1-)
-relationship: is_enantiomer_of CHEBI:16015 ! L-glutamic acid
 relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
 relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
+relationship: RO:0018034 CHEBI:29986 ! is protonated form of D-glutamate(1-)
+relationship: RO:0018039 CHEBI:16015 ! is enantiomer of L-glutamic acid
 
 [Term]
 id: CHEBI:15986
@@ -274,17 +287,17 @@ relationship: BFO:0000051 CHEBI:50319 ! has part nucleotide residue
 [Term]
 id: CHEBI:16015
 name: L-glutamic acid
-def: "An optically active form of glutamic acid having L-configuration." []
+def: "An optically active form of glutamic acid having <small>L</small>-configuration." []
 is_a: CHEBI:18237 ! glutamic acid
 is_a: CHEBI:24318 ! glutamine family amino acid
-relationship: is_conjugate_acid_of CHEBI:29985 ! L-glutamate(1-)
-relationship: is_enantiomer_of CHEBI:15966 ! D-glutamic acid
 relationship: RO:0000087 CHEBI:173085 ! has role ferroptosis inducer
 relationship: RO:0000087 CHEBI:25512 ! has role neurotransmitter
 relationship: RO:0000087 CHEBI:27027 ! has role micronutrient
 relationship: RO:0000087 CHEBI:50733 ! has role nutraceutical
 relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
 relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
+relationship: RO:0018034 CHEBI:29985 ! is protonated form of L-glutamate(1-)
+relationship: RO:0018039 CHEBI:15966 ! is enantiomer of D-glutamic acid
 
 [Term]
 id: CHEBI:16134
@@ -301,6 +314,8 @@ relationship: RO:0000087 CHEBI:59740 ! has role nucleophilic reagent
 relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
 relationship: RO:0000087 CHEBI:77941 ! has role EC 3.5.1.4 (amidase) inhibitor
 relationship: RO:0000087 CHEBI:78433 ! has role refrigerant
+relationship: RO:0018033 CHEBI:28938 ! is deprotonated form of ammonium
+relationship: RO:0018034 CHEBI:29337 ! is protonated form of azanide
 
 [Term]
 id: CHEBI:16189
@@ -313,15 +328,17 @@ relationship: is_conjugate_base_of CHEBI:45696 ! hydrogensulfate
 relationship: RO:0000087 CHEBI:23357 ! has role cofactor
 relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
 relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
+relationship: RO:0018033 CHEBI:45696 ! is deprotonated form of hydrogensulfate
 
 [Term]
 id: CHEBI:16336
 name: hyaluronic acid
-def: "A mucopolysaccharide composed of N-acetylglucosamine and glucuronic acid subunits. It is found in the connective tissues of vertebrates. A principal constituent of the extracellular matrix (ECM), it mediates the growth and metastasis of tumour cells." []
+def: "A mucopolysaccharide composed of <em>N</em>-acetylglucosamine and glucuronic acid subunits. It is found in the connective tissues of vertebrates. A principal constituent of the extracellular matrix (ECM), it mediates the growth and metastasis of tumour cells." []
 is_a: CHEBI:37395 ! mucopolysaccharide
 is_a: CHEBI:72813 ! exopolysaccharide
 relationship: is_conjugate_acid_of CHEBI:132153 ! hyaluronate
 relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
+relationship: RO:0018034 CHEBI:132153 ! is protonated form of hyaluronate
 
 [Term]
 id: CHEBI:16541
@@ -333,7 +350,7 @@ relationship: BFO:0000051 CHEBI:33700 ! has part proteinogenic amino-acid residu
 [Term]
 id: CHEBI:16646
 name: carbohydrate
-def: "Any member of the class of organooxygen compounds that is a polyhydroxy-aldehyde or -ketone or a lactol resulting from their intramolecular condensation (monosaccharides); substances derived from these by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom; and polymeric products arising by intermolecular acetal formation between two or more such molecules (disaccharides, polysaccharides and oligosaccharides). Carbohydrates contain only carbon, hydrogen and oxygen atoms; prior to any oxidation or reduction, most have the empirical formula Cm(H2O)n. Compounds obtained from carbohydrates by substitution, etc., are known as carbohydrate derivatives and may contain other elements. Cyclitols are generally not regarded as carbohydrates." []
+def: "Any member of the class of organooxygen compounds that is a polyhydroxy-aldehyde or -ketone or a lactol resulting from their intramolecular condensation (monosaccharides); substances derived from these by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom; and polymeric products arising by intermolecular acetal formation between two or more such molecules (disaccharides, polysaccharides and oligosaccharides). Carbohydrates contain only carbon, hydrogen and oxygen atoms; prior to any oxidation or reduction, most have the empirical formula C<small><sub><em>m</em></sub></small>(H<small><sub>2</sub></small>O)<small><sub><em>n</em></sub></small>. Compounds obtained from carbohydrates by substitution, etc., are known as carbohydrate derivatives and may contain other elements. Cyclitols are generally not regarded as carbohydrates." []
 is_a: CHEBI:78616 ! carbohydrates and carbohydrate derivatives
 
 [Term]
@@ -345,25 +362,27 @@ is_a: CHEBI:37622 ! carboxamide
 is_a: CHEBI:50047 ! organic amino compound
 relationship: BFO:0000051 CHEBI:33708 ! has part amino-acid residue
 relationship: is_tautomer_of CHEBI:60466 ! peptide zwitterion
+relationship: RO:0018036 CHEBI:60466 ! is tautomer of peptide zwitterion
 
 [Term]
 id: CHEBI:166902
 name: noradrenaline(1+)
+def: "An organic cation that is the conjugate acid of noradrenaline, obtained by protonation of the primary amino group; major species at pH 7.3." []
 is_a: CHEBI:25697 ! organic cation
 is_a: CHEBI:35274 ! ammonium ion derivative
-relationship: is_conjugate_acid_of CHEBI:33569 ! noradrenaline
+relationship: RO:0018034 CHEBI:33569 ! is protonated form of noradrenaline
 
 [Term]
 id: CHEBI:16733
 name: D-alpha-amino acid
 is_a: CHEBI:83925 ! non-proteinogenic alpha-amino acid
-relationship: is_conjugate_acid_of CHEBI:60895 ! D-alpha-amino acid anion
-relationship: is_tautomer_of CHEBI:59871 ! D-alpha-amino acid zwitterion
+relationship: RO:0018034 CHEBI:60895 ! is protonated form of D-alpha-amino acid anion
+relationship: RO:0018036 CHEBI:59871 ! is tautomer of D-alpha-amino acid zwitterion
 
 [Term]
 id: CHEBI:167559
 name: glycan
-def: "Any oligosaccharide, polysaccharide or their derivatives consisting of monosaccharides or monosaccharide derivatives linked by glycosidic bonds. See also http://www.ontobee.org/ontology/GNO?iri=http://purl.obolibrary.org/obo/GNO_00000001." []
+def: "Any oligosaccharide, polysaccharide or their derivatives consisting of monosaccharides or monosaccharide derivatives linked by glycosidic bonds. See also <a href=\"http://www.ontobee.org/ontology/GNO?iri=http://purl.obolibrary.org/obo/GNO_00000001\" target=\"_blank\">http://www.ontobee.org/ontology/GNO?iri=http://purl.obolibrary.org/obo/GNO_00000001</a>." []
 is_a: CHEBI:78616 ! carbohydrates and carbohydrate derivatives
 
 [Term]
@@ -378,20 +397,21 @@ relationship: is_conjugate_base_of CHEBI:57887 ! tryptaminium
 relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
 relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite
 relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
+relationship: RO:0018033 CHEBI:57887 ! is deprotonated form of tryptaminium
 
 [Term]
 id: CHEBI:16865
 name: gamma-aminobutyric acid
-def: "A gamma-amino acid that is butanoic acid with the amino substituent located at C-4." []
+def: "A γ-amino acid that is butanoic acid with the amino substituent located at C-4." []
 is_a: CHEBI:25384 ! monocarboxylic acid
 is_a: CHEBI:33707 ! gamma-amino acid
-relationship: has_functional_parent CHEBI:30772 ! butyric acid
-relationship: is_conjugate_acid_of CHEBI:30566 ! gamma-aminobutyrate
-relationship: is_tautomer_of CHEBI:59888 ! gamma-aminobutyric acid zwitterion
 relationship: RO:0000087 CHEBI:25512 ! has role neurotransmitter
 relationship: RO:0000087 CHEBI:62488 ! has role signalling molecule
 relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
 relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
+relationship: RO:0018034 CHEBI:30566 ! is protonated form of gamma-aminobutyrate
+relationship: RO:0018036 CHEBI:59888 ! is tautomer of gamma-aminobutyric acid zwitterion
+relationship: RO:0018038 CHEBI:30772 ! has functional parent butyric acid
 
 [Term]
 id: CHEBI:16990
@@ -400,15 +420,15 @@ def: "A member of the class of  biladienes that is a linear tetrapyrrole with th
 is_a: CHEBI:35692 ! dicarboxylic acid
 is_a: CHEBI:36735 ! biladienes
 relationship: BFO:0000051 CHEBI:142163 ! has part 24G7 epitope
-relationship: is_conjugate_acid_of CHEBI:57977 ! bilirubin(2-)
 relationship: RO:0000087 CHEBI:22586 ! has role antioxidant
 relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
 relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
+relationship: RO:0018034 CHEBI:57977 ! is protonated form of bilirubin(2-)
 
 [Term]
 id: CHEBI:17087
 name: ketone
-def: "A compound in which a carbonyl group is bonded to two carbon atoms: R2C=O (neither R may be H)." []
+def: "A compound in which a carbonyl group is bonded to two carbon atoms: R<small><sub>2</sub></small>C=O (neither R may be H)." []
 is_a: CHEBI:36586 ! carbonyl compound
 
 [Term]
@@ -436,25 +456,25 @@ id: CHEBI:17544
 name: hydrogencarbonate
 def: "The carbon oxoanion resulting from the removal of a proton from carbonic acid." []
 is_a: CHEBI:35604 ! carbon oxoanion
-relationship: is_conjugate_acid_of CHEBI:41609 ! carbonate
-relationship: is_conjugate_base_of CHEBI:28976 ! carbonic acid
 relationship: RO:0000087 CHEBI:23357 ! has role cofactor
 relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
 relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
 relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
 relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
+relationship: RO:0018033 CHEBI:28976 ! is deprotonated form of carbonic acid
+relationship: RO:0018034 CHEBI:41609 ! is protonated form of carbonate
 
 [Term]
 id: CHEBI:17608
 name: D-aldohexose
-def: "Any D-aldose having a chain of six carbon atoms in the molecule." []
+def: "Any <small>D</small>-aldose having a chain of six carbon atoms in the molecule." []
 is_a: CHEBI:33917 ! aldohexose
 is_a: CHEBI:4194 ! D-hexose
 
 [Term]
 id: CHEBI:17634
 name: D-glucose
-def: "A glucose with D-configuration." []
+def: "A glucose with <small>D</small>-configuration." []
 is_a: CHEBI:17234 ! glucose
 is_a: CHEBI:17608 ! D-aldohexose
 
@@ -475,9 +495,9 @@ id: CHEBI:17968
 name: butyrate
 def: "A short-chain fatty acid anion that is the conjugate base of butyric acid, obtained by deprotonation of the carboxy group." []
 is_a: CHEBI:78115 ! fatty acid anion 4:0
-relationship: is_conjugate_base_of CHEBI:30772 ! butyric acid
 relationship: RO:0000087 CHEBI:61115 ! has role EC 3.5.1.98 (histone deacetylase) inhibitor
 relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
+relationship: RO:0018033 CHEBI:30772 ! is deprotonated form of butyric acid
 
 [Term]
 id: CHEBI:18059
@@ -508,12 +528,12 @@ is_a: CHEBI:33694 ! biomacromolecule
 [Term]
 id: CHEBI:18237
 name: glutamic acid
-def: "An alpha-amino acid that is glutaric acid bearing a single amino substituent at position 2." []
+def: "An α-amino acid that is glutaric acid bearing a single amino substituent at position 2." []
 is_a: CHEBI:26167 ! polar amino acid
 is_a: CHEBI:33704 ! alpha-amino acid
 relationship: BFO:0000051 CHEBI:50329 ! has part 2-carboxyethyl group
-relationship: is_conjugate_acid_of CHEBI:14321 ! glutamate(1-)
 relationship: RO:0000087 CHEBI:78675 ! has role fundamental metabolite
+relationship: RO:0018034 CHEBI:14321 ! is protonated form of glutamate(1-)
 
 [Term]
 id: CHEBI:18282
@@ -524,15 +544,15 @@ is_a: CHEBI:38101 ! organonitrogen heterocyclic compound
 [Term]
 id: CHEBI:18357
 name: (R)-noradrenaline
-def: "The R-enantiomer of noradrenaline." []
+def: "The <i>R</i>-enantiomer of noradrenaline." []
 is_a: CHEBI:33569 ! noradrenaline
-relationship: is_conjugate_base_of CHEBI:72587 ! (R)-noradrenaline(1+)
-relationship: is_enantiomer_of CHEBI:33571 ! (S)-noradrenaline
 relationship: RO:0000087 CHEBI:25512 ! has role neurotransmitter
 relationship: RO:0000087 CHEBI:35524 ! has role sympathomimetic agent
 relationship: RO:0000087 CHEBI:35569 ! has role alpha-adrenergic agonist
 relationship: RO:0000087 CHEBI:50514 ! has role vasoconstrictor agent
 relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
+relationship: RO:0018033 CHEBI:72587 ! is deprotonated form of (R)-noradrenaline(1+)
+relationship: RO:0018039 CHEBI:33571 ! is enantiomer of (S)-noradrenaline
 
 [Term]
 id: CHEBI:20664
@@ -542,7 +562,7 @@ is_a: CHEBI:35519 ! cholane
 [Term]
 id: CHEBI:22221
 name: acyl group
-def: "An organic group formed by removing one or more hydroxy groups from an oxoacid that has the general structure RkE(=O)l(OH)m (l =/= 0). Although the term is almost always applied to organic compounds, with carboxylic acid as the oxoacid, acyl groups can in principle be derived from other types of acids such as sulfonic acids or phosphonic acids." []
+def: "An organic group formed by removing one or more hydroxy groups from an oxoacid that has the general structure R<small><sub><em>k</em></sub></small>E(=O)<small><sub><em>l</em></sub></small>(OH)<small><sub><em>m</em></sub></small> (<em>l</em> ≠ 0). Although the term is almost always applied to organic compounds, with carboxylic acid as the oxoacid, acyl groups can in principle be derived from other types of acids such as sulfonic acids or phosphonic acids." []
 is_a: CHEBI:33247 ! organic group
 
 [Term]
@@ -610,6 +630,7 @@ name: carbamoyl group
 def: "The univalent carboacyl group formed by loss of -OH from the carboxy group of carbamic acid." []
 is_a: CHEBI:27207 ! univalent carboacyl group
 relationship: is_substituent_group_from CHEBI:28616 ! carbamic acid
+relationship: RO:0018037 CHEBI:28616 ! is substitutent group from carbamic acid
 
 [Term]
 id: CHEBI:23019
@@ -628,6 +649,14 @@ name: molecular entity
 def: "Any constitutionally or isotopically distinct atom, molecule, ion, ion pair, radical, radical ion, complex, conformer etc., identifiable as a separately distinguishable entity." []
 is_a: CHEBI:24431 ! chemical entity
 
+[Term]
+id: CHEBI:234420
+name: (S)-noradrenaline(1+)
+def: "An organic cation that is the conjugate acid of (<i>S</i>)-noradrenaline, obtained by protonation of the primary amino group; major species at pH 7.3." []
+is_a: CHEBI:166902 ! noradrenaline(1+)
+relationship: RO:0018034 CHEBI:33571 ! is protonated form of (S)-noradrenaline
+relationship: RO:0018039 CHEBI:72587 ! is enantiomer of (R)-noradrenaline(1+)
+
 [Term]
 id: CHEBI:23449
 name: cyclic peptide
@@ -655,14 +684,14 @@ is_a: CHEBI:52206 ! biochemical role
 [Term]
 id: CHEBI:24318
 name: glutamine family amino acid
-def: "An L-alpha-amino acid which is L-glutamic acid or any of the essential amino acids biosynthesised from it (glutamine, proline and arginine). A closed class." []
+def: "An <small>L</small>-α-amino acid which is <small>L</small>-glutamic acid or any of the essential amino acids biosynthesised from it (glutamine, proline and arginine). A closed class." []
 is_a: CHEBI:15705 ! L-alpha-amino acid
 is_a: CHEBI:83813 ! proteinogenic amino acid
 
 [Term]
 id: CHEBI:24319
 name: EC 6.3.1.2 (glutamate--ammonia ligase) inhibitor
-def: "An EC 6.3.* (C-N bond-forming ligase) inhibitor that interferes with the action of glutamate--ammonia ligase (EC 6.3.1.2)." []
+def: "An EC 6.3.* (<em>C</em>‒<em>N</em> bond-forming ligase) inhibitor that interferes with the action of glutamate—ammonia ligase (EC 6.3.1.2)." []
 is_a: CHEBI:76823 ! EC 6.3.1.* (acid-ammonia/amine ligase) inhibitor
 
 [Term]
@@ -714,7 +743,8 @@ is_a: CHEBI:48705 ! agonist
 id: CHEBI:24636
 name: proton
 def: "Nuclear particle of charge number +1, spin 1/2 and rest mass of 1.007276470(12) u." []
-is_a: CHEBI:36342 ! subatomic particle
+is_a: CHEBI:15378 ! hydron
+is_a: CHEBI:33253 ! nucleon
 is_a: COB:0000013 ! molecule
 
 [Term]
@@ -729,10 +759,10 @@ relationship: BFO:0000051 CHEBI:43176 ! has part hydroxy group
 [Term]
 id: CHEBI:24663
 name: hydroxy-5beta-cholanic acid
-def: "Any member of the class of 5beta-cholanic acids carrying at least one hydroxy group at unspecified position." []
+def: "Any member of the class of 5β-cholanic acids carrying at least one hydroxy group at unspecified position." []
 is_a: CHEBI:33822 ! organic hydroxy compound
 is_a: CHEBI:36248 ! 5beta-cholanic acids
-relationship: has_functional_parent CHEBI:36238 ! 5beta-cholanic acid
+relationship: RO:0018038 CHEBI:36238 ! has functional parent 5beta-cholanic acid
 
 [Term]
 id: CHEBI:24828
@@ -771,7 +801,6 @@ name: salt
 def: "A salt is an assembly of cations and anions." []
 is_a: CHEBI:37577 ! heteroatomic molecular entity
 relationship: BFO:0000051 CHEBI:22563 ! has part anion
-relationship: BFO:0000051 CHEBI:36916 ! has part cation
 
 [Term]
 id: CHEBI:24867
@@ -833,6 +862,7 @@ name: monocarboxylic acid
 def: "An oxoacid containing a single carboxy group." []
 is_a: CHEBI:33575 ! carboxylic acid
 relationship: is_conjugate_acid_of CHEBI:35757 ! monocarboxylic acid anion
+relationship: RO:0018034 CHEBI:35757 ! is protonated form of monocarboxylic acid anion
 
 [Term]
 id: CHEBI:25414
@@ -883,6 +913,7 @@ name: organic sulfate
 def: "Compounds of the general formula SO3HOR where R is an organyl group" []
 is_a: CHEBI:26820 ! sulfates
 relationship: is_conjugate_acid_of CHEBI:58958 ! organosulfate oxoanion
+relationship: RO:0018034 CHEBI:58958 ! is protonated form of organosulfate oxoanion
 
 [Term]
 id: CHEBI:25741
@@ -916,7 +947,7 @@ id: CHEBI:26167
 name: polar amino acid
 def: "Any amino acid whose side chain is capable of forming one or more hydrogen bonds." []
 is_a: CHEBI:33709 ! amino acid
-relationship: is_tautomer_of CHEBI:62031 ! polar amino acid zwitterion
+relationship: RO:0018036 CHEBI:62031 ! is tautomer of polar amino acid zwitterion
 
 [Term]
 id: CHEBI:26607
@@ -927,9 +958,9 @@ is_a: CHEBI:35366 ! fatty acid
 [Term]
 id: CHEBI:26666
 name: short-chain fatty acid
-def: "An aliphatic monocarboxylic acid with a chain length of less than C6. If any non-hydrocarbon substituent is present, the compound is not normally regarded as a short-chain fatty acid." []
+def: "An aliphatic monocarboxylic acid with a chain length of less than C<small><sub>6</sub></small>. If any non-hydrocarbon substituent is present, the compound is not normally regarded as a short-chain fatty acid." []
 is_a: CHEBI:35366 ! fatty acid
-relationship: is_conjugate_acid_of CHEBI:58951 ! short-chain fatty acid anion
+relationship: RO:0018034 CHEBI:58951 ! is protonated form of short-chain fatty acid anion
 
 [Term]
 id: CHEBI:26708
@@ -992,6 +1023,7 @@ def: "A sulfur oxoacid that consists of two oxo and two hydroxy groups joined co
 is_a: CHEBI:33402 ! sulfur oxoacid
 relationship: is_conjugate_acid_of CHEBI:45696 ! hydrogensulfate
 relationship: RO:0000087 CHEBI:35223 ! has role catalyst
+relationship: RO:0018034 CHEBI:45696 ! is protonated form of hydrogensulfate
 
 [Term]
 id: CHEBI:26932
@@ -1040,7 +1072,7 @@ relationship: RO:0000087 CHEBI:33937 ! has role macronutrient
 [Term]
 id: CHEBI:28087
 name: glycogen
-def: "A polydisperse, highly branched glucan composed of chains of D-glucopyranose residues in alpha(1->4) glycosidic linkage, joined together by alpha(1->6) glycosidic linkages. A small number of alpha(1->3) glycosidic linkages and some cumulative alpha(1->6) links also may occur. The branches in glycogen typically contain 8 to 12 glucose residues." []
+def: "A polydisperse, highly branched glucan composed of chains of <small>D</small>-glucopyranose residues in α(1→4) glycosidic linkage, joined together by α(1→6) glycosidic linkages. A small number of α(1→3) glycosidic linkages and some cumulative α(1→6) links also may occur. The branches in glycogen typically contain 8 to 12 glucose residues." []
 is_a: CHEBI:24384 ! glycogens
 relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
 relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
@@ -1054,6 +1086,7 @@ is_a: CHEBI:35605 ! carbon oxoacid
 is_a: CHEBI:64708 ! one-carbon compound
 relationship: is_conjugate_acid_of CHEBI:13941 ! carbamate
 relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
+relationship: RO:0018034 CHEBI:13941 ! is protonated form of carbamate
 
 [Term]
 id: CHEBI:28790
@@ -1069,6 +1102,8 @@ relationship: is_conjugate_base_of CHEBI:350546 ! serotonin(1+)
 relationship: RO:0000087 CHEBI:25512 ! has role neurotransmitter
 relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
 relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
+relationship: RO:0018033 CHEBI:350546 ! is deprotonated form of serotonin(1+)
+relationship: RO:0018038 CHEBI:16765 ! has functional parent tryptamine
 
 [Term]
 id: CHEBI:28868
@@ -1076,7 +1111,7 @@ name: fatty acid anion
 def: "The conjugate base of a fatty acid, arising from deprotonation of the carboxylic acid group of the corresponding fatty acid." []
 is_a: CHEBI:18059 ! lipid
 is_a: CHEBI:35757 ! monocarboxylic acid anion
-relationship: is_conjugate_base_of CHEBI:35366 ! fatty acid
+relationship: RO:0018033 CHEBI:35366 ! is deprotonated form of fatty acid
 
 [Term]
 id: CHEBI:28938
@@ -1090,6 +1125,7 @@ relationship: RO:0000087 CHEBI:23357 ! has role cofactor
 relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
 relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
 relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
+relationship: RO:0018034 CHEBI:16134 ! is protonated form of ammonia
 
 [Term]
 id: CHEBI:28965
@@ -1103,8 +1139,8 @@ id: CHEBI:28976
 name: carbonic acid
 is_a: CHEBI:35605 ! carbon oxoacid
 is_a: CHEBI:36961 ! chalcocarbonic acid
-relationship: is_conjugate_acid_of CHEBI:17544 ! hydrogencarbonate
 relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
+relationship: RO:0018034 CHEBI:17544 ! is protonated form of hydrogencarbonate
 
 [Term]
 id: CHEBI:29067
@@ -1113,6 +1149,7 @@ def: "The conjugate base formed when the carboxy group of a carboxylic acid is d
 is_a: CHEBI:25696 ! organic anion
 is_a: CHEBI:35406 ! oxoanion
 relationship: is_conjugate_base_of CHEBI:33575 ! carboxylic acid
+relationship: RO:0018033 CHEBI:33575 ! is deprotonated form of carboxylic acid
 
 [Term]
 id: CHEBI:29101
@@ -1132,6 +1169,8 @@ is_a: CHEBI:35106 ! nitrogen hydride
 is_a: CHEBI:79389 ! monovalent inorganic anion
 relationship: is_conjugate_acid_of CHEBI:29340 ! hydridonitrate(2-)
 relationship: is_conjugate_base_of CHEBI:16134 ! ammonia
+relationship: RO:0018033 CHEBI:16134 ! is deprotonated form of ammonia
+relationship: RO:0018034 CHEBI:29340 ! is protonated form of hydridonitrate(2-)
 
 [Term]
 id: CHEBI:29340
@@ -1140,57 +1179,59 @@ def: "A divalent inorganic anion resulting from the removal of two protons from
 is_a: CHEBI:35106 ! nitrogen hydride
 is_a: CHEBI:79388 ! divalent inorganic anion
 relationship: is_conjugate_base_of CHEBI:29337 ! azanide
+relationship: RO:0018033 CHEBI:29337 ! is deprotonated form of azanide
 
 [Term]
 id: CHEBI:29793
 name: hydridodioxygen(1+)
 is_a: CHEBI:33693 ! oxygen hydride
 relationship: is_conjugate_acid_of CHEBI:15379 ! dioxygen
+relationship: RO:0018034 CHEBI:15379 ! is protonated form of dioxygen
 
 [Term]
 id: CHEBI:29985
 name: L-glutamate(1-)
-def: "An alpha-amino-acid anion that is the conjugate base of L-glutamic acid, having anionic carboxy groups and a cationic amino group" []
+def: "An α-amino-acid anion that is the conjugate base of <small>L</small>-glutamic acid, having anionic carboxy groups and a cationic amino group" []
 is_a: CHEBI:14321 ! glutamate(1-)
-relationship: is_conjugate_acid_of CHEBI:29988 ! L-glutamate(2-)
-relationship: is_conjugate_base_of CHEBI:16015 ! L-glutamic acid
-relationship: is_enantiomer_of CHEBI:29986 ! D-glutamate(1-)
 relationship: RO:0000087 CHEBI:24319 ! has role EC 6.3.1.2 (glutamate--ammonia ligase) inhibitor
 relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
 relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
+relationship: RO:0018033 CHEBI:16015 ! is deprotonated form of L-glutamic acid
+relationship: RO:0018034 CHEBI:29988 ! is protonated form of L-glutamate(2-)
+relationship: RO:0018039 CHEBI:29986 ! is enantiomer of D-glutamate(1-)
 
 [Term]
 id: CHEBI:29986
 name: D-glutamate(1-)
-def: "An alpha-amino-acid anion that is the conjugate base of D-glutamic acid, having anionic carboxy groups and a cationic amino group" []
+def: "An α-amino-acid anion that is the conjugate base of <small>D</small>-glutamic acid, having anionic carboxy groups and a cationic amino group" []
 is_a: CHEBI:14321 ! glutamate(1-)
-relationship: is_conjugate_acid_of CHEBI:29989 ! D-glutamate(2-)
-relationship: is_conjugate_base_of CHEBI:15966 ! D-glutamic acid
-relationship: is_enantiomer_of CHEBI:29985 ! L-glutamate(1-)
+relationship: RO:0018033 CHEBI:15966 ! is deprotonated form of D-glutamic acid
+relationship: RO:0018034 CHEBI:29989 ! is protonated form of D-glutamate(2-)
+relationship: RO:0018039 CHEBI:29985 ! is enantiomer of L-glutamate(1-)
 
 [Term]
 id: CHEBI:29987
 name: glutamate(2-)
-def: "A dicarboxylic acid dianion that is the conjugate base of glutamate(1-)." []
+def: "A dicarboxylic acid dianion that is the conjugate base of glutamate(1−)." []
 is_a: CHEBI:28965 ! dicarboxylic acid dianion
-relationship: is_conjugate_base_of CHEBI:14321 ! glutamate(1-)
 relationship: RO:0000087 CHEBI:78675 ! has role fundamental metabolite
+relationship: RO:0018033 CHEBI:14321 ! is deprotonated form of glutamate(1-)
 
 [Term]
 id: CHEBI:29988
 name: L-glutamate(2-)
-def: "An L-alpha-amino acid anion that is the dianion obtained by the deprotonation of the both the carboxy groups of L-glutamic acid." []
+def: "An <small>L</small>-α-amino acid anion that is the dianion obtained by the deprotonation of the both the carboxy groups of <small>L</small>-glutamic acid." []
 is_a: CHEBI:29987 ! glutamate(2-)
 is_a: CHEBI:59814 ! L-alpha-amino acid anion
-relationship: is_conjugate_base_of CHEBI:29985 ! L-glutamate(1-)
-relationship: is_enantiomer_of CHEBI:29989 ! D-glutamate(2-)
+relationship: RO:0018033 CHEBI:29985 ! is deprotonated form of L-glutamate(1-)
+relationship: RO:0018039 CHEBI:29989 ! is enantiomer of D-glutamate(2-)
 
 [Term]
 id: CHEBI:29989
 name: D-glutamate(2-)
 is_a: CHEBI:29987 ! glutamate(2-)
-relationship: is_conjugate_base_of CHEBI:29986 ! D-glutamate(1-)
-relationship: is_enantiomer_of CHEBI:29988 ! L-glutamate(2-)
+relationship: RO:0018033 CHEBI:29986 ! is deprotonated form of D-glutamate(1-)
+relationship: RO:0018039 CHEBI:29988 ! is enantiomer of L-glutamate(2-)
 
 [Term]
 id: CHEBI:30089
@@ -1200,21 +1241,22 @@ is_a: CHEBI:35757 ! monocarboxylic acid anion
 relationship: is_conjugate_base_of CHEBI:15366 ! acetic acid
 relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
 relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
+relationship: RO:0018033 CHEBI:15366 ! is deprotonated form of acetic acid
 
 [Term]
 id: CHEBI:30212
 name: photon
-def: "Particle of zero charge, zero rest mass, spin quantum number 1, energy hnu and momentum hnu/c (h is the Planck constant, nu the frequency of radiation and c the speed of light), carrier of electromagnetic force." []
+def: "Particle of zero charge, zero rest mass, spin quantum number 1, energy <em>h</em><em>ν</em> and momentum <em>h</em><em>ν</em>/<em>c</em> (<em>h</em> is the Planck constant, <em>ν</em> the frequency of radiation and <em>c</em> the speed of light), carrier of electromagnetic force." []
 is_a: CHEBI:36341 ! boson
 
 [Term]
 id: CHEBI:30566
 name: gamma-aminobutyrate
-def: "An gamma-amino acid anion resulting from the deprotonation of the carboxy group of gamma-aminobutyric acid." []
+def: "An γ-amino acid anion resulting from the deprotonation of the carboxy group of γ-aminobutyric acid." []
 is_a: CHEBI:71666 ! gamma-amino acid anion
-relationship: has_functional_parent CHEBI:17968 ! butyrate
-relationship: is_conjugate_base_of CHEBI:16865 ! gamma-aminobutyric acid
 relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
+relationship: RO:0018033 CHEBI:16865 ! is deprotonated form of gamma-aminobutyric acid
+relationship: RO:0018038 CHEBI:17968 ! has functional parent butyrate
 
 [Term]
 id: CHEBI:30772
@@ -1222,14 +1264,14 @@ name: butyric acid
 def: "A straight-chain saturated fatty acid that is butane in which one of the terminal methyl groups has been oxidised to a carboxy group." []
 is_a: CHEBI:140601 ! fatty acid 4:0
 is_a: CHEBI:39418 ! straight-chain saturated fatty acid
-relationship: is_conjugate_acid_of CHEBI:17968 ! butyrate
 relationship: RO:0000087 CHEBI:131604 ! has role Mycoplasma genitalium metabolite
 relationship: RO:0000087 CHEBI:84087 ! has role human urinary metabolite
+relationship: RO:0018034 CHEBI:17968 ! is protonated form of butyrate
 
 [Term]
 id: CHEBI:3098
 name: bile acid
-def: "Any member of a group of hydroxy-5beta-cholanic acids occuring in bile, where they are present as the sodium salts of their amides with glycine or taurine. In mammals bile acids almost invariably have 5beta-configuration." []
+def: "Any member of a group of hydroxy-5β-cholanic acids occuring in bile, where they are present as the sodium salts of their amides with glycine or taurine. In mammals bile acids almost invariably have 5β-configuration." []
 is_a: CHEBI:138366 ! bile acids
 is_a: CHEBI:24663 ! hydroxy-5beta-cholanic acid
 
@@ -1242,7 +1284,7 @@ is_a: CHEBI:50047 ! organic amino compound
 [Term]
 id: CHEBI:32988
 name: amide
-def: "An amide is a derivative of an oxoacid RkE(=O)l(OH)m (l =/= 0) in which an acidic hydroxy group has been replaced by an amino or substituted amino group." []
+def: "An amide is a derivative of an oxoacid R<small><sub><em>k</em></sub></small>E(=O)<small><sub><em>l</em></sub></small>(OH)<small><sub><em>m</em></sub></small> (<em>l</em> ≠ 0) in which an acidic hydroxy group has been replaced by an amino or substituted amino group." []
 is_a: CHEBI:51143 ! nitrogen molecular entity
 
 [Term]
@@ -1268,6 +1310,7 @@ id: CHEBI:33241
 name: oxoacid derivative
 is_a: CHEBI:37577 ! heteroatomic molecular entity
 relationship: has_functional_parent CHEBI:24833 ! oxoacid
+relationship: RO:0018038 CHEBI:24833 ! has functional parent oxoacid
 
 [Term]
 id: CHEBI:33242
@@ -1295,6 +1338,8 @@ def: "Any substituent group or skeleton containing carbon." []
 is_a: CHEBI:24433 ! group
 relationship: is_conjugate_acid_of CHEBI:64775 ! organic anionic group
 relationship: is_conjugate_base_of CHEBI:64769 ! organic cationic group
+relationship: RO:0018033 CHEBI:64769 ! is deprotonated form of organic cationic group
+relationship: RO:0018034 CHEBI:64775 ! is protonated form of organic anionic group
 
 [Term]
 id: CHEBI:33249
@@ -1307,9 +1352,14 @@ id: CHEBI:33250
 name: atom
 def: "A chemical entity constituting the smallest component of an element having the chemical properties of the element." []
 is_a: CHEBI:24431 ! chemical entity
-relationship: BFO:0000051 CHEBI:10545 ! has part electron
 relationship: BFO:0000051 CHEBI:33252 ! has part atomic nucleus
 
+[Term]
+id: CHEBI:33251
+name: monoatomic hydrogen
+is_a: CHEBI:33238 ! monoatomic entity
+is_a: CHEBI:33260 ! elemental hydrogen
+
 [Term]
 id: CHEBI:33252
 name: atomic nucleus
@@ -1327,7 +1377,7 @@ is_a: CHEBI:36347 ! nuclear particle
 [Term]
 id: CHEBI:33256
 name: primary amide
-def: "A derivative of an oxoacid RkE(=O)l(OH)m (l =/= 0) in which an acidic hydroxy group has been replaced by an amino or substituted amino group." []
+def: "A derivative of an oxoacid R<small><sub><em>k</em></sub></small>E(=O)<small><sub><em>l</em></sub></small>(OH)<small><sub><em>m</em></sub></small> (<em>l</em> ≠ 0) in which an acidic hydroxy group has been replaced by an amino or substituted amino group." []
 is_a: CHEBI:32988 ! amide
 
 [Term]
@@ -1336,6 +1386,13 @@ name: elemental molecular entity
 def: "A molecular entity all atoms of which have the same atomic number." []
 is_a: CHEBI:23367 ! molecular entity
 
+[Term]
+id: CHEBI:33260
+name: elemental hydrogen
+is_a: CHEBI:24835 ! inorganic molecular entity
+is_a: CHEBI:33259 ! elemental molecular entity
+is_a: CHEBI:33608 ! hydrogen molecular entity
+
 [Term]
 id: CHEBI:33262
 name: elemental oxygen
@@ -1475,6 +1532,7 @@ name: alpha-amino-acid anion
 def: "An amino-acid anion obtained by deprotonation of any alpha-amino acid." []
 is_a: CHEBI:37022 ! amino-acid anion
 relationship: is_conjugate_base_of CHEBI:33704 ! alpha-amino acid
+relationship: RO:0018033 CHEBI:33704 ! is deprotonated form of alpha-amino acid
 
 [Term]
 id: CHEBI:33559
@@ -1490,7 +1548,7 @@ is_a: CHEBI:33318 ! main group element atom
 [Term]
 id: CHEBI:33566
 name: catechols
-def: "Any compound containing an o-diphenol component." []
+def: "Any compound containing an <em>o</em>-diphenol component." []
 is_a: CHEBI:33570 ! benzenediols
 
 [Term]
@@ -1505,8 +1563,8 @@ id: CHEBI:33569
 name: noradrenaline
 def: "A catecholamine in which C-1 of the aminoethyl side-chain is hydroxy-substituted." []
 is_a: CHEBI:33567 ! catecholamine
-relationship: is_conjugate_base_of CHEBI:166902 ! noradrenaline(1+)
 relationship: RO:0000087 CHEBI:76967 ! has role human xenobiotic metabolite
+relationship: RO:0018033 CHEBI:166902 ! is deprotonated form of noradrenaline(1+)
 
 [Term]
 id: CHEBI:33570
@@ -1516,9 +1574,10 @@ is_a: CHEBI:33853 ! phenols
 [Term]
 id: CHEBI:33571
 name: (S)-noradrenaline
-def: "The S-enantiomer of noradrenaline." []
+def: "The <i>S</i>-enantiomer of noradrenaline." []
 is_a: CHEBI:33569 ! noradrenaline
-relationship: is_enantiomer_of CHEBI:18357 ! (R)-noradrenaline
+relationship: RO:0018033 CHEBI:234420 ! is deprotonated form of (S)-noradrenaline(1+)
+relationship: RO:0018039 CHEBI:18357 ! is enantiomer of (R)-noradrenaline
 
 [Term]
 id: CHEBI:33575
@@ -1529,6 +1588,7 @@ is_a: CHEBI:36586 ! carbonyl compound
 is_a: CHEBI:64709 ! organic acid
 relationship: BFO:0000051 CHEBI:46883 ! has part carboxy group
 relationship: is_conjugate_acid_of CHEBI:29067 ! carboxylic acid anion
+relationship: RO:0018034 CHEBI:29067 ! is protonated form of carboxylic acid anion
 
 [Term]
 id: CHEBI:33579
@@ -1553,7 +1613,6 @@ is_a: CHEBI:25367 ! molecule
 id: CHEBI:33608
 name: hydrogen molecular entity
 is_a: CHEBI:33674 ! s-block molecular entity
-relationship: BFO:0000051 CHEBI:49637 ! has part hydrogen atom
 
 [Term]
 id: CHEBI:33635
@@ -1597,7 +1656,6 @@ id: CHEBI:33674
 name: s-block molecular entity
 def: "An s-block molecular entity is a molecular entity containing one or more atoms of an s-block element." []
 is_a: CHEBI:33579 ! main group molecular entity
-relationship: BFO:0000051 CHEBI:33559 ! has part s-block element atom
 
 [Term]
 id: CHEBI:33675
@@ -1633,7 +1691,7 @@ is_a: CHEBI:33694 ! biomacromolecule
 [Term]
 id: CHEBI:33696
 name: nucleic acid
-def: "A macromolecule made up of nucleotide units and hydrolysable into certain pyrimidine or purine bases (usually adenine, cytosine, guanine, thymine, uracil), D-ribose or 2-deoxy-D-ribose and phosphoric acid." []
+def: "A macromolecule made up of nucleotide units and hydrolysable into certain pyrimidine or purine bases (usually adenine, cytosine, guanine, thymine, uracil), <small>D</small>-ribose or 2-deoxy-<small>D</small>-ribose and phosphoric acid." []
 is_a: CHEBI:15986 ! polynucleotide
 relationship: BFO:0000051 CHEBI:33791 ! has part canonical nucleoside residue
 relationship: BFO:0000051 CHEBI:50297 ! has part canonical nucleotide residue
@@ -1664,6 +1722,7 @@ name: amino-acid cation
 is_a: CHEBI:25697 ! organic cation
 is_a: CHEBI:33702 ! polyatomic cation
 relationship: is_conjugate_acid_of CHEBI:33709 ! amino acid
+relationship: RO:0018034 CHEBI:33709 ! is protonated form of amino acid
 
 [Term]
 id: CHEBI:33704
@@ -1673,13 +1732,16 @@ is_a: CHEBI:33709 ! amino acid
 relationship: is_conjugate_acid_of CHEBI:33558 ! alpha-amino-acid anion
 relationship: is_conjugate_base_of CHEBI:33719 ! alpha-amino-acid cation
 relationship: is_tautomer_of CHEBI:78608 ! alpha-amino-acid zwitterion
+relationship: RO:0018033 CHEBI:33719 ! is deprotonated form of alpha-amino-acid cation
+relationship: RO:0018034 CHEBI:33558 ! is protonated form of alpha-amino-acid anion
+relationship: RO:0018036 CHEBI:78608 ! is tautomer of alpha-amino-acid zwitterion
 
 [Term]
 id: CHEBI:33707
 name: gamma-amino acid
-def: "A non-proteinogenic amino-acid in which the amino group is located on the carbon atom at the position gamma to the carboxy group." []
+def: "A non-proteinogenic amino-acid in which the amino group is located on the carbon atom at the position γ to the carboxy group." []
 is_a: CHEBI:83820 ! non-proteinogenic amino acid
-relationship: is_conjugate_acid_of CHEBI:71666 ! gamma-amino acid anion
+relationship: RO:0018034 CHEBI:71666 ! is protonated form of gamma-amino acid anion
 
 [Term]
 id: CHEBI:33708
@@ -1689,6 +1751,9 @@ is_a: CHEBI:33247 ! organic group
 relationship: is_conjugate_acid_of CHEBI:64898 ! anionic amino-acid residue
 relationship: is_conjugate_base_of CHEBI:58942 ! cationic amino-acid residue
 relationship: is_substituent_group_from CHEBI:33709 ! amino acid
+relationship: RO:0018033 CHEBI:58942 ! is deprotonated form of cationic amino-acid residue
+relationship: RO:0018034 CHEBI:64898 ! is protonated form of anionic amino-acid residue
+relationship: RO:0018037 CHEBI:33709 ! is substitutent group from amino acid
 
 [Term]
 id: CHEBI:33709
@@ -1698,6 +1763,8 @@ is_a: CHEBI:33575 ! carboxylic acid
 is_a: CHEBI:50047 ! organic amino compound
 relationship: is_conjugate_acid_of CHEBI:37022 ! amino-acid anion
 relationship: is_conjugate_base_of CHEBI:33703 ! amino-acid cation
+relationship: RO:0018033 CHEBI:33703 ! is deprotonated form of amino-acid cation
+relationship: RO:0018034 CHEBI:37022 ! is protonated form of amino-acid anion
 
 [Term]
 id: CHEBI:33710
@@ -1705,12 +1772,14 @@ name: alpha-amino-acid residue
 def: "An amino-acid residue derived from an alpha-amino acid." []
 is_a: CHEBI:33708 ! amino-acid residue
 relationship: is_substituent_group_from CHEBI:33704 ! alpha-amino acid
+relationship: RO:0018037 CHEBI:33704 ! is substitutent group from alpha-amino acid
 
 [Term]
 id: CHEBI:33719
 name: alpha-amino-acid cation
 is_a: CHEBI:33703 ! amino-acid cation
 relationship: is_conjugate_acid_of CHEBI:33704 ! alpha-amino acid
+relationship: RO:0018034 CHEBI:33704 ! is protonated form of alpha-amino acid
 
 [Term]
 id: CHEBI:33720
@@ -1718,12 +1787,14 @@ name: carbohydrate acid
 is_a: CHEBI:16646 ! carbohydrate
 is_a: CHEBI:33575 ! carboxylic acid
 relationship: is_conjugate_acid_of CHEBI:33721 ! carbohydrate acid anion
+relationship: RO:0018034 CHEBI:33721 ! is protonated form of carbohydrate acid anion
 
 [Term]
 id: CHEBI:33721
 name: carbohydrate acid anion
 is_a: CHEBI:29067 ! carboxylic acid anion
 relationship: is_conjugate_base_of CHEBI:33720 ! carbohydrate acid
+relationship: RO:0018033 CHEBI:33720 ! is deprotonated form of carbohydrate acid
 
 [Term]
 id: CHEBI:33791
@@ -1804,6 +1875,7 @@ def: "An ammonium ion that is the conjugate acid of serotonin; major species at
 is_a: CHEBI:35274 ! ammonium ion derivative
 relationship: is_conjugate_acid_of CHEBI:28790 ! serotonin
 relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
+relationship: RO:0018034 CHEBI:28790 ! is protonated form of serotonin
 
 [Term]
 id: CHEBI:35106
@@ -1814,7 +1886,7 @@ is_a: CHEBI:51143 ! nitrogen molecular entity
 [Term]
 id: CHEBI:35107
 name: azane
-def: "Saturated acyclic nitrogen hydrides having the general formula NnHn+2." []
+def: "Saturated acyclic nitrogen hydrides having the general formula N<small><sub><em>n</em></sub></small>H<small><sub><em>n</em>+2</sub></small>." []
 is_a: CHEBI:35106 ! nitrogen hydride
 
 [Term]
@@ -1849,6 +1921,7 @@ def: "A derivative of ammonium, NH4(+), in which one (or more) of the hydrogens
 is_a: CHEBI:33702 ! polyatomic cation
 is_a: CHEBI:51143 ! nitrogen molecular entity
 relationship: has_parent_hydride CHEBI:28938 ! ammonium
+relationship: RO:0018040 CHEBI:28938 ! has parent hydride ammonium
 
 [Term]
 id: CHEBI:35287
@@ -1859,7 +1932,7 @@ is_a: CHEBI:35267 ! quaternary ammonium ion
 [Term]
 id: CHEBI:35341
 name: steroid
-def: "Any of naturally occurring compounds and synthetic analogues, based on the cyclopenta[a]phenanthrene carbon skeleton, partially or completely hydrogenated; there are usually methyl groups at C-10 and C-13, and often an alkyl group at C-17. By extension, one or more bond scissions, ring expansions and/or ring contractions of the skeleton may have occurred. Natural steroids are derived biogenetically from squalene which is a triterpene." []
+def: "Any of naturally occurring compounds and synthetic analogues, based on the cyclopenta[<em>a</em>]phenanthrene carbon skeleton, partially or completely hydrogenated; there are usually methyl groups at C-10 and C-13, and often an alkyl group at C-17. By extension, one or more bond scissions, ring expansions and/or ring contractions of the skeleton may have occurred. Natural steroids are derived biogenetically from squalene which is a triterpene." []
 is_a: CHEBI:18059 ! lipid
 is_a: CHEBI:51958 ! organic polycyclic compound
 
@@ -1882,12 +1955,12 @@ name: fatty acid
 def: "Any aliphatic monocarboxylic acid derived from or contained in esterified form in an animal or vegetable fat, oil or wax. Natural fatty acids commonly have a chain of 4 to 28 carbons (usually unbranched and even-numbered), which may be saturated or unsaturated. By extension, the term is sometimes used to embrace all acyclic aliphatic carboxylic acids." []
 is_a: CHEBI:18059 ! lipid
 is_a: CHEBI:25384 ! monocarboxylic acid
-relationship: is_conjugate_acid_of CHEBI:28868 ! fatty acid anion
+relationship: RO:0018034 CHEBI:28868 ! is protonated form of fatty acid anion
 
 [Term]
 id: CHEBI:35381
 name: monosaccharide
-def: "Parent monosaccharides are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H-[CHOH]n-C(=O)[CHOH]m-H with three or more carbon atoms. The generic term 'monosaccharide' (as opposed to oligosaccharide or polysaccharide) denotes a single unit, without glycosidic connection to other such units. It includes aldoses, dialdoses, aldoketoses, ketoses and diketoses, as well as deoxy sugars, provided that the parent compound has a (potential) carbonyl group." []
+def: "Parent monosaccharides are polyhydroxy aldehydes H[CH(OH)]<small><sub><em>n</em></sub></small>C(=O)H or polyhydroxy ketones H‒[CHOH]<small><sub><em>n</em></sub></small>‒C(=O)[CHOH]<small><sub><em>m</em></sub></small>‒H with three or more carbon atoms. The generic term 'monosaccharide' (as opposed to oligosaccharide or polysaccharide) denotes a single unit, without glycosidic connection to other such units. It includes aldoses, dialdoses, aldoketoses, ketoses and diketoses, as well as deoxy sugars, provided that the parent compound has a (potential) carbonyl group." []
 is_a: CHEBI:16646 ! carbohydrate
 
 [Term]
@@ -1941,14 +2014,14 @@ is_a: CHEBI:23888 ! drug
 [Term]
 id: CHEBI:35569
 name: alpha-adrenergic agonist
-def: "An agent that selectively binds to and activates alpha-adrenergic receptors." []
+def: "An agent that selectively binds to and activates α-adrenergic receptors." []
 is_a: CHEBI:37886 ! adrenergic agonist
 is_a: CHEBI:48539 ! alpha-adrenergic drug
 
 [Term]
 id: CHEBI:35604
 name: carbon oxoanion
-def: "A negative ion consisting solely of carbon and oxygen  atoms, and therefore having the general formula CxOy(n-) for some integers x, y and n." []
+def: "A negative ion consisting solely of carbon and oxygen  atoms, and therefore having the general formula C<small><sub><em>x</em></sub></small>O<small><sub><em>y</em></sub></small><small><sup><em>n</em>−</small></sup> for some integers <em>x</em>, <em>y</em> and <em>n</em>." []
 is_a: CHEBI:25696 ! organic anion
 is_a: CHEBI:35406 ! oxoanion
 is_a: CHEBI:36963 ! organooxygen compound
@@ -1971,18 +2044,18 @@ name: dicarboxylic acid
 def: "Any carboxylic acid containing two carboxy groups." []
 is_a: CHEBI:131927 ! dicarboxylic acids and O-substituted derivatives
 is_a: CHEBI:33575 ! carboxylic acid
-relationship: is_conjugate_acid_of CHEBI:35693 ! dicarboxylic acid anion
+relationship: RO:0018034 CHEBI:35693 ! is protonated form of dicarboxylic acid anion
 
 [Term]
 id: CHEBI:35693
 name: dicarboxylic acid anion
 is_a: CHEBI:29067 ! carboxylic acid anion
-relationship: is_conjugate_base_of CHEBI:35692 ! dicarboxylic acid
+relationship: RO:0018033 CHEBI:35692 ! is deprotonated form of dicarboxylic acid
 
 [Term]
 id: CHEBI:35701
 name: ester
-def: "A compound formally derived from an oxoacid RkE(=O)l(OH)m (l > 0) and an alcohol, phenol, heteroarenol, or enol by linking with formal loss of water from an acidic hydroxy group of the former and a hydroxy group of the latter." []
+def: "A compound formally derived from an oxoacid R<small><sub><em>k</em></sub></small>E(=O)<small><sub><em>l</em></sub></small>(OH)<small><sub><em>m</em></sub></small> (<em>l</em> > 0) and an alcohol, phenol, heteroarenol, or enol by linking with formal loss of water from an acidic hydroxy group of the former and a hydroxy group of the latter." []
 is_a: CHEBI:36963 ! organooxygen compound
 
 [Term]
@@ -2004,6 +2077,7 @@ name: monocarboxylic acid anion
 def: "A carboxylic acid anion formed when the carboxy group of a monocarboxylic acid is deprotonated." []
 is_a: CHEBI:29067 ! carboxylic acid anion
 relationship: is_conjugate_base_of CHEBI:25384 ! monocarboxylic acid
+relationship: RO:0018033 CHEBI:25384 ! is deprotonated form of monocarboxylic acid
 
 [Term]
 id: CHEBI:35881
@@ -2022,7 +2096,7 @@ is_a: CHEBI:52210 ! pharmacological role
 id: CHEBI:36078
 name: cholanoid
 is_a: CHEBI:35341 ! steroid
-relationship: has_parent_hydride CHEBI:35519 ! cholane
+relationship: RO:0018040 CHEBI:35519 ! has parent hydride cholane
 
 [Term]
 id: CHEBI:36080
@@ -2056,10 +2130,10 @@ is_a: CHEBI:36248 ! 5beta-cholanic acids
 [Term]
 id: CHEBI:36248
 name: 5beta-cholanic acids
-def: "Members of the class of cholanic acids based on a 5beta-cholane skeleton." []
+def: "Members of the class of cholanic acids based on a 5β-cholane skeleton." []
 is_a: CHEBI:136889 ! 5beta steroid
 is_a: CHEBI:36278 ! cholanic acids
-relationship: has_parent_hydride CHEBI:20664 ! 5beta-cholane
+relationship: RO:0018040 CHEBI:20664 ! has parent hydride 5beta-cholane
 
 [Term]
 id: CHEBI:36277
@@ -2209,6 +2283,7 @@ name: amino-acid anion
 is_a: CHEBI:29067 ! carboxylic acid anion
 is_a: CHEBI:35352 ! organonitrogen compound
 relationship: is_conjugate_base_of CHEBI:33709 ! amino acid
+relationship: RO:0018033 CHEBI:33709 ! is deprotonated form of amino acid
 
 [Term]
 id: CHEBI:37163
@@ -2274,6 +2349,7 @@ id: CHEBI:37826
 name: sulfuric acid derivative
 is_a: CHEBI:33424 ! sulfur oxoacid derivative
 relationship: has_functional_parent CHEBI:26836 ! sulfuric acid
+relationship: RO:0018038 CHEBI:26836 ! has functional parent sulfuric acid
 
 [Term]
 id: CHEBI:37838
@@ -2281,6 +2357,7 @@ name: carboacyl group
 def: "A carboacyl group is a group formed by loss of at least one OH from the carboxy group of a carboxylic acid." []
 is_a: CHEBI:22221 ! acyl group
 relationship: is_substituent_group_from CHEBI:33575 ! carboxylic acid
+relationship: RO:0018037 CHEBI:33575 ! is substitutent group from carboxylic acid
 
 [Term]
 id: CHEBI:37886
@@ -2387,18 +2464,18 @@ name: straight-chain saturated fatty acid
 def: "Any saturated fatty acid lacking a side-chain." []
 is_a: CHEBI:26607 ! saturated fatty acid
 is_a: CHEBI:59202 ! straight-chain fatty acid
-relationship: is_conjugate_acid_of CHEBI:58954 ! straight-chain saturated fatty acid anion
+relationship: RO:0018034 CHEBI:58954 ! is protonated form of straight-chain saturated fatty acid anion
 
 [Term]
 id: CHEBI:41609
 name: carbonate
 is_a: CHEBI:35604 ! carbon oxoanion
-relationship: is_conjugate_base_of CHEBI:17544 ! hydrogencarbonate
+relationship: RO:0018033 CHEBI:17544 ! is deprotonated form of hydrogencarbonate
 
 [Term]
 id: CHEBI:4167
 name: D-glucopyranose
-def: "A glucopyranose having D-configuration." []
+def: "A glucopyranose having <small>D</small>-configuration." []
 is_a: CHEBI:17634 ! D-glucose
 is_a: CHEBI:37661 ! glucopyranose
 relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
@@ -2409,7 +2486,7 @@ relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
 [Term]
 id: CHEBI:4194
 name: D-hexose
-def: "A hexose that has D-configuration at position 5." []
+def: "A hexose that has <small>D</small>-configuration at position 5." []
 is_a: CHEBI:18133 ! hexose
 
 [Term]
@@ -2423,6 +2500,8 @@ name: hydrogensulfate
 is_a: CHEBI:33482 ! sulfur oxoanion
 relationship: is_conjugate_acid_of CHEBI:16189 ! sulfate
 relationship: is_conjugate_base_of CHEBI:26836 ! sulfuric acid
+relationship: RO:0018033 CHEBI:26836 ! is deprotonated form of sulfuric acid
+relationship: RO:0018034 CHEBI:16189 ! is protonated form of sulfate
 
 [Term]
 id: CHEBI:46629
@@ -2447,6 +2526,7 @@ name: acetate ester
 def: "Any carboxylic ester where the carboxylic acid component is acetic acid." []
 is_a: CHEBI:33308 ! carboxylic ester
 relationship: has_functional_parent CHEBI:15366 ! acetic acid
+relationship: RO:0018038 CHEBI:15366 ! has functional parent acetic acid
 
 [Term]
 id: CHEBI:47891
@@ -2454,7 +2534,7 @@ name: steroid acid
 def: "Any steroid substituted by at least one carboxy group." []
 is_a: CHEBI:35341 ! steroid
 is_a: CHEBI:64709 ! organic acid
-relationship: is_conjugate_acid_of CHEBI:50160 ! steroid acid anion
+relationship: RO:0018034 CHEBI:50160 ! is protonated form of steroid acid anion
 
 [Term]
 id: CHEBI:48154
@@ -2478,7 +2558,7 @@ is_a: CHEBI:48354 ! polar solvent
 [Term]
 id: CHEBI:48539
 name: alpha-adrenergic drug
-def: "Any drug that acts on an alpha-adrenergic receptor." []
+def: "Any drug that acts on an α-adrenergic receptor." []
 is_a: CHEBI:37962 ! adrenergic agent
 
 [Term]
@@ -2502,13 +2582,14 @@ def: "A compound formally derived from ammonia by replacing one, two or three hy
 is_a: CHEBI:35352 ! organonitrogen compound
 relationship: has_parent_hydride CHEBI:16134 ! ammonia
 relationship: RO:0000087 CHEBI:39142 ! has role Bronsted base
+relationship: RO:0018040 CHEBI:16134 ! has parent hydride ammonia
 
 [Term]
 id: CHEBI:50160
 name: steroid acid anion
 def: "Any anion formed by loss of a proton from a steroid acid." []
 is_a: CHEBI:29067 ! carboxylic acid anion
-relationship: is_conjugate_base_of CHEBI:47891 ! steroid acid
+relationship: RO:0018033 CHEBI:47891 ! is deprotonated form of steroid acid
 
 [Term]
 id: CHEBI:50297
@@ -2589,6 +2670,7 @@ name: primary amino compound
 def: "A compound formally derived from ammonia by replacing one hydrogen atom by an organyl group." []
 is_a: CHEBI:50047 ! organic amino compound
 relationship: is_conjugate_base_of CHEBI:65296 ! primary ammonium ion
+relationship: RO:0018033 CHEBI:65296 ! is deprotonated form of primary ammonium ion
 
 [Term]
 id: CHEBI:51086
@@ -2651,6 +2733,7 @@ is_a: CHEBI:24432 ! biological role
 [Term]
 id: CHEBI:52211
 name: physiological role
+def: "A biological role relating to the normal mechanisms and their interactions within a living system." []
 is_a: CHEBI:24432 ! biological role
 
 [Term]
@@ -2704,6 +2787,7 @@ relationship: is_conjugate_acid_of CHEBI:16765 ! tryptamine
 relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
 relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite
 relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
+relationship: RO:0018034 CHEBI:16765 ! is protonated form of tryptamine
 
 [Term]
 id: CHEBI:57977
@@ -2711,8 +2795,8 @@ name: bilirubin(2-)
 def: "A dicarboxylic acid dianion obtained by deprotonation of the two carboxy groups of bilirubin; major species at pH 7.3." []
 is_a: CHEBI:28965 ! dicarboxylic acid dianion
 is_a: CHEBI:59252 ! linear tetrapyrrole anion
-relationship: is_conjugate_base_of CHEBI:16990 ! bilirubin IXalpha
 relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
+relationship: RO:0018033 CHEBI:16990 ! is deprotonated form of bilirubin IXalpha
 
 [Term]
 id: CHEBI:58942
@@ -2720,18 +2804,19 @@ name: cationic amino-acid residue
 def: "An amino-acid residue protonated on nitrogen." []
 is_a: CHEBI:64769 ! organic cationic group
 relationship: is_conjugate_acid_of CHEBI:33708 ! amino-acid residue
+relationship: RO:0018034 CHEBI:33708 ! is protonated form of amino-acid residue
 
 [Term]
 id: CHEBI:58951
 name: short-chain fatty acid anion
-def: "Any fatty acid anion obtained by removal of a proton from the carboxy group of a short-chain fatty acid (chain length of less than C6)." []
+def: "Any fatty acid anion obtained by removal of a proton from the carboxy group of a short-chain fatty acid (chain length of less than C<small><sub>6</sub></small>)." []
 is_a: CHEBI:28868 ! fatty acid anion
-relationship: is_conjugate_base_of CHEBI:26666 ! short-chain fatty acid
+relationship: RO:0018033 CHEBI:26666 ! is deprotonated form of short-chain fatty acid
 
 [Term]
 id: CHEBI:58953
 name: saturated fatty acid anion
-def: "Any fatty acid anion in which there is no C-C unsaturation." []
+def: "Any fatty acid anion in which there is no C‒C unsaturation." []
 is_a: CHEBI:28868 ! fatty acid anion
 
 [Term]
@@ -2739,7 +2824,7 @@ id: CHEBI:58954
 name: straight-chain saturated fatty acid anion
 def: "Any saturated fatty acid anion lacking a carbon side-chain." []
 is_a: CHEBI:58953 ! saturated fatty acid anion
-relationship: is_conjugate_base_of CHEBI:39418 ! straight-chain saturated fatty acid
+relationship: RO:0018033 CHEBI:39418 ! is deprotonated form of straight-chain saturated fatty acid
 
 [Term]
 id: CHEBI:58958
@@ -2749,20 +2834,22 @@ is_a: CHEBI:25696 ! organic anion
 is_a: CHEBI:33482 ! sulfur oxoanion
 relationship: has_functional_parent CHEBI:16189 ! sulfate
 relationship: is_conjugate_base_of CHEBI:25704 ! organic sulfate
+relationship: RO:0018033 CHEBI:25704 ! is deprotonated form of organic sulfate
+relationship: RO:0018038 CHEBI:16189 ! has functional parent sulfate
 
 [Term]
 id: CHEBI:59202
 name: straight-chain fatty acid
 def: "Any fatty acid whose skeletal carbon atoms form an unbranched open chain." []
 is_a: CHEBI:35366 ! fatty acid
-relationship: is_conjugate_acid_of CHEBI:59203 ! straight-chain fatty acid anion
+relationship: RO:0018034 CHEBI:59203 ! is protonated form of straight-chain fatty acid anion
 
 [Term]
 id: CHEBI:59203
 name: straight-chain fatty acid anion
 def: "A fatty acid anion formed by deprotonation of the carboxylic acid functional group of a straight-chain fatty acid." []
 is_a: CHEBI:28868 ! fatty acid anion
-relationship: is_conjugate_base_of CHEBI:59202 ! straight-chain fatty acid
+relationship: RO:0018033 CHEBI:59202 ! is deprotonated form of straight-chain fatty acid
 
 [Term]
 id: CHEBI:59252
@@ -2780,30 +2867,30 @@ is_a: CHEBI:39144 ! Lewis base
 [Term]
 id: CHEBI:59814
 name: L-alpha-amino acid anion
-def: "Conjugate base of an L-alpha-amino acid arising from deprotonation of the C-1 carboxy group." []
+def: "Conjugate base of an <small>L</small>-α-amino acid arising from deprotonation of the C-1 carboxy group." []
 is_a: CHEBI:33558 ! alpha-amino-acid anion
-relationship: is_conjugate_base_of CHEBI:15705 ! L-alpha-amino acid
+relationship: RO:0018033 CHEBI:15705 ! is deprotonated form of L-alpha-amino acid
 
 [Term]
 id: CHEBI:59869
 name: L-alpha-amino acid zwitterion
-def: "Zwitterionic form of an L-alpha-amino acid having an anionic carboxy group and a protonated amino group." []
+def: "Zwitterionic form of an <small>L</small>-α-amino acid having an anionic carboxy group and a protonated amino group." []
 is_a: CHEBI:78608 ! alpha-amino-acid zwitterion
-relationship: is_tautomer_of CHEBI:15705 ! L-alpha-amino acid
+relationship: RO:0018036 CHEBI:15705 ! is tautomer of L-alpha-amino acid
 
 [Term]
 id: CHEBI:59871
 name: D-alpha-amino acid zwitterion
-def: "Zwitterionic form of a D-alpha-amino acid having an anionic carboxy group and a protonated amino group." []
+def: "Zwitterionic form of a <small>D</small>-α-amino acid having an anionic carboxy group and a protonated amino group." []
 is_a: CHEBI:35238 ! amino-acid zwitterion
-relationship: is_tautomer_of CHEBI:16733 ! D-alpha-amino acid
+relationship: RO:0018036 CHEBI:16733 ! is tautomer of D-alpha-amino acid
 
 [Term]
 id: CHEBI:59888
 name: gamma-aminobutyric acid zwitterion
-def: "Zwitterionic form of gamma-aminobutyric acid having an anionic carboxy group and a protonated amino group." []
+def: "Zwitterionic form of γ-aminobutyric acid having an anionic carboxy group and a protonated amino group." []
 is_a: CHEBI:35238 ! amino-acid zwitterion
-relationship: is_tautomer_of CHEBI:16865 ! gamma-aminobutyric acid
+relationship: RO:0018036 CHEBI:16865 ! is tautomer of gamma-aminobutyric acid
 
 [Term]
 id: CHEBI:59999
@@ -2843,13 +2930,14 @@ name: peptide zwitterion
 def: "Zwitterionic form of any peptide where, in general, the amino terminus is positively charged and the carboxy terminus is negatively charged." []
 is_a: CHEBI:27369 ! zwitterion
 relationship: is_tautomer_of CHEBI:16670 ! peptide
+relationship: RO:0018036 CHEBI:16670 ! is tautomer of peptide
 
 [Term]
 id: CHEBI:60895
 name: D-alpha-amino acid anion
-def: "Any alpha-amino acid anion in which the parent amino acid has D-configuration." []
+def: "Any α-amino acid anion in which the parent amino acid has <small>D</small>-configuration." []
 is_a: CHEBI:33558 ! alpha-amino-acid anion
-relationship: is_conjugate_base_of CHEBI:16733 ! D-alpha-amino acid
+relationship: RO:0018033 CHEBI:16733 ! is deprotonated form of D-alpha-amino acid
 
 [Term]
 id: CHEBI:61115
@@ -2864,6 +2952,7 @@ def: "Any compound that has a nucleobase as a part." []
 is_a: CHEBI:33833 ! heteroarene
 is_a: CHEBI:51143 ! nitrogen molecular entity
 relationship: has_functional_parent CHEBI:18282 ! nucleobase
+relationship: RO:0018038 CHEBI:18282 ! has functional parent nucleobase
 
 [Term]
 id: CHEBI:61469
@@ -2877,7 +2966,7 @@ id: CHEBI:62031
 name: polar amino acid zwitterion
 def: "Zwitterionic form of a polar amino acid having an anionic carboxy group and a protonated amino group." []
 is_a: CHEBI:35238 ! amino-acid zwitterion
-relationship: is_tautomer_of CHEBI:26167 ! polar amino acid
+relationship: RO:0018036 CHEBI:26167 ! is tautomer of polar amino acid
 
 [Term]
 id: CHEBI:62488
@@ -2897,6 +2986,7 @@ name: carbohydrate derivative
 def: "Any organooxygen compound derived from a carbohydrate by replacement of one or more hydroxy group(s) by an amino group, a thiol group or similar heteroatomic groups. The term also includes derivatives of these compounds." []
 is_a: CHEBI:78616 ! carbohydrates and carbohydrate derivatives
 relationship: has_functional_parent CHEBI:16646 ! carbohydrate
+relationship: RO:0018038 CHEBI:16646 ! has functional parent carbohydrate
 
 [Term]
 id: CHEBI:63436
@@ -2905,6 +2995,8 @@ def: "A carbohydrate derivative that is formally obtained from a carbohydrate ac
 is_a: CHEBI:63299 ! carbohydrate derivative
 relationship: has_functional_parent CHEBI:33720 ! carbohydrate acid
 relationship: is_conjugate_acid_of CHEBI:63551 ! carbohydrate acid derivative anion
+relationship: RO:0018034 CHEBI:63551 ! is protonated form of carbohydrate acid derivative anion
+relationship: RO:0018038 CHEBI:33720 ! has functional parent carbohydrate acid
 
 [Term]
 id: CHEBI:63534
@@ -2919,6 +3011,8 @@ def: "A carboxylic acid anion resulting from the deprotonation of the carboxy gr
 is_a: CHEBI:29067 ! carboxylic acid anion
 relationship: has_functional_parent CHEBI:33721 ! carbohydrate acid anion
 relationship: is_conjugate_base_of CHEBI:63436 ! carbohydrate acid derivative
+relationship: RO:0018033 CHEBI:63436 ! is deprotonated form of carbohydrate acid derivative
+relationship: RO:0018038 CHEBI:33721 ! has functional parent carbohydrate acid anion
 
 [Term]
 id: CHEBI:64047
@@ -2976,6 +3070,7 @@ name: organic cationic group
 def: "A cationic group that contains carbon." []
 is_a: CHEBI:64766 ! cationic group
 relationship: is_conjugate_acid_of CHEBI:33247 ! organic group
+relationship: RO:0018034 CHEBI:33247 ! is protonated form of organic group
 
 [Term]
 id: CHEBI:64775
@@ -2983,6 +3078,7 @@ name: organic anionic group
 def: "An anionic group that contains carbon." []
 is_a: CHEBI:64767 ! anionic group
 relationship: is_conjugate_base_of CHEBI:33247 ! organic group
+relationship: RO:0018033 CHEBI:33247 ! is deprotonated form of organic group
 
 [Term]
 id: CHEBI:64898
@@ -2990,6 +3086,7 @@ name: anionic amino-acid residue
 def: "An amino-acid residue carrying an overall negative charge." []
 is_a: CHEBI:64775 ! organic anionic group
 relationship: is_conjugate_base_of CHEBI:33708 ! amino-acid residue
+relationship: RO:0018033 CHEBI:33708 ! is deprotonated form of amino-acid residue
 
 [Term]
 id: CHEBI:64909
@@ -3005,6 +3102,7 @@ is_a: CHEBI:167559 ! glycan
 is_a: CHEBI:33694 ! biomacromolecule
 is_a: CHEBI:63299 ! carbohydrate derivative
 relationship: has_functional_parent CHEBI:18154 ! polysaccharide
+relationship: RO:0018038 CHEBI:18154 ! has functional parent polysaccharide
 
 [Term]
 id: CHEBI:65255
@@ -3026,6 +3124,7 @@ def: "An ammonium ion derivative resulting from the protonation of the nitrogen
 is_a: CHEBI:25697 ! organic cation
 is_a: CHEBI:35274 ! ammonium ion derivative
 relationship: is_conjugate_acid_of CHEBI:50994 ! primary amino compound
+relationship: RO:0018034 CHEBI:50994 ! is protonated form of primary amino compound
 
 [Term]
 id: CHEBI:67079
@@ -3036,17 +3135,18 @@ is_a: CHEBI:33232 ! application
 [Term]
 id: CHEBI:71666
 name: gamma-amino acid anion
-def: "An amino-acid anion in which the amino group is situated gamma- to the carboxylate group." []
+def: "An amino-acid anion in which the amino group is situated γ- to the carboxylate group." []
 is_a: CHEBI:37022 ! amino-acid anion
-relationship: is_conjugate_base_of CHEBI:33707 ! gamma-amino acid
+relationship: RO:0018033 CHEBI:33707 ! is deprotonated form of gamma-amino acid
 
 [Term]
 id: CHEBI:72587
 name: (R)-noradrenaline(1+)
-def: "An organic cation that is the conjugate acid of (R)-noradrenaline, obtained by protonation of the priamry amino group; major species at pH 7.3." []
+def: "An organic cation that is the conjugate acid of (<i>R</i>)-noradrenaline, obtained by protonation of the primary amino group; major species at pH 7.3." []
 is_a: CHEBI:166902 ! noradrenaline(1+)
-relationship: is_conjugate_acid_of CHEBI:18357 ! (R)-noradrenaline
 relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
+relationship: RO:0018034 CHEBI:18357 ! is protonated form of (R)-noradrenaline
+relationship: RO:0018039 CHEBI:234420 ! is enantiomer of (S)-noradrenaline(1+)
 
 [Term]
 id: CHEBI:72695
@@ -3076,7 +3176,7 @@ is_a: CHEBI:52845 ! cyclic organic group
 [Term]
 id: CHEBI:75600
 name: EC 6.3.* (C-N bond-forming ligase) inhibitor
-def: "A ligase inhibitor that interferes with the action of a C-N bond-forming ligase (EC 6.3.*.*)." []
+def: "A ligase inhibitor that interferes with the action of a <em>C</em>‒<em>N</em> bond-forming ligase (EC 6.3.*.*)." []
 is_a: CHEBI:75603 ! EC 6.* (ligase) inhibitor
 
 [Term]
@@ -3106,13 +3206,13 @@ is_a: CHEBI:75767 ! animal metabolite
 [Term]
 id: CHEBI:75771
 name: mouse metabolite
-def: "Any mammalian metabolite produced during a metabolic reaction in a mouse (Mus musculus)." []
+def: "Any mammalian metabolite produced during a metabolic reaction in a mouse (<em>Mus musculus</em>)." []
 is_a: CHEBI:75768 ! mammalian metabolite
 
 [Term]
 id: CHEBI:75772
 name: Saccharomyces cerevisiae metabolite
-def: "Any  fungal metabolite produced during a metabolic reaction in Baker's yeast (Saccharomyces cerevisiae)." []
+def: "Any  fungal metabolite produced during a metabolic reaction in Baker's yeast (<em>Saccharomyces cerevisiae </em>)." []
 is_a: CHEBI:76946 ! fungal metabolite
 
 [Term]
@@ -3148,7 +3248,7 @@ is_a: CHEBI:76764 ! EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibi
 [Term]
 id: CHEBI:76823
 name: EC 6.3.1.* (acid-ammonia/amine ligase) inhibitor
-def: "An EC 6.3.* (C-N bond-forming ligase) inhibitor that interferes with the action of any acid-ammonia (or amine) ligase (EC 6.3.1.*)." []
+def: "An EC 6.3.* (<em>C</em>‒<em>N</em> bond-forming ligase) inhibitor that interferes with the action of any acid-ammonia (or amine) ligase (EC 6.3.1.*)." []
 is_a: CHEBI:75600 ! EC 6.3.* (C-N bond-forming ligase) inhibitor
 
 [Term]
@@ -3179,13 +3279,13 @@ is_a: CHEBI:75787 ! prokaryotic metabolite
 [Term]
 id: CHEBI:76971
 name: Escherichia coli metabolite
-def: "Any bacterial metabolite produced during a metabolic reaction in Escherichia coli." []
+def: "Any bacterial metabolite produced during a metabolic reaction in <em>Escherichia coli</em>." []
 is_a: CHEBI:76969 ! bacterial metabolite
 
 [Term]
 id: CHEBI:77746
 name: human metabolite
-def: "Any mammalian metabolite  produced during a metabolic reaction in humans (Homo sapiens)." []
+def: "Any mammalian metabolite  produced during a metabolic reaction in humans (<em>Homo sapiens</em>)." []
 is_a: CHEBI:75768 ! mammalian metabolite
 
 [Term]
@@ -3206,7 +3306,7 @@ name: fatty acid anion 4:0
 def: "Any saturated fatty acid anion containing 4 carbons. Formed by deprotonation of the carboxylic acid moiety. Major species at pH 7.3." []
 is_a: CHEBI:58951 ! short-chain fatty acid anion
 is_a: CHEBI:58953 ! saturated fatty acid anion
-relationship: is_conjugate_base_of CHEBI:140601 ! fatty acid 4:0
+relationship: RO:0018033 CHEBI:140601 ! is deprotonated form of fatty acid 4:0
 
 [Term]
 id: CHEBI:78295
@@ -3226,11 +3326,12 @@ name: alpha-amino-acid zwitterion
 def: "An amino acid-zwitterion obtained by transfer of a proton from the carboxy to the amino group of any alpha-amino acid; major species at pH 7.3." []
 is_a: CHEBI:35238 ! amino-acid zwitterion
 relationship: is_tautomer_of CHEBI:33704 ! alpha-amino acid
+relationship: RO:0018036 CHEBI:33704 ! is tautomer of alpha-amino acid
 
 [Term]
 id: CHEBI:78616
 name: carbohydrates and carbohydrate derivatives
-def: "Any organooxygen compound that is a polyhydroxy-aldehyde or -ketone, or a compound derived from one. Carbohydrates contain only carbon, hydrogen and oxygen and usually have an empirical formula Cm(H2O)n; carbohydrate derivatives may contain other elements by substitution or condensation." []
+def: "Any organooxygen compound that is a polyhydroxy-aldehyde or -ketone, or a compound derived from one. Carbohydrates contain only carbon, hydrogen and oxygen and usually have an empirical formula C<small><sub><em>m</em></sub></small>(H<small><sub>2</sub></small>O)<small><sub><em>n</em></sub></small>; carbohydrate derivatives may contain other elements by substitution or condensation." []
 is_a: CHEBI:36963 ! organooxygen compound
 
 [Term]
@@ -3260,19 +3361,19 @@ is_a: CHEBI:75767 ! animal metabolite
 [Term]
 id: CHEBI:83056
 name: Daphnia magna metabolite
-def: "A Daphnia metabolite produced by the species Daphnia magna." []
+def: "A <em>Daphnia</em> metabolite produced by the species <em>Daphnia magna</em>." []
 is_a: CHEBI:83057 ! Daphnia metabolite
 
 [Term]
 id: CHEBI:83057
 name: Daphnia metabolite
-def: "A crustacean metabolite produced by the genus of small planktonic arthropods, Daphnia" []
+def: "A crustacean metabolite produced by the genus of small planktonic arthropods, <em>Daphnia</em>" []
 is_a: CHEBI:83039 ! crustacean metabolite
 
 [Term]
 id: CHEBI:83813
 name: proteinogenic amino acid
-def: "Any of the 23 alpha-amino acids that are precursors to proteins, and are incorporated into proteins during translation. The group includes the 20 amino acids encoded by the nuclear genes of eukaryotes together with selenocysteine, pyrrolysine, and N-formylmethionine. Apart from glycine, which is non-chiral, all have L configuration." []
+def: "Any of the 23 α-amino acids that are precursors to proteins, and are incorporated into proteins during translation. The group includes the 20 amino acids encoded by the nuclear genes of eukaryotes together with selenocysteine, pyrrolysine, and <em>N</em>-formylmethionine. Apart from glycine, which is non-chiral, all have <small>L</small> configuration." []
 is_a: CHEBI:33709 ! amino acid
 
 [Term]
@@ -3284,7 +3385,7 @@ is_a: CHEBI:33709 ! amino acid
 [Term]
 id: CHEBI:83925
 name: non-proteinogenic alpha-amino acid
-def: "Any  alpha-amino acid which is not a member of the group of 23 proteinogenic amino acids." []
+def: "Any  α-amino acid which is not a member of the group of 23 proteinogenic amino acids." []
 is_a: CHEBI:33704 ! alpha-amino acid
 is_a: CHEBI:83820 ! non-proteinogenic amino acid
 
@@ -3309,9 +3410,10 @@ is_a: UBERON:0000061 ! anatomical structure
 disjoint_from: GO:0031012 ! extracellular matrix
 disjoint_from: GO:0032991 ! protein-containing complex
 disjoint_from: GO:0043226 ! organelle
+disjoint_from: GO:0044423 ! virion component
 relationship: BFO:0000051 GO:0005634 {gci_filler="PATO:0001407", gci_relation="RO:0000053"} ! has part nucleus
 relationship: BFO:0000051 GO:0005634 {gci_filler="PATO:0001908", gci_relation="RO:0000053"} ! has part nucleus
-relationship: RO:0002162 NCBITaxon:131567 ! in taxon cellular organisms
+relationship: RO:0002162 NCBITaxon:131567 ! in taxon cellular organism
 
 [Term]
 id: CL:0000005
@@ -3973,6 +4075,7 @@ name: chondrocyte
 synonym: "cartilage cell" EXACT []
 is_a: CL:0000153 ! glycosaminoglycan secreting cell
 is_a: CL:0000667 ! collagen secreting cell
+is_a: CL:0007001 ! skeletogenic cell
 relationship: RO:0001025 UBERON:0002418 ! located in cartilage tissue
 relationship: RO:0002202 CL:0000058 ! develops from chondroblast
 
@@ -8864,298 +8967,298 @@ is_a: EMPTY:0000002 ! behavioral measurement
 [Term]
 id: EMPTY:0000006
 name: elevated plus maze: open arm (north) - entries
-def: "In the Elevated Plus Maze task, this counts the number of times the animal's body (typically defined by its center point or a significant portion) fully enters the user-defined zone designated as 'Open Arm (North)'. The 'Open Arm (North)' is one of the two open arms, distinguished by its assigned 'north' orientation or designation in the experimental setup. Unit of measure: count" []
+def: "In the Elevated Plus Maze task, this counts the number of times the animal's body (typically defined by its center point or a significant portion) fully enters the user-defined zone designated as 'Open Arm (North)'. The 'Open Arm (North)' is one of the two open arms, distinguished by its assigned 'north' orientation or designation in the experimental setup. Unit: count" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 
 [Term]
 id: EMPTY:0000007
 name: elevated plus maze: open arm (south) - entries
-def: "In the Elevated Plus Maze task, this counts the number of times the animal's body (typically defined by its center point or a significant portion) fully enters the user-defined zone designated as 'Open Arm (South)'. The 'Open Arm (South)' is one of the two open arms, distinguished by its assigned 'south' orientation or designation in the experimental setup. Unit of measure: count" []
+def: "In the Elevated Plus Maze task, this counts the number of times the animal's body (typically defined by its center point or a significant portion) fully enters the user-defined zone designated as 'Open Arm (South)'. The 'Open Arm (South)' is one of the two open arms, distinguished by its assigned 'south' orientation or designation in the experimental setup. Unit: count" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 
 [Term]
 id: EMPTY:0000008
 name: elevated plus maze: open arm total entries
-def: "In the Elevated Plus Maze task, this represents the total number of times the animal's body (typically defined by its center point or a significant portion) fully enters the designated open arm zones (e.g., 'Open Arm (North)' and 'Open Arm (South)'). It is a common measure of exploration and anxiety. Unit of measure: count" []
+def: "In the Elevated Plus Maze task, this represents the total number of times the animal's body (typically defined by its center point or a significant portion) fully enters the designated open arm zones (e.g., 'Open Arm (North)' and 'Open Arm (South)'). It is a common measure of exploration and anxiety. Unit: count" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 
 [Term]
 id: EMPTY:0000009
 name: elevated plus maze: open arm (north) - head entries
-def: "In the Elevated Plus Maze task, this counts the number of times the animal's head (specifically tracked by the software) enters the user-defined 'Open Arm (North)' zone, irrespective of full body entry. This can indicate risk assessment or tentative exploration of the arm designated as 'north'. Unit of measure: count" []
+def: "In the Elevated Plus Maze task, this counts the number of times the animal's head (specifically tracked by the software) enters the user-defined 'Open Arm (North)' zone, irrespective of full body entry. This can indicate risk assessment or tentative exploration of the arm designated as 'north'. Unit: count" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 
 [Term]
 id: EMPTY:0000010
 name: elevated plus maze: open arm (south) - head entries
-def: "In the Elevated Plus Maze task, this counts the number of times the animal's head (specifically tracked by the software) enters the user-defined 'Open Arm (South)' zone, irrespective of full body entry, often reflecting cautious exploration of the open arm designated as 'south'. Unit of measure: count" []
+def: "In the Elevated Plus Maze task, this counts the number of times the animal's head (specifically tracked by the software) enters the user-defined 'Open Arm (South)' zone, irrespective of full body entry, often reflecting cautious exploration of the open arm designated as 'south'. Unit: count" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 
 [Term]
 id: EMPTY:0000011
 name: elevated plus maze: open arm total head entries
-def: "In the Elevated Plus Maze task, this is the total number of times the animal's head (specifically tracked by the software) enters any of the designated open arm zones (e.g., 'Open Arm (North)' and 'Open Arm (South)'), considered an indicator of risk-assessment behavior. Unit of measure: count" []
+def: "In the Elevated Plus Maze task, this is the total number of times the animal's head (specifically tracked by the software) enters any of the designated open arm zones (e.g., 'Open Arm (North)' and 'Open Arm (South)'), considered an indicator of risk-assessment behavior. Unit: count" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 
 [Term]
 id: EMPTY:0000012
 name: elevated plus maze: open arm (north) - time
-def: "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Open Arm (North)' zone. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Open Arm (North)' zone. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000013
 name: elevated plus maze: open arm (south) - time
-def: "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Open Arm (South)' zone. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Open Arm (South)' zone. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000014
 name: elevated plus maze: open arm total time
-def: "In the Elevated Plus Maze task, this is the cumulative total duration the animal's body spends within any of the designated open arm zones (e.g., 'Open Arm (North)' and 'Open Arm (South)'). Less time is generally indicative of higher anxiety. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this is the cumulative total duration the animal's body spends within any of the designated open arm zones (e.g., 'Open Arm (North)' and 'Open Arm (South)'). Less time is generally indicative of higher anxiety. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000015
 name: elevated plus maze: open arm total - percent time during test duration
-def: "In the Elevated Plus Maze task, this represents the percentage of the total test duration that the animal spends in any of the designated open arm zones (e.g., 'Open Arm (North)' and 'Open Arm (South)'). Unit of measure: %" []
+def: "In the Elevated Plus Maze task, this represents the percentage of the total test duration that the animal spends in any of the designated open arm zones (e.g., 'Open Arm (North)' and 'Open Arm (South)'). Unit: %" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 
 [Term]
 id: EMPTY:0000016
 name: elevated plus maze: open arm (north) - latency to first entry
-def: "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Open Arm (North)' zone. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Open Arm (North)' zone. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000091 ! timepoint
 
 [Term]
 id: EMPTY:0000017
 name: elevated plus maze: open arm (south) - latency to first entry
-def: "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Open Arm (South)' zone. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Open Arm (South)' zone. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000091 ! timepoint
 
 [Term]
 id: EMPTY:0000018
 name: elevated plus maze: open arm total latency to first entry
-def: "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into any of the designated open arm zones (e.g., 'Open Arm (North)' or 'Open Arm (South)'). Longer latencies often suggest higher anxiety. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into any of the designated open arm zones (e.g., 'Open Arm (North)' or 'Open Arm (South)'). Longer latencies often suggest higher anxiety. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000091 ! timepoint
 
 [Term]
 id: EMPTY:0000019
 name: elevated plus maze: open arm (north) - time moving towards
-def: "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Open Arm (North)' zone, as detected by the tracking software. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Open Arm (North)' zone, as detected by the tracking software. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000020
 name: elevated plus maze: open arm (south) - time moving towards
-def: "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Open Arm (South)' zone, as detected by the tracking software. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Open Arm (South)' zone, as detected by the tracking software. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000021
 name: elevated plus maze: open arm total time moving towards
-def: "In the Elevated Plus Maze task, this is the cumulative duration the animal spends actively moving towards any of the designated open arm zones (e.g., 'Open Arm (North)' or 'Open Arm (South)'), reflecting approach motivation. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this is the cumulative duration the animal spends actively moving towards any of the designated open arm zones (e.g., 'Open Arm (North)' or 'Open Arm (South)'), reflecting approach motivation. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000022
 name: elevated plus maze: open arm (north) - time freezing
-def: "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior (a state of immobility except for respiratory movements) while within the user-defined 'Open Arm (North)' zone. Freezing is a common fear response. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior (a state of immobility except for respiratory movements) while within the user-defined 'Open Arm (North)' zone. Freezing is a common fear response. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000023
 name: elevated plus maze: open arm (south) - time freezing
-def: "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined 'Open Arm (South)' zone. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined 'Open Arm (South)' zone. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000024
 name: elevated plus maze: open arm total time freezing
-def: "In the Elevated Plus Maze task, this is the cumulative duration the animal exhibits freezing behavior while within any of the designated open arm zones (e.g., 'Open Arm (North)' or 'Open Arm (South)'), indicating fear or anxiety. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this is the cumulative duration the animal exhibits freezing behavior while within any of the designated open arm zones (e.g., 'Open Arm (North)' or 'Open Arm (South)'), indicating fear or anxiety. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000025
 name: elevated plus maze: closed arm (west) - entries
-def: "In the Elevated Plus Maze task, this counts the number of times the animal's body fully enters the user-defined 'Closed Arm (West)' zone, representing the enclosed arm designated as 'west'. Unit of measure: count" []
+def: "In the Elevated Plus Maze task, this counts the number of times the animal's body fully enters the user-defined 'Closed Arm (West)' zone, representing the enclosed arm designated as 'west'. Unit: count" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 
 [Term]
 id: EMPTY:0000026
 name: elevated plus maze: closed arm (east) - entries
-def: "In the Elevated Plus Maze task, this counts the number of times the animal's body fully enters the user-defined 'Closed Arm (East)' zone, representing the enclosed arm designated as 'east'. Unit of measure: count" []
+def: "In the Elevated Plus Maze task, this counts the number of times the animal's body fully enters the user-defined 'Closed Arm (East)' zone, representing the enclosed arm designated as 'east'. Unit: count" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 
 [Term]
 id: EMPTY:0000027
 name: elevated plus maze: closed arm total entries
-def: "In the Elevated Plus Maze task, this is the total number of times the animal's body fully enters any of the designated closed arm zones (e.g., 'Closed Arm (West)' and 'Closed Arm (East)'). It is often used as an indicator of general locomotor activity. Unit of measure: count" []
+def: "In the Elevated Plus Maze task, this is the total number of times the animal's body fully enters any of the designated closed arm zones (e.g., 'Closed Arm (West)' and 'Closed Arm (East)'). It is often used as an indicator of general locomotor activity. Unit: count" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 
 [Term]
 id: EMPTY:0000028
 name: elevated plus maze: closed arm (west) - head entries
-def: "In the Elevated Plus Maze task, this counts the number of times the animal's head enters the user-defined 'Closed Arm (West)' zone. Unit of measure: count" []
+def: "In the Elevated Plus Maze task, this counts the number of times the animal's head enters the user-defined 'Closed Arm (West)' zone. Unit: count" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 
 [Term]
 id: EMPTY:0000029
 name: elevated plus maze: closed arm (east) - head entries
-def: "In the Elevated Plus Maze task, this counts the number of times the animal's head enters the user-defined 'Closed Arm (East)' zone. Unit of measure: count" []
+def: "In the Elevated Plus Maze task, this counts the number of times the animal's head enters the user-defined 'Closed Arm (East)' zone. Unit: count" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 
 [Term]
 id: EMPTY:0000030
 name: elevated plus maze: closed arm total head entries
-def: "In the Elevated Plus Maze task, this is the total number of times the animal's head enters any of the designated closed arm zones (e.g., 'Closed Arm (West)' and 'Closed Arm (East)'). Unit of measure: count" []
+def: "In the Elevated Plus Maze task, this is the total number of times the animal's head enters any of the designated closed arm zones (e.g., 'Closed Arm (West)' and 'Closed Arm (East)'). Unit: count" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 
 [Term]
 id: EMPTY:0000031
 name: elevated plus maze: closed arm (west) - time
-def: "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Closed Arm (West)' zone. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Closed Arm (West)' zone. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000032
 name: elevated plus maze: closed arm (east) - time
-def: "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Closed Arm (East)' zone. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Closed Arm (East)' zone. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000033
 name: elevated plus maze: closed arm total time
-def: "In the Elevated Plus Maze task, this is the cumulative total duration the animal's body spends within any of the designated closed arm zones (e.g., 'Closed Arm (West)' and 'Closed Arm (East)'). Animals typically spend more time in these 'safer' areas. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this is the cumulative total duration the animal's body spends within any of the designated closed arm zones (e.g., 'Closed Arm (West)' and 'Closed Arm (East)'). Animals typically spend more time in these 'safer' areas. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000034
 name: elevated plus maze: closed arm total - percent time during test duration
-def: "In the Elevated Plus Maze task, this represents the percentage of the total test duration that the animal spends in any of the designated closed arm zones (e.g., 'Closed Arm (West)' and 'Closed Arm (East)'). Unit of measure: %" []
+def: "In the Elevated Plus Maze task, this represents the percentage of the total test duration that the animal spends in any of the designated closed arm zones (e.g., 'Closed Arm (West)' and 'Closed Arm (East)'). Unit: %" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 
 [Term]
 id: EMPTY:0000035
 name: elevated plus maze: closed arm (west) - latency to first entry
-def: "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Closed Arm (West)' zone. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Closed Arm (West)' zone. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000091 ! timepoint
 
 [Term]
 id: EMPTY:0000036
 name: elevated plus maze: closed arm (east) - latency to first entry
-def: "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Closed Arm (East)' zone. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Closed Arm (East)' zone. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000091 ! timepoint
 
 [Term]
 id: EMPTY:0000037
 name: elevated plus maze: closed arm total latency to first entry
-def: "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into any of the designated closed arm zones (e.g., 'Closed Arm (West)' or 'Closed Arm (East)'). Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into any of the designated closed arm zones (e.g., 'Closed Arm (West)' or 'Closed Arm (East)'). Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000091 ! timepoint
 
 [Term]
 id: EMPTY:0000038
 name: elevated plus maze: closed arm (west) - time moving towards
-def: "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Closed Arm (West)' zone. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Closed Arm (West)' zone. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000039
 name: elevated plus maze: closed arm (east) - time moving towards
-def: "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Closed Arm (East)' zone. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Closed Arm (East)' zone. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000040
 name: elevated plus maze: closed arm total time moving towards
-def: "In the Elevated Plus Maze task, this is the cumulative duration the animal spends actively moving towards any of the designated closed arm zones (e.g., 'Closed Arm (West)' or 'Closed Arm (East)'). Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this is the cumulative duration the animal spends actively moving towards any of the designated closed arm zones (e.g., 'Closed Arm (West)' or 'Closed Arm (East)'). Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000041
 name: elevated plus maze: closed arm (west) - time freezing
-def: "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined 'Closed Arm (West)' zone. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined 'Closed Arm (West)' zone. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000042
 name: elevated plus maze: closed arm (east) - time freezing
-def: "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined 'Closed Arm (East)' zone. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined 'Closed Arm (East)' zone. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000043
 name: elevated plus maze: closed arm total time freezing
-def: "In the Elevated Plus Maze task, this is the cumulative duration the animal exhibits freezing behavior while within any of the designated closed arm zones (e.g., 'Closed Arm (West)' or 'Closed Arm (East)'). Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this is the cumulative duration the animal exhibits freezing behavior while within any of the designated closed arm zones (e.g., 'Closed Arm (West)' or 'Closed Arm (East)'). Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000044
 name: elevated plus maze: center - entries
-def: "In the Elevated Plus Maze task, this counts the number of times the animal's body fully enters the user-defined 'Center' zone of the maze, typically from one of the arms. The center zone is the area where all four arms meet. Unit of measure: count" []
+def: "In the Elevated Plus Maze task, this counts the number of times the animal's body fully enters the user-defined 'Center' zone of the maze, typically from one of the arms. The center zone is the area where all four arms meet. Unit: count" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 
 [Term]
 id: EMPTY:0000045
 name: elevated plus maze: center - head entries
-def: "In the Elevated Plus Maze task, this counts the number of times the animal's head enters the user-defined 'Center' zone of the maze. Unit of measure: count" []
+def: "In the Elevated Plus Maze task, this counts the number of times the animal's head enters the user-defined 'Center' zone of the maze. Unit: count" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 
 [Term]
 id: EMPTY:0000046
 name: elevated plus maze: center - time
-def: "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Center' zone. Time in the center can indicate decision-making or risk assessment. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Center' zone. Time in the center can indicate decision-making or risk assessment. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000047
 name: elevated plus maze: center - percent time during test duration
-def: "In the Elevated Plus Maze task, this represents the percentage of the total test duration that the animal spends in the user-defined 'Center' zone of the maze. Unit of measure: %" []
+def: "In the Elevated Plus Maze task, this represents the percentage of the total test duration that the animal spends in the user-defined 'Center' zone of the maze. Unit: %" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 
 [Term]
 id: EMPTY:0000048
 name: elevated plus maze: center - latency to first entry
-def: "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Center' zone. If the animal starts in the center, this value may be zero or not applicable. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Center' zone. If the animal starts in the center, this value may be zero or not applicable. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000091 ! timepoint
 
 [Term]
 id: EMPTY:0000049
 name: elevated plus maze: center - time moving towards
-def: "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Center' zone of the maze (e.g., from an arm). Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Center' zone of the maze (e.g., from an arm). Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000050
 name: elevated plus maze: center - time freezing
-def: "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined 'Center' zone of the maze. Freezing in this relatively exposed area can indicate high anxiety. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined 'Center' zone of the maze. Freezing in this relatively exposed area can indicate high anxiety. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
@@ -9174,7 +9277,7 @@ is_a: EMPTY:0000084 ! categorical identifier
 [Term]
 id: EMPTY:0000053
 name: fear-potentiated startle: baseline acoustic startle response amplitude
-def: "In the Fear-potentiated startle paradigm, this is the amplitude of the acoustic startle response (ASR) measured in response to a startle-eliciting stimulus (e.g., 95-dB white noise burst) prior to any fear conditioning procedures, typically assessed during habituation or pre-conditioning phase. This measurement serves as a reference point for later comparisons with post-conditioning startle responses. Unit of measure: arbitrary units or standardized score." []
+def: "In the Fear-potentiated startle paradigm, this is the amplitude of the acoustic startle response (ASR) measured in response to a startle-eliciting stimulus (e.g., 95-dB white noise burst) prior to any fear conditioning procedures, typically assessed during habituation or pre-conditioning phase. This measurement serves as a reference point for later comparisons with post-conditioning startle responses. Unit: arbitrary units or standardized score." []
 is_a: EMPTY:0000004 ! acoustic startle response measurement
 is_a: EMPTY:0000162 ! amplitude
 
@@ -9206,7 +9309,7 @@ is_a: EMPTY:0000093 ! fear-potentiated startle parameter
 [Term]
 id: EMPTY:0000058
 name: fear-potentiated startle: apparatus chamber identifier
-def: "Identifier for the specific Plexiglas enclosure or sound-attenuating chamber within the Fear-Potentiated Startle (FPS) apparatus (e.g., San Diego Instruments SR-Lab) in which a subject was tested for a given trial. Unit of measure: count or identifier string" []
+def: "Identifier for the specific Plexiglas enclosure or sound-attenuating chamber within the Fear-Potentiated Startle (FPS) apparatus (e.g., San Diego Instruments SR-Lab) in which a subject was tested for a given trial. Unit: count or identifier string" []
 is_a: EMPTY:0000093 ! fear-potentiated startle parameter
 
 [Term]
@@ -9218,40 +9321,40 @@ is_a: EMPTY:0000084 ! categorical identifier
 [Term]
 id: EMPTY:0000060
 name: acoustic startle response: number of samples
-def: "The total number of data points (samples) recorded and analyzed for a single acoustic startle response, typically within a defined time window following stimulus onset (e.g., a 200-ms window as mentioned in the manuscript). Unit of measure: count" []
+def: "The total number of data points (samples) recorded and analyzed for a single acoustic startle response, typically within a defined time window following stimulus onset (e.g., a 200-ms window as mentioned in the manuscript). Unit: count" []
 is_a: EMPTY:0000093 ! fear-potentiated startle parameter
 
 [Term]
 id: EMPTY:0000061
 name: acoustic startle response: sampling rate
-def: "The rate at which the analog startle response signal was digitized during data acquisition. Unit of measure: Hertz (Hz)" []
+def: "The rate at which the analog startle response signal was digitized during data acquisition. Unit: Hertz (Hz)" []
 is_a: EMPTY:0000093 ! fear-potentiated startle parameter
 
 [Term]
 id: EMPTY:0000062
 name: acoustic startle response: startle window onset amplitude
-def: "The amplitude of the digitized acoustic startle response signal at the very beginning (onset) of the defined analysis window (e.g., a 200-ms window) used to quantify the reflex. Unit of measure: millivolts (mV) or arbitrary units based on transducer calibration." []
+def: "The amplitude of the digitized acoustic startle response signal at the very beginning (onset) of the defined analysis window (e.g., a 200-ms window) used to quantify the reflex. Unit: millivolts (mV) or arbitrary units based on transducer calibration." []
 is_a: EMPTY:0000004 ! acoustic startle response measurement
 is_a: EMPTY:0000162 ! amplitude
 
 [Term]
 id: EMPTY:0000063
 name: acoustic startle response: maximum amplitude
-def: "The peak amplitude of the acoustic startle response (e.g., 'jump amplitude') detected within the defined analysis window (e.g., 200-ms window) for a given trial. Unit of measure: millivolts (mV) or arbitrary units." []
+def: "The peak amplitude of the acoustic startle response (e.g., 'jump amplitude') detected within the defined analysis window (e.g., 200-ms window) for a given trial. Unit: millivolts (mV) or arbitrary units." []
 is_a: EMPTY:0000004 ! acoustic startle response measurement
 is_a: EMPTY:0000162 ! amplitude
 
 [Term]
 id: EMPTY:0000064
 name: acoustic startle response: time to maximum amplitude
-def: "The latency from the onset of the startle-eliciting stimulus (or the beginning of the analysis window) to the occurrence of the maximum (peak) amplitude of the acoustic startle response. Unit of measure: milliseconds (ms)" []
+def: "The latency from the onset of the startle-eliciting stimulus (or the beginning of the analysis window) to the occurrence of the maximum (peak) amplitude of the acoustic startle response. Unit: milliseconds (ms)" []
 is_a: EMPTY:0000004 ! acoustic startle response measurement
 is_a: EMPTY:0000091 ! timepoint
 
 [Term]
 id: EMPTY:0000065
 name: acoustic startle response: average amplitude
-def: "The average amplitude of the digitized acoustic startle response signal calculated across the entire duration of the defined analysis window (e.g., 200-ms window). Unit of measure: millivolts (mV) or arbitrary units." []
+def: "The average amplitude of the digitized acoustic startle response signal calculated across the entire duration of the defined analysis window (e.g., 200-ms window). Unit: millivolts (mV) or arbitrary units." []
 is_a: EMPTY:0000004 ! acoustic startle response measurement
 is_a: EMPTY:0000162 ! amplitude
 
@@ -9271,7 +9374,7 @@ is_a: EMPTY:0000093 ! fear-potentiated startle parameter
 [Term]
 id: EMPTY:0000068
 name: elevated plus maze: test duration
-def: "In the Elevated Plus Maze task, this is the time of the total test duration in seconds'). Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this is the time of the total test duration in seconds'). Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 is_a: EMPTY:0000092 ! elevated plus maze parameter
@@ -9975,13 +10078,13 @@ is_a: EMPTY:0000164 ! contextual fear conditioning parameter
 [Term]
 id: EMPTY:0000175
 name: contextual fear conditioning: time freezing
-def: "The number of seconds the individual spent freezing during a given period of time. Unit of measure: seconds" []
+def: "The number of seconds the individual spent freezing during a given period of time. Unit: seconds" []
 is_a: EMPTY:0000163 ! contextual fear conditioning measurement
 
 [Term]
 id: EMPTY:0000176
 name: contextual fear conditioning: block duration
-def: "In the contextual fear conditioning paradigm, this is the time of the block duration in seconds. Unit of measure: seconds" []
+def: "In the contextual fear conditioning paradigm, this is the time of the block duration in seconds. Unit: seconds" []
 is_a: EMPTY:0000163 ! contextual fear conditioning measurement
 is_a: EMPTY:0000164 ! contextual fear conditioning parameter
 
@@ -10321,6 +10424,175 @@ name: unknown electronic file type
 def: "A digital file for which the format, encoding, or origin cannot be definitively identified by the system or investigator, necessitating further manual review or specialized software for interpretation." []
 is_a: NCIT:C172272 ! Electronic File Content Type
 
+[Term]
+id: EMPTY:0000231
+name: C. elegans chemotaxis assay parameter
+def: "A parameter that specifies the technical settings, environmental conditions, or experimental design of a chemotaxis assay involving Caenorhabditis elegans." []
+is_a: EMPTY:0000101 ! C. elegans behavioral assay parameter
+
+[Term]
+id: EMPTY:0000232
+name: C. elegans chemotaxis assay parameter: chemoattractant mixture table
+def: "A table containing the quantities and identities of all chemicals used as a chemoattractant (e.g., isoamyl alcohol, diacetyl) to elicit a directed movement response in C. elegans." []
+is_a: EMPTY:0000231 ! C. elegans chemotaxis assay parameter
+
+[Term]
+id: EMPTY:0000233
+name: C. elegans chemotaxis assay parameter: chemoattractant mixture volume
+def: "The volume of the chemoattractant mixture pipetted onto the agar plate in a chemotaxis assay. Unit: microliters (μL)." []
+is_a: EMPTY:0000231 ! C. elegans chemotaxis assay parameter
+
+[Term]
+id: EMPTY:0000234
+name: C. elegans chemotaxis assay parameter: assay duration
+def: "The total time elapsed from the point at which C. elegans are placed on the assay plate until the movement is arrested or the final positions are recorded. Unit: minutes." []
+is_a: EMPTY:0000231 ! C. elegans chemotaxis assay parameter
+
+[Term]
+id: EMPTY:0000235
+name: C. elegans chemotaxis assay measurement
+def: "A quantitative or qualitative value derived from a C. elegans chemotaxis assay, typically describing the efficiency or directionality of the animals' movement toward or away from a chemical source." []
+is_a: EMPTY:0000100 ! C. elegans behavioral assay measurement
+
+[Term]
+id: EMPTY:0000236
+name: C. elegans chemotaxis assay measurement: McCutcheon index
+def: "A behavioral measurement of chemotactic efficiency defined as the ratio of the straight-line displacement toward the attractant to the total path length traveled by the organism. Values range from -1 to 1." []
+synonym: "chemotactic ratio" EXACT []
+is_a: EMPTY:0000235 ! C. elegans chemotaxis assay measurement
+
+[Term]
+id: EMPTY:0000237
+name: C. elegans chemotaxis assay measurement: mean velocity
+def: "The average speed of a C. elegans individual or population during the duration of the chemotaxis assay. Unit: micrometers per second (µm/s)." []
+is_a: EMPTY:0000235 ! C. elegans chemotaxis assay measurement
+
+[Term]
+id: EMPTY:0000238
+name: investigator-defined strain
+def: "A specific genetic variant or line of an organism designated by the investigator, often containing unique mutations, transgenes, or genomic edits not yet categorized in a public repository." []
+is_a: EMPTY:0000076 ! descriptor
+
+[Term]
+id: EMPTY:0000239
+name: C. elegans strain
+def: "A specific strain of Caenorhabditis elegans, identified by its genotype or a standard nomenclature (e.g., N2, CB4856), used in experimental procedures." []
+is_a: EMPTY:0000238 ! investigator-defined strain
+
+[Term]
+id: EMPTY:0000240
+name: BAB9001
+def: "A C. elegans strain with the genotype daf-22 (m130). This strain was originally obtained from the Caenorhabditis Genetics Center (CGC) as strain DR476 and subsequently outcrossed three times. [Source: https://doi.org/TBD]" []
+is_a: EMPTY:0000239 ! C. elegans strain
+
+[Term]
+id: EMPTY:0000241
+name: BAB9002
+def: "A C. elegans klp-6 rescue strain with the genotype klp-6 (my8); Pklp-6::GFP::KLP-6 (array, IndEx 9002). [Source: https://doi.org/TBD]" []
+is_a: EMPTY:0000239 ! C. elegans strain
+
+[Term]
+id: EMPTY:0000242
+name: TM5848
+def: "A C. elegans strain with the genotype cil-7 (tm5848) I, exhibiting a him phenotype. This strain was obtained from the National BioResource Project (NBRP), Japan. [Source: https://doi.org/TBD]" []
+is_a: EMPTY:0000239 ! C. elegans strain
+
+[Term]
+id: EMPTY:0000243
+name: PT3602
+def: "A C. elegans strain with the genotype cil-7 (my61[cil-7::mNG])I; him-5(e1490) V. This strain was provided as a gift from the Maureen Barr lab. [Source: https://doi.org/TBD]" []
+is_a: EMPTY:0000239 ! C. elegans strain
+
+[Term]
+id: EMPTY:0000244
+name: BAB9003
+def: "A C. elegans strain with the genotype PT3602; Pnlp-43_hCaspase nZ (array IndEx 9003). [Source: https://doi.org/TBD]" []
+is_a: EMPTY:0000239 ! C. elegans strain
+
+[Term]
+id: EMPTY:0000245
+name: BAB9004
+def: "A C. elegans strain with the genotype PT3602; Pklp-6_hCaspase Cz (array IndEx 9004). [Source: https://doi.org/TBD]" []
+is_a: EMPTY:0000239 ! C. elegans strain
+
+[Term]
+id: EMPTY:0000246
+name: BAB9005
+def: "A C. elegans strain with the genotype PT3602; Pnlp-43_hCaspase nZ (array IndEx 9003) and Pklp-6_hCaspase Cz (array IndEx 9004). [Source: https://doi.org/TBD]" []
+is_a: EMPTY:0000239 ! C. elegans strain
+
+[Term]
+id: EMPTY:0000247
+name: fluorescence imaging measurement
+def: "fluorescence imaging measurement" []
+is_a: EMPTY:0000001 ! measurement
+
+[Term]
+id: EMPTY:0000248
+name: mean fluorescence intensity
+def: "Mean fluorescence intensity. Unit: arbitrary units (AU)" []
+is_a: EMPTY:0000247 ! fluorescence imaging measurement
+
+[Term]
+id: EMPTY:0000249
+name: fluorescent punctal count
+def: "A quantitative measurement of the number of distinct fluorescent spots or puncta detected within a defined region of interest in a fluorescence image. Unit: count" []
+is_a: EMPTY:0000247 ! fluorescence imaging measurement
+
+[Term]
+id: EMPTY:0000250
+name: fluorescence imaging parameter
+def: "A specific parameter related to fluorescence imaging acquisition or assay." []
+is_a: EMPTY:0000080 ! parameter
+
+[Term]
+id: EMPTY:0000251
+name: fluorescence target ontology identifier
+def: "fluorescence target ontology identifier" []
+is_a: EMPTY:0000250 ! fluorescence imaging parameter
+
+[Term]
+id: EMPTY:0000252
+name: fluorescence target name
+def: "fluorescence target name" []
+is_a: EMPTY:0000250 ! fluorescence imaging parameter
+
+[Term]
+id: EMPTY:0000253
+name: SnapGene file format
+def: "A .dna file format designed for storing annotated DNA sequences, including linear/circular topology, features, primers, and enzyme sites." []
+is_a: format:1929
+
+[Term]
+id: EMPTY:0000254
+name: Escherichia coli OP50: heat-killed
+def: "A preparation of Escherichia coli strain OP50 that has been rendered non-viable through the application of heat, typically used as a non-proliferating food source in C. elegans assays." []
+is_a: NCBITaxon:637912 ! Escherichia coli OP50
+
+[Term]
+id: EMPTY:0000255
+name: C. elegans transfer method: M9 buffer wash
+def: "Method used to transfer C. elegans whereby an M9 buffer is used to wash C. elegans off of an agar plate. Animals can then be transferred using a piper." []
+is_a: EMPTY:0000189 ! treatment
+
+[Term]
+id: EMPTY:0000256
+name: C. elegans transfer method: titanium pick
+def: "Method used to transfer C. elegans whereby a titanium pick is used to scoop animals off of an agar plate." []
+is_a: EMPTY:0000189 ! treatment
+
+[Term]
+id: EMPTY:0000257
+name: C. elegans chemotaxis assay: video recording
+def: "A video recording capturing the behavior of C. elegans during a chemotaxis assay." []
+is_a: EMPTY:0000129 ! C. elegans behavioral assay: video recording
+
+[Term]
+id: EMPTY:0000258
+name: fluorescence imaging data
+def: "An image or video acquired using fluorescence microscopy." []
+is_a: NCIT:C16856 ! Fluorescence Microscopy
+
 [Term]
 id: GO:0000011
 name: vacuole inheritance
@@ -16125,6 +16397,7 @@ name: biological_process
 synonym: "biological process" EXACT []
 synonym: "physiological process" EXACT []
 is_a: BFO:0000015 ! process
+relationship: BFO:0000051 GO:0003674 ! has part molecular_function
 
 [Term]
 id: GO:0008152
@@ -17085,6 +17358,14 @@ intersection_of: GO:0008356 ! asymmetric cell division
 intersection_of: RO:0004009 CL:0000365 ! has primary input animal zygote
 relationship: RO:0004009 CL:0000365 ! has primary input animal zygote
 
+[Term]
+id: GO:0010155
+name: regulation of proton transport
+is_a: GO:1904062 ! regulation of monoatomic cation transmembrane transport
+intersection_of: GO:0065007 ! biological regulation
+intersection_of: RO:0002211 GO:1902600 ! regulates (processual) proton transmembrane transport
+relationship: RO:0002211 GO:1902600 ! regulates (processual) proton transmembrane transport
+
 [Term]
 id: GO:0010160
 name: formation of animal organ boundary
@@ -18776,22 +19057,6 @@ intersection_of: GO:0050896 ! response to stimulus
 intersection_of: BFO:0000050 GO:0043502 ! part of regulation of muscle adaptation
 relationship: BFO:0000050 GO:0043502 ! part of regulation of muscle adaptation
 
-[Term]
-id: GO:0014878
-name: response to electrical stimulus involved in regulation of muscle adaptation
-is_a: GO:0014874 ! response to stimulus involved in regulation of muscle adaptation
-is_a: GO:0051602 ! response to electrical stimulus
-intersection_of: GO:0051602 ! response to electrical stimulus
-intersection_of: BFO:0000050 GO:0043502 ! part of regulation of muscle adaptation
-
-[Term]
-id: GO:0014879
-name: detection of electrical stimulus involved in regulation of muscle adaptation
-is_a: GO:0014878 ! response to electrical stimulus involved in regulation of muscle adaptation
-is_a: GO:0050981 ! detection of electrical stimulus
-intersection_of: GO:0050981 ! detection of electrical stimulus
-intersection_of: BFO:0000050 GO:0043502 ! part of regulation of muscle adaptation
-
 [Term]
 id: GO:0014887
 name: cardiac muscle adaptation
@@ -18899,6 +19164,18 @@ intersection_of: RO:0004009 CHEBI:24867 ! has primary input monoatomic ion
 relationship: BFO:0000050 GO:0034220 ! part of monoatomic ion transmembrane transport
 relationship: RO:0004009 CHEBI:24867 ! has primary input monoatomic ion
 
+[Term]
+id: GO:0015078
+name: proton transmembrane transporter activity
+synonym: "hydrogen ion transmembrane transporter activity" EXACT []
+synonym: "proton transporter activity" EXACT []
+is_a: GO:0008324 ! monoatomic cation transmembrane transporter activity
+intersection_of: GO:0005215 ! transporter activity
+intersection_of: RO:0002342 GO:0016020 ! results in transport across membrane
+intersection_of: RO:0004009 CHEBI:15378 ! has primary input hydron
+relationship: BFO:0000050 GO:1902600 ! part of proton transmembrane transport
+relationship: RO:0004009 CHEBI:15378 ! has primary input hydron
+
 [Term]
 id: GO:0015081
 name: sodium ion transmembrane transporter activity
@@ -19836,7 +20113,7 @@ intersection_of: GO:0042592 ! homeostatic process
 intersection_of: BFO:0000066 CL:0000000 ! occurs in cell
 disjoint_from: GO:0048872 ! homeostasis of number of cells
 relationship: BFO:0000066 CL:0000000 ! occurs in cell
-relationship: RO:0002162 NCBITaxon:131567 ! in taxon cellular organisms
+relationship: RO:0002162 NCBITaxon:131567 ! in taxon cellular organism
 
 [Term]
 id: GO:0019748
@@ -22229,6 +22506,7 @@ synonym: "proteinaceous extracellular matrix" EXACT []
 is_a: GO:0030312 ! external encapsulating structure
 disjoint_from: GO:0032991 ! protein-containing complex
 disjoint_from: GO:0043226 ! organelle
+disjoint_from: GO:0044423 ! virion component
 
 [Term]
 id: GO:0031016
@@ -23425,7 +23703,7 @@ is_a: GO:0045185 ! maintenance of protein location
 is_a: GO:0051651 ! maintenance of location in cell
 intersection_of: GO:0045185 ! maintenance of protein location
 intersection_of: BFO:0000066 CL:0000000 ! occurs in cell
-relationship: RO:0002162 NCBITaxon:131567 ! in taxon cellular organisms
+relationship: RO:0002162 NCBITaxon:131567 ! in taxon cellular organism
 
 [Term]
 id: GO:0032528
@@ -23858,6 +24136,7 @@ synonym: "macromolecule complex" EXACT []
 synonym: "protein containing complex" EXACT []
 is_a: COB:0000080 ! complex of molecules
 is_a: GO:0005575 ! cellular_component
+disjoint_from: GO:0044423 ! virion component
 disjoint_from: GO:0110165 ! cellular anatomical entity
 relationship: BFO:0000051 PR:000000001 ! has part protein
 property_value: IAO:0000118 "protein complex" xsd:string
@@ -25365,7 +25644,7 @@ relationship: RO:0012008 GO:0000139 ! results in fusion of Golgi membrane
 id: GO:0040007
 name: growth
 is_a: GO:0008150 ! biological_process
-relationship: RO:0002162 NCBITaxon:131567 ! in taxon cellular organisms
+relationship: RO:0002162 NCBITaxon:131567 ! in taxon cellular organism
 
 [Term]
 id: GO:0040008
@@ -26540,6 +26819,7 @@ relationship: BFO:0000050 CL:0000125 ! part of glial cell
 id: GO:0043226
 name: organelle
 is_a: GO:0110165 ! cellular anatomical entity
+disjoint_from: GO:0044423 ! virion component
 
 [Term]
 id: GO:0043227
@@ -26814,7 +27094,7 @@ relationship: RO:0002211 GO:0016052 ! regulates (processual) carbohydrate catabo
 id: GO:0043473
 name: pigmentation
 is_a: GO:0008150 ! biological_process
-relationship: RO:0002162 NCBITaxon:131567 ! in taxon cellular organisms
+relationship: RO:0002162 NCBITaxon:131567 ! in taxon cellular organism
 
 [Term]
 id: GO:0043500
@@ -27310,7 +27590,9 @@ is_a: GO:0008150 ! biological_process
 id: GO:0044423
 name: virion component
 def: "Any constituent part of a virion, a complete fully infectious extracellular virus particle." []
+synonym: "virion part" EXACT []
 is_a: GO:0005575 ! cellular_component
+disjoint_from: GO:0110165 ! cellular anatomical entity
 
 [Term]
 id: GO:0044458
@@ -32065,11 +32347,6 @@ intersection_of: GO:0065007 ! biological regulation
 intersection_of: RO:0002213 GO:0050931 ! positively regulates pigment cell differentiation
 relationship: RO:0002213 GO:0050931 ! positively regulates pigment cell differentiation
 
-[Term]
-id: GO:0050952
-name: sensory perception of electrical stimulus
-is_a: GO:0007600 ! sensory perception
-
 [Term]
 id: GO:0050953
 name: sensory perception of light stimulus
@@ -32082,13 +32359,6 @@ synonym: "mechanosensory perception" EXACT []
 synonym: "perception of mechanical stimulus" EXACT []
 is_a: GO:0007600 ! sensory perception
 
-[Term]
-id: GO:0050956
-name: electroception
-synonym: "electroception sense" EXACT []
-synonym: "electroceptive sense" EXACT []
-is_a: GO:0050952 ! sensory perception of electrical stimulus
-
 [Term]
 id: GO:0050962
 name: detection of light stimulus involved in sensory perception
@@ -32104,44 +32374,6 @@ intersection_of: GO:0009583 ! detection of light stimulus
 intersection_of: BFO:0000050 GO:0007600 ! part of sensory perception
 relationship: BFO:0000050 GO:0050953 ! part of sensory perception of light stimulus
 
-[Term]
-id: GO:0050963
-name: detection of electrical stimulus involved in sensory perception
-synonym: "sensory detection of electrical stimulus" EXACT []
-synonym: "sensory detection of electrical stimulus during sensory perception" EXACT []
-synonym: "sensory perception, sensory detection of electrical stimulus" EXACT []
-synonym: "sensory perception, sensory transduction of electrical stimulus" EXACT []
-synonym: "sensory transduction of electrical stimulus" EXACT []
-synonym: "sensory transduction of electrical stimulus during sensory perception" EXACT []
-is_a: GO:0050906 ! detection of stimulus involved in sensory perception
-is_a: GO:0050981 ! detection of electrical stimulus
-intersection_of: GO:0050981 ! detection of electrical stimulus
-intersection_of: BFO:0000050 GO:0007600 ! part of sensory perception
-relationship: BFO:0000050 GO:0050952 ! part of sensory perception of electrical stimulus
-
-[Term]
-id: GO:0050964
-name: detection of electrical stimulus involved in electroception
-synonym: "electroception, detection of electrical stimulus" EXACT []
-synonym: "electroception, sensory detection of electrical stimulus" EXACT []
-synonym: "electroception, sensory transduction" EXACT []
-synonym: "electroception, sensory transduction of electrical stimulus" EXACT []
-is_a: GO:0050963 ! detection of electrical stimulus involved in sensory perception
-intersection_of: GO:0050981 ! detection of electrical stimulus
-intersection_of: BFO:0000050 GO:0050956 ! part of electroception
-relationship: BFO:0000050 GO:0050956 ! part of electroception
-
-[Term]
-id: GO:0050967
-name: detection of electrical stimulus involved in sensory perception of pain
-synonym: "perception of pain, detection of electrical stimulus" EXACT []
-synonym: "perception of pain, sensory detection of electrical stimulus" EXACT []
-synonym: "perception of pain, sensory transduction of electrical stimulus" EXACT []
-is_a: GO:0050963 ! detection of electrical stimulus involved in sensory perception
-is_a: GO:0062149 ! detection of stimulus involved in sensory perception of pain
-intersection_of: GO:0050981 ! detection of electrical stimulus
-intersection_of: BFO:0000050 GO:0019233 ! part of sensory perception of pain
-
 [Term]
 id: GO:0050968
 name: detection of chemical stimulus involved in sensory perception of pain
@@ -32164,12 +32396,6 @@ synonym: "taction" EXACT []
 synonym: "tactition" EXACT []
 is_a: GO:0050954 ! sensory perception of mechanical stimulus
 
-[Term]
-id: GO:0050981
-name: detection of electrical stimulus
-is_a: GO:0009582 ! detection of abiotic stimulus
-is_a: GO:0051602 ! response to electrical stimulus
-
 [Term]
 id: GO:0050994
 name: regulation of lipid catabolic process
@@ -33069,11 +33295,6 @@ intersection_of: GO:0065007 ! biological regulation
 intersection_of: RO:0002213 GO:0006836 ! positively regulates neurotransmitter transport
 relationship: RO:0002213 GO:0006836 ! positively regulates neurotransmitter transport
 
-[Term]
-id: GO:0051602
-name: response to electrical stimulus
-is_a: GO:0009628 ! response to abiotic stimulus
-
 [Term]
 id: GO:0051606
 name: detection of stimulus
@@ -33234,7 +33455,7 @@ intersection_of: GO:0051234 ! establishment of localization
 intersection_of: BFO:0000066 CL:0000000 ! occurs in cell
 relationship: BFO:0000050 GO:0051641 ! part of cellular localization
 relationship: BFO:0000066 CL:0000000 ! occurs in cell
-relationship: RO:0002162 NCBITaxon:131567 ! in taxon cellular organisms
+relationship: RO:0002162 NCBITaxon:131567 ! in taxon cellular organism
 
 [Term]
 id: GO:0051650
@@ -40754,6 +40975,7 @@ synonym: "cellular anatomical entity" EXACT []
 is_a: CARO:0000000 ! anatomical entity
 is_a: GO:0005575 ! cellular_component
 is_a: UBERON:0000061 ! anatomical structure
+disjoint_from: UBERON:0000001 ! gross anatomical part
 relationship: BFO:0000051 COB:0000013 ! has part molecule
 
 [Term]
@@ -40790,6 +41012,18 @@ intersection_of: GO:0042995 ! cell projection
 intersection_of: BFO:0000051 GO:0098590 ! has part plasma membrane region
 relationship: BFO:0000051 GO:0098590 ! has part plasma membrane region
 
+[Term]
+id: GO:0120029
+name: proton export across plasma membrane
+synonym: "hydrogen ion export across plasma membrane" EXACT []
+is_a: GO:0140115 ! export across plasma membrane
+is_a: GO:1902600 ! proton transmembrane transport
+intersection_of: GO:0006810 ! transport
+intersection_of: RO:0002338 GO:0005829 ! has target start location cytosol
+intersection_of: RO:0002339 GO:0005576 ! has target end location extracellular region
+intersection_of: RO:0002342 GO:0005886 ! results in transport across plasma membrane
+intersection_of: RO:0004009 CHEBI:15378 ! has primary input hydron
+
 [Term]
 id: GO:0120031
 name: plasma membrane bounded cell projection assembly
@@ -43532,6 +43766,17 @@ intersection_of: GO:0008104 ! intracellular protein localization
 intersection_of: RO:0002339 GO:0005730 ! has target end location nucleolus
 relationship: RO:0002339 GO:0005730 ! has target end location nucleolus
 
+[Term]
+id: GO:1902600
+name: proton transmembrane transport
+synonym: "hydrogen ion transmembrane transport" EXACT []
+synonym: "hydrogen transmembrane transport" EXACT []
+is_a: GO:0098655 ! monoatomic cation transmembrane transport
+is_a: GO:0098662 ! inorganic cation transmembrane transport
+intersection_of: GO:0055085 ! transmembrane transport
+intersection_of: RO:0004009 CHEBI:15378 ! has primary input hydron
+relationship: RO:0004009 CHEBI:15378 ! has primary input hydron
+
 [Term]
 id: GO:1902679
 name: negative regulation of RNA biosynthetic process
@@ -49094,7 +49339,7 @@ is_a: IAO:0000104 ! plan specification
 
 [Term]
 id: IAO:0000027
-name: data item
+name: data entity
 def: "An information content entity that is intended to be a truthful statement about something (modulo, e.g., measurement precision or other systematic errors) and is constructed/acquired by a method which reliably tends to produce (approximately) truthful statements." []
 is_a: IAO:0000030 ! information content entity
 
@@ -49143,7 +49388,7 @@ is_a: IAO:0000033 ! directive information entity
 id: IAO:0000100
 name: data set
 def: "A data item that is an aggregate of other data items of the same type that have something in common. Averages and distributions can be determined for data sets." []
-is_a: IAO:0000027 ! data item
+is_a: IAO:0000027 ! data entity
 
 [Term]
 id: IAO:0000101
@@ -49155,7 +49400,7 @@ is_a: IAO:0000308 ! figure
 id: IAO:0000102
 name: data about an ontology part
 def: "Data about an ontology part is a data item about a part of an ontology, for example a term" []
-is_a: IAO:0000027 ! data item
+is_a: IAO:0000027 ! data entity
 
 [Term]
 id: IAO:0000104
@@ -49386,6 +49631,16 @@ id: NCBITaxon:1206795
 name: Lophotrochozoa
 is_a: NCBITaxon:2697495 ! Spiralia
 
+[Term]
+id: NCBITaxon:1224
+name: Pseudomonadota
+is_a: NCBITaxon:3379134 ! Pseudomonadati
+
+[Term]
+id: NCBITaxon:1236
+name: Gammaproteobacteria
+is_a: NCBITaxon:1224 ! Pseudomonadota
+
 [Term]
 id: NCBITaxon:124129
 name: Acipenserinae
@@ -49415,7 +49670,8 @@ disjoint_from: NCBITaxon:33511 ! Deuterostomia
 
 [Term]
 id: NCBITaxon:131567
-name: cellular organisms
+name: cellular organism
+is_a: COB:0000022 ! organism
 is_a: NCBITaxon:1 ! root
 
 [Term]
@@ -49528,7 +49784,7 @@ is_a: NCBITaxon:6656 ! Arthropoda
 [Term]
 id: NCBITaxon:2
 name: Bacteria
-is_a: NCBITaxon:131567 ! cellular organisms
+is_a: NCBITaxon:131567 ! cellular organism
 
 [Term]
 id: NCBITaxon:2058185
@@ -49548,7 +49804,7 @@ is_a: NCBITaxon:9604 ! Hominidae
 [Term]
 id: NCBITaxon:2157
 name: Archaea
-is_a: NCBITaxon:131567 ! cellular organisms
+is_a: NCBITaxon:131567 ! cellular organism
 
 [Term]
 id: NCBITaxon:2301116
@@ -49603,9 +49859,7 @@ is_a: NCBITaxon:2743709 ! Danionidae
 [Term]
 id: NCBITaxon:2759
 name: Eukaryota
-is_a: COB:0000022 ! organism
-is_a: NCBITaxon:131567 ! cellular organisms
-property_value: IAO:0000118 "eucaryotes" xsd:string
+is_a: NCBITaxon:131567 ! cellular organism
 property_value: IAO:0000118 "eukaryotes" xsd:string
 
 [Term]
@@ -49736,6 +49990,7 @@ id: NCBITaxon:33208
 name: Metazoa
 is_a: NCBITaxon:33154 ! Opisthokonta
 disjoint_from: NCBITaxon:4751 ! Fungi
+property_value: IAO:0000118 "animals" xsd:string
 property_value: IAO:0000118 "metazoans" xsd:string
 property_value: IAO:0000118 "multicellular animals" xsd:string
 
@@ -49791,6 +50046,11 @@ id: NCBITaxon:3378
 name: Gnetales
 is_a: NCBITaxon:1445966 ! Gnetidae
 
+[Term]
+id: NCBITaxon:3379134
+name: Pseudomonadati
+is_a: NCBITaxon:2 ! Bacteria
+
 [Term]
 id: NCBITaxon:3398
 name: Magnoliopsida
@@ -49968,6 +50228,11 @@ id: NCBITaxon:50557
 name: Insecta
 is_a: NCBITaxon:6960 ! Hexapoda
 
+[Term]
+id: NCBITaxon:543
+name: Enterobacteriaceae
+is_a: NCBITaxon:91347 ! Enterobacterales
+
 [Term]
 id: NCBITaxon:554915
 name: Amoebozoa
@@ -49983,6 +50248,16 @@ id: NCBITaxon:55885
 name: Peloderinae
 is_a: NCBITaxon:6243 ! Rhabditidae
 
+[Term]
+id: NCBITaxon:561
+name: Escherichia
+is_a: NCBITaxon:543 ! Enterobacteriaceae
+
+[Term]
+id: NCBITaxon:562
+name: Escherichia coli
+is_a: NCBITaxon:561 ! Escherichia
+
 [Term]
 id: NCBITaxon:5782
 name: Dictyostelium
@@ -50061,6 +50336,11 @@ id: NCBITaxon:6362
 name: Sabellida
 is_a: NCBITaxon:105391 ! Canalipalpata
 
+[Term]
+id: NCBITaxon:637912
+name: Escherichia coli OP50
+is_a: NCBITaxon:562 ! Escherichia coli
+
 [Term]
 id: NCBITaxon:6656
 name: Arthropoda
@@ -50331,6 +50611,11 @@ id: NCBITaxon:89593
 name: Craniata <chordates>
 is_a: NCBITaxon:7711 ! Chordata
 
+[Term]
+id: NCBITaxon:91347
+name: Enterobacterales
+is_a: NCBITaxon:1236 ! Gammaproteobacteria
+
 [Term]
 id: NCBITaxon:9254
 name: Prototheria
@@ -50429,11 +50714,27 @@ id: NCIT:C14376
 name: Other Organism Groupings
 is_a: NCIT:C14250 ! Organism
 
+[Term]
+id: NCIT:C16203
+name: Clinical or Research Activity
+is_a: NCIT:C43431 ! Activity
+
 [Term]
 id: NCIT:C16847
 name: Technique
 is_a: NCIT:C43431 ! Activity
 
+[Term]
+id: NCIT:C16853
+name: Microscopy
+is_a: NCIT:C17369 ! Imaging Procedure
+is_a: NCIT:C74957 ! Mixed Category Laboratory Procedure
+
+[Term]
+id: NCIT:C16856
+name: Fluorescence Microscopy
+is_a: NCIT:C17995 ! Light Microscopy
+
 [Term]
 id: NCIT:C17187
 name: Technology
@@ -50444,12 +50745,22 @@ id: NCIT:C172272
 name: Electronic File Content Type
 is_a: NCIT:C25284 ! Type
 
+[Term]
+id: NCIT:C17369
+name: Imaging Procedure
+is_a: NCIT:C25218 ! Clinical Intervention or Procedure
+
 [Term]
 id: NCIT:C179817
 name: Velocity
 is_a: NCIT:C25447 ! Characteristic
 is_a: NCIT:C70766 ! Quantitative Concept
 
+[Term]
+id: NCIT:C17995
+name: Light Microscopy
+is_a: NCIT:C16853 ! Microscopy
+
 [Term]
 id: NCIT:C18141
 name: Computer Sciences
@@ -50522,6 +50833,11 @@ id: NCIT:C25206
 name: Temperature
 is_a: NCIT:C25447 ! Characteristic
 
+[Term]
+id: NCIT:C25218
+name: Clinical Intervention or Procedure
+is_a: NCIT:C16203 ! Clinical or Research Activity
+
 [Term]
 id: NCIT:C25284
 name: Type
@@ -50532,6 +50848,11 @@ id: NCIT:C25285
 name: Diameter
 is_a: NCIT:C70766 ! Quantitative Concept
 
+[Term]
+id: NCIT:C25294
+name: Laboratory Procedure
+is_a: NCIT:C25218 ! Clinical Intervention or Procedure
+
 [Term]
 id: NCIT:C25335
 name: Volume
@@ -50647,6 +50968,11 @@ id: NCIT:C73706
 name: Spatial Qualifier
 is_a: NCIT:C41009 ! Qualifier
 
+[Term]
+id: NCIT:C74957
+name: Mixed Category Laboratory Procedure
+is_a: NCIT:C25294 ! Laboratory Procedure
+
 [Term]
 id: NCIT:C85776
 name: Optical Density Measurement
@@ -51087,9 +51413,9 @@ id: OBI:0200000
 name: data transformation
 def: "A completely executed planned process that produces output data from input data." []
 is_a: COB:0000035 ! completely executed planned process
-relationship: OBI:0000293 IAO:0000027 {all_only="true"} ! has specified input data item
-relationship: OBI:0000293 IAO:0000027 ! has specified input data item
-relationship: OBI:0000299 IAO:0000027 ! has specified output data item
+relationship: OBI:0000293 IAO:0000027 {all_only="true"} ! has specified input data entity
+relationship: OBI:0000293 IAO:0000027 ! has specified input data entity
+relationship: OBI:0000299 IAO:0000027 ! has specified output data entity
 relationship: OBI:0000417 OBI:0200166 ! achieves_planned_objective data transformation objective
 property_value: IAO:0000118 "data analysis" xsd:string
 property_value: IAO:0000118 "data processing" xsd:string
@@ -51138,8 +51464,8 @@ id: OBI:0200111
 name: data visualization
 def: "A planned process with the objective to graphically represent some data by inputing the data and outputting images, diagrams or animations." []
 is_a: COB:0000035 ! completely executed planned process
-relationship: OBI:0000293 IAO:0000027 {all_only="true"} ! has specified input data item
-relationship: OBI:0000293 IAO:0000027 ! has specified input data item
+relationship: OBI:0000293 IAO:0000027 {all_only="true"} ! has specified input data entity
+relationship: OBI:0000293 IAO:0000027 ! has specified input data entity
 property_value: IAO:0000118 "data encoding as image" xsd:string
 property_value: IAO:0000118 "visualization" xsd:string
 
@@ -53061,9 +53387,14 @@ is_a: BFO:0000040 ! material entity
 [Term]
 id: UBERON:0000000
 name: processual entity
-is_a: BFO:0000003 ! occurrent
 disjoint_from: UBERON:0001062 ! anatomical entity
 
+[Term]
+id: UBERON:0000001
+name: gross anatomical part
+is_a: UBERON:0000465 ! material anatomical entity
+disjoint_from: UBERON:0000468 ! multicellular organism
+
 [Term]
 id: UBERON:0000005
 name: chemosensory organ
@@ -53320,6 +53651,7 @@ relationship: RO:0002220 UBERON:0002553 ! adjacent to anatomical cavity
 [Term]
 id: UBERON:0000061
 name: anatomical structure
+def: "Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome." []
 synonym: "biological structure" EXACT []
 is_a: UBERON:0000465 ! material anatomical entity
 relationship: RO:0002496 UBERON:0000106 {gci_filler="NCBITaxon:33208", gci_relation="RO:0002162"} ! existence starts during or after zygote stage
@@ -53533,6 +53865,7 @@ synonym: "entire life cycle" EXACT []
 synonym: "entire lifespan" EXACT []
 synonym: "life" EXACT []
 synonym: "lifespan" EXACT []
+is_a: BFO:0000015 ! process
 is_a: UBERON:0000000 ! processual entity
 relationship: RO:0002224 UBERON:0000106 {gci_filler="NCBITaxon:33208", gci_relation="RO:0002162"} ! starts with zygote stage
 relationship: RO:0002230 UBERON:0000071 ! ends with death stage
@@ -53540,6 +53873,7 @@ relationship: RO:0002230 UBERON:0000071 ! ends with death stage
 [Term]
 id: UBERON:0000105
 name: life cycle stage
+is_a: BFO:0000015 ! process
 is_a: UBERON:0000000 ! processual entity
 relationship: BFO:0000050 UBERON:0000104 ! part of life cycle
 
@@ -53757,7 +54091,6 @@ name: proximal-distal subdivision of colon
 is_a: UBERON:0004921 ! subdivision of digestive tract
 intersection_of: UBERON:0013522 ! subdivision of tube
 intersection_of: subdivision_of UBERON:0001155 ! colon
-relationship: BFO:0000050 UBERON:0001155 ! part of colon
 relationship: subdivision_of UBERON:0001155 ! colon
 
 [Term]
@@ -54155,7 +54488,8 @@ relationship: RO:0020101 UBERON:0001675 ! vessel supplies blood to trigeminal ga
 [Term]
 id: UBERON:0000463
 name: organism substance
-is_a: UBERON:0000465 ! material anatomical entity
+is_a: UBERON:0000001 ! gross anatomical part
+disjoint_from: UBERON:0000468 ! multicellular organism
 relationship: BFO:0000050 UBERON:0000468 ! part of multicellular organism
 relationship: RO:0000086 PATO:0002198 ! has quality quality of a substance
 
@@ -54229,6 +54563,7 @@ relationship: RO:0002131 UBERON:0002416 {gci_filler="NCBITaxon:6072", gci_relati
 [Term]
 id: UBERON:0000476
 name: acellular anatomical structure
+is_a: UBERON:0000001 ! gross anatomical part
 is_a: UBERON:0000061 ! anatomical structure
 
 [Term]
@@ -63602,7 +63937,6 @@ name: subdivision of digestive tract
 is_a: UBERON:0013522 ! subdivision of tube
 intersection_of: UBERON:0013522 ! subdivision of tube
 intersection_of: subdivision_of UBERON:0001555 ! digestive tract
-relationship: BFO:0000050 UBERON:0001555 ! part of digestive tract
 relationship: subdivision_of UBERON:0001555 ! digestive tract
 
 [Term]
@@ -64375,7 +64709,7 @@ relationship: RO:0002202 UBERON:0003372 ! develops from pectoral appendage bud e
 [Term]
 id: UBERON:0005423
 name: developing anatomical structure
-is_a: UBERON:0000465 ! material anatomical entity
+is_a: UBERON:0000001 ! gross anatomical part
 relationship: RO:0002215 GO:0032502 ! capable of developmental process
 
 [Term]
@@ -65187,7 +65521,6 @@ is_a: UBERON:0006077 ! subdivision of vertebral column
 intersection_of: UBERON:0006077 ! subdivision of vertebral column
 intersection_of: subdivision_of UBERON:0006071 ! caudal region
 relationship: BFO:0000050 UBERON:0002090 ! part of postcranial axial skeleton
-relationship: BFO:0000050 UBERON:0006071 ! part of caudal region
 relationship: subdivision_of UBERON:0006071 ! caudal region
 
 [Term]
@@ -65198,7 +65531,6 @@ synonym: "vertebral series" EXACT []
 is_a: UBERON:0000075 ! subdivision of skeletal system
 intersection_of: UBERON:0000075 ! subdivision of skeletal system
 intersection_of: subdivision_of UBERON:0001130 ! vertebral column
-relationship: BFO:0000050 UBERON:0001130 ! part of vertebral column
 relationship: BFO:0000050 UBERON:0001137 ! part of dorsum
 relationship: subdivision_of UBERON:0001130 ! vertebral column
 
@@ -67532,7 +67864,6 @@ is_a: UBERON:0006077 ! subdivision of vertebral column
 intersection_of: UBERON:0006077 ! subdivision of vertebral column
 intersection_of: BFO:0000050 UBERON:0002100 ! part of trunk
 intersection_of: subdivision_of UBERON:0002100 ! trunk
-relationship: BFO:0000050 UBERON:0002100 ! part of trunk
 relationship: subdivision_of UBERON:0002100 ! trunk
 
 [Term]
@@ -68862,16 +69193,6 @@ is_a: UBERON:0010498 ! pseudostratified columnar epithelium
 intersection_of: UBERON:0010498 ! pseudostratified columnar epithelium
 intersection_of: BFO:0000051 CL:0000067 ! has part ciliated epithelial cell
 
-[Term]
-id: UBERON:0010521
-name: electroreceptor organ
-synonym: "electric sense organ" EXACT []
-synonym: "electroreception organ" EXACT []
-is_a: UBERON:0000020 ! sense organ
-intersection_of: UBERON:0000062 ! organ
-intersection_of: RO:0002215 GO:0050964 ! capable of detection of electrical stimulus involved in electroception
-relationship: RO:0002215 GO:0050964 ! capable of detection of electrical stimulus involved in electroception
-
 [Term]
 id: UBERON:0010522
 name: replacement element
@@ -70299,7 +70620,6 @@ relationship: RO:0002221 UBERON:0000468 ! surrounds multicellular organism
 id: UBERON:0013522
 name: subdivision of tube
 is_a: UBERON:0000064 ! organ part
-relationship: BFO:0000050 UBERON:0000025 ! part of tube
 relationship: BFO:0000051 UBERON:0000060 ! has part anatomical wall
 relationship: BFO:0000051 UBERON:0000464 ! has part anatomical space
 relationship: subdivision_of UBERON:0000025 ! tube
@@ -72479,7 +72799,7 @@ relationship: RO:0002176 UBERON:0001159 ! connects sigmoid colon
 [Term]
 id: UBERON:0036215
 name: anatomical surface region
-is_a: UBERON:0000465 ! material anatomical entity
+is_a: UBERON:0000001 ! gross anatomical part
 relationship: RO:0002007 UBERON:0000061 ! bounding layer of anatomical structure
 
 [Term]
@@ -73293,6 +73613,14 @@ intersection_of: UBERON:0000030 ! lamina propria
 intersection_of: BFO:0000050 UBERON:0001052 ! part of rectum
 relationship: BFO:0000050 UBERON:0001052 ! part of rectum
 
+[Term]
+id: UBERON:8850001
+name: epithelium of anorectum
+is_a: UBERON:0001278 ! epithelium of large intestine
+intersection_of: UBERON:0000483 ! epithelium
+intersection_of: BFO:0000050 UBERON:8410050 ! part of anorectum
+relationship: BFO:0000050 UBERON:8410050 ! part of anorectum
+
 [Term]
 id: UO:0000001
 name: length unit
@@ -74088,7 +74416,7 @@ inverse_of: RO:0002336 ! positively regulated by
 [Typedef]
 id: RO:0002215
 name: capable of
-def: "A relation between a material entity (such as a cell) and a process, in which the material entity has the ability to carry out the process. " []
+def: "A relation between a material entity (such as a cell) and a process, in which the material entity has the ability to carry out the process." []
 property_value: IAO:0000118 "has function realized in" xsd:string
 domain: BFO:0000004 ! independent continuant
 range: BFO:0000015 ! process
@@ -75282,6 +75610,59 @@ name: device utilizes material
 def: "X device utilizes material Y means X and Y are material entities, and X is capable of some process P that has input Y." []
 holds_over_chain: RO:0002215 RO:0002233
 
+[Typedef]
+id: RO:0018030
+name: chemical relationship
+
+[Typedef]
+id: RO:0018033
+name: is deprotonated form of
+def: "A is a deprotonated form of B if and only if A is chemical entity that is a Brønsted–Lowry Base (i.e., can receive a proton) and by adding some nonzero number of protons transforms it into B.\n\nThis is a transitive relationship and follows this design pattern: https://oborel.github.io/obo-relations/direct-and-indirect-relations." []
+is_transitive: true
+is_a: RO:0018030 ! chemical relationship
+inverse_of: RO:0018034 ! is protonated form of
+
+[Typedef]
+id: RO:0018034
+name: is protonated form of
+def: "A is a protonated form of B if and only if A is chemical entity that is a Brønsted–Lowry Acid (i.e., can give up a proton) and by removing some nonzero number of protons transforms it into B.\n\nThis is a transitive relationship and follows this design pattern: https://oborel.github.io/obo-relations/direct-and-indirect-relations." []
+is_transitive: true
+is_a: RO:0018030 ! chemical relationship
+
+[Typedef]
+id: RO:0018036
+name: is tautomer of
+def: "Two chemicals are tautomers if they can be readily interconverted.\n\nThis commonly refers to prototropy in which a hydrogen's position is changed, such as between ketones and enols. This is also often observed in heterocyclic rings, e.g., ones containing nitrogens and/or have aryl functional groups containing heteroatoms." []
+synonym: "is desmotrope of" EXACT []
+is_symmetric: true
+is_a: RO:0018030 ! chemical relationship
+
+[Typedef]
+id: RO:0018037
+name: is substitutent group from
+def: "Group A is a substituent group from Chemical B if A represents the functional part of A and includes information about where it is connected. A is not itself a chemical with a fully formed chemical graph, but is rather a partial graph with one or more connection points that can be used to attach to another chemical graph, typically as a functionalization." []
+is_a: RO:0018030 ! chemical relationship
+
+[Typedef]
+id: RO:0018038
+name: has functional parent
+def: "Chemical A has functional parent Chemical B if there is chemical transformation through which chemical B can be produced from chemical A. \n\nFor example, the relationship between a salt and a freebased compound is a \"has functional parent\" relationship." []
+is_a: RO:0018030 ! chemical relationship
+
+[Typedef]
+id: RO:0018039
+name: is enantiomer of
+def: "Chemicals A and B are enantiomers if they share the same molecular graph except the change of the configuration of substituents around exactly one chiral center.\n\nA chemical with no chiral centers can not have an enantiomer. A chemical with multiple chiral centers can have multiple enantiomers, but its enantiomers are not themselves enantiomers (they are diastereomers)." []
+synonym: "is optical isomer of" EXACT []
+is_symmetric: true
+is_a: RO:0018030 ! chemical relationship
+
+[Typedef]
+id: RO:0018040
+name: has parent hydride
+def: "Chemical A has parent hydride Chemical B if there exists a molecular graphical transformation where functional groups on A are replaced with hydrogens in order to yield B." []
+is_a: RO:0018030 ! chemical relationship
+
 [Typedef]
 id: RO:0019000
 name: regulates characteristic
@@ -75420,6 +75801,7 @@ def: "c site_of p if c is the bearer of a disposition that is realized by a proc
 [Typedef]
 id: subdivision_of
 name: subdivision of
+is_a: BFO:0000050 ! part of
 
 [Typedef]
 id: transitively_anteriorly_connected_to
diff --git a/empty-full.owl b/empty-full.owl
index b96f9d0..51b7939 100644
--- a/empty-full.owl
+++ b/empty-full.owl
@@ -13,13 +13,13 @@
      xmlns:dcterms="http://purl.org/dc/terms/"
      xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#">
     <owl:Ontology rdf:about="http://purl.obolibrary.org/obo/empty/empty-full.owl">
-        <owl:versionIRI rdf:resource="http://purl.obolibrary.org/obo/empty/releases/2026-02-23/empty-full.owl"/>
+        <owl:versionIRI rdf:resource="http://purl.obolibrary.org/obo/empty/releases/2026-04-04/empty-full.owl"/>
         <dcterms:description>An ontology of experimental measurements in the sciences, the purposes for which experimental measurements were made, and experimental treatments, with a focus on life sciences.</dcterms:description>
         <dcterms:license rdf:resource="https://creativecommons.org/licenses/by/4.0/"/>
         <dcterms:title>Experimental Measurements Purposes and Treatments ontologY</dcterms:title>
         <rdfs:comment>EMPTY by NDI is licensed under CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/). You are free to share (copy and redistribute the material in any medium or format) and adapt (remix, transform, and build upon the material) for any purpose, even commercially. You must give appropriate credit (by using the original ontology IRI for the whole ontology or original term IRIs for individual terms), provide a link to the license, and indicate if any changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.</rdfs:comment>
         <owl:versionInfo>Release 2025-07-10</owl:versionInfo>
-        <owl:versionInfo>2026-02-23</owl:versionInfo>
+        <owl:versionInfo>2026-04-04</owl:versionInfo>
     </owl:Ontology>
     
 
@@ -38,8 +38,11 @@
     <!-- http://purl.obolibrary.org/obo/IAO_0000115 -->
 
     <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000115">
+        <obo:IAO_0000115>A property representing the English language definitions of what NCI means by the concept. They may also include information about the definition&apos;s source and attribution in a form that can easily be interpreted by software.</obo:IAO_0000115>
+        <obo:IAO_0000115>English language definitions of what NCI means by the concept. These are limited to 1024 characters. They may also include information about the definition&apos;s source and attribution in a form that can easily be interpreted by software.</obo:IAO_0000115>
         <obo:IAO_0000115 xml:lang="en">The official OBI definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions.</obo:IAO_0000115>
         <obo:IAO_0000115 xml:lang="en">The official definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions.</obo:IAO_0000115>
+        <obo:IAO_0000115>The official definition.</obo:IAO_0000115>
         <rdfs:label>definition</rdfs:label>
         <rdfs:label xml:lang="en">definition</rdfs:label>
         <rdfs:label>textual definition</rdfs:label>
@@ -1527,6 +1530,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.</obo:I
         <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002216"/>
         <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000004"/>
         <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
+        <obo:IAO_0000115>A relation between a material entity (such as a cell) and a process, in which the material entity has the ability to carry out the process.</obo:IAO_0000115>
         <obo:IAO_0000115>A relation between a material entity (such as a cell) and a process, in which the material entity has the ability to carry out the process. </obo:IAO_0000115>
         <obo:IAO_0000118>has function realized in</obo:IAO_0000118>
         <rdfs:label>capable of</rdfs:label>
@@ -3628,6 +3632,101 @@ For example, A and B may be gene products and binding of B by A positively regul
     
 
 
+    <!-- http://purl.obolibrary.org/obo/RO_0018030 -->
+
+    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0018030">
+        <rdfs:label>chemical relationship</rdfs:label>
+    </owl:ObjectProperty>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/RO_0018033 -->
+
+    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0018033">
+        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0018030"/>
+        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
+        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#TransitiveProperty"/>
+        <obo:IAO_0000115>A is a deprotonated form of B if and only if A is chemical entity that is a Brønsted–Lowry Base (i.e., can receive a proton) and by adding some nonzero number of protons transforms it into B.
+
+This is a transitive relationship and follows this design pattern: https://oborel.github.io/obo-relations/direct-and-indirect-relations.</obo:IAO_0000115>
+        <rdfs:label>is deprotonated form of</rdfs:label>
+    </owl:ObjectProperty>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/RO_0018034 -->
+
+    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0018034">
+        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0018030"/>
+        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#TransitiveProperty"/>
+        <obo:IAO_0000115>A is a protonated form of B if and only if A is chemical entity that is a Brønsted–Lowry Acid (i.e., can give up a proton) and by removing some nonzero number of protons transforms it into B.
+
+This is a transitive relationship and follows this design pattern: https://oborel.github.io/obo-relations/direct-and-indirect-relations.</obo:IAO_0000115>
+        <rdfs:label>is protonated form of</rdfs:label>
+    </owl:ObjectProperty>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/RO_0018036 -->
+
+    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0018036">
+        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0018030"/>
+        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#SymmetricProperty"/>
+        <obo:IAO_0000115>Two chemicals are tautomers if they can be readily interconverted.
+
+This commonly refers to prototropy in which a hydrogen&apos;s position is changed, such as between ketones and enols. This is also often observed in heterocyclic rings, e.g., ones containing nitrogens and/or have aryl functional groups containing heteroatoms.</obo:IAO_0000115>
+        <oboInOwl:hasExactSynonym>is desmotrope of</oboInOwl:hasExactSynonym>
+        <rdfs:label xml:lang="en">is tautomer of</rdfs:label>
+    </owl:ObjectProperty>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/RO_0018037 -->
+
+    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0018037">
+        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0018030"/>
+        <obo:IAO_0000115>Group A is a substituent group from Chemical B if A represents the functional part of A and includes information about where it is connected. A is not itself a chemical with a fully formed chemical graph, but is rather a partial graph with one or more connection points that can be used to attach to another chemical graph, typically as a functionalization.</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">is substitutent group from</rdfs:label>
+    </owl:ObjectProperty>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/RO_0018038 -->
+
+    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0018038">
+        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0018030"/>
+        <obo:IAO_0000115>Chemical A has functional parent Chemical B if there is chemical transformation through which chemical B can be produced from chemical A. 
+
+For example, the relationship between a salt and a freebased compound is a &quot;has functional parent&quot; relationship.</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">has functional parent</rdfs:label>
+    </owl:ObjectProperty>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/RO_0018039 -->
+
+    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0018039">
+        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0018030"/>
+        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#SymmetricProperty"/>
+        <obo:IAO_0000115>Chemicals A and B are enantiomers if they share the same molecular graph except the change of the configuration of substituents around exactly one chiral center.
+
+A chemical with no chiral centers can not have an enantiomer. A chemical with multiple chiral centers can have multiple enantiomers, but its enantiomers are not themselves enantiomers (they are diastereomers).</obo:IAO_0000115>
+        <oboInOwl:hasExactSynonym>is optical isomer of</oboInOwl:hasExactSynonym>
+        <rdfs:label xml:lang="en">is enantiomer of</rdfs:label>
+    </owl:ObjectProperty>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/RO_0018040 -->
+
+    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0018040">
+        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0018030"/>
+        <obo:IAO_0000115>Chemical A has parent hydride Chemical B if there exists a molecular graphical transformation where functional groups on A are replaced with hydrogens in order to yield B.</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">has parent hydride</rdfs:label>
+    </owl:ObjectProperty>
+    
+
+
     <!-- http://purl.obolibrary.org/obo/RO_0019000 -->
 
     <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0019000">
@@ -3760,12 +3859,6 @@ For example, A and B may be gene products and binding of B by A positively regul
     
 
 
-    <!-- http://purl.obolibrary.org/obo/chebi#is_enantiomer_of -->
-
-    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/chebi#is_enantiomer_of"/>
-    
-
-
     <!-- http://purl.obolibrary.org/obo/chebi#is_substituent_group_from -->
 
     <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/chebi#is_substituent_group_from"/>
@@ -3928,6 +4021,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <!-- http://purl.obolibrary.org/obo/uberon/core#subdivision_of -->
 
     <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/uberon/core#subdivision_of">
+        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
         <rdfs:label>subdivision of</rdfs:label>
     </owl:ObjectProperty>
     
@@ -4183,6 +4277,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_10545">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_36338"/>
         <obo:IAO_0000115>Elementary particle not affected by the strong force having a spin 1/2, a negative elementary charge and a rest mass of 0.000548579903(13) u, or 0.51099906(15) MeV.</obo:IAO_0000115>
+        <obo:IAO_0000115>Elementary particle not affected by the strong force having a spin ½, a negative elementary charge and a rest mass of 0.000548579903(13) u, or 0.51099906(15) MeV.</obo:IAO_0000115>
         <rdfs:label>electron</rdfs:label>
     </owl:Class>
     
@@ -4192,7 +4287,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_131604">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_76969"/>
-        <obo:IAO_0000115>Any bacterial metabolite produced during a metabolic reaction in Mycoplasma genitalium.</obo:IAO_0000115>
+        <obo:IAO_0000115>Any bacterial metabolite produced during a metabolic reaction in &lt;em&gt;Mycoplasma genitalium&lt;/em&gt;.</obo:IAO_0000115>
         <rdfs:label>Mycoplasma genitalium metabolite</rdfs:label>
     </owl:Class>
     
@@ -4213,6 +4308,12 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_132153">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_61469"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_63551"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_16336"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of"/>
@@ -4229,7 +4330,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_136889">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35341"/>
-        <obo:IAO_0000115>Any steroid that has beta-configuration at position 5.</obo:IAO_0000115>
+        <obo:IAO_0000115>Any steroid that has β-configuration at position 5.</obo:IAO_0000115>
         <rdfs:label>5beta steroid</rdfs:label>
     </owl:Class>
     
@@ -4240,6 +4341,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_138103">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_39141"/>
         <obo:IAO_0000115>A Bronsted acid derived from one or more inorganic compounds. Inorganic acids (also known as mineral acids) form hydrons and conjugate base ions when dissolved in water.</obo:IAO_0000115>
+        <obo:IAO_0000115>A Brønsted acid derived from one or more inorganic compounds. Inorganic acids (also known as mineral acids) form hydrons and conjugate base ions when dissolved in water.</obo:IAO_0000115>
         <rdfs:label>inorganic acid</rdfs:label>
     </owl:Class>
     
@@ -4251,7 +4353,7 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_25384"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35350"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_36078"/>
-        <obo:IAO_0000115>Any member of a group of hydroxy steroids occuring in bile, where they are present as the sodium salts of their amides with glycine or taurine. In mammals bile acids almost invariably have 5beta-configuration, while in lower vertebrates, some bile acids, known as allo-bile acids, have 5alpha-configuration.</obo:IAO_0000115>
+        <obo:IAO_0000115>Any member of a group of hydroxy steroids occuring in bile, where they are present as the sodium salts of their amides with glycine or taurine. In mammals bile acids almost invariably have 5β-configuration, while in lower vertebrates, some bile acids, known as &lt;i&gt;allo&lt;/i&gt;-bile acids, have 5α-configuration.</obo:IAO_0000115>
         <rdfs:label>bile acids</rdfs:label>
     </owl:Class>
     
@@ -4262,6 +4364,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_138675">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33579"/>
         <obo:IAO_0000115>Any main group molecular entity that is gaseous at standard temperature and pressure (STP; 0degreeC and 100 kPa).</obo:IAO_0000115>
+        <obo:IAO_0000115>Any main group molecular entity that is gaseous at standard temperature and pressure (STP; 0°C and 100 kPa).</obo:IAO_0000115>
         <rdfs:label>gas molecular entity</rdfs:label>
     </owl:Class>
     
@@ -4271,6 +4374,12 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_13941">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_37022"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_28616"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of"/>
@@ -4288,7 +4397,7 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_26666"/>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_78115"/>
             </owl:Restriction>
         </rdfs:subClassOf>
@@ -4308,7 +4417,7 @@ For example, A and B may be gene products and binding of B by A positively regul
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_53000"/>
             </owl:Restriction>
         </rdfs:subClassOf>
-        <obo:IAO_0000115>An antigenic epitope recognized by an anti-bilirubin monoclonal antibody designated 24G7. A substructure of bilirubin IXalpha, it is the region containing the oxo group at C-1, the methyl group at C-2, C-(4, 5, 6, 9), and N-21 and -22.</obo:IAO_0000115>
+        <obo:IAO_0000115>An antigenic epitope recognized by an anti-bilirubin monoclonal antibody designated 24G7. A substructure of bilirubin IXα, it is the region containing the oxo group at C-1, the methyl group at C-2, C-(4, 5, 6, 9), and N-21 and -22.</obo:IAO_0000115>
         <rdfs:label>24G7 epitope</rdfs:label>
     </owl:Class>
     
@@ -4326,17 +4435,17 @@ For example, A and B may be gene products and binding of B by A positively regul
         </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
-                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_29987"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_18237"/>
             </owl:Restriction>
         </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of"/>
-                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_18237"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_29987"/>
             </owl:Restriction>
         </rdfs:subClassOf>
-        <obo:IAO_0000115>An alpha-amino-acid anion that is the conjugate base of glutamic acid, having anionic carboxy groups and a cationic amino group</obo:IAO_0000115>
+        <obo:IAO_0000115>An α-amino-acid anion that is the conjugate base of glutamic acid, having anionic carboxy groups and a cationic amino group</obo:IAO_0000115>
         <rdfs:label>glutamate(1-)</rdfs:label>
     </owl:Class>
     
@@ -4427,6 +4536,12 @@ For example, A and B may be gene products and binding of B by A positively regul
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_83056"/>
             </owl:Restriction>
         </rdfs:subClassOf>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_30089"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
@@ -4439,6 +4554,19 @@ For example, A and B may be gene products and binding of B by A positively regul
     
 
 
+    <!-- http://purl.obolibrary.org/obo/CHEBI_15378 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_15378">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_25414"/>
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33251"/>
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33252"/>
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_60242"/>
+        <obo:IAO_0000115>The general name for the hydrogen nucleus, to be used without regard to the hydrogen nuclear mass (either for hydrogen in its natural abundance or where it is not desired to distinguish between the isotopes).</obo:IAO_0000115>
+        <rdfs:label>hydron</rdfs:label>
+    </owl:Class>
+    
+
+
     <!-- http://purl.obolibrary.org/obo/CHEBI_15379 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_15379">
@@ -4487,6 +4615,12 @@ For example, A and B may be gene products and binding of B by A positively regul
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_77974"/>
             </owl:Restriction>
         </rdfs:subClassOf>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_29793"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of"/>
@@ -4502,7 +4636,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_15693">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35381"/>
-        <obo:IAO_0000115>Aldehydic parent sugars (polyhydroxy aldehydes H[CH(OH)]nC(=O)H, n &gt;= 2) and their intramolecular hemiacetals.</obo:IAO_0000115>
+        <obo:IAO_0000115>Aldehydic parent sugars (polyhydroxy aldehydes H[CH(OH)]&lt;small&gt;&lt;sub&gt;&lt;em&gt;n&lt;/em&gt;&lt;/sub&gt;&lt;/small&gt;C(=O)H, &lt;em&gt;n&lt;/em&gt; ≥ 2) and their intramolecular hemiacetals.</obo:IAO_0000115>
         <rdfs:label>aldose</rdfs:label>
     </owl:Class>
     
@@ -4514,17 +4648,17 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33704"/>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_59814"/>
             </owl:Restriction>
         </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_tautomer_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018036"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_59869"/>
             </owl:Restriction>
         </rdfs:subClassOf>
-        <obo:IAO_0000115>Any alpha-amino acid having L-configuration at the alpha-carbon.</obo:IAO_0000115>
+        <obo:IAO_0000115>Any α-amino acid having &lt;small&gt;L&lt;/small&gt;-configuration at the α-carbon.</obo:IAO_0000115>
         <rdfs:label>L-alpha-amino acid</rdfs:label>
     </owl:Class>
     
@@ -4559,17 +4693,17 @@ For example, A and B may be gene products and binding of B by A positively regul
         </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_29986"/>
             </owl:Restriction>
         </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_enantiomer_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018039"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_16015"/>
             </owl:Restriction>
         </rdfs:subClassOf>
-        <obo:IAO_0000115>An optically active form of glutamic acid having D-configuration.</obo:IAO_0000115>
+        <obo:IAO_0000115>An optically active form of glutamic acid having &lt;small&gt;D&lt;/small&gt;-configuration.</obo:IAO_0000115>
         <rdfs:label>D-glutamic acid</rdfs:label>
     </owl:Class>
     
@@ -4635,17 +4769,17 @@ For example, A and B may be gene products and binding of B by A positively regul
         </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_29985"/>
             </owl:Restriction>
         </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_enantiomer_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018039"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_15966"/>
             </owl:Restriction>
         </rdfs:subClassOf>
-        <obo:IAO_0000115>An optically active form of glutamic acid having L-configuration.</obo:IAO_0000115>
+        <obo:IAO_0000115>An optically active form of glutamic acid having &lt;small&gt;L&lt;/small&gt;-configuration.</obo:IAO_0000115>
         <rdfs:label>L-glutamic acid</rdfs:label>
     </owl:Class>
     
@@ -4693,6 +4827,18 @@ For example, A and B may be gene products and binding of B by A positively regul
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_78433"/>
             </owl:Restriction>
         </rdfs:subClassOf>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_28938"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_29337"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
@@ -4735,6 +4881,12 @@ For example, A and B may be gene products and binding of B by A positively regul
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_77746"/>
             </owl:Restriction>
         </rdfs:subClassOf>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_45696"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of"/>
@@ -4758,12 +4910,19 @@ For example, A and B may be gene products and binding of B by A positively regul
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_77746"/>
             </owl:Restriction>
         </rdfs:subClassOf>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_132153"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_132153"/>
             </owl:Restriction>
         </rdfs:subClassOf>
+        <obo:IAO_0000115>A mucopolysaccharide composed of &lt;em&gt;N&lt;/em&gt;-acetylglucosamine and glucuronic acid subunits. It is found in the connective tissues of vertebrates. A principal constituent of the extracellular matrix (ECM), it mediates the growth and metastasis of tumour cells.</obo:IAO_0000115>
         <obo:IAO_0000115>A mucopolysaccharide composed of N-acetylglucosamine and glucuronic acid subunits. It is found in the connective tissues of vertebrates. A principal constituent of the extracellular matrix (ECM), it mediates the growth and metastasis of tumour cells.</obo:IAO_0000115>
         <rdfs:label>hyaluronic acid</rdfs:label>
     </owl:Class>
@@ -4790,6 +4949,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_16646">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_78616"/>
+        <obo:IAO_0000115>Any member of the class of organooxygen compounds that is a polyhydroxy-aldehyde or -ketone or a lactol resulting from their intramolecular condensation (monosaccharides); substances derived from these by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom; and polymeric products arising by intermolecular acetal formation between two or more such molecules (disaccharides, polysaccharides and oligosaccharides). Carbohydrates contain only carbon, hydrogen and oxygen atoms; prior to any oxidation or reduction, most have the empirical formula C&lt;small&gt;&lt;sub&gt;&lt;em&gt;m&lt;/em&gt;&lt;/sub&gt;&lt;/small&gt;(H&lt;small&gt;&lt;sub&gt;2&lt;/sub&gt;&lt;/small&gt;O)&lt;small&gt;&lt;sub&gt;&lt;em&gt;n&lt;/em&gt;&lt;/sub&gt;&lt;/small&gt;. Compounds obtained from carbohydrates by substitution, etc., are known as carbohydrate derivatives and may contain other elements. Cyclitols are generally not regarded as carbohydrates.</obo:IAO_0000115>
         <obo:IAO_0000115>Any member of the class of organooxygen compounds that is a polyhydroxy-aldehyde or -ketone or a lactol resulting from their intramolecular condensation (monosaccharides); substances derived from these by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom; and polymeric products arising by intermolecular acetal formation between two or more such molecules (disaccharides, polysaccharides and oligosaccharides). Carbohydrates contain only carbon, hydrogen and oxygen atoms; prior to any oxidation or reduction, most have the empirical formula Cm(H2O)n. Compounds obtained from carbohydrates by substitution, etc., are known as carbohydrate derivatives and may contain other elements. Cyclitols are generally not regarded as carbohydrates.</obo:IAO_0000115>
         <rdfs:label>carbohydrate</rdfs:label>
     </owl:Class>
@@ -4808,6 +4968,12 @@ For example, A and B may be gene products and binding of B by A positively regul
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33708"/>
             </owl:Restriction>
         </rdfs:subClassOf>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018036"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_60466"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_tautomer_of"/>
@@ -4828,10 +4994,11 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35274"/>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33569"/>
             </owl:Restriction>
         </rdfs:subClassOf>
+        <obo:IAO_0000115>An organic cation that is the conjugate acid of noradrenaline, obtained by protonation of the primary amino group; major species at pH 7.3.</obo:IAO_0000115>
         <rdfs:label>noradrenaline(1+)</rdfs:label>
     </owl:Class>
     
@@ -4843,13 +5010,13 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_83925"/>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_60895"/>
             </owl:Restriction>
         </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_tautomer_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018036"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_59871"/>
             </owl:Restriction>
         </rdfs:subClassOf>
@@ -4862,6 +5029,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_167559">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_78616"/>
+        <obo:IAO_0000115>Any oligosaccharide, polysaccharide or their derivatives consisting of monosaccharides or monosaccharide derivatives linked by glycosidic bonds. See also &lt;a href=&quot;http://www.ontobee.org/ontology/GNO?iri=http://purl.obolibrary.org/obo/GNO_00000001&quot; target=&quot;_blank&quot;&gt;http://www.ontobee.org/ontology/GNO?iri=http://purl.obolibrary.org/obo/GNO_00000001&lt;/a&gt;.</obo:IAO_0000115>
         <obo:IAO_0000115>Any oligosaccharide, polysaccharide or their derivatives consisting of monosaccharides or monosaccharide derivatives linked by glycosidic bonds. See also http://www.ontobee.org/ontology/GNO?iri=http://purl.obolibrary.org/obo/GNO_00000001.</obo:IAO_0000115>
         <rdfs:label>glycan</rdfs:label>
     </owl:Class>
@@ -4893,6 +5061,12 @@ For example, A and B may be gene products and binding of B by A positively regul
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_77746"/>
             </owl:Restriction>
         </rdfs:subClassOf>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_57887"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of"/>
@@ -4936,23 +5110,23 @@ For example, A and B may be gene products and binding of B by A positively regul
         </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#has_functional_parent"/>
-                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_30772"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_30566"/>
             </owl:Restriction>
         </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
-                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_30566"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018036"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_59888"/>
             </owl:Restriction>
         </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_tautomer_of"/>
-                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_59888"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018038"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_30772"/>
             </owl:Restriction>
         </rdfs:subClassOf>
-        <obo:IAO_0000115>A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.</obo:IAO_0000115>
+        <obo:IAO_0000115>A γ-amino acid that is butanoic acid with the amino substituent located at C-4.</obo:IAO_0000115>
         <rdfs:label>gamma-aminobutyric acid</rdfs:label>
     </owl:Class>
     
@@ -4989,7 +5163,7 @@ For example, A and B may be gene products and binding of B by A positively regul
         </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_57977"/>
             </owl:Restriction>
         </rdfs:subClassOf>
@@ -5003,7 +5177,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_17087">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_36586"/>
-        <obo:IAO_0000115>A compound in which a carbonyl group is bonded to two carbon atoms: R2C=O (neither R may be H).</obo:IAO_0000115>
+        <obo:IAO_0000115>A compound in which a carbonyl group is bonded to two carbon atoms: R&lt;small&gt;&lt;sub&gt;2&lt;/sub&gt;&lt;/small&gt;C=O (neither R may be H).</obo:IAO_0000115>
         <rdfs:label>ketone</rdfs:label>
     </owl:Class>
     
@@ -5082,14 +5256,14 @@ For example, A and B may be gene products and binding of B by A positively regul
         </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
-                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_41609"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_28976"/>
             </owl:Restriction>
         </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of"/>
-                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_28976"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_41609"/>
             </owl:Restriction>
         </rdfs:subClassOf>
         <obo:IAO_0000115>The carbon oxoanion resulting from the removal of a proton from carbonic acid.</obo:IAO_0000115>
@@ -5103,7 +5277,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_17608">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33917"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_4194"/>
-        <obo:IAO_0000115>Any D-aldose having a chain of six carbon atoms in the molecule.</obo:IAO_0000115>
+        <obo:IAO_0000115>Any &lt;small&gt;D&lt;/small&gt;-aldose having a chain of six carbon atoms in the molecule.</obo:IAO_0000115>
         <rdfs:label>D-aldohexose</rdfs:label>
     </owl:Class>
     
@@ -5114,7 +5288,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_17634">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_17234"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_17608"/>
-        <obo:IAO_0000115>A glucose with D-configuration.</obo:IAO_0000115>
+        <obo:IAO_0000115>A glucose with &lt;small&gt;D&lt;/small&gt;-configuration.</obo:IAO_0000115>
         <rdfs:label>D-glucose</rdfs:label>
     </owl:Class>
     
@@ -5158,7 +5332,7 @@ For example, A and B may be gene products and binding of B by A positively regul
         </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_30772"/>
             </owl:Restriction>
         </rdfs:subClassOf>
@@ -5229,11 +5403,11 @@ For example, A and B may be gene products and binding of B by A positively regul
         </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_14321"/>
             </owl:Restriction>
         </rdfs:subClassOf>
-        <obo:IAO_0000115>An alpha-amino acid that is glutaric acid bearing a single amino substituent at position 2.</obo:IAO_0000115>
+        <obo:IAO_0000115>An α-amino acid that is glutaric acid bearing a single amino substituent at position 2.</obo:IAO_0000115>
         <rdfs:label>glutamic acid</rdfs:label>
     </owl:Class>
     
@@ -5285,17 +5459,17 @@ For example, A and B may be gene products and binding of B by A positively regul
         </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_72587"/>
             </owl:Restriction>
         </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_enantiomer_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018039"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33571"/>
             </owl:Restriction>
         </rdfs:subClassOf>
-        <obo:IAO_0000115>The R-enantiomer of noradrenaline.</obo:IAO_0000115>
+        <obo:IAO_0000115>The &lt;i&gt;R&lt;/i&gt;-enantiomer of noradrenaline.</obo:IAO_0000115>
         <rdfs:label>(R)-noradrenaline</rdfs:label>
     </owl:Class>
     
@@ -5314,6 +5488,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_22221">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33247"/>
+        <obo:IAO_0000115>An organic group formed by removing one or more hydroxy groups from an oxoacid that has the general structure R&lt;small&gt;&lt;sub&gt;&lt;em&gt;k&lt;/em&gt;&lt;/sub&gt;&lt;/small&gt;E(=O)&lt;small&gt;&lt;sub&gt;&lt;em&gt;l&lt;/em&gt;&lt;/sub&gt;&lt;/small&gt;(OH)&lt;small&gt;&lt;sub&gt;&lt;em&gt;m&lt;/em&gt;&lt;/sub&gt;&lt;/small&gt; (&lt;em&gt;l&lt;/em&gt; ≠ 0). Although the term is almost always applied to organic compounds, with carboxylic acid as the oxoacid, acyl groups can in principle be derived from other types of acids such as sulfonic acids or phosphonic acids.</obo:IAO_0000115>
         <obo:IAO_0000115>An organic group formed by removing one or more hydroxy groups from an oxoacid that has the general structure RkE(=O)l(OH)m (l =/= 0). Although the term is almost always applied to organic compounds, with carboxylic acid as the oxoacid, acyl groups can in principle be derived from other types of acids such as sulfonic acids or phosphonic acids.</obo:IAO_0000115>
         <rdfs:label>acyl group</rdfs:label>
     </owl:Class>
@@ -5382,6 +5557,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_22695">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_51086"/>
         <obo:IAO_0000115>A molecular entity having an available pair of electrons capable of forming a covalent bond with a hydron (Bronsted base) or with the vacant orbital of some other molecular entity (Lewis base).</obo:IAO_0000115>
+        <obo:IAO_0000115>A molecular entity having an available pair of electrons capable of forming a covalent bond with a hydron (Brønsted base) or with the vacant orbital of some other molecular entity (Lewis base).</obo:IAO_0000115>
         <rdfs:label>base</rdfs:label>
     </owl:Class>
     
@@ -5404,6 +5580,7 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33232"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_51086"/>
         <obo:IAO_0000115>Any compound that produces a peak used as reference frequency in the delta chemical shift scale.</obo:IAO_0000115>
+        <obo:IAO_0000115>Any compound that produces a peak used as reference frequency in the δ chemical shift scale.</obo:IAO_0000115>
         <rdfs:label>NMR chemical shift reference compound</rdfs:label>
     </owl:Class>
     
@@ -5424,6 +5601,12 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_23004">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_27207"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018037"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_28616"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_substituent_group_from"/>
@@ -5465,6 +5648,28 @@ For example, A and B may be gene products and binding of B by A positively regul
     
 
 
+    <!-- http://purl.obolibrary.org/obo/CHEBI_234420 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_234420">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_166902"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33571"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018039"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_72587"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
+        <obo:IAO_0000115>An organic cation that is the conjugate acid of (&lt;i&gt;S&lt;/i&gt;)-noradrenaline, obtained by protonation of the primary amino group; major species at pH 7.3.</obo:IAO_0000115>
+        <rdfs:label>(S)-noradrenaline(1+)</rdfs:label>
+    </owl:Class>
+    
+
+
     <!-- http://purl.obolibrary.org/obo/CHEBI_23449 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_23449">
@@ -5510,7 +5715,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_24318">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_15705"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_83813"/>
-        <obo:IAO_0000115>An L-alpha-amino acid which is L-glutamic acid or any of the essential amino acids biosynthesised from it (glutamine, proline and arginine). A closed class.</obo:IAO_0000115>
+        <obo:IAO_0000115>An &lt;small&gt;L&lt;/small&gt;-α-amino acid which is &lt;small&gt;L&lt;/small&gt;-glutamic acid or any of the essential amino acids biosynthesised from it (glutamine, proline and arginine). A closed class.</obo:IAO_0000115>
         <rdfs:label>glutamine family amino acid</rdfs:label>
     </owl:Class>
     
@@ -5520,7 +5725,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_24319">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_76823"/>
-        <obo:IAO_0000115>An EC 6.3.* (C-N bond-forming ligase) inhibitor that interferes with the action of glutamate--ammonia ligase (EC 6.3.1.2).</obo:IAO_0000115>
+        <obo:IAO_0000115>An EC 6.3.* (&lt;em&gt;C&lt;/em&gt;‒&lt;em&gt;N&lt;/em&gt; bond-forming ligase) inhibitor that interferes with the action of glutamate—ammonia ligase (EC 6.3.1.2).</obo:IAO_0000115>
         <rdfs:label>EC 6.3.1.2 (glutamate--ammonia ligase) inhibitor</rdfs:label>
     </owl:Class>
     
@@ -5607,7 +5812,8 @@ For example, A and B may be gene products and binding of B by A positively regul
     <!-- http://purl.obolibrary.org/obo/CHEBI_24636 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_24636">
-        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_36342"/>
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_15378"/>
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33253"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/COB_0000013"/>
         <obo:IAO_0000115>Nuclear particle of charge number +1, spin 1/2 and rest mass of 1.007276470(12) u.</obo:IAO_0000115>
         <obo:IAO_0000115>Nuclear particle of charge number +1, spin ½ and rest mass of 1.007276470(12) u.</obo:IAO_0000115>
@@ -5629,6 +5835,7 @@ For example, A and B may be gene products and binding of B by A positively regul
             </owl:Restriction>
         </rdfs:subClassOf>
         <obo:IAO_0000115>Hydroxides are chemical compounds containing a hydroxy group or salts containing hydroxide (OH(-)).</obo:IAO_0000115>
+        <obo:IAO_0000115>Hydroxides are chemical compounds containing a hydroxy group or salts containing hydroxide (OH&lt;small&gt;&lt;sup&gt;−&lt;/small&gt;&lt;/sup&gt;).</obo:IAO_0000115>
         <rdfs:label>hydroxides</rdfs:label>
     </owl:Class>
     
@@ -5641,11 +5848,11 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_36248"/>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#has_functional_parent"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018038"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_36238"/>
             </owl:Restriction>
         </rdfs:subClassOf>
-        <obo:IAO_0000115>Any member of the class of 5beta-cholanic acids carrying at least one hydroxy group at unspecified position.</obo:IAO_0000115>
+        <obo:IAO_0000115>Any member of the class of 5β-cholanic acids carrying at least one hydroxy group at unspecified position.</obo:IAO_0000115>
         <rdfs:label>hydroxy-5beta-cholanic acid</rdfs:label>
     </owl:Class>
     
@@ -5717,12 +5924,6 @@ For example, A and B may be gene products and binding of B by A positively regul
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_22563"/>
             </owl:Restriction>
         </rdfs:subClassOf>
-        <rdfs:subClassOf>
-            <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
-                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_36916"/>
-            </owl:Restriction>
-        </rdfs:subClassOf>
         <obo:IAO_0000115>A salt is an assembly of cations and anions.</obo:IAO_0000115>
         <rdfs:label>salt</rdfs:label>
     </owl:Class>
@@ -5819,6 +6020,7 @@ For example, A and B may be gene products and binding of B by A positively regul
             </owl:Restriction>
         </rdfs:subClassOf>
         <obo:IAO_0000115>A group of neurotransmitters and neuromodulators that contain one amino group that is connected to an aromatic ring by ethylene group  (-CH2-CH2-). Monoamines are derived from the aromatic amino acids phenylalanine, tyrosine, histidine and tryptophan.</obo:IAO_0000115>
+        <obo:IAO_0000115>A group of neurotransmitters and neuromodulators that contain one amino group that is connected to an aromatic ring by ethylene group  (‒CH&lt;small&gt;&lt;sub&gt;2&lt;/sub&gt;&lt;/small&gt;‒CH&lt;small&gt;&lt;sub&gt;2&lt;/sub&gt;&lt;/small&gt;‒). Monoamines are derived from the aromatic amino acids phenylalanine, tyrosine, histidine and tryptophan.</obo:IAO_0000115>
         <rdfs:label>monoamine molecular messenger</rdfs:label>
     </owl:Class>
     
@@ -5828,6 +6030,12 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_25384">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33575"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35757"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
@@ -5920,6 +6128,12 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_25704">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_26820"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_58958"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
@@ -5996,7 +6210,7 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33709"/>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_tautomer_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018036"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_62031"/>
             </owl:Restriction>
         </rdfs:subClassOf>
@@ -6022,11 +6236,11 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35366"/>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_58951"/>
             </owl:Restriction>
         </rdfs:subClassOf>
-        <obo:IAO_0000115>An aliphatic monocarboxylic acid with a chain length of less than C6. If any non-hydrocarbon substituent is present, the compound is not normally regarded as a short-chain fatty acid.</obo:IAO_0000115>
+        <obo:IAO_0000115>An aliphatic monocarboxylic acid with a chain length of less than C&lt;small&gt;&lt;sub&gt;6&lt;/sub&gt;&lt;/small&gt;. If any non-hydrocarbon substituent is present, the compound is not normally regarded as a short-chain fatty acid.</obo:IAO_0000115>
         <rdfs:label>short-chain fatty acid</rdfs:label>
     </owl:Class>
     
@@ -6163,6 +6377,12 @@ For example, A and B may be gene products and binding of B by A positively regul
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35223"/>
             </owl:Restriction>
         </rdfs:subClassOf>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_45696"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
@@ -6268,7 +6488,7 @@ For example, A and B may be gene products and binding of B by A positively regul
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_76971"/>
             </owl:Restriction>
         </rdfs:subClassOf>
-        <obo:IAO_0000115>A polydisperse, highly branched glucan composed of chains of D-glucopyranose residues in alpha(1-&gt;4) glycosidic linkage, joined together by alpha(1-&gt;6) glycosidic linkages. A small number of alpha(1-&gt;3) glycosidic linkages and some cumulative alpha(1-&gt;6) links also may occur. The branches in glycogen typically contain 8 to 12 glucose residues.</obo:IAO_0000115>
+        <obo:IAO_0000115>A polydisperse, highly branched glucan composed of chains of &lt;small&gt;D&lt;/small&gt;-glucopyranose residues in α(1→4) glycosidic linkage, joined together by α(1→6) glycosidic linkages. A small number of α(1→3) glycosidic linkages and some cumulative α(1→6) links also may occur. The branches in glycogen typically contain 8 to 12 glucose residues.</obo:IAO_0000115>
         <rdfs:label>glycogen</rdfs:label>
     </owl:Class>
     
@@ -6286,6 +6506,12 @@ For example, A and B may be gene products and binding of B by A positively regul
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_76971"/>
             </owl:Restriction>
         </rdfs:subClassOf>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_13941"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
@@ -6324,6 +6550,18 @@ For example, A and B may be gene products and binding of B by A positively regul
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_77746"/>
             </owl:Restriction>
         </rdfs:subClassOf>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_350546"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018038"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_16765"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#has_functional_parent"/>
@@ -6349,7 +6587,7 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35757"/>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35366"/>
             </owl:Restriction>
         </rdfs:subClassOf>
@@ -6389,6 +6627,12 @@ For example, A and B may be gene products and binding of B by A positively regul
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_77746"/>
             </owl:Restriction>
         </rdfs:subClassOf>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_16134"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
@@ -6425,7 +6669,7 @@ For example, A and B may be gene products and binding of B by A positively regul
         </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_17544"/>
             </owl:Restriction>
         </rdfs:subClassOf>
@@ -6439,6 +6683,12 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_29067">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_25696"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35406"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33575"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of"/>
@@ -6481,6 +6731,18 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_29337">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35106"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_79389"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_16134"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_29340"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
@@ -6503,6 +6765,12 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_29340">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35106"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_79388"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_29337"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of"/>
@@ -6519,6 +6787,12 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_29793">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33693"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_15379"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
@@ -6554,23 +6828,23 @@ For example, A and B may be gene products and binding of B by A positively regul
         </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
-                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_29988"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_16015"/>
             </owl:Restriction>
         </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of"/>
-                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_16015"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_29988"/>
             </owl:Restriction>
         </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_enantiomer_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018039"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_29986"/>
             </owl:Restriction>
         </rdfs:subClassOf>
-        <obo:IAO_0000115>An alpha-amino-acid anion that is the conjugate base of L-glutamic acid, having anionic carboxy groups and a cationic amino group</obo:IAO_0000115>
+        <obo:IAO_0000115>An α-amino-acid anion that is the conjugate base of &lt;small&gt;L&lt;/small&gt;-glutamic acid, having anionic carboxy groups and a cationic amino group</obo:IAO_0000115>
         <rdfs:label>L-glutamate(1-)</rdfs:label>
     </owl:Class>
     
@@ -6582,23 +6856,23 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_14321"/>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
-                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_29989"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_15966"/>
             </owl:Restriction>
         </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of"/>
-                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_15966"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_29989"/>
             </owl:Restriction>
         </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_enantiomer_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018039"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_29985"/>
             </owl:Restriction>
         </rdfs:subClassOf>
-        <obo:IAO_0000115>An alpha-amino-acid anion that is the conjugate base of D-glutamic acid, having anionic carboxy groups and a cationic amino group</obo:IAO_0000115>
+        <obo:IAO_0000115>An α-amino-acid anion that is the conjugate base of &lt;small&gt;D&lt;/small&gt;-glutamic acid, having anionic carboxy groups and a cationic amino group</obo:IAO_0000115>
         <rdfs:label>D-glutamate(1-)</rdfs:label>
     </owl:Class>
     
@@ -6616,11 +6890,11 @@ For example, A and B may be gene products and binding of B by A positively regul
         </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_14321"/>
             </owl:Restriction>
         </rdfs:subClassOf>
-        <obo:IAO_0000115>A dicarboxylic acid dianion that is the conjugate base of glutamate(1-).</obo:IAO_0000115>
+        <obo:IAO_0000115>A dicarboxylic acid dianion that is the conjugate base of glutamate(1−).</obo:IAO_0000115>
         <rdfs:label>glutamate(2-)</rdfs:label>
     </owl:Class>
     
@@ -6633,17 +6907,17 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_59814"/>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_29985"/>
             </owl:Restriction>
         </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_enantiomer_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018039"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_29989"/>
             </owl:Restriction>
         </rdfs:subClassOf>
-        <obo:IAO_0000115>An L-alpha-amino acid anion that is the dianion obtained by the deprotonation of the both the carboxy groups of L-glutamic acid.</obo:IAO_0000115>
+        <obo:IAO_0000115>An &lt;small&gt;L&lt;/small&gt;-α-amino acid anion that is the dianion obtained by the deprotonation of the both the carboxy groups of &lt;small&gt;L&lt;/small&gt;-glutamic acid.</obo:IAO_0000115>
         <rdfs:label>L-glutamate(2-)</rdfs:label>
     </owl:Class>
     
@@ -6655,13 +6929,13 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_29987"/>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_29986"/>
             </owl:Restriction>
         </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_enantiomer_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018039"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_29988"/>
             </owl:Restriction>
         </rdfs:subClassOf>
@@ -6686,6 +6960,12 @@ For example, A and B may be gene products and binding of B by A positively regul
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_77746"/>
             </owl:Restriction>
         </rdfs:subClassOf>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_15366"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of"/>
@@ -6702,6 +6982,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_30212">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_36341"/>
+        <obo:IAO_0000115>Particle of zero charge, zero rest mass, spin quantum number 1, energy &lt;em&gt;h&lt;/em&gt;&lt;em&gt;ν&lt;/em&gt; and momentum &lt;em&gt;h&lt;/em&gt;&lt;em&gt;ν&lt;/em&gt;/&lt;em&gt;c&lt;/em&gt; (&lt;em&gt;h&lt;/em&gt; is the Planck constant, &lt;em&gt;ν&lt;/em&gt; the frequency of radiation and &lt;em&gt;c&lt;/em&gt; the speed of light), carrier of electromagnetic force.</obo:IAO_0000115>
         <obo:IAO_0000115>Particle of zero charge, zero rest mass, spin quantum number 1, energy hnu and momentum hnu/c (h is the Planck constant, nu the frequency of radiation and c the speed of light), carrier of electromagnetic force.</obo:IAO_0000115>
         <rdfs:label>photon</rdfs:label>
     </owl:Class>
@@ -6720,17 +7001,17 @@ For example, A and B may be gene products and binding of B by A positively regul
         </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#has_functional_parent"/>
-                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_17968"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_16865"/>
             </owl:Restriction>
         </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of"/>
-                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_16865"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018038"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_17968"/>
             </owl:Restriction>
         </rdfs:subClassOf>
-        <obo:IAO_0000115>An gamma-amino acid anion resulting from the deprotonation of the carboxy group of gamma-aminobutyric acid.</obo:IAO_0000115>
+        <obo:IAO_0000115>An γ-amino acid anion resulting from the deprotonation of the carboxy group of γ-aminobutyric acid.</obo:IAO_0000115>
         <rdfs:label>gamma-aminobutyrate</rdfs:label>
     </owl:Class>
     
@@ -6755,7 +7036,7 @@ For example, A and B may be gene products and binding of B by A positively regul
         </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_17968"/>
             </owl:Restriction>
         </rdfs:subClassOf>
@@ -6770,7 +7051,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_3098">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_138366"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_24663"/>
-        <obo:IAO_0000115>Any member of a group of hydroxy-5beta-cholanic acids occuring in bile, where they are present as the sodium salts of their amides with glycine or taurine. In mammals bile acids almost invariably have 5beta-configuration.</obo:IAO_0000115>
+        <obo:IAO_0000115>Any member of a group of hydroxy-5β-cholanic acids occuring in bile, where they are present as the sodium salts of their amides with glycine or taurine. In mammals bile acids almost invariably have 5β-configuration.</obo:IAO_0000115>
         <rdfs:label>bile acid</rdfs:label>
     </owl:Class>
     
@@ -6790,6 +7071,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_32988">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_51143"/>
+        <obo:IAO_0000115>An amide is a derivative of an oxoacid R&lt;small&gt;&lt;sub&gt;&lt;em&gt;k&lt;/em&gt;&lt;/sub&gt;&lt;/small&gt;E(=O)&lt;small&gt;&lt;sub&gt;&lt;em&gt;l&lt;/em&gt;&lt;/sub&gt;&lt;/small&gt;(OH)&lt;small&gt;&lt;sub&gt;&lt;em&gt;m&lt;/em&gt;&lt;/sub&gt;&lt;/small&gt; (&lt;em&gt;l&lt;/em&gt; ≠ 0) in which an acidic hydroxy group has been replaced by an amino or substituted amino group.</obo:IAO_0000115>
         <obo:IAO_0000115>An amide is a derivative of an oxoacid RkE(=O)l(OH)m (l =/= 0) in which an acidic hydroxy group has been replaced by an amino or substituted amino group.</obo:IAO_0000115>
         <rdfs:label>amide</rdfs:label>
     </owl:Class>
@@ -6830,6 +7112,12 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_33241">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_37577"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018038"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_24833"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#has_functional_parent"/>
@@ -6876,6 +7164,18 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_33247">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_24433"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_64769"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_64775"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
@@ -6908,12 +7208,6 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_33250">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_24431"/>
-        <rdfs:subClassOf>
-            <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
-                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_10545"/>
-            </owl:Restriction>
-        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
@@ -6926,6 +7220,16 @@ For example, A and B may be gene products and binding of B by A positively regul
     
 
 
+    <!-- http://purl.obolibrary.org/obo/CHEBI_33251 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_33251">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33238"/>
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33260"/>
+        <rdfs:label>monoatomic hydrogen</rdfs:label>
+    </owl:Class>
+    
+
+
     <!-- http://purl.obolibrary.org/obo/CHEBI_33252 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_33252">
@@ -6957,6 +7261,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_33256">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_32988"/>
+        <obo:IAO_0000115>A derivative of an oxoacid R&lt;small&gt;&lt;sub&gt;&lt;em&gt;k&lt;/em&gt;&lt;/sub&gt;&lt;/small&gt;E(=O)&lt;small&gt;&lt;sub&gt;&lt;em&gt;l&lt;/em&gt;&lt;/sub&gt;&lt;/small&gt;(OH)&lt;small&gt;&lt;sub&gt;&lt;em&gt;m&lt;/em&gt;&lt;/sub&gt;&lt;/small&gt; (&lt;em&gt;l&lt;/em&gt; ≠ 0) in which an acidic hydroxy group has been replaced by an amino or substituted amino group.</obo:IAO_0000115>
         <obo:IAO_0000115>A derivative of an oxoacid RkE(=O)l(OH)m (l =/= 0) in which an acidic hydroxy group has been replaced by an amino or substituted amino group.</obo:IAO_0000115>
         <rdfs:label>primary amide</rdfs:label>
     </owl:Class>
@@ -6973,6 +7278,17 @@ For example, A and B may be gene products and binding of B by A positively regul
     
 
 
+    <!-- http://purl.obolibrary.org/obo/CHEBI_33260 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_33260">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_24835"/>
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33259"/>
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33608"/>
+        <rdfs:label>elemental hydrogen</rdfs:label>
+    </owl:Class>
+    
+
+
     <!-- http://purl.obolibrary.org/obo/CHEBI_33262 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_33262">
@@ -7126,6 +7442,7 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35701"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_36586"/>
         <obo:IAO_0000115>An ester of a carboxylic acid, R(1)C(=O)OR(2), where R(1) = H or organyl and R(2) = organyl.</obo:IAO_0000115>
+        <obo:IAO_0000115>An ester of a carboxylic acid, R&lt;small&gt;&lt;sup&gt;1&lt;/small&gt;&lt;/sup&gt;C(=O)OR&lt;small&gt;&lt;sup&gt;2&lt;/small&gt;&lt;/sup&gt;, where R&lt;small&gt;&lt;sup&gt;1&lt;/small&gt;&lt;/sup&gt; = H or organyl and R&lt;small&gt;&lt;sup&gt;2&lt;/small&gt;&lt;/sup&gt; = organyl.</obo:IAO_0000115>
         <rdfs:label>carboxylic ester</rdfs:label>
     </owl:Class>
     
@@ -7218,6 +7535,12 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_33558">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_37022"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33704"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of"/>
@@ -7225,6 +7548,7 @@ For example, A and B may be gene products and binding of B by A positively regul
             </owl:Restriction>
         </rdfs:subClassOf>
         <obo:IAO_0000115>An amino-acid anion obtained by deprotonation of any alpha-amino acid.</obo:IAO_0000115>
+        <obo:IAO_0000115>An amino-acid anion obtained by deprotonation of any α-amino acid.</obo:IAO_0000115>
         <rdfs:label>alpha-amino-acid anion</rdfs:label>
     </owl:Class>
     
@@ -7253,7 +7577,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_33566">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33570"/>
-        <obo:IAO_0000115>Any compound containing an o-diphenol component.</obo:IAO_0000115>
+        <obo:IAO_0000115>Any compound containing an &lt;em&gt;o&lt;/em&gt;-diphenol component.</obo:IAO_0000115>
         <rdfs:label>catechols</rdfs:label>
     </owl:Class>
     
@@ -7282,7 +7606,7 @@ For example, A and B may be gene products and binding of B by A positively regul
         </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_166902"/>
             </owl:Restriction>
         </rdfs:subClassOf>
@@ -7307,11 +7631,17 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33569"/>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_enantiomer_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_234420"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018039"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_18357"/>
             </owl:Restriction>
         </rdfs:subClassOf>
-        <obo:IAO_0000115>The S-enantiomer of noradrenaline.</obo:IAO_0000115>
+        <obo:IAO_0000115>The &lt;i&gt;S&lt;/i&gt;-enantiomer of noradrenaline.</obo:IAO_0000115>
         <rdfs:label>(S)-noradrenaline</rdfs:label>
     </owl:Class>
     
@@ -7329,6 +7659,12 @@ For example, A and B may be gene products and binding of B by A positively regul
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_46883"/>
             </owl:Restriction>
         </rdfs:subClassOf>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_29067"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
@@ -7336,6 +7672,7 @@ For example, A and B may be gene products and binding of B by A positively regul
             </owl:Restriction>
         </rdfs:subClassOf>
         <obo:IAO_0000115>A carbon oxoacid acid carrying at least one -C(=O)OH group and having the structure RC(=O)OH, where R is any any monovalent functional group. Carboxylic acids are the most common type of organic acid.</obo:IAO_0000115>
+        <obo:IAO_0000115>A carbon oxoacid acid carrying at least one ‒C(=O)OH group and having the structure RC(=O)OH, where R is any any monovalent functional group. Carboxylic acids are the most common type of organic acid.</obo:IAO_0000115>
         <rdfs:label>carboxylic acid</rdfs:label>
     </owl:Class>
     
@@ -7386,12 +7723,6 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_33608">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33674"/>
-        <rdfs:subClassOf>
-            <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
-                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_49637"/>
-            </owl:Restriction>
-        </rdfs:subClassOf>
         <rdfs:label>hydrogen molecular entity</rdfs:label>
     </owl:Class>
     
@@ -7421,6 +7752,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_33655">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33595"/>
         <obo:IAO_0000115>A cyclically conjugated molecular entity with a stability (due to delocalization) significantly greater than that of a hypothetical localized structure (e.g. Kekule structure) is said to possess aromatic character.</obo:IAO_0000115>
+        <obo:IAO_0000115>A cyclically conjugated molecular entity with a stability (due to delocalization) significantly greater than that of a hypothetical localized structure (e.g. Kekulé structure) is said to possess aromatic character.</obo:IAO_0000115>
         <rdfs:label>aromatic compound</rdfs:label>
     </owl:Class>
     
@@ -7462,12 +7794,6 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_33674">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33579"/>
-        <rdfs:subClassOf>
-            <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
-                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33559"/>
-            </owl:Restriction>
-        </rdfs:subClassOf>
         <obo:IAO_0000115>An s-block molecular entity is a molecular entity containing one or more atoms of an s-block element.</obo:IAO_0000115>
         <rdfs:label>s-block molecular entity</rdfs:label>
     </owl:Class>
@@ -7546,6 +7872,7 @@ For example, A and B may be gene products and binding of B by A positively regul
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_50297"/>
             </owl:Restriction>
         </rdfs:subClassOf>
+        <obo:IAO_0000115>A macromolecule made up of nucleotide units and hydrolysable into certain pyrimidine or purine bases (usually adenine, cytosine, guanine, thymine, uracil), &lt;small&gt;D&lt;/small&gt;-ribose or 2-deoxy-&lt;small&gt;D&lt;/small&gt;-ribose and phosphoric acid.</obo:IAO_0000115>
         <obo:IAO_0000115>A macromolecule made up of nucleotide units and hydrolysable into certain pyrimidine or purine bases (usually adenine, cytosine, guanine, thymine, uracil), D-ribose or 2-deoxy-D-ribose and phosphoric acid.</obo:IAO_0000115>
         <rdfs:label>nucleic acid</rdfs:label>
     </owl:Class>
@@ -7599,6 +7926,12 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_33703">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_25697"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33702"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33709"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
@@ -7614,6 +7947,24 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_33704">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33709"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33719"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33558"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018036"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_78608"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
@@ -7633,6 +7984,7 @@ For example, A and B may be gene products and binding of B by A positively regul
             </owl:Restriction>
         </rdfs:subClassOf>
         <obo:IAO_0000115>An amino acid in which the amino group is located on the carbon atom at the position alpha to the carboxy group.</obo:IAO_0000115>
+        <obo:IAO_0000115>An amino acid in which the amino group is located on the carbon atom at the position α to the carboxy group.</obo:IAO_0000115>
         <rdfs:label>alpha-amino acid</rdfs:label>
     </owl:Class>
     
@@ -7644,11 +7996,11 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_83820"/>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_71666"/>
             </owl:Restriction>
         </rdfs:subClassOf>
-        <obo:IAO_0000115>A non-proteinogenic amino-acid in which the amino group is located on the carbon atom at the position gamma to the carboxy group.</obo:IAO_0000115>
+        <obo:IAO_0000115>A non-proteinogenic amino-acid in which the amino group is located on the carbon atom at the position γ to the carboxy group.</obo:IAO_0000115>
         <rdfs:label>gamma-amino acid</rdfs:label>
     </owl:Class>
     
@@ -7658,6 +8010,24 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_33708">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33247"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_58942"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_64898"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018037"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33709"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
@@ -7687,6 +8057,18 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_33709">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33575"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_50047"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33703"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_37022"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
@@ -7709,6 +8091,12 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_33710">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33708"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018037"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33704"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_substituent_group_from"/>
@@ -7716,6 +8104,7 @@ For example, A and B may be gene products and binding of B by A positively regul
             </owl:Restriction>
         </rdfs:subClassOf>
         <obo:IAO_0000115>An amino-acid residue derived from an alpha-amino acid.</obo:IAO_0000115>
+        <obo:IAO_0000115>An amino-acid residue derived from an α-amino acid.</obo:IAO_0000115>
         <rdfs:label>alpha-amino-acid residue</rdfs:label>
     </owl:Class>
     
@@ -7725,6 +8114,12 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_33719">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33703"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33704"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
@@ -7741,6 +8136,12 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_33720">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_16646"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33575"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33721"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
@@ -7756,6 +8157,12 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_33721">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_29067"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33720"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of"/>
@@ -7813,6 +8220,7 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_24532"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33659"/>
         <obo:IAO_0000115>A heterocyclic compound formally derived from an arene by replacement of one or more methine (-C=) and/or vinylene (-CH=CH-) groups by trivalent or divalent heteroatoms, respectively, in such a way as to maintain the continuous pi-electron system characteristic of aromatic systems and a number of out-of-plane pi-electrons corresponding to the Hueckel rule (4n+2).</obo:IAO_0000115>
+        <obo:IAO_0000115>A heterocyclic compound formally derived from an arene by replacement of one or more methine (‒C=) and/or vinylene (‒CH=CH‒) groups by trivalent or divalent heteroatoms, respectively, in such a way as to maintain the continuous π-electron system characteristic of aromatic systems and a number of out-of-plane π-electrons corresponding to the Hückel rule (4&lt;em&gt;n&lt;/em&gt;+2).</obo:IAO_0000115>
         <rdfs:label>heteroarene</rdfs:label>
     </owl:Class>
     
@@ -7893,6 +8301,12 @@ For example, A and B may be gene products and binding of B by A positively regul
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_77746"/>
             </owl:Restriction>
         </rdfs:subClassOf>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_28790"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
@@ -7919,6 +8333,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_35107">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35106"/>
+        <obo:IAO_0000115>Saturated acyclic nitrogen hydrides having the general formula N&lt;small&gt;&lt;sub&gt;&lt;em&gt;n&lt;/em&gt;&lt;/sub&gt;&lt;/small&gt;H&lt;small&gt;&lt;sub&gt;&lt;em&gt;n&lt;/em&gt;+2&lt;/sub&gt;&lt;/small&gt;.</obo:IAO_0000115>
         <obo:IAO_0000115>Saturated acyclic nitrogen hydrides having the general formula NnHn+2.</obo:IAO_0000115>
         <rdfs:label>azane</rdfs:label>
     </owl:Class>
@@ -7961,6 +8376,7 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_25697"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35274"/>
         <obo:IAO_0000115>A derivative of ammonium, NH4(+), in which all four of the hydrogens bonded to nitrogen have been replaced with univalent (usually organyl) groups.</obo:IAO_0000115>
+        <obo:IAO_0000115>A derivative of ammonium, NH&lt;small&gt;&lt;sub&gt;4&lt;/sub&gt;&lt;/small&gt;&lt;small&gt;&lt;sup&gt;+&lt;/small&gt;&lt;/sup&gt;, in which all four of the hydrogens bonded to nitrogen have been replaced with univalent (usually organyl) groups.</obo:IAO_0000115>
         <rdfs:label>quaternary ammonium ion</rdfs:label>
     </owl:Class>
     
@@ -7971,6 +8387,12 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_35274">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33702"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_51143"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018040"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_28938"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#has_parent_hydride"/>
@@ -7978,6 +8400,7 @@ For example, A and B may be gene products and binding of B by A positively regul
             </owl:Restriction>
         </rdfs:subClassOf>
         <obo:IAO_0000115>A derivative of ammonium, NH4(+), in which one (or more) of the hydrogens bonded to the nitrogen have been replaced with univalent organyl groups. The substituting carbon of the organyl group must not itself be directly attached to a heteroatom (thereby excluding protonated amides, hemiaminals, etc).</obo:IAO_0000115>
+        <obo:IAO_0000115>A derivative of ammonium, NH&lt;small&gt;&lt;sub&gt;4&lt;/sub&gt;&lt;/small&gt;&lt;small&gt;&lt;sup&gt;+&lt;/small&gt;&lt;/sup&gt;, in which one (or more) of the hydrogens bonded to the nitrogen have been replaced with univalent organyl groups. The substituting carbon of the organyl group must not itself be directly attached to a heteroatom (thereby excluding protonated amides, hemiaminals, etc).</obo:IAO_0000115>
         <rdfs:label>ammonium ion derivative</rdfs:label>
     </owl:Class>
     
@@ -7998,6 +8421,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_35341">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_18059"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_51958"/>
+        <obo:IAO_0000115>Any of naturally occurring compounds and synthetic analogues, based on the cyclopenta[&lt;em&gt;a&lt;/em&gt;]phenanthrene carbon skeleton, partially or completely hydrogenated; there are usually methyl groups at C-10 and C-13, and often an alkyl group at C-17. By extension, one or more bond scissions, ring expansions and/or ring contractions of the skeleton may have occurred. Natural steroids are derived biogenetically from squalene which is a triterpene.</obo:IAO_0000115>
         <obo:IAO_0000115>Any of naturally occurring compounds and synthetic analogues, based on the cyclopenta[a]phenanthrene carbon skeleton, partially or completely hydrogenated; there are usually methyl groups at C-10 and C-13, and often an alkyl group at C-17. By extension, one or more bond scissions, ring expansions and/or ring contractions of the skeleton may have occurred. Natural steroids are derived biogenetically from squalene which is a triterpene.</obo:IAO_0000115>
         <rdfs:label>steroid</rdfs:label>
     </owl:Class>
@@ -8032,7 +8456,7 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_25384"/>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_28868"/>
             </owl:Restriction>
         </rdfs:subClassOf>
@@ -8046,7 +8470,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_35381">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_16646"/>
-        <obo:IAO_0000115>Parent monosaccharides are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H-[CHOH]n-C(=O)[CHOH]m-H with three or more carbon atoms. The generic term &apos;monosaccharide&apos; (as opposed to oligosaccharide or polysaccharide) denotes a single unit, without glycosidic connection to other such units. It includes aldoses, dialdoses, aldoketoses, ketoses and diketoses, as well as deoxy sugars, provided that the parent compound has a (potential) carbonyl group.</obo:IAO_0000115>
+        <obo:IAO_0000115>Parent monosaccharides are polyhydroxy aldehydes H[CH(OH)]&lt;small&gt;&lt;sub&gt;&lt;em&gt;n&lt;/em&gt;&lt;/sub&gt;&lt;/small&gt;C(=O)H or polyhydroxy ketones H‒[CHOH]&lt;small&gt;&lt;sub&gt;&lt;em&gt;n&lt;/em&gt;&lt;/sub&gt;&lt;/small&gt;‒C(=O)[CHOH]&lt;small&gt;&lt;sub&gt;&lt;em&gt;m&lt;/em&gt;&lt;/sub&gt;&lt;/small&gt;‒H with three or more carbon atoms. The generic term &apos;monosaccharide&apos; (as opposed to oligosaccharide or polysaccharide) denotes a single unit, without glycosidic connection to other such units. It includes aldoses, dialdoses, aldoketoses, ketoses and diketoses, as well as deoxy sugars, provided that the parent compound has a (potential) carbonyl group.</obo:IAO_0000115>
         <rdfs:label>monosaccharide</rdfs:label>
     </owl:Class>
     
@@ -8137,7 +8561,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_35569">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_37886"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_48539"/>
-        <obo:IAO_0000115>An agent that selectively binds to and activates alpha-adrenergic receptors.</obo:IAO_0000115>
+        <obo:IAO_0000115>An agent that selectively binds to and activates α-adrenergic receptors.</obo:IAO_0000115>
         <rdfs:label>alpha-adrenergic agonist</rdfs:label>
     </owl:Class>
     
@@ -8149,7 +8573,7 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_25696"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35406"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_36963"/>
-        <obo:IAO_0000115>A negative ion consisting solely of carbon and oxygen  atoms, and therefore having the general formula CxOy(n-) for some integers x, y and n.</obo:IAO_0000115>
+        <obo:IAO_0000115>A negative ion consisting solely of carbon and oxygen  atoms, and therefore having the general formula C&lt;small&gt;&lt;sub&gt;&lt;em&gt;x&lt;/em&gt;&lt;/sub&gt;&lt;/small&gt;O&lt;small&gt;&lt;sub&gt;&lt;em&gt;y&lt;/em&gt;&lt;/sub&gt;&lt;/small&gt;&lt;small&gt;&lt;sup&gt;&lt;em&gt;n&lt;/em&gt;−&lt;/small&gt;&lt;/sup&gt; for some integers &lt;em&gt;x&lt;/em&gt;, &lt;em&gt;y&lt;/em&gt; and &lt;em&gt;n&lt;/em&gt;.</obo:IAO_0000115>
         <rdfs:label>carbon oxoanion</rdfs:label>
     </owl:Class>
     
@@ -8182,7 +8606,7 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33575"/>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35693"/>
             </owl:Restriction>
         </rdfs:subClassOf>
@@ -8198,7 +8622,7 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_29067"/>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35692"/>
             </owl:Restriction>
         </rdfs:subClassOf>
@@ -8211,6 +8635,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_35701">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_36963"/>
+        <obo:IAO_0000115>A compound formally derived from an oxoacid R&lt;small&gt;&lt;sub&gt;&lt;em&gt;k&lt;/em&gt;&lt;/sub&gt;&lt;/small&gt;E(=O)&lt;small&gt;&lt;sub&gt;&lt;em&gt;l&lt;/em&gt;&lt;/sub&gt;&lt;/small&gt;(OH)&lt;small&gt;&lt;sub&gt;&lt;em&gt;m&lt;/em&gt;&lt;/sub&gt;&lt;/small&gt; (&lt;em&gt;l&lt;/em&gt; &gt; 0) and an alcohol, phenol, heteroarenol, or enol by linking with formal loss of water from an acidic hydroxy group of the former and a hydroxy group of the latter.</obo:IAO_0000115>
         <obo:IAO_0000115>A compound formally derived from an oxoacid RkE(=O)l(OH)m (l &gt; 0) and an alcohol, phenol, heteroarenol, or enol by linking with formal loss of water from an acidic hydroxy group of the former and a hydroxy group of the latter.</obo:IAO_0000115>
         <rdfs:label>ester</rdfs:label>
     </owl:Class>
@@ -8242,6 +8667,12 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_35757">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_29067"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_25384"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of"/>
@@ -8281,7 +8712,7 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35341"/>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#has_parent_hydride"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018040"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35519"/>
             </owl:Restriction>
         </rdfs:subClassOf>
@@ -8347,11 +8778,11 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_36278"/>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#has_parent_hydride"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018040"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_20664"/>
             </owl:Restriction>
         </rdfs:subClassOf>
-        <obo:IAO_0000115>Members of the class of cholanic acids based on a 5beta-cholane skeleton.</obo:IAO_0000115>
+        <obo:IAO_0000115>Members of the class of cholanic acids based on a 5β-cholane skeleton.</obo:IAO_0000115>
         <rdfs:label>5beta-cholanic acids</rdfs:label>
     </owl:Class>
     
@@ -8384,6 +8815,7 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33233"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_36340"/>
         <obo:IAO_0000115>Lepton is a fermion that does not experience the strong force (strong interaction). The term is derived from the Greek lambdaepsilonpitauomicronsigma (small, thin).</obo:IAO_0000115>
+        <obo:IAO_0000115>Lepton is a fermion that does not experience the strong force (strong interaction). The term is derived from the Greek λεπτοσ (small, thin).</obo:IAO_0000115>
         <rdfs:label>lepton</rdfs:label>
     </owl:Class>
     
@@ -8395,6 +8827,7 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_36340"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_36344"/>
         <obo:IAO_0000115>Baryon is a fermion that does experience the strong force (strong interaction). The term is derived from the Greek betaalpharhoupsilonsigma (heavy).</obo:IAO_0000115>
+        <obo:IAO_0000115>Baryon is a fermion that does experience the strong force (strong interaction). The term is derived from the Greek βαρυσ (heavy).</obo:IAO_0000115>
         <rdfs:label>baryon</rdfs:label>
     </owl:Class>
     
@@ -8607,6 +9040,12 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_37022">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_29067"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35352"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33709"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of"/>
@@ -8680,6 +9119,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_37527">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_51086"/>
         <obo:IAO_0000115>An acid is a molecular entity capable of donating a hydron (Bronsted acid) or capable of forming a covalent bond with an electron pair (Lewis acid).</obo:IAO_0000115>
+        <obo:IAO_0000115>An acid is a molecular entity capable of donating a hydron (Brønsted acid) or capable of forming a covalent bond with an electron pair (Lewis acid).</obo:IAO_0000115>
         <rdfs:label>acid</rdfs:label>
     </owl:Class>
     
@@ -8708,6 +9148,7 @@ For example, A and B may be gene products and binding of B by A positively regul
             </owl:Restriction>
         </rdfs:subClassOf>
         <obo:IAO_0000115>An amide of a carboxylic acid, having the structure RC(=O)NR2. The term is used as a suffix in systematic name formation to denote the -C(=O)NH2 group including its carbon atom.</obo:IAO_0000115>
+        <obo:IAO_0000115>An amide of a carboxylic acid, having the structure RC(=O)NR&lt;small&gt;&lt;sub&gt;2&lt;/sub&gt;&lt;/small&gt;. The term is used as a suffix in systematic name formation to denote the ‒C(=O)NH&lt;small&gt;&lt;sub&gt;2&lt;/sub&gt;&lt;/small&gt; group including its carbon atom.</obo:IAO_0000115>
         <rdfs:label>carboxamide</rdfs:label>
     </owl:Class>
     
@@ -8726,6 +9167,12 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_37826">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33424"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018038"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_26836"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#has_functional_parent"/>
@@ -8741,6 +9188,12 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_37838">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_22221"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018037"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33575"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_substituent_group_from"/>
@@ -8894,6 +9347,7 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_17891"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_37527"/>
         <obo:IAO_0000115>A molecular entity capable of donating a hydron to an acceptor (Bronsted base).</obo:IAO_0000115>
+        <obo:IAO_0000115>A molecular entity capable of donating a hydron to an acceptor (Brønsted base).</obo:IAO_0000115>
         <rdfs:label>Bronsted acid</rdfs:label>
     </owl:Class>
     
@@ -8905,6 +9359,7 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_15339"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_22695"/>
         <obo:IAO_0000115>A molecular entity capable of accepting a hydron from a donor (Bronsted acid).</obo:IAO_0000115>
+        <obo:IAO_0000115>A molecular entity capable of accepting a hydron from a donor (Brønsted acid).</obo:IAO_0000115>
         <rdfs:label>Bronsted base</rdfs:label>
     </owl:Class>
     
@@ -8928,7 +9383,7 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_59202"/>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_58954"/>
             </owl:Restriction>
         </rdfs:subClassOf>
@@ -8944,7 +9399,7 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35604"/>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_17544"/>
             </owl:Restriction>
         </rdfs:subClassOf>
@@ -8982,7 +9437,7 @@ For example, A and B may be gene products and binding of B by A positively regul
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_77746"/>
             </owl:Restriction>
         </rdfs:subClassOf>
-        <obo:IAO_0000115>A glucopyranose having D-configuration.</obo:IAO_0000115>
+        <obo:IAO_0000115>A glucopyranose having &lt;small&gt;D&lt;/small&gt;-configuration.</obo:IAO_0000115>
         <rdfs:label>D-glucopyranose</rdfs:label>
     </owl:Class>
     
@@ -8992,7 +9447,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_4194">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_18133"/>
-        <obo:IAO_0000115>A hexose that has D-configuration at position 5.</obo:IAO_0000115>
+        <obo:IAO_0000115>A hexose that has &lt;small&gt;D&lt;/small&gt;-configuration at position 5.</obo:IAO_0000115>
         <rdfs:label>D-hexose</rdfs:label>
     </owl:Class>
     
@@ -9011,6 +9466,18 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_45696">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33482"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_26836"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_16189"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
@@ -9061,6 +9528,12 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_47622">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33308"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018038"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_15366"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#has_functional_parent"/>
@@ -9080,7 +9553,7 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_64709"/>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_50160"/>
             </owl:Restriction>
         </rdfs:subClassOf>
@@ -9125,7 +9598,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_48539">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_37962"/>
-        <obo:IAO_0000115>Any drug that acts on an alpha-adrenergic receptor.</obo:IAO_0000115>
+        <obo:IAO_0000115>Any drug that acts on an α-adrenergic receptor.</obo:IAO_0000115>
         <rdfs:label>alpha-adrenergic drug</rdfs:label>
     </owl:Class>
     
@@ -9168,6 +9641,12 @@ For example, A and B may be gene products and binding of B by A positively regul
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_39142"/>
             </owl:Restriction>
         </rdfs:subClassOf>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018040"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_16134"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#has_parent_hydride"/>
@@ -9186,7 +9665,7 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_29067"/>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_47891"/>
             </owl:Restriction>
         </rdfs:subClassOf>
@@ -9330,6 +9809,12 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_50994">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_50047"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_65296"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of"/>
@@ -9449,6 +9934,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_52211">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_24432"/>
+        <obo:IAO_0000115>A biological role relating to the normal mechanisms and their interactions within a living system.</obo:IAO_0000115>
         <rdfs:label>physiological role</rdfs:label>
     </owl:Class>
     
@@ -9546,6 +10032,12 @@ For example, A and B may be gene products and binding of B by A positively regul
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_77746"/>
             </owl:Restriction>
         </rdfs:subClassOf>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_16765"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
@@ -9571,7 +10063,7 @@ For example, A and B may be gene products and binding of B by A positively regul
         </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_16990"/>
             </owl:Restriction>
         </rdfs:subClassOf>
@@ -9585,6 +10077,12 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_58942">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_64769"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33708"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
@@ -9603,11 +10101,11 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_28868"/>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_26666"/>
             </owl:Restriction>
         </rdfs:subClassOf>
-        <obo:IAO_0000115>Any fatty acid anion obtained by removal of a proton from the carboxy group of a short-chain fatty acid (chain length of less than C6).</obo:IAO_0000115>
+        <obo:IAO_0000115>Any fatty acid anion obtained by removal of a proton from the carboxy group of a short-chain fatty acid (chain length of less than C&lt;small&gt;&lt;sub&gt;6&lt;/sub&gt;&lt;/small&gt;).</obo:IAO_0000115>
         <rdfs:label>short-chain fatty acid anion</rdfs:label>
     </owl:Class>
     
@@ -9617,7 +10115,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_58953">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_28868"/>
-        <obo:IAO_0000115>Any fatty acid anion in which there is no C-C unsaturation.</obo:IAO_0000115>
+        <obo:IAO_0000115>Any fatty acid anion in which there is no C‒C unsaturation.</obo:IAO_0000115>
         <rdfs:label>saturated fatty acid anion</rdfs:label>
     </owl:Class>
     
@@ -9629,7 +10127,7 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_58953"/>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_39418"/>
             </owl:Restriction>
         </rdfs:subClassOf>
@@ -9644,6 +10142,18 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_58958">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_25696"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33482"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_25704"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018038"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_16189"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#has_functional_parent"/>
@@ -9657,6 +10167,7 @@ For example, A and B may be gene products and binding of B by A positively regul
             </owl:Restriction>
         </rdfs:subClassOf>
         <obo:IAO_0000115>An organic anion of general formula RS(=O)2O(-) where R is an organyl group.</obo:IAO_0000115>
+        <obo:IAO_0000115>An organic anion of general formula RS(=O)2O(−) where R is an organyl group.</obo:IAO_0000115>
         <rdfs:label>organosulfate oxoanion</rdfs:label>
     </owl:Class>
     
@@ -9668,7 +10179,7 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35366"/>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_59203"/>
             </owl:Restriction>
         </rdfs:subClassOf>
@@ -9684,7 +10195,7 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_28868"/>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_59202"/>
             </owl:Restriction>
         </rdfs:subClassOf>
@@ -9721,11 +10232,11 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33558"/>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_15705"/>
             </owl:Restriction>
         </rdfs:subClassOf>
-        <obo:IAO_0000115>Conjugate base of an L-alpha-amino acid arising from deprotonation of the C-1 carboxy group.</obo:IAO_0000115>
+        <obo:IAO_0000115>Conjugate base of an &lt;small&gt;L&lt;/small&gt;-α-amino acid arising from deprotonation of the C-1 carboxy group.</obo:IAO_0000115>
         <rdfs:label>L-alpha-amino acid anion</rdfs:label>
     </owl:Class>
     
@@ -9737,11 +10248,11 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_78608"/>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_tautomer_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018036"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_15705"/>
             </owl:Restriction>
         </rdfs:subClassOf>
-        <obo:IAO_0000115>Zwitterionic form of an L-alpha-amino acid having an anionic carboxy group and a protonated amino group.</obo:IAO_0000115>
+        <obo:IAO_0000115>Zwitterionic form of an &lt;small&gt;L&lt;/small&gt;-α-amino acid having an anionic carboxy group and a protonated amino group.</obo:IAO_0000115>
         <rdfs:label>L-alpha-amino acid zwitterion</rdfs:label>
     </owl:Class>
     
@@ -9753,11 +10264,11 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35238"/>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_tautomer_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018036"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_16733"/>
             </owl:Restriction>
         </rdfs:subClassOf>
-        <obo:IAO_0000115>Zwitterionic form of a D-alpha-amino acid having an anionic carboxy group and a protonated amino group.</obo:IAO_0000115>
+        <obo:IAO_0000115>Zwitterionic form of a &lt;small&gt;D&lt;/small&gt;-α-amino acid having an anionic carboxy group and a protonated amino group.</obo:IAO_0000115>
         <rdfs:label>D-alpha-amino acid zwitterion</rdfs:label>
     </owl:Class>
     
@@ -9769,11 +10280,11 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35238"/>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_tautomer_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018036"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_16865"/>
             </owl:Restriction>
         </rdfs:subClassOf>
-        <obo:IAO_0000115>Zwitterionic form of gamma-aminobutyric acid having an anionic carboxy group and a protonated amino group.</obo:IAO_0000115>
+        <obo:IAO_0000115>Zwitterionic form of γ-aminobutyric acid having an anionic carboxy group and a protonated amino group.</obo:IAO_0000115>
         <rdfs:label>gamma-aminobutyric acid zwitterion</rdfs:label>
     </owl:Class>
     
@@ -9845,6 +10356,12 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_60466">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_27369"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018036"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_16670"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_tautomer_of"/>
@@ -9863,11 +10380,11 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33558"/>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_16733"/>
             </owl:Restriction>
         </rdfs:subClassOf>
-        <obo:IAO_0000115>Any alpha-amino acid anion in which the parent amino acid has D-configuration.</obo:IAO_0000115>
+        <obo:IAO_0000115>Any α-amino acid anion in which the parent amino acid has &lt;small&gt;D&lt;/small&gt;-configuration.</obo:IAO_0000115>
         <rdfs:label>D-alpha-amino acid anion</rdfs:label>
     </owl:Class>
     
@@ -9888,6 +10405,12 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_61120">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33833"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_51143"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018038"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_18282"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#has_functional_parent"/>
@@ -9922,7 +10445,7 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35238"/>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_tautomer_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018036"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_26167"/>
             </owl:Restriction>
         </rdfs:subClassOf>
@@ -9956,6 +10479,12 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_63299">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_78616"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018038"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_16646"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#has_functional_parent"/>
@@ -9972,6 +10501,18 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_63436">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_63299"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_63551"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018038"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33720"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#has_functional_parent"/>
@@ -10004,6 +10545,18 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_63551">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_29067"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_63436"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018038"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33721"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#has_functional_parent"/>
@@ -10069,6 +10622,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_64708">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_50860"/>
         <obo:IAO_0000115>An organic molecular entity containing a single carbon atom (C1).</obo:IAO_0000115>
+        <obo:IAO_0000115>An organic molecular entity containing a single carbon atom (C&lt;small&gt;&lt;sub&gt;1&lt;/sub&gt;&lt;/small&gt;).</obo:IAO_0000115>
         <rdfs:label>one-carbon compound</rdfs:label>
     </owl:Class>
     
@@ -10108,6 +10662,12 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_64769">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_64766"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33247"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
@@ -10124,6 +10684,12 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_64775">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_64767"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33247"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of"/>
@@ -10140,6 +10706,12 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_64898">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_64775"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33708"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of"/>
@@ -10168,6 +10740,12 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_167559"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33694"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_63299"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018038"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_18154"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#has_functional_parent"/>
@@ -10206,6 +10784,12 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_65296">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_25697"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35274"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_50994"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
@@ -10234,11 +10818,11 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_37022"/>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33707"/>
             </owl:Restriction>
         </rdfs:subClassOf>
-        <obo:IAO_0000115>An amino-acid anion in which the amino group is situated gamma- to the carboxylate group.</obo:IAO_0000115>
+        <obo:IAO_0000115>An amino-acid anion in which the amino group is situated γ- to the carboxylate group.</obo:IAO_0000115>
         <rdfs:label>gamma-amino acid anion</rdfs:label>
     </owl:Class>
     
@@ -10256,11 +10840,17 @@ For example, A and B may be gene products and binding of B by A positively regul
         </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_18357"/>
             </owl:Restriction>
         </rdfs:subClassOf>
-        <obo:IAO_0000115>An organic cation that is the conjugate acid of (R)-noradrenaline, obtained by protonation of the priamry amino group; major species at pH 7.3.</obo:IAO_0000115>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018039"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_234420"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
+        <obo:IAO_0000115>An organic cation that is the conjugate acid of (&lt;i&gt;R&lt;/i&gt;)-noradrenaline, obtained by protonation of the primary amino group; major species at pH 7.3.</obo:IAO_0000115>
         <rdfs:label>(R)-noradrenaline(1+)</rdfs:label>
     </owl:Class>
     
@@ -10311,7 +10901,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_75600">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_75603"/>
-        <obo:IAO_0000115>A ligase inhibitor that interferes with the action of a C-N bond-forming ligase (EC 6.3.*.*).</obo:IAO_0000115>
+        <obo:IAO_0000115>A ligase inhibitor that interferes with the action of a &lt;em&gt;C&lt;/em&gt;‒&lt;em&gt;N&lt;/em&gt; bond-forming ligase (EC 6.3.*.*).</obo:IAO_0000115>
         <rdfs:label>EC 6.3.* (C-N bond-forming ligase) inhibitor</rdfs:label>
     </owl:Class>
     
@@ -10361,6 +10951,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_75771">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_75768"/>
+        <obo:IAO_0000115>Any mammalian metabolite produced during a metabolic reaction in a mouse (&lt;em&gt;Mus musculus&lt;/em&gt;).</obo:IAO_0000115>
         <obo:IAO_0000115>Any mammalian metabolite produced during a metabolic reaction in a mouse (Mus musculus).</obo:IAO_0000115>
         <rdfs:label>mouse metabolite</rdfs:label>
     </owl:Class>
@@ -10371,6 +10962,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_75772">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_76946"/>
+        <obo:IAO_0000115>Any  fungal metabolite produced during a metabolic reaction in Baker&apos;s yeast (&lt;em&gt;Saccharomyces cerevisiae &lt;/em&gt;).</obo:IAO_0000115>
         <obo:IAO_0000115>Any  fungal metabolite produced during a metabolic reaction in Baker&apos;s yeast (Saccharomyces cerevisiae).</obo:IAO_0000115>
         <rdfs:label>Saccharomyces cerevisiae metabolite</rdfs:label>
     </owl:Class>
@@ -10431,7 +11023,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_76823">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_75600"/>
-        <obo:IAO_0000115>An EC 6.3.* (C-N bond-forming ligase) inhibitor that interferes with the action of any acid-ammonia (or amine) ligase (EC 6.3.1.*).</obo:IAO_0000115>
+        <obo:IAO_0000115>An EC 6.3.* (&lt;em&gt;C&lt;/em&gt;‒&lt;em&gt;N&lt;/em&gt; bond-forming ligase) inhibitor that interferes with the action of any acid-ammonia (or amine) ligase (EC 6.3.1.*).</obo:IAO_0000115>
         <rdfs:label>EC 6.3.1.* (acid-ammonia/amine ligase) inhibitor</rdfs:label>
     </owl:Class>
     
@@ -10482,6 +11074,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_76971">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_76969"/>
+        <obo:IAO_0000115>Any bacterial metabolite produced during a metabolic reaction in &lt;em&gt;Escherichia coli&lt;/em&gt;.</obo:IAO_0000115>
         <obo:IAO_0000115>Any bacterial metabolite produced during a metabolic reaction in Escherichia coli.</obo:IAO_0000115>
         <rdfs:label>Escherichia coli metabolite</rdfs:label>
     </owl:Class>
@@ -10492,6 +11085,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_77746">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_75768"/>
+        <obo:IAO_0000115>Any mammalian metabolite  produced during a metabolic reaction in humans (&lt;em&gt;Homo sapiens&lt;/em&gt;).</obo:IAO_0000115>
         <obo:IAO_0000115>Any mammalian metabolite  produced during a metabolic reaction in humans (Homo sapiens).</obo:IAO_0000115>
         <rdfs:label>human metabolite</rdfs:label>
     </owl:Class>
@@ -10525,7 +11119,7 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_58953"/>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_140601"/>
             </owl:Restriction>
         </rdfs:subClassOf>
@@ -10559,6 +11153,12 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_78608">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35238"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018036"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33704"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_tautomer_of"/>
@@ -10566,6 +11166,7 @@ For example, A and B may be gene products and binding of B by A positively regul
             </owl:Restriction>
         </rdfs:subClassOf>
         <obo:IAO_0000115>An amino acid-zwitterion obtained by transfer of a proton from the carboxy to the amino group of any alpha-amino acid; major species at pH 7.3.</obo:IAO_0000115>
+        <obo:IAO_0000115>An amino acid-zwitterion obtained by transfer of a proton from the carboxy to the amino group of any α-amino acid; major species at pH 7.3.</obo:IAO_0000115>
         <rdfs:label>alpha-amino-acid zwitterion</rdfs:label>
     </owl:Class>
     
@@ -10575,6 +11176,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_78616">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_36963"/>
+        <obo:IAO_0000115>Any organooxygen compound that is a polyhydroxy-aldehyde or -ketone, or a compound derived from one. Carbohydrates contain only carbon, hydrogen and oxygen and usually have an empirical formula C&lt;small&gt;&lt;sub&gt;&lt;em&gt;m&lt;/em&gt;&lt;/sub&gt;&lt;/small&gt;(H&lt;small&gt;&lt;sub&gt;2&lt;/sub&gt;&lt;/small&gt;O)&lt;small&gt;&lt;sub&gt;&lt;em&gt;n&lt;/em&gt;&lt;/sub&gt;&lt;/small&gt;; carbohydrate derivatives may contain other elements by substitution or condensation.</obo:IAO_0000115>
         <obo:IAO_0000115>Any organooxygen compound that is a polyhydroxy-aldehyde or -ketone, or a compound derived from one. Carbohydrates contain only carbon, hydrogen and oxygen and usually have an empirical formula Cm(H2O)n; carbohydrate derivatives may contain other elements by substitution or condensation.</obo:IAO_0000115>
         <rdfs:label>carbohydrates and carbohydrate derivatives</rdfs:label>
     </owl:Class>
@@ -10625,6 +11227,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_83056">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_83057"/>
+        <obo:IAO_0000115>A &lt;em&gt;Daphnia&lt;/em&gt; metabolite produced by the species &lt;em&gt;Daphnia magna&lt;/em&gt;.</obo:IAO_0000115>
         <obo:IAO_0000115>A Daphnia metabolite produced by the species Daphnia magna.</obo:IAO_0000115>
         <rdfs:label>Daphnia magna metabolite</rdfs:label>
     </owl:Class>
@@ -10635,6 +11238,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_83057">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_83039"/>
+        <obo:IAO_0000115>A crustacean metabolite produced by the genus of small planktonic arthropods, &lt;em&gt;Daphnia&lt;/em&gt;</obo:IAO_0000115>
         <obo:IAO_0000115>A crustacean metabolite produced by the genus of small planktonic arthropods, Daphnia</obo:IAO_0000115>
         <rdfs:label>Daphnia metabolite</rdfs:label>
     </owl:Class>
@@ -10645,7 +11249,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_83813">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33709"/>
-        <obo:IAO_0000115>Any of the 23 alpha-amino acids that are precursors to proteins, and are incorporated into proteins during translation. The group includes the 20 amino acids encoded by the nuclear genes of eukaryotes together with selenocysteine, pyrrolysine, and N-formylmethionine. Apart from glycine, which is non-chiral, all have L configuration.</obo:IAO_0000115>
+        <obo:IAO_0000115>Any of the 23 α-amino acids that are precursors to proteins, and are incorporated into proteins during translation. The group includes the 20 amino acids encoded by the nuclear genes of eukaryotes together with selenocysteine, pyrrolysine, and &lt;em&gt;N&lt;/em&gt;-formylmethionine. Apart from glycine, which is non-chiral, all have &lt;small&gt;L&lt;/small&gt; configuration.</obo:IAO_0000115>
         <rdfs:label>proteinogenic amino acid</rdfs:label>
     </owl:Class>
     
@@ -10666,7 +11270,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_83925">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33704"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_83820"/>
-        <obo:IAO_0000115>Any  alpha-amino acid which is not a member of the group of 23 proteinogenic amino acids.</obo:IAO_0000115>
+        <obo:IAO_0000115>Any  α-amino acid which is not a member of the group of 23 proteinogenic amino acids.</obo:IAO_0000115>
         <rdfs:label>non-proteinogenic alpha-amino acid</rdfs:label>
     </owl:Class>
     
@@ -10730,6 +11334,7 @@ For example, A and B may be gene products and binding of B by A positively regul
         <owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/GO_0031012"/>
         <owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/GO_0032991"/>
         <owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/GO_0043226"/>
+        <owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/GO_0044423"/>
         <obo:IAO_0000115>A material entity of anatomical origin (part of or deriving from an organism) that has as its parts a maximally connected cell compartment surrounded by a plasma membrane.</obo:IAO_0000115>
         <rdfs:label>cell</rdfs:label>
     </owl:Class>
@@ -12592,6 +13197,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CL_0000138">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CL_0000153"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CL_0000667"/>
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CL_0007001"/>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0001025"/>
@@ -27526,7 +28132,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000006">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s body (typically defined by its center point or a significant portion) fully enters the user-defined zone designated as &apos;Open Arm (North)&apos;. The &apos;Open Arm (North)&apos; is one of the two open arms, distinguished by its assigned &apos;north&apos; orientation or designation in the experimental setup. Unit of measure: count</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s body (typically defined by its center point or a significant portion) fully enters the user-defined zone designated as &apos;Open Arm (North)&apos;. The &apos;Open Arm (North)&apos; is one of the two open arms, distinguished by its assigned &apos;north&apos; orientation or designation in the experimental setup. Unit: count</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: open arm (north) - entries</rdfs:label>
     </owl:Class>
     
@@ -27536,7 +28142,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000007">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s body (typically defined by its center point or a significant portion) fully enters the user-defined zone designated as &apos;Open Arm (South)&apos;. The &apos;Open Arm (South)&apos; is one of the two open arms, distinguished by its assigned &apos;south&apos; orientation or designation in the experimental setup. Unit of measure: count</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s body (typically defined by its center point or a significant portion) fully enters the user-defined zone designated as &apos;Open Arm (South)&apos;. The &apos;Open Arm (South)&apos; is one of the two open arms, distinguished by its assigned &apos;south&apos; orientation or designation in the experimental setup. Unit: count</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: open arm (south) - entries</rdfs:label>
     </owl:Class>
     
@@ -27546,7 +28152,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000008">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this represents the total number of times the animal&apos;s body (typically defined by its center point or a significant portion) fully enters the designated open arm zones (e.g., &apos;Open Arm (North)&apos; and &apos;Open Arm (South)&apos;). It is a common measure of exploration and anxiety. Unit of measure: count</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this represents the total number of times the animal&apos;s body (typically defined by its center point or a significant portion) fully enters the designated open arm zones (e.g., &apos;Open Arm (North)&apos; and &apos;Open Arm (South)&apos;). It is a common measure of exploration and anxiety. Unit: count</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: open arm total entries</rdfs:label>
     </owl:Class>
     
@@ -27556,7 +28162,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000009">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s head (specifically tracked by the software) enters the user-defined &apos;Open Arm (North)&apos; zone, irrespective of full body entry. This can indicate risk assessment or tentative exploration of the arm designated as &apos;north&apos;. Unit of measure: count</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s head (specifically tracked by the software) enters the user-defined &apos;Open Arm (North)&apos; zone, irrespective of full body entry. This can indicate risk assessment or tentative exploration of the arm designated as &apos;north&apos;. Unit: count</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: open arm (north) - head entries</rdfs:label>
     </owl:Class>
     
@@ -27566,7 +28172,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000010">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s head (specifically tracked by the software) enters the user-defined &apos;Open Arm (South)&apos; zone, irrespective of full body entry, often reflecting cautious exploration of the open arm designated as &apos;south&apos;. Unit of measure: count</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s head (specifically tracked by the software) enters the user-defined &apos;Open Arm (South)&apos; zone, irrespective of full body entry, often reflecting cautious exploration of the open arm designated as &apos;south&apos;. Unit: count</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: open arm (south) - head entries</rdfs:label>
     </owl:Class>
     
@@ -27576,7 +28182,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000011">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the total number of times the animal&apos;s head (specifically tracked by the software) enters any of the designated open arm zones (e.g., &apos;Open Arm (North)&apos; and &apos;Open Arm (South)&apos;), considered an indicator of risk-assessment behavior. Unit of measure: count</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the total number of times the animal&apos;s head (specifically tracked by the software) enters any of the designated open arm zones (e.g., &apos;Open Arm (North)&apos; and &apos;Open Arm (South)&apos;), considered an indicator of risk-assessment behavior. Unit: count</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: open arm total head entries</rdfs:label>
     </owl:Class>
     
@@ -27587,7 +28193,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000012">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal&apos;s body spends within the user-defined &apos;Open Arm (North)&apos; zone. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal&apos;s body spends within the user-defined &apos;Open Arm (North)&apos; zone. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: open arm (north) - time</rdfs:label>
     </owl:Class>
     
@@ -27598,7 +28204,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000013">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal&apos;s body spends within the user-defined &apos;Open Arm (South)&apos; zone. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal&apos;s body spends within the user-defined &apos;Open Arm (South)&apos; zone. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: open arm (south) - time</rdfs:label>
     </owl:Class>
     
@@ -27609,7 +28215,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000014">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the cumulative total duration the animal&apos;s body spends within any of the designated open arm zones (e.g., &apos;Open Arm (North)&apos; and &apos;Open Arm (South)&apos;). Less time is generally indicative of higher anxiety. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the cumulative total duration the animal&apos;s body spends within any of the designated open arm zones (e.g., &apos;Open Arm (North)&apos; and &apos;Open Arm (South)&apos;). Less time is generally indicative of higher anxiety. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: open arm total time</rdfs:label>
     </owl:Class>
     
@@ -27619,7 +28225,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000015">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this represents the percentage of the total test duration that the animal spends in any of the designated open arm zones (e.g., &apos;Open Arm (North)&apos; and &apos;Open Arm (South)&apos;). Unit of measure: %</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this represents the percentage of the total test duration that the animal spends in any of the designated open arm zones (e.g., &apos;Open Arm (North)&apos; and &apos;Open Arm (South)&apos;). Unit: %</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: open arm total - percent time during test duration</rdfs:label>
     </owl:Class>
     
@@ -27630,7 +28236,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000016">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000091"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined &apos;Open Arm (North)&apos; zone. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined &apos;Open Arm (North)&apos; zone. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: open arm (north) - latency to first entry</rdfs:label>
     </owl:Class>
     
@@ -27641,7 +28247,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000017">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000091"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined &apos;Open Arm (South)&apos; zone. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined &apos;Open Arm (South)&apos; zone. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: open arm (south) - latency to first entry</rdfs:label>
     </owl:Class>
     
@@ -27652,7 +28258,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000018">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000091"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into any of the designated open arm zones (e.g., &apos;Open Arm (North)&apos; or &apos;Open Arm (South)&apos;). Longer latencies often suggest higher anxiety. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into any of the designated open arm zones (e.g., &apos;Open Arm (North)&apos; or &apos;Open Arm (South)&apos;). Longer latencies often suggest higher anxiety. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: open arm total latency to first entry</rdfs:label>
     </owl:Class>
     
@@ -27663,7 +28269,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000019">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined &apos;Open Arm (North)&apos; zone, as detected by the tracking software. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined &apos;Open Arm (North)&apos; zone, as detected by the tracking software. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: open arm (north) - time moving towards</rdfs:label>
     </owl:Class>
     
@@ -27674,7 +28280,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000020">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined &apos;Open Arm (South)&apos; zone, as detected by the tracking software. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined &apos;Open Arm (South)&apos; zone, as detected by the tracking software. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: open arm (south) - time moving towards</rdfs:label>
     </owl:Class>
     
@@ -27685,7 +28291,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000021">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the cumulative duration the animal spends actively moving towards any of the designated open arm zones (e.g., &apos;Open Arm (North)&apos; or &apos;Open Arm (South)&apos;), reflecting approach motivation. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the cumulative duration the animal spends actively moving towards any of the designated open arm zones (e.g., &apos;Open Arm (North)&apos; or &apos;Open Arm (South)&apos;), reflecting approach motivation. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: open arm total time moving towards</rdfs:label>
     </owl:Class>
     
@@ -27696,7 +28302,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000022">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior (a state of immobility except for respiratory movements) while within the user-defined &apos;Open Arm (North)&apos; zone. Freezing is a common fear response. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior (a state of immobility except for respiratory movements) while within the user-defined &apos;Open Arm (North)&apos; zone. Freezing is a common fear response. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: open arm (north) - time freezing</rdfs:label>
     </owl:Class>
     
@@ -27707,7 +28313,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000023">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined &apos;Open Arm (South)&apos; zone. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined &apos;Open Arm (South)&apos; zone. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: open arm (south) - time freezing</rdfs:label>
     </owl:Class>
     
@@ -27718,7 +28324,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000024">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the cumulative duration the animal exhibits freezing behavior while within any of the designated open arm zones (e.g., &apos;Open Arm (North)&apos; or &apos;Open Arm (South)&apos;), indicating fear or anxiety. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the cumulative duration the animal exhibits freezing behavior while within any of the designated open arm zones (e.g., &apos;Open Arm (North)&apos; or &apos;Open Arm (South)&apos;), indicating fear or anxiety. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: open arm total time freezing</rdfs:label>
     </owl:Class>
     
@@ -27728,7 +28334,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000025">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s body fully enters the user-defined &apos;Closed Arm (West)&apos; zone, representing the enclosed arm designated as &apos;west&apos;. Unit of measure: count</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s body fully enters the user-defined &apos;Closed Arm (West)&apos; zone, representing the enclosed arm designated as &apos;west&apos;. Unit: count</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: closed arm (west) - entries</rdfs:label>
     </owl:Class>
     
@@ -27738,7 +28344,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000026">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s body fully enters the user-defined &apos;Closed Arm (East)&apos; zone, representing the enclosed arm designated as &apos;east&apos;. Unit of measure: count</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s body fully enters the user-defined &apos;Closed Arm (East)&apos; zone, representing the enclosed arm designated as &apos;east&apos;. Unit: count</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: closed arm (east) - entries</rdfs:label>
     </owl:Class>
     
@@ -27748,7 +28354,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000027">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the total number of times the animal&apos;s body fully enters any of the designated closed arm zones (e.g., &apos;Closed Arm (West)&apos; and &apos;Closed Arm (East)&apos;). It is often used as an indicator of general locomotor activity. Unit of measure: count</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the total number of times the animal&apos;s body fully enters any of the designated closed arm zones (e.g., &apos;Closed Arm (West)&apos; and &apos;Closed Arm (East)&apos;). It is often used as an indicator of general locomotor activity. Unit: count</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: closed arm total entries</rdfs:label>
     </owl:Class>
     
@@ -27758,7 +28364,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000028">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s head enters the user-defined &apos;Closed Arm (West)&apos; zone. Unit of measure: count</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s head enters the user-defined &apos;Closed Arm (West)&apos; zone. Unit: count</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: closed arm (west) - head entries</rdfs:label>
     </owl:Class>
     
@@ -27768,7 +28374,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000029">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s head enters the user-defined &apos;Closed Arm (East)&apos; zone. Unit of measure: count</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s head enters the user-defined &apos;Closed Arm (East)&apos; zone. Unit: count</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: closed arm (east) - head entries</rdfs:label>
     </owl:Class>
     
@@ -27778,7 +28384,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000030">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the total number of times the animal&apos;s head enters any of the designated closed arm zones (e.g., &apos;Closed Arm (West)&apos; and &apos;Closed Arm (East)&apos;). Unit of measure: count</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the total number of times the animal&apos;s head enters any of the designated closed arm zones (e.g., &apos;Closed Arm (West)&apos; and &apos;Closed Arm (East)&apos;). Unit: count</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: closed arm total head entries</rdfs:label>
     </owl:Class>
     
@@ -27789,7 +28395,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000031">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal&apos;s body spends within the user-defined &apos;Closed Arm (West)&apos; zone. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal&apos;s body spends within the user-defined &apos;Closed Arm (West)&apos; zone. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: closed arm (west) - time</rdfs:label>
     </owl:Class>
     
@@ -27800,7 +28406,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000032">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal&apos;s body spends within the user-defined &apos;Closed Arm (East)&apos; zone. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal&apos;s body spends within the user-defined &apos;Closed Arm (East)&apos; zone. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: closed arm (east) - time</rdfs:label>
     </owl:Class>
     
@@ -27811,7 +28417,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000033">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the cumulative total duration the animal&apos;s body spends within any of the designated closed arm zones (e.g., &apos;Closed Arm (West)&apos; and &apos;Closed Arm (East)&apos;). Animals typically spend more time in these &apos;safer&apos; areas. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the cumulative total duration the animal&apos;s body spends within any of the designated closed arm zones (e.g., &apos;Closed Arm (West)&apos; and &apos;Closed Arm (East)&apos;). Animals typically spend more time in these &apos;safer&apos; areas. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: closed arm total time</rdfs:label>
     </owl:Class>
     
@@ -27821,7 +28427,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000034">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this represents the percentage of the total test duration that the animal spends in any of the designated closed arm zones (e.g., &apos;Closed Arm (West)&apos; and &apos;Closed Arm (East)&apos;). Unit of measure: %</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this represents the percentage of the total test duration that the animal spends in any of the designated closed arm zones (e.g., &apos;Closed Arm (West)&apos; and &apos;Closed Arm (East)&apos;). Unit: %</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: closed arm total - percent time during test duration</rdfs:label>
     </owl:Class>
     
@@ -27832,7 +28438,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000035">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000091"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined &apos;Closed Arm (West)&apos; zone. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined &apos;Closed Arm (West)&apos; zone. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: closed arm (west) - latency to first entry</rdfs:label>
     </owl:Class>
     
@@ -27843,7 +28449,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000036">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000091"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined &apos;Closed Arm (East)&apos; zone. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined &apos;Closed Arm (East)&apos; zone. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: closed arm (east) - latency to first entry</rdfs:label>
     </owl:Class>
     
@@ -27854,7 +28460,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000037">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000091"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into any of the designated closed arm zones (e.g., &apos;Closed Arm (West)&apos; or &apos;Closed Arm (East)&apos;). Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into any of the designated closed arm zones (e.g., &apos;Closed Arm (West)&apos; or &apos;Closed Arm (East)&apos;). Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: closed arm total latency to first entry</rdfs:label>
     </owl:Class>
     
@@ -27865,7 +28471,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000038">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined &apos;Closed Arm (West)&apos; zone. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined &apos;Closed Arm (West)&apos; zone. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: closed arm (west) - time moving towards</rdfs:label>
     </owl:Class>
     
@@ -27876,7 +28482,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000039">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined &apos;Closed Arm (East)&apos; zone. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined &apos;Closed Arm (East)&apos; zone. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: closed arm (east) - time moving towards</rdfs:label>
     </owl:Class>
     
@@ -27887,7 +28493,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000040">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the cumulative duration the animal spends actively moving towards any of the designated closed arm zones (e.g., &apos;Closed Arm (West)&apos; or &apos;Closed Arm (East)&apos;). Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the cumulative duration the animal spends actively moving towards any of the designated closed arm zones (e.g., &apos;Closed Arm (West)&apos; or &apos;Closed Arm (East)&apos;). Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: closed arm total time moving towards</rdfs:label>
     </owl:Class>
     
@@ -27898,7 +28504,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000041">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined &apos;Closed Arm (West)&apos; zone. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined &apos;Closed Arm (West)&apos; zone. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: closed arm (west) - time freezing</rdfs:label>
     </owl:Class>
     
@@ -27909,7 +28515,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000042">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined &apos;Closed Arm (East)&apos; zone. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined &apos;Closed Arm (East)&apos; zone. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: closed arm (east) - time freezing</rdfs:label>
     </owl:Class>
     
@@ -27920,7 +28526,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000043">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the cumulative duration the animal exhibits freezing behavior while within any of the designated closed arm zones (e.g., &apos;Closed Arm (West)&apos; or &apos;Closed Arm (East)&apos;). Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the cumulative duration the animal exhibits freezing behavior while within any of the designated closed arm zones (e.g., &apos;Closed Arm (West)&apos; or &apos;Closed Arm (East)&apos;). Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: closed arm total time freezing</rdfs:label>
     </owl:Class>
     
@@ -27930,7 +28536,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000044">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s body fully enters the user-defined &apos;Center&apos; zone of the maze, typically from one of the arms. The center zone is the area where all four arms meet. Unit of measure: count</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s body fully enters the user-defined &apos;Center&apos; zone of the maze, typically from one of the arms. The center zone is the area where all four arms meet. Unit: count</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: center - entries</rdfs:label>
     </owl:Class>
     
@@ -27940,7 +28546,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000045">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s head enters the user-defined &apos;Center&apos; zone of the maze. Unit of measure: count</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s head enters the user-defined &apos;Center&apos; zone of the maze. Unit: count</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: center - head entries</rdfs:label>
     </owl:Class>
     
@@ -27951,7 +28557,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000046">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal&apos;s body spends within the user-defined &apos;Center&apos; zone. Time in the center can indicate decision-making or risk assessment. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal&apos;s body spends within the user-defined &apos;Center&apos; zone. Time in the center can indicate decision-making or risk assessment. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: center - time</rdfs:label>
     </owl:Class>
     
@@ -27961,7 +28567,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000047">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this represents the percentage of the total test duration that the animal spends in the user-defined &apos;Center&apos; zone of the maze. Unit of measure: %</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this represents the percentage of the total test duration that the animal spends in the user-defined &apos;Center&apos; zone of the maze. Unit: %</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: center - percent time during test duration</rdfs:label>
     </owl:Class>
     
@@ -27972,7 +28578,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000048">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000091"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined &apos;Center&apos; zone. If the animal starts in the center, this value may be zero or not applicable. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined &apos;Center&apos; zone. If the animal starts in the center, this value may be zero or not applicable. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: center - latency to first entry</rdfs:label>
     </owl:Class>
     
@@ -27983,7 +28589,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000049">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined &apos;Center&apos; zone of the maze (e.g., from an arm). Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined &apos;Center&apos; zone of the maze (e.g., from an arm). Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: center - time moving towards</rdfs:label>
     </owl:Class>
     
@@ -27994,7 +28600,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000050">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined &apos;Center&apos; zone of the maze. Freezing in this relatively exposed area can indicate high anxiety. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined &apos;Center&apos; zone of the maze. Freezing in this relatively exposed area can indicate high anxiety. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: center - time freezing</rdfs:label>
     </owl:Class>
     
@@ -28025,7 +28631,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000053">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000004"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000162"/>
-        <obo:IAO_0000115>In the Fear-potentiated startle paradigm, this is the amplitude of the acoustic startle response (ASR) measured in response to a startle-eliciting stimulus (e.g., 95-dB white noise burst) prior to any fear conditioning procedures, typically assessed during habituation or pre-conditioning phase. This measurement serves as a reference point for later comparisons with post-conditioning startle responses. Unit of measure: arbitrary units or standardized score.</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Fear-potentiated startle paradigm, this is the amplitude of the acoustic startle response (ASR) measured in response to a startle-eliciting stimulus (e.g., 95-dB white noise burst) prior to any fear conditioning procedures, typically assessed during habituation or pre-conditioning phase. This measurement serves as a reference point for later comparisons with post-conditioning startle responses. Unit: arbitrary units or standardized score.</obo:IAO_0000115>
         <rdfs:label xml:lang="en">fear-potentiated startle: baseline acoustic startle response amplitude</rdfs:label>
     </owl:Class>
     
@@ -28076,7 +28682,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000058">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000093"/>
-        <obo:IAO_0000115>Identifier for the specific Plexiglas enclosure or sound-attenuating chamber within the Fear-Potentiated Startle (FPS) apparatus (e.g., San Diego Instruments SR-Lab) in which a subject was tested for a given trial. Unit of measure: count or identifier string</obo:IAO_0000115>
+        <obo:IAO_0000115>Identifier for the specific Plexiglas enclosure or sound-attenuating chamber within the Fear-Potentiated Startle (FPS) apparatus (e.g., San Diego Instruments SR-Lab) in which a subject was tested for a given trial. Unit: count or identifier string</obo:IAO_0000115>
         <rdfs:label xml:lang="en">fear-potentiated startle: apparatus chamber identifier</rdfs:label>
     </owl:Class>
     
@@ -28096,7 +28702,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000060">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000093"/>
-        <obo:IAO_0000115>The total number of data points (samples) recorded and analyzed for a single acoustic startle response, typically within a defined time window following stimulus onset (e.g., a 200-ms window as mentioned in the manuscript). Unit of measure: count</obo:IAO_0000115>
+        <obo:IAO_0000115>The total number of data points (samples) recorded and analyzed for a single acoustic startle response, typically within a defined time window following stimulus onset (e.g., a 200-ms window as mentioned in the manuscript). Unit: count</obo:IAO_0000115>
         <rdfs:label xml:lang="en">acoustic startle response: number of samples</rdfs:label>
     </owl:Class>
     
@@ -28106,7 +28712,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000061">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000093"/>
-        <obo:IAO_0000115>The rate at which the analog startle response signal was digitized during data acquisition. Unit of measure: Hertz (Hz)</obo:IAO_0000115>
+        <obo:IAO_0000115>The rate at which the analog startle response signal was digitized during data acquisition. Unit: Hertz (Hz)</obo:IAO_0000115>
         <rdfs:label xml:lang="en">acoustic startle response: sampling rate</rdfs:label>
     </owl:Class>
     
@@ -28117,7 +28723,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000062">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000004"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000162"/>
-        <obo:IAO_0000115>The amplitude of the digitized acoustic startle response signal at the very beginning (onset) of the defined analysis window (e.g., a 200-ms window) used to quantify the reflex. Unit of measure: millivolts (mV) or arbitrary units based on transducer calibration.</obo:IAO_0000115>
+        <obo:IAO_0000115>The amplitude of the digitized acoustic startle response signal at the very beginning (onset) of the defined analysis window (e.g., a 200-ms window) used to quantify the reflex. Unit: millivolts (mV) or arbitrary units based on transducer calibration.</obo:IAO_0000115>
         <rdfs:label xml:lang="en">acoustic startle response: startle window onset amplitude</rdfs:label>
     </owl:Class>
     
@@ -28128,7 +28734,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000063">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000004"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000162"/>
-        <obo:IAO_0000115>The peak amplitude of the acoustic startle response (e.g., &apos;jump amplitude&apos;) detected within the defined analysis window (e.g., 200-ms window) for a given trial. Unit of measure: millivolts (mV) or arbitrary units.</obo:IAO_0000115>
+        <obo:IAO_0000115>The peak amplitude of the acoustic startle response (e.g., &apos;jump amplitude&apos;) detected within the defined analysis window (e.g., 200-ms window) for a given trial. Unit: millivolts (mV) or arbitrary units.</obo:IAO_0000115>
         <rdfs:label xml:lang="en">acoustic startle response: maximum amplitude</rdfs:label>
     </owl:Class>
     
@@ -28139,7 +28745,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000064">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000004"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000091"/>
-        <obo:IAO_0000115>The latency from the onset of the startle-eliciting stimulus (or the beginning of the analysis window) to the occurrence of the maximum (peak) amplitude of the acoustic startle response. Unit of measure: milliseconds (ms)</obo:IAO_0000115>
+        <obo:IAO_0000115>The latency from the onset of the startle-eliciting stimulus (or the beginning of the analysis window) to the occurrence of the maximum (peak) amplitude of the acoustic startle response. Unit: milliseconds (ms)</obo:IAO_0000115>
         <rdfs:label xml:lang="en">acoustic startle response: time to maximum amplitude</rdfs:label>
     </owl:Class>
     
@@ -28150,7 +28756,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000065">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000004"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000162"/>
-        <obo:IAO_0000115>The average amplitude of the digitized acoustic startle response signal calculated across the entire duration of the defined analysis window (e.g., 200-ms window). Unit of measure: millivolts (mV) or arbitrary units.</obo:IAO_0000115>
+        <obo:IAO_0000115>The average amplitude of the digitized acoustic startle response signal calculated across the entire duration of the defined analysis window (e.g., 200-ms window). Unit: millivolts (mV) or arbitrary units.</obo:IAO_0000115>
         <rdfs:label xml:lang="en">acoustic startle response: average amplitude</rdfs:label>
     </owl:Class>
     
@@ -28183,7 +28789,7 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000092"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the time of the total test duration in seconds&apos;). Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the time of the total test duration in seconds&apos;). Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: test duration</rdfs:label>
     </owl:Class>
     
@@ -29313,7 +29919,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000175">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000163"/>
-        <obo:IAO_0000115>The number of seconds the individual spent freezing during a given period of time. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>The number of seconds the individual spent freezing during a given period of time. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">contextual fear conditioning: time freezing</rdfs:label>
     </owl:Class>
     
@@ -29324,7 +29930,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000176">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000163"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000164"/>
-        <obo:IAO_0000115>In the contextual fear conditioning paradigm, this is the time of the block duration in seconds. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the contextual fear conditioning paradigm, this is the time of the block duration in seconds. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">contextual fear conditioning: block duration</rdfs:label>
     </owl:Class>
     
@@ -29882,6 +30488,287 @@ For example, A and B may be gene products and binding of B by A positively regul
     
 
 
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000231 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000231">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000101"/>
+        <obo:IAO_0000115>A parameter that specifies the technical settings, environmental conditions, or experimental design of a chemotaxis assay involving Caenorhabditis elegans.</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">C. elegans chemotaxis assay parameter</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000232 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000232">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000231"/>
+        <obo:IAO_0000115>A table containing the quantities and identities of all chemicals used as a chemoattractant (e.g., isoamyl alcohol, diacetyl) to elicit a directed movement response in C. elegans.</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">C. elegans chemotaxis assay parameter: chemoattractant mixture table</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000233 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000233">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000231"/>
+        <obo:IAO_0000115>The volume of the chemoattractant mixture pipetted onto the agar plate in a chemotaxis assay. Unit: microliters (μL).</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">C. elegans chemotaxis assay parameter: chemoattractant mixture volume</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000234 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000234">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000231"/>
+        <obo:IAO_0000115>The total time elapsed from the point at which C. elegans are placed on the assay plate until the movement is arrested or the final positions are recorded. Unit: minutes.</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">C. elegans chemotaxis assay parameter: assay duration</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000235 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000235">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000100"/>
+        <obo:IAO_0000115>A quantitative or qualitative value derived from a C. elegans chemotaxis assay, typically describing the efficiency or directionality of the animals&apos; movement toward or away from a chemical source.</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">C. elegans chemotaxis assay measurement</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000236 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000236">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000235"/>
+        <obo:IAO_0000115>A behavioral measurement of chemotactic efficiency defined as the ratio of the straight-line displacement toward the attractant to the total path length traveled by the organism. Values range from -1 to 1.</obo:IAO_0000115>
+        <oboInOwl:hasExactSynonym xml:lang="en">chemotactic ratio</oboInOwl:hasExactSynonym>
+        <rdfs:label xml:lang="en">C. elegans chemotaxis assay measurement: McCutcheon index</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000237 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000237">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000235"/>
+        <obo:IAO_0000115>The average speed of a C. elegans individual or population during the duration of the chemotaxis assay. Unit: micrometers per second (µm/s).</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">C. elegans chemotaxis assay measurement: mean velocity</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000238 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000238">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000076"/>
+        <obo:IAO_0000115>A specific genetic variant or line of an organism designated by the investigator, often containing unique mutations, transgenes, or genomic edits not yet categorized in a public repository.</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">investigator-defined strain</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000239 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000239">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000238"/>
+        <obo:IAO_0000115>A specific strain of Caenorhabditis elegans, identified by its genotype or a standard nomenclature (e.g., N2, CB4856), used in experimental procedures.</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">C. elegans strain</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000240 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000240">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000239"/>
+        <obo:IAO_0000115>A C. elegans strain with the genotype daf-22 (m130). This strain was originally obtained from the Caenorhabditis Genetics Center (CGC) as strain DR476 and subsequently outcrossed three times. [Source: https://doi.org/TBD]</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">BAB9001</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000241 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000241">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000239"/>
+        <obo:IAO_0000115>A C. elegans klp-6 rescue strain with the genotype klp-6 (my8); Pklp-6::GFP::KLP-6 (array, IndEx 9002). [Source: https://doi.org/TBD]</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">BAB9002</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000242 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000242">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000239"/>
+        <obo:IAO_0000115>A C. elegans strain with the genotype cil-7 (tm5848) I, exhibiting a him phenotype. This strain was obtained from the National BioResource Project (NBRP), Japan. [Source: https://doi.org/TBD]</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">TM5848</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000243 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000243">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000239"/>
+        <obo:IAO_0000115>A C. elegans strain with the genotype cil-7 (my61[cil-7::mNG])I; him-5(e1490) V. This strain was provided as a gift from the Maureen Barr lab. [Source: https://doi.org/TBD]</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">PT3602</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000244 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000244">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000239"/>
+        <obo:IAO_0000115>A C. elegans strain with the genotype PT3602; Pnlp-43_hCaspase nZ (array IndEx 9003). [Source: https://doi.org/TBD]</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">BAB9003</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000245 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000245">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000239"/>
+        <obo:IAO_0000115>A C. elegans strain with the genotype PT3602; Pklp-6_hCaspase Cz (array IndEx 9004). [Source: https://doi.org/TBD]</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">BAB9004</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000246 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000246">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000239"/>
+        <obo:IAO_0000115>A C. elegans strain with the genotype PT3602; Pnlp-43_hCaspase nZ (array IndEx 9003) and Pklp-6_hCaspase Cz (array IndEx 9004). [Source: https://doi.org/TBD]</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">BAB9005</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000247 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000247">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000001"/>
+        <obo:IAO_0000115>fluorescence imaging measurement</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">fluorescence imaging measurement</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000248 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000248">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000247"/>
+        <obo:IAO_0000115>Mean fluorescence intensity. Unit: arbitrary units (AU)</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">mean fluorescence intensity</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000249 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000249">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000247"/>
+        <obo:IAO_0000115>A quantitative measurement of the number of distinct fluorescent spots or puncta detected within a defined region of interest in a fluorescence image. Unit: count</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">fluorescent punctal count</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000250 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000250">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000080"/>
+        <obo:IAO_0000115>A specific parameter related to fluorescence imaging acquisition or assay.</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">fluorescence imaging parameter</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000251 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000251">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000250"/>
+        <obo:IAO_0000115>fluorescence target ontology identifier</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">fluorescence target ontology identifier</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000252 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000252">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000250"/>
+        <obo:IAO_0000115>fluorescence target name</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">fluorescence target name</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000253 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000253">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/format_1929"/>
+        <obo:IAO_0000115>A .dna file format designed for storing annotated DNA sequences, including linear/circular topology, features, primers, and enzyme sites.</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">SnapGene file format</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000254 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000254">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_637912"/>
+        <obo:IAO_0000115>A preparation of Escherichia coli strain OP50 that has been rendered non-viable through the application of heat, typically used as a non-proliferating food source in C. elegans assays.</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">Escherichia coli OP50: heat-killed</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000255 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000255">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000189"/>
+        <obo:IAO_0000115>Method used to transfer C. elegans whereby an M9 buffer is used to wash C. elegans off of an agar plate. Animals can then be transferred using a piper.</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">C. elegans transfer method: M9 buffer wash</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000256 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000256">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000189"/>
+        <obo:IAO_0000115>Method used to transfer C. elegans whereby a titanium pick is used to scoop animals off of an agar plate.</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">C. elegans transfer method: titanium pick</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000257 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000257">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000129"/>
+        <obo:IAO_0000115>A video recording capturing the behavior of C. elegans during a chemotaxis assay.</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">C. elegans chemotaxis assay: video recording</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000258 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000258">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCIT_C16856"/>
+        <obo:IAO_0000115>An image or video acquired using fluorescence microscopy.</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">fluorescence imaging data</rdfs:label>
+    </owl:Class>
+    
+
+
     <!-- http://purl.obolibrary.org/obo/ENVO_00000447 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/ENVO_00000447"/>
@@ -48376,6 +49263,12 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0008150">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0003674"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <oboInOwl:hasExactSynonym>biological process</oboInOwl:hasExactSynonym>
         <oboInOwl:hasExactSynonym>physiological process</oboInOwl:hasExactSynonym>
         <rdfs:label xml:lang="en">biological process</rdfs:label>
@@ -51166,6 +52059,32 @@ For example, A and B may be gene products and binding of B by A positively regul
     
 
 
+    <!-- http://purl.obolibrary.org/obo/GO_0010155 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0010155">
+        <owl:equivalentClass>
+            <owl:Class>
+                <owl:intersectionOf rdf:parseType="Collection">
+                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/GO_0065007"/>
+                    <owl:Restriction>
+                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002211"/>
+                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_1902600"/>
+                    </owl:Restriction>
+                </owl:intersectionOf>
+            </owl:Class>
+        </owl:equivalentClass>
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_1904062"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002211"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_1902600"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
+        <rdfs:label>regulation of proton transport</rdfs:label>
+    </owl:Class>
+    
+
+
     <!-- http://purl.obolibrary.org/obo/GO_0010160 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0010160">
@@ -56875,22 +57794,27 @@ For example, A and B may be gene products and binding of B by A positively regul
     
 
 
-    <!-- http://purl.obolibrary.org/obo/GO_0014878 -->
+    <!-- http://purl.obolibrary.org/obo/GO_0014887 -->
 
-    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0014878">
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0014887">
         <owl:equivalentClass>
             <owl:Class>
                 <owl:intersectionOf rdf:parseType="Collection">
-                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/GO_0051602"/>
+                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/GO_0043500"/>
                     <owl:Restriction>
-                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
-                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0043502"/>
+                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000066"/>
+                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0001133"/>
                     </owl:Restriction>
                 </owl:intersectionOf>
             </owl:Class>
         </owl:equivalentClass>
-        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0014874"/>
-        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0051602"/>
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0014888"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000066"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0001133"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <owl:disjointWith>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002162"/>
@@ -56915,27 +57839,32 @@ For example, A and B may be gene products and binding of B by A positively regul
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_4932"/>
             </owl:Restriction>
         </owl:disjointWith>
-        <rdfs:label>response to electrical stimulus involved in regulation of muscle adaptation</rdfs:label>
+        <rdfs:label>cardiac muscle adaptation</rdfs:label>
     </owl:Class>
     
 
 
-    <!-- http://purl.obolibrary.org/obo/GO_0014879 -->
+    <!-- http://purl.obolibrary.org/obo/GO_0014888 -->
 
-    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0014879">
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0014888">
         <owl:equivalentClass>
             <owl:Class>
                 <owl:intersectionOf rdf:parseType="Collection">
-                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/GO_0050981"/>
+                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/GO_0043500"/>
                     <owl:Restriction>
-                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
-                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0043502"/>
+                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000066"/>
+                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0002036"/>
                     </owl:Restriction>
                 </owl:intersectionOf>
             </owl:Class>
         </owl:equivalentClass>
-        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0014878"/>
-        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0050981"/>
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0043500"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000066"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0002036"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <owl:disjointWith>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002162"/>
@@ -56960,32 +57889,27 @@ For example, A and B may be gene products and binding of B by A positively regul
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_4932"/>
             </owl:Restriction>
         </owl:disjointWith>
-        <rdfs:label>detection of electrical stimulus involved in regulation of muscle adaptation</rdfs:label>
+        <rdfs:label>striated muscle adaptation</rdfs:label>
     </owl:Class>
     
 
 
-    <!-- http://purl.obolibrary.org/obo/GO_0014887 -->
+    <!-- http://purl.obolibrary.org/obo/GO_0014895 -->
 
-    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0014887">
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0014895">
         <owl:equivalentClass>
             <owl:Class>
                 <owl:intersectionOf rdf:parseType="Collection">
-                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/GO_0043500"/>
+                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/GO_0014896"/>
                     <owl:Restriction>
                         <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000066"/>
-                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0001133"/>
+                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0001135"/>
                     </owl:Restriction>
                 </owl:intersectionOf>
             </owl:Class>
         </owl:equivalentClass>
-        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0014888"/>
-        <rdfs:subClassOf>
-            <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000066"/>
-                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0001133"/>
-            </owl:Restriction>
-        </rdfs:subClassOf>
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0014805"/>
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0014896"/>
         <owl:disjointWith>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002162"/>
@@ -57010,114 +57934,19 @@ For example, A and B may be gene products and binding of B by A positively regul
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_4932"/>
             </owl:Restriction>
         </owl:disjointWith>
-        <rdfs:label>cardiac muscle adaptation</rdfs:label>
+        <rdfs:label>smooth muscle hypertrophy</rdfs:label>
     </owl:Class>
     
 
 
-    <!-- http://purl.obolibrary.org/obo/GO_0014888 -->
+    <!-- http://purl.obolibrary.org/obo/GO_0014896 -->
 
-    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0014888">
-        <owl:equivalentClass>
-            <owl:Class>
-                <owl:intersectionOf rdf:parseType="Collection">
-                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/GO_0043500"/>
-                    <owl:Restriction>
-                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000066"/>
-                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0002036"/>
-                    </owl:Restriction>
-                </owl:intersectionOf>
-            </owl:Class>
-        </owl:equivalentClass>
-        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0043500"/>
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0014896">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0003012"/>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000066"/>
-                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0002036"/>
-            </owl:Restriction>
-        </rdfs:subClassOf>
-        <owl:disjointWith>
-            <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002162"/>
-                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_2"/>
-            </owl:Restriction>
-        </owl:disjointWith>
-        <owl:disjointWith>
-            <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002162"/>
-                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_2157"/>
-            </owl:Restriction>
-        </owl:disjointWith>
-        <owl:disjointWith>
-            <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002162"/>
-                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_4896"/>
-            </owl:Restriction>
-        </owl:disjointWith>
-        <owl:disjointWith>
-            <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002162"/>
-                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_4932"/>
-            </owl:Restriction>
-        </owl:disjointWith>
-        <rdfs:label>striated muscle adaptation</rdfs:label>
-    </owl:Class>
-    
-
-
-    <!-- http://purl.obolibrary.org/obo/GO_0014895 -->
-
-    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0014895">
-        <owl:equivalentClass>
-            <owl:Class>
-                <owl:intersectionOf rdf:parseType="Collection">
-                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/GO_0014896"/>
-                    <owl:Restriction>
-                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000066"/>
-                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0001135"/>
-                    </owl:Restriction>
-                </owl:intersectionOf>
-            </owl:Class>
-        </owl:equivalentClass>
-        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0014805"/>
-        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0014896"/>
-        <owl:disjointWith>
-            <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002162"/>
-                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_2"/>
-            </owl:Restriction>
-        </owl:disjointWith>
-        <owl:disjointWith>
-            <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002162"/>
-                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_2157"/>
-            </owl:Restriction>
-        </owl:disjointWith>
-        <owl:disjointWith>
-            <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002162"/>
-                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_4896"/>
-            </owl:Restriction>
-        </owl:disjointWith>
-        <owl:disjointWith>
-            <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002162"/>
-                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_4932"/>
-            </owl:Restriction>
-        </owl:disjointWith>
-        <rdfs:label>smooth muscle hypertrophy</rdfs:label>
-    </owl:Class>
-    
-
-
-    <!-- http://purl.obolibrary.org/obo/GO_0014896 -->
-
-    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0014896">
-        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0003012"/>
-        <rdfs:subClassOf>
-            <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000066"/>
-                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0002385"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0002385"/>
             </owl:Restriction>
         </rdfs:subClassOf>
         <owl:disjointWith>
@@ -57441,6 +58270,44 @@ For example, A and B may be gene products and binding of B by A positively regul
     
 
 
+    <!-- http://purl.obolibrary.org/obo/GO_0015078 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0015078">
+        <owl:equivalentClass>
+            <owl:Class>
+                <owl:intersectionOf rdf:parseType="Collection">
+                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/GO_0005215"/>
+                    <owl:Restriction>
+                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002342"/>
+                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0016020"/>
+                    </owl:Restriction>
+                    <owl:Restriction>
+                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0004009"/>
+                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_15378"/>
+                    </owl:Restriction>
+                </owl:intersectionOf>
+            </owl:Class>
+        </owl:equivalentClass>
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0008324"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_1902600"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0004009"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_15378"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
+        <oboInOwl:hasExactSynonym>hydrogen ion transmembrane transporter activity</oboInOwl:hasExactSynonym>
+        <oboInOwl:hasExactSynonym>proton transporter activity</oboInOwl:hasExactSynonym>
+        <rdfs:label>proton transmembrane transporter activity</rdfs:label>
+    </owl:Class>
+    
+
+
     <!-- http://purl.obolibrary.org/obo/GO_0015081 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0015081">
@@ -67878,6 +68745,7 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0030312"/>
         <owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/GO_0032991"/>
         <owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/GO_0043226"/>
+        <owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/GO_0044423"/>
         <oboInOwl:hasExactSynonym>proteinaceous extracellular matrix</oboInOwl:hasExactSynonym>
         <rdfs:label>extracellular matrix</rdfs:label>
     </owl:Class>
@@ -72537,6 +73405,7 @@ For example, A and B may be gene products and binding of B by A positively regul
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/PR_000000001"/>
             </owl:Restriction>
         </rdfs:subClassOf>
+        <owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/GO_0044423"/>
         <owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/GO_0110165"/>
         <obo:IAO_0000115>A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.</obo:IAO_0000115>
         <obo:IAO_0000118>protein complex</obo:IAO_0000118>
@@ -80788,6 +81657,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0043226">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0110165"/>
+        <owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/GO_0044423"/>
         <rdfs:label>organelle</rdfs:label>
     </owl:Class>
     
@@ -83214,7 +84084,35 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0044423">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0005575"/>
+        <rdfs:subClassOf>
+            <owl:Class>
+                <owl:complementOf>
+                    <owl:Restriction>
+                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002162"/>
+                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_131567"/>
+                    </owl:Restriction>
+                </owl:complementOf>
+            </owl:Class>
+        </rdfs:subClassOf>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002162"/>
+                <owl:someValuesFrom>
+                    <owl:Class>
+                        <owl:complementOf rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_131567"/>
+                    </owl:Class>
+                </owl:someValuesFrom>
+            </owl:Restriction>
+        </rdfs:subClassOf>
+        <owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/GO_0110165"/>
+        <owl:disjointWith>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002162"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_131567"/>
+            </owl:Restriction>
+        </owl:disjointWith>
         <obo:IAO_0000115>Any constituent part of a virion, a complete fully infectious extracellular virus particle.</obo:IAO_0000115>
+        <oboInOwl:hasExactSynonym>virion part</oboInOwl:hasExactSynonym>
         <rdfs:label>virion component</rdfs:label>
     </owl:Class>
     
@@ -97021,15 +97919,6 @@ For example, A and B may be gene products and binding of B by A positively regul
     
 
 
-    <!-- http://purl.obolibrary.org/obo/GO_0050952 -->
-
-    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0050952">
-        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0007600"/>
-        <rdfs:label>sensory perception of electrical stimulus</rdfs:label>
-    </owl:Class>
-    
-
-
     <!-- http://purl.obolibrary.org/obo/GO_0050953 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0050953">
@@ -97050,17 +97939,6 @@ For example, A and B may be gene products and binding of B by A positively regul
     
 
 
-    <!-- http://purl.obolibrary.org/obo/GO_0050956 -->
-
-    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0050956">
-        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0050952"/>
-        <oboInOwl:hasExactSynonym>electroception sense</oboInOwl:hasExactSynonym>
-        <oboInOwl:hasExactSynonym>electroceptive sense</oboInOwl:hasExactSynonym>
-        <rdfs:label>electroception</rdfs:label>
-    </owl:Class>
-    
-
-
     <!-- http://purl.obolibrary.org/obo/GO_0050962 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0050962">
@@ -97094,93 +97972,6 @@ For example, A and B may be gene products and binding of B by A positively regul
     
 
 
-    <!-- http://purl.obolibrary.org/obo/GO_0050963 -->
-
-    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0050963">
-        <owl:equivalentClass>
-            <owl:Class>
-                <owl:intersectionOf rdf:parseType="Collection">
-                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/GO_0050981"/>
-                    <owl:Restriction>
-                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
-                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0007600"/>
-                    </owl:Restriction>
-                </owl:intersectionOf>
-            </owl:Class>
-        </owl:equivalentClass>
-        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0050906"/>
-        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0050981"/>
-        <rdfs:subClassOf>
-            <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
-                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0050952"/>
-            </owl:Restriction>
-        </rdfs:subClassOf>
-        <oboInOwl:hasExactSynonym>sensory detection of electrical stimulus</oboInOwl:hasExactSynonym>
-        <oboInOwl:hasExactSynonym>sensory detection of electrical stimulus during sensory perception</oboInOwl:hasExactSynonym>
-        <oboInOwl:hasExactSynonym>sensory perception, sensory detection of electrical stimulus</oboInOwl:hasExactSynonym>
-        <oboInOwl:hasExactSynonym>sensory perception, sensory transduction of electrical stimulus</oboInOwl:hasExactSynonym>
-        <oboInOwl:hasExactSynonym>sensory transduction of electrical stimulus</oboInOwl:hasExactSynonym>
-        <oboInOwl:hasExactSynonym>sensory transduction of electrical stimulus during sensory perception</oboInOwl:hasExactSynonym>
-        <rdfs:label>detection of electrical stimulus involved in sensory perception</rdfs:label>
-    </owl:Class>
-    
-
-
-    <!-- http://purl.obolibrary.org/obo/GO_0050964 -->
-
-    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0050964">
-        <owl:equivalentClass>
-            <owl:Class>
-                <owl:intersectionOf rdf:parseType="Collection">
-                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/GO_0050981"/>
-                    <owl:Restriction>
-                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
-                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0050956"/>
-                    </owl:Restriction>
-                </owl:intersectionOf>
-            </owl:Class>
-        </owl:equivalentClass>
-        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0050963"/>
-        <rdfs:subClassOf>
-            <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
-                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0050956"/>
-            </owl:Restriction>
-        </rdfs:subClassOf>
-        <oboInOwl:hasExactSynonym>electroception, detection of electrical stimulus</oboInOwl:hasExactSynonym>
-        <oboInOwl:hasExactSynonym>electroception, sensory detection of electrical stimulus</oboInOwl:hasExactSynonym>
-        <oboInOwl:hasExactSynonym>electroception, sensory transduction</oboInOwl:hasExactSynonym>
-        <oboInOwl:hasExactSynonym>electroception, sensory transduction of electrical stimulus</oboInOwl:hasExactSynonym>
-        <rdfs:label>detection of electrical stimulus involved in electroception</rdfs:label>
-    </owl:Class>
-    
-
-
-    <!-- http://purl.obolibrary.org/obo/GO_0050967 -->
-
-    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0050967">
-        <owl:equivalentClass>
-            <owl:Class>
-                <owl:intersectionOf rdf:parseType="Collection">
-                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/GO_0050981"/>
-                    <owl:Restriction>
-                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
-                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0019233"/>
-                    </owl:Restriction>
-                </owl:intersectionOf>
-            </owl:Class>
-        </owl:equivalentClass>
-        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0050963"/>
-        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0062149"/>
-        <oboInOwl:hasExactSynonym>perception of pain, detection of electrical stimulus</oboInOwl:hasExactSynonym>
-        <oboInOwl:hasExactSynonym>perception of pain, sensory detection of electrical stimulus</oboInOwl:hasExactSynonym>
-        <oboInOwl:hasExactSynonym>perception of pain, sensory transduction of electrical stimulus</oboInOwl:hasExactSynonym>
-        <rdfs:label>detection of electrical stimulus involved in sensory perception of pain</rdfs:label>
-    </owl:Class>
-    
-
-
     <!-- http://purl.obolibrary.org/obo/GO_0050968 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0050968">
@@ -97220,16 +98011,6 @@ For example, A and B may be gene products and binding of B by A positively regul
     
 
 
-    <!-- http://purl.obolibrary.org/obo/GO_0050981 -->
-
-    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0050981">
-        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0009582"/>
-        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0051602"/>
-        <rdfs:label>detection of electrical stimulus</rdfs:label>
-    </owl:Class>
-    
-
-
     <!-- http://purl.obolibrary.org/obo/GO_0050994 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0050994">
@@ -99660,15 +100441,6 @@ For example, A and B may be gene products and binding of B by A positively regul
     
 
 
-    <!-- http://purl.obolibrary.org/obo/GO_0051602 -->
-
-    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0051602">
-        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0009628"/>
-        <rdfs:label>response to electrical stimulus</rdfs:label>
-    </owl:Class>
-    
-
-
     <!-- http://purl.obolibrary.org/obo/GO_0051606 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0051606">
@@ -124993,6 +125765,7 @@ For example, A and B may be gene products and binding of B by A positively regul
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/COB_0000013"/>
             </owl:Restriction>
         </rdfs:subClassOf>
+        <owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000001"/>
         <obo:IAO_0000115>A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex.</obo:IAO_0000115>
         <oboInOwl:hasExactSynonym>cellular anatomical entity</oboInOwl:hasExactSynonym>
         <rdfs:label>cellular anatomical entity</rdfs:label>
@@ -125107,6 +125880,40 @@ For example, A and B may be gene products and binding of B by A positively regul
     
 
 
+    <!-- http://purl.obolibrary.org/obo/GO_0120029 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0120029">
+        <owl:equivalentClass>
+            <owl:Class>
+                <owl:intersectionOf rdf:parseType="Collection">
+                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/GO_0006810"/>
+                    <owl:Restriction>
+                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002338"/>
+                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0005829"/>
+                    </owl:Restriction>
+                    <owl:Restriction>
+                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002339"/>
+                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0005576"/>
+                    </owl:Restriction>
+                    <owl:Restriction>
+                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002342"/>
+                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0005886"/>
+                    </owl:Restriction>
+                    <owl:Restriction>
+                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0004009"/>
+                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_15378"/>
+                    </owl:Restriction>
+                </owl:intersectionOf>
+            </owl:Class>
+        </owl:equivalentClass>
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0140115"/>
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_1902600"/>
+        <oboInOwl:hasExactSynonym>hydrogen ion export across plasma membrane</oboInOwl:hasExactSynonym>
+        <rdfs:label>proton export across plasma membrane</rdfs:label>
+    </owl:Class>
+    
+
+
     <!-- http://purl.obolibrary.org/obo/GO_0120031 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0120031">
@@ -133867,6 +134674,35 @@ For example, A and B may be gene products and binding of B by A positively regul
     
 
 
+    <!-- http://purl.obolibrary.org/obo/GO_1902600 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_1902600">
+        <owl:equivalentClass>
+            <owl:Class>
+                <owl:intersectionOf rdf:parseType="Collection">
+                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/GO_0055085"/>
+                    <owl:Restriction>
+                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0004009"/>
+                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_15378"/>
+                    </owl:Restriction>
+                </owl:intersectionOf>
+            </owl:Class>
+        </owl:equivalentClass>
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0098655"/>
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0098662"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0004009"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_15378"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
+        <oboInOwl:hasExactSynonym>hydrogen ion transmembrane transport</oboInOwl:hasExactSynonym>
+        <oboInOwl:hasExactSynonym>hydrogen transmembrane transport</oboInOwl:hasExactSynonym>
+        <rdfs:label>proton transmembrane transport</rdfs:label>
+    </owl:Class>
+    
+
+
     <!-- http://purl.obolibrary.org/obo/GO_1902679 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_1902679">
@@ -152650,6 +153486,7 @@ interpreted by or directly executed by a processing unit.</obo:IAO_0000115>
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/IAO_0000027">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000030"/>
         <obo:IAO_0000115 xml:lang="en">An information content entity that is intended to be a truthful statement about something (modulo, e.g., measurement precision or other systematic errors) and is constructed/acquired by a method which reliably tends to produce (approximately) truthful statements.</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">data entity</rdfs:label>
         <rdfs:label xml:lang="en">data item</rdfs:label>
     </owl:Class>
     
@@ -153192,6 +154029,24 @@ clustering algorithm.</obo:IAO_0000115>
     
 
 
+    <!-- http://purl.obolibrary.org/obo/NCBITaxon_1224 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_1224">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_3379134"/>
+        <rdfs:label>Pseudomonadota</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/NCBITaxon_1236 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_1236">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_1224"/>
+        <rdfs:label>Gammaproteobacteria</rdfs:label>
+    </owl:Class>
+    
+
+
     <!-- http://purl.obolibrary.org/obo/NCBITaxon_124129 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_124129">
@@ -153242,7 +154097,9 @@ clustering algorithm.</obo:IAO_0000115>
     <!-- http://purl.obolibrary.org/obo/NCBITaxon_131567 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_131567">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/COB_0000022"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_1"/>
+        <rdfs:label>cellular organism</rdfs:label>
         <rdfs:label>cellular organisms</rdfs:label>
     </owl:Class>
     
@@ -153577,9 +154434,7 @@ clustering algorithm.</obo:IAO_0000115>
     <!-- http://purl.obolibrary.org/obo/NCBITaxon_2759 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_2759">
-        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/COB_0000022"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_131567"/>
-        <obo:IAO_0000118>eucaryotes</obo:IAO_0000118>
         <obo:IAO_0000118>eukaryotes</obo:IAO_0000118>
         <rdfs:label>Eukaryota</rdfs:label>
     </owl:Class>
@@ -153806,6 +154661,7 @@ clustering algorithm.</obo:IAO_0000115>
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_33208">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_33154"/>
         <owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_4751"/>
+        <obo:IAO_0000118>animals</obo:IAO_0000118>
         <obo:IAO_0000118>metazoans</obo:IAO_0000118>
         <obo:IAO_0000118>multicellular animals</obo:IAO_0000118>
         <rdfs:label>Metazoa</rdfs:label>
@@ -153905,6 +154761,15 @@ clustering algorithm.</obo:IAO_0000115>
     
 
 
+    <!-- http://purl.obolibrary.org/obo/NCBITaxon_3379134 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_3379134">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_2"/>
+        <rdfs:label>Pseudomonadati</rdfs:label>
+    </owl:Class>
+    
+
+
     <!-- http://purl.obolibrary.org/obo/NCBITaxon_3398 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_3398">
@@ -154222,6 +155087,15 @@ clustering algorithm.</obo:IAO_0000115>
     
 
 
+    <!-- http://purl.obolibrary.org/obo/NCBITaxon_543 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_543">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_91347"/>
+        <rdfs:label>Enterobacteriaceae</rdfs:label>
+    </owl:Class>
+    
+
+
     <!-- http://purl.obolibrary.org/obo/NCBITaxon_554915 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_554915">
@@ -154249,6 +155123,24 @@ clustering algorithm.</obo:IAO_0000115>
     
 
 
+    <!-- http://purl.obolibrary.org/obo/NCBITaxon_561 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_561">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_543"/>
+        <rdfs:label>Escherichia</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/NCBITaxon_562 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_562">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_561"/>
+        <rdfs:label>Escherichia coli</rdfs:label>
+    </owl:Class>
+    
+
+
     <!-- http://purl.obolibrary.org/obo/NCBITaxon_5782 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_5782">
@@ -154387,6 +155279,15 @@ clustering algorithm.</obo:IAO_0000115>
     
 
 
+    <!-- http://purl.obolibrary.org/obo/NCBITaxon_637912 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_637912">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_562"/>
+        <rdfs:label>Escherichia coli OP50</rdfs:label>
+    </owl:Class>
+    
+
+
     <!-- http://purl.obolibrary.org/obo/NCBITaxon_6656 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_6656">
@@ -154869,6 +155770,15 @@ clustering algorithm.</obo:IAO_0000115>
     
 
 
+    <!-- http://purl.obolibrary.org/obo/NCBITaxon_91347 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_91347">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_1236"/>
+        <rdfs:label>Enterobacterales</rdfs:label>
+    </owl:Class>
+    
+
+
     <!-- http://purl.obolibrary.org/obo/NCBITaxon_9254 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_9254">
@@ -155045,6 +155955,15 @@ clustering algorithm.</obo:IAO_0000115>
     
 
 
+    <!-- http://purl.obolibrary.org/obo/NCIT_C16203 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCIT_C16203">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCIT_C43431"/>
+        <rdfs:label>Clinical or Research Activity</rdfs:label>
+    </owl:Class>
+    
+
+
     <!-- http://purl.obolibrary.org/obo/NCIT_C16847 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCIT_C16847">
@@ -155054,6 +155973,25 @@ clustering algorithm.</obo:IAO_0000115>
     
 
 
+    <!-- http://purl.obolibrary.org/obo/NCIT_C16853 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCIT_C16853">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCIT_C17369"/>
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCIT_C74957"/>
+        <rdfs:label>Microscopy</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/NCIT_C16856 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCIT_C16856">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCIT_C17995"/>
+        <rdfs:label>Fluorescence Microscopy</rdfs:label>
+    </owl:Class>
+    
+
+
     <!-- http://purl.obolibrary.org/obo/NCIT_C17187 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCIT_C17187">
@@ -155072,6 +156010,15 @@ clustering algorithm.</obo:IAO_0000115>
     
 
 
+    <!-- http://purl.obolibrary.org/obo/NCIT_C17369 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCIT_C17369">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCIT_C25218"/>
+        <rdfs:label>Imaging Procedure</rdfs:label>
+    </owl:Class>
+    
+
+
     <!-- http://purl.obolibrary.org/obo/NCIT_C179817 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCIT_C179817">
@@ -155082,6 +156029,15 @@ clustering algorithm.</obo:IAO_0000115>
     
 
 
+    <!-- http://purl.obolibrary.org/obo/NCIT_C17995 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCIT_C17995">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCIT_C16853"/>
+        <rdfs:label>Light Microscopy</rdfs:label>
+    </owl:Class>
+    
+
+
     <!-- http://purl.obolibrary.org/obo/NCIT_C18141 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCIT_C18141">
@@ -155210,6 +156166,15 @@ clustering algorithm.</obo:IAO_0000115>
     
 
 
+    <!-- http://purl.obolibrary.org/obo/NCIT_C25218 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCIT_C25218">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCIT_C16203"/>
+        <rdfs:label>Clinical Intervention or Procedure</rdfs:label>
+    </owl:Class>
+    
+
+
     <!-- http://purl.obolibrary.org/obo/NCIT_C25284 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCIT_C25284">
@@ -155228,6 +156193,15 @@ clustering algorithm.</obo:IAO_0000115>
     
 
 
+    <!-- http://purl.obolibrary.org/obo/NCIT_C25294 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCIT_C25294">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCIT_C25218"/>
+        <rdfs:label>Laboratory Procedure</rdfs:label>
+    </owl:Class>
+    
+
+
     <!-- http://purl.obolibrary.org/obo/NCIT_C25335 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCIT_C25335">
@@ -155435,6 +156409,15 @@ clustering algorithm.</obo:IAO_0000115>
     
 
 
+    <!-- http://purl.obolibrary.org/obo/NCIT_C74957 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCIT_C74957">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCIT_C25294"/>
+        <rdfs:label>Mixed Category Laboratory Procedure</rdfs:label>
+    </owl:Class>
+    
+
+
     <!-- http://purl.obolibrary.org/obo/NCIT_C85776 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCIT_C85776">
@@ -160575,13 +161558,22 @@ class labels for these objects. The resulting predictor can be used to attach cl
     <!-- http://purl.obolibrary.org/obo/UBERON_0000000 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0000000">
-        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
         <owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/UBERON_0001062"/>
         <rdfs:label>processual entity</rdfs:label>
     </owl:Class>
     
 
 
+    <!-- http://purl.obolibrary.org/obo/UBERON_0000001 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0000001">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000465"/>
+        <owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000468"/>
+        <rdfs:label>gross anatomical part</rdfs:label>
+    </owl:Class>
+    
+
+
     <!-- http://purl.obolibrary.org/obo/UBERON_0000005 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0000005">
@@ -161367,6 +162359,7 @@ class labels for these objects. The resulting predictor can be used to attach cl
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000071"/>
             </owl:Restriction>
         </rdfs:subClassOf>
+        <obo:IAO_0000115>Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism&apos;s own genome.</obo:IAO_0000115>
         <oboInOwl:hasExactSynonym>biological structure</oboInOwl:hasExactSynonym>
         <rdfs:label>anatomical structure</rdfs:label>
     </owl:Class>
@@ -161976,6 +162969,7 @@ class labels for these objects. The resulting predictor can be used to attach cl
     <!-- http://purl.obolibrary.org/obo/UBERON_0000104 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0000104">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000000"/>
         <rdfs:subClassOf>
             <owl:Restriction>
@@ -161995,6 +162989,7 @@ class labels for these objects. The resulting predictor can be used to attach cl
     <!-- http://purl.obolibrary.org/obo/UBERON_0000105 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0000105">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000000"/>
         <rdfs:subClassOf>
             <owl:Restriction>
@@ -162682,12 +163677,6 @@ class labels for these objects. The resulting predictor can be used to attach cl
             </owl:Class>
         </owl:equivalentClass>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/UBERON_0004921"/>
-        <rdfs:subClassOf>
-            <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
-                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0001155"/>
-            </owl:Restriction>
-        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/uberon/core#subdivision_of"/>
@@ -163970,7 +164959,7 @@ class labels for these objects. The resulting predictor can be used to attach cl
     <!-- http://purl.obolibrary.org/obo/UBERON_0000463 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0000463">
-        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000465"/>
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000001"/>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
@@ -163983,6 +164972,7 @@ class labels for these objects. The resulting predictor can be used to attach cl
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/PATO_0002198"/>
             </owl:Restriction>
         </rdfs:subClassOf>
+        <owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000468"/>
         <rdfs:label>organism substance</rdfs:label>
     </owl:Class>
     
@@ -164127,6 +165117,7 @@ class labels for these objects. The resulting predictor can be used to attach cl
     <!-- http://purl.obolibrary.org/obo/UBERON_0000476 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0000476">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000001"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000061"/>
         <rdfs:label>acellular anatomical structure</rdfs:label>
     </owl:Class>
@@ -193316,12 +194307,6 @@ class labels for these objects. The resulting predictor can be used to attach cl
             </owl:Class>
         </owl:equivalentClass>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/UBERON_0013522"/>
-        <rdfs:subClassOf>
-            <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
-                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0001555"/>
-            </owl:Restriction>
-        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/uberon/core#subdivision_of"/>
@@ -195697,7 +196682,7 @@ class labels for these objects. The resulting predictor can be used to attach cl
     <!-- http://purl.obolibrary.org/obo/UBERON_0005423 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0005423">
-        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000465"/>
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000001"/>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002215"/>
@@ -198140,12 +199125,6 @@ class labels for these objects. The resulting predictor can be used to attach cl
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0002090"/>
             </owl:Restriction>
         </rdfs:subClassOf>
-        <rdfs:subClassOf>
-            <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
-                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0006071"/>
-            </owl:Restriction>
-        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/uberon/core#subdivision_of"/>
@@ -198172,12 +199151,6 @@ class labels for these objects. The resulting predictor can be used to attach cl
             </owl:Class>
         </owl:equivalentClass>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000075"/>
-        <rdfs:subClassOf>
-            <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
-                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0001130"/>
-            </owl:Restriction>
-        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
@@ -205617,12 +206590,6 @@ class labels for these objects. The resulting predictor can be used to attach cl
             </owl:Class>
         </owl:equivalentClass>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/UBERON_0006077"/>
-        <rdfs:subClassOf>
-            <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
-                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0002100"/>
-            </owl:Restriction>
-        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/uberon/core#subdivision_of"/>
@@ -209718,34 +210685,6 @@ class labels for these objects. The resulting predictor can be used to attach cl
     
 
 
-    <!-- http://purl.obolibrary.org/obo/UBERON_0010521 -->
-
-    <owl:Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0010521">
-        <owl:equivalentClass>
-            <owl:Class>
-                <owl:intersectionOf rdf:parseType="Collection">
-                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/UBERON_0000062"/>
-                    <owl:Restriction>
-                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002215"/>
-                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0050964"/>
-                    </owl:Restriction>
-                </owl:intersectionOf>
-            </owl:Class>
-        </owl:equivalentClass>
-        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000020"/>
-        <rdfs:subClassOf>
-            <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002215"/>
-                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0050964"/>
-            </owl:Restriction>
-        </rdfs:subClassOf>
-        <oboInOwl:hasExactSynonym>electric sense organ</oboInOwl:hasExactSynonym>
-        <oboInOwl:hasExactSynonym>electroreception organ</oboInOwl:hasExactSynonym>
-        <rdfs:label>electroreceptor organ</rdfs:label>
-    </owl:Class>
-    
-
-
     <!-- http://purl.obolibrary.org/obo/UBERON_0010522 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0010522">
@@ -214074,12 +215013,6 @@ class labels for these objects. The resulting predictor can be used to attach cl
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0013522">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000064"/>
-        <rdfs:subClassOf>
-            <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
-                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000025"/>
-            </owl:Restriction>
-        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
@@ -220902,7 +221835,7 @@ class labels for these objects. The resulting predictor can be used to attach cl
     <!-- http://purl.obolibrary.org/obo/UBERON_0036215 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0036215">
-        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000465"/>
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000001"/>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002007"/>
@@ -223410,6 +224343,32 @@ class labels for these objects. The resulting predictor can be used to attach cl
     
 
 
+    <!-- http://purl.obolibrary.org/obo/UBERON_8850001 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/UBERON_8850001">
+        <owl:equivalentClass>
+            <owl:Class>
+                <owl:intersectionOf rdf:parseType="Collection">
+                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/UBERON_0000483"/>
+                    <owl:Restriction>
+                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
+                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_8410050"/>
+                    </owl:Restriction>
+                </owl:intersectionOf>
+            </owl:Class>
+        </owl:equivalentClass>
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/UBERON_0001278"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_8410050"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
+        <rdfs:label>epithelium of anorectum</rdfs:label>
+    </owl:Class>
+    
+
+
     <!-- http://purl.obolibrary.org/obo/UO_0000001 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/UO_0000001">
@@ -223500,6 +224459,18 @@ class labels for these objects. The resulting predictor can be used to attach cl
     
 
 
+    <!-- http://purl.obolibrary.org/obo/format_1929 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/format_1929"/>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/NCBITaxon:637912 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon:637912"/>
+    
+
+
     <!-- http://www.geneontology.org/formats/oboInOwl#ObsoleteClass -->
 
     <owl:Class rdf:about="http://www.geneontology.org/formats/oboInOwl#ObsoleteClass">
diff --git a/empty-simple.json b/empty-simple.json
index 35c78fd..415c047 100644
--- a/empty-simple.json
+++ b/empty-simple.json
@@ -16,12 +16,12 @@
         "val" : "EMPTY by NDI is licensed under CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/). You are free to share (copy and redistribute the material in any medium or format) and adapt (remix, transform, and build upon the material) for any purpose, even commercially. You must give appropriate credit (by using the original ontology IRI for the whole ontology or original term IRIs for individual terms), provide a link to the license, and indicate if any changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use."
       }, {
         "pred" : "http://www.w3.org/2002/07/owl#versionInfo",
-        "val" : "2026-02-23"
+        "val" : "2026-04-04"
       }, {
         "pred" : "http://www.w3.org/2002/07/owl#versionInfo",
         "val" : "Release 2025-07-10"
       } ],
-      "version" : "http://purl.obolibrary.org/obo/empty/releases/2026-02-23/empty-simple.json"
+      "version" : "http://purl.obolibrary.org/obo/empty/releases/2026-04-04/empty-simple.json"
     },
     "nodes" : [ {
       "id" : "http://purl.obolibrary.org/obo/EMPTY_0000001",
@@ -74,7 +74,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's body (typically defined by its center point or a significant portion) fully enters the user-defined zone designated as 'Open Arm (North)'. The 'Open Arm (North)' is one of the two open arms, distinguished by its assigned 'north' orientation or designation in the experimental setup. Unit of measure: count"
+          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's body (typically defined by its center point or a significant portion) fully enters the user-defined zone designated as 'Open Arm (North)'. The 'Open Arm (North)' is one of the two open arms, distinguished by its assigned 'north' orientation or designation in the experimental setup. Unit: count"
         }
       }
     }, {
@@ -83,7 +83,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's body (typically defined by its center point or a significant portion) fully enters the user-defined zone designated as 'Open Arm (South)'. The 'Open Arm (South)' is one of the two open arms, distinguished by its assigned 'south' orientation or designation in the experimental setup. Unit of measure: count"
+          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's body (typically defined by its center point or a significant portion) fully enters the user-defined zone designated as 'Open Arm (South)'. The 'Open Arm (South)' is one of the two open arms, distinguished by its assigned 'south' orientation or designation in the experimental setup. Unit: count"
         }
       }
     }, {
@@ -92,7 +92,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this represents the total number of times the animal's body (typically defined by its center point or a significant portion) fully enters the designated open arm zones (e.g., 'Open Arm (North)' and 'Open Arm (South)'). It is a common measure of exploration and anxiety. Unit of measure: count"
+          "val" : "In the Elevated Plus Maze task, this represents the total number of times the animal's body (typically defined by its center point or a significant portion) fully enters the designated open arm zones (e.g., 'Open Arm (North)' and 'Open Arm (South)'). It is a common measure of exploration and anxiety. Unit: count"
         }
       }
     }, {
@@ -101,7 +101,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's head (specifically tracked by the software) enters the user-defined 'Open Arm (North)' zone, irrespective of full body entry. This can indicate risk assessment or tentative exploration of the arm designated as 'north'. Unit of measure: count"
+          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's head (specifically tracked by the software) enters the user-defined 'Open Arm (North)' zone, irrespective of full body entry. This can indicate risk assessment or tentative exploration of the arm designated as 'north'. Unit: count"
         }
       }
     }, {
@@ -110,7 +110,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's head (specifically tracked by the software) enters the user-defined 'Open Arm (South)' zone, irrespective of full body entry, often reflecting cautious exploration of the open arm designated as 'south'. Unit of measure: count"
+          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's head (specifically tracked by the software) enters the user-defined 'Open Arm (South)' zone, irrespective of full body entry, often reflecting cautious exploration of the open arm designated as 'south'. Unit: count"
         }
       }
     }, {
@@ -119,7 +119,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this is the total number of times the animal's head (specifically tracked by the software) enters any of the designated open arm zones (e.g., 'Open Arm (North)' and 'Open Arm (South)'), considered an indicator of risk-assessment behavior. Unit of measure: count"
+          "val" : "In the Elevated Plus Maze task, this is the total number of times the animal's head (specifically tracked by the software) enters any of the designated open arm zones (e.g., 'Open Arm (North)' and 'Open Arm (South)'), considered an indicator of risk-assessment behavior. Unit: count"
         }
       }
     }, {
@@ -128,7 +128,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Open Arm (North)' zone. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Open Arm (North)' zone. Unit: seconds"
         }
       }
     }, {
@@ -137,7 +137,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Open Arm (South)' zone. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Open Arm (South)' zone. Unit: seconds"
         }
       }
     }, {
@@ -146,7 +146,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this is the cumulative total duration the animal's body spends within any of the designated open arm zones (e.g., 'Open Arm (North)' and 'Open Arm (South)'). Less time is generally indicative of higher anxiety. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this is the cumulative total duration the animal's body spends within any of the designated open arm zones (e.g., 'Open Arm (North)' and 'Open Arm (South)'). Less time is generally indicative of higher anxiety. Unit: seconds"
         }
       }
     }, {
@@ -155,7 +155,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this represents the percentage of the total test duration that the animal spends in any of the designated open arm zones (e.g., 'Open Arm (North)' and 'Open Arm (South)'). Unit of measure: %"
+          "val" : "In the Elevated Plus Maze task, this represents the percentage of the total test duration that the animal spends in any of the designated open arm zones (e.g., 'Open Arm (North)' and 'Open Arm (South)'). Unit: %"
         }
       }
     }, {
@@ -164,7 +164,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Open Arm (North)' zone. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Open Arm (North)' zone. Unit: seconds"
         }
       }
     }, {
@@ -173,7 +173,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Open Arm (South)' zone. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Open Arm (South)' zone. Unit: seconds"
         }
       }
     }, {
@@ -182,7 +182,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into any of the designated open arm zones (e.g., 'Open Arm (North)' or 'Open Arm (South)'). Longer latencies often suggest higher anxiety. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into any of the designated open arm zones (e.g., 'Open Arm (North)' or 'Open Arm (South)'). Longer latencies often suggest higher anxiety. Unit: seconds"
         }
       }
     }, {
@@ -191,7 +191,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Open Arm (North)' zone, as detected by the tracking software. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Open Arm (North)' zone, as detected by the tracking software. Unit: seconds"
         }
       }
     }, {
@@ -200,7 +200,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Open Arm (South)' zone, as detected by the tracking software. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Open Arm (South)' zone, as detected by the tracking software. Unit: seconds"
         }
       }
     }, {
@@ -209,7 +209,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this is the cumulative duration the animal spends actively moving towards any of the designated open arm zones (e.g., 'Open Arm (North)' or 'Open Arm (South)'), reflecting approach motivation. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this is the cumulative duration the animal spends actively moving towards any of the designated open arm zones (e.g., 'Open Arm (North)' or 'Open Arm (South)'), reflecting approach motivation. Unit: seconds"
         }
       }
     }, {
@@ -218,7 +218,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior (a state of immobility except for respiratory movements) while within the user-defined 'Open Arm (North)' zone. Freezing is a common fear response. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior (a state of immobility except for respiratory movements) while within the user-defined 'Open Arm (North)' zone. Freezing is a common fear response. Unit: seconds"
         }
       }
     }, {
@@ -227,7 +227,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined 'Open Arm (South)' zone. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined 'Open Arm (South)' zone. Unit: seconds"
         }
       }
     }, {
@@ -236,7 +236,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this is the cumulative duration the animal exhibits freezing behavior while within any of the designated open arm zones (e.g., 'Open Arm (North)' or 'Open Arm (South)'), indicating fear or anxiety. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this is the cumulative duration the animal exhibits freezing behavior while within any of the designated open arm zones (e.g., 'Open Arm (North)' or 'Open Arm (South)'), indicating fear or anxiety. Unit: seconds"
         }
       }
     }, {
@@ -245,7 +245,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's body fully enters the user-defined 'Closed Arm (West)' zone, representing the enclosed arm designated as 'west'. Unit of measure: count"
+          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's body fully enters the user-defined 'Closed Arm (West)' zone, representing the enclosed arm designated as 'west'. Unit: count"
         }
       }
     }, {
@@ -254,7 +254,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's body fully enters the user-defined 'Closed Arm (East)' zone, representing the enclosed arm designated as 'east'. Unit of measure: count"
+          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's body fully enters the user-defined 'Closed Arm (East)' zone, representing the enclosed arm designated as 'east'. Unit: count"
         }
       }
     }, {
@@ -263,7 +263,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this is the total number of times the animal's body fully enters any of the designated closed arm zones (e.g., 'Closed Arm (West)' and 'Closed Arm (East)'). It is often used as an indicator of general locomotor activity. Unit of measure: count"
+          "val" : "In the Elevated Plus Maze task, this is the total number of times the animal's body fully enters any of the designated closed arm zones (e.g., 'Closed Arm (West)' and 'Closed Arm (East)'). It is often used as an indicator of general locomotor activity. Unit: count"
         }
       }
     }, {
@@ -272,7 +272,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's head enters the user-defined 'Closed Arm (West)' zone. Unit of measure: count"
+          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's head enters the user-defined 'Closed Arm (West)' zone. Unit: count"
         }
       }
     }, {
@@ -281,7 +281,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's head enters the user-defined 'Closed Arm (East)' zone. Unit of measure: count"
+          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's head enters the user-defined 'Closed Arm (East)' zone. Unit: count"
         }
       }
     }, {
@@ -290,7 +290,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this is the total number of times the animal's head enters any of the designated closed arm zones (e.g., 'Closed Arm (West)' and 'Closed Arm (East)'). Unit of measure: count"
+          "val" : "In the Elevated Plus Maze task, this is the total number of times the animal's head enters any of the designated closed arm zones (e.g., 'Closed Arm (West)' and 'Closed Arm (East)'). Unit: count"
         }
       }
     }, {
@@ -299,7 +299,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Closed Arm (West)' zone. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Closed Arm (West)' zone. Unit: seconds"
         }
       }
     }, {
@@ -308,7 +308,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Closed Arm (East)' zone. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Closed Arm (East)' zone. Unit: seconds"
         }
       }
     }, {
@@ -317,7 +317,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this is the cumulative total duration the animal's body spends within any of the designated closed arm zones (e.g., 'Closed Arm (West)' and 'Closed Arm (East)'). Animals typically spend more time in these 'safer' areas. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this is the cumulative total duration the animal's body spends within any of the designated closed arm zones (e.g., 'Closed Arm (West)' and 'Closed Arm (East)'). Animals typically spend more time in these 'safer' areas. Unit: seconds"
         }
       }
     }, {
@@ -326,7 +326,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this represents the percentage of the total test duration that the animal spends in any of the designated closed arm zones (e.g., 'Closed Arm (West)' and 'Closed Arm (East)'). Unit of measure: %"
+          "val" : "In the Elevated Plus Maze task, this represents the percentage of the total test duration that the animal spends in any of the designated closed arm zones (e.g., 'Closed Arm (West)' and 'Closed Arm (East)'). Unit: %"
         }
       }
     }, {
@@ -335,7 +335,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Closed Arm (West)' zone. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Closed Arm (West)' zone. Unit: seconds"
         }
       }
     }, {
@@ -344,7 +344,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Closed Arm (East)' zone. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Closed Arm (East)' zone. Unit: seconds"
         }
       }
     }, {
@@ -353,7 +353,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into any of the designated closed arm zones (e.g., 'Closed Arm (West)' or 'Closed Arm (East)'). Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into any of the designated closed arm zones (e.g., 'Closed Arm (West)' or 'Closed Arm (East)'). Unit: seconds"
         }
       }
     }, {
@@ -362,7 +362,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Closed Arm (West)' zone. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Closed Arm (West)' zone. Unit: seconds"
         }
       }
     }, {
@@ -371,7 +371,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Closed Arm (East)' zone. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Closed Arm (East)' zone. Unit: seconds"
         }
       }
     }, {
@@ -380,7 +380,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this is the cumulative duration the animal spends actively moving towards any of the designated closed arm zones (e.g., 'Closed Arm (West)' or 'Closed Arm (East)'). Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this is the cumulative duration the animal spends actively moving towards any of the designated closed arm zones (e.g., 'Closed Arm (West)' or 'Closed Arm (East)'). Unit: seconds"
         }
       }
     }, {
@@ -389,7 +389,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined 'Closed Arm (West)' zone. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined 'Closed Arm (West)' zone. Unit: seconds"
         }
       }
     }, {
@@ -398,7 +398,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined 'Closed Arm (East)' zone. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined 'Closed Arm (East)' zone. Unit: seconds"
         }
       }
     }, {
@@ -407,7 +407,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this is the cumulative duration the animal exhibits freezing behavior while within any of the designated closed arm zones (e.g., 'Closed Arm (West)' or 'Closed Arm (East)'). Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this is the cumulative duration the animal exhibits freezing behavior while within any of the designated closed arm zones (e.g., 'Closed Arm (West)' or 'Closed Arm (East)'). Unit: seconds"
         }
       }
     }, {
@@ -416,7 +416,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's body fully enters the user-defined 'Center' zone of the maze, typically from one of the arms. The center zone is the area where all four arms meet. Unit of measure: count"
+          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's body fully enters the user-defined 'Center' zone of the maze, typically from one of the arms. The center zone is the area where all four arms meet. Unit: count"
         }
       }
     }, {
@@ -425,7 +425,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's head enters the user-defined 'Center' zone of the maze. Unit of measure: count"
+          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's head enters the user-defined 'Center' zone of the maze. Unit: count"
         }
       }
     }, {
@@ -434,7 +434,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Center' zone. Time in the center can indicate decision-making or risk assessment. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Center' zone. Time in the center can indicate decision-making or risk assessment. Unit: seconds"
         }
       }
     }, {
@@ -443,7 +443,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this represents the percentage of the total test duration that the animal spends in the user-defined 'Center' zone of the maze. Unit of measure: %"
+          "val" : "In the Elevated Plus Maze task, this represents the percentage of the total test duration that the animal spends in the user-defined 'Center' zone of the maze. Unit: %"
         }
       }
     }, {
@@ -452,7 +452,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Center' zone. If the animal starts in the center, this value may be zero or not applicable. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Center' zone. If the animal starts in the center, this value may be zero or not applicable. Unit: seconds"
         }
       }
     }, {
@@ -461,7 +461,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Center' zone of the maze (e.g., from an arm). Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Center' zone of the maze (e.g., from an arm). Unit: seconds"
         }
       }
     }, {
@@ -470,7 +470,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined 'Center' zone of the maze. Freezing in this relatively exposed area can indicate high anxiety. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined 'Center' zone of the maze. Freezing in this relatively exposed area can indicate high anxiety. Unit: seconds"
         }
       }
     }, {
@@ -497,7 +497,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Fear-potentiated startle paradigm, this is the amplitude of the acoustic startle response (ASR) measured in response to a startle-eliciting stimulus (e.g., 95-dB white noise burst) prior to any fear conditioning procedures, typically assessed during habituation or pre-conditioning phase. This measurement serves as a reference point for later comparisons with post-conditioning startle responses. Unit of measure: arbitrary units or standardized score."
+          "val" : "In the Fear-potentiated startle paradigm, this is the amplitude of the acoustic startle response (ASR) measured in response to a startle-eliciting stimulus (e.g., 95-dB white noise burst) prior to any fear conditioning procedures, typically assessed during habituation or pre-conditioning phase. This measurement serves as a reference point for later comparisons with post-conditioning startle responses. Unit: arbitrary units or standardized score."
         }
       }
     }, {
@@ -542,7 +542,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "Identifier for the specific Plexiglas enclosure or sound-attenuating chamber within the Fear-Potentiated Startle (FPS) apparatus (e.g., San Diego Instruments SR-Lab) in which a subject was tested for a given trial. Unit of measure: count or identifier string"
+          "val" : "Identifier for the specific Plexiglas enclosure or sound-attenuating chamber within the Fear-Potentiated Startle (FPS) apparatus (e.g., San Diego Instruments SR-Lab) in which a subject was tested for a given trial. Unit: count or identifier string"
         }
       }
     }, {
@@ -560,7 +560,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "The total number of data points (samples) recorded and analyzed for a single acoustic startle response, typically within a defined time window following stimulus onset (e.g., a 200-ms window as mentioned in the manuscript). Unit of measure: count"
+          "val" : "The total number of data points (samples) recorded and analyzed for a single acoustic startle response, typically within a defined time window following stimulus onset (e.g., a 200-ms window as mentioned in the manuscript). Unit: count"
         }
       }
     }, {
@@ -569,7 +569,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "The rate at which the analog startle response signal was digitized during data acquisition. Unit of measure: Hertz (Hz)"
+          "val" : "The rate at which the analog startle response signal was digitized during data acquisition. Unit: Hertz (Hz)"
         }
       }
     }, {
@@ -578,7 +578,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "The amplitude of the digitized acoustic startle response signal at the very beginning (onset) of the defined analysis window (e.g., a 200-ms window) used to quantify the reflex. Unit of measure: millivolts (mV) or arbitrary units based on transducer calibration."
+          "val" : "The amplitude of the digitized acoustic startle response signal at the very beginning (onset) of the defined analysis window (e.g., a 200-ms window) used to quantify the reflex. Unit: millivolts (mV) or arbitrary units based on transducer calibration."
         }
       }
     }, {
@@ -587,7 +587,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "The peak amplitude of the acoustic startle response (e.g., 'jump amplitude') detected within the defined analysis window (e.g., 200-ms window) for a given trial. Unit of measure: millivolts (mV) or arbitrary units."
+          "val" : "The peak amplitude of the acoustic startle response (e.g., 'jump amplitude') detected within the defined analysis window (e.g., 200-ms window) for a given trial. Unit: millivolts (mV) or arbitrary units."
         }
       }
     }, {
@@ -596,7 +596,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "The latency from the onset of the startle-eliciting stimulus (or the beginning of the analysis window) to the occurrence of the maximum (peak) amplitude of the acoustic startle response. Unit of measure: milliseconds (ms)"
+          "val" : "The latency from the onset of the startle-eliciting stimulus (or the beginning of the analysis window) to the occurrence of the maximum (peak) amplitude of the acoustic startle response. Unit: milliseconds (ms)"
         }
       }
     }, {
@@ -605,7 +605,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "The average amplitude of the digitized acoustic startle response signal calculated across the entire duration of the defined analysis window (e.g., 200-ms window). Unit of measure: millivolts (mV) or arbitrary units."
+          "val" : "The average amplitude of the digitized acoustic startle response signal calculated across the entire duration of the defined analysis window (e.g., 200-ms window). Unit: millivolts (mV) or arbitrary units."
         }
       }
     }, {
@@ -632,7 +632,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this is the time of the total test duration in seconds'). Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this is the time of the total test duration in seconds'). Unit: seconds"
         }
       }
     }, {
@@ -1609,7 +1609,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "The number of seconds the individual spent freezing during a given period of time. Unit of measure: seconds"
+          "val" : "The number of seconds the individual spent freezing during a given period of time. Unit: seconds"
         }
       }
     }, {
@@ -1618,7 +1618,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the contextual fear conditioning paradigm, this is the time of the block duration in seconds. Unit of measure: seconds"
+          "val" : "In the contextual fear conditioning paradigm, this is the time of the block duration in seconds. Unit: seconds"
         }
       }
     }, {
@@ -2096,6 +2096,262 @@
           "val" : "A digital file for which the format, encoding, or origin cannot be definitively identified by the system or investigator, necessitating further manual review or specialized software for interpretation."
         }
       }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000231",
+      "lbl" : "C. elegans chemotaxis assay parameter",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "A parameter that specifies the technical settings, environmental conditions, or experimental design of a chemotaxis assay involving Caenorhabditis elegans."
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000232",
+      "lbl" : "C. elegans chemotaxis assay parameter: chemoattractant mixture table",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "A table containing the quantities and identities of all chemicals used as a chemoattractant (e.g., isoamyl alcohol, diacetyl) to elicit a directed movement response in C. elegans."
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000233",
+      "lbl" : "C. elegans chemotaxis assay parameter: chemoattractant mixture volume",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "The volume of the chemoattractant mixture pipetted onto the agar plate in a chemotaxis assay. Unit: microliters (μL)."
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000234",
+      "lbl" : "C. elegans chemotaxis assay parameter: assay duration",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "The total time elapsed from the point at which C. elegans are placed on the assay plate until the movement is arrested or the final positions are recorded. Unit: minutes."
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000235",
+      "lbl" : "C. elegans chemotaxis assay measurement",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "A quantitative or qualitative value derived from a C. elegans chemotaxis assay, typically describing the efficiency or directionality of the animals' movement toward or away from a chemical source."
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000236",
+      "lbl" : "C. elegans chemotaxis assay measurement: McCutcheon index",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "A behavioral measurement of chemotactic efficiency defined as the ratio of the straight-line displacement toward the attractant to the total path length traveled by the organism. Values range from -1 to 1."
+        },
+        "synonyms" : [ {
+          "pred" : "hasExactSynonym",
+          "val" : "chemotactic ratio"
+        } ]
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000237",
+      "lbl" : "C. elegans chemotaxis assay measurement: mean velocity",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "The average speed of a C. elegans individual or population during the duration of the chemotaxis assay. Unit: micrometers per second (µm/s)."
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000238",
+      "lbl" : "investigator-defined strain",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "A specific genetic variant or line of an organism designated by the investigator, often containing unique mutations, transgenes, or genomic edits not yet categorized in a public repository."
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000239",
+      "lbl" : "C. elegans strain",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "A specific strain of Caenorhabditis elegans, identified by its genotype or a standard nomenclature (e.g., N2, CB4856), used in experimental procedures."
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000240",
+      "lbl" : "BAB9001",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "A C. elegans strain with the genotype daf-22 (m130). This strain was originally obtained from the Caenorhabditis Genetics Center (CGC) as strain DR476 and subsequently outcrossed three times. [Source: https://doi.org/TBD]"
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000241",
+      "lbl" : "BAB9002",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "A C. elegans klp-6 rescue strain with the genotype klp-6 (my8); Pklp-6::GFP::KLP-6 (array, IndEx 9002). [Source: https://doi.org/TBD]"
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000242",
+      "lbl" : "TM5848",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "A C. elegans strain with the genotype cil-7 (tm5848) I, exhibiting a him phenotype. This strain was obtained from the National BioResource Project (NBRP), Japan. [Source: https://doi.org/TBD]"
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000243",
+      "lbl" : "PT3602",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "A C. elegans strain with the genotype cil-7 (my61[cil-7::mNG])I; him-5(e1490) V. This strain was provided as a gift from the Maureen Barr lab. [Source: https://doi.org/TBD]"
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000244",
+      "lbl" : "BAB9003",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "A C. elegans strain with the genotype PT3602; Pnlp-43_hCaspase nZ (array IndEx 9003). [Source: https://doi.org/TBD]"
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000245",
+      "lbl" : "BAB9004",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "A C. elegans strain with the genotype PT3602; Pklp-6_hCaspase Cz (array IndEx 9004). [Source: https://doi.org/TBD]"
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000246",
+      "lbl" : "BAB9005",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "A C. elegans strain with the genotype PT3602; Pnlp-43_hCaspase nZ (array IndEx 9003) and Pklp-6_hCaspase Cz (array IndEx 9004). [Source: https://doi.org/TBD]"
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000247",
+      "lbl" : "fluorescence imaging measurement",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "fluorescence imaging measurement"
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000248",
+      "lbl" : "mean fluorescence intensity",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "Mean fluorescence intensity. Unit: arbitrary units (AU)"
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000249",
+      "lbl" : "fluorescent punctal count",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "A quantitative measurement of the number of distinct fluorescent spots or puncta detected within a defined region of interest in a fluorescence image. Unit: count"
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000250",
+      "lbl" : "fluorescence imaging parameter",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "A specific parameter related to fluorescence imaging acquisition or assay."
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000251",
+      "lbl" : "fluorescence target ontology identifier",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "fluorescence target ontology identifier"
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000252",
+      "lbl" : "fluorescence target name",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "fluorescence target name"
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000253",
+      "lbl" : "SnapGene file format",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "A .dna file format designed for storing annotated DNA sequences, including linear/circular topology, features, primers, and enzyme sites."
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000254",
+      "lbl" : "Escherichia coli OP50: heat-killed",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "A preparation of Escherichia coli strain OP50 that has been rendered non-viable through the application of heat, typically used as a non-proliferating food source in C. elegans assays."
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000255",
+      "lbl" : "C. elegans transfer method: M9 buffer wash",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "Method used to transfer C. elegans whereby an M9 buffer is used to wash C. elegans off of an agar plate. Animals can then be transferred using a piper."
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000256",
+      "lbl" : "C. elegans transfer method: titanium pick",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "Method used to transfer C. elegans whereby a titanium pick is used to scoop animals off of an agar plate."
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000257",
+      "lbl" : "C. elegans chemotaxis assay: video recording",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "A video recording capturing the behavior of C. elegans during a chemotaxis assay."
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000258",
+      "lbl" : "fluorescence imaging data",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "An image or video acquired using fluorescence microscopy."
+        }
+      }
     }, {
       "id" : "http://purl.obolibrary.org/obo/IAO_0000115",
       "lbl" : "textual definition",
@@ -2103,7 +2359,7 @@
       "propertyType" : "ANNOTATION",
       "meta" : {
         "definition" : {
-          "val" : "The official definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions."
+          "val" : "The official definition."
         }
       }
     }, {
@@ -3298,6 +3554,106 @@
       "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000225",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000083"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000231",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000101"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000232",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000231"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000233",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000231"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000234",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000231"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000235",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000100"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000236",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000235"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000237",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000235"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000238",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000076"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000239",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000238"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000240",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000239"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000241",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000239"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000242",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000239"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000243",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000239"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000244",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000239"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000245",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000239"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000246",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000239"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000247",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000001"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000248",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000247"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000249",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000247"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000250",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000080"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000251",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000250"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000252",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000250"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000255",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000189"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000256",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000189"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000257",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000129"
     } ]
   } ]
 }
\ No newline at end of file
diff --git a/empty-simple.obo b/empty-simple.obo
index 4cf4a20..48d4b90 100644
--- a/empty-simple.obo
+++ b/empty-simple.obo
@@ -1,10 +1,10 @@
 format-version: 1.2
-data-version: empty/releases/2026-02-23/empty-simple.owl
+data-version: empty/releases/2026-04-04/empty-simple.owl
 idspace: oboInOwl http://www.geneontology.org/formats/oboInOwl# 
 idspace: terms http://purl.org/dc/terms/ 
 remark: EMPTY by NDI is licensed under CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/). You are free to share (copy and redistribute the material in any medium or format) and adapt (remix, transform, and build upon the material) for any purpose, even commercially. You must give appropriate credit (by using the original ontology IRI for the whole ontology or original term IRIs for individual terms), provide a link to the license, and indicate if any changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
 ontology: empty/empty-simple
-property_value: owl:versionInfo "2026-02-23" xsd:string
+property_value: owl:versionInfo "2026-04-04" xsd:string
 property_value: owl:versionInfo "Release 2025-07-10" xsd:string
 property_value: terms:description "An ontology of experimental measurements in the sciences, the purposes for which experimental measurements were made, and experimental treatments, with a focus on life sciences." xsd:string
 property_value: terms:license https://creativecommons.org/licenses/by/4.0/
@@ -42,298 +42,298 @@ is_a: EMPTY:0000002 ! behavioral measurement
 [Term]
 id: EMPTY:0000006
 name: elevated plus maze: open arm (north) - entries
-def: "In the Elevated Plus Maze task, this counts the number of times the animal's body (typically defined by its center point or a significant portion) fully enters the user-defined zone designated as 'Open Arm (North)'. The 'Open Arm (North)' is one of the two open arms, distinguished by its assigned 'north' orientation or designation in the experimental setup. Unit of measure: count" []
+def: "In the Elevated Plus Maze task, this counts the number of times the animal's body (typically defined by its center point or a significant portion) fully enters the user-defined zone designated as 'Open Arm (North)'. The 'Open Arm (North)' is one of the two open arms, distinguished by its assigned 'north' orientation or designation in the experimental setup. Unit: count" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 
 [Term]
 id: EMPTY:0000007
 name: elevated plus maze: open arm (south) - entries
-def: "In the Elevated Plus Maze task, this counts the number of times the animal's body (typically defined by its center point or a significant portion) fully enters the user-defined zone designated as 'Open Arm (South)'. The 'Open Arm (South)' is one of the two open arms, distinguished by its assigned 'south' orientation or designation in the experimental setup. Unit of measure: count" []
+def: "In the Elevated Plus Maze task, this counts the number of times the animal's body (typically defined by its center point or a significant portion) fully enters the user-defined zone designated as 'Open Arm (South)'. The 'Open Arm (South)' is one of the two open arms, distinguished by its assigned 'south' orientation or designation in the experimental setup. Unit: count" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 
 [Term]
 id: EMPTY:0000008
 name: elevated plus maze: open arm total entries
-def: "In the Elevated Plus Maze task, this represents the total number of times the animal's body (typically defined by its center point or a significant portion) fully enters the designated open arm zones (e.g., 'Open Arm (North)' and 'Open Arm (South)'). It is a common measure of exploration and anxiety. Unit of measure: count" []
+def: "In the Elevated Plus Maze task, this represents the total number of times the animal's body (typically defined by its center point or a significant portion) fully enters the designated open arm zones (e.g., 'Open Arm (North)' and 'Open Arm (South)'). It is a common measure of exploration and anxiety. Unit: count" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 
 [Term]
 id: EMPTY:0000009
 name: elevated plus maze: open arm (north) - head entries
-def: "In the Elevated Plus Maze task, this counts the number of times the animal's head (specifically tracked by the software) enters the user-defined 'Open Arm (North)' zone, irrespective of full body entry. This can indicate risk assessment or tentative exploration of the arm designated as 'north'. Unit of measure: count" []
+def: "In the Elevated Plus Maze task, this counts the number of times the animal's head (specifically tracked by the software) enters the user-defined 'Open Arm (North)' zone, irrespective of full body entry. This can indicate risk assessment or tentative exploration of the arm designated as 'north'. Unit: count" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 
 [Term]
 id: EMPTY:0000010
 name: elevated plus maze: open arm (south) - head entries
-def: "In the Elevated Plus Maze task, this counts the number of times the animal's head (specifically tracked by the software) enters the user-defined 'Open Arm (South)' zone, irrespective of full body entry, often reflecting cautious exploration of the open arm designated as 'south'. Unit of measure: count" []
+def: "In the Elevated Plus Maze task, this counts the number of times the animal's head (specifically tracked by the software) enters the user-defined 'Open Arm (South)' zone, irrespective of full body entry, often reflecting cautious exploration of the open arm designated as 'south'. Unit: count" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 
 [Term]
 id: EMPTY:0000011
 name: elevated plus maze: open arm total head entries
-def: "In the Elevated Plus Maze task, this is the total number of times the animal's head (specifically tracked by the software) enters any of the designated open arm zones (e.g., 'Open Arm (North)' and 'Open Arm (South)'), considered an indicator of risk-assessment behavior. Unit of measure: count" []
+def: "In the Elevated Plus Maze task, this is the total number of times the animal's head (specifically tracked by the software) enters any of the designated open arm zones (e.g., 'Open Arm (North)' and 'Open Arm (South)'), considered an indicator of risk-assessment behavior. Unit: count" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 
 [Term]
 id: EMPTY:0000012
 name: elevated plus maze: open arm (north) - time
-def: "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Open Arm (North)' zone. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Open Arm (North)' zone. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000013
 name: elevated plus maze: open arm (south) - time
-def: "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Open Arm (South)' zone. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Open Arm (South)' zone. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000014
 name: elevated plus maze: open arm total time
-def: "In the Elevated Plus Maze task, this is the cumulative total duration the animal's body spends within any of the designated open arm zones (e.g., 'Open Arm (North)' and 'Open Arm (South)'). Less time is generally indicative of higher anxiety. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this is the cumulative total duration the animal's body spends within any of the designated open arm zones (e.g., 'Open Arm (North)' and 'Open Arm (South)'). Less time is generally indicative of higher anxiety. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000015
 name: elevated plus maze: open arm total - percent time during test duration
-def: "In the Elevated Plus Maze task, this represents the percentage of the total test duration that the animal spends in any of the designated open arm zones (e.g., 'Open Arm (North)' and 'Open Arm (South)'). Unit of measure: %" []
+def: "In the Elevated Plus Maze task, this represents the percentage of the total test duration that the animal spends in any of the designated open arm zones (e.g., 'Open Arm (North)' and 'Open Arm (South)'). Unit: %" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 
 [Term]
 id: EMPTY:0000016
 name: elevated plus maze: open arm (north) - latency to first entry
-def: "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Open Arm (North)' zone. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Open Arm (North)' zone. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000091 ! timepoint
 
 [Term]
 id: EMPTY:0000017
 name: elevated plus maze: open arm (south) - latency to first entry
-def: "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Open Arm (South)' zone. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Open Arm (South)' zone. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000091 ! timepoint
 
 [Term]
 id: EMPTY:0000018
 name: elevated plus maze: open arm total latency to first entry
-def: "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into any of the designated open arm zones (e.g., 'Open Arm (North)' or 'Open Arm (South)'). Longer latencies often suggest higher anxiety. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into any of the designated open arm zones (e.g., 'Open Arm (North)' or 'Open Arm (South)'). Longer latencies often suggest higher anxiety. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000091 ! timepoint
 
 [Term]
 id: EMPTY:0000019
 name: elevated plus maze: open arm (north) - time moving towards
-def: "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Open Arm (North)' zone, as detected by the tracking software. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Open Arm (North)' zone, as detected by the tracking software. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000020
 name: elevated plus maze: open arm (south) - time moving towards
-def: "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Open Arm (South)' zone, as detected by the tracking software. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Open Arm (South)' zone, as detected by the tracking software. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000021
 name: elevated plus maze: open arm total time moving towards
-def: "In the Elevated Plus Maze task, this is the cumulative duration the animal spends actively moving towards any of the designated open arm zones (e.g., 'Open Arm (North)' or 'Open Arm (South)'), reflecting approach motivation. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this is the cumulative duration the animal spends actively moving towards any of the designated open arm zones (e.g., 'Open Arm (North)' or 'Open Arm (South)'), reflecting approach motivation. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000022
 name: elevated plus maze: open arm (north) - time freezing
-def: "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior (a state of immobility except for respiratory movements) while within the user-defined 'Open Arm (North)' zone. Freezing is a common fear response. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior (a state of immobility except for respiratory movements) while within the user-defined 'Open Arm (North)' zone. Freezing is a common fear response. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000023
 name: elevated plus maze: open arm (south) - time freezing
-def: "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined 'Open Arm (South)' zone. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined 'Open Arm (South)' zone. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000024
 name: elevated plus maze: open arm total time freezing
-def: "In the Elevated Plus Maze task, this is the cumulative duration the animal exhibits freezing behavior while within any of the designated open arm zones (e.g., 'Open Arm (North)' or 'Open Arm (South)'), indicating fear or anxiety. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this is the cumulative duration the animal exhibits freezing behavior while within any of the designated open arm zones (e.g., 'Open Arm (North)' or 'Open Arm (South)'), indicating fear or anxiety. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000025
 name: elevated plus maze: closed arm (west) - entries
-def: "In the Elevated Plus Maze task, this counts the number of times the animal's body fully enters the user-defined 'Closed Arm (West)' zone, representing the enclosed arm designated as 'west'. Unit of measure: count" []
+def: "In the Elevated Plus Maze task, this counts the number of times the animal's body fully enters the user-defined 'Closed Arm (West)' zone, representing the enclosed arm designated as 'west'. Unit: count" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 
 [Term]
 id: EMPTY:0000026
 name: elevated plus maze: closed arm (east) - entries
-def: "In the Elevated Plus Maze task, this counts the number of times the animal's body fully enters the user-defined 'Closed Arm (East)' zone, representing the enclosed arm designated as 'east'. Unit of measure: count" []
+def: "In the Elevated Plus Maze task, this counts the number of times the animal's body fully enters the user-defined 'Closed Arm (East)' zone, representing the enclosed arm designated as 'east'. Unit: count" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 
 [Term]
 id: EMPTY:0000027
 name: elevated plus maze: closed arm total entries
-def: "In the Elevated Plus Maze task, this is the total number of times the animal's body fully enters any of the designated closed arm zones (e.g., 'Closed Arm (West)' and 'Closed Arm (East)'). It is often used as an indicator of general locomotor activity. Unit of measure: count" []
+def: "In the Elevated Plus Maze task, this is the total number of times the animal's body fully enters any of the designated closed arm zones (e.g., 'Closed Arm (West)' and 'Closed Arm (East)'). It is often used as an indicator of general locomotor activity. Unit: count" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 
 [Term]
 id: EMPTY:0000028
 name: elevated plus maze: closed arm (west) - head entries
-def: "In the Elevated Plus Maze task, this counts the number of times the animal's head enters the user-defined 'Closed Arm (West)' zone. Unit of measure: count" []
+def: "In the Elevated Plus Maze task, this counts the number of times the animal's head enters the user-defined 'Closed Arm (West)' zone. Unit: count" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 
 [Term]
 id: EMPTY:0000029
 name: elevated plus maze: closed arm (east) - head entries
-def: "In the Elevated Plus Maze task, this counts the number of times the animal's head enters the user-defined 'Closed Arm (East)' zone. Unit of measure: count" []
+def: "In the Elevated Plus Maze task, this counts the number of times the animal's head enters the user-defined 'Closed Arm (East)' zone. Unit: count" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 
 [Term]
 id: EMPTY:0000030
 name: elevated plus maze: closed arm total head entries
-def: "In the Elevated Plus Maze task, this is the total number of times the animal's head enters any of the designated closed arm zones (e.g., 'Closed Arm (West)' and 'Closed Arm (East)'). Unit of measure: count" []
+def: "In the Elevated Plus Maze task, this is the total number of times the animal's head enters any of the designated closed arm zones (e.g., 'Closed Arm (West)' and 'Closed Arm (East)'). Unit: count" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 
 [Term]
 id: EMPTY:0000031
 name: elevated plus maze: closed arm (west) - time
-def: "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Closed Arm (West)' zone. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Closed Arm (West)' zone. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000032
 name: elevated plus maze: closed arm (east) - time
-def: "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Closed Arm (East)' zone. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Closed Arm (East)' zone. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000033
 name: elevated plus maze: closed arm total time
-def: "In the Elevated Plus Maze task, this is the cumulative total duration the animal's body spends within any of the designated closed arm zones (e.g., 'Closed Arm (West)' and 'Closed Arm (East)'). Animals typically spend more time in these 'safer' areas. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this is the cumulative total duration the animal's body spends within any of the designated closed arm zones (e.g., 'Closed Arm (West)' and 'Closed Arm (East)'). Animals typically spend more time in these 'safer' areas. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000034
 name: elevated plus maze: closed arm total - percent time during test duration
-def: "In the Elevated Plus Maze task, this represents the percentage of the total test duration that the animal spends in any of the designated closed arm zones (e.g., 'Closed Arm (West)' and 'Closed Arm (East)'). Unit of measure: %" []
+def: "In the Elevated Plus Maze task, this represents the percentage of the total test duration that the animal spends in any of the designated closed arm zones (e.g., 'Closed Arm (West)' and 'Closed Arm (East)'). Unit: %" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 
 [Term]
 id: EMPTY:0000035
 name: elevated plus maze: closed arm (west) - latency to first entry
-def: "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Closed Arm (West)' zone. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Closed Arm (West)' zone. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000091 ! timepoint
 
 [Term]
 id: EMPTY:0000036
 name: elevated plus maze: closed arm (east) - latency to first entry
-def: "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Closed Arm (East)' zone. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Closed Arm (East)' zone. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000091 ! timepoint
 
 [Term]
 id: EMPTY:0000037
 name: elevated plus maze: closed arm total latency to first entry
-def: "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into any of the designated closed arm zones (e.g., 'Closed Arm (West)' or 'Closed Arm (East)'). Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into any of the designated closed arm zones (e.g., 'Closed Arm (West)' or 'Closed Arm (East)'). Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000091 ! timepoint
 
 [Term]
 id: EMPTY:0000038
 name: elevated plus maze: closed arm (west) - time moving towards
-def: "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Closed Arm (West)' zone. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Closed Arm (West)' zone. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000039
 name: elevated plus maze: closed arm (east) - time moving towards
-def: "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Closed Arm (East)' zone. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Closed Arm (East)' zone. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000040
 name: elevated plus maze: closed arm total time moving towards
-def: "In the Elevated Plus Maze task, this is the cumulative duration the animal spends actively moving towards any of the designated closed arm zones (e.g., 'Closed Arm (West)' or 'Closed Arm (East)'). Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this is the cumulative duration the animal spends actively moving towards any of the designated closed arm zones (e.g., 'Closed Arm (West)' or 'Closed Arm (East)'). Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000041
 name: elevated plus maze: closed arm (west) - time freezing
-def: "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined 'Closed Arm (West)' zone. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined 'Closed Arm (West)' zone. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000042
 name: elevated plus maze: closed arm (east) - time freezing
-def: "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined 'Closed Arm (East)' zone. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined 'Closed Arm (East)' zone. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000043
 name: elevated plus maze: closed arm total time freezing
-def: "In the Elevated Plus Maze task, this is the cumulative duration the animal exhibits freezing behavior while within any of the designated closed arm zones (e.g., 'Closed Arm (West)' or 'Closed Arm (East)'). Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this is the cumulative duration the animal exhibits freezing behavior while within any of the designated closed arm zones (e.g., 'Closed Arm (West)' or 'Closed Arm (East)'). Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000044
 name: elevated plus maze: center - entries
-def: "In the Elevated Plus Maze task, this counts the number of times the animal's body fully enters the user-defined 'Center' zone of the maze, typically from one of the arms. The center zone is the area where all four arms meet. Unit of measure: count" []
+def: "In the Elevated Plus Maze task, this counts the number of times the animal's body fully enters the user-defined 'Center' zone of the maze, typically from one of the arms. The center zone is the area where all four arms meet. Unit: count" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 
 [Term]
 id: EMPTY:0000045
 name: elevated plus maze: center - head entries
-def: "In the Elevated Plus Maze task, this counts the number of times the animal's head enters the user-defined 'Center' zone of the maze. Unit of measure: count" []
+def: "In the Elevated Plus Maze task, this counts the number of times the animal's head enters the user-defined 'Center' zone of the maze. Unit: count" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 
 [Term]
 id: EMPTY:0000046
 name: elevated plus maze: center - time
-def: "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Center' zone. Time in the center can indicate decision-making or risk assessment. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Center' zone. Time in the center can indicate decision-making or risk assessment. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000047
 name: elevated plus maze: center - percent time during test duration
-def: "In the Elevated Plus Maze task, this represents the percentage of the total test duration that the animal spends in the user-defined 'Center' zone of the maze. Unit of measure: %" []
+def: "In the Elevated Plus Maze task, this represents the percentage of the total test duration that the animal spends in the user-defined 'Center' zone of the maze. Unit: %" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 
 [Term]
 id: EMPTY:0000048
 name: elevated plus maze: center - latency to first entry
-def: "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Center' zone. If the animal starts in the center, this value may be zero or not applicable. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Center' zone. If the animal starts in the center, this value may be zero or not applicable. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000091 ! timepoint
 
 [Term]
 id: EMPTY:0000049
 name: elevated plus maze: center - time moving towards
-def: "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Center' zone of the maze (e.g., from an arm). Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Center' zone of the maze (e.g., from an arm). Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000050
 name: elevated plus maze: center - time freezing
-def: "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined 'Center' zone of the maze. Freezing in this relatively exposed area can indicate high anxiety. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined 'Center' zone of the maze. Freezing in this relatively exposed area can indicate high anxiety. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
@@ -352,7 +352,7 @@ is_a: EMPTY:0000084 ! categorical identifier
 [Term]
 id: EMPTY:0000053
 name: fear-potentiated startle: baseline acoustic startle response amplitude
-def: "In the Fear-potentiated startle paradigm, this is the amplitude of the acoustic startle response (ASR) measured in response to a startle-eliciting stimulus (e.g., 95-dB white noise burst) prior to any fear conditioning procedures, typically assessed during habituation or pre-conditioning phase. This measurement serves as a reference point for later comparisons with post-conditioning startle responses. Unit of measure: arbitrary units or standardized score." []
+def: "In the Fear-potentiated startle paradigm, this is the amplitude of the acoustic startle response (ASR) measured in response to a startle-eliciting stimulus (e.g., 95-dB white noise burst) prior to any fear conditioning procedures, typically assessed during habituation or pre-conditioning phase. This measurement serves as a reference point for later comparisons with post-conditioning startle responses. Unit: arbitrary units or standardized score." []
 is_a: EMPTY:0000004 ! acoustic startle response measurement
 is_a: EMPTY:0000162 ! amplitude
 
@@ -384,7 +384,7 @@ is_a: EMPTY:0000093 ! fear-potentiated startle parameter
 [Term]
 id: EMPTY:0000058
 name: fear-potentiated startle: apparatus chamber identifier
-def: "Identifier for the specific Plexiglas enclosure or sound-attenuating chamber within the Fear-Potentiated Startle (FPS) apparatus (e.g., San Diego Instruments SR-Lab) in which a subject was tested for a given trial. Unit of measure: count or identifier string" []
+def: "Identifier for the specific Plexiglas enclosure or sound-attenuating chamber within the Fear-Potentiated Startle (FPS) apparatus (e.g., San Diego Instruments SR-Lab) in which a subject was tested for a given trial. Unit: count or identifier string" []
 is_a: EMPTY:0000093 ! fear-potentiated startle parameter
 
 [Term]
@@ -396,40 +396,40 @@ is_a: EMPTY:0000084 ! categorical identifier
 [Term]
 id: EMPTY:0000060
 name: acoustic startle response: number of samples
-def: "The total number of data points (samples) recorded and analyzed for a single acoustic startle response, typically within a defined time window following stimulus onset (e.g., a 200-ms window as mentioned in the manuscript). Unit of measure: count" []
+def: "The total number of data points (samples) recorded and analyzed for a single acoustic startle response, typically within a defined time window following stimulus onset (e.g., a 200-ms window as mentioned in the manuscript). Unit: count" []
 is_a: EMPTY:0000093 ! fear-potentiated startle parameter
 
 [Term]
 id: EMPTY:0000061
 name: acoustic startle response: sampling rate
-def: "The rate at which the analog startle response signal was digitized during data acquisition. Unit of measure: Hertz (Hz)" []
+def: "The rate at which the analog startle response signal was digitized during data acquisition. Unit: Hertz (Hz)" []
 is_a: EMPTY:0000093 ! fear-potentiated startle parameter
 
 [Term]
 id: EMPTY:0000062
 name: acoustic startle response: startle window onset amplitude
-def: "The amplitude of the digitized acoustic startle response signal at the very beginning (onset) of the defined analysis window (e.g., a 200-ms window) used to quantify the reflex. Unit of measure: millivolts (mV) or arbitrary units based on transducer calibration." []
+def: "The amplitude of the digitized acoustic startle response signal at the very beginning (onset) of the defined analysis window (e.g., a 200-ms window) used to quantify the reflex. Unit: millivolts (mV) or arbitrary units based on transducer calibration." []
 is_a: EMPTY:0000004 ! acoustic startle response measurement
 is_a: EMPTY:0000162 ! amplitude
 
 [Term]
 id: EMPTY:0000063
 name: acoustic startle response: maximum amplitude
-def: "The peak amplitude of the acoustic startle response (e.g., 'jump amplitude') detected within the defined analysis window (e.g., 200-ms window) for a given trial. Unit of measure: millivolts (mV) or arbitrary units." []
+def: "The peak amplitude of the acoustic startle response (e.g., 'jump amplitude') detected within the defined analysis window (e.g., 200-ms window) for a given trial. Unit: millivolts (mV) or arbitrary units." []
 is_a: EMPTY:0000004 ! acoustic startle response measurement
 is_a: EMPTY:0000162 ! amplitude
 
 [Term]
 id: EMPTY:0000064
 name: acoustic startle response: time to maximum amplitude
-def: "The latency from the onset of the startle-eliciting stimulus (or the beginning of the analysis window) to the occurrence of the maximum (peak) amplitude of the acoustic startle response. Unit of measure: milliseconds (ms)" []
+def: "The latency from the onset of the startle-eliciting stimulus (or the beginning of the analysis window) to the occurrence of the maximum (peak) amplitude of the acoustic startle response. Unit: milliseconds (ms)" []
 is_a: EMPTY:0000004 ! acoustic startle response measurement
 is_a: EMPTY:0000091 ! timepoint
 
 [Term]
 id: EMPTY:0000065
 name: acoustic startle response: average amplitude
-def: "The average amplitude of the digitized acoustic startle response signal calculated across the entire duration of the defined analysis window (e.g., 200-ms window). Unit of measure: millivolts (mV) or arbitrary units." []
+def: "The average amplitude of the digitized acoustic startle response signal calculated across the entire duration of the defined analysis window (e.g., 200-ms window). Unit: millivolts (mV) or arbitrary units." []
 is_a: EMPTY:0000004 ! acoustic startle response measurement
 is_a: EMPTY:0000162 ! amplitude
 
@@ -449,7 +449,7 @@ is_a: EMPTY:0000093 ! fear-potentiated startle parameter
 [Term]
 id: EMPTY:0000068
 name: elevated plus maze: test duration
-def: "In the Elevated Plus Maze task, this is the time of the total test duration in seconds'). Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this is the time of the total test duration in seconds'). Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 is_a: EMPTY:0000092 ! elevated plus maze parameter
@@ -1120,13 +1120,13 @@ is_a: EMPTY:0000164 ! contextual fear conditioning parameter
 [Term]
 id: EMPTY:0000175
 name: contextual fear conditioning: time freezing
-def: "The number of seconds the individual spent freezing during a given period of time. Unit of measure: seconds" []
+def: "The number of seconds the individual spent freezing during a given period of time. Unit: seconds" []
 is_a: EMPTY:0000163 ! contextual fear conditioning measurement
 
 [Term]
 id: EMPTY:0000176
 name: contextual fear conditioning: block duration
-def: "In the contextual fear conditioning paradigm, this is the time of the block duration in seconds. Unit of measure: seconds" []
+def: "In the contextual fear conditioning paradigm, this is the time of the block duration in seconds. Unit: seconds" []
 is_a: EMPTY:0000163 ! contextual fear conditioning measurement
 is_a: EMPTY:0000164 ! contextual fear conditioning parameter
 
@@ -1450,3 +1450,169 @@ id: EMPTY:0000230
 name: unknown electronic file type
 def: "A digital file for which the format, encoding, or origin cannot be definitively identified by the system or investigator, necessitating further manual review or specialized software for interpretation." []
 
+[Term]
+id: EMPTY:0000231
+name: C. elegans chemotaxis assay parameter
+def: "A parameter that specifies the technical settings, environmental conditions, or experimental design of a chemotaxis assay involving Caenorhabditis elegans." []
+is_a: EMPTY:0000101 ! C. elegans behavioral assay parameter
+
+[Term]
+id: EMPTY:0000232
+name: C. elegans chemotaxis assay parameter: chemoattractant mixture table
+def: "A table containing the quantities and identities of all chemicals used as a chemoattractant (e.g., isoamyl alcohol, diacetyl) to elicit a directed movement response in C. elegans." []
+is_a: EMPTY:0000231 ! C. elegans chemotaxis assay parameter
+
+[Term]
+id: EMPTY:0000233
+name: C. elegans chemotaxis assay parameter: chemoattractant mixture volume
+def: "The volume of the chemoattractant mixture pipetted onto the agar plate in a chemotaxis assay. Unit: microliters (μL)." []
+is_a: EMPTY:0000231 ! C. elegans chemotaxis assay parameter
+
+[Term]
+id: EMPTY:0000234
+name: C. elegans chemotaxis assay parameter: assay duration
+def: "The total time elapsed from the point at which C. elegans are placed on the assay plate until the movement is arrested or the final positions are recorded. Unit: minutes." []
+is_a: EMPTY:0000231 ! C. elegans chemotaxis assay parameter
+
+[Term]
+id: EMPTY:0000235
+name: C. elegans chemotaxis assay measurement
+def: "A quantitative or qualitative value derived from a C. elegans chemotaxis assay, typically describing the efficiency or directionality of the animals' movement toward or away from a chemical source." []
+is_a: EMPTY:0000100 ! C. elegans behavioral assay measurement
+
+[Term]
+id: EMPTY:0000236
+name: C. elegans chemotaxis assay measurement: McCutcheon index
+def: "A behavioral measurement of chemotactic efficiency defined as the ratio of the straight-line displacement toward the attractant to the total path length traveled by the organism. Values range from -1 to 1." []
+synonym: "chemotactic ratio" EXACT []
+is_a: EMPTY:0000235 ! C. elegans chemotaxis assay measurement
+
+[Term]
+id: EMPTY:0000237
+name: C. elegans chemotaxis assay measurement: mean velocity
+def: "The average speed of a C. elegans individual or population during the duration of the chemotaxis assay. Unit: micrometers per second (µm/s)." []
+is_a: EMPTY:0000235 ! C. elegans chemotaxis assay measurement
+
+[Term]
+id: EMPTY:0000238
+name: investigator-defined strain
+def: "A specific genetic variant or line of an organism designated by the investigator, often containing unique mutations, transgenes, or genomic edits not yet categorized in a public repository." []
+is_a: EMPTY:0000076 ! descriptor
+
+[Term]
+id: EMPTY:0000239
+name: C. elegans strain
+def: "A specific strain of Caenorhabditis elegans, identified by its genotype or a standard nomenclature (e.g., N2, CB4856), used in experimental procedures." []
+is_a: EMPTY:0000238 ! investigator-defined strain
+
+[Term]
+id: EMPTY:0000240
+name: BAB9001
+def: "A C. elegans strain with the genotype daf-22 (m130). This strain was originally obtained from the Caenorhabditis Genetics Center (CGC) as strain DR476 and subsequently outcrossed three times. [Source: https://doi.org/TBD]" []
+is_a: EMPTY:0000239 ! C. elegans strain
+
+[Term]
+id: EMPTY:0000241
+name: BAB9002
+def: "A C. elegans klp-6 rescue strain with the genotype klp-6 (my8); Pklp-6::GFP::KLP-6 (array, IndEx 9002). [Source: https://doi.org/TBD]" []
+is_a: EMPTY:0000239 ! C. elegans strain
+
+[Term]
+id: EMPTY:0000242
+name: TM5848
+def: "A C. elegans strain with the genotype cil-7 (tm5848) I, exhibiting a him phenotype. This strain was obtained from the National BioResource Project (NBRP), Japan. [Source: https://doi.org/TBD]" []
+is_a: EMPTY:0000239 ! C. elegans strain
+
+[Term]
+id: EMPTY:0000243
+name: PT3602
+def: "A C. elegans strain with the genotype cil-7 (my61[cil-7::mNG])I; him-5(e1490) V. This strain was provided as a gift from the Maureen Barr lab. [Source: https://doi.org/TBD]" []
+is_a: EMPTY:0000239 ! C. elegans strain
+
+[Term]
+id: EMPTY:0000244
+name: BAB9003
+def: "A C. elegans strain with the genotype PT3602; Pnlp-43_hCaspase nZ (array IndEx 9003). [Source: https://doi.org/TBD]" []
+is_a: EMPTY:0000239 ! C. elegans strain
+
+[Term]
+id: EMPTY:0000245
+name: BAB9004
+def: "A C. elegans strain with the genotype PT3602; Pklp-6_hCaspase Cz (array IndEx 9004). [Source: https://doi.org/TBD]" []
+is_a: EMPTY:0000239 ! C. elegans strain
+
+[Term]
+id: EMPTY:0000246
+name: BAB9005
+def: "A C. elegans strain with the genotype PT3602; Pnlp-43_hCaspase nZ (array IndEx 9003) and Pklp-6_hCaspase Cz (array IndEx 9004). [Source: https://doi.org/TBD]" []
+is_a: EMPTY:0000239 ! C. elegans strain
+
+[Term]
+id: EMPTY:0000247
+name: fluorescence imaging measurement
+def: "fluorescence imaging measurement" []
+is_a: EMPTY:0000001 ! measurement
+
+[Term]
+id: EMPTY:0000248
+name: mean fluorescence intensity
+def: "Mean fluorescence intensity. Unit: arbitrary units (AU)" []
+is_a: EMPTY:0000247 ! fluorescence imaging measurement
+
+[Term]
+id: EMPTY:0000249
+name: fluorescent punctal count
+def: "A quantitative measurement of the number of distinct fluorescent spots or puncta detected within a defined region of interest in a fluorescence image. Unit: count" []
+is_a: EMPTY:0000247 ! fluorescence imaging measurement
+
+[Term]
+id: EMPTY:0000250
+name: fluorescence imaging parameter
+def: "A specific parameter related to fluorescence imaging acquisition or assay." []
+is_a: EMPTY:0000080 ! parameter
+
+[Term]
+id: EMPTY:0000251
+name: fluorescence target ontology identifier
+def: "fluorescence target ontology identifier" []
+is_a: EMPTY:0000250 ! fluorescence imaging parameter
+
+[Term]
+id: EMPTY:0000252
+name: fluorescence target name
+def: "fluorescence target name" []
+is_a: EMPTY:0000250 ! fluorescence imaging parameter
+
+[Term]
+id: EMPTY:0000253
+name: SnapGene file format
+def: "A .dna file format designed for storing annotated DNA sequences, including linear/circular topology, features, primers, and enzyme sites." []
+
+[Term]
+id: EMPTY:0000254
+name: Escherichia coli OP50: heat-killed
+def: "A preparation of Escherichia coli strain OP50 that has been rendered non-viable through the application of heat, typically used as a non-proliferating food source in C. elegans assays." []
+
+[Term]
+id: EMPTY:0000255
+name: C. elegans transfer method: M9 buffer wash
+def: "Method used to transfer C. elegans whereby an M9 buffer is used to wash C. elegans off of an agar plate. Animals can then be transferred using a piper." []
+is_a: EMPTY:0000189 ! treatment
+
+[Term]
+id: EMPTY:0000256
+name: C. elegans transfer method: titanium pick
+def: "Method used to transfer C. elegans whereby a titanium pick is used to scoop animals off of an agar plate." []
+is_a: EMPTY:0000189 ! treatment
+
+[Term]
+id: EMPTY:0000257
+name: C. elegans chemotaxis assay: video recording
+def: "A video recording capturing the behavior of C. elegans during a chemotaxis assay." []
+is_a: EMPTY:0000129 ! C. elegans behavioral assay: video recording
+
+[Term]
+id: EMPTY:0000258
+name: fluorescence imaging data
+def: "An image or video acquired using fluorescence microscopy." []
+
diff --git a/empty-simple.owl b/empty-simple.owl
index dd8e819..be112aa 100644
--- a/empty-simple.owl
+++ b/empty-simple.owl
@@ -10,13 +10,13 @@
      xmlns:terms="http://purl.org/dc/terms/"
      xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#">
     <owl:Ontology rdf:about="http://purl.obolibrary.org/obo/empty/empty-simple.owl">
-        <owl:versionIRI rdf:resource="http://purl.obolibrary.org/obo/empty/releases/2026-02-23/empty-simple.owl"/>
+        <owl:versionIRI rdf:resource="http://purl.obolibrary.org/obo/empty/releases/2026-04-04/empty-simple.owl"/>
         <terms:description>An ontology of experimental measurements in the sciences, the purposes for which experimental measurements were made, and experimental treatments, with a focus on life sciences.</terms:description>
         <terms:license rdf:resource="https://creativecommons.org/licenses/by/4.0/"/>
         <terms:title>Experimental Measurements Purposes and Treatments ontologY</terms:title>
         <rdfs:comment>EMPTY by NDI is licensed under CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/). You are free to share (copy and redistribute the material in any medium or format) and adapt (remix, transform, and build upon the material) for any purpose, even commercially. You must give appropriate credit (by using the original ontology IRI for the whole ontology or original term IRIs for individual terms), provide a link to the license, and indicate if any changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.</rdfs:comment>
         <owl:versionInfo>Release 2025-07-10</owl:versionInfo>
-        <owl:versionInfo>2026-02-23</owl:versionInfo>
+        <owl:versionInfo>2026-04-04</owl:versionInfo>
     </owl:Ontology>
     
 
@@ -35,8 +35,11 @@
     <!-- http://purl.obolibrary.org/obo/IAO_0000115 -->
 
     <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000115">
+        <obo:IAO_0000115>A property representing the English language definitions of what NCI means by the concept. They may also include information about the definition&apos;s source and attribution in a form that can easily be interpreted by software.</obo:IAO_0000115>
+        <obo:IAO_0000115>English language definitions of what NCI means by the concept. These are limited to 1024 characters. They may also include information about the definition&apos;s source and attribution in a form that can easily be interpreted by software.</obo:IAO_0000115>
         <obo:IAO_0000115 xml:lang="en">The official OBI definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions.</obo:IAO_0000115>
         <obo:IAO_0000115 xml:lang="en">The official definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions.</obo:IAO_0000115>
+        <obo:IAO_0000115>The official definition.</obo:IAO_0000115>
         <rdfs:label>definition</rdfs:label>
         <rdfs:label xml:lang="en">definition</rdfs:label>
         <rdfs:label>textual definition</rdfs:label>
@@ -152,7 +155,7 @@
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000006">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s body (typically defined by its center point or a significant portion) fully enters the user-defined zone designated as &apos;Open Arm (North)&apos;. The &apos;Open Arm (North)&apos; is one of the two open arms, distinguished by its assigned &apos;north&apos; orientation or designation in the experimental setup. Unit of measure: count</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s body (typically defined by its center point or a significant portion) fully enters the user-defined zone designated as &apos;Open Arm (North)&apos;. The &apos;Open Arm (North)&apos; is one of the two open arms, distinguished by its assigned &apos;north&apos; orientation or designation in the experimental setup. Unit: count</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: open arm (north) - entries</rdfs:label>
     </owl:Class>
     
@@ -162,7 +165,7 @@
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000007">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s body (typically defined by its center point or a significant portion) fully enters the user-defined zone designated as &apos;Open Arm (South)&apos;. The &apos;Open Arm (South)&apos; is one of the two open arms, distinguished by its assigned &apos;south&apos; orientation or designation in the experimental setup. Unit of measure: count</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s body (typically defined by its center point or a significant portion) fully enters the user-defined zone designated as &apos;Open Arm (South)&apos;. The &apos;Open Arm (South)&apos; is one of the two open arms, distinguished by its assigned &apos;south&apos; orientation or designation in the experimental setup. Unit: count</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: open arm (south) - entries</rdfs:label>
     </owl:Class>
     
@@ -172,7 +175,7 @@
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000008">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this represents the total number of times the animal&apos;s body (typically defined by its center point or a significant portion) fully enters the designated open arm zones (e.g., &apos;Open Arm (North)&apos; and &apos;Open Arm (South)&apos;). It is a common measure of exploration and anxiety. Unit of measure: count</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this represents the total number of times the animal&apos;s body (typically defined by its center point or a significant portion) fully enters the designated open arm zones (e.g., &apos;Open Arm (North)&apos; and &apos;Open Arm (South)&apos;). It is a common measure of exploration and anxiety. Unit: count</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: open arm total entries</rdfs:label>
     </owl:Class>
     
@@ -182,7 +185,7 @@
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000009">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s head (specifically tracked by the software) enters the user-defined &apos;Open Arm (North)&apos; zone, irrespective of full body entry. This can indicate risk assessment or tentative exploration of the arm designated as &apos;north&apos;. Unit of measure: count</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s head (specifically tracked by the software) enters the user-defined &apos;Open Arm (North)&apos; zone, irrespective of full body entry. This can indicate risk assessment or tentative exploration of the arm designated as &apos;north&apos;. Unit: count</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: open arm (north) - head entries</rdfs:label>
     </owl:Class>
     
@@ -192,7 +195,7 @@
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000010">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s head (specifically tracked by the software) enters the user-defined &apos;Open Arm (South)&apos; zone, irrespective of full body entry, often reflecting cautious exploration of the open arm designated as &apos;south&apos;. Unit of measure: count</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s head (specifically tracked by the software) enters the user-defined &apos;Open Arm (South)&apos; zone, irrespective of full body entry, often reflecting cautious exploration of the open arm designated as &apos;south&apos;. Unit: count</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: open arm (south) - head entries</rdfs:label>
     </owl:Class>
     
@@ -202,7 +205,7 @@
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000011">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the total number of times the animal&apos;s head (specifically tracked by the software) enters any of the designated open arm zones (e.g., &apos;Open Arm (North)&apos; and &apos;Open Arm (South)&apos;), considered an indicator of risk-assessment behavior. Unit of measure: count</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the total number of times the animal&apos;s head (specifically tracked by the software) enters any of the designated open arm zones (e.g., &apos;Open Arm (North)&apos; and &apos;Open Arm (South)&apos;), considered an indicator of risk-assessment behavior. Unit: count</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: open arm total head entries</rdfs:label>
     </owl:Class>
     
@@ -213,7 +216,7 @@
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000012">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal&apos;s body spends within the user-defined &apos;Open Arm (North)&apos; zone. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal&apos;s body spends within the user-defined &apos;Open Arm (North)&apos; zone. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: open arm (north) - time</rdfs:label>
     </owl:Class>
     
@@ -224,7 +227,7 @@
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000013">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal&apos;s body spends within the user-defined &apos;Open Arm (South)&apos; zone. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal&apos;s body spends within the user-defined &apos;Open Arm (South)&apos; zone. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: open arm (south) - time</rdfs:label>
     </owl:Class>
     
@@ -235,7 +238,7 @@
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000014">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the cumulative total duration the animal&apos;s body spends within any of the designated open arm zones (e.g., &apos;Open Arm (North)&apos; and &apos;Open Arm (South)&apos;). Less time is generally indicative of higher anxiety. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the cumulative total duration the animal&apos;s body spends within any of the designated open arm zones (e.g., &apos;Open Arm (North)&apos; and &apos;Open Arm (South)&apos;). Less time is generally indicative of higher anxiety. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: open arm total time</rdfs:label>
     </owl:Class>
     
@@ -245,7 +248,7 @@
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000015">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this represents the percentage of the total test duration that the animal spends in any of the designated open arm zones (e.g., &apos;Open Arm (North)&apos; and &apos;Open Arm (South)&apos;). Unit of measure: %</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this represents the percentage of the total test duration that the animal spends in any of the designated open arm zones (e.g., &apos;Open Arm (North)&apos; and &apos;Open Arm (South)&apos;). Unit: %</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: open arm total - percent time during test duration</rdfs:label>
     </owl:Class>
     
@@ -256,7 +259,7 @@
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000016">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000091"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined &apos;Open Arm (North)&apos; zone. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined &apos;Open Arm (North)&apos; zone. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: open arm (north) - latency to first entry</rdfs:label>
     </owl:Class>
     
@@ -267,7 +270,7 @@
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000017">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000091"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined &apos;Open Arm (South)&apos; zone. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined &apos;Open Arm (South)&apos; zone. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: open arm (south) - latency to first entry</rdfs:label>
     </owl:Class>
     
@@ -278,7 +281,7 @@
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000018">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000091"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into any of the designated open arm zones (e.g., &apos;Open Arm (North)&apos; or &apos;Open Arm (South)&apos;). Longer latencies often suggest higher anxiety. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into any of the designated open arm zones (e.g., &apos;Open Arm (North)&apos; or &apos;Open Arm (South)&apos;). Longer latencies often suggest higher anxiety. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: open arm total latency to first entry</rdfs:label>
     </owl:Class>
     
@@ -289,7 +292,7 @@
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000019">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined &apos;Open Arm (North)&apos; zone, as detected by the tracking software. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined &apos;Open Arm (North)&apos; zone, as detected by the tracking software. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: open arm (north) - time moving towards</rdfs:label>
     </owl:Class>
     
@@ -300,7 +303,7 @@
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000020">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined &apos;Open Arm (South)&apos; zone, as detected by the tracking software. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined &apos;Open Arm (South)&apos; zone, as detected by the tracking software. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: open arm (south) - time moving towards</rdfs:label>
     </owl:Class>
     
@@ -311,7 +314,7 @@
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000021">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the cumulative duration the animal spends actively moving towards any of the designated open arm zones (e.g., &apos;Open Arm (North)&apos; or &apos;Open Arm (South)&apos;), reflecting approach motivation. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the cumulative duration the animal spends actively moving towards any of the designated open arm zones (e.g., &apos;Open Arm (North)&apos; or &apos;Open Arm (South)&apos;), reflecting approach motivation. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: open arm total time moving towards</rdfs:label>
     </owl:Class>
     
@@ -322,7 +325,7 @@
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000022">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior (a state of immobility except for respiratory movements) while within the user-defined &apos;Open Arm (North)&apos; zone. Freezing is a common fear response. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior (a state of immobility except for respiratory movements) while within the user-defined &apos;Open Arm (North)&apos; zone. Freezing is a common fear response. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: open arm (north) - time freezing</rdfs:label>
     </owl:Class>
     
@@ -333,7 +336,7 @@
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000023">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined &apos;Open Arm (South)&apos; zone. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined &apos;Open Arm (South)&apos; zone. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: open arm (south) - time freezing</rdfs:label>
     </owl:Class>
     
@@ -344,7 +347,7 @@
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000024">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the cumulative duration the animal exhibits freezing behavior while within any of the designated open arm zones (e.g., &apos;Open Arm (North)&apos; or &apos;Open Arm (South)&apos;), indicating fear or anxiety. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the cumulative duration the animal exhibits freezing behavior while within any of the designated open arm zones (e.g., &apos;Open Arm (North)&apos; or &apos;Open Arm (South)&apos;), indicating fear or anxiety. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: open arm total time freezing</rdfs:label>
     </owl:Class>
     
@@ -354,7 +357,7 @@
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000025">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s body fully enters the user-defined &apos;Closed Arm (West)&apos; zone, representing the enclosed arm designated as &apos;west&apos;. Unit of measure: count</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s body fully enters the user-defined &apos;Closed Arm (West)&apos; zone, representing the enclosed arm designated as &apos;west&apos;. Unit: count</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: closed arm (west) - entries</rdfs:label>
     </owl:Class>
     
@@ -364,7 +367,7 @@
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000026">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s body fully enters the user-defined &apos;Closed Arm (East)&apos; zone, representing the enclosed arm designated as &apos;east&apos;. Unit of measure: count</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s body fully enters the user-defined &apos;Closed Arm (East)&apos; zone, representing the enclosed arm designated as &apos;east&apos;. Unit: count</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: closed arm (east) - entries</rdfs:label>
     </owl:Class>
     
@@ -374,7 +377,7 @@
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000027">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the total number of times the animal&apos;s body fully enters any of the designated closed arm zones (e.g., &apos;Closed Arm (West)&apos; and &apos;Closed Arm (East)&apos;). It is often used as an indicator of general locomotor activity. Unit of measure: count</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the total number of times the animal&apos;s body fully enters any of the designated closed arm zones (e.g., &apos;Closed Arm (West)&apos; and &apos;Closed Arm (East)&apos;). It is often used as an indicator of general locomotor activity. Unit: count</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: closed arm total entries</rdfs:label>
     </owl:Class>
     
@@ -384,7 +387,7 @@
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000028">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s head enters the user-defined &apos;Closed Arm (West)&apos; zone. Unit of measure: count</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s head enters the user-defined &apos;Closed Arm (West)&apos; zone. Unit: count</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: closed arm (west) - head entries</rdfs:label>
     </owl:Class>
     
@@ -394,7 +397,7 @@
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000029">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s head enters the user-defined &apos;Closed Arm (East)&apos; zone. Unit of measure: count</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s head enters the user-defined &apos;Closed Arm (East)&apos; zone. Unit: count</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: closed arm (east) - head entries</rdfs:label>
     </owl:Class>
     
@@ -404,7 +407,7 @@
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000030">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the total number of times the animal&apos;s head enters any of the designated closed arm zones (e.g., &apos;Closed Arm (West)&apos; and &apos;Closed Arm (East)&apos;). Unit of measure: count</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the total number of times the animal&apos;s head enters any of the designated closed arm zones (e.g., &apos;Closed Arm (West)&apos; and &apos;Closed Arm (East)&apos;). Unit: count</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: closed arm total head entries</rdfs:label>
     </owl:Class>
     
@@ -415,7 +418,7 @@
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000031">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal&apos;s body spends within the user-defined &apos;Closed Arm (West)&apos; zone. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal&apos;s body spends within the user-defined &apos;Closed Arm (West)&apos; zone. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: closed arm (west) - time</rdfs:label>
     </owl:Class>
     
@@ -426,7 +429,7 @@
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000032">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal&apos;s body spends within the user-defined &apos;Closed Arm (East)&apos; zone. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal&apos;s body spends within the user-defined &apos;Closed Arm (East)&apos; zone. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: closed arm (east) - time</rdfs:label>
     </owl:Class>
     
@@ -437,7 +440,7 @@
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000033">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the cumulative total duration the animal&apos;s body spends within any of the designated closed arm zones (e.g., &apos;Closed Arm (West)&apos; and &apos;Closed Arm (East)&apos;). Animals typically spend more time in these &apos;safer&apos; areas. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the cumulative total duration the animal&apos;s body spends within any of the designated closed arm zones (e.g., &apos;Closed Arm (West)&apos; and &apos;Closed Arm (East)&apos;). Animals typically spend more time in these &apos;safer&apos; areas. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: closed arm total time</rdfs:label>
     </owl:Class>
     
@@ -447,7 +450,7 @@
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000034">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this represents the percentage of the total test duration that the animal spends in any of the designated closed arm zones (e.g., &apos;Closed Arm (West)&apos; and &apos;Closed Arm (East)&apos;). Unit of measure: %</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this represents the percentage of the total test duration that the animal spends in any of the designated closed arm zones (e.g., &apos;Closed Arm (West)&apos; and &apos;Closed Arm (East)&apos;). Unit: %</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: closed arm total - percent time during test duration</rdfs:label>
     </owl:Class>
     
@@ -458,7 +461,7 @@
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000035">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000091"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined &apos;Closed Arm (West)&apos; zone. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined &apos;Closed Arm (West)&apos; zone. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: closed arm (west) - latency to first entry</rdfs:label>
     </owl:Class>
     
@@ -469,7 +472,7 @@
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000036">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000091"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined &apos;Closed Arm (East)&apos; zone. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined &apos;Closed Arm (East)&apos; zone. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: closed arm (east) - latency to first entry</rdfs:label>
     </owl:Class>
     
@@ -480,7 +483,7 @@
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000037">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000091"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into any of the designated closed arm zones (e.g., &apos;Closed Arm (West)&apos; or &apos;Closed Arm (East)&apos;). Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into any of the designated closed arm zones (e.g., &apos;Closed Arm (West)&apos; or &apos;Closed Arm (East)&apos;). Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: closed arm total latency to first entry</rdfs:label>
     </owl:Class>
     
@@ -491,7 +494,7 @@
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000038">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined &apos;Closed Arm (West)&apos; zone. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined &apos;Closed Arm (West)&apos; zone. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: closed arm (west) - time moving towards</rdfs:label>
     </owl:Class>
     
@@ -502,7 +505,7 @@
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000039">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined &apos;Closed Arm (East)&apos; zone. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined &apos;Closed Arm (East)&apos; zone. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: closed arm (east) - time moving towards</rdfs:label>
     </owl:Class>
     
@@ -513,7 +516,7 @@
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000040">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the cumulative duration the animal spends actively moving towards any of the designated closed arm zones (e.g., &apos;Closed Arm (West)&apos; or &apos;Closed Arm (East)&apos;). Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the cumulative duration the animal spends actively moving towards any of the designated closed arm zones (e.g., &apos;Closed Arm (West)&apos; or &apos;Closed Arm (East)&apos;). Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: closed arm total time moving towards</rdfs:label>
     </owl:Class>
     
@@ -524,7 +527,7 @@
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000041">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined &apos;Closed Arm (West)&apos; zone. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined &apos;Closed Arm (West)&apos; zone. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: closed arm (west) - time freezing</rdfs:label>
     </owl:Class>
     
@@ -535,7 +538,7 @@
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000042">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined &apos;Closed Arm (East)&apos; zone. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined &apos;Closed Arm (East)&apos; zone. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: closed arm (east) - time freezing</rdfs:label>
     </owl:Class>
     
@@ -546,7 +549,7 @@
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000043">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the cumulative duration the animal exhibits freezing behavior while within any of the designated closed arm zones (e.g., &apos;Closed Arm (West)&apos; or &apos;Closed Arm (East)&apos;). Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the cumulative duration the animal exhibits freezing behavior while within any of the designated closed arm zones (e.g., &apos;Closed Arm (West)&apos; or &apos;Closed Arm (East)&apos;). Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: closed arm total time freezing</rdfs:label>
     </owl:Class>
     
@@ -556,7 +559,7 @@
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000044">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s body fully enters the user-defined &apos;Center&apos; zone of the maze, typically from one of the arms. The center zone is the area where all four arms meet. Unit of measure: count</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s body fully enters the user-defined &apos;Center&apos; zone of the maze, typically from one of the arms. The center zone is the area where all four arms meet. Unit: count</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: center - entries</rdfs:label>
     </owl:Class>
     
@@ -566,7 +569,7 @@
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000045">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s head enters the user-defined &apos;Center&apos; zone of the maze. Unit of measure: count</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s head enters the user-defined &apos;Center&apos; zone of the maze. Unit: count</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: center - head entries</rdfs:label>
     </owl:Class>
     
@@ -577,7 +580,7 @@
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000046">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal&apos;s body spends within the user-defined &apos;Center&apos; zone. Time in the center can indicate decision-making or risk assessment. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal&apos;s body spends within the user-defined &apos;Center&apos; zone. Time in the center can indicate decision-making or risk assessment. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: center - time</rdfs:label>
     </owl:Class>
     
@@ -587,7 +590,7 @@
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000047">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this represents the percentage of the total test duration that the animal spends in the user-defined &apos;Center&apos; zone of the maze. Unit of measure: %</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this represents the percentage of the total test duration that the animal spends in the user-defined &apos;Center&apos; zone of the maze. Unit: %</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: center - percent time during test duration</rdfs:label>
     </owl:Class>
     
@@ -598,7 +601,7 @@
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000048">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000091"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined &apos;Center&apos; zone. If the animal starts in the center, this value may be zero or not applicable. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined &apos;Center&apos; zone. If the animal starts in the center, this value may be zero or not applicable. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: center - latency to first entry</rdfs:label>
     </owl:Class>
     
@@ -609,7 +612,7 @@
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000049">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined &apos;Center&apos; zone of the maze (e.g., from an arm). Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined &apos;Center&apos; zone of the maze (e.g., from an arm). Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: center - time moving towards</rdfs:label>
     </owl:Class>
     
@@ -620,7 +623,7 @@
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000050">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined &apos;Center&apos; zone of the maze. Freezing in this relatively exposed area can indicate high anxiety. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined &apos;Center&apos; zone of the maze. Freezing in this relatively exposed area can indicate high anxiety. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: center - time freezing</rdfs:label>
     </owl:Class>
     
@@ -651,7 +654,7 @@
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000053">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000004"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000162"/>
-        <obo:IAO_0000115>In the Fear-potentiated startle paradigm, this is the amplitude of the acoustic startle response (ASR) measured in response to a startle-eliciting stimulus (e.g., 95-dB white noise burst) prior to any fear conditioning procedures, typically assessed during habituation or pre-conditioning phase. This measurement serves as a reference point for later comparisons with post-conditioning startle responses. Unit of measure: arbitrary units or standardized score.</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Fear-potentiated startle paradigm, this is the amplitude of the acoustic startle response (ASR) measured in response to a startle-eliciting stimulus (e.g., 95-dB white noise burst) prior to any fear conditioning procedures, typically assessed during habituation or pre-conditioning phase. This measurement serves as a reference point for later comparisons with post-conditioning startle responses. Unit: arbitrary units or standardized score.</obo:IAO_0000115>
         <rdfs:label xml:lang="en">fear-potentiated startle: baseline acoustic startle response amplitude</rdfs:label>
     </owl:Class>
     
@@ -702,7 +705,7 @@
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000058">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000093"/>
-        <obo:IAO_0000115>Identifier for the specific Plexiglas enclosure or sound-attenuating chamber within the Fear-Potentiated Startle (FPS) apparatus (e.g., San Diego Instruments SR-Lab) in which a subject was tested for a given trial. Unit of measure: count or identifier string</obo:IAO_0000115>
+        <obo:IAO_0000115>Identifier for the specific Plexiglas enclosure or sound-attenuating chamber within the Fear-Potentiated Startle (FPS) apparatus (e.g., San Diego Instruments SR-Lab) in which a subject was tested for a given trial. Unit: count or identifier string</obo:IAO_0000115>
         <rdfs:label xml:lang="en">fear-potentiated startle: apparatus chamber identifier</rdfs:label>
     </owl:Class>
     
@@ -722,7 +725,7 @@
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000060">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000093"/>
-        <obo:IAO_0000115>The total number of data points (samples) recorded and analyzed for a single acoustic startle response, typically within a defined time window following stimulus onset (e.g., a 200-ms window as mentioned in the manuscript). Unit of measure: count</obo:IAO_0000115>
+        <obo:IAO_0000115>The total number of data points (samples) recorded and analyzed for a single acoustic startle response, typically within a defined time window following stimulus onset (e.g., a 200-ms window as mentioned in the manuscript). Unit: count</obo:IAO_0000115>
         <rdfs:label xml:lang="en">acoustic startle response: number of samples</rdfs:label>
     </owl:Class>
     
@@ -732,7 +735,7 @@
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000061">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000093"/>
-        <obo:IAO_0000115>The rate at which the analog startle response signal was digitized during data acquisition. Unit of measure: Hertz (Hz)</obo:IAO_0000115>
+        <obo:IAO_0000115>The rate at which the analog startle response signal was digitized during data acquisition. Unit: Hertz (Hz)</obo:IAO_0000115>
         <rdfs:label xml:lang="en">acoustic startle response: sampling rate</rdfs:label>
     </owl:Class>
     
@@ -743,7 +746,7 @@
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000062">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000004"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000162"/>
-        <obo:IAO_0000115>The amplitude of the digitized acoustic startle response signal at the very beginning (onset) of the defined analysis window (e.g., a 200-ms window) used to quantify the reflex. Unit of measure: millivolts (mV) or arbitrary units based on transducer calibration.</obo:IAO_0000115>
+        <obo:IAO_0000115>The amplitude of the digitized acoustic startle response signal at the very beginning (onset) of the defined analysis window (e.g., a 200-ms window) used to quantify the reflex. Unit: millivolts (mV) or arbitrary units based on transducer calibration.</obo:IAO_0000115>
         <rdfs:label xml:lang="en">acoustic startle response: startle window onset amplitude</rdfs:label>
     </owl:Class>
     
@@ -754,7 +757,7 @@
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000063">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000004"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000162"/>
-        <obo:IAO_0000115>The peak amplitude of the acoustic startle response (e.g., &apos;jump amplitude&apos;) detected within the defined analysis window (e.g., 200-ms window) for a given trial. Unit of measure: millivolts (mV) or arbitrary units.</obo:IAO_0000115>
+        <obo:IAO_0000115>The peak amplitude of the acoustic startle response (e.g., &apos;jump amplitude&apos;) detected within the defined analysis window (e.g., 200-ms window) for a given trial. Unit: millivolts (mV) or arbitrary units.</obo:IAO_0000115>
         <rdfs:label xml:lang="en">acoustic startle response: maximum amplitude</rdfs:label>
     </owl:Class>
     
@@ -765,7 +768,7 @@
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000064">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000004"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000091"/>
-        <obo:IAO_0000115>The latency from the onset of the startle-eliciting stimulus (or the beginning of the analysis window) to the occurrence of the maximum (peak) amplitude of the acoustic startle response. Unit of measure: milliseconds (ms)</obo:IAO_0000115>
+        <obo:IAO_0000115>The latency from the onset of the startle-eliciting stimulus (or the beginning of the analysis window) to the occurrence of the maximum (peak) amplitude of the acoustic startle response. Unit: milliseconds (ms)</obo:IAO_0000115>
         <rdfs:label xml:lang="en">acoustic startle response: time to maximum amplitude</rdfs:label>
     </owl:Class>
     
@@ -776,7 +779,7 @@
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000065">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000004"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000162"/>
-        <obo:IAO_0000115>The average amplitude of the digitized acoustic startle response signal calculated across the entire duration of the defined analysis window (e.g., 200-ms window). Unit of measure: millivolts (mV) or arbitrary units.</obo:IAO_0000115>
+        <obo:IAO_0000115>The average amplitude of the digitized acoustic startle response signal calculated across the entire duration of the defined analysis window (e.g., 200-ms window). Unit: millivolts (mV) or arbitrary units.</obo:IAO_0000115>
         <rdfs:label xml:lang="en">acoustic startle response: average amplitude</rdfs:label>
     </owl:Class>
     
@@ -809,7 +812,7 @@
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000092"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the time of the total test duration in seconds&apos;). Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the time of the total test duration in seconds&apos;). Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: test duration</rdfs:label>
     </owl:Class>
     
@@ -1906,7 +1909,7 @@
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000175">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000163"/>
-        <obo:IAO_0000115>The number of seconds the individual spent freezing during a given period of time. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>The number of seconds the individual spent freezing during a given period of time. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">contextual fear conditioning: time freezing</rdfs:label>
     </owl:Class>
     
@@ -1917,7 +1920,7 @@
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000176">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000163"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000164"/>
-        <obo:IAO_0000115>In the contextual fear conditioning paradigm, this is the time of the block duration in seconds. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the contextual fear conditioning paradigm, this is the time of the block duration in seconds. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">contextual fear conditioning: block duration</rdfs:label>
     </owl:Class>
     
@@ -2456,6 +2459,284 @@
         <obo:IAO_0000115>A digital file for which the format, encoding, or origin cannot be definitively identified by the system or investigator, necessitating further manual review or specialized software for interpretation.</obo:IAO_0000115>
         <rdfs:label xml:lang="en">unknown electronic file type</rdfs:label>
     </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000231 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000231">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000101"/>
+        <obo:IAO_0000115>A parameter that specifies the technical settings, environmental conditions, or experimental design of a chemotaxis assay involving Caenorhabditis elegans.</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">C. elegans chemotaxis assay parameter</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000232 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000232">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000231"/>
+        <obo:IAO_0000115>A table containing the quantities and identities of all chemicals used as a chemoattractant (e.g., isoamyl alcohol, diacetyl) to elicit a directed movement response in C. elegans.</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">C. elegans chemotaxis assay parameter: chemoattractant mixture table</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000233 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000233">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000231"/>
+        <obo:IAO_0000115>The volume of the chemoattractant mixture pipetted onto the agar plate in a chemotaxis assay. Unit: microliters (μL).</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">C. elegans chemotaxis assay parameter: chemoattractant mixture volume</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000234 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000234">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000231"/>
+        <obo:IAO_0000115>The total time elapsed from the point at which C. elegans are placed on the assay plate until the movement is arrested or the final positions are recorded. Unit: minutes.</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">C. elegans chemotaxis assay parameter: assay duration</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000235 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000235">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000100"/>
+        <obo:IAO_0000115>A quantitative or qualitative value derived from a C. elegans chemotaxis assay, typically describing the efficiency or directionality of the animals&apos; movement toward or away from a chemical source.</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">C. elegans chemotaxis assay measurement</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000236 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000236">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000235"/>
+        <obo:IAO_0000115>A behavioral measurement of chemotactic efficiency defined as the ratio of the straight-line displacement toward the attractant to the total path length traveled by the organism. Values range from -1 to 1.</obo:IAO_0000115>
+        <oboInOwl:hasExactSynonym xml:lang="en">chemotactic ratio</oboInOwl:hasExactSynonym>
+        <rdfs:label xml:lang="en">C. elegans chemotaxis assay measurement: McCutcheon index</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000237 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000237">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000235"/>
+        <obo:IAO_0000115>The average speed of a C. elegans individual or population during the duration of the chemotaxis assay. Unit: micrometers per second (µm/s).</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">C. elegans chemotaxis assay measurement: mean velocity</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000238 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000238">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000076"/>
+        <obo:IAO_0000115>A specific genetic variant or line of an organism designated by the investigator, often containing unique mutations, transgenes, or genomic edits not yet categorized in a public repository.</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">investigator-defined strain</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000239 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000239">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000238"/>
+        <obo:IAO_0000115>A specific strain of Caenorhabditis elegans, identified by its genotype or a standard nomenclature (e.g., N2, CB4856), used in experimental procedures.</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">C. elegans strain</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000240 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000240">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000239"/>
+        <obo:IAO_0000115>A C. elegans strain with the genotype daf-22 (m130). This strain was originally obtained from the Caenorhabditis Genetics Center (CGC) as strain DR476 and subsequently outcrossed three times. [Source: https://doi.org/TBD]</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">BAB9001</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000241 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000241">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000239"/>
+        <obo:IAO_0000115>A C. elegans klp-6 rescue strain with the genotype klp-6 (my8); Pklp-6::GFP::KLP-6 (array, IndEx 9002). [Source: https://doi.org/TBD]</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">BAB9002</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000242 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000242">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000239"/>
+        <obo:IAO_0000115>A C. elegans strain with the genotype cil-7 (tm5848) I, exhibiting a him phenotype. This strain was obtained from the National BioResource Project (NBRP), Japan. [Source: https://doi.org/TBD]</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">TM5848</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000243 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000243">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000239"/>
+        <obo:IAO_0000115>A C. elegans strain with the genotype cil-7 (my61[cil-7::mNG])I; him-5(e1490) V. This strain was provided as a gift from the Maureen Barr lab. [Source: https://doi.org/TBD]</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">PT3602</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000244 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000244">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000239"/>
+        <obo:IAO_0000115>A C. elegans strain with the genotype PT3602; Pnlp-43_hCaspase nZ (array IndEx 9003). [Source: https://doi.org/TBD]</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">BAB9003</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000245 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000245">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000239"/>
+        <obo:IAO_0000115>A C. elegans strain with the genotype PT3602; Pklp-6_hCaspase Cz (array IndEx 9004). [Source: https://doi.org/TBD]</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">BAB9004</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000246 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000246">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000239"/>
+        <obo:IAO_0000115>A C. elegans strain with the genotype PT3602; Pnlp-43_hCaspase nZ (array IndEx 9003) and Pklp-6_hCaspase Cz (array IndEx 9004). [Source: https://doi.org/TBD]</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">BAB9005</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000247 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000247">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000001"/>
+        <obo:IAO_0000115>fluorescence imaging measurement</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">fluorescence imaging measurement</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000248 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000248">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000247"/>
+        <obo:IAO_0000115>Mean fluorescence intensity. Unit: arbitrary units (AU)</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">mean fluorescence intensity</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000249 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000249">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000247"/>
+        <obo:IAO_0000115>A quantitative measurement of the number of distinct fluorescent spots or puncta detected within a defined region of interest in a fluorescence image. Unit: count</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">fluorescent punctal count</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000250 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000250">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000080"/>
+        <obo:IAO_0000115>A specific parameter related to fluorescence imaging acquisition or assay.</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">fluorescence imaging parameter</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000251 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000251">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000250"/>
+        <obo:IAO_0000115>fluorescence target ontology identifier</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">fluorescence target ontology identifier</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000252 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000252">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000250"/>
+        <obo:IAO_0000115>fluorescence target name</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">fluorescence target name</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000253 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000253">
+        <obo:IAO_0000115>A .dna file format designed for storing annotated DNA sequences, including linear/circular topology, features, primers, and enzyme sites.</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">SnapGene file format</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000254 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000254">
+        <obo:IAO_0000115>A preparation of Escherichia coli strain OP50 that has been rendered non-viable through the application of heat, typically used as a non-proliferating food source in C. elegans assays.</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">Escherichia coli OP50: heat-killed</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000255 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000255">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000189"/>
+        <obo:IAO_0000115>Method used to transfer C. elegans whereby an M9 buffer is used to wash C. elegans off of an agar plate. Animals can then be transferred using a piper.</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">C. elegans transfer method: M9 buffer wash</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000256 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000256">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000189"/>
+        <obo:IAO_0000115>Method used to transfer C. elegans whereby a titanium pick is used to scoop animals off of an agar plate.</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">C. elegans transfer method: titanium pick</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000257 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000257">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000129"/>
+        <obo:IAO_0000115>A video recording capturing the behavior of C. elegans during a chemotaxis assay.</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">C. elegans chemotaxis assay: video recording</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000258 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000258">
+        <obo:IAO_0000115>An image or video acquired using fluorescence microscopy.</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">fluorescence imaging data</rdfs:label>
+    </owl:Class>
 </rdf:RDF>
 
 
diff --git a/empty.json b/empty.json
index 9aee92e..b42a39d 100644
--- a/empty.json
+++ b/empty.json
@@ -16,12 +16,12 @@
         "val" : "EMPTY by NDI is licensed under CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/). You are free to share (copy and redistribute the material in any medium or format) and adapt (remix, transform, and build upon the material) for any purpose, even commercially. You must give appropriate credit (by using the original ontology IRI for the whole ontology or original term IRIs for individual terms), provide a link to the license, and indicate if any changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use."
       }, {
         "pred" : "http://www.w3.org/2002/07/owl#versionInfo",
-        "val" : "2026-02-23"
+        "val" : "2026-04-04"
       }, {
         "pred" : "http://www.w3.org/2002/07/owl#versionInfo",
         "val" : "Release 2025-07-10"
       } ],
-      "version" : "http://purl.obolibrary.org/obo/empty/releases/2026-02-23/empty.json"
+      "version" : "http://purl.obolibrary.org/obo/empty/releases/2026-04-04/empty.json"
     },
     "nodes" : [ {
       "id" : "http://purl.obolibrary.org/obo/BFO_0000001",
@@ -129,7 +129,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "Elementary particle not affected by the strong force having a spin 1/2, a negative elementary charge and a rest mass of 0.000548579903(13) u, or 0.51099906(15) MeV."
+          "val" : "Elementary particle not affected by the strong force having a spin ½, a negative elementary charge and a rest mass of 0.000548579903(13) u, or 0.51099906(15) MeV."
         }
       }
     }, {
@@ -138,7 +138,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "Any bacterial metabolite produced during a metabolic reaction in Mycoplasma genitalium."
+          "val" : "Any bacterial metabolite produced during a metabolic reaction in <em>Mycoplasma genitalium</em>."
         }
       }
     }, {
@@ -165,7 +165,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "Any steroid that has beta-configuration at position 5."
+          "val" : "Any steroid that has β-configuration at position 5."
         }
       }
     }, {
@@ -174,7 +174,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "A Bronsted acid derived from one or more inorganic compounds. Inorganic acids (also known as mineral acids) form hydrons and conjugate base ions when dissolved in water."
+          "val" : "A Brønsted acid derived from one or more inorganic compounds. Inorganic acids (also known as mineral acids) form hydrons and conjugate base ions when dissolved in water."
         }
       }
     }, {
@@ -183,7 +183,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "Any member of a group of hydroxy steroids occuring in bile, where they are present as the sodium salts of their amides with glycine or taurine. In mammals bile acids almost invariably have 5beta-configuration, while in lower vertebrates, some bile acids, known as allo-bile acids, have 5alpha-configuration."
+          "val" : "Any member of a group of hydroxy steroids occuring in bile, where they are present as the sodium salts of their amides with glycine or taurine. In mammals bile acids almost invariably have 5β-configuration, while in lower vertebrates, some bile acids, known as <i>allo</i>-bile acids, have 5α-configuration."
         }
       }
     }, {
@@ -192,7 +192,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "Any main group molecular entity that is gaseous at standard temperature and pressure (STP; 0degreeC and 100 kPa)."
+          "val" : "Any main group molecular entity that is gaseous at standard temperature and pressure (STP; 0°C and 100 kPa)."
         }
       }
     }, {
@@ -214,7 +214,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "An antigenic epitope recognized by an anti-bilirubin monoclonal antibody designated 24G7. A substructure of bilirubin IXalpha, it is the region containing the oxo group at C-1, the methyl group at C-2, C-(4, 5, 6, 9), and N-21 and -22."
+          "val" : "An antigenic epitope recognized by an anti-bilirubin monoclonal antibody designated 24G7. A substructure of bilirubin IXα, it is the region containing the oxo group at C-1, the methyl group at C-2, C-(4, 5, 6, 9), and N-21 and -22."
         }
       }
     }, {
@@ -223,7 +223,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "An alpha-amino-acid anion that is the conjugate base of glutamic acid, having anionic carboxy groups and a cationic amino group"
+          "val" : "An α-amino-acid anion that is the conjugate base of glutamic acid, having anionic carboxy groups and a cationic amino group"
         }
       }
     }, {
@@ -253,6 +253,15 @@
           "val" : "A simple monocarboxylic acid containing two carbons."
         }
       }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/CHEBI_15378",
+      "lbl" : "hydron",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "The general name for the hydrogen nucleus, to be used without regard to the hydrogen nuclear mass (either for hydrogen in its natural abundance or where it is not desired to distinguish between the isotopes)."
+        }
+      }
     }, {
       "id" : "http://purl.obolibrary.org/obo/CHEBI_15379",
       "lbl" : "dioxygen",
@@ -263,7 +272,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "Aldehydic parent sugars (polyhydroxy aldehydes H[CH(OH)]nC(=O)H, n >= 2) and their intramolecular hemiacetals."
+          "val" : "Aldehydic parent sugars (polyhydroxy aldehydes H[CH(OH)]<small><sub><em>n</em></sub></small>C(=O)H, <em>n</em> ≥ 2) and their intramolecular hemiacetals."
         }
       }
     }, {
@@ -272,7 +281,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "Any alpha-amino acid having L-configuration at the alpha-carbon."
+          "val" : "Any α-amino acid having <small>L</small>-configuration at the α-carbon."
         }
       }
     }, {
@@ -290,7 +299,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "An optically active form of glutamic acid having D-configuration."
+          "val" : "An optically active form of glutamic acid having <small>D</small>-configuration."
         }
       }
     }, {
@@ -308,7 +317,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "An optically active form of glutamic acid having L-configuration."
+          "val" : "An optically active form of glutamic acid having <small>L</small>-configuration."
         }
       }
     }, {
@@ -368,7 +377,12 @@
     }, {
       "id" : "http://purl.obolibrary.org/obo/CHEBI_166902",
       "lbl" : "noradrenaline(1+)",
-      "type" : "CLASS"
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "An organic cation that is the conjugate acid of noradrenaline, obtained by protonation of the primary amino group; major species at pH 7.3."
+        }
+      }
     }, {
       "id" : "http://purl.obolibrary.org/obo/CHEBI_16733",
       "lbl" : "D-alpha-amino acid",
@@ -397,7 +411,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "A gamma-amino acid that is butanoic acid with the amino substituent located at C-4."
+          "val" : "A γ-amino acid that is butanoic acid with the amino substituent located at C-4."
         }
       }
     }, {
@@ -415,7 +429,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "A compound in which a carbonyl group is bonded to two carbon atoms: R2C=O (neither R may be H)."
+          "val" : "A compound in which a carbonyl group is bonded to two carbon atoms: R<small><sub>2</sub></small>C=O (neither R may be H)."
         }
       }
     }, {
@@ -460,7 +474,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "Any D-aldose having a chain of six carbon atoms in the molecule."
+          "val" : "Any <small>D</small>-aldose having a chain of six carbon atoms in the molecule."
         }
       }
     }, {
@@ -469,7 +483,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "A glucose with D-configuration."
+          "val" : "A glucose with <small>D</small>-configuration."
         }
       }
     }, {
@@ -541,7 +555,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "An alpha-amino acid that is glutaric acid bearing a single amino substituent at position 2."
+          "val" : "An α-amino acid that is glutaric acid bearing a single amino substituent at position 2."
         }
       }
     }, {
@@ -559,7 +573,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "The R-enantiomer of noradrenaline."
+          "val" : "The <i>R</i>-enantiomer of noradrenaline."
         }
       }
     }, {
@@ -616,7 +630,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "A molecular entity having an available pair of electrons capable of forming a covalent bond with a hydron (Bronsted base) or with the vacant orbital of some other molecular entity (Lewis base)."
+          "val" : "A molecular entity having an available pair of electrons capable of forming a covalent bond with a hydron (Brønsted base) or with the vacant orbital of some other molecular entity (Lewis base)."
         }
       }
     }, {
@@ -629,7 +643,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "Any compound that produces a peak used as reference frequency in the delta chemical shift scale."
+          "val" : "Any compound that produces a peak used as reference frequency in the δ chemical shift scale."
         }
       }
     }, {
@@ -672,6 +686,15 @@
           "val" : "Any constitutionally or isotopically distinct atom, molecule, ion, ion pair, radical, radical ion, complex, conformer etc., identifiable as a separately distinguishable entity."
         }
       }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/CHEBI_234420",
+      "lbl" : "(S)-noradrenaline(1+)",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "An organic cation that is the conjugate acid of (<i>S</i>)-noradrenaline, obtained by protonation of the primary amino group; major species at pH 7.3."
+        }
+      }
     }, {
       "id" : "http://purl.obolibrary.org/obo/CHEBI_23449",
       "lbl" : "cyclic peptide",
@@ -704,7 +727,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "An L-alpha-amino acid which is L-glutamic acid or any of the essential amino acids biosynthesised from it (glutamine, proline and arginine). A closed class."
+          "val" : "An <small>L</small>-α-amino acid which is <small>L</small>-glutamic acid or any of the essential amino acids biosynthesised from it (glutamine, proline and arginine). A closed class."
         }
       }
     }, {
@@ -713,7 +736,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "An EC 6.3.* (C-N bond-forming ligase) inhibitor that interferes with the action of glutamate--ammonia ligase (EC 6.3.1.2)."
+          "val" : "An EC 6.3.* (<em>C</em>‒<em>N</em> bond-forming ligase) inhibitor that interferes with the action of glutamate—ammonia ligase (EC 6.3.1.2)."
         }
       }
     }, {
@@ -789,7 +812,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "Hydroxides are chemical compounds containing a hydroxy group or salts containing hydroxide (OH(-))."
+          "val" : "Hydroxides are chemical compounds containing a hydroxy group or salts containing hydroxide (OH<small><sup>−</small></sup>)."
         }
       }
     }, {
@@ -798,7 +821,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "Any member of the class of 5beta-cholanic acids carrying at least one hydroxy group at unspecified position."
+          "val" : "Any member of the class of 5β-cholanic acids carrying at least one hydroxy group at unspecified position."
         }
       }
     }, {
@@ -903,7 +926,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "A group of neurotransmitters and neuromodulators that contain one amino group that is connected to an aromatic ring by ethylene group  (-CH2-CH2-). Monoamines are derived from the aromatic amino acids phenylalanine, tyrosine, histidine and tryptophan."
+          "val" : "A group of neurotransmitters and neuromodulators that contain one amino group that is connected to an aromatic ring by ethylene group  (‒CH<small><sub>2</sub></small>‒CH<small><sub>2</sub></small>‒). Monoamines are derived from the aromatic amino acids phenylalanine, tyrosine, histidine and tryptophan."
         }
       }
     }, {
@@ -1017,7 +1040,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "An aliphatic monocarboxylic acid with a chain length of less than C6. If any non-hydrocarbon substituent is present, the compound is not normally regarded as a short-chain fatty acid."
+          "val" : "An aliphatic monocarboxylic acid with a chain length of less than C<small><sub>6</sub></small>. If any non-hydrocarbon substituent is present, the compound is not normally regarded as a short-chain fatty acid."
         }
       }
     }, {
@@ -1140,7 +1163,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "A polydisperse, highly branched glucan composed of chains of D-glucopyranose residues in alpha(1->4) glycosidic linkage, joined together by alpha(1->6) glycosidic linkages. A small number of alpha(1->3) glycosidic linkages and some cumulative alpha(1->6) links also may occur. The branches in glycogen typically contain 8 to 12 glucose residues."
+          "val" : "A polydisperse, highly branched glucan composed of chains of <small>D</small>-glucopyranose residues in α(1→4) glycosidic linkage, joined together by α(1→6) glycosidic linkages. A small number of α(1→3) glycosidic linkages and some cumulative α(1→6) links also may occur. The branches in glycogen typically contain 8 to 12 glucose residues."
         }
       }
     }, {
@@ -1233,7 +1256,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "An alpha-amino-acid anion that is the conjugate base of L-glutamic acid, having anionic carboxy groups and a cationic amino group"
+          "val" : "An α-amino-acid anion that is the conjugate base of <small>L</small>-glutamic acid, having anionic carboxy groups and a cationic amino group"
         }
       }
     }, {
@@ -1242,7 +1265,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "An alpha-amino-acid anion that is the conjugate base of D-glutamic acid, having anionic carboxy groups and a cationic amino group"
+          "val" : "An α-amino-acid anion that is the conjugate base of <small>D</small>-glutamic acid, having anionic carboxy groups and a cationic amino group"
         }
       }
     }, {
@@ -1251,7 +1274,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "A dicarboxylic acid dianion that is the conjugate base of glutamate(1-)."
+          "val" : "A dicarboxylic acid dianion that is the conjugate base of glutamate(1−)."
         }
       }
     }, {
@@ -1260,7 +1283,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "An L-alpha-amino acid anion that is the dianion obtained by the deprotonation of the both the carboxy groups of L-glutamic acid."
+          "val" : "An <small>L</small>-α-amino acid anion that is the dianion obtained by the deprotonation of the both the carboxy groups of <small>L</small>-glutamic acid."
         }
       }
     }, {
@@ -1291,7 +1314,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "An gamma-amino acid anion resulting from the deprotonation of the carboxy group of gamma-aminobutyric acid."
+          "val" : "An γ-amino acid anion resulting from the deprotonation of the carboxy group of γ-aminobutyric acid."
         }
       }
     }, {
@@ -1309,7 +1332,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "Any member of a group of hydroxy-5beta-cholanic acids occuring in bile, where they are present as the sodium salts of their amides with glycine or taurine. In mammals bile acids almost invariably have 5beta-configuration."
+          "val" : "Any member of a group of hydroxy-5β-cholanic acids occuring in bile, where they are present as the sodium salts of their amides with glycine or taurine. In mammals bile acids almost invariably have 5β-configuration."
         }
       }
     }, {
@@ -1410,6 +1433,10 @@
           "val" : "A chemical entity constituting the smallest component of an element having the chemical properties of the element."
         }
       }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/CHEBI_33251",
+      "lbl" : "monoatomic hydrogen",
+      "type" : "CLASS"
     }, {
       "id" : "http://purl.obolibrary.org/obo/CHEBI_33252",
       "lbl" : "atomic nucleus",
@@ -1446,6 +1473,10 @@
           "val" : "A molecular entity all atoms of which have the same atomic number."
         }
       }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/CHEBI_33260",
+      "lbl" : "elemental hydrogen",
+      "type" : "CLASS"
     }, {
       "id" : "http://purl.obolibrary.org/obo/CHEBI_33262",
       "lbl" : "elemental oxygen",
@@ -1549,7 +1580,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "An ester of a carboxylic acid, R(1)C(=O)OR(2), where R(1) = H or organyl and R(2) = organyl."
+          "val" : "An ester of a carboxylic acid, R<small><sup>1</small></sup>C(=O)OR<small><sup>2</small></sup>, where R<small><sup>1</small></sup> = H or organyl and R<small><sup>2</small></sup> = organyl."
         }
       }
     }, {
@@ -1600,7 +1631,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "An amino-acid anion obtained by deprotonation of any alpha-amino acid."
+          "val" : "An amino-acid anion obtained by deprotonation of any α-amino acid."
         }
       }
     }, {
@@ -1622,7 +1653,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "Any compound containing an o-diphenol component."
+          "val" : "Any compound containing an <em>o</em>-diphenol component."
         }
       }
     }, {
@@ -1653,7 +1684,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "The S-enantiomer of noradrenaline."
+          "val" : "The <i>S</i>-enantiomer of noradrenaline."
         }
       }
     }, {
@@ -1662,7 +1693,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "A carbon oxoacid acid carrying at least one -C(=O)OH group and having the structure RC(=O)OH, where R is any any monovalent functional group. Carboxylic acids are the most common type of organic acid."
+          "val" : "A carbon oxoacid acid carrying at least one ‒C(=O)OH group and having the structure RC(=O)OH, where R is any any monovalent functional group. Carboxylic acids are the most common type of organic acid."
         }
       }
     }, {
@@ -1710,7 +1741,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "A cyclically conjugated molecular entity with a stability (due to delocalization) significantly greater than that of a hypothetical localized structure (e.g. Kekule structure) is said to possess aromatic character."
+          "val" : "A cyclically conjugated molecular entity with a stability (due to delocalization) significantly greater than that of a hypothetical localized structure (e.g. Kekulé structure) is said to possess aromatic character."
         }
       }
     }, {
@@ -1820,7 +1851,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "An amino acid in which the amino group is located on the carbon atom at the position alpha to the carboxy group."
+          "val" : "An amino acid in which the amino group is located on the carbon atom at the position α to the carboxy group."
         }
       }
     }, {
@@ -1829,7 +1860,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "A non-proteinogenic amino-acid in which the amino group is located on the carbon atom at the position gamma to the carboxy group."
+          "val" : "A non-proteinogenic amino-acid in which the amino group is located on the carbon atom at the position γ to the carboxy group."
         }
       }
     }, {
@@ -1856,7 +1887,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "An amino-acid residue derived from an alpha-amino acid."
+          "val" : "An amino-acid residue derived from an α-amino acid."
         }
       }
     }, {
@@ -1903,7 +1934,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "A heterocyclic compound formally derived from an arene by replacement of one or more methine (-C=) and/or vinylene (-CH=CH-) groups by trivalent or divalent heteroatoms, respectively, in such a way as to maintain the continuous pi-electron system characteristic of aromatic systems and a number of out-of-plane pi-electrons corresponding to the Hueckel rule (4n+2)."
+          "val" : "A heterocyclic compound formally derived from an arene by replacement of one or more methine (‒C=) and/or vinylene (‒CH=CH‒) groups by trivalent or divalent heteroatoms, respectively, in such a way as to maintain the continuous π-electron system characteristic of aromatic systems and a number of out-of-plane π-electrons corresponding to the Hückel rule (4<em>n</em>+2)."
         }
       }
     }, {
@@ -2019,7 +2050,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "A derivative of ammonium, NH4(+), in which all four of the hydrogens bonded to nitrogen have been replaced with univalent (usually organyl) groups."
+          "val" : "A derivative of ammonium, NH<small><sub>4</sub></small><small><sup>+</small></sup>, in which all four of the hydrogens bonded to nitrogen have been replaced with univalent (usually organyl) groups."
         }
       }
     }, {
@@ -2028,7 +2059,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "A derivative of ammonium, NH4(+), in which one (or more) of the hydrogens bonded to the nitrogen have been replaced with univalent organyl groups. The substituting carbon of the organyl group must not itself be directly attached to a heteroatom (thereby excluding protonated amides, hemiaminals, etc)."
+          "val" : "A derivative of ammonium, NH<small><sub>4</sub></small><small><sup>+</small></sup>, in which one (or more) of the hydrogens bonded to the nitrogen have been replaced with univalent organyl groups. The substituting carbon of the organyl group must not itself be directly attached to a heteroatom (thereby excluding protonated amides, hemiaminals, etc)."
         }
       }
     }, {
@@ -2077,7 +2108,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "Parent monosaccharides are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H-[CHOH]n-C(=O)[CHOH]m-H with three or more carbon atoms. The generic term 'monosaccharide' (as opposed to oligosaccharide or polysaccharide) denotes a single unit, without glycosidic connection to other such units. It includes aldoses, dialdoses, aldoketoses, ketoses and diketoses, as well as deoxy sugars, provided that the parent compound has a (potential) carbonyl group."
+          "val" : "Parent monosaccharides are polyhydroxy aldehydes H[CH(OH)]<small><sub><em>n</em></sub></small>C(=O)H or polyhydroxy ketones H‒[CHOH]<small><sub><em>n</em></sub></small>‒C(=O)[CHOH]<small><sub><em>m</em></sub></small>‒H with three or more carbon atoms. The generic term 'monosaccharide' (as opposed to oligosaccharide or polysaccharide) denotes a single unit, without glycosidic connection to other such units. It includes aldoses, dialdoses, aldoketoses, ketoses and diketoses, as well as deoxy sugars, provided that the parent compound has a (potential) carbonyl group."
         }
       }
     }, {
@@ -2138,7 +2169,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "An agent that selectively binds to and activates alpha-adrenergic receptors."
+          "val" : "An agent that selectively binds to and activates α-adrenergic receptors."
         }
       }
     }, {
@@ -2147,7 +2178,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "A negative ion consisting solely of carbon and oxygen  atoms, and therefore having the general formula CxOy(n-) for some integers x, y and n."
+          "val" : "A negative ion consisting solely of carbon and oxygen  atoms, and therefore having the general formula C<small><sub><em>x</em></sub></small>O<small><sub><em>y</em></sub></small><small><sup><em>n</em>−</small></sup> for some integers <em>x</em>, <em>y</em> and <em>n</em>."
         }
       }
     }, {
@@ -2251,7 +2282,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "Members of the class of cholanic acids based on a 5beta-cholane skeleton."
+          "val" : "Members of the class of cholanic acids based on a 5β-cholane skeleton."
         }
       }
     }, {
@@ -2273,7 +2304,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "Lepton is a fermion that does not experience the strong force (strong interaction). The term is derived from the Greek lambdaepsilonpitauomicronsigma (small, thin)."
+          "val" : "Lepton is a fermion that does not experience the strong force (strong interaction). The term is derived from the Greek λεπτοσ (small, thin)."
         }
       }
     }, {
@@ -2282,7 +2313,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "Baryon is a fermion that does experience the strong force (strong interaction). The term is derived from the Greek betaalpharhoupsilonsigma (heavy)."
+          "val" : "Baryon is a fermion that does experience the strong force (strong interaction). The term is derived from the Greek βαρυσ (heavy)."
         }
       }
     }, {
@@ -2476,7 +2507,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "An acid is a molecular entity capable of donating a hydron (Bronsted acid) or capable of forming a covalent bond with an electron pair (Lewis acid)."
+          "val" : "An acid is a molecular entity capable of donating a hydron (Brønsted acid) or capable of forming a covalent bond with an electron pair (Lewis acid)."
         }
       }
     }, {
@@ -2494,7 +2525,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "An amide of a carboxylic acid, having the structure RC(=O)NR2. The term is used as a suffix in systematic name formation to denote the -C(=O)NH2 group including its carbon atom."
+          "val" : "An amide of a carboxylic acid, having the structure RC(=O)NR<small><sub>2</sub></small>. The term is used as a suffix in systematic name formation to denote the ‒C(=O)NH<small><sub>2</sub></small> group including its carbon atom."
         }
       }
     }, {
@@ -2617,7 +2648,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "A molecular entity capable of donating a hydron to an acceptor (Bronsted base)."
+          "val" : "A molecular entity capable of donating a hydron to an acceptor (Brønsted base)."
         }
       }
     }, {
@@ -2626,7 +2657,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "A molecular entity capable of accepting a hydron from a donor (Bronsted acid)."
+          "val" : "A molecular entity capable of accepting a hydron from a donor (Brønsted acid)."
         }
       }
     }, {
@@ -2657,7 +2688,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "A glucopyranose having D-configuration."
+          "val" : "A glucopyranose having <small>D</small>-configuration."
         }
       }
     }, {
@@ -2666,7 +2697,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "A hexose that has D-configuration at position 5."
+          "val" : "A hexose that has <small>D</small>-configuration at position 5."
         }
       }
     }, {
@@ -2740,7 +2771,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "Any drug that acts on an alpha-adrenergic receptor."
+          "val" : "Any drug that acts on an α-adrenergic receptor."
         }
       }
     }, {
@@ -2943,7 +2974,12 @@
     }, {
       "id" : "http://purl.obolibrary.org/obo/CHEBI_52211",
       "lbl" : "physiological role",
-      "type" : "CLASS"
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "A biological role relating to the normal mechanisms and their interactions within a living system."
+        }
+      }
     }, {
       "id" : "http://purl.obolibrary.org/obo/CHEBI_52217",
       "lbl" : "pharmaceutical",
@@ -3040,7 +3076,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "Any fatty acid anion obtained by removal of a proton from the carboxy group of a short-chain fatty acid (chain length of less than C6)."
+          "val" : "Any fatty acid anion obtained by removal of a proton from the carboxy group of a short-chain fatty acid (chain length of less than C<small><sub>6</sub></small>)."
         }
       }
     }, {
@@ -3049,7 +3085,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "Any fatty acid anion in which there is no C-C unsaturation."
+          "val" : "Any fatty acid anion in which there is no C‒C unsaturation."
         }
       }
     }, {
@@ -3067,7 +3103,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "An organic anion of general formula RS(=O)2O(-) where R is an organyl group."
+          "val" : "An organic anion of general formula RS(=O)2O(−) where R is an organyl group."
         }
       }
     }, {
@@ -3112,7 +3148,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "Conjugate base of an L-alpha-amino acid arising from deprotonation of the C-1 carboxy group."
+          "val" : "Conjugate base of an <small>L</small>-α-amino acid arising from deprotonation of the C-1 carboxy group."
         }
       }
     }, {
@@ -3121,7 +3157,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "Zwitterionic form of an L-alpha-amino acid having an anionic carboxy group and a protonated amino group."
+          "val" : "Zwitterionic form of an <small>L</small>-α-amino acid having an anionic carboxy group and a protonated amino group."
         }
       }
     }, {
@@ -3130,7 +3166,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "Zwitterionic form of a D-alpha-amino acid having an anionic carboxy group and a protonated amino group."
+          "val" : "Zwitterionic form of a <small>D</small>-α-amino acid having an anionic carboxy group and a protonated amino group."
         }
       }
     }, {
@@ -3139,7 +3175,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "Zwitterionic form of gamma-aminobutyric acid having an anionic carboxy group and a protonated amino group."
+          "val" : "Zwitterionic form of γ-aminobutyric acid having an anionic carboxy group and a protonated amino group."
         }
       }
     }, {
@@ -3202,7 +3238,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "Any alpha-amino acid anion in which the parent amino acid has D-configuration."
+          "val" : "Any α-amino acid anion in which the parent amino acid has <small>D</small>-configuration."
         }
       }
     }, {
@@ -3337,7 +3373,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "An organic molecular entity containing a single carbon atom (C1)."
+          "val" : "An organic molecular entity containing a single carbon atom (C<small><sub>1</sub></small>)."
         }
       }
     }, {
@@ -3454,7 +3490,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "An amino-acid anion in which the amino group is situated gamma- to the carboxylate group."
+          "val" : "An amino-acid anion in which the amino group is situated γ- to the carboxylate group."
         }
       }
     }, {
@@ -3463,7 +3499,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "An organic cation that is the conjugate acid of (R)-noradrenaline, obtained by protonation of the priamry amino group; major species at pH 7.3."
+          "val" : "An organic cation that is the conjugate acid of (<i>R</i>)-noradrenaline, obtained by protonation of the primary amino group; major species at pH 7.3."
         }
       }
     }, {
@@ -3508,7 +3544,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "A ligase inhibitor that interferes with the action of a C-N bond-forming ligase (EC 6.3.*.*)."
+          "val" : "A ligase inhibitor that interferes with the action of a <em>C</em>‒<em>N</em> bond-forming ligase (EC 6.3.*.*)."
         }
       }
     }, {
@@ -3616,7 +3652,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "An EC 6.3.* (C-N bond-forming ligase) inhibitor that interferes with the action of any acid-ammonia (or amine) ligase (EC 6.3.1.*)."
+          "val" : "An EC 6.3.* (<em>C</em>‒<em>N</em> bond-forming ligase) inhibitor that interferes with the action of any acid-ammonia (or amine) ligase (EC 6.3.1.*)."
         }
       }
     }, {
@@ -3724,7 +3760,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "An amino acid-zwitterion obtained by transfer of a proton from the carboxy to the amino group of any alpha-amino acid; major species at pH 7.3."
+          "val" : "An amino acid-zwitterion obtained by transfer of a proton from the carboxy to the amino group of any α-amino acid; major species at pH 7.3."
         }
       }
     }, {
@@ -3796,7 +3832,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "Any of the 23 alpha-amino acids that are precursors to proteins, and are incorporated into proteins during translation. The group includes the 20 amino acids encoded by the nuclear genes of eukaryotes together with selenocysteine, pyrrolysine, and N-formylmethionine. Apart from glycine, which is non-chiral, all have L configuration."
+          "val" : "Any of the 23 α-amino acids that are precursors to proteins, and are incorporated into proteins during translation. The group includes the 20 amino acids encoded by the nuclear genes of eukaryotes together with selenocysteine, pyrrolysine, and <em>N</em>-formylmethionine. Apart from glycine, which is non-chiral, all have <small>L</small> configuration."
         }
       }
     }, {
@@ -3814,7 +3850,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "Any  alpha-amino acid which is not a member of the group of 23 proteinogenic amino acids."
+          "val" : "Any  α-amino acid which is not a member of the group of 23 proteinogenic amino acids."
         }
       }
     }, {
@@ -7724,7 +7760,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's body (typically defined by its center point or a significant portion) fully enters the user-defined zone designated as 'Open Arm (North)'. The 'Open Arm (North)' is one of the two open arms, distinguished by its assigned 'north' orientation or designation in the experimental setup. Unit of measure: count"
+          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's body (typically defined by its center point or a significant portion) fully enters the user-defined zone designated as 'Open Arm (North)'. The 'Open Arm (North)' is one of the two open arms, distinguished by its assigned 'north' orientation or designation in the experimental setup. Unit: count"
         }
       }
     }, {
@@ -7733,7 +7769,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's body (typically defined by its center point or a significant portion) fully enters the user-defined zone designated as 'Open Arm (South)'. The 'Open Arm (South)' is one of the two open arms, distinguished by its assigned 'south' orientation or designation in the experimental setup. Unit of measure: count"
+          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's body (typically defined by its center point or a significant portion) fully enters the user-defined zone designated as 'Open Arm (South)'. The 'Open Arm (South)' is one of the two open arms, distinguished by its assigned 'south' orientation or designation in the experimental setup. Unit: count"
         }
       }
     }, {
@@ -7742,7 +7778,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this represents the total number of times the animal's body (typically defined by its center point or a significant portion) fully enters the designated open arm zones (e.g., 'Open Arm (North)' and 'Open Arm (South)'). It is a common measure of exploration and anxiety. Unit of measure: count"
+          "val" : "In the Elevated Plus Maze task, this represents the total number of times the animal's body (typically defined by its center point or a significant portion) fully enters the designated open arm zones (e.g., 'Open Arm (North)' and 'Open Arm (South)'). It is a common measure of exploration and anxiety. Unit: count"
         }
       }
     }, {
@@ -7751,7 +7787,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's head (specifically tracked by the software) enters the user-defined 'Open Arm (North)' zone, irrespective of full body entry. This can indicate risk assessment or tentative exploration of the arm designated as 'north'. Unit of measure: count"
+          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's head (specifically tracked by the software) enters the user-defined 'Open Arm (North)' zone, irrespective of full body entry. This can indicate risk assessment or tentative exploration of the arm designated as 'north'. Unit: count"
         }
       }
     }, {
@@ -7760,7 +7796,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's head (specifically tracked by the software) enters the user-defined 'Open Arm (South)' zone, irrespective of full body entry, often reflecting cautious exploration of the open arm designated as 'south'. Unit of measure: count"
+          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's head (specifically tracked by the software) enters the user-defined 'Open Arm (South)' zone, irrespective of full body entry, often reflecting cautious exploration of the open arm designated as 'south'. Unit: count"
         }
       }
     }, {
@@ -7769,7 +7805,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this is the total number of times the animal's head (specifically tracked by the software) enters any of the designated open arm zones (e.g., 'Open Arm (North)' and 'Open Arm (South)'), considered an indicator of risk-assessment behavior. Unit of measure: count"
+          "val" : "In the Elevated Plus Maze task, this is the total number of times the animal's head (specifically tracked by the software) enters any of the designated open arm zones (e.g., 'Open Arm (North)' and 'Open Arm (South)'), considered an indicator of risk-assessment behavior. Unit: count"
         }
       }
     }, {
@@ -7778,7 +7814,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Open Arm (North)' zone. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Open Arm (North)' zone. Unit: seconds"
         }
       }
     }, {
@@ -7787,7 +7823,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Open Arm (South)' zone. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Open Arm (South)' zone. Unit: seconds"
         }
       }
     }, {
@@ -7796,7 +7832,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this is the cumulative total duration the animal's body spends within any of the designated open arm zones (e.g., 'Open Arm (North)' and 'Open Arm (South)'). Less time is generally indicative of higher anxiety. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this is the cumulative total duration the animal's body spends within any of the designated open arm zones (e.g., 'Open Arm (North)' and 'Open Arm (South)'). Less time is generally indicative of higher anxiety. Unit: seconds"
         }
       }
     }, {
@@ -7805,7 +7841,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this represents the percentage of the total test duration that the animal spends in any of the designated open arm zones (e.g., 'Open Arm (North)' and 'Open Arm (South)'). Unit of measure: %"
+          "val" : "In the Elevated Plus Maze task, this represents the percentage of the total test duration that the animal spends in any of the designated open arm zones (e.g., 'Open Arm (North)' and 'Open Arm (South)'). Unit: %"
         }
       }
     }, {
@@ -7814,7 +7850,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Open Arm (North)' zone. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Open Arm (North)' zone. Unit: seconds"
         }
       }
     }, {
@@ -7823,7 +7859,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Open Arm (South)' zone. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Open Arm (South)' zone. Unit: seconds"
         }
       }
     }, {
@@ -7832,7 +7868,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into any of the designated open arm zones (e.g., 'Open Arm (North)' or 'Open Arm (South)'). Longer latencies often suggest higher anxiety. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into any of the designated open arm zones (e.g., 'Open Arm (North)' or 'Open Arm (South)'). Longer latencies often suggest higher anxiety. Unit: seconds"
         }
       }
     }, {
@@ -7841,7 +7877,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Open Arm (North)' zone, as detected by the tracking software. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Open Arm (North)' zone, as detected by the tracking software. Unit: seconds"
         }
       }
     }, {
@@ -7850,7 +7886,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Open Arm (South)' zone, as detected by the tracking software. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Open Arm (South)' zone, as detected by the tracking software. Unit: seconds"
         }
       }
     }, {
@@ -7859,7 +7895,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this is the cumulative duration the animal spends actively moving towards any of the designated open arm zones (e.g., 'Open Arm (North)' or 'Open Arm (South)'), reflecting approach motivation. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this is the cumulative duration the animal spends actively moving towards any of the designated open arm zones (e.g., 'Open Arm (North)' or 'Open Arm (South)'), reflecting approach motivation. Unit: seconds"
         }
       }
     }, {
@@ -7868,7 +7904,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior (a state of immobility except for respiratory movements) while within the user-defined 'Open Arm (North)' zone. Freezing is a common fear response. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior (a state of immobility except for respiratory movements) while within the user-defined 'Open Arm (North)' zone. Freezing is a common fear response. Unit: seconds"
         }
       }
     }, {
@@ -7877,7 +7913,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined 'Open Arm (South)' zone. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined 'Open Arm (South)' zone. Unit: seconds"
         }
       }
     }, {
@@ -7886,7 +7922,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this is the cumulative duration the animal exhibits freezing behavior while within any of the designated open arm zones (e.g., 'Open Arm (North)' or 'Open Arm (South)'), indicating fear or anxiety. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this is the cumulative duration the animal exhibits freezing behavior while within any of the designated open arm zones (e.g., 'Open Arm (North)' or 'Open Arm (South)'), indicating fear or anxiety. Unit: seconds"
         }
       }
     }, {
@@ -7895,7 +7931,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's body fully enters the user-defined 'Closed Arm (West)' zone, representing the enclosed arm designated as 'west'. Unit of measure: count"
+          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's body fully enters the user-defined 'Closed Arm (West)' zone, representing the enclosed arm designated as 'west'. Unit: count"
         }
       }
     }, {
@@ -7904,7 +7940,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's body fully enters the user-defined 'Closed Arm (East)' zone, representing the enclosed arm designated as 'east'. Unit of measure: count"
+          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's body fully enters the user-defined 'Closed Arm (East)' zone, representing the enclosed arm designated as 'east'. Unit: count"
         }
       }
     }, {
@@ -7913,7 +7949,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this is the total number of times the animal's body fully enters any of the designated closed arm zones (e.g., 'Closed Arm (West)' and 'Closed Arm (East)'). It is often used as an indicator of general locomotor activity. Unit of measure: count"
+          "val" : "In the Elevated Plus Maze task, this is the total number of times the animal's body fully enters any of the designated closed arm zones (e.g., 'Closed Arm (West)' and 'Closed Arm (East)'). It is often used as an indicator of general locomotor activity. Unit: count"
         }
       }
     }, {
@@ -7922,7 +7958,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's head enters the user-defined 'Closed Arm (West)' zone. Unit of measure: count"
+          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's head enters the user-defined 'Closed Arm (West)' zone. Unit: count"
         }
       }
     }, {
@@ -7931,7 +7967,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's head enters the user-defined 'Closed Arm (East)' zone. Unit of measure: count"
+          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's head enters the user-defined 'Closed Arm (East)' zone. Unit: count"
         }
       }
     }, {
@@ -7940,7 +7976,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this is the total number of times the animal's head enters any of the designated closed arm zones (e.g., 'Closed Arm (West)' and 'Closed Arm (East)'). Unit of measure: count"
+          "val" : "In the Elevated Plus Maze task, this is the total number of times the animal's head enters any of the designated closed arm zones (e.g., 'Closed Arm (West)' and 'Closed Arm (East)'). Unit: count"
         }
       }
     }, {
@@ -7949,7 +7985,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Closed Arm (West)' zone. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Closed Arm (West)' zone. Unit: seconds"
         }
       }
     }, {
@@ -7958,7 +7994,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Closed Arm (East)' zone. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Closed Arm (East)' zone. Unit: seconds"
         }
       }
     }, {
@@ -7967,7 +8003,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this is the cumulative total duration the animal's body spends within any of the designated closed arm zones (e.g., 'Closed Arm (West)' and 'Closed Arm (East)'). Animals typically spend more time in these 'safer' areas. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this is the cumulative total duration the animal's body spends within any of the designated closed arm zones (e.g., 'Closed Arm (West)' and 'Closed Arm (East)'). Animals typically spend more time in these 'safer' areas. Unit: seconds"
         }
       }
     }, {
@@ -7976,7 +8012,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this represents the percentage of the total test duration that the animal spends in any of the designated closed arm zones (e.g., 'Closed Arm (West)' and 'Closed Arm (East)'). Unit of measure: %"
+          "val" : "In the Elevated Plus Maze task, this represents the percentage of the total test duration that the animal spends in any of the designated closed arm zones (e.g., 'Closed Arm (West)' and 'Closed Arm (East)'). Unit: %"
         }
       }
     }, {
@@ -7985,7 +8021,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Closed Arm (West)' zone. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Closed Arm (West)' zone. Unit: seconds"
         }
       }
     }, {
@@ -7994,7 +8030,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Closed Arm (East)' zone. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Closed Arm (East)' zone. Unit: seconds"
         }
       }
     }, {
@@ -8003,7 +8039,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into any of the designated closed arm zones (e.g., 'Closed Arm (West)' or 'Closed Arm (East)'). Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into any of the designated closed arm zones (e.g., 'Closed Arm (West)' or 'Closed Arm (East)'). Unit: seconds"
         }
       }
     }, {
@@ -8012,7 +8048,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Closed Arm (West)' zone. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Closed Arm (West)' zone. Unit: seconds"
         }
       }
     }, {
@@ -8021,7 +8057,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Closed Arm (East)' zone. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Closed Arm (East)' zone. Unit: seconds"
         }
       }
     }, {
@@ -8030,7 +8066,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this is the cumulative duration the animal spends actively moving towards any of the designated closed arm zones (e.g., 'Closed Arm (West)' or 'Closed Arm (East)'). Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this is the cumulative duration the animal spends actively moving towards any of the designated closed arm zones (e.g., 'Closed Arm (West)' or 'Closed Arm (East)'). Unit: seconds"
         }
       }
     }, {
@@ -8039,7 +8075,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined 'Closed Arm (West)' zone. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined 'Closed Arm (West)' zone. Unit: seconds"
         }
       }
     }, {
@@ -8048,7 +8084,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined 'Closed Arm (East)' zone. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined 'Closed Arm (East)' zone. Unit: seconds"
         }
       }
     }, {
@@ -8057,7 +8093,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this is the cumulative duration the animal exhibits freezing behavior while within any of the designated closed arm zones (e.g., 'Closed Arm (West)' or 'Closed Arm (East)'). Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this is the cumulative duration the animal exhibits freezing behavior while within any of the designated closed arm zones (e.g., 'Closed Arm (West)' or 'Closed Arm (East)'). Unit: seconds"
         }
       }
     }, {
@@ -8066,7 +8102,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's body fully enters the user-defined 'Center' zone of the maze, typically from one of the arms. The center zone is the area where all four arms meet. Unit of measure: count"
+          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's body fully enters the user-defined 'Center' zone of the maze, typically from one of the arms. The center zone is the area where all four arms meet. Unit: count"
         }
       }
     }, {
@@ -8075,7 +8111,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's head enters the user-defined 'Center' zone of the maze. Unit of measure: count"
+          "val" : "In the Elevated Plus Maze task, this counts the number of times the animal's head enters the user-defined 'Center' zone of the maze. Unit: count"
         }
       }
     }, {
@@ -8084,7 +8120,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Center' zone. Time in the center can indicate decision-making or risk assessment. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Center' zone. Time in the center can indicate decision-making or risk assessment. Unit: seconds"
         }
       }
     }, {
@@ -8093,7 +8129,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this represents the percentage of the total test duration that the animal spends in the user-defined 'Center' zone of the maze. Unit of measure: %"
+          "val" : "In the Elevated Plus Maze task, this represents the percentage of the total test duration that the animal spends in the user-defined 'Center' zone of the maze. Unit: %"
         }
       }
     }, {
@@ -8102,7 +8138,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Center' zone. If the animal starts in the center, this value may be zero or not applicable. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Center' zone. If the animal starts in the center, this value may be zero or not applicable. Unit: seconds"
         }
       }
     }, {
@@ -8111,7 +8147,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Center' zone of the maze (e.g., from an arm). Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Center' zone of the maze (e.g., from an arm). Unit: seconds"
         }
       }
     }, {
@@ -8120,7 +8156,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined 'Center' zone of the maze. Freezing in this relatively exposed area can indicate high anxiety. Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined 'Center' zone of the maze. Freezing in this relatively exposed area can indicate high anxiety. Unit: seconds"
         }
       }
     }, {
@@ -8147,7 +8183,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Fear-potentiated startle paradigm, this is the amplitude of the acoustic startle response (ASR) measured in response to a startle-eliciting stimulus (e.g., 95-dB white noise burst) prior to any fear conditioning procedures, typically assessed during habituation or pre-conditioning phase. This measurement serves as a reference point for later comparisons with post-conditioning startle responses. Unit of measure: arbitrary units or standardized score."
+          "val" : "In the Fear-potentiated startle paradigm, this is the amplitude of the acoustic startle response (ASR) measured in response to a startle-eliciting stimulus (e.g., 95-dB white noise burst) prior to any fear conditioning procedures, typically assessed during habituation or pre-conditioning phase. This measurement serves as a reference point for later comparisons with post-conditioning startle responses. Unit: arbitrary units or standardized score."
         }
       }
     }, {
@@ -8192,7 +8228,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "Identifier for the specific Plexiglas enclosure or sound-attenuating chamber within the Fear-Potentiated Startle (FPS) apparatus (e.g., San Diego Instruments SR-Lab) in which a subject was tested for a given trial. Unit of measure: count or identifier string"
+          "val" : "Identifier for the specific Plexiglas enclosure or sound-attenuating chamber within the Fear-Potentiated Startle (FPS) apparatus (e.g., San Diego Instruments SR-Lab) in which a subject was tested for a given trial. Unit: count or identifier string"
         }
       }
     }, {
@@ -8210,7 +8246,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "The total number of data points (samples) recorded and analyzed for a single acoustic startle response, typically within a defined time window following stimulus onset (e.g., a 200-ms window as mentioned in the manuscript). Unit of measure: count"
+          "val" : "The total number of data points (samples) recorded and analyzed for a single acoustic startle response, typically within a defined time window following stimulus onset (e.g., a 200-ms window as mentioned in the manuscript). Unit: count"
         }
       }
     }, {
@@ -8219,7 +8255,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "The rate at which the analog startle response signal was digitized during data acquisition. Unit of measure: Hertz (Hz)"
+          "val" : "The rate at which the analog startle response signal was digitized during data acquisition. Unit: Hertz (Hz)"
         }
       }
     }, {
@@ -8228,7 +8264,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "The amplitude of the digitized acoustic startle response signal at the very beginning (onset) of the defined analysis window (e.g., a 200-ms window) used to quantify the reflex. Unit of measure: millivolts (mV) or arbitrary units based on transducer calibration."
+          "val" : "The amplitude of the digitized acoustic startle response signal at the very beginning (onset) of the defined analysis window (e.g., a 200-ms window) used to quantify the reflex. Unit: millivolts (mV) or arbitrary units based on transducer calibration."
         }
       }
     }, {
@@ -8237,7 +8273,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "The peak amplitude of the acoustic startle response (e.g., 'jump amplitude') detected within the defined analysis window (e.g., 200-ms window) for a given trial. Unit of measure: millivolts (mV) or arbitrary units."
+          "val" : "The peak amplitude of the acoustic startle response (e.g., 'jump amplitude') detected within the defined analysis window (e.g., 200-ms window) for a given trial. Unit: millivolts (mV) or arbitrary units."
         }
       }
     }, {
@@ -8246,7 +8282,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "The latency from the onset of the startle-eliciting stimulus (or the beginning of the analysis window) to the occurrence of the maximum (peak) amplitude of the acoustic startle response. Unit of measure: milliseconds (ms)"
+          "val" : "The latency from the onset of the startle-eliciting stimulus (or the beginning of the analysis window) to the occurrence of the maximum (peak) amplitude of the acoustic startle response. Unit: milliseconds (ms)"
         }
       }
     }, {
@@ -8255,7 +8291,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "The average amplitude of the digitized acoustic startle response signal calculated across the entire duration of the defined analysis window (e.g., 200-ms window). Unit of measure: millivolts (mV) or arbitrary units."
+          "val" : "The average amplitude of the digitized acoustic startle response signal calculated across the entire duration of the defined analysis window (e.g., 200-ms window). Unit: millivolts (mV) or arbitrary units."
         }
       }
     }, {
@@ -8282,7 +8318,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the Elevated Plus Maze task, this is the time of the total test duration in seconds'). Unit of measure: seconds"
+          "val" : "In the Elevated Plus Maze task, this is the time of the total test duration in seconds'). Unit: seconds"
         }
       }
     }, {
@@ -9259,7 +9295,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "The number of seconds the individual spent freezing during a given period of time. Unit of measure: seconds"
+          "val" : "The number of seconds the individual spent freezing during a given period of time. Unit: seconds"
         }
       }
     }, {
@@ -9268,7 +9304,7 @@
       "type" : "CLASS",
       "meta" : {
         "definition" : {
-          "val" : "In the contextual fear conditioning paradigm, this is the time of the block duration in seconds. Unit of measure: seconds"
+          "val" : "In the contextual fear conditioning paradigm, this is the time of the block duration in seconds. Unit: seconds"
         }
       }
     }, {
@@ -9746,6 +9782,262 @@
           "val" : "A digital file for which the format, encoding, or origin cannot be definitively identified by the system or investigator, necessitating further manual review or specialized software for interpretation."
         }
       }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000231",
+      "lbl" : "C. elegans chemotaxis assay parameter",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "A parameter that specifies the technical settings, environmental conditions, or experimental design of a chemotaxis assay involving Caenorhabditis elegans."
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000232",
+      "lbl" : "C. elegans chemotaxis assay parameter: chemoattractant mixture table",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "A table containing the quantities and identities of all chemicals used as a chemoattractant (e.g., isoamyl alcohol, diacetyl) to elicit a directed movement response in C. elegans."
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000233",
+      "lbl" : "C. elegans chemotaxis assay parameter: chemoattractant mixture volume",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "The volume of the chemoattractant mixture pipetted onto the agar plate in a chemotaxis assay. Unit: microliters (μL)."
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000234",
+      "lbl" : "C. elegans chemotaxis assay parameter: assay duration",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "The total time elapsed from the point at which C. elegans are placed on the assay plate until the movement is arrested or the final positions are recorded. Unit: minutes."
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000235",
+      "lbl" : "C. elegans chemotaxis assay measurement",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "A quantitative or qualitative value derived from a C. elegans chemotaxis assay, typically describing the efficiency or directionality of the animals' movement toward or away from a chemical source."
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000236",
+      "lbl" : "C. elegans chemotaxis assay measurement: McCutcheon index",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "A behavioral measurement of chemotactic efficiency defined as the ratio of the straight-line displacement toward the attractant to the total path length traveled by the organism. Values range from -1 to 1."
+        },
+        "synonyms" : [ {
+          "pred" : "hasExactSynonym",
+          "val" : "chemotactic ratio"
+        } ]
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000237",
+      "lbl" : "C. elegans chemotaxis assay measurement: mean velocity",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "The average speed of a C. elegans individual or population during the duration of the chemotaxis assay. Unit: micrometers per second (µm/s)."
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000238",
+      "lbl" : "investigator-defined strain",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "A specific genetic variant or line of an organism designated by the investigator, often containing unique mutations, transgenes, or genomic edits not yet categorized in a public repository."
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000239",
+      "lbl" : "C. elegans strain",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "A specific strain of Caenorhabditis elegans, identified by its genotype or a standard nomenclature (e.g., N2, CB4856), used in experimental procedures."
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000240",
+      "lbl" : "BAB9001",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "A C. elegans strain with the genotype daf-22 (m130). This strain was originally obtained from the Caenorhabditis Genetics Center (CGC) as strain DR476 and subsequently outcrossed three times. [Source: https://doi.org/TBD]"
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000241",
+      "lbl" : "BAB9002",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "A C. elegans klp-6 rescue strain with the genotype klp-6 (my8); Pklp-6::GFP::KLP-6 (array, IndEx 9002). [Source: https://doi.org/TBD]"
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000242",
+      "lbl" : "TM5848",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "A C. elegans strain with the genotype cil-7 (tm5848) I, exhibiting a him phenotype. This strain was obtained from the National BioResource Project (NBRP), Japan. [Source: https://doi.org/TBD]"
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000243",
+      "lbl" : "PT3602",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "A C. elegans strain with the genotype cil-7 (my61[cil-7::mNG])I; him-5(e1490) V. This strain was provided as a gift from the Maureen Barr lab. [Source: https://doi.org/TBD]"
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000244",
+      "lbl" : "BAB9003",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "A C. elegans strain with the genotype PT3602; Pnlp-43_hCaspase nZ (array IndEx 9003). [Source: https://doi.org/TBD]"
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000245",
+      "lbl" : "BAB9004",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "A C. elegans strain with the genotype PT3602; Pklp-6_hCaspase Cz (array IndEx 9004). [Source: https://doi.org/TBD]"
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000246",
+      "lbl" : "BAB9005",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "A C. elegans strain with the genotype PT3602; Pnlp-43_hCaspase nZ (array IndEx 9003) and Pklp-6_hCaspase Cz (array IndEx 9004). [Source: https://doi.org/TBD]"
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000247",
+      "lbl" : "fluorescence imaging measurement",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "fluorescence imaging measurement"
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000248",
+      "lbl" : "mean fluorescence intensity",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "Mean fluorescence intensity. Unit: arbitrary units (AU)"
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000249",
+      "lbl" : "fluorescent punctal count",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "A quantitative measurement of the number of distinct fluorescent spots or puncta detected within a defined region of interest in a fluorescence image. Unit: count"
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000250",
+      "lbl" : "fluorescence imaging parameter",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "A specific parameter related to fluorescence imaging acquisition or assay."
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000251",
+      "lbl" : "fluorescence target ontology identifier",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "fluorescence target ontology identifier"
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000252",
+      "lbl" : "fluorescence target name",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "fluorescence target name"
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000253",
+      "lbl" : "SnapGene file format",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "A .dna file format designed for storing annotated DNA sequences, including linear/circular topology, features, primers, and enzyme sites."
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000254",
+      "lbl" : "Escherichia coli OP50: heat-killed",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "A preparation of Escherichia coli strain OP50 that has been rendered non-viable through the application of heat, typically used as a non-proliferating food source in C. elegans assays."
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000255",
+      "lbl" : "C. elegans transfer method: M9 buffer wash",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "Method used to transfer C. elegans whereby an M9 buffer is used to wash C. elegans off of an agar plate. Animals can then be transferred using a piper."
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000256",
+      "lbl" : "C. elegans transfer method: titanium pick",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "Method used to transfer C. elegans whereby a titanium pick is used to scoop animals off of an agar plate."
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000257",
+      "lbl" : "C. elegans chemotaxis assay: video recording",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "A video recording capturing the behavior of C. elegans during a chemotaxis assay."
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/EMPTY_0000258",
+      "lbl" : "fluorescence imaging data",
+      "type" : "CLASS",
+      "meta" : {
+        "definition" : {
+          "val" : "An image or video acquired using fluorescence microscopy."
+        }
+      }
     }, {
       "id" : "http://purl.obolibrary.org/obo/ENVO_00000447",
       "type" : "CLASS"
@@ -15958,6 +16250,10 @@
       "id" : "http://purl.obolibrary.org/obo/GO_0010070",
       "lbl" : "zygote asymmetric cell division",
       "type" : "CLASS"
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/GO_0010155",
+      "lbl" : "regulation of proton transport",
+      "type" : "CLASS"
     }, {
       "id" : "http://purl.obolibrary.org/obo/GO_0010160",
       "lbl" : "formation of animal organ boundary",
@@ -16958,14 +17254,6 @@
       "id" : "http://purl.obolibrary.org/obo/GO_0014874",
       "lbl" : "response to stimulus involved in regulation of muscle adaptation",
       "type" : "CLASS"
-    }, {
-      "id" : "http://purl.obolibrary.org/obo/GO_0014878",
-      "lbl" : "response to electrical stimulus involved in regulation of muscle adaptation",
-      "type" : "CLASS"
-    }, {
-      "id" : "http://purl.obolibrary.org/obo/GO_0014879",
-      "lbl" : "detection of electrical stimulus involved in regulation of muscle adaptation",
-      "type" : "CLASS"
     }, {
       "id" : "http://purl.obolibrary.org/obo/GO_0014887",
       "lbl" : "cardiac muscle adaptation",
@@ -17024,6 +17312,19 @@
           "val" : "ion transporter activity"
         } ]
       }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/GO_0015078",
+      "lbl" : "proton transmembrane transporter activity",
+      "type" : "CLASS",
+      "meta" : {
+        "synonyms" : [ {
+          "pred" : "hasExactSynonym",
+          "val" : "hydrogen ion transmembrane transporter activity"
+        }, {
+          "pred" : "hasExactSynonym",
+          "val" : "proton transporter activity"
+        } ]
+      }
     }, {
       "id" : "http://purl.obolibrary.org/obo/GO_0015081",
       "lbl" : "sodium ion transmembrane transporter activity",
@@ -24603,7 +24904,11 @@
       "meta" : {
         "definition" : {
           "val" : "Any constituent part of a virion, a complete fully infectious extracellular virus particle."
-        }
+        },
+        "synonyms" : [ {
+          "pred" : "hasExactSynonym",
+          "val" : "virion part"
+        } ]
       }
     }, {
       "id" : "http://purl.obolibrary.org/obo/GO_0044458",
@@ -29824,10 +30129,6 @@
           "val" : "upregulation of pigment cell differentiation"
         } ]
       }
-    }, {
-      "id" : "http://purl.obolibrary.org/obo/GO_0050952",
-      "lbl" : "sensory perception of electrical stimulus",
-      "type" : "CLASS"
     }, {
       "id" : "http://purl.obolibrary.org/obo/GO_0050953",
       "lbl" : "sensory perception of light stimulus",
@@ -29845,19 +30146,6 @@
           "val" : "perception of mechanical stimulus"
         } ]
       }
-    }, {
-      "id" : "http://purl.obolibrary.org/obo/GO_0050956",
-      "lbl" : "electroception",
-      "type" : "CLASS",
-      "meta" : {
-        "synonyms" : [ {
-          "pred" : "hasExactSynonym",
-          "val" : "electroception sense"
-        }, {
-          "pred" : "hasExactSynonym",
-          "val" : "electroceptive sense"
-        } ]
-      }
     }, {
       "id" : "http://purl.obolibrary.org/obo/GO_0050962",
       "lbl" : "detection of light stimulus involved in sensory perception",
@@ -29883,66 +30171,6 @@
           "val" : "sensory transduction of light stimulus during sensory perception"
         } ]
       }
-    }, {
-      "id" : "http://purl.obolibrary.org/obo/GO_0050963",
-      "lbl" : "detection of electrical stimulus involved in sensory perception",
-      "type" : "CLASS",
-      "meta" : {
-        "synonyms" : [ {
-          "pred" : "hasExactSynonym",
-          "val" : "sensory detection of electrical stimulus"
-        }, {
-          "pred" : "hasExactSynonym",
-          "val" : "sensory detection of electrical stimulus during sensory perception"
-        }, {
-          "pred" : "hasExactSynonym",
-          "val" : "sensory perception, sensory detection of electrical stimulus"
-        }, {
-          "pred" : "hasExactSynonym",
-          "val" : "sensory perception, sensory transduction of electrical stimulus"
-        }, {
-          "pred" : "hasExactSynonym",
-          "val" : "sensory transduction of electrical stimulus"
-        }, {
-          "pred" : "hasExactSynonym",
-          "val" : "sensory transduction of electrical stimulus during sensory perception"
-        } ]
-      }
-    }, {
-      "id" : "http://purl.obolibrary.org/obo/GO_0050964",
-      "lbl" : "detection of electrical stimulus involved in electroception",
-      "type" : "CLASS",
-      "meta" : {
-        "synonyms" : [ {
-          "pred" : "hasExactSynonym",
-          "val" : "electroception, detection of electrical stimulus"
-        }, {
-          "pred" : "hasExactSynonym",
-          "val" : "electroception, sensory detection of electrical stimulus"
-        }, {
-          "pred" : "hasExactSynonym",
-          "val" : "electroception, sensory transduction"
-        }, {
-          "pred" : "hasExactSynonym",
-          "val" : "electroception, sensory transduction of electrical stimulus"
-        } ]
-      }
-    }, {
-      "id" : "http://purl.obolibrary.org/obo/GO_0050967",
-      "lbl" : "detection of electrical stimulus involved in sensory perception of pain",
-      "type" : "CLASS",
-      "meta" : {
-        "synonyms" : [ {
-          "pred" : "hasExactSynonym",
-          "val" : "perception of pain, detection of electrical stimulus"
-        }, {
-          "pred" : "hasExactSynonym",
-          "val" : "perception of pain, sensory detection of electrical stimulus"
-        }, {
-          "pred" : "hasExactSynonym",
-          "val" : "perception of pain, sensory transduction of electrical stimulus"
-        } ]
-      }
     }, {
       "id" : "http://purl.obolibrary.org/obo/GO_0050968",
       "lbl" : "detection of chemical stimulus involved in sensory perception of pain",
@@ -29984,10 +30212,6 @@
           "val" : "tactition"
         } ]
       }
-    }, {
-      "id" : "http://purl.obolibrary.org/obo/GO_0050981",
-      "lbl" : "detection of electrical stimulus",
-      "type" : "CLASS"
     }, {
       "id" : "http://purl.obolibrary.org/obo/GO_0050994",
       "lbl" : "regulation of lipid catabolic process",
@@ -31051,10 +31275,6 @@
           "val" : "upregulation of neurotransmitter transport"
         } ]
       }
-    }, {
-      "id" : "http://purl.obolibrary.org/obo/GO_0051602",
-      "lbl" : "response to electrical stimulus",
-      "type" : "CLASS"
     }, {
       "id" : "http://purl.obolibrary.org/obo/GO_0051606",
       "lbl" : "detection of stimulus",
@@ -35960,6 +36180,16 @@
       "id" : "http://purl.obolibrary.org/obo/GO_0120025",
       "lbl" : "plasma membrane bounded cell projection",
       "type" : "CLASS"
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/GO_0120029",
+      "lbl" : "proton export across plasma membrane",
+      "type" : "CLASS",
+      "meta" : {
+        "synonyms" : [ {
+          "pred" : "hasExactSynonym",
+          "val" : "hydrogen ion export across plasma membrane"
+        } ]
+      }
     }, {
       "id" : "http://purl.obolibrary.org/obo/GO_0120031",
       "lbl" : "plasma membrane bounded cell projection assembly",
@@ -37574,6 +37804,19 @@
       "id" : "http://purl.obolibrary.org/obo/GO_1902570",
       "lbl" : "protein localization to nucleolus",
       "type" : "CLASS"
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/GO_1902600",
+      "lbl" : "proton transmembrane transport",
+      "type" : "CLASS",
+      "meta" : {
+        "synonyms" : [ {
+          "pred" : "hasExactSynonym",
+          "val" : "hydrogen ion transmembrane transport"
+        }, {
+          "pred" : "hasExactSynonym",
+          "val" : "hydrogen transmembrane transport"
+        } ]
+      }
     }, {
       "id" : "http://purl.obolibrary.org/obo/GO_1902679",
       "lbl" : "negative regulation of RNA biosynthetic process",
@@ -40666,6 +40909,14 @@
       "id" : "http://purl.obolibrary.org/obo/NCBITaxon_1206795",
       "lbl" : "Lophotrochozoa",
       "type" : "CLASS"
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/NCBITaxon_1224",
+      "lbl" : "Pseudomonadota",
+      "type" : "CLASS"
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/NCBITaxon_1236",
+      "lbl" : "Gammaproteobacteria",
+      "type" : "CLASS"
     }, {
       "id" : "http://purl.obolibrary.org/obo/NCBITaxon_124129",
       "lbl" : "Acipenserinae",
@@ -40840,9 +41091,6 @@
       "type" : "CLASS",
       "meta" : {
         "basicPropertyValues" : [ {
-          "pred" : "http://purl.obolibrary.org/obo/IAO_0000118",
-          "val" : "eucaryotes"
-        }, {
           "pred" : "http://purl.obolibrary.org/obo/IAO_0000118",
           "val" : "eukaryotes"
         } ]
@@ -40957,6 +41205,9 @@
       "type" : "CLASS",
       "meta" : {
         "basicPropertyValues" : [ {
+          "pred" : "http://purl.obolibrary.org/obo/IAO_0000118",
+          "val" : "animals"
+        }, {
           "pred" : "http://purl.obolibrary.org/obo/IAO_0000118",
           "val" : "metazoans"
         }, {
@@ -41004,6 +41255,10 @@
       "id" : "http://purl.obolibrary.org/obo/NCBITaxon_3378",
       "lbl" : "Gnetales",
       "type" : "CLASS"
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/NCBITaxon_3379134",
+      "lbl" : "Pseudomonadati",
+      "type" : "CLASS"
     }, {
       "id" : "http://purl.obolibrary.org/obo/NCBITaxon_3398",
       "lbl" : "Magnoliopsida",
@@ -41150,6 +41405,10 @@
       "id" : "http://purl.obolibrary.org/obo/NCBITaxon_50557",
       "lbl" : "Insecta",
       "type" : "CLASS"
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/NCBITaxon_543",
+      "lbl" : "Enterobacteriaceae",
+      "type" : "CLASS"
     }, {
       "id" : "http://purl.obolibrary.org/obo/NCBITaxon_554915",
       "lbl" : "Amoebozoa",
@@ -41162,6 +41421,14 @@
       "id" : "http://purl.obolibrary.org/obo/NCBITaxon_55885",
       "lbl" : "Peloderinae",
       "type" : "CLASS"
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/NCBITaxon_561",
+      "lbl" : "Escherichia",
+      "type" : "CLASS"
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/NCBITaxon_562",
+      "lbl" : "Escherichia coli",
+      "type" : "CLASS"
     }, {
       "id" : "http://purl.obolibrary.org/obo/NCBITaxon_5782",
       "lbl" : "Dictyostelium",
@@ -41222,6 +41489,10 @@
       "id" : "http://purl.obolibrary.org/obo/NCBITaxon_6362",
       "lbl" : "Sabellida",
       "type" : "CLASS"
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/NCBITaxon_637912",
+      "lbl" : "Escherichia coli OP50",
+      "type" : "CLASS"
     }, {
       "id" : "http://purl.obolibrary.org/obo/NCBITaxon_6656",
       "lbl" : "Arthropoda",
@@ -41443,6 +41714,10 @@
       "id" : "http://purl.obolibrary.org/obo/NCBITaxon_89593",
       "lbl" : "Craniata <chordates>",
       "type" : "CLASS"
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/NCBITaxon_91347",
+      "lbl" : "Enterobacterales",
+      "type" : "CLASS"
     }, {
       "id" : "http://purl.obolibrary.org/obo/NCBITaxon_9254",
       "lbl" : "Prototheria",
@@ -41527,10 +41802,22 @@
       "id" : "http://purl.obolibrary.org/obo/NCIT_C14376",
       "lbl" : "Other Organism Groupings",
       "type" : "CLASS"
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/NCIT_C16203",
+      "lbl" : "Clinical or Research Activity",
+      "type" : "CLASS"
     }, {
       "id" : "http://purl.obolibrary.org/obo/NCIT_C16847",
       "lbl" : "Technique",
       "type" : "CLASS"
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/NCIT_C16853",
+      "lbl" : "Microscopy",
+      "type" : "CLASS"
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/NCIT_C16856",
+      "lbl" : "Fluorescence Microscopy",
+      "type" : "CLASS"
     }, {
       "id" : "http://purl.obolibrary.org/obo/NCIT_C17187",
       "lbl" : "Technology",
@@ -41539,10 +41826,18 @@
       "id" : "http://purl.obolibrary.org/obo/NCIT_C172272",
       "lbl" : "Electronic File Content Type",
       "type" : "CLASS"
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/NCIT_C17369",
+      "lbl" : "Imaging Procedure",
+      "type" : "CLASS"
     }, {
       "id" : "http://purl.obolibrary.org/obo/NCIT_C179817",
       "lbl" : "Velocity",
       "type" : "CLASS"
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/NCIT_C17995",
+      "lbl" : "Light Microscopy",
+      "type" : "CLASS"
     }, {
       "id" : "http://purl.obolibrary.org/obo/NCIT_C18141",
       "lbl" : "Computer Sciences",
@@ -41599,6 +41894,10 @@
       "id" : "http://purl.obolibrary.org/obo/NCIT_C25206",
       "lbl" : "Temperature",
       "type" : "CLASS"
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/NCIT_C25218",
+      "lbl" : "Clinical Intervention or Procedure",
+      "type" : "CLASS"
     }, {
       "id" : "http://purl.obolibrary.org/obo/NCIT_C25284",
       "lbl" : "Type",
@@ -41607,6 +41906,10 @@
       "id" : "http://purl.obolibrary.org/obo/NCIT_C25285",
       "lbl" : "Diameter",
       "type" : "CLASS"
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/NCIT_C25294",
+      "lbl" : "Laboratory Procedure",
+      "type" : "CLASS"
     }, {
       "id" : "http://purl.obolibrary.org/obo/NCIT_C25335",
       "lbl" : "Volume",
@@ -41699,6 +42002,10 @@
       "id" : "http://purl.obolibrary.org/obo/NCIT_C73706",
       "lbl" : "Spatial Qualifier",
       "type" : "CLASS"
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/NCIT_C74957",
+      "lbl" : "Mixed Category Laboratory Procedure",
+      "type" : "CLASS"
     }, {
       "id" : "http://purl.obolibrary.org/obo/NCIT_C85776",
       "lbl" : "Optical Density Measurement",
@@ -44550,6 +44857,10 @@
       "id" : "http://purl.obolibrary.org/obo/UBERON_0000000",
       "lbl" : "processual entity",
       "type" : "CLASS"
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/UBERON_0000001",
+      "lbl" : "gross anatomical part",
+      "type" : "CLASS"
     }, {
       "id" : "http://purl.obolibrary.org/obo/UBERON_0000005",
       "lbl" : "chemosensory organ",
@@ -44765,6 +45076,9 @@
       "lbl" : "anatomical structure",
       "type" : "CLASS",
       "meta" : {
+        "definition" : {
+          "val" : "Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome."
+        },
         "synonyms" : [ {
           "pred" : "hasExactSynonym",
           "val" : "biological structure"
@@ -55591,19 +55905,6 @@
       "id" : "http://purl.obolibrary.org/obo/UBERON_0010499",
       "lbl" : "pseudostratified ciliated columnar epithelium",
       "type" : "CLASS"
-    }, {
-      "id" : "http://purl.obolibrary.org/obo/UBERON_0010521",
-      "lbl" : "electroreceptor organ",
-      "type" : "CLASS",
-      "meta" : {
-        "synonyms" : [ {
-          "pred" : "hasExactSynonym",
-          "val" : "electric sense organ"
-        }, {
-          "pred" : "hasExactSynonym",
-          "val" : "electroreception organ"
-        } ]
-      }
     }, {
       "id" : "http://purl.obolibrary.org/obo/UBERON_0010522",
       "lbl" : "replacement element",
@@ -58544,6 +58845,10 @@
           "val" : "rectal lamina propria"
         } ]
       }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/UBERON_8850001",
+      "lbl" : "epithelium of anorectum",
+      "type" : "CLASS"
     }, {
       "id" : "http://purl.obolibrary.org/obo/UO_0000001",
       "lbl" : "length unit",
@@ -58584,6 +58889,12 @@
       "id" : "http://purl.obolibrary.org/obo/UO_0000280",
       "lbl" : "rate unit",
       "type" : "CLASS"
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/format_1929",
+      "type" : "CLASS"
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/NCBITaxon:637912",
+      "type" : "CLASS"
     }, {
       "id" : "http://www.geneontology.org/formats/oboInOwl#ObsoleteClass",
       "lbl" : "Obsolete Class",
@@ -61132,6 +61443,89 @@
           "val" : "X device utilizes material Y means X and Y are material entities, and X is capable of some process P that has input Y."
         }
       }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/RO_0018030",
+      "lbl" : "chemical relationship",
+      "type" : "PROPERTY",
+      "propertyType" : "OBJECT"
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/RO_0018033",
+      "lbl" : "is deprotonated form of",
+      "type" : "PROPERTY",
+      "propertyType" : "OBJECT",
+      "meta" : {
+        "definition" : {
+          "val" : "A is a deprotonated form of B if and only if A is chemical entity that is a Brønsted–Lowry Base (i.e., can receive a proton) and by adding some nonzero number of protons transforms it into B.\n\nThis is a transitive relationship and follows this design pattern: https://oborel.github.io/obo-relations/direct-and-indirect-relations."
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/RO_0018034",
+      "lbl" : "is protonated form of",
+      "type" : "PROPERTY",
+      "propertyType" : "OBJECT",
+      "meta" : {
+        "definition" : {
+          "val" : "A is a protonated form of B if and only if A is chemical entity that is a Brønsted–Lowry Acid (i.e., can give up a proton) and by removing some nonzero number of protons transforms it into B.\n\nThis is a transitive relationship and follows this design pattern: https://oborel.github.io/obo-relations/direct-and-indirect-relations."
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/RO_0018036",
+      "lbl" : "is tautomer of",
+      "type" : "PROPERTY",
+      "propertyType" : "OBJECT",
+      "meta" : {
+        "definition" : {
+          "val" : "Two chemicals are tautomers if they can be readily interconverted.\n\nThis commonly refers to prototropy in which a hydrogen's position is changed, such as between ketones and enols. This is also often observed in heterocyclic rings, e.g., ones containing nitrogens and/or have aryl functional groups containing heteroatoms."
+        },
+        "synonyms" : [ {
+          "pred" : "hasExactSynonym",
+          "val" : "is desmotrope of"
+        } ]
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/RO_0018037",
+      "lbl" : "is substitutent group from",
+      "type" : "PROPERTY",
+      "propertyType" : "OBJECT",
+      "meta" : {
+        "definition" : {
+          "val" : "Group A is a substituent group from Chemical B if A represents the functional part of A and includes information about where it is connected. A is not itself a chemical with a fully formed chemical graph, but is rather a partial graph with one or more connection points that can be used to attach to another chemical graph, typically as a functionalization."
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/RO_0018038",
+      "lbl" : "has functional parent",
+      "type" : "PROPERTY",
+      "propertyType" : "OBJECT",
+      "meta" : {
+        "definition" : {
+          "val" : "Chemical A has functional parent Chemical B if there is chemical transformation through which chemical B can be produced from chemical A. \n\nFor example, the relationship between a salt and a freebased compound is a \"has functional parent\" relationship."
+        }
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/RO_0018039",
+      "lbl" : "is enantiomer of",
+      "type" : "PROPERTY",
+      "propertyType" : "OBJECT",
+      "meta" : {
+        "definition" : {
+          "val" : "Chemicals A and B are enantiomers if they share the same molecular graph except the change of the configuration of substituents around exactly one chiral center.\n\nA chemical with no chiral centers can not have an enantiomer. A chemical with multiple chiral centers can have multiple enantiomers, but its enantiomers are not themselves enantiomers (they are diastereomers)."
+        },
+        "synonyms" : [ {
+          "pred" : "hasExactSynonym",
+          "val" : "is optical isomer of"
+        } ]
+      }
+    }, {
+      "id" : "http://purl.obolibrary.org/obo/RO_0018040",
+      "lbl" : "has parent hydride",
+      "type" : "PROPERTY",
+      "propertyType" : "OBJECT",
+      "meta" : {
+        "definition" : {
+          "val" : "Chemical A has parent hydride Chemical B if there exists a molecular graphical transformation where functional groups on A are replaced with hydrogens in order to yield B."
+        }
+      }
     }, {
       "id" : "http://purl.obolibrary.org/obo/RO_0019000",
       "lbl" : "regulates characteristic",
@@ -61232,10 +61626,6 @@
       "id" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of",
       "type" : "PROPERTY",
       "propertyType" : "OBJECT"
-    }, {
-      "id" : "http://purl.obolibrary.org/obo/chebi#is_enantiomer_of",
-      "type" : "PROPERTY",
-      "propertyType" : "OBJECT"
     }, {
       "id" : "http://purl.obolibrary.org/obo/chebi#is_substituent_group_from",
       "type" : "PROPERTY",
@@ -64469,7 +64859,7 @@
       "propertyType" : "ANNOTATION",
       "meta" : {
         "definition" : {
-          "val" : "The official definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions."
+          "val" : "The official definition."
         }
       }
     }, {
@@ -64592,6 +64982,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_132153",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_63551"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_132153",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_16336"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_132153",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of",
@@ -64624,6 +65018,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_13941",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_37022"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_13941",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_28616"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_13941",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of",
@@ -64634,7 +65032,7 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_26666"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_140601",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_78115"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_142163",
@@ -64654,12 +65052,12 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_78675"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_14321",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
-      "obj" : "http://purl.obolibrary.org/obo/CHEBI_29987"
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_18237"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_14321",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of",
-      "obj" : "http://purl.obolibrary.org/obo/CHEBI_18237"
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_29987"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_15339",
       "pred" : "is_a",
@@ -64716,10 +65114,30 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_15366",
       "pred" : "http://purl.obolibrary.org/obo/RO_0000087",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_83056"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_15366",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_30089"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_15366",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_30089"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_15378",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_25414"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_15378",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_33251"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_15378",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_33252"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_15378",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_60242"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_15379",
       "pred" : "is_a",
@@ -64760,6 +65178,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_15379",
       "pred" : "http://purl.obolibrary.org/obo/RO_0000087",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_77974"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_15379",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_29793"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_15379",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of",
@@ -64774,11 +65196,11 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_33704"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_15705",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_59814"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_15705",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_tautomer_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018036",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_59869"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_15841",
@@ -64802,11 +65224,11 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_76971"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_15966",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_29986"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_15966",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_enantiomer_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018039",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_16015"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_15986",
@@ -64854,11 +65276,11 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_76971"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_16015",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_29985"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_16015",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_enantiomer_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018039",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_15966"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_16134",
@@ -64896,6 +65318,14 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_16134",
       "pred" : "http://purl.obolibrary.org/obo/RO_0000087",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_78433"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_16134",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_28938"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_16134",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_29337"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_16134",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
@@ -64928,6 +65358,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_16189",
       "pred" : "http://purl.obolibrary.org/obo/RO_0000087",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_77746"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_16189",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_45696"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_16189",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of",
@@ -64944,6 +65378,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_16336",
       "pred" : "http://purl.obolibrary.org/obo/RO_0000087",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_77746"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_16336",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_132153"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_16336",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
@@ -64976,6 +65414,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_16670",
       "pred" : "http://purl.obolibrary.org/obo/BFO_0000051",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_33708"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_16670",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018036",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_60466"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_16670",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_tautomer_of",
@@ -64990,7 +65432,7 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_35274"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_166902",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_33569"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_16733",
@@ -64998,11 +65440,11 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_83925"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_16733",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_60895"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_16733",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_tautomer_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018036",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_59871"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_167559",
@@ -65036,6 +65478,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_16765",
       "pred" : "http://purl.obolibrary.org/obo/RO_0000087",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_77746"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_16765",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_57887"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_16765",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of",
@@ -65066,16 +65512,16 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_77746"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_16865",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#has_functional_parent",
-      "obj" : "http://purl.obolibrary.org/obo/CHEBI_30772"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/CHEBI_16865",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_30566"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_16865",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_tautomer_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018036",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_59888"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_16865",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018038",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_30772"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_16990",
       "pred" : "is_a",
@@ -65102,7 +65548,7 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_77746"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_16990",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_57977"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_17087",
@@ -65154,12 +65600,12 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_77746"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_17544",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
-      "obj" : "http://purl.obolibrary.org/obo/CHEBI_41609"
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_28976"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_17544",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of",
-      "obj" : "http://purl.obolibrary.org/obo/CHEBI_28976"
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_41609"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_17608",
       "pred" : "is_a",
@@ -65198,7 +65644,7 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_77746"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_17968",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_30772"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_18059",
@@ -65242,7 +65688,7 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_78675"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_18237",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_14321"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_18282",
@@ -65274,11 +65720,11 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_75771"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_18357",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_72587"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_18357",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_enantiomer_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018039",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_33571"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_20664",
@@ -65360,6 +65806,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_23004",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_27207"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_23004",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018037",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_28616"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_23004",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_substituent_group_from",
@@ -65376,6 +65826,18 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_23367",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_24431"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_234420",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_166902"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_234420",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_33571"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_234420",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018039",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_72587"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_23449",
       "pred" : "is_a",
@@ -65459,7 +65921,11 @@
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_24636",
       "pred" : "is_a",
-      "obj" : "http://purl.obolibrary.org/obo/CHEBI_36342"
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_15378"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_24636",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_33253"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_24636",
       "pred" : "is_a",
@@ -65490,7 +65956,7 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_36248"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_24663",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#has_functional_parent",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018038",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_36238"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_24828",
@@ -65532,10 +65998,6 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_24866",
       "pred" : "http://purl.obolibrary.org/obo/BFO_0000051",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_22563"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/CHEBI_24866",
-      "pred" : "http://purl.obolibrary.org/obo/BFO_0000051",
-      "obj" : "http://purl.obolibrary.org/obo/CHEBI_36916"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_24867",
       "pred" : "is_a",
@@ -65592,6 +66054,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_25384",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_33575"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_25384",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_35757"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_25384",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
@@ -65648,6 +66114,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_25704",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_26820"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_25704",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_58958"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_25704",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
@@ -65694,7 +66164,7 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_33709"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_26167",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_tautomer_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018036",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_62031"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_26607",
@@ -65706,7 +66176,7 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_35366"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_26666",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_58951"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_26708",
@@ -65788,6 +66258,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_26836",
       "pred" : "http://purl.obolibrary.org/obo/RO_0000087",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_35223"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_26836",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_45696"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_26836",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
@@ -65864,6 +66338,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_28616",
       "pred" : "http://purl.obolibrary.org/obo/RO_0000087",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_76971"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_28616",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_13941"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_28616",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
@@ -65900,6 +66378,14 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_28790",
       "pred" : "http://purl.obolibrary.org/obo/RO_0000087",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_77746"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_28790",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_350546"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_28790",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018038",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_16765"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_28790",
       "pred" : "http://purl.obolibrary.org/obo/chebi#has_functional_parent",
@@ -65918,7 +66404,7 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_35757"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_28868",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_35366"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_28938",
@@ -65948,6 +66434,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_28938",
       "pred" : "http://purl.obolibrary.org/obo/RO_0000087",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_77746"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_28938",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_16134"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_28938",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
@@ -65974,7 +66464,7 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_75771"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_28976",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_17544"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_29067",
@@ -65984,6 +66474,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_29067",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_35406"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_29067",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_33575"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_29067",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of",
@@ -66020,6 +66514,14 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_29337",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_79389"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_29337",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_16134"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_29337",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_29340"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_29337",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
@@ -66036,6 +66538,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_29340",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_79388"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_29340",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_29337"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_29340",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of",
@@ -66044,6 +66550,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_29793",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_33693"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_29793",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_15379"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_29793",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
@@ -66066,15 +66576,15 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_77746"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_29985",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
-      "obj" : "http://purl.obolibrary.org/obo/CHEBI_29988"
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_16015"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_29985",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of",
-      "obj" : "http://purl.obolibrary.org/obo/CHEBI_16015"
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_29988"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_29985",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_enantiomer_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018039",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_29986"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_29986",
@@ -66082,15 +66592,15 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_14321"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_29986",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
-      "obj" : "http://purl.obolibrary.org/obo/CHEBI_29989"
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_15966"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_29986",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of",
-      "obj" : "http://purl.obolibrary.org/obo/CHEBI_15966"
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_29989"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_29986",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_enantiomer_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018039",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_29985"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_29987",
@@ -66102,7 +66612,7 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_78675"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_29987",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_14321"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_29988",
@@ -66114,11 +66624,11 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_59814"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_29988",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_29985"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_29988",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_enantiomer_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018039",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_29989"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_29989",
@@ -66126,11 +66636,11 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_29987"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_29989",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_29986"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_29989",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_enantiomer_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018039",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_29988"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_30089",
@@ -66144,6 +66654,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_30089",
       "pred" : "http://purl.obolibrary.org/obo/RO_0000087",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_77746"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_30089",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_15366"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_30089",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of",
@@ -66162,12 +66676,12 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_77746"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_30566",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#has_functional_parent",
-      "obj" : "http://purl.obolibrary.org/obo/CHEBI_17968"
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_16865"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_30566",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of",
-      "obj" : "http://purl.obolibrary.org/obo/CHEBI_16865"
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018038",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_17968"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_30772",
       "pred" : "is_a",
@@ -66186,7 +66700,7 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_84087"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_30772",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_17968"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_3098",
@@ -66220,6 +66734,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_33241",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_37577"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_33241",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018038",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_24833"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_33241",
       "pred" : "http://purl.obolibrary.org/obo/chebi#has_functional_parent",
@@ -66248,6 +66766,14 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_33247",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_24433"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_33247",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_64769"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_33247",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_64775"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_33247",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
@@ -66264,14 +66790,18 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_33250",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_24431"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/CHEBI_33250",
-      "pred" : "http://purl.obolibrary.org/obo/BFO_0000051",
-      "obj" : "http://purl.obolibrary.org/obo/CHEBI_10545"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_33250",
       "pred" : "http://purl.obolibrary.org/obo/BFO_0000051",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_33252"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_33251",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_33238"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_33251",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_33260"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_33252",
       "pred" : "is_a",
@@ -66296,6 +66826,18 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_33259",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_23367"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_33260",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_24835"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_33260",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_33259"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_33260",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_33608"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_33262",
       "pred" : "is_a",
@@ -66432,6 +66974,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_33558",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_37022"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_33558",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_33704"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_33558",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of",
@@ -66466,7 +67012,7 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_76967"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_33569",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_166902"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_33570",
@@ -66478,7 +67024,11 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_33569"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_33571",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_enantiomer_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_234420"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_33571",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018039",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_18357"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_33575",
@@ -66496,6 +67046,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_33575",
       "pred" : "http://purl.obolibrary.org/obo/BFO_0000051",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_46883"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_33575",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_29067"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_33575",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
@@ -66524,10 +67078,6 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_33608",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_33674"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/CHEBI_33608",
-      "pred" : "http://purl.obolibrary.org/obo/BFO_0000051",
-      "obj" : "http://purl.obolibrary.org/obo/CHEBI_49637"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_33635",
       "pred" : "is_a",
@@ -66568,10 +67118,6 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_33674",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_33579"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/CHEBI_33674",
-      "pred" : "http://purl.obolibrary.org/obo/BFO_0000051",
-      "obj" : "http://purl.obolibrary.org/obo/CHEBI_33559"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_33675",
       "pred" : "is_a",
@@ -66648,6 +67194,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_33703",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_33702"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_33703",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_33709"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_33703",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
@@ -66656,6 +67206,18 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_33704",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_33709"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_33704",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_33719"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_33704",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_33558"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_33704",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018036",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_78608"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_33704",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
@@ -66674,12 +67236,24 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_83820"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_33707",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_71666"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_33708",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_33247"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_33708",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_58942"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_33708",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_64898"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_33708",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018037",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_33709"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_33708",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
@@ -66700,6 +67274,14 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_33709",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_50047"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_33709",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_33703"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_33709",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_37022"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_33709",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
@@ -66712,6 +67294,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_33710",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_33708"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_33710",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018037",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_33704"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_33710",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_substituent_group_from",
@@ -66720,6 +67306,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_33719",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_33703"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_33719",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_33704"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_33719",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
@@ -66732,6 +67322,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_33720",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_33575"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_33720",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_33721"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_33720",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
@@ -66740,6 +67334,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_33721",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_29067"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_33721",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_33720"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_33721",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of",
@@ -66824,6 +67422,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_350546",
       "pred" : "http://purl.obolibrary.org/obo/RO_0000087",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_77746"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_350546",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_28790"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_350546",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
@@ -66868,6 +67470,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_35274",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_51143"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_35274",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018040",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_28938"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_35274",
       "pred" : "http://purl.obolibrary.org/obo/chebi#has_parent_hydride",
@@ -66910,7 +67516,7 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_25384"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_35366",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_28868"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_35381",
@@ -67006,7 +67612,7 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_33575"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_35692",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_35693"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_35693",
@@ -67014,7 +67620,7 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_29067"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_35693",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_35692"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_35701",
@@ -67044,6 +67650,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_35757",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_29067"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_35757",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_25384"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_35757",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of",
@@ -67070,7 +67680,7 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_35341"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_36078",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#has_parent_hydride",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018040",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_35519"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_36080",
@@ -67122,7 +67732,7 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_36278"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_36248",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#has_parent_hydride",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018040",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_20664"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_36277",
@@ -67276,6 +67886,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_37022",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_35352"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_37022",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_33709"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_37022",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of",
@@ -67336,6 +67950,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_37826",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_33424"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_37826",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018038",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_26836"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_37826",
       "pred" : "http://purl.obolibrary.org/obo/chebi#has_functional_parent",
@@ -67344,6 +67962,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_37838",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_22221"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_37838",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018037",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_33575"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_37838",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_substituent_group_from",
@@ -67450,7 +68072,7 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_59202"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_39418",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_58954"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_41609",
@@ -67458,7 +68080,7 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_35604"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_41609",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_17544"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_4167",
@@ -67496,6 +68118,14 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_45696",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_33482"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_45696",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_26836"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_45696",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_16189"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_45696",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
@@ -67524,6 +68154,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_47622",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_33308"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_47622",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018038",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_15366"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_47622",
       "pred" : "http://purl.obolibrary.org/obo/chebi#has_functional_parent",
@@ -67538,7 +68172,7 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_64709"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_47891",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_50160"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_48154",
@@ -67592,6 +68226,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_50047",
       "pred" : "http://purl.obolibrary.org/obo/RO_0000087",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_39142"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_50047",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018040",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_16134"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_50047",
       "pred" : "http://purl.obolibrary.org/obo/chebi#has_parent_hydride",
@@ -67602,7 +68240,7 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_29067"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_50160",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_47891"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_50297",
@@ -67664,6 +68302,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_50994",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_50047"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_50994",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_65296"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_50994",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of",
@@ -67764,6 +68406,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_57887",
       "pred" : "http://purl.obolibrary.org/obo/RO_0000087",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_77746"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_57887",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_16765"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_57887",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
@@ -67782,12 +68428,16 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_77746"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_57977",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_16990"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_58942",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_64769"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_58942",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_33708"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_58942",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
@@ -67798,7 +68448,7 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_28868"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_58951",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_26666"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_58953",
@@ -67810,7 +68460,7 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_58953"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_58954",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_39418"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_58958",
@@ -67820,6 +68470,14 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_58958",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_33482"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_58958",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_25704"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_58958",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018038",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_16189"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_58958",
       "pred" : "http://purl.obolibrary.org/obo/chebi#has_functional_parent",
@@ -67834,7 +68492,7 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_35366"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_59202",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_59203"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_59203",
@@ -67842,7 +68500,7 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_28868"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_59203",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_59202"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_59252",
@@ -67862,7 +68520,7 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_33558"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_59814",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_15705"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_59869",
@@ -67870,7 +68528,7 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_78608"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_59869",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_tautomer_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018036",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_15705"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_59871",
@@ -67878,7 +68536,7 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_35238"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_59871",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_tautomer_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018036",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_16733"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_59888",
@@ -67886,7 +68544,7 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_35238"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_59888",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_tautomer_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018036",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_16865"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_59999",
@@ -67920,6 +68578,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_60466",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_27369"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_60466",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018036",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_16670"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_60466",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_tautomer_of",
@@ -67930,7 +68592,7 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_33558"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_60895",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_16733"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_61115",
@@ -67944,6 +68606,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_61120",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_51143"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_61120",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018038",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_18282"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_61120",
       "pred" : "http://purl.obolibrary.org/obo/chebi#has_functional_parent",
@@ -67962,7 +68628,7 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_35238"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_62031",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_tautomer_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018036",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_26167"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_62488",
@@ -67976,6 +68642,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_63299",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_78616"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_63299",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018038",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_16646"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_63299",
       "pred" : "http://purl.obolibrary.org/obo/chebi#has_functional_parent",
@@ -67984,6 +68654,14 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_63436",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_63299"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_63436",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_63551"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_63436",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018038",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_33720"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_63436",
       "pred" : "http://purl.obolibrary.org/obo/chebi#has_functional_parent",
@@ -68000,6 +68678,14 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_63551",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_29067"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_63551",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_63436"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_63551",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018038",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_33721"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_63551",
       "pred" : "http://purl.obolibrary.org/obo/chebi#has_functional_parent",
@@ -68052,6 +68738,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_64769",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_64766"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_64769",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_33247"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_64769",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
@@ -68060,6 +68750,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_64775",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_64767"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_64775",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_33247"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_64775",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of",
@@ -68068,6 +68762,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_64898",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_64775"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_64898",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_33708"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_64898",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of",
@@ -68088,6 +68786,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_65212",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_63299"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_65212",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018038",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_18154"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_65212",
       "pred" : "http://purl.obolibrary.org/obo/chebi#has_functional_parent",
@@ -68112,6 +68814,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_65296",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_35274"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_65296",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_50994"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_65296",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
@@ -68126,7 +68832,7 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_37022"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_71666",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_33707"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_72587",
@@ -68138,8 +68844,12 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_77746"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_72587",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018034",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_18357"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_72587",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018039",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_234420"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_72695",
       "pred" : "is_a",
@@ -68258,7 +68968,7 @@
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_58953"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_78115",
-      "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018033",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_140601"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_78295",
@@ -68272,6 +68982,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_78608",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_35238"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CHEBI_78608",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0018036",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_33704"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CHEBI_78608",
       "pred" : "http://purl.obolibrary.org/obo/chebi#is_tautomer_of",
@@ -69120,6 +69834,10 @@
       "sub" : "http://purl.obolibrary.org/obo/CL_0000138",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/CL_0000667"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CL_0000138",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/CL_0007001"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/CL_0000138",
       "pred" : "http://purl.obolibrary.org/obo/RO_0001025",
@@ -76264,6 +76982,118 @@
       "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000230",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/NCIT_C172272"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000231",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000101"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000232",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000231"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000233",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000231"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000234",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000231"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000235",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000100"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000236",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000235"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000237",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000235"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000238",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000076"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000239",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000238"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000240",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000239"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000241",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000239"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000242",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000239"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000243",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000239"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000244",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000239"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000245",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000239"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000246",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000239"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000247",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000001"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000248",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000247"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000249",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000247"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000250",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000080"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000251",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000250"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000252",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000250"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000253",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/format_1929"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000254",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_637912"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000255",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000189"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000256",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000189"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000257",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/EMPTY_0000129"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/EMPTY_0000258",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/NCIT_C16856"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/GO_0000011",
       "pred" : "is_a",
@@ -82856,6 +83686,10 @@
       "sub" : "http://purl.obolibrary.org/obo/GO_0008150",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/BFO_0000015"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/GO_0008150",
+      "pred" : "http://purl.obolibrary.org/obo/BFO_0000051",
+      "obj" : "http://purl.obolibrary.org/obo/GO_0003674"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/GO_0008152",
       "pred" : "is_a",
@@ -83832,6 +84666,14 @@
       "sub" : "http://purl.obolibrary.org/obo/GO_0010070",
       "pred" : "http://purl.obolibrary.org/obo/RO_0004009",
       "obj" : "http://purl.obolibrary.org/obo/CL_0000365"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/GO_0010155",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/GO_1904062"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/GO_0010155",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0002211",
+      "obj" : "http://purl.obolibrary.org/obo/GO_1902600"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/GO_0010160",
       "pred" : "is_a",
@@ -85952,22 +86794,6 @@
       "sub" : "http://purl.obolibrary.org/obo/GO_0014874",
       "pred" : "http://purl.obolibrary.org/obo/BFO_0000050",
       "obj" : "http://purl.obolibrary.org/obo/GO_0043502"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/GO_0014878",
-      "pred" : "is_a",
-      "obj" : "http://purl.obolibrary.org/obo/GO_0014874"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/GO_0014878",
-      "pred" : "is_a",
-      "obj" : "http://purl.obolibrary.org/obo/GO_0051602"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/GO_0014879",
-      "pred" : "is_a",
-      "obj" : "http://purl.obolibrary.org/obo/GO_0014878"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/GO_0014879",
-      "pred" : "is_a",
-      "obj" : "http://purl.obolibrary.org/obo/GO_0050981"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/GO_0014887",
       "pred" : "is_a",
@@ -86088,6 +86914,18 @@
       "sub" : "http://purl.obolibrary.org/obo/GO_0015075",
       "pred" : "http://purl.obolibrary.org/obo/RO_0004009",
       "obj" : "http://purl.obolibrary.org/obo/CHEBI_24867"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/GO_0015078",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/GO_0008324"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/GO_0015078",
+      "pred" : "http://purl.obolibrary.org/obo/BFO_0000050",
+      "obj" : "http://purl.obolibrary.org/obo/GO_1902600"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/GO_0015078",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0004009",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_15378"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/GO_0015081",
       "pred" : "is_a",
@@ -100716,10 +101554,6 @@
       "sub" : "http://purl.obolibrary.org/obo/GO_0050942",
       "pred" : "http://purl.obolibrary.org/obo/RO_0002213",
       "obj" : "http://purl.obolibrary.org/obo/GO_0050931"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/GO_0050952",
-      "pred" : "is_a",
-      "obj" : "http://purl.obolibrary.org/obo/GO_0007600"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/GO_0050953",
       "pred" : "is_a",
@@ -100728,10 +101562,6 @@
       "sub" : "http://purl.obolibrary.org/obo/GO_0050954",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/GO_0007600"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/GO_0050956",
-      "pred" : "is_a",
-      "obj" : "http://purl.obolibrary.org/obo/GO_0050952"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/GO_0050962",
       "pred" : "is_a",
@@ -100744,34 +101574,6 @@
       "sub" : "http://purl.obolibrary.org/obo/GO_0050962",
       "pred" : "http://purl.obolibrary.org/obo/BFO_0000050",
       "obj" : "http://purl.obolibrary.org/obo/GO_0050953"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/GO_0050963",
-      "pred" : "is_a",
-      "obj" : "http://purl.obolibrary.org/obo/GO_0050906"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/GO_0050963",
-      "pred" : "is_a",
-      "obj" : "http://purl.obolibrary.org/obo/GO_0050981"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/GO_0050963",
-      "pred" : "http://purl.obolibrary.org/obo/BFO_0000050",
-      "obj" : "http://purl.obolibrary.org/obo/GO_0050952"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/GO_0050964",
-      "pred" : "is_a",
-      "obj" : "http://purl.obolibrary.org/obo/GO_0050963"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/GO_0050964",
-      "pred" : "http://purl.obolibrary.org/obo/BFO_0000050",
-      "obj" : "http://purl.obolibrary.org/obo/GO_0050956"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/GO_0050967",
-      "pred" : "is_a",
-      "obj" : "http://purl.obolibrary.org/obo/GO_0050963"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/GO_0050967",
-      "pred" : "is_a",
-      "obj" : "http://purl.obolibrary.org/obo/GO_0062149"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/GO_0050968",
       "pred" : "is_a",
@@ -100784,14 +101586,6 @@
       "sub" : "http://purl.obolibrary.org/obo/GO_0050975",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/GO_0050954"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/GO_0050981",
-      "pred" : "is_a",
-      "obj" : "http://purl.obolibrary.org/obo/GO_0009582"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/GO_0050981",
-      "pred" : "is_a",
-      "obj" : "http://purl.obolibrary.org/obo/GO_0051602"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/GO_0050994",
       "pred" : "is_a",
@@ -101696,10 +102490,6 @@
       "sub" : "http://purl.obolibrary.org/obo/GO_0051590",
       "pred" : "http://purl.obolibrary.org/obo/RO_0002213",
       "obj" : "http://purl.obolibrary.org/obo/GO_0006836"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/GO_0051602",
-      "pred" : "is_a",
-      "obj" : "http://purl.obolibrary.org/obo/GO_0009628"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/GO_0051606",
       "pred" : "is_a",
@@ -110756,6 +111546,14 @@
       "sub" : "http://purl.obolibrary.org/obo/GO_0120025",
       "pred" : "http://purl.obolibrary.org/obo/BFO_0000051",
       "obj" : "http://purl.obolibrary.org/obo/GO_0098590"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/GO_0120029",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/GO_0140115"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/GO_0120029",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/GO_1902600"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/GO_0120031",
       "pred" : "is_a",
@@ -114088,6 +114886,18 @@
       "sub" : "http://purl.obolibrary.org/obo/GO_1902570",
       "pred" : "http://purl.obolibrary.org/obo/RO_0002339",
       "obj" : "http://purl.obolibrary.org/obo/GO_0005730"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/GO_1902600",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/GO_0098655"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/GO_1902600",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/GO_0098662"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/GO_1902600",
+      "pred" : "http://purl.obolibrary.org/obo/RO_0004009",
+      "obj" : "http://purl.obolibrary.org/obo/CHEBI_15378"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/GO_1902679",
       "pred" : "is_a",
@@ -121504,6 +122314,14 @@
       "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_1206795",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_2697495"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_1224",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_3379134"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_1236",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_1224"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_124129",
       "pred" : "is_a",
@@ -121524,6 +122342,10 @@
       "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_1312402",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33213"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_131567",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/COB_0000022"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_131567",
       "pred" : "is_a",
@@ -121672,10 +122494,6 @@
       "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_2743711",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_2743709"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_2759",
-      "pred" : "is_a",
-      "obj" : "http://purl.obolibrary.org/obo/COB_0000022"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_2759",
       "pred" : "is_a",
@@ -121816,6 +122634,10 @@
       "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_3378",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_1445966"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_3379134",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_2"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_3398",
       "pred" : "is_a",
@@ -121956,6 +122778,10 @@
       "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_50557",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6960"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_543",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_91347"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_554915",
       "pred" : "is_a",
@@ -121968,6 +122794,14 @@
       "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_55885",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6243"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_561",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_543"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_562",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_561"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_5782",
       "pred" : "is_a",
@@ -122028,6 +122862,10 @@
       "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_6362",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_105391"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_637912",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_562"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_6656",
       "pred" : "is_a",
@@ -122240,6 +123078,10 @@
       "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_89593",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7711"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_91347",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_1236"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_9254",
       "pred" : "is_a",
@@ -122308,10 +123150,26 @@
       "sub" : "http://purl.obolibrary.org/obo/NCIT_C14376",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/NCIT_C14250"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/NCIT_C16203",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/NCIT_C43431"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/NCIT_C16847",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/NCIT_C43431"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/NCIT_C16853",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/NCIT_C17369"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/NCIT_C16853",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/NCIT_C74957"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/NCIT_C16856",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/NCIT_C17995"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/NCIT_C17187",
       "pred" : "is_a",
@@ -122320,6 +123178,10 @@
       "sub" : "http://purl.obolibrary.org/obo/NCIT_C172272",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/NCIT_C25284"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/NCIT_C17369",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/NCIT_C25218"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/NCIT_C179817",
       "pred" : "is_a",
@@ -122328,6 +123190,10 @@
       "sub" : "http://purl.obolibrary.org/obo/NCIT_C179817",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/NCIT_C70766"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/NCIT_C17995",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/NCIT_C16853"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/NCIT_C18141",
       "pred" : "is_a",
@@ -122380,6 +123246,10 @@
       "sub" : "http://purl.obolibrary.org/obo/NCIT_C25206",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/NCIT_C25447"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/NCIT_C25218",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/NCIT_C16203"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/NCIT_C25284",
       "pred" : "is_a",
@@ -122388,6 +123258,10 @@
       "sub" : "http://purl.obolibrary.org/obo/NCIT_C25285",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/NCIT_C70766"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/NCIT_C25294",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/NCIT_C25218"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/NCIT_C25335",
       "pred" : "is_a",
@@ -122480,6 +123354,10 @@
       "sub" : "http://purl.obolibrary.org/obo/NCIT_C73706",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/NCIT_C41009"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/NCIT_C74957",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/NCIT_C25294"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/NCIT_C85776",
       "pred" : "is_a",
@@ -124485,9 +125363,9 @@
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/BFO_0000040"
     }, {
-      "sub" : "http://purl.obolibrary.org/obo/UBERON_0000000",
+      "sub" : "http://purl.obolibrary.org/obo/UBERON_0000001",
       "pred" : "is_a",
-      "obj" : "http://purl.obolibrary.org/obo/BFO_0000003"
+      "obj" : "http://purl.obolibrary.org/obo/UBERON_0000465"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/UBERON_0000005",
       "pred" : "is_a",
@@ -125240,6 +126118,10 @@
       "sub" : "http://purl.obolibrary.org/obo/UBERON_0000102",
       "pred" : "http://purl.obolibrary.org/obo/BFO_0000050",
       "obj" : "http://purl.obolibrary.org/obo/UBERON_0002048"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/UBERON_0000104",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/BFO_0000015"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/UBERON_0000104",
       "pred" : "is_a",
@@ -125248,6 +126130,10 @@
       "sub" : "http://purl.obolibrary.org/obo/UBERON_0000104",
       "pred" : "http://purl.obolibrary.org/obo/RO_0002230",
       "obj" : "http://purl.obolibrary.org/obo/UBERON_0000071"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/UBERON_0000105",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/BFO_0000015"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/UBERON_0000105",
       "pred" : "is_a",
@@ -125600,10 +126486,6 @@
       "sub" : "http://purl.obolibrary.org/obo/UBERON_0000168",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/UBERON_0004921"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/UBERON_0000168",
-      "pred" : "http://purl.obolibrary.org/obo/BFO_0000050",
-      "obj" : "http://purl.obolibrary.org/obo/UBERON_0001155"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/UBERON_0000168",
       "pred" : "http://purl.obolibrary.org/obo/uberon/core#subdivision_of",
@@ -126147,7 +127029,7 @@
     }, {
       "sub" : "http://purl.obolibrary.org/obo/UBERON_0000463",
       "pred" : "is_a",
-      "obj" : "http://purl.obolibrary.org/obo/UBERON_0000465"
+      "obj" : "http://purl.obolibrary.org/obo/UBERON_0000001"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/UBERON_0000463",
       "pred" : "http://purl.obolibrary.org/obo/BFO_0000050",
@@ -126220,6 +127102,10 @@
       "sub" : "http://purl.obolibrary.org/obo/UBERON_0000475",
       "pred" : "http://purl.obolibrary.org/obo/BFO_0000050",
       "obj" : "http://purl.obolibrary.org/obo/UBERON_0000468"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/UBERON_0000476",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/UBERON_0000001"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/UBERON_0000476",
       "pred" : "is_a",
@@ -139264,10 +140150,6 @@
       "sub" : "http://purl.obolibrary.org/obo/UBERON_0004921",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/UBERON_0013522"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/UBERON_0004921",
-      "pred" : "http://purl.obolibrary.org/obo/BFO_0000050",
-      "obj" : "http://purl.obolibrary.org/obo/UBERON_0001555"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/UBERON_0004921",
       "pred" : "http://purl.obolibrary.org/obo/uberon/core#subdivision_of",
@@ -140151,7 +141033,7 @@
     }, {
       "sub" : "http://purl.obolibrary.org/obo/UBERON_0005423",
       "pred" : "is_a",
-      "obj" : "http://purl.obolibrary.org/obo/UBERON_0000465"
+      "obj" : "http://purl.obolibrary.org/obo/UBERON_0000001"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/UBERON_0005423",
       "pred" : "http://purl.obolibrary.org/obo/RO_0002215",
@@ -141260,10 +142142,6 @@
       "sub" : "http://purl.obolibrary.org/obo/UBERON_0006076",
       "pred" : "http://purl.obolibrary.org/obo/BFO_0000050",
       "obj" : "http://purl.obolibrary.org/obo/UBERON_0002090"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/UBERON_0006076",
-      "pred" : "http://purl.obolibrary.org/obo/BFO_0000050",
-      "obj" : "http://purl.obolibrary.org/obo/UBERON_0006071"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/UBERON_0006076",
       "pred" : "http://purl.obolibrary.org/obo/uberon/core#subdivision_of",
@@ -141272,10 +142150,6 @@
       "sub" : "http://purl.obolibrary.org/obo/UBERON_0006077",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/UBERON_0000075"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/UBERON_0006077",
-      "pred" : "http://purl.obolibrary.org/obo/BFO_0000050",
-      "obj" : "http://purl.obolibrary.org/obo/UBERON_0001130"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/UBERON_0006077",
       "pred" : "http://purl.obolibrary.org/obo/BFO_0000050",
@@ -144336,10 +145210,6 @@
       "sub" : "http://purl.obolibrary.org/obo/UBERON_0009568",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/UBERON_0006077"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/UBERON_0009568",
-      "pred" : "http://purl.obolibrary.org/obo/BFO_0000050",
-      "obj" : "http://purl.obolibrary.org/obo/UBERON_0002100"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/UBERON_0009568",
       "pred" : "http://purl.obolibrary.org/obo/uberon/core#subdivision_of",
@@ -146140,14 +147010,6 @@
       "sub" : "http://purl.obolibrary.org/obo/UBERON_0010499",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/UBERON_0010498"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/UBERON_0010521",
-      "pred" : "is_a",
-      "obj" : "http://purl.obolibrary.org/obo/UBERON_0000020"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/UBERON_0010521",
-      "pred" : "http://purl.obolibrary.org/obo/RO_0002215",
-      "obj" : "http://purl.obolibrary.org/obo/GO_0050964"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/UBERON_0010522",
       "pred" : "is_a",
@@ -147916,10 +148778,6 @@
       "sub" : "http://purl.obolibrary.org/obo/UBERON_0013522",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/UBERON_0000064"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/UBERON_0013522",
-      "pred" : "http://purl.obolibrary.org/obo/BFO_0000050",
-      "obj" : "http://purl.obolibrary.org/obo/UBERON_0000025"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/UBERON_0013522",
       "pred" : "http://purl.obolibrary.org/obo/BFO_0000051",
@@ -150495,7 +151353,7 @@
     }, {
       "sub" : "http://purl.obolibrary.org/obo/UBERON_0036215",
       "pred" : "is_a",
-      "obj" : "http://purl.obolibrary.org/obo/UBERON_0000465"
+      "obj" : "http://purl.obolibrary.org/obo/UBERON_0000001"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/UBERON_0036215",
       "pred" : "http://purl.obolibrary.org/obo/RO_0002007",
@@ -151388,6 +152246,14 @@
       "sub" : "http://purl.obolibrary.org/obo/UBERON_8600140",
       "pred" : "http://purl.obolibrary.org/obo/BFO_0000050",
       "obj" : "http://purl.obolibrary.org/obo/UBERON_0001052"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/UBERON_8850001",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/UBERON_0001278"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/UBERON_8850001",
+      "pred" : "http://purl.obolibrary.org/obo/BFO_0000050",
+      "obj" : "http://purl.obolibrary.org/obo/UBERON_8410050"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/UO_0000001",
       "pred" : "is_a",
@@ -154112,6 +154978,34 @@
       "sub" : "http://purl.obolibrary.org/obo/RO_0015016",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0002104"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/RO_0018033",
+      "pred" : "subPropertyOf",
+      "obj" : "http://purl.obolibrary.org/obo/RO_0018030"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/RO_0018034",
+      "pred" : "subPropertyOf",
+      "obj" : "http://purl.obolibrary.org/obo/RO_0018030"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/RO_0018036",
+      "pred" : "subPropertyOf",
+      "obj" : "http://purl.obolibrary.org/obo/RO_0018030"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/RO_0018037",
+      "pred" : "subPropertyOf",
+      "obj" : "http://purl.obolibrary.org/obo/RO_0018030"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/RO_0018038",
+      "pred" : "subPropertyOf",
+      "obj" : "http://purl.obolibrary.org/obo/RO_0018030"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/RO_0018039",
+      "pred" : "subPropertyOf",
+      "obj" : "http://purl.obolibrary.org/obo/RO_0018030"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/RO_0018040",
+      "pred" : "subPropertyOf",
+      "obj" : "http://purl.obolibrary.org/obo/RO_0018030"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0019000",
       "pred" : "subPropertyOf",
@@ -154188,6 +155082,10 @@
       "sub" : "http://purl.obolibrary.org/obo/uberon/core#proximally_connected_to",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/uberon/core#transitively_proximally_connected_to"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/uberon/core#subdivision_of",
+      "pred" : "subPropertyOf",
+      "obj" : "http://purl.obolibrary.org/obo/BFO_0000050"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/BFO_0000050",
       "pred" : "inverseOf",
@@ -154400,6 +155298,10 @@
       "sub" : "http://purl.obolibrary.org/obo/RO_0003000",
       "pred" : "inverseOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0003001"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/RO_0018033",
+      "pred" : "inverseOf",
+      "obj" : "http://purl.obolibrary.org/obo/RO_0018034"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/uberon/core#distally_connected_to",
       "pred" : "inverseOf",
@@ -162425,6 +163327,13 @@
         "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009",
         "fillerId" : "http://purl.obolibrary.org/obo/CL_0000365"
       } ]
+    }, {
+      "definedClassId" : "http://purl.obolibrary.org/obo/GO_0010155",
+      "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ],
+      "restrictions" : [ {
+        "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211",
+        "fillerId" : "http://purl.obolibrary.org/obo/GO_1902600"
+      } ]
     }, {
       "definedClassId" : "http://purl.obolibrary.org/obo/GO_0010160",
       "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048859" ],
@@ -163670,20 +164579,6 @@
         "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050",
         "fillerId" : "http://purl.obolibrary.org/obo/GO_0043502"
       } ]
-    }, {
-      "definedClassId" : "http://purl.obolibrary.org/obo/GO_0014878",
-      "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0051602" ],
-      "restrictions" : [ {
-        "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050",
-        "fillerId" : "http://purl.obolibrary.org/obo/GO_0043502"
-      } ]
-    }, {
-      "definedClassId" : "http://purl.obolibrary.org/obo/GO_0014879",
-      "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0050981" ],
-      "restrictions" : [ {
-        "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050",
-        "fillerId" : "http://purl.obolibrary.org/obo/GO_0043502"
-      } ]
     }, {
       "definedClassId" : "http://purl.obolibrary.org/obo/GO_0014887",
       "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0043500" ],
@@ -163768,6 +164663,16 @@
         "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009",
         "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_24867"
       } ]
+    }, {
+      "definedClassId" : "http://purl.obolibrary.org/obo/GO_0015078",
+      "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0005215" ],
+      "restrictions" : [ {
+        "propertyId" : "http://purl.obolibrary.org/obo/RO_0002342",
+        "fillerId" : "http://purl.obolibrary.org/obo/GO_0016020"
+      }, {
+        "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009",
+        "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_15378"
+      } ]
     }, {
       "definedClassId" : "http://purl.obolibrary.org/obo/GO_0015081",
       "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0022857" ],
@@ -171991,27 +172896,6 @@
         "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050",
         "fillerId" : "http://purl.obolibrary.org/obo/GO_0007600"
       } ]
-    }, {
-      "definedClassId" : "http://purl.obolibrary.org/obo/GO_0050963",
-      "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0050981" ],
-      "restrictions" : [ {
-        "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050",
-        "fillerId" : "http://purl.obolibrary.org/obo/GO_0007600"
-      } ]
-    }, {
-      "definedClassId" : "http://purl.obolibrary.org/obo/GO_0050964",
-      "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0050981" ],
-      "restrictions" : [ {
-        "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050",
-        "fillerId" : "http://purl.obolibrary.org/obo/GO_0050956"
-      } ]
-    }, {
-      "definedClassId" : "http://purl.obolibrary.org/obo/GO_0050967",
-      "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0050981" ],
-      "restrictions" : [ {
-        "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050",
-        "fillerId" : "http://purl.obolibrary.org/obo/GO_0019233"
-      } ]
     }, {
       "definedClassId" : "http://purl.obolibrary.org/obo/GO_0050968",
       "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009593" ],
@@ -178465,6 +179349,22 @@
         "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000051",
         "fillerId" : "http://purl.obolibrary.org/obo/GO_0098590"
       } ]
+    }, {
+      "definedClassId" : "http://purl.obolibrary.org/obo/GO_0120029",
+      "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006810" ],
+      "restrictions" : [ {
+        "propertyId" : "http://purl.obolibrary.org/obo/RO_0002338",
+        "fillerId" : "http://purl.obolibrary.org/obo/GO_0005829"
+      }, {
+        "propertyId" : "http://purl.obolibrary.org/obo/RO_0002339",
+        "fillerId" : "http://purl.obolibrary.org/obo/GO_0005576"
+      }, {
+        "propertyId" : "http://purl.obolibrary.org/obo/RO_0002342",
+        "fillerId" : "http://purl.obolibrary.org/obo/GO_0005886"
+      }, {
+        "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009",
+        "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_15378"
+      } ]
     }, {
       "definedClassId" : "http://purl.obolibrary.org/obo/GO_0120031",
       "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0022607" ],
@@ -180600,6 +181500,13 @@
         "propertyId" : "http://purl.obolibrary.org/obo/RO_0002339",
         "fillerId" : "http://purl.obolibrary.org/obo/GO_0005730"
       } ]
+    }, {
+      "definedClassId" : "http://purl.obolibrary.org/obo/GO_1902600",
+      "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0055085" ],
+      "restrictions" : [ {
+        "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009",
+        "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_15378"
+      } ]
     }, {
       "definedClassId" : "http://purl.obolibrary.org/obo/GO_1902679",
       "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ],
@@ -193813,13 +194720,6 @@
         "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000051",
         "fillerId" : "http://purl.obolibrary.org/obo/CL_0000067"
       } ]
-    }, {
-      "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0010521",
-      "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000062" ],
-      "restrictions" : [ {
-        "propertyId" : "http://purl.obolibrary.org/obo/RO_0002215",
-        "fillerId" : "http://purl.obolibrary.org/obo/GO_0050964"
-      } ]
     }, {
       "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0010527",
       "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002558" ],
@@ -196782,6 +197682,13 @@
         "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050",
         "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001052"
       } ]
+    }, {
+      "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_8850001",
+      "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000483" ],
+      "restrictions" : [ {
+        "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050",
+        "fillerId" : "http://purl.obolibrary.org/obo/UBERON_8410050"
+      } ]
     } ],
     "domainRangeAxioms" : [ {
       "predicateId" : "http://purl.obolibrary.org/obo/BFO_0000050",
diff --git a/empty.obo b/empty.obo
index e1387e2..e2a145a 100644
--- a/empty.obo
+++ b/empty.obo
@@ -1,5 +1,5 @@
 format-version: 1.2
-data-version: releases/2026-02-23
+data-version: releases/2026-04-04
 idspace: dce http://purl.org/dc/elements/1.1/ 
 idspace: dcterms http://purl.org/dc/terms/ 
 idspace: oboInOwl http://www.geneontology.org/formats/oboInOwl# 
@@ -10,7 +10,7 @@ ontology: empty
 property_value: dcterms:description "An ontology of experimental measurements in the sciences, the purposes for which experimental measurements were made, and experimental treatments, with a focus on life sciences." xsd:string
 property_value: dcterms:license https://creativecommons.org/licenses/by/4.0/
 property_value: dcterms:title "Experimental Measurements Purposes and Treatments ontologY" xsd:string
-property_value: owl:versionInfo "2026-02-23" xsd:string
+property_value: owl:versionInfo "2026-04-04" xsd:string
 property_value: owl:versionInfo "Release 2025-07-10" xsd:string
 
 [Term]
@@ -115,7 +115,7 @@ is_a: CHEBI:36338 ! lepton
 [Term]
 id: CHEBI:131604
 name: Mycoplasma genitalium metabolite
-def: "Any bacterial metabolite produced during a metabolic reaction in Mycoplasma genitalium." []
+def: "Any bacterial metabolite produced during a metabolic reaction in <em>Mycoplasma genitalium</em>." []
 is_a: CHEBI:76969 ! bacterial metabolite
 
 [Term]
@@ -131,11 +131,12 @@ def: "A carbohydrate acid derivative anion obtained by deprotonation of the carb
 is_a: CHEBI:61469 ! polyanionic polymer
 is_a: CHEBI:63551 ! carbohydrate acid derivative anion
 relationship: is_conjugate_base_of CHEBI:16336 ! hyaluronic acid
+relationship: RO:0018033 CHEBI:16336 ! is deprotonated form of hyaluronic acid
 
 [Term]
 id: CHEBI:136889
 name: 5beta steroid
-def: "Any steroid that has beta-configuration at position 5." []
+def: "Any steroid that has β-configuration at position 5." []
 is_a: CHEBI:35341 ! steroid
 
 [Term]
@@ -147,7 +148,7 @@ is_a: CHEBI:39141 ! Bronsted acid
 [Term]
 id: CHEBI:138366
 name: bile acids
-def: "Any member of a group of hydroxy steroids occuring in bile, where they are present as the sodium salts of their amides with glycine or taurine. In mammals bile acids almost invariably have 5beta-configuration, while in lower vertebrates, some bile acids, known as allo-bile acids, have 5alpha-configuration." []
+def: "Any member of a group of hydroxy steroids occuring in bile, where they are present as the sodium salts of their amides with glycine or taurine. In mammals bile acids almost invariably have 5β-configuration, while in lower vertebrates, some bile acids, known as <i>allo</i>-bile acids, have 5α-configuration." []
 is_a: CHEBI:25384 ! monocarboxylic acid
 is_a: CHEBI:35350 ! hydroxy steroid
 is_a: CHEBI:36078 ! cholanoid
@@ -163,29 +164,30 @@ id: CHEBI:13941
 name: carbamate
 is_a: CHEBI:37022 ! amino-acid anion
 relationship: is_conjugate_base_of CHEBI:28616 ! carbamic acid
+relationship: RO:0018033 CHEBI:28616 ! is deprotonated form of carbamic acid
 
 [Term]
 id: CHEBI:140601
 name: fatty acid 4:0
 def: "Any saturated fatty acid containing 4 carbons." []
 is_a: CHEBI:26666 ! short-chain fatty acid
-relationship: is_conjugate_acid_of CHEBI:78115 ! fatty acid anion 4:0
+relationship: RO:0018034 CHEBI:78115 ! is protonated form of fatty acid anion 4:0
 
 [Term]
 id: CHEBI:142163
 name: 24G7 epitope
-def: "An antigenic epitope recognized by an anti-bilirubin monoclonal antibody designated 24G7. A substructure of bilirubin IXalpha, it is the region containing the oxo group at C-1, the methyl group at C-2, C-(4, 5, 6, 9), and N-21 and -22." []
+def: "An antigenic epitope recognized by an anti-bilirubin monoclonal antibody designated 24G7. A substructure of bilirubin IXα, it is the region containing the oxo group at C-1, the methyl group at C-2, C-(4, 5, 6, 9), and N-21 and -22." []
 is_a: CHEBI:24433 ! group
 relationship: RO:0000087 CHEBI:53000 ! has role epitope
 
 [Term]
 id: CHEBI:14321
 name: glutamate(1-)
-def: "An alpha-amino-acid anion that is the conjugate base of glutamic acid, having anionic carboxy groups and a cationic amino group" []
+def: "An α-amino-acid anion that is the conjugate base of glutamic acid, having anionic carboxy groups and a cationic amino group" []
 is_a: CHEBI:33558 ! alpha-amino-acid anion
-relationship: is_conjugate_acid_of CHEBI:29987 ! glutamate(2-)
-relationship: is_conjugate_base_of CHEBI:18237 ! glutamic acid
 relationship: RO:0000087 CHEBI:78675 ! has role fundamental metabolite
+relationship: RO:0018033 CHEBI:18237 ! is deprotonated form of glutamic acid
+relationship: RO:0018034 CHEBI:29987 ! is protonated form of glutamate(2-)
 
 [Term]
 id: CHEBI:15339
@@ -216,6 +218,16 @@ relationship: RO:0000087 CHEBI:48356 ! has role protic solvent
 relationship: RO:0000087 CHEBI:64049 ! has role food acidity regulator
 relationship: RO:0000087 CHEBI:65256 ! has role antimicrobial food preservative
 relationship: RO:0000087 CHEBI:83056 ! has role Daphnia magna metabolite
+relationship: RO:0018034 CHEBI:30089 ! is protonated form of acetate
+
+[Term]
+id: CHEBI:15378
+name: hydron
+def: "The general name for the hydrogen nucleus, to be used without regard to the hydrogen nuclear mass (either for hydrogen in its natural abundance or where it is not desired to distinguish between the isotopes)." []
+is_a: CHEBI:25414 ! monoatomic monocation
+is_a: CHEBI:33251 ! monoatomic hydrogen
+is_a: CHEBI:33252 ! atomic nucleus
+is_a: CHEBI:60242 ! monovalent inorganic cation
 
 [Term]
 id: CHEBI:15379
@@ -231,20 +243,21 @@ relationship: RO:0000087 CHEBI:63248 ! has role oxidising agent
 relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
 relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
 relationship: RO:0000087 CHEBI:77974 ! has role food packaging gas
+relationship: RO:0018033 CHEBI:29793 ! is deprotonated form of hydridodioxygen(1+)
 
 [Term]
 id: CHEBI:15693
 name: aldose
-def: "Aldehydic parent sugars (polyhydroxy aldehydes H[CH(OH)]nC(=O)H, n >= 2) and their intramolecular hemiacetals." []
+def: "Aldehydic parent sugars (polyhydroxy aldehydes H[CH(OH)]<small><sub><em>n</em></sub></small>C(=O)H, <em>n</em> ≥ 2) and their intramolecular hemiacetals." []
 is_a: CHEBI:35381 ! monosaccharide
 
 [Term]
 id: CHEBI:15705
 name: L-alpha-amino acid
-def: "Any alpha-amino acid having L-configuration at the alpha-carbon." []
+def: "Any α-amino acid having <small>L</small>-configuration at the α-carbon." []
 is_a: CHEBI:33704 ! alpha-amino acid
-relationship: is_conjugate_acid_of CHEBI:59814 ! L-alpha-amino acid anion
-relationship: is_tautomer_of CHEBI:59869 ! L-alpha-amino acid zwitterion
+relationship: RO:0018034 CHEBI:59814 ! is protonated form of L-alpha-amino acid anion
+relationship: RO:0018036 CHEBI:59869 ! is tautomer of L-alpha-amino acid zwitterion
 
 [Term]
 id: CHEBI:15841
@@ -255,13 +268,13 @@ is_a: CHEBI:16670 ! peptide
 [Term]
 id: CHEBI:15966
 name: D-glutamic acid
-def: "An optically active form of glutamic acid having D-configuration." []
+def: "An optically active form of glutamic acid having <small>D</small>-configuration." []
 is_a: CHEBI:16733 ! D-alpha-amino acid
 is_a: CHEBI:18237 ! glutamic acid
-relationship: is_conjugate_acid_of CHEBI:29986 ! D-glutamate(1-)
-relationship: is_enantiomer_of CHEBI:16015 ! L-glutamic acid
 relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
 relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
+relationship: RO:0018034 CHEBI:29986 ! is protonated form of D-glutamate(1-)
+relationship: RO:0018039 CHEBI:16015 ! is enantiomer of L-glutamic acid
 
 [Term]
 id: CHEBI:15986
@@ -274,17 +287,17 @@ relationship: BFO:0000051 CHEBI:50319 ! has part nucleotide residue
 [Term]
 id: CHEBI:16015
 name: L-glutamic acid
-def: "An optically active form of glutamic acid having L-configuration." []
+def: "An optically active form of glutamic acid having <small>L</small>-configuration." []
 is_a: CHEBI:18237 ! glutamic acid
 is_a: CHEBI:24318 ! glutamine family amino acid
-relationship: is_conjugate_acid_of CHEBI:29985 ! L-glutamate(1-)
-relationship: is_enantiomer_of CHEBI:15966 ! D-glutamic acid
 relationship: RO:0000087 CHEBI:173085 ! has role ferroptosis inducer
 relationship: RO:0000087 CHEBI:25512 ! has role neurotransmitter
 relationship: RO:0000087 CHEBI:27027 ! has role micronutrient
 relationship: RO:0000087 CHEBI:50733 ! has role nutraceutical
 relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
 relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
+relationship: RO:0018034 CHEBI:29985 ! is protonated form of L-glutamate(1-)
+relationship: RO:0018039 CHEBI:15966 ! is enantiomer of D-glutamic acid
 
 [Term]
 id: CHEBI:16134
@@ -301,6 +314,8 @@ relationship: RO:0000087 CHEBI:59740 ! has role nucleophilic reagent
 relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
 relationship: RO:0000087 CHEBI:77941 ! has role EC 3.5.1.4 (amidase) inhibitor
 relationship: RO:0000087 CHEBI:78433 ! has role refrigerant
+relationship: RO:0018033 CHEBI:28938 ! is deprotonated form of ammonium
+relationship: RO:0018034 CHEBI:29337 ! is protonated form of azanide
 
 [Term]
 id: CHEBI:16189
@@ -313,15 +328,17 @@ relationship: is_conjugate_base_of CHEBI:45696 ! hydrogensulfate
 relationship: RO:0000087 CHEBI:23357 ! has role cofactor
 relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
 relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
+relationship: RO:0018033 CHEBI:45696 ! is deprotonated form of hydrogensulfate
 
 [Term]
 id: CHEBI:16336
 name: hyaluronic acid
-def: "A mucopolysaccharide composed of N-acetylglucosamine and glucuronic acid subunits. It is found in the connective tissues of vertebrates. A principal constituent of the extracellular matrix (ECM), it mediates the growth and metastasis of tumour cells." []
+def: "A mucopolysaccharide composed of <em>N</em>-acetylglucosamine and glucuronic acid subunits. It is found in the connective tissues of vertebrates. A principal constituent of the extracellular matrix (ECM), it mediates the growth and metastasis of tumour cells." []
 is_a: CHEBI:37395 ! mucopolysaccharide
 is_a: CHEBI:72813 ! exopolysaccharide
 relationship: is_conjugate_acid_of CHEBI:132153 ! hyaluronate
 relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
+relationship: RO:0018034 CHEBI:132153 ! is protonated form of hyaluronate
 
 [Term]
 id: CHEBI:16541
@@ -333,7 +350,7 @@ relationship: BFO:0000051 CHEBI:33700 ! has part proteinogenic amino-acid residu
 [Term]
 id: CHEBI:16646
 name: carbohydrate
-def: "Any member of the class of organooxygen compounds that is a polyhydroxy-aldehyde or -ketone or a lactol resulting from their intramolecular condensation (monosaccharides); substances derived from these by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom; and polymeric products arising by intermolecular acetal formation between two or more such molecules (disaccharides, polysaccharides and oligosaccharides). Carbohydrates contain only carbon, hydrogen and oxygen atoms; prior to any oxidation or reduction, most have the empirical formula Cm(H2O)n. Compounds obtained from carbohydrates by substitution, etc., are known as carbohydrate derivatives and may contain other elements. Cyclitols are generally not regarded as carbohydrates." []
+def: "Any member of the class of organooxygen compounds that is a polyhydroxy-aldehyde or -ketone or a lactol resulting from their intramolecular condensation (monosaccharides); substances derived from these by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom; and polymeric products arising by intermolecular acetal formation between two or more such molecules (disaccharides, polysaccharides and oligosaccharides). Carbohydrates contain only carbon, hydrogen and oxygen atoms; prior to any oxidation or reduction, most have the empirical formula C<small><sub><em>m</em></sub></small>(H<small><sub>2</sub></small>O)<small><sub><em>n</em></sub></small>. Compounds obtained from carbohydrates by substitution, etc., are known as carbohydrate derivatives and may contain other elements. Cyclitols are generally not regarded as carbohydrates." []
 is_a: CHEBI:78616 ! carbohydrates and carbohydrate derivatives
 
 [Term]
@@ -345,25 +362,27 @@ is_a: CHEBI:37622 ! carboxamide
 is_a: CHEBI:50047 ! organic amino compound
 relationship: BFO:0000051 CHEBI:33708 ! has part amino-acid residue
 relationship: is_tautomer_of CHEBI:60466 ! peptide zwitterion
+relationship: RO:0018036 CHEBI:60466 ! is tautomer of peptide zwitterion
 
 [Term]
 id: CHEBI:166902
 name: noradrenaline(1+)
+def: "An organic cation that is the conjugate acid of noradrenaline, obtained by protonation of the primary amino group; major species at pH 7.3." []
 is_a: CHEBI:25697 ! organic cation
 is_a: CHEBI:35274 ! ammonium ion derivative
-relationship: is_conjugate_acid_of CHEBI:33569 ! noradrenaline
+relationship: RO:0018034 CHEBI:33569 ! is protonated form of noradrenaline
 
 [Term]
 id: CHEBI:16733
 name: D-alpha-amino acid
 is_a: CHEBI:83925 ! non-proteinogenic alpha-amino acid
-relationship: is_conjugate_acid_of CHEBI:60895 ! D-alpha-amino acid anion
-relationship: is_tautomer_of CHEBI:59871 ! D-alpha-amino acid zwitterion
+relationship: RO:0018034 CHEBI:60895 ! is protonated form of D-alpha-amino acid anion
+relationship: RO:0018036 CHEBI:59871 ! is tautomer of D-alpha-amino acid zwitterion
 
 [Term]
 id: CHEBI:167559
 name: glycan
-def: "Any oligosaccharide, polysaccharide or their derivatives consisting of monosaccharides or monosaccharide derivatives linked by glycosidic bonds. See also http://www.ontobee.org/ontology/GNO?iri=http://purl.obolibrary.org/obo/GNO_00000001." []
+def: "Any oligosaccharide, polysaccharide or their derivatives consisting of monosaccharides or monosaccharide derivatives linked by glycosidic bonds. See also <a href=\"http://www.ontobee.org/ontology/GNO?iri=http://purl.obolibrary.org/obo/GNO_00000001\" target=\"_blank\">http://www.ontobee.org/ontology/GNO?iri=http://purl.obolibrary.org/obo/GNO_00000001</a>." []
 is_a: CHEBI:78616 ! carbohydrates and carbohydrate derivatives
 
 [Term]
@@ -378,20 +397,21 @@ relationship: is_conjugate_base_of CHEBI:57887 ! tryptaminium
 relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
 relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite
 relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
+relationship: RO:0018033 CHEBI:57887 ! is deprotonated form of tryptaminium
 
 [Term]
 id: CHEBI:16865
 name: gamma-aminobutyric acid
-def: "A gamma-amino acid that is butanoic acid with the amino substituent located at C-4." []
+def: "A γ-amino acid that is butanoic acid with the amino substituent located at C-4." []
 is_a: CHEBI:25384 ! monocarboxylic acid
 is_a: CHEBI:33707 ! gamma-amino acid
-relationship: has_functional_parent CHEBI:30772 ! butyric acid
-relationship: is_conjugate_acid_of CHEBI:30566 ! gamma-aminobutyrate
-relationship: is_tautomer_of CHEBI:59888 ! gamma-aminobutyric acid zwitterion
 relationship: RO:0000087 CHEBI:25512 ! has role neurotransmitter
 relationship: RO:0000087 CHEBI:62488 ! has role signalling molecule
 relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
 relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
+relationship: RO:0018034 CHEBI:30566 ! is protonated form of gamma-aminobutyrate
+relationship: RO:0018036 CHEBI:59888 ! is tautomer of gamma-aminobutyric acid zwitterion
+relationship: RO:0018038 CHEBI:30772 ! has functional parent butyric acid
 
 [Term]
 id: CHEBI:16990
@@ -400,15 +420,15 @@ def: "A member of the class of  biladienes that is a linear tetrapyrrole with th
 is_a: CHEBI:35692 ! dicarboxylic acid
 is_a: CHEBI:36735 ! biladienes
 relationship: BFO:0000051 CHEBI:142163 ! has part 24G7 epitope
-relationship: is_conjugate_acid_of CHEBI:57977 ! bilirubin(2-)
 relationship: RO:0000087 CHEBI:22586 ! has role antioxidant
 relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
 relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
+relationship: RO:0018034 CHEBI:57977 ! is protonated form of bilirubin(2-)
 
 [Term]
 id: CHEBI:17087
 name: ketone
-def: "A compound in which a carbonyl group is bonded to two carbon atoms: R2C=O (neither R may be H)." []
+def: "A compound in which a carbonyl group is bonded to two carbon atoms: R<small><sub>2</sub></small>C=O (neither R may be H)." []
 is_a: CHEBI:36586 ! carbonyl compound
 
 [Term]
@@ -436,25 +456,25 @@ id: CHEBI:17544
 name: hydrogencarbonate
 def: "The carbon oxoanion resulting from the removal of a proton from carbonic acid." []
 is_a: CHEBI:35604 ! carbon oxoanion
-relationship: is_conjugate_acid_of CHEBI:41609 ! carbonate
-relationship: is_conjugate_base_of CHEBI:28976 ! carbonic acid
 relationship: RO:0000087 CHEBI:23357 ! has role cofactor
 relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
 relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
 relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
 relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
+relationship: RO:0018033 CHEBI:28976 ! is deprotonated form of carbonic acid
+relationship: RO:0018034 CHEBI:41609 ! is protonated form of carbonate
 
 [Term]
 id: CHEBI:17608
 name: D-aldohexose
-def: "Any D-aldose having a chain of six carbon atoms in the molecule." []
+def: "Any <small>D</small>-aldose having a chain of six carbon atoms in the molecule." []
 is_a: CHEBI:33917 ! aldohexose
 is_a: CHEBI:4194 ! D-hexose
 
 [Term]
 id: CHEBI:17634
 name: D-glucose
-def: "A glucose with D-configuration." []
+def: "A glucose with <small>D</small>-configuration." []
 is_a: CHEBI:17234 ! glucose
 is_a: CHEBI:17608 ! D-aldohexose
 
@@ -475,9 +495,9 @@ id: CHEBI:17968
 name: butyrate
 def: "A short-chain fatty acid anion that is the conjugate base of butyric acid, obtained by deprotonation of the carboxy group." []
 is_a: CHEBI:78115 ! fatty acid anion 4:0
-relationship: is_conjugate_base_of CHEBI:30772 ! butyric acid
 relationship: RO:0000087 CHEBI:61115 ! has role EC 3.5.1.98 (histone deacetylase) inhibitor
 relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
+relationship: RO:0018033 CHEBI:30772 ! is deprotonated form of butyric acid
 
 [Term]
 id: CHEBI:18059
@@ -508,12 +528,12 @@ is_a: CHEBI:33694 ! biomacromolecule
 [Term]
 id: CHEBI:18237
 name: glutamic acid
-def: "An alpha-amino acid that is glutaric acid bearing a single amino substituent at position 2." []
+def: "An α-amino acid that is glutaric acid bearing a single amino substituent at position 2." []
 is_a: CHEBI:26167 ! polar amino acid
 is_a: CHEBI:33704 ! alpha-amino acid
 relationship: BFO:0000051 CHEBI:50329 ! has part 2-carboxyethyl group
-relationship: is_conjugate_acid_of CHEBI:14321 ! glutamate(1-)
 relationship: RO:0000087 CHEBI:78675 ! has role fundamental metabolite
+relationship: RO:0018034 CHEBI:14321 ! is protonated form of glutamate(1-)
 
 [Term]
 id: CHEBI:18282
@@ -524,15 +544,15 @@ is_a: CHEBI:38101 ! organonitrogen heterocyclic compound
 [Term]
 id: CHEBI:18357
 name: (R)-noradrenaline
-def: "The R-enantiomer of noradrenaline." []
+def: "The <i>R</i>-enantiomer of noradrenaline." []
 is_a: CHEBI:33569 ! noradrenaline
-relationship: is_conjugate_base_of CHEBI:72587 ! (R)-noradrenaline(1+)
-relationship: is_enantiomer_of CHEBI:33571 ! (S)-noradrenaline
 relationship: RO:0000087 CHEBI:25512 ! has role neurotransmitter
 relationship: RO:0000087 CHEBI:35524 ! has role sympathomimetic agent
 relationship: RO:0000087 CHEBI:35569 ! has role alpha-adrenergic agonist
 relationship: RO:0000087 CHEBI:50514 ! has role vasoconstrictor agent
 relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
+relationship: RO:0018033 CHEBI:72587 ! is deprotonated form of (R)-noradrenaline(1+)
+relationship: RO:0018039 CHEBI:33571 ! is enantiomer of (S)-noradrenaline
 
 [Term]
 id: CHEBI:20664
@@ -542,7 +562,7 @@ is_a: CHEBI:35519 ! cholane
 [Term]
 id: CHEBI:22221
 name: acyl group
-def: "An organic group formed by removing one or more hydroxy groups from an oxoacid that has the general structure RkE(=O)l(OH)m (l =/= 0). Although the term is almost always applied to organic compounds, with carboxylic acid as the oxoacid, acyl groups can in principle be derived from other types of acids such as sulfonic acids or phosphonic acids." []
+def: "An organic group formed by removing one or more hydroxy groups from an oxoacid that has the general structure R<small><sub><em>k</em></sub></small>E(=O)<small><sub><em>l</em></sub></small>(OH)<small><sub><em>m</em></sub></small> (<em>l</em> ≠ 0). Although the term is almost always applied to organic compounds, with carboxylic acid as the oxoacid, acyl groups can in principle be derived from other types of acids such as sulfonic acids or phosphonic acids." []
 is_a: CHEBI:33247 ! organic group
 
 [Term]
@@ -610,6 +630,7 @@ name: carbamoyl group
 def: "The univalent carboacyl group formed by loss of -OH from the carboxy group of carbamic acid." []
 is_a: CHEBI:27207 ! univalent carboacyl group
 relationship: is_substituent_group_from CHEBI:28616 ! carbamic acid
+relationship: RO:0018037 CHEBI:28616 ! is substitutent group from carbamic acid
 
 [Term]
 id: CHEBI:23019
@@ -628,6 +649,14 @@ name: molecular entity
 def: "Any constitutionally or isotopically distinct atom, molecule, ion, ion pair, radical, radical ion, complex, conformer etc., identifiable as a separately distinguishable entity." []
 is_a: CHEBI:24431 ! chemical entity
 
+[Term]
+id: CHEBI:234420
+name: (S)-noradrenaline(1+)
+def: "An organic cation that is the conjugate acid of (<i>S</i>)-noradrenaline, obtained by protonation of the primary amino group; major species at pH 7.3." []
+is_a: CHEBI:166902 ! noradrenaline(1+)
+relationship: RO:0018034 CHEBI:33571 ! is protonated form of (S)-noradrenaline
+relationship: RO:0018039 CHEBI:72587 ! is enantiomer of (R)-noradrenaline(1+)
+
 [Term]
 id: CHEBI:23449
 name: cyclic peptide
@@ -655,14 +684,14 @@ is_a: CHEBI:52206 ! biochemical role
 [Term]
 id: CHEBI:24318
 name: glutamine family amino acid
-def: "An L-alpha-amino acid which is L-glutamic acid or any of the essential amino acids biosynthesised from it (glutamine, proline and arginine). A closed class." []
+def: "An <small>L</small>-α-amino acid which is <small>L</small>-glutamic acid or any of the essential amino acids biosynthesised from it (glutamine, proline and arginine). A closed class." []
 is_a: CHEBI:15705 ! L-alpha-amino acid
 is_a: CHEBI:83813 ! proteinogenic amino acid
 
 [Term]
 id: CHEBI:24319
 name: EC 6.3.1.2 (glutamate--ammonia ligase) inhibitor
-def: "An EC 6.3.* (C-N bond-forming ligase) inhibitor that interferes with the action of glutamate--ammonia ligase (EC 6.3.1.2)." []
+def: "An EC 6.3.* (<em>C</em>‒<em>N</em> bond-forming ligase) inhibitor that interferes with the action of glutamate—ammonia ligase (EC 6.3.1.2)." []
 is_a: CHEBI:76823 ! EC 6.3.1.* (acid-ammonia/amine ligase) inhibitor
 
 [Term]
@@ -714,7 +743,8 @@ is_a: CHEBI:48705 ! agonist
 id: CHEBI:24636
 name: proton
 def: "Nuclear particle of charge number +1, spin 1/2 and rest mass of 1.007276470(12) u." []
-is_a: CHEBI:36342 ! subatomic particle
+is_a: CHEBI:15378 ! hydron
+is_a: CHEBI:33253 ! nucleon
 is_a: COB:0000013 ! molecule
 
 [Term]
@@ -729,10 +759,10 @@ relationship: BFO:0000051 CHEBI:43176 ! has part hydroxy group
 [Term]
 id: CHEBI:24663
 name: hydroxy-5beta-cholanic acid
-def: "Any member of the class of 5beta-cholanic acids carrying at least one hydroxy group at unspecified position." []
+def: "Any member of the class of 5β-cholanic acids carrying at least one hydroxy group at unspecified position." []
 is_a: CHEBI:33822 ! organic hydroxy compound
 is_a: CHEBI:36248 ! 5beta-cholanic acids
-relationship: has_functional_parent CHEBI:36238 ! 5beta-cholanic acid
+relationship: RO:0018038 CHEBI:36238 ! has functional parent 5beta-cholanic acid
 
 [Term]
 id: CHEBI:24828
@@ -771,7 +801,6 @@ name: salt
 def: "A salt is an assembly of cations and anions." []
 is_a: CHEBI:37577 ! heteroatomic molecular entity
 relationship: BFO:0000051 CHEBI:22563 ! has part anion
-relationship: BFO:0000051 CHEBI:36916 ! has part cation
 
 [Term]
 id: CHEBI:24867
@@ -833,6 +862,7 @@ name: monocarboxylic acid
 def: "An oxoacid containing a single carboxy group." []
 is_a: CHEBI:33575 ! carboxylic acid
 relationship: is_conjugate_acid_of CHEBI:35757 ! monocarboxylic acid anion
+relationship: RO:0018034 CHEBI:35757 ! is protonated form of monocarboxylic acid anion
 
 [Term]
 id: CHEBI:25414
@@ -883,6 +913,7 @@ name: organic sulfate
 def: "Compounds of the general formula SO3HOR where R is an organyl group" []
 is_a: CHEBI:26820 ! sulfates
 relationship: is_conjugate_acid_of CHEBI:58958 ! organosulfate oxoanion
+relationship: RO:0018034 CHEBI:58958 ! is protonated form of organosulfate oxoanion
 
 [Term]
 id: CHEBI:25741
@@ -916,7 +947,7 @@ id: CHEBI:26167
 name: polar amino acid
 def: "Any amino acid whose side chain is capable of forming one or more hydrogen bonds." []
 is_a: CHEBI:33709 ! amino acid
-relationship: is_tautomer_of CHEBI:62031 ! polar amino acid zwitterion
+relationship: RO:0018036 CHEBI:62031 ! is tautomer of polar amino acid zwitterion
 
 [Term]
 id: CHEBI:26607
@@ -927,9 +958,9 @@ is_a: CHEBI:35366 ! fatty acid
 [Term]
 id: CHEBI:26666
 name: short-chain fatty acid
-def: "An aliphatic monocarboxylic acid with a chain length of less than C6. If any non-hydrocarbon substituent is present, the compound is not normally regarded as a short-chain fatty acid." []
+def: "An aliphatic monocarboxylic acid with a chain length of less than C<small><sub>6</sub></small>. If any non-hydrocarbon substituent is present, the compound is not normally regarded as a short-chain fatty acid." []
 is_a: CHEBI:35366 ! fatty acid
-relationship: is_conjugate_acid_of CHEBI:58951 ! short-chain fatty acid anion
+relationship: RO:0018034 CHEBI:58951 ! is protonated form of short-chain fatty acid anion
 
 [Term]
 id: CHEBI:26708
@@ -992,6 +1023,7 @@ def: "A sulfur oxoacid that consists of two oxo and two hydroxy groups joined co
 is_a: CHEBI:33402 ! sulfur oxoacid
 relationship: is_conjugate_acid_of CHEBI:45696 ! hydrogensulfate
 relationship: RO:0000087 CHEBI:35223 ! has role catalyst
+relationship: RO:0018034 CHEBI:45696 ! is protonated form of hydrogensulfate
 
 [Term]
 id: CHEBI:26932
@@ -1040,7 +1072,7 @@ relationship: RO:0000087 CHEBI:33937 ! has role macronutrient
 [Term]
 id: CHEBI:28087
 name: glycogen
-def: "A polydisperse, highly branched glucan composed of chains of D-glucopyranose residues in alpha(1->4) glycosidic linkage, joined together by alpha(1->6) glycosidic linkages. A small number of alpha(1->3) glycosidic linkages and some cumulative alpha(1->6) links also may occur. The branches in glycogen typically contain 8 to 12 glucose residues." []
+def: "A polydisperse, highly branched glucan composed of chains of <small>D</small>-glucopyranose residues in α(1→4) glycosidic linkage, joined together by α(1→6) glycosidic linkages. A small number of α(1→3) glycosidic linkages and some cumulative α(1→6) links also may occur. The branches in glycogen typically contain 8 to 12 glucose residues." []
 is_a: CHEBI:24384 ! glycogens
 relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
 relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
@@ -1054,6 +1086,7 @@ is_a: CHEBI:35605 ! carbon oxoacid
 is_a: CHEBI:64708 ! one-carbon compound
 relationship: is_conjugate_acid_of CHEBI:13941 ! carbamate
 relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
+relationship: RO:0018034 CHEBI:13941 ! is protonated form of carbamate
 
 [Term]
 id: CHEBI:28790
@@ -1069,6 +1102,8 @@ relationship: is_conjugate_base_of CHEBI:350546 ! serotonin(1+)
 relationship: RO:0000087 CHEBI:25512 ! has role neurotransmitter
 relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
 relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
+relationship: RO:0018033 CHEBI:350546 ! is deprotonated form of serotonin(1+)
+relationship: RO:0018038 CHEBI:16765 ! has functional parent tryptamine
 
 [Term]
 id: CHEBI:28868
@@ -1076,7 +1111,7 @@ name: fatty acid anion
 def: "The conjugate base of a fatty acid, arising from deprotonation of the carboxylic acid group of the corresponding fatty acid." []
 is_a: CHEBI:18059 ! lipid
 is_a: CHEBI:35757 ! monocarboxylic acid anion
-relationship: is_conjugate_base_of CHEBI:35366 ! fatty acid
+relationship: RO:0018033 CHEBI:35366 ! is deprotonated form of fatty acid
 
 [Term]
 id: CHEBI:28938
@@ -1090,6 +1125,7 @@ relationship: RO:0000087 CHEBI:23357 ! has role cofactor
 relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
 relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
 relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
+relationship: RO:0018034 CHEBI:16134 ! is protonated form of ammonia
 
 [Term]
 id: CHEBI:28965
@@ -1103,8 +1139,8 @@ id: CHEBI:28976
 name: carbonic acid
 is_a: CHEBI:35605 ! carbon oxoacid
 is_a: CHEBI:36961 ! chalcocarbonic acid
-relationship: is_conjugate_acid_of CHEBI:17544 ! hydrogencarbonate
 relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
+relationship: RO:0018034 CHEBI:17544 ! is protonated form of hydrogencarbonate
 
 [Term]
 id: CHEBI:29067
@@ -1113,6 +1149,7 @@ def: "The conjugate base formed when the carboxy group of a carboxylic acid is d
 is_a: CHEBI:25696 ! organic anion
 is_a: CHEBI:35406 ! oxoanion
 relationship: is_conjugate_base_of CHEBI:33575 ! carboxylic acid
+relationship: RO:0018033 CHEBI:33575 ! is deprotonated form of carboxylic acid
 
 [Term]
 id: CHEBI:29101
@@ -1132,6 +1169,8 @@ is_a: CHEBI:35106 ! nitrogen hydride
 is_a: CHEBI:79389 ! monovalent inorganic anion
 relationship: is_conjugate_acid_of CHEBI:29340 ! hydridonitrate(2-)
 relationship: is_conjugate_base_of CHEBI:16134 ! ammonia
+relationship: RO:0018033 CHEBI:16134 ! is deprotonated form of ammonia
+relationship: RO:0018034 CHEBI:29340 ! is protonated form of hydridonitrate(2-)
 
 [Term]
 id: CHEBI:29340
@@ -1140,57 +1179,59 @@ def: "A divalent inorganic anion resulting from the removal of two protons from
 is_a: CHEBI:35106 ! nitrogen hydride
 is_a: CHEBI:79388 ! divalent inorganic anion
 relationship: is_conjugate_base_of CHEBI:29337 ! azanide
+relationship: RO:0018033 CHEBI:29337 ! is deprotonated form of azanide
 
 [Term]
 id: CHEBI:29793
 name: hydridodioxygen(1+)
 is_a: CHEBI:33693 ! oxygen hydride
 relationship: is_conjugate_acid_of CHEBI:15379 ! dioxygen
+relationship: RO:0018034 CHEBI:15379 ! is protonated form of dioxygen
 
 [Term]
 id: CHEBI:29985
 name: L-glutamate(1-)
-def: "An alpha-amino-acid anion that is the conjugate base of L-glutamic acid, having anionic carboxy groups and a cationic amino group" []
+def: "An α-amino-acid anion that is the conjugate base of <small>L</small>-glutamic acid, having anionic carboxy groups and a cationic amino group" []
 is_a: CHEBI:14321 ! glutamate(1-)
-relationship: is_conjugate_acid_of CHEBI:29988 ! L-glutamate(2-)
-relationship: is_conjugate_base_of CHEBI:16015 ! L-glutamic acid
-relationship: is_enantiomer_of CHEBI:29986 ! D-glutamate(1-)
 relationship: RO:0000087 CHEBI:24319 ! has role EC 6.3.1.2 (glutamate--ammonia ligase) inhibitor
 relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
 relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
+relationship: RO:0018033 CHEBI:16015 ! is deprotonated form of L-glutamic acid
+relationship: RO:0018034 CHEBI:29988 ! is protonated form of L-glutamate(2-)
+relationship: RO:0018039 CHEBI:29986 ! is enantiomer of D-glutamate(1-)
 
 [Term]
 id: CHEBI:29986
 name: D-glutamate(1-)
-def: "An alpha-amino-acid anion that is the conjugate base of D-glutamic acid, having anionic carboxy groups and a cationic amino group" []
+def: "An α-amino-acid anion that is the conjugate base of <small>D</small>-glutamic acid, having anionic carboxy groups and a cationic amino group" []
 is_a: CHEBI:14321 ! glutamate(1-)
-relationship: is_conjugate_acid_of CHEBI:29989 ! D-glutamate(2-)
-relationship: is_conjugate_base_of CHEBI:15966 ! D-glutamic acid
-relationship: is_enantiomer_of CHEBI:29985 ! L-glutamate(1-)
+relationship: RO:0018033 CHEBI:15966 ! is deprotonated form of D-glutamic acid
+relationship: RO:0018034 CHEBI:29989 ! is protonated form of D-glutamate(2-)
+relationship: RO:0018039 CHEBI:29985 ! is enantiomer of L-glutamate(1-)
 
 [Term]
 id: CHEBI:29987
 name: glutamate(2-)
-def: "A dicarboxylic acid dianion that is the conjugate base of glutamate(1-)." []
+def: "A dicarboxylic acid dianion that is the conjugate base of glutamate(1−)." []
 is_a: CHEBI:28965 ! dicarboxylic acid dianion
-relationship: is_conjugate_base_of CHEBI:14321 ! glutamate(1-)
 relationship: RO:0000087 CHEBI:78675 ! has role fundamental metabolite
+relationship: RO:0018033 CHEBI:14321 ! is deprotonated form of glutamate(1-)
 
 [Term]
 id: CHEBI:29988
 name: L-glutamate(2-)
-def: "An L-alpha-amino acid anion that is the dianion obtained by the deprotonation of the both the carboxy groups of L-glutamic acid." []
+def: "An <small>L</small>-α-amino acid anion that is the dianion obtained by the deprotonation of the both the carboxy groups of <small>L</small>-glutamic acid." []
 is_a: CHEBI:29987 ! glutamate(2-)
 is_a: CHEBI:59814 ! L-alpha-amino acid anion
-relationship: is_conjugate_base_of CHEBI:29985 ! L-glutamate(1-)
-relationship: is_enantiomer_of CHEBI:29989 ! D-glutamate(2-)
+relationship: RO:0018033 CHEBI:29985 ! is deprotonated form of L-glutamate(1-)
+relationship: RO:0018039 CHEBI:29989 ! is enantiomer of D-glutamate(2-)
 
 [Term]
 id: CHEBI:29989
 name: D-glutamate(2-)
 is_a: CHEBI:29987 ! glutamate(2-)
-relationship: is_conjugate_base_of CHEBI:29986 ! D-glutamate(1-)
-relationship: is_enantiomer_of CHEBI:29988 ! L-glutamate(2-)
+relationship: RO:0018033 CHEBI:29986 ! is deprotonated form of D-glutamate(1-)
+relationship: RO:0018039 CHEBI:29988 ! is enantiomer of L-glutamate(2-)
 
 [Term]
 id: CHEBI:30089
@@ -1200,21 +1241,22 @@ is_a: CHEBI:35757 ! monocarboxylic acid anion
 relationship: is_conjugate_base_of CHEBI:15366 ! acetic acid
 relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
 relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
+relationship: RO:0018033 CHEBI:15366 ! is deprotonated form of acetic acid
 
 [Term]
 id: CHEBI:30212
 name: photon
-def: "Particle of zero charge, zero rest mass, spin quantum number 1, energy hnu and momentum hnu/c (h is the Planck constant, nu the frequency of radiation and c the speed of light), carrier of electromagnetic force." []
+def: "Particle of zero charge, zero rest mass, spin quantum number 1, energy <em>h</em><em>ν</em> and momentum <em>h</em><em>ν</em>/<em>c</em> (<em>h</em> is the Planck constant, <em>ν</em> the frequency of radiation and <em>c</em> the speed of light), carrier of electromagnetic force." []
 is_a: CHEBI:36341 ! boson
 
 [Term]
 id: CHEBI:30566
 name: gamma-aminobutyrate
-def: "An gamma-amino acid anion resulting from the deprotonation of the carboxy group of gamma-aminobutyric acid." []
+def: "An γ-amino acid anion resulting from the deprotonation of the carboxy group of γ-aminobutyric acid." []
 is_a: CHEBI:71666 ! gamma-amino acid anion
-relationship: has_functional_parent CHEBI:17968 ! butyrate
-relationship: is_conjugate_base_of CHEBI:16865 ! gamma-aminobutyric acid
 relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
+relationship: RO:0018033 CHEBI:16865 ! is deprotonated form of gamma-aminobutyric acid
+relationship: RO:0018038 CHEBI:17968 ! has functional parent butyrate
 
 [Term]
 id: CHEBI:30772
@@ -1222,14 +1264,14 @@ name: butyric acid
 def: "A straight-chain saturated fatty acid that is butane in which one of the terminal methyl groups has been oxidised to a carboxy group." []
 is_a: CHEBI:140601 ! fatty acid 4:0
 is_a: CHEBI:39418 ! straight-chain saturated fatty acid
-relationship: is_conjugate_acid_of CHEBI:17968 ! butyrate
 relationship: RO:0000087 CHEBI:131604 ! has role Mycoplasma genitalium metabolite
 relationship: RO:0000087 CHEBI:84087 ! has role human urinary metabolite
+relationship: RO:0018034 CHEBI:17968 ! is protonated form of butyrate
 
 [Term]
 id: CHEBI:3098
 name: bile acid
-def: "Any member of a group of hydroxy-5beta-cholanic acids occuring in bile, where they are present as the sodium salts of their amides with glycine or taurine. In mammals bile acids almost invariably have 5beta-configuration." []
+def: "Any member of a group of hydroxy-5β-cholanic acids occuring in bile, where they are present as the sodium salts of their amides with glycine or taurine. In mammals bile acids almost invariably have 5β-configuration." []
 is_a: CHEBI:138366 ! bile acids
 is_a: CHEBI:24663 ! hydroxy-5beta-cholanic acid
 
@@ -1242,7 +1284,7 @@ is_a: CHEBI:50047 ! organic amino compound
 [Term]
 id: CHEBI:32988
 name: amide
-def: "An amide is a derivative of an oxoacid RkE(=O)l(OH)m (l =/= 0) in which an acidic hydroxy group has been replaced by an amino or substituted amino group." []
+def: "An amide is a derivative of an oxoacid R<small><sub><em>k</em></sub></small>E(=O)<small><sub><em>l</em></sub></small>(OH)<small><sub><em>m</em></sub></small> (<em>l</em> ≠ 0) in which an acidic hydroxy group has been replaced by an amino or substituted amino group." []
 is_a: CHEBI:51143 ! nitrogen molecular entity
 
 [Term]
@@ -1268,6 +1310,7 @@ id: CHEBI:33241
 name: oxoacid derivative
 is_a: CHEBI:37577 ! heteroatomic molecular entity
 relationship: has_functional_parent CHEBI:24833 ! oxoacid
+relationship: RO:0018038 CHEBI:24833 ! has functional parent oxoacid
 
 [Term]
 id: CHEBI:33242
@@ -1295,6 +1338,8 @@ def: "Any substituent group or skeleton containing carbon." []
 is_a: CHEBI:24433 ! group
 relationship: is_conjugate_acid_of CHEBI:64775 ! organic anionic group
 relationship: is_conjugate_base_of CHEBI:64769 ! organic cationic group
+relationship: RO:0018033 CHEBI:64769 ! is deprotonated form of organic cationic group
+relationship: RO:0018034 CHEBI:64775 ! is protonated form of organic anionic group
 
 [Term]
 id: CHEBI:33249
@@ -1307,9 +1352,14 @@ id: CHEBI:33250
 name: atom
 def: "A chemical entity constituting the smallest component of an element having the chemical properties of the element." []
 is_a: CHEBI:24431 ! chemical entity
-relationship: BFO:0000051 CHEBI:10545 ! has part electron
 relationship: BFO:0000051 CHEBI:33252 ! has part atomic nucleus
 
+[Term]
+id: CHEBI:33251
+name: monoatomic hydrogen
+is_a: CHEBI:33238 ! monoatomic entity
+is_a: CHEBI:33260 ! elemental hydrogen
+
 [Term]
 id: CHEBI:33252
 name: atomic nucleus
@@ -1327,7 +1377,7 @@ is_a: CHEBI:36347 ! nuclear particle
 [Term]
 id: CHEBI:33256
 name: primary amide
-def: "A derivative of an oxoacid RkE(=O)l(OH)m (l =/= 0) in which an acidic hydroxy group has been replaced by an amino or substituted amino group." []
+def: "A derivative of an oxoacid R<small><sub><em>k</em></sub></small>E(=O)<small><sub><em>l</em></sub></small>(OH)<small><sub><em>m</em></sub></small> (<em>l</em> ≠ 0) in which an acidic hydroxy group has been replaced by an amino or substituted amino group." []
 is_a: CHEBI:32988 ! amide
 
 [Term]
@@ -1336,6 +1386,13 @@ name: elemental molecular entity
 def: "A molecular entity all atoms of which have the same atomic number." []
 is_a: CHEBI:23367 ! molecular entity
 
+[Term]
+id: CHEBI:33260
+name: elemental hydrogen
+is_a: CHEBI:24835 ! inorganic molecular entity
+is_a: CHEBI:33259 ! elemental molecular entity
+is_a: CHEBI:33608 ! hydrogen molecular entity
+
 [Term]
 id: CHEBI:33262
 name: elemental oxygen
@@ -1475,6 +1532,7 @@ name: alpha-amino-acid anion
 def: "An amino-acid anion obtained by deprotonation of any alpha-amino acid." []
 is_a: CHEBI:37022 ! amino-acid anion
 relationship: is_conjugate_base_of CHEBI:33704 ! alpha-amino acid
+relationship: RO:0018033 CHEBI:33704 ! is deprotonated form of alpha-amino acid
 
 [Term]
 id: CHEBI:33559
@@ -1490,7 +1548,7 @@ is_a: CHEBI:33318 ! main group element atom
 [Term]
 id: CHEBI:33566
 name: catechols
-def: "Any compound containing an o-diphenol component." []
+def: "Any compound containing an <em>o</em>-diphenol component." []
 is_a: CHEBI:33570 ! benzenediols
 
 [Term]
@@ -1505,8 +1563,8 @@ id: CHEBI:33569
 name: noradrenaline
 def: "A catecholamine in which C-1 of the aminoethyl side-chain is hydroxy-substituted." []
 is_a: CHEBI:33567 ! catecholamine
-relationship: is_conjugate_base_of CHEBI:166902 ! noradrenaline(1+)
 relationship: RO:0000087 CHEBI:76967 ! has role human xenobiotic metabolite
+relationship: RO:0018033 CHEBI:166902 ! is deprotonated form of noradrenaline(1+)
 
 [Term]
 id: CHEBI:33570
@@ -1516,9 +1574,10 @@ is_a: CHEBI:33853 ! phenols
 [Term]
 id: CHEBI:33571
 name: (S)-noradrenaline
-def: "The S-enantiomer of noradrenaline." []
+def: "The <i>S</i>-enantiomer of noradrenaline." []
 is_a: CHEBI:33569 ! noradrenaline
-relationship: is_enantiomer_of CHEBI:18357 ! (R)-noradrenaline
+relationship: RO:0018033 CHEBI:234420 ! is deprotonated form of (S)-noradrenaline(1+)
+relationship: RO:0018039 CHEBI:18357 ! is enantiomer of (R)-noradrenaline
 
 [Term]
 id: CHEBI:33575
@@ -1529,6 +1588,7 @@ is_a: CHEBI:36586 ! carbonyl compound
 is_a: CHEBI:64709 ! organic acid
 relationship: BFO:0000051 CHEBI:46883 ! has part carboxy group
 relationship: is_conjugate_acid_of CHEBI:29067 ! carboxylic acid anion
+relationship: RO:0018034 CHEBI:29067 ! is protonated form of carboxylic acid anion
 
 [Term]
 id: CHEBI:33579
@@ -1553,7 +1613,6 @@ is_a: CHEBI:25367 ! molecule
 id: CHEBI:33608
 name: hydrogen molecular entity
 is_a: CHEBI:33674 ! s-block molecular entity
-relationship: BFO:0000051 CHEBI:49637 ! has part hydrogen atom
 
 [Term]
 id: CHEBI:33635
@@ -1597,7 +1656,6 @@ id: CHEBI:33674
 name: s-block molecular entity
 def: "An s-block molecular entity is a molecular entity containing one or more atoms of an s-block element." []
 is_a: CHEBI:33579 ! main group molecular entity
-relationship: BFO:0000051 CHEBI:33559 ! has part s-block element atom
 
 [Term]
 id: CHEBI:33675
@@ -1633,7 +1691,7 @@ is_a: CHEBI:33694 ! biomacromolecule
 [Term]
 id: CHEBI:33696
 name: nucleic acid
-def: "A macromolecule made up of nucleotide units and hydrolysable into certain pyrimidine or purine bases (usually adenine, cytosine, guanine, thymine, uracil), D-ribose or 2-deoxy-D-ribose and phosphoric acid." []
+def: "A macromolecule made up of nucleotide units and hydrolysable into certain pyrimidine or purine bases (usually adenine, cytosine, guanine, thymine, uracil), <small>D</small>-ribose or 2-deoxy-<small>D</small>-ribose and phosphoric acid." []
 is_a: CHEBI:15986 ! polynucleotide
 relationship: BFO:0000051 CHEBI:33791 ! has part canonical nucleoside residue
 relationship: BFO:0000051 CHEBI:50297 ! has part canonical nucleotide residue
@@ -1664,6 +1722,7 @@ name: amino-acid cation
 is_a: CHEBI:25697 ! organic cation
 is_a: CHEBI:33702 ! polyatomic cation
 relationship: is_conjugate_acid_of CHEBI:33709 ! amino acid
+relationship: RO:0018034 CHEBI:33709 ! is protonated form of amino acid
 
 [Term]
 id: CHEBI:33704
@@ -1673,13 +1732,16 @@ is_a: CHEBI:33709 ! amino acid
 relationship: is_conjugate_acid_of CHEBI:33558 ! alpha-amino-acid anion
 relationship: is_conjugate_base_of CHEBI:33719 ! alpha-amino-acid cation
 relationship: is_tautomer_of CHEBI:78608 ! alpha-amino-acid zwitterion
+relationship: RO:0018033 CHEBI:33719 ! is deprotonated form of alpha-amino-acid cation
+relationship: RO:0018034 CHEBI:33558 ! is protonated form of alpha-amino-acid anion
+relationship: RO:0018036 CHEBI:78608 ! is tautomer of alpha-amino-acid zwitterion
 
 [Term]
 id: CHEBI:33707
 name: gamma-amino acid
-def: "A non-proteinogenic amino-acid in which the amino group is located on the carbon atom at the position gamma to the carboxy group." []
+def: "A non-proteinogenic amino-acid in which the amino group is located on the carbon atom at the position γ to the carboxy group." []
 is_a: CHEBI:83820 ! non-proteinogenic amino acid
-relationship: is_conjugate_acid_of CHEBI:71666 ! gamma-amino acid anion
+relationship: RO:0018034 CHEBI:71666 ! is protonated form of gamma-amino acid anion
 
 [Term]
 id: CHEBI:33708
@@ -1689,6 +1751,9 @@ is_a: CHEBI:33247 ! organic group
 relationship: is_conjugate_acid_of CHEBI:64898 ! anionic amino-acid residue
 relationship: is_conjugate_base_of CHEBI:58942 ! cationic amino-acid residue
 relationship: is_substituent_group_from CHEBI:33709 ! amino acid
+relationship: RO:0018033 CHEBI:58942 ! is deprotonated form of cationic amino-acid residue
+relationship: RO:0018034 CHEBI:64898 ! is protonated form of anionic amino-acid residue
+relationship: RO:0018037 CHEBI:33709 ! is substitutent group from amino acid
 
 [Term]
 id: CHEBI:33709
@@ -1698,6 +1763,8 @@ is_a: CHEBI:33575 ! carboxylic acid
 is_a: CHEBI:50047 ! organic amino compound
 relationship: is_conjugate_acid_of CHEBI:37022 ! amino-acid anion
 relationship: is_conjugate_base_of CHEBI:33703 ! amino-acid cation
+relationship: RO:0018033 CHEBI:33703 ! is deprotonated form of amino-acid cation
+relationship: RO:0018034 CHEBI:37022 ! is protonated form of amino-acid anion
 
 [Term]
 id: CHEBI:33710
@@ -1705,12 +1772,14 @@ name: alpha-amino-acid residue
 def: "An amino-acid residue derived from an alpha-amino acid." []
 is_a: CHEBI:33708 ! amino-acid residue
 relationship: is_substituent_group_from CHEBI:33704 ! alpha-amino acid
+relationship: RO:0018037 CHEBI:33704 ! is substitutent group from alpha-amino acid
 
 [Term]
 id: CHEBI:33719
 name: alpha-amino-acid cation
 is_a: CHEBI:33703 ! amino-acid cation
 relationship: is_conjugate_acid_of CHEBI:33704 ! alpha-amino acid
+relationship: RO:0018034 CHEBI:33704 ! is protonated form of alpha-amino acid
 
 [Term]
 id: CHEBI:33720
@@ -1718,12 +1787,14 @@ name: carbohydrate acid
 is_a: CHEBI:16646 ! carbohydrate
 is_a: CHEBI:33575 ! carboxylic acid
 relationship: is_conjugate_acid_of CHEBI:33721 ! carbohydrate acid anion
+relationship: RO:0018034 CHEBI:33721 ! is protonated form of carbohydrate acid anion
 
 [Term]
 id: CHEBI:33721
 name: carbohydrate acid anion
 is_a: CHEBI:29067 ! carboxylic acid anion
 relationship: is_conjugate_base_of CHEBI:33720 ! carbohydrate acid
+relationship: RO:0018033 CHEBI:33720 ! is deprotonated form of carbohydrate acid
 
 [Term]
 id: CHEBI:33791
@@ -1804,6 +1875,7 @@ def: "An ammonium ion that is the conjugate acid of serotonin; major species at
 is_a: CHEBI:35274 ! ammonium ion derivative
 relationship: is_conjugate_acid_of CHEBI:28790 ! serotonin
 relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
+relationship: RO:0018034 CHEBI:28790 ! is protonated form of serotonin
 
 [Term]
 id: CHEBI:35106
@@ -1814,7 +1886,7 @@ is_a: CHEBI:51143 ! nitrogen molecular entity
 [Term]
 id: CHEBI:35107
 name: azane
-def: "Saturated acyclic nitrogen hydrides having the general formula NnHn+2." []
+def: "Saturated acyclic nitrogen hydrides having the general formula N<small><sub><em>n</em></sub></small>H<small><sub><em>n</em>+2</sub></small>." []
 is_a: CHEBI:35106 ! nitrogen hydride
 
 [Term]
@@ -1849,6 +1921,7 @@ def: "A derivative of ammonium, NH4(+), in which one (or more) of the hydrogens
 is_a: CHEBI:33702 ! polyatomic cation
 is_a: CHEBI:51143 ! nitrogen molecular entity
 relationship: has_parent_hydride CHEBI:28938 ! ammonium
+relationship: RO:0018040 CHEBI:28938 ! has parent hydride ammonium
 
 [Term]
 id: CHEBI:35287
@@ -1859,7 +1932,7 @@ is_a: CHEBI:35267 ! quaternary ammonium ion
 [Term]
 id: CHEBI:35341
 name: steroid
-def: "Any of naturally occurring compounds and synthetic analogues, based on the cyclopenta[a]phenanthrene carbon skeleton, partially or completely hydrogenated; there are usually methyl groups at C-10 and C-13, and often an alkyl group at C-17. By extension, one or more bond scissions, ring expansions and/or ring contractions of the skeleton may have occurred. Natural steroids are derived biogenetically from squalene which is a triterpene." []
+def: "Any of naturally occurring compounds and synthetic analogues, based on the cyclopenta[<em>a</em>]phenanthrene carbon skeleton, partially or completely hydrogenated; there are usually methyl groups at C-10 and C-13, and often an alkyl group at C-17. By extension, one or more bond scissions, ring expansions and/or ring contractions of the skeleton may have occurred. Natural steroids are derived biogenetically from squalene which is a triterpene." []
 is_a: CHEBI:18059 ! lipid
 is_a: CHEBI:51958 ! organic polycyclic compound
 
@@ -1882,12 +1955,12 @@ name: fatty acid
 def: "Any aliphatic monocarboxylic acid derived from or contained in esterified form in an animal or vegetable fat, oil or wax. Natural fatty acids commonly have a chain of 4 to 28 carbons (usually unbranched and even-numbered), which may be saturated or unsaturated. By extension, the term is sometimes used to embrace all acyclic aliphatic carboxylic acids." []
 is_a: CHEBI:18059 ! lipid
 is_a: CHEBI:25384 ! monocarboxylic acid
-relationship: is_conjugate_acid_of CHEBI:28868 ! fatty acid anion
+relationship: RO:0018034 CHEBI:28868 ! is protonated form of fatty acid anion
 
 [Term]
 id: CHEBI:35381
 name: monosaccharide
-def: "Parent monosaccharides are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H-[CHOH]n-C(=O)[CHOH]m-H with three or more carbon atoms. The generic term 'monosaccharide' (as opposed to oligosaccharide or polysaccharide) denotes a single unit, without glycosidic connection to other such units. It includes aldoses, dialdoses, aldoketoses, ketoses and diketoses, as well as deoxy sugars, provided that the parent compound has a (potential) carbonyl group." []
+def: "Parent monosaccharides are polyhydroxy aldehydes H[CH(OH)]<small><sub><em>n</em></sub></small>C(=O)H or polyhydroxy ketones H‒[CHOH]<small><sub><em>n</em></sub></small>‒C(=O)[CHOH]<small><sub><em>m</em></sub></small>‒H with three or more carbon atoms. The generic term 'monosaccharide' (as opposed to oligosaccharide or polysaccharide) denotes a single unit, without glycosidic connection to other such units. It includes aldoses, dialdoses, aldoketoses, ketoses and diketoses, as well as deoxy sugars, provided that the parent compound has a (potential) carbonyl group." []
 is_a: CHEBI:16646 ! carbohydrate
 
 [Term]
@@ -1941,14 +2014,14 @@ is_a: CHEBI:23888 ! drug
 [Term]
 id: CHEBI:35569
 name: alpha-adrenergic agonist
-def: "An agent that selectively binds to and activates alpha-adrenergic receptors." []
+def: "An agent that selectively binds to and activates α-adrenergic receptors." []
 is_a: CHEBI:37886 ! adrenergic agonist
 is_a: CHEBI:48539 ! alpha-adrenergic drug
 
 [Term]
 id: CHEBI:35604
 name: carbon oxoanion
-def: "A negative ion consisting solely of carbon and oxygen  atoms, and therefore having the general formula CxOy(n-) for some integers x, y and n." []
+def: "A negative ion consisting solely of carbon and oxygen  atoms, and therefore having the general formula C<small><sub><em>x</em></sub></small>O<small><sub><em>y</em></sub></small><small><sup><em>n</em>−</small></sup> for some integers <em>x</em>, <em>y</em> and <em>n</em>." []
 is_a: CHEBI:25696 ! organic anion
 is_a: CHEBI:35406 ! oxoanion
 is_a: CHEBI:36963 ! organooxygen compound
@@ -1971,18 +2044,18 @@ name: dicarboxylic acid
 def: "Any carboxylic acid containing two carboxy groups." []
 is_a: CHEBI:131927 ! dicarboxylic acids and O-substituted derivatives
 is_a: CHEBI:33575 ! carboxylic acid
-relationship: is_conjugate_acid_of CHEBI:35693 ! dicarboxylic acid anion
+relationship: RO:0018034 CHEBI:35693 ! is protonated form of dicarboxylic acid anion
 
 [Term]
 id: CHEBI:35693
 name: dicarboxylic acid anion
 is_a: CHEBI:29067 ! carboxylic acid anion
-relationship: is_conjugate_base_of CHEBI:35692 ! dicarboxylic acid
+relationship: RO:0018033 CHEBI:35692 ! is deprotonated form of dicarboxylic acid
 
 [Term]
 id: CHEBI:35701
 name: ester
-def: "A compound formally derived from an oxoacid RkE(=O)l(OH)m (l > 0) and an alcohol, phenol, heteroarenol, or enol by linking with formal loss of water from an acidic hydroxy group of the former and a hydroxy group of the latter." []
+def: "A compound formally derived from an oxoacid R<small><sub><em>k</em></sub></small>E(=O)<small><sub><em>l</em></sub></small>(OH)<small><sub><em>m</em></sub></small> (<em>l</em> > 0) and an alcohol, phenol, heteroarenol, or enol by linking with formal loss of water from an acidic hydroxy group of the former and a hydroxy group of the latter." []
 is_a: CHEBI:36963 ! organooxygen compound
 
 [Term]
@@ -2004,6 +2077,7 @@ name: monocarboxylic acid anion
 def: "A carboxylic acid anion formed when the carboxy group of a monocarboxylic acid is deprotonated." []
 is_a: CHEBI:29067 ! carboxylic acid anion
 relationship: is_conjugate_base_of CHEBI:25384 ! monocarboxylic acid
+relationship: RO:0018033 CHEBI:25384 ! is deprotonated form of monocarboxylic acid
 
 [Term]
 id: CHEBI:35881
@@ -2022,7 +2096,7 @@ is_a: CHEBI:52210 ! pharmacological role
 id: CHEBI:36078
 name: cholanoid
 is_a: CHEBI:35341 ! steroid
-relationship: has_parent_hydride CHEBI:35519 ! cholane
+relationship: RO:0018040 CHEBI:35519 ! has parent hydride cholane
 
 [Term]
 id: CHEBI:36080
@@ -2056,10 +2130,10 @@ is_a: CHEBI:36248 ! 5beta-cholanic acids
 [Term]
 id: CHEBI:36248
 name: 5beta-cholanic acids
-def: "Members of the class of cholanic acids based on a 5beta-cholane skeleton." []
+def: "Members of the class of cholanic acids based on a 5β-cholane skeleton." []
 is_a: CHEBI:136889 ! 5beta steroid
 is_a: CHEBI:36278 ! cholanic acids
-relationship: has_parent_hydride CHEBI:20664 ! 5beta-cholane
+relationship: RO:0018040 CHEBI:20664 ! has parent hydride 5beta-cholane
 
 [Term]
 id: CHEBI:36277
@@ -2209,6 +2283,7 @@ name: amino-acid anion
 is_a: CHEBI:29067 ! carboxylic acid anion
 is_a: CHEBI:35352 ! organonitrogen compound
 relationship: is_conjugate_base_of CHEBI:33709 ! amino acid
+relationship: RO:0018033 CHEBI:33709 ! is deprotonated form of amino acid
 
 [Term]
 id: CHEBI:37163
@@ -2274,6 +2349,7 @@ id: CHEBI:37826
 name: sulfuric acid derivative
 is_a: CHEBI:33424 ! sulfur oxoacid derivative
 relationship: has_functional_parent CHEBI:26836 ! sulfuric acid
+relationship: RO:0018038 CHEBI:26836 ! has functional parent sulfuric acid
 
 [Term]
 id: CHEBI:37838
@@ -2281,6 +2357,7 @@ name: carboacyl group
 def: "A carboacyl group is a group formed by loss of at least one OH from the carboxy group of a carboxylic acid." []
 is_a: CHEBI:22221 ! acyl group
 relationship: is_substituent_group_from CHEBI:33575 ! carboxylic acid
+relationship: RO:0018037 CHEBI:33575 ! is substitutent group from carboxylic acid
 
 [Term]
 id: CHEBI:37886
@@ -2387,18 +2464,18 @@ name: straight-chain saturated fatty acid
 def: "Any saturated fatty acid lacking a side-chain." []
 is_a: CHEBI:26607 ! saturated fatty acid
 is_a: CHEBI:59202 ! straight-chain fatty acid
-relationship: is_conjugate_acid_of CHEBI:58954 ! straight-chain saturated fatty acid anion
+relationship: RO:0018034 CHEBI:58954 ! is protonated form of straight-chain saturated fatty acid anion
 
 [Term]
 id: CHEBI:41609
 name: carbonate
 is_a: CHEBI:35604 ! carbon oxoanion
-relationship: is_conjugate_base_of CHEBI:17544 ! hydrogencarbonate
+relationship: RO:0018033 CHEBI:17544 ! is deprotonated form of hydrogencarbonate
 
 [Term]
 id: CHEBI:4167
 name: D-glucopyranose
-def: "A glucopyranose having D-configuration." []
+def: "A glucopyranose having <small>D</small>-configuration." []
 is_a: CHEBI:17634 ! D-glucose
 is_a: CHEBI:37661 ! glucopyranose
 relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
@@ -2409,7 +2486,7 @@ relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
 [Term]
 id: CHEBI:4194
 name: D-hexose
-def: "A hexose that has D-configuration at position 5." []
+def: "A hexose that has <small>D</small>-configuration at position 5." []
 is_a: CHEBI:18133 ! hexose
 
 [Term]
@@ -2423,6 +2500,8 @@ name: hydrogensulfate
 is_a: CHEBI:33482 ! sulfur oxoanion
 relationship: is_conjugate_acid_of CHEBI:16189 ! sulfate
 relationship: is_conjugate_base_of CHEBI:26836 ! sulfuric acid
+relationship: RO:0018033 CHEBI:26836 ! is deprotonated form of sulfuric acid
+relationship: RO:0018034 CHEBI:16189 ! is protonated form of sulfate
 
 [Term]
 id: CHEBI:46629
@@ -2447,6 +2526,7 @@ name: acetate ester
 def: "Any carboxylic ester where the carboxylic acid component is acetic acid." []
 is_a: CHEBI:33308 ! carboxylic ester
 relationship: has_functional_parent CHEBI:15366 ! acetic acid
+relationship: RO:0018038 CHEBI:15366 ! has functional parent acetic acid
 
 [Term]
 id: CHEBI:47891
@@ -2454,7 +2534,7 @@ name: steroid acid
 def: "Any steroid substituted by at least one carboxy group." []
 is_a: CHEBI:35341 ! steroid
 is_a: CHEBI:64709 ! organic acid
-relationship: is_conjugate_acid_of CHEBI:50160 ! steroid acid anion
+relationship: RO:0018034 CHEBI:50160 ! is protonated form of steroid acid anion
 
 [Term]
 id: CHEBI:48154
@@ -2478,7 +2558,7 @@ is_a: CHEBI:48354 ! polar solvent
 [Term]
 id: CHEBI:48539
 name: alpha-adrenergic drug
-def: "Any drug that acts on an alpha-adrenergic receptor." []
+def: "Any drug that acts on an α-adrenergic receptor." []
 is_a: CHEBI:37962 ! adrenergic agent
 
 [Term]
@@ -2502,13 +2582,14 @@ def: "A compound formally derived from ammonia by replacing one, two or three hy
 is_a: CHEBI:35352 ! organonitrogen compound
 relationship: has_parent_hydride CHEBI:16134 ! ammonia
 relationship: RO:0000087 CHEBI:39142 ! has role Bronsted base
+relationship: RO:0018040 CHEBI:16134 ! has parent hydride ammonia
 
 [Term]
 id: CHEBI:50160
 name: steroid acid anion
 def: "Any anion formed by loss of a proton from a steroid acid." []
 is_a: CHEBI:29067 ! carboxylic acid anion
-relationship: is_conjugate_base_of CHEBI:47891 ! steroid acid
+relationship: RO:0018033 CHEBI:47891 ! is deprotonated form of steroid acid
 
 [Term]
 id: CHEBI:50297
@@ -2589,6 +2670,7 @@ name: primary amino compound
 def: "A compound formally derived from ammonia by replacing one hydrogen atom by an organyl group." []
 is_a: CHEBI:50047 ! organic amino compound
 relationship: is_conjugate_base_of CHEBI:65296 ! primary ammonium ion
+relationship: RO:0018033 CHEBI:65296 ! is deprotonated form of primary ammonium ion
 
 [Term]
 id: CHEBI:51086
@@ -2651,6 +2733,7 @@ is_a: CHEBI:24432 ! biological role
 [Term]
 id: CHEBI:52211
 name: physiological role
+def: "A biological role relating to the normal mechanisms and their interactions within a living system." []
 is_a: CHEBI:24432 ! biological role
 
 [Term]
@@ -2704,6 +2787,7 @@ relationship: is_conjugate_acid_of CHEBI:16765 ! tryptamine
 relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
 relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite
 relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
+relationship: RO:0018034 CHEBI:16765 ! is protonated form of tryptamine
 
 [Term]
 id: CHEBI:57977
@@ -2711,8 +2795,8 @@ name: bilirubin(2-)
 def: "A dicarboxylic acid dianion obtained by deprotonation of the two carboxy groups of bilirubin; major species at pH 7.3." []
 is_a: CHEBI:28965 ! dicarboxylic acid dianion
 is_a: CHEBI:59252 ! linear tetrapyrrole anion
-relationship: is_conjugate_base_of CHEBI:16990 ! bilirubin IXalpha
 relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
+relationship: RO:0018033 CHEBI:16990 ! is deprotonated form of bilirubin IXalpha
 
 [Term]
 id: CHEBI:58942
@@ -2720,18 +2804,19 @@ name: cationic amino-acid residue
 def: "An amino-acid residue protonated on nitrogen." []
 is_a: CHEBI:64769 ! organic cationic group
 relationship: is_conjugate_acid_of CHEBI:33708 ! amino-acid residue
+relationship: RO:0018034 CHEBI:33708 ! is protonated form of amino-acid residue
 
 [Term]
 id: CHEBI:58951
 name: short-chain fatty acid anion
-def: "Any fatty acid anion obtained by removal of a proton from the carboxy group of a short-chain fatty acid (chain length of less than C6)." []
+def: "Any fatty acid anion obtained by removal of a proton from the carboxy group of a short-chain fatty acid (chain length of less than C<small><sub>6</sub></small>)." []
 is_a: CHEBI:28868 ! fatty acid anion
-relationship: is_conjugate_base_of CHEBI:26666 ! short-chain fatty acid
+relationship: RO:0018033 CHEBI:26666 ! is deprotonated form of short-chain fatty acid
 
 [Term]
 id: CHEBI:58953
 name: saturated fatty acid anion
-def: "Any fatty acid anion in which there is no C-C unsaturation." []
+def: "Any fatty acid anion in which there is no C‒C unsaturation." []
 is_a: CHEBI:28868 ! fatty acid anion
 
 [Term]
@@ -2739,7 +2824,7 @@ id: CHEBI:58954
 name: straight-chain saturated fatty acid anion
 def: "Any saturated fatty acid anion lacking a carbon side-chain." []
 is_a: CHEBI:58953 ! saturated fatty acid anion
-relationship: is_conjugate_base_of CHEBI:39418 ! straight-chain saturated fatty acid
+relationship: RO:0018033 CHEBI:39418 ! is deprotonated form of straight-chain saturated fatty acid
 
 [Term]
 id: CHEBI:58958
@@ -2749,20 +2834,22 @@ is_a: CHEBI:25696 ! organic anion
 is_a: CHEBI:33482 ! sulfur oxoanion
 relationship: has_functional_parent CHEBI:16189 ! sulfate
 relationship: is_conjugate_base_of CHEBI:25704 ! organic sulfate
+relationship: RO:0018033 CHEBI:25704 ! is deprotonated form of organic sulfate
+relationship: RO:0018038 CHEBI:16189 ! has functional parent sulfate
 
 [Term]
 id: CHEBI:59202
 name: straight-chain fatty acid
 def: "Any fatty acid whose skeletal carbon atoms form an unbranched open chain." []
 is_a: CHEBI:35366 ! fatty acid
-relationship: is_conjugate_acid_of CHEBI:59203 ! straight-chain fatty acid anion
+relationship: RO:0018034 CHEBI:59203 ! is protonated form of straight-chain fatty acid anion
 
 [Term]
 id: CHEBI:59203
 name: straight-chain fatty acid anion
 def: "A fatty acid anion formed by deprotonation of the carboxylic acid functional group of a straight-chain fatty acid." []
 is_a: CHEBI:28868 ! fatty acid anion
-relationship: is_conjugate_base_of CHEBI:59202 ! straight-chain fatty acid
+relationship: RO:0018033 CHEBI:59202 ! is deprotonated form of straight-chain fatty acid
 
 [Term]
 id: CHEBI:59252
@@ -2780,30 +2867,30 @@ is_a: CHEBI:39144 ! Lewis base
 [Term]
 id: CHEBI:59814
 name: L-alpha-amino acid anion
-def: "Conjugate base of an L-alpha-amino acid arising from deprotonation of the C-1 carboxy group." []
+def: "Conjugate base of an <small>L</small>-α-amino acid arising from deprotonation of the C-1 carboxy group." []
 is_a: CHEBI:33558 ! alpha-amino-acid anion
-relationship: is_conjugate_base_of CHEBI:15705 ! L-alpha-amino acid
+relationship: RO:0018033 CHEBI:15705 ! is deprotonated form of L-alpha-amino acid
 
 [Term]
 id: CHEBI:59869
 name: L-alpha-amino acid zwitterion
-def: "Zwitterionic form of an L-alpha-amino acid having an anionic carboxy group and a protonated amino group." []
+def: "Zwitterionic form of an <small>L</small>-α-amino acid having an anionic carboxy group and a protonated amino group." []
 is_a: CHEBI:78608 ! alpha-amino-acid zwitterion
-relationship: is_tautomer_of CHEBI:15705 ! L-alpha-amino acid
+relationship: RO:0018036 CHEBI:15705 ! is tautomer of L-alpha-amino acid
 
 [Term]
 id: CHEBI:59871
 name: D-alpha-amino acid zwitterion
-def: "Zwitterionic form of a D-alpha-amino acid having an anionic carboxy group and a protonated amino group." []
+def: "Zwitterionic form of a <small>D</small>-α-amino acid having an anionic carboxy group and a protonated amino group." []
 is_a: CHEBI:35238 ! amino-acid zwitterion
-relationship: is_tautomer_of CHEBI:16733 ! D-alpha-amino acid
+relationship: RO:0018036 CHEBI:16733 ! is tautomer of D-alpha-amino acid
 
 [Term]
 id: CHEBI:59888
 name: gamma-aminobutyric acid zwitterion
-def: "Zwitterionic form of gamma-aminobutyric acid having an anionic carboxy group and a protonated amino group." []
+def: "Zwitterionic form of γ-aminobutyric acid having an anionic carboxy group and a protonated amino group." []
 is_a: CHEBI:35238 ! amino-acid zwitterion
-relationship: is_tautomer_of CHEBI:16865 ! gamma-aminobutyric acid
+relationship: RO:0018036 CHEBI:16865 ! is tautomer of gamma-aminobutyric acid
 
 [Term]
 id: CHEBI:59999
@@ -2843,13 +2930,14 @@ name: peptide zwitterion
 def: "Zwitterionic form of any peptide where, in general, the amino terminus is positively charged and the carboxy terminus is negatively charged." []
 is_a: CHEBI:27369 ! zwitterion
 relationship: is_tautomer_of CHEBI:16670 ! peptide
+relationship: RO:0018036 CHEBI:16670 ! is tautomer of peptide
 
 [Term]
 id: CHEBI:60895
 name: D-alpha-amino acid anion
-def: "Any alpha-amino acid anion in which the parent amino acid has D-configuration." []
+def: "Any α-amino acid anion in which the parent amino acid has <small>D</small>-configuration." []
 is_a: CHEBI:33558 ! alpha-amino-acid anion
-relationship: is_conjugate_base_of CHEBI:16733 ! D-alpha-amino acid
+relationship: RO:0018033 CHEBI:16733 ! is deprotonated form of D-alpha-amino acid
 
 [Term]
 id: CHEBI:61115
@@ -2864,6 +2952,7 @@ def: "Any compound that has a nucleobase as a part." []
 is_a: CHEBI:33833 ! heteroarene
 is_a: CHEBI:51143 ! nitrogen molecular entity
 relationship: has_functional_parent CHEBI:18282 ! nucleobase
+relationship: RO:0018038 CHEBI:18282 ! has functional parent nucleobase
 
 [Term]
 id: CHEBI:61469
@@ -2877,7 +2966,7 @@ id: CHEBI:62031
 name: polar amino acid zwitterion
 def: "Zwitterionic form of a polar amino acid having an anionic carboxy group and a protonated amino group." []
 is_a: CHEBI:35238 ! amino-acid zwitterion
-relationship: is_tautomer_of CHEBI:26167 ! polar amino acid
+relationship: RO:0018036 CHEBI:26167 ! is tautomer of polar amino acid
 
 [Term]
 id: CHEBI:62488
@@ -2897,6 +2986,7 @@ name: carbohydrate derivative
 def: "Any organooxygen compound derived from a carbohydrate by replacement of one or more hydroxy group(s) by an amino group, a thiol group or similar heteroatomic groups. The term also includes derivatives of these compounds." []
 is_a: CHEBI:78616 ! carbohydrates and carbohydrate derivatives
 relationship: has_functional_parent CHEBI:16646 ! carbohydrate
+relationship: RO:0018038 CHEBI:16646 ! has functional parent carbohydrate
 
 [Term]
 id: CHEBI:63436
@@ -2905,6 +2995,8 @@ def: "A carbohydrate derivative that is formally obtained from a carbohydrate ac
 is_a: CHEBI:63299 ! carbohydrate derivative
 relationship: has_functional_parent CHEBI:33720 ! carbohydrate acid
 relationship: is_conjugate_acid_of CHEBI:63551 ! carbohydrate acid derivative anion
+relationship: RO:0018034 CHEBI:63551 ! is protonated form of carbohydrate acid derivative anion
+relationship: RO:0018038 CHEBI:33720 ! has functional parent carbohydrate acid
 
 [Term]
 id: CHEBI:63534
@@ -2919,6 +3011,8 @@ def: "A carboxylic acid anion resulting from the deprotonation of the carboxy gr
 is_a: CHEBI:29067 ! carboxylic acid anion
 relationship: has_functional_parent CHEBI:33721 ! carbohydrate acid anion
 relationship: is_conjugate_base_of CHEBI:63436 ! carbohydrate acid derivative
+relationship: RO:0018033 CHEBI:63436 ! is deprotonated form of carbohydrate acid derivative
+relationship: RO:0018038 CHEBI:33721 ! has functional parent carbohydrate acid anion
 
 [Term]
 id: CHEBI:64047
@@ -2976,6 +3070,7 @@ name: organic cationic group
 def: "A cationic group that contains carbon." []
 is_a: CHEBI:64766 ! cationic group
 relationship: is_conjugate_acid_of CHEBI:33247 ! organic group
+relationship: RO:0018034 CHEBI:33247 ! is protonated form of organic group
 
 [Term]
 id: CHEBI:64775
@@ -2983,6 +3078,7 @@ name: organic anionic group
 def: "An anionic group that contains carbon." []
 is_a: CHEBI:64767 ! anionic group
 relationship: is_conjugate_base_of CHEBI:33247 ! organic group
+relationship: RO:0018033 CHEBI:33247 ! is deprotonated form of organic group
 
 [Term]
 id: CHEBI:64898
@@ -2990,6 +3086,7 @@ name: anionic amino-acid residue
 def: "An amino-acid residue carrying an overall negative charge." []
 is_a: CHEBI:64775 ! organic anionic group
 relationship: is_conjugate_base_of CHEBI:33708 ! amino-acid residue
+relationship: RO:0018033 CHEBI:33708 ! is deprotonated form of amino-acid residue
 
 [Term]
 id: CHEBI:64909
@@ -3005,6 +3102,7 @@ is_a: CHEBI:167559 ! glycan
 is_a: CHEBI:33694 ! biomacromolecule
 is_a: CHEBI:63299 ! carbohydrate derivative
 relationship: has_functional_parent CHEBI:18154 ! polysaccharide
+relationship: RO:0018038 CHEBI:18154 ! has functional parent polysaccharide
 
 [Term]
 id: CHEBI:65255
@@ -3026,6 +3124,7 @@ def: "An ammonium ion derivative resulting from the protonation of the nitrogen
 is_a: CHEBI:25697 ! organic cation
 is_a: CHEBI:35274 ! ammonium ion derivative
 relationship: is_conjugate_acid_of CHEBI:50994 ! primary amino compound
+relationship: RO:0018034 CHEBI:50994 ! is protonated form of primary amino compound
 
 [Term]
 id: CHEBI:67079
@@ -3036,17 +3135,18 @@ is_a: CHEBI:33232 ! application
 [Term]
 id: CHEBI:71666
 name: gamma-amino acid anion
-def: "An amino-acid anion in which the amino group is situated gamma- to the carboxylate group." []
+def: "An amino-acid anion in which the amino group is situated γ- to the carboxylate group." []
 is_a: CHEBI:37022 ! amino-acid anion
-relationship: is_conjugate_base_of CHEBI:33707 ! gamma-amino acid
+relationship: RO:0018033 CHEBI:33707 ! is deprotonated form of gamma-amino acid
 
 [Term]
 id: CHEBI:72587
 name: (R)-noradrenaline(1+)
-def: "An organic cation that is the conjugate acid of (R)-noradrenaline, obtained by protonation of the priamry amino group; major species at pH 7.3." []
+def: "An organic cation that is the conjugate acid of (<i>R</i>)-noradrenaline, obtained by protonation of the primary amino group; major species at pH 7.3." []
 is_a: CHEBI:166902 ! noradrenaline(1+)
-relationship: is_conjugate_acid_of CHEBI:18357 ! (R)-noradrenaline
 relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
+relationship: RO:0018034 CHEBI:18357 ! is protonated form of (R)-noradrenaline
+relationship: RO:0018039 CHEBI:234420 ! is enantiomer of (S)-noradrenaline(1+)
 
 [Term]
 id: CHEBI:72695
@@ -3076,7 +3176,7 @@ is_a: CHEBI:52845 ! cyclic organic group
 [Term]
 id: CHEBI:75600
 name: EC 6.3.* (C-N bond-forming ligase) inhibitor
-def: "A ligase inhibitor that interferes with the action of a C-N bond-forming ligase (EC 6.3.*.*)." []
+def: "A ligase inhibitor that interferes with the action of a <em>C</em>‒<em>N</em> bond-forming ligase (EC 6.3.*.*)." []
 is_a: CHEBI:75603 ! EC 6.* (ligase) inhibitor
 
 [Term]
@@ -3106,13 +3206,13 @@ is_a: CHEBI:75767 ! animal metabolite
 [Term]
 id: CHEBI:75771
 name: mouse metabolite
-def: "Any mammalian metabolite produced during a metabolic reaction in a mouse (Mus musculus)." []
+def: "Any mammalian metabolite produced during a metabolic reaction in a mouse (<em>Mus musculus</em>)." []
 is_a: CHEBI:75768 ! mammalian metabolite
 
 [Term]
 id: CHEBI:75772
 name: Saccharomyces cerevisiae metabolite
-def: "Any  fungal metabolite produced during a metabolic reaction in Baker's yeast (Saccharomyces cerevisiae)." []
+def: "Any  fungal metabolite produced during a metabolic reaction in Baker's yeast (<em>Saccharomyces cerevisiae </em>)." []
 is_a: CHEBI:76946 ! fungal metabolite
 
 [Term]
@@ -3148,7 +3248,7 @@ is_a: CHEBI:76764 ! EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibi
 [Term]
 id: CHEBI:76823
 name: EC 6.3.1.* (acid-ammonia/amine ligase) inhibitor
-def: "An EC 6.3.* (C-N bond-forming ligase) inhibitor that interferes with the action of any acid-ammonia (or amine) ligase (EC 6.3.1.*)." []
+def: "An EC 6.3.* (<em>C</em>‒<em>N</em> bond-forming ligase) inhibitor that interferes with the action of any acid-ammonia (or amine) ligase (EC 6.3.1.*)." []
 is_a: CHEBI:75600 ! EC 6.3.* (C-N bond-forming ligase) inhibitor
 
 [Term]
@@ -3179,13 +3279,13 @@ is_a: CHEBI:75787 ! prokaryotic metabolite
 [Term]
 id: CHEBI:76971
 name: Escherichia coli metabolite
-def: "Any bacterial metabolite produced during a metabolic reaction in Escherichia coli." []
+def: "Any bacterial metabolite produced during a metabolic reaction in <em>Escherichia coli</em>." []
 is_a: CHEBI:76969 ! bacterial metabolite
 
 [Term]
 id: CHEBI:77746
 name: human metabolite
-def: "Any mammalian metabolite  produced during a metabolic reaction in humans (Homo sapiens)." []
+def: "Any mammalian metabolite  produced during a metabolic reaction in humans (<em>Homo sapiens</em>)." []
 is_a: CHEBI:75768 ! mammalian metabolite
 
 [Term]
@@ -3206,7 +3306,7 @@ name: fatty acid anion 4:0
 def: "Any saturated fatty acid anion containing 4 carbons. Formed by deprotonation of the carboxylic acid moiety. Major species at pH 7.3." []
 is_a: CHEBI:58951 ! short-chain fatty acid anion
 is_a: CHEBI:58953 ! saturated fatty acid anion
-relationship: is_conjugate_base_of CHEBI:140601 ! fatty acid 4:0
+relationship: RO:0018033 CHEBI:140601 ! is deprotonated form of fatty acid 4:0
 
 [Term]
 id: CHEBI:78295
@@ -3226,11 +3326,12 @@ name: alpha-amino-acid zwitterion
 def: "An amino acid-zwitterion obtained by transfer of a proton from the carboxy to the amino group of any alpha-amino acid; major species at pH 7.3." []
 is_a: CHEBI:35238 ! amino-acid zwitterion
 relationship: is_tautomer_of CHEBI:33704 ! alpha-amino acid
+relationship: RO:0018036 CHEBI:33704 ! is tautomer of alpha-amino acid
 
 [Term]
 id: CHEBI:78616
 name: carbohydrates and carbohydrate derivatives
-def: "Any organooxygen compound that is a polyhydroxy-aldehyde or -ketone, or a compound derived from one. Carbohydrates contain only carbon, hydrogen and oxygen and usually have an empirical formula Cm(H2O)n; carbohydrate derivatives may contain other elements by substitution or condensation." []
+def: "Any organooxygen compound that is a polyhydroxy-aldehyde or -ketone, or a compound derived from one. Carbohydrates contain only carbon, hydrogen and oxygen and usually have an empirical formula C<small><sub><em>m</em></sub></small>(H<small><sub>2</sub></small>O)<small><sub><em>n</em></sub></small>; carbohydrate derivatives may contain other elements by substitution or condensation." []
 is_a: CHEBI:36963 ! organooxygen compound
 
 [Term]
@@ -3260,19 +3361,19 @@ is_a: CHEBI:75767 ! animal metabolite
 [Term]
 id: CHEBI:83056
 name: Daphnia magna metabolite
-def: "A Daphnia metabolite produced by the species Daphnia magna." []
+def: "A <em>Daphnia</em> metabolite produced by the species <em>Daphnia magna</em>." []
 is_a: CHEBI:83057 ! Daphnia metabolite
 
 [Term]
 id: CHEBI:83057
 name: Daphnia metabolite
-def: "A crustacean metabolite produced by the genus of small planktonic arthropods, Daphnia" []
+def: "A crustacean metabolite produced by the genus of small planktonic arthropods, <em>Daphnia</em>" []
 is_a: CHEBI:83039 ! crustacean metabolite
 
 [Term]
 id: CHEBI:83813
 name: proteinogenic amino acid
-def: "Any of the 23 alpha-amino acids that are precursors to proteins, and are incorporated into proteins during translation. The group includes the 20 amino acids encoded by the nuclear genes of eukaryotes together with selenocysteine, pyrrolysine, and N-formylmethionine. Apart from glycine, which is non-chiral, all have L configuration." []
+def: "Any of the 23 α-amino acids that are precursors to proteins, and are incorporated into proteins during translation. The group includes the 20 amino acids encoded by the nuclear genes of eukaryotes together with selenocysteine, pyrrolysine, and <em>N</em>-formylmethionine. Apart from glycine, which is non-chiral, all have <small>L</small> configuration." []
 is_a: CHEBI:33709 ! amino acid
 
 [Term]
@@ -3284,7 +3385,7 @@ is_a: CHEBI:33709 ! amino acid
 [Term]
 id: CHEBI:83925
 name: non-proteinogenic alpha-amino acid
-def: "Any  alpha-amino acid which is not a member of the group of 23 proteinogenic amino acids." []
+def: "Any  α-amino acid which is not a member of the group of 23 proteinogenic amino acids." []
 is_a: CHEBI:33704 ! alpha-amino acid
 is_a: CHEBI:83820 ! non-proteinogenic amino acid
 
@@ -3309,9 +3410,10 @@ is_a: UBERON:0000061 ! anatomical structure
 disjoint_from: GO:0031012 ! extracellular matrix
 disjoint_from: GO:0032991 ! protein-containing complex
 disjoint_from: GO:0043226 ! organelle
+disjoint_from: GO:0044423 ! virion component
 relationship: BFO:0000051 GO:0005634 {gci_filler="PATO:0001407", gci_relation="RO:0000053"} ! has part nucleus
 relationship: BFO:0000051 GO:0005634 {gci_filler="PATO:0001908", gci_relation="RO:0000053"} ! has part nucleus
-relationship: RO:0002162 NCBITaxon:131567 ! in taxon cellular organisms
+relationship: RO:0002162 NCBITaxon:131567 ! in taxon cellular organism
 
 [Term]
 id: CL:0000005
@@ -3973,6 +4075,7 @@ name: chondrocyte
 synonym: "cartilage cell" EXACT []
 is_a: CL:0000153 ! glycosaminoglycan secreting cell
 is_a: CL:0000667 ! collagen secreting cell
+is_a: CL:0007001 ! skeletogenic cell
 relationship: RO:0001025 UBERON:0002418 ! located in cartilage tissue
 relationship: RO:0002202 CL:0000058 ! develops from chondroblast
 
@@ -8864,298 +8967,298 @@ is_a: EMPTY:0000002 ! behavioral measurement
 [Term]
 id: EMPTY:0000006
 name: elevated plus maze: open arm (north) - entries
-def: "In the Elevated Plus Maze task, this counts the number of times the animal's body (typically defined by its center point or a significant portion) fully enters the user-defined zone designated as 'Open Arm (North)'. The 'Open Arm (North)' is one of the two open arms, distinguished by its assigned 'north' orientation or designation in the experimental setup. Unit of measure: count" []
+def: "In the Elevated Plus Maze task, this counts the number of times the animal's body (typically defined by its center point or a significant portion) fully enters the user-defined zone designated as 'Open Arm (North)'. The 'Open Arm (North)' is one of the two open arms, distinguished by its assigned 'north' orientation or designation in the experimental setup. Unit: count" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 
 [Term]
 id: EMPTY:0000007
 name: elevated plus maze: open arm (south) - entries
-def: "In the Elevated Plus Maze task, this counts the number of times the animal's body (typically defined by its center point or a significant portion) fully enters the user-defined zone designated as 'Open Arm (South)'. The 'Open Arm (South)' is one of the two open arms, distinguished by its assigned 'south' orientation or designation in the experimental setup. Unit of measure: count" []
+def: "In the Elevated Plus Maze task, this counts the number of times the animal's body (typically defined by its center point or a significant portion) fully enters the user-defined zone designated as 'Open Arm (South)'. The 'Open Arm (South)' is one of the two open arms, distinguished by its assigned 'south' orientation or designation in the experimental setup. Unit: count" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 
 [Term]
 id: EMPTY:0000008
 name: elevated plus maze: open arm total entries
-def: "In the Elevated Plus Maze task, this represents the total number of times the animal's body (typically defined by its center point or a significant portion) fully enters the designated open arm zones (e.g., 'Open Arm (North)' and 'Open Arm (South)'). It is a common measure of exploration and anxiety. Unit of measure: count" []
+def: "In the Elevated Plus Maze task, this represents the total number of times the animal's body (typically defined by its center point or a significant portion) fully enters the designated open arm zones (e.g., 'Open Arm (North)' and 'Open Arm (South)'). It is a common measure of exploration and anxiety. Unit: count" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 
 [Term]
 id: EMPTY:0000009
 name: elevated plus maze: open arm (north) - head entries
-def: "In the Elevated Plus Maze task, this counts the number of times the animal's head (specifically tracked by the software) enters the user-defined 'Open Arm (North)' zone, irrespective of full body entry. This can indicate risk assessment or tentative exploration of the arm designated as 'north'. Unit of measure: count" []
+def: "In the Elevated Plus Maze task, this counts the number of times the animal's head (specifically tracked by the software) enters the user-defined 'Open Arm (North)' zone, irrespective of full body entry. This can indicate risk assessment or tentative exploration of the arm designated as 'north'. Unit: count" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 
 [Term]
 id: EMPTY:0000010
 name: elevated plus maze: open arm (south) - head entries
-def: "In the Elevated Plus Maze task, this counts the number of times the animal's head (specifically tracked by the software) enters the user-defined 'Open Arm (South)' zone, irrespective of full body entry, often reflecting cautious exploration of the open arm designated as 'south'. Unit of measure: count" []
+def: "In the Elevated Plus Maze task, this counts the number of times the animal's head (specifically tracked by the software) enters the user-defined 'Open Arm (South)' zone, irrespective of full body entry, often reflecting cautious exploration of the open arm designated as 'south'. Unit: count" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 
 [Term]
 id: EMPTY:0000011
 name: elevated plus maze: open arm total head entries
-def: "In the Elevated Plus Maze task, this is the total number of times the animal's head (specifically tracked by the software) enters any of the designated open arm zones (e.g., 'Open Arm (North)' and 'Open Arm (South)'), considered an indicator of risk-assessment behavior. Unit of measure: count" []
+def: "In the Elevated Plus Maze task, this is the total number of times the animal's head (specifically tracked by the software) enters any of the designated open arm zones (e.g., 'Open Arm (North)' and 'Open Arm (South)'), considered an indicator of risk-assessment behavior. Unit: count" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 
 [Term]
 id: EMPTY:0000012
 name: elevated plus maze: open arm (north) - time
-def: "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Open Arm (North)' zone. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Open Arm (North)' zone. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000013
 name: elevated plus maze: open arm (south) - time
-def: "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Open Arm (South)' zone. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Open Arm (South)' zone. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000014
 name: elevated plus maze: open arm total time
-def: "In the Elevated Plus Maze task, this is the cumulative total duration the animal's body spends within any of the designated open arm zones (e.g., 'Open Arm (North)' and 'Open Arm (South)'). Less time is generally indicative of higher anxiety. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this is the cumulative total duration the animal's body spends within any of the designated open arm zones (e.g., 'Open Arm (North)' and 'Open Arm (South)'). Less time is generally indicative of higher anxiety. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000015
 name: elevated plus maze: open arm total - percent time during test duration
-def: "In the Elevated Plus Maze task, this represents the percentage of the total test duration that the animal spends in any of the designated open arm zones (e.g., 'Open Arm (North)' and 'Open Arm (South)'). Unit of measure: %" []
+def: "In the Elevated Plus Maze task, this represents the percentage of the total test duration that the animal spends in any of the designated open arm zones (e.g., 'Open Arm (North)' and 'Open Arm (South)'). Unit: %" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 
 [Term]
 id: EMPTY:0000016
 name: elevated plus maze: open arm (north) - latency to first entry
-def: "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Open Arm (North)' zone. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Open Arm (North)' zone. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000091 ! timepoint
 
 [Term]
 id: EMPTY:0000017
 name: elevated plus maze: open arm (south) - latency to first entry
-def: "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Open Arm (South)' zone. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Open Arm (South)' zone. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000091 ! timepoint
 
 [Term]
 id: EMPTY:0000018
 name: elevated plus maze: open arm total latency to first entry
-def: "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into any of the designated open arm zones (e.g., 'Open Arm (North)' or 'Open Arm (South)'). Longer latencies often suggest higher anxiety. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into any of the designated open arm zones (e.g., 'Open Arm (North)' or 'Open Arm (South)'). Longer latencies often suggest higher anxiety. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000091 ! timepoint
 
 [Term]
 id: EMPTY:0000019
 name: elevated plus maze: open arm (north) - time moving towards
-def: "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Open Arm (North)' zone, as detected by the tracking software. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Open Arm (North)' zone, as detected by the tracking software. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000020
 name: elevated plus maze: open arm (south) - time moving towards
-def: "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Open Arm (South)' zone, as detected by the tracking software. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Open Arm (South)' zone, as detected by the tracking software. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000021
 name: elevated plus maze: open arm total time moving towards
-def: "In the Elevated Plus Maze task, this is the cumulative duration the animal spends actively moving towards any of the designated open arm zones (e.g., 'Open Arm (North)' or 'Open Arm (South)'), reflecting approach motivation. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this is the cumulative duration the animal spends actively moving towards any of the designated open arm zones (e.g., 'Open Arm (North)' or 'Open Arm (South)'), reflecting approach motivation. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000022
 name: elevated plus maze: open arm (north) - time freezing
-def: "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior (a state of immobility except for respiratory movements) while within the user-defined 'Open Arm (North)' zone. Freezing is a common fear response. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior (a state of immobility except for respiratory movements) while within the user-defined 'Open Arm (North)' zone. Freezing is a common fear response. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000023
 name: elevated plus maze: open arm (south) - time freezing
-def: "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined 'Open Arm (South)' zone. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined 'Open Arm (South)' zone. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000024
 name: elevated plus maze: open arm total time freezing
-def: "In the Elevated Plus Maze task, this is the cumulative duration the animal exhibits freezing behavior while within any of the designated open arm zones (e.g., 'Open Arm (North)' or 'Open Arm (South)'), indicating fear or anxiety. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this is the cumulative duration the animal exhibits freezing behavior while within any of the designated open arm zones (e.g., 'Open Arm (North)' or 'Open Arm (South)'), indicating fear or anxiety. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000025
 name: elevated plus maze: closed arm (west) - entries
-def: "In the Elevated Plus Maze task, this counts the number of times the animal's body fully enters the user-defined 'Closed Arm (West)' zone, representing the enclosed arm designated as 'west'. Unit of measure: count" []
+def: "In the Elevated Plus Maze task, this counts the number of times the animal's body fully enters the user-defined 'Closed Arm (West)' zone, representing the enclosed arm designated as 'west'. Unit: count" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 
 [Term]
 id: EMPTY:0000026
 name: elevated plus maze: closed arm (east) - entries
-def: "In the Elevated Plus Maze task, this counts the number of times the animal's body fully enters the user-defined 'Closed Arm (East)' zone, representing the enclosed arm designated as 'east'. Unit of measure: count" []
+def: "In the Elevated Plus Maze task, this counts the number of times the animal's body fully enters the user-defined 'Closed Arm (East)' zone, representing the enclosed arm designated as 'east'. Unit: count" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 
 [Term]
 id: EMPTY:0000027
 name: elevated plus maze: closed arm total entries
-def: "In the Elevated Plus Maze task, this is the total number of times the animal's body fully enters any of the designated closed arm zones (e.g., 'Closed Arm (West)' and 'Closed Arm (East)'). It is often used as an indicator of general locomotor activity. Unit of measure: count" []
+def: "In the Elevated Plus Maze task, this is the total number of times the animal's body fully enters any of the designated closed arm zones (e.g., 'Closed Arm (West)' and 'Closed Arm (East)'). It is often used as an indicator of general locomotor activity. Unit: count" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 
 [Term]
 id: EMPTY:0000028
 name: elevated plus maze: closed arm (west) - head entries
-def: "In the Elevated Plus Maze task, this counts the number of times the animal's head enters the user-defined 'Closed Arm (West)' zone. Unit of measure: count" []
+def: "In the Elevated Plus Maze task, this counts the number of times the animal's head enters the user-defined 'Closed Arm (West)' zone. Unit: count" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 
 [Term]
 id: EMPTY:0000029
 name: elevated plus maze: closed arm (east) - head entries
-def: "In the Elevated Plus Maze task, this counts the number of times the animal's head enters the user-defined 'Closed Arm (East)' zone. Unit of measure: count" []
+def: "In the Elevated Plus Maze task, this counts the number of times the animal's head enters the user-defined 'Closed Arm (East)' zone. Unit: count" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 
 [Term]
 id: EMPTY:0000030
 name: elevated plus maze: closed arm total head entries
-def: "In the Elevated Plus Maze task, this is the total number of times the animal's head enters any of the designated closed arm zones (e.g., 'Closed Arm (West)' and 'Closed Arm (East)'). Unit of measure: count" []
+def: "In the Elevated Plus Maze task, this is the total number of times the animal's head enters any of the designated closed arm zones (e.g., 'Closed Arm (West)' and 'Closed Arm (East)'). Unit: count" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 
 [Term]
 id: EMPTY:0000031
 name: elevated plus maze: closed arm (west) - time
-def: "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Closed Arm (West)' zone. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Closed Arm (West)' zone. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000032
 name: elevated plus maze: closed arm (east) - time
-def: "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Closed Arm (East)' zone. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Closed Arm (East)' zone. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000033
 name: elevated plus maze: closed arm total time
-def: "In the Elevated Plus Maze task, this is the cumulative total duration the animal's body spends within any of the designated closed arm zones (e.g., 'Closed Arm (West)' and 'Closed Arm (East)'). Animals typically spend more time in these 'safer' areas. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this is the cumulative total duration the animal's body spends within any of the designated closed arm zones (e.g., 'Closed Arm (West)' and 'Closed Arm (East)'). Animals typically spend more time in these 'safer' areas. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000034
 name: elevated plus maze: closed arm total - percent time during test duration
-def: "In the Elevated Plus Maze task, this represents the percentage of the total test duration that the animal spends in any of the designated closed arm zones (e.g., 'Closed Arm (West)' and 'Closed Arm (East)'). Unit of measure: %" []
+def: "In the Elevated Plus Maze task, this represents the percentage of the total test duration that the animal spends in any of the designated closed arm zones (e.g., 'Closed Arm (West)' and 'Closed Arm (East)'). Unit: %" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 
 [Term]
 id: EMPTY:0000035
 name: elevated plus maze: closed arm (west) - latency to first entry
-def: "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Closed Arm (West)' zone. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Closed Arm (West)' zone. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000091 ! timepoint
 
 [Term]
 id: EMPTY:0000036
 name: elevated plus maze: closed arm (east) - latency to first entry
-def: "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Closed Arm (East)' zone. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Closed Arm (East)' zone. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000091 ! timepoint
 
 [Term]
 id: EMPTY:0000037
 name: elevated plus maze: closed arm total latency to first entry
-def: "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into any of the designated closed arm zones (e.g., 'Closed Arm (West)' or 'Closed Arm (East)'). Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into any of the designated closed arm zones (e.g., 'Closed Arm (West)' or 'Closed Arm (East)'). Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000091 ! timepoint
 
 [Term]
 id: EMPTY:0000038
 name: elevated plus maze: closed arm (west) - time moving towards
-def: "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Closed Arm (West)' zone. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Closed Arm (West)' zone. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000039
 name: elevated plus maze: closed arm (east) - time moving towards
-def: "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Closed Arm (East)' zone. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Closed Arm (East)' zone. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000040
 name: elevated plus maze: closed arm total time moving towards
-def: "In the Elevated Plus Maze task, this is the cumulative duration the animal spends actively moving towards any of the designated closed arm zones (e.g., 'Closed Arm (West)' or 'Closed Arm (East)'). Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this is the cumulative duration the animal spends actively moving towards any of the designated closed arm zones (e.g., 'Closed Arm (West)' or 'Closed Arm (East)'). Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000041
 name: elevated plus maze: closed arm (west) - time freezing
-def: "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined 'Closed Arm (West)' zone. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined 'Closed Arm (West)' zone. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000042
 name: elevated plus maze: closed arm (east) - time freezing
-def: "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined 'Closed Arm (East)' zone. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined 'Closed Arm (East)' zone. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000043
 name: elevated plus maze: closed arm total time freezing
-def: "In the Elevated Plus Maze task, this is the cumulative duration the animal exhibits freezing behavior while within any of the designated closed arm zones (e.g., 'Closed Arm (West)' or 'Closed Arm (East)'). Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this is the cumulative duration the animal exhibits freezing behavior while within any of the designated closed arm zones (e.g., 'Closed Arm (West)' or 'Closed Arm (East)'). Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000044
 name: elevated plus maze: center - entries
-def: "In the Elevated Plus Maze task, this counts the number of times the animal's body fully enters the user-defined 'Center' zone of the maze, typically from one of the arms. The center zone is the area where all four arms meet. Unit of measure: count" []
+def: "In the Elevated Plus Maze task, this counts the number of times the animal's body fully enters the user-defined 'Center' zone of the maze, typically from one of the arms. The center zone is the area where all four arms meet. Unit: count" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 
 [Term]
 id: EMPTY:0000045
 name: elevated plus maze: center - head entries
-def: "In the Elevated Plus Maze task, this counts the number of times the animal's head enters the user-defined 'Center' zone of the maze. Unit of measure: count" []
+def: "In the Elevated Plus Maze task, this counts the number of times the animal's head enters the user-defined 'Center' zone of the maze. Unit: count" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 
 [Term]
 id: EMPTY:0000046
 name: elevated plus maze: center - time
-def: "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Center' zone. Time in the center can indicate decision-making or risk assessment. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Center' zone. Time in the center can indicate decision-making or risk assessment. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000047
 name: elevated plus maze: center - percent time during test duration
-def: "In the Elevated Plus Maze task, this represents the percentage of the total test duration that the animal spends in the user-defined 'Center' zone of the maze. Unit of measure: %" []
+def: "In the Elevated Plus Maze task, this represents the percentage of the total test duration that the animal spends in the user-defined 'Center' zone of the maze. Unit: %" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 
 [Term]
 id: EMPTY:0000048
 name: elevated plus maze: center - latency to first entry
-def: "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Center' zone. If the animal starts in the center, this value may be zero or not applicable. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Center' zone. If the animal starts in the center, this value may be zero or not applicable. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000091 ! timepoint
 
 [Term]
 id: EMPTY:0000049
 name: elevated plus maze: center - time moving towards
-def: "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Center' zone of the maze (e.g., from an arm). Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Center' zone of the maze (e.g., from an arm). Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
 [Term]
 id: EMPTY:0000050
 name: elevated plus maze: center - time freezing
-def: "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined 'Center' zone of the maze. Freezing in this relatively exposed area can indicate high anxiety. Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined 'Center' zone of the maze. Freezing in this relatively exposed area can indicate high anxiety. Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 
@@ -9174,7 +9277,7 @@ is_a: EMPTY:0000084 ! categorical identifier
 [Term]
 id: EMPTY:0000053
 name: fear-potentiated startle: baseline acoustic startle response amplitude
-def: "In the Fear-potentiated startle paradigm, this is the amplitude of the acoustic startle response (ASR) measured in response to a startle-eliciting stimulus (e.g., 95-dB white noise burst) prior to any fear conditioning procedures, typically assessed during habituation or pre-conditioning phase. This measurement serves as a reference point for later comparisons with post-conditioning startle responses. Unit of measure: arbitrary units or standardized score." []
+def: "In the Fear-potentiated startle paradigm, this is the amplitude of the acoustic startle response (ASR) measured in response to a startle-eliciting stimulus (e.g., 95-dB white noise burst) prior to any fear conditioning procedures, typically assessed during habituation or pre-conditioning phase. This measurement serves as a reference point for later comparisons with post-conditioning startle responses. Unit: arbitrary units or standardized score." []
 is_a: EMPTY:0000004 ! acoustic startle response measurement
 is_a: EMPTY:0000162 ! amplitude
 
@@ -9206,7 +9309,7 @@ is_a: EMPTY:0000093 ! fear-potentiated startle parameter
 [Term]
 id: EMPTY:0000058
 name: fear-potentiated startle: apparatus chamber identifier
-def: "Identifier for the specific Plexiglas enclosure or sound-attenuating chamber within the Fear-Potentiated Startle (FPS) apparatus (e.g., San Diego Instruments SR-Lab) in which a subject was tested for a given trial. Unit of measure: count or identifier string" []
+def: "Identifier for the specific Plexiglas enclosure or sound-attenuating chamber within the Fear-Potentiated Startle (FPS) apparatus (e.g., San Diego Instruments SR-Lab) in which a subject was tested for a given trial. Unit: count or identifier string" []
 is_a: EMPTY:0000093 ! fear-potentiated startle parameter
 
 [Term]
@@ -9218,40 +9321,40 @@ is_a: EMPTY:0000084 ! categorical identifier
 [Term]
 id: EMPTY:0000060
 name: acoustic startle response: number of samples
-def: "The total number of data points (samples) recorded and analyzed for a single acoustic startle response, typically within a defined time window following stimulus onset (e.g., a 200-ms window as mentioned in the manuscript). Unit of measure: count" []
+def: "The total number of data points (samples) recorded and analyzed for a single acoustic startle response, typically within a defined time window following stimulus onset (e.g., a 200-ms window as mentioned in the manuscript). Unit: count" []
 is_a: EMPTY:0000093 ! fear-potentiated startle parameter
 
 [Term]
 id: EMPTY:0000061
 name: acoustic startle response: sampling rate
-def: "The rate at which the analog startle response signal was digitized during data acquisition. Unit of measure: Hertz (Hz)" []
+def: "The rate at which the analog startle response signal was digitized during data acquisition. Unit: Hertz (Hz)" []
 is_a: EMPTY:0000093 ! fear-potentiated startle parameter
 
 [Term]
 id: EMPTY:0000062
 name: acoustic startle response: startle window onset amplitude
-def: "The amplitude of the digitized acoustic startle response signal at the very beginning (onset) of the defined analysis window (e.g., a 200-ms window) used to quantify the reflex. Unit of measure: millivolts (mV) or arbitrary units based on transducer calibration." []
+def: "The amplitude of the digitized acoustic startle response signal at the very beginning (onset) of the defined analysis window (e.g., a 200-ms window) used to quantify the reflex. Unit: millivolts (mV) or arbitrary units based on transducer calibration." []
 is_a: EMPTY:0000004 ! acoustic startle response measurement
 is_a: EMPTY:0000162 ! amplitude
 
 [Term]
 id: EMPTY:0000063
 name: acoustic startle response: maximum amplitude
-def: "The peak amplitude of the acoustic startle response (e.g., 'jump amplitude') detected within the defined analysis window (e.g., 200-ms window) for a given trial. Unit of measure: millivolts (mV) or arbitrary units." []
+def: "The peak amplitude of the acoustic startle response (e.g., 'jump amplitude') detected within the defined analysis window (e.g., 200-ms window) for a given trial. Unit: millivolts (mV) or arbitrary units." []
 is_a: EMPTY:0000004 ! acoustic startle response measurement
 is_a: EMPTY:0000162 ! amplitude
 
 [Term]
 id: EMPTY:0000064
 name: acoustic startle response: time to maximum amplitude
-def: "The latency from the onset of the startle-eliciting stimulus (or the beginning of the analysis window) to the occurrence of the maximum (peak) amplitude of the acoustic startle response. Unit of measure: milliseconds (ms)" []
+def: "The latency from the onset of the startle-eliciting stimulus (or the beginning of the analysis window) to the occurrence of the maximum (peak) amplitude of the acoustic startle response. Unit: milliseconds (ms)" []
 is_a: EMPTY:0000004 ! acoustic startle response measurement
 is_a: EMPTY:0000091 ! timepoint
 
 [Term]
 id: EMPTY:0000065
 name: acoustic startle response: average amplitude
-def: "The average amplitude of the digitized acoustic startle response signal calculated across the entire duration of the defined analysis window (e.g., 200-ms window). Unit of measure: millivolts (mV) or arbitrary units." []
+def: "The average amplitude of the digitized acoustic startle response signal calculated across the entire duration of the defined analysis window (e.g., 200-ms window). Unit: millivolts (mV) or arbitrary units." []
 is_a: EMPTY:0000004 ! acoustic startle response measurement
 is_a: EMPTY:0000162 ! amplitude
 
@@ -9271,7 +9374,7 @@ is_a: EMPTY:0000093 ! fear-potentiated startle parameter
 [Term]
 id: EMPTY:0000068
 name: elevated plus maze: test duration
-def: "In the Elevated Plus Maze task, this is the time of the total test duration in seconds'). Unit of measure: seconds" []
+def: "In the Elevated Plus Maze task, this is the time of the total test duration in seconds'). Unit: seconds" []
 is_a: EMPTY:0000003 ! elevated plus maze measurement
 is_a: EMPTY:0000090 ! duration
 is_a: EMPTY:0000092 ! elevated plus maze parameter
@@ -9975,13 +10078,13 @@ is_a: EMPTY:0000164 ! contextual fear conditioning parameter
 [Term]
 id: EMPTY:0000175
 name: contextual fear conditioning: time freezing
-def: "The number of seconds the individual spent freezing during a given period of time. Unit of measure: seconds" []
+def: "The number of seconds the individual spent freezing during a given period of time. Unit: seconds" []
 is_a: EMPTY:0000163 ! contextual fear conditioning measurement
 
 [Term]
 id: EMPTY:0000176
 name: contextual fear conditioning: block duration
-def: "In the contextual fear conditioning paradigm, this is the time of the block duration in seconds. Unit of measure: seconds" []
+def: "In the contextual fear conditioning paradigm, this is the time of the block duration in seconds. Unit: seconds" []
 is_a: EMPTY:0000163 ! contextual fear conditioning measurement
 is_a: EMPTY:0000164 ! contextual fear conditioning parameter
 
@@ -10321,6 +10424,175 @@ name: unknown electronic file type
 def: "A digital file for which the format, encoding, or origin cannot be definitively identified by the system or investigator, necessitating further manual review or specialized software for interpretation." []
 is_a: NCIT:C172272 ! Electronic File Content Type
 
+[Term]
+id: EMPTY:0000231
+name: C. elegans chemotaxis assay parameter
+def: "A parameter that specifies the technical settings, environmental conditions, or experimental design of a chemotaxis assay involving Caenorhabditis elegans." []
+is_a: EMPTY:0000101 ! C. elegans behavioral assay parameter
+
+[Term]
+id: EMPTY:0000232
+name: C. elegans chemotaxis assay parameter: chemoattractant mixture table
+def: "A table containing the quantities and identities of all chemicals used as a chemoattractant (e.g., isoamyl alcohol, diacetyl) to elicit a directed movement response in C. elegans." []
+is_a: EMPTY:0000231 ! C. elegans chemotaxis assay parameter
+
+[Term]
+id: EMPTY:0000233
+name: C. elegans chemotaxis assay parameter: chemoattractant mixture volume
+def: "The volume of the chemoattractant mixture pipetted onto the agar plate in a chemotaxis assay. Unit: microliters (μL)." []
+is_a: EMPTY:0000231 ! C. elegans chemotaxis assay parameter
+
+[Term]
+id: EMPTY:0000234
+name: C. elegans chemotaxis assay parameter: assay duration
+def: "The total time elapsed from the point at which C. elegans are placed on the assay plate until the movement is arrested or the final positions are recorded. Unit: minutes." []
+is_a: EMPTY:0000231 ! C. elegans chemotaxis assay parameter
+
+[Term]
+id: EMPTY:0000235
+name: C. elegans chemotaxis assay measurement
+def: "A quantitative or qualitative value derived from a C. elegans chemotaxis assay, typically describing the efficiency or directionality of the animals' movement toward or away from a chemical source." []
+is_a: EMPTY:0000100 ! C. elegans behavioral assay measurement
+
+[Term]
+id: EMPTY:0000236
+name: C. elegans chemotaxis assay measurement: McCutcheon index
+def: "A behavioral measurement of chemotactic efficiency defined as the ratio of the straight-line displacement toward the attractant to the total path length traveled by the organism. Values range from -1 to 1." []
+synonym: "chemotactic ratio" EXACT []
+is_a: EMPTY:0000235 ! C. elegans chemotaxis assay measurement
+
+[Term]
+id: EMPTY:0000237
+name: C. elegans chemotaxis assay measurement: mean velocity
+def: "The average speed of a C. elegans individual or population during the duration of the chemotaxis assay. Unit: micrometers per second (µm/s)." []
+is_a: EMPTY:0000235 ! C. elegans chemotaxis assay measurement
+
+[Term]
+id: EMPTY:0000238
+name: investigator-defined strain
+def: "A specific genetic variant or line of an organism designated by the investigator, often containing unique mutations, transgenes, or genomic edits not yet categorized in a public repository." []
+is_a: EMPTY:0000076 ! descriptor
+
+[Term]
+id: EMPTY:0000239
+name: C. elegans strain
+def: "A specific strain of Caenorhabditis elegans, identified by its genotype or a standard nomenclature (e.g., N2, CB4856), used in experimental procedures." []
+is_a: EMPTY:0000238 ! investigator-defined strain
+
+[Term]
+id: EMPTY:0000240
+name: BAB9001
+def: "A C. elegans strain with the genotype daf-22 (m130). This strain was originally obtained from the Caenorhabditis Genetics Center (CGC) as strain DR476 and subsequently outcrossed three times. [Source: https://doi.org/TBD]" []
+is_a: EMPTY:0000239 ! C. elegans strain
+
+[Term]
+id: EMPTY:0000241
+name: BAB9002
+def: "A C. elegans klp-6 rescue strain with the genotype klp-6 (my8); Pklp-6::GFP::KLP-6 (array, IndEx 9002). [Source: https://doi.org/TBD]" []
+is_a: EMPTY:0000239 ! C. elegans strain
+
+[Term]
+id: EMPTY:0000242
+name: TM5848
+def: "A C. elegans strain with the genotype cil-7 (tm5848) I, exhibiting a him phenotype. This strain was obtained from the National BioResource Project (NBRP), Japan. [Source: https://doi.org/TBD]" []
+is_a: EMPTY:0000239 ! C. elegans strain
+
+[Term]
+id: EMPTY:0000243
+name: PT3602
+def: "A C. elegans strain with the genotype cil-7 (my61[cil-7::mNG])I; him-5(e1490) V. This strain was provided as a gift from the Maureen Barr lab. [Source: https://doi.org/TBD]" []
+is_a: EMPTY:0000239 ! C. elegans strain
+
+[Term]
+id: EMPTY:0000244
+name: BAB9003
+def: "A C. elegans strain with the genotype PT3602; Pnlp-43_hCaspase nZ (array IndEx 9003). [Source: https://doi.org/TBD]" []
+is_a: EMPTY:0000239 ! C. elegans strain
+
+[Term]
+id: EMPTY:0000245
+name: BAB9004
+def: "A C. elegans strain with the genotype PT3602; Pklp-6_hCaspase Cz (array IndEx 9004). [Source: https://doi.org/TBD]" []
+is_a: EMPTY:0000239 ! C. elegans strain
+
+[Term]
+id: EMPTY:0000246
+name: BAB9005
+def: "A C. elegans strain with the genotype PT3602; Pnlp-43_hCaspase nZ (array IndEx 9003) and Pklp-6_hCaspase Cz (array IndEx 9004). [Source: https://doi.org/TBD]" []
+is_a: EMPTY:0000239 ! C. elegans strain
+
+[Term]
+id: EMPTY:0000247
+name: fluorescence imaging measurement
+def: "fluorescence imaging measurement" []
+is_a: EMPTY:0000001 ! measurement
+
+[Term]
+id: EMPTY:0000248
+name: mean fluorescence intensity
+def: "Mean fluorescence intensity. Unit: arbitrary units (AU)" []
+is_a: EMPTY:0000247 ! fluorescence imaging measurement
+
+[Term]
+id: EMPTY:0000249
+name: fluorescent punctal count
+def: "A quantitative measurement of the number of distinct fluorescent spots or puncta detected within a defined region of interest in a fluorescence image. Unit: count" []
+is_a: EMPTY:0000247 ! fluorescence imaging measurement
+
+[Term]
+id: EMPTY:0000250
+name: fluorescence imaging parameter
+def: "A specific parameter related to fluorescence imaging acquisition or assay." []
+is_a: EMPTY:0000080 ! parameter
+
+[Term]
+id: EMPTY:0000251
+name: fluorescence target ontology identifier
+def: "fluorescence target ontology identifier" []
+is_a: EMPTY:0000250 ! fluorescence imaging parameter
+
+[Term]
+id: EMPTY:0000252
+name: fluorescence target name
+def: "fluorescence target name" []
+is_a: EMPTY:0000250 ! fluorescence imaging parameter
+
+[Term]
+id: EMPTY:0000253
+name: SnapGene file format
+def: "A .dna file format designed for storing annotated DNA sequences, including linear/circular topology, features, primers, and enzyme sites." []
+is_a: format:1929
+
+[Term]
+id: EMPTY:0000254
+name: Escherichia coli OP50: heat-killed
+def: "A preparation of Escherichia coli strain OP50 that has been rendered non-viable through the application of heat, typically used as a non-proliferating food source in C. elegans assays." []
+is_a: NCBITaxon:637912 ! Escherichia coli OP50
+
+[Term]
+id: EMPTY:0000255
+name: C. elegans transfer method: M9 buffer wash
+def: "Method used to transfer C. elegans whereby an M9 buffer is used to wash C. elegans off of an agar plate. Animals can then be transferred using a piper." []
+is_a: EMPTY:0000189 ! treatment
+
+[Term]
+id: EMPTY:0000256
+name: C. elegans transfer method: titanium pick
+def: "Method used to transfer C. elegans whereby a titanium pick is used to scoop animals off of an agar plate." []
+is_a: EMPTY:0000189 ! treatment
+
+[Term]
+id: EMPTY:0000257
+name: C. elegans chemotaxis assay: video recording
+def: "A video recording capturing the behavior of C. elegans during a chemotaxis assay." []
+is_a: EMPTY:0000129 ! C. elegans behavioral assay: video recording
+
+[Term]
+id: EMPTY:0000258
+name: fluorescence imaging data
+def: "An image or video acquired using fluorescence microscopy." []
+is_a: NCIT:C16856 ! Fluorescence Microscopy
+
 [Term]
 id: GO:0000011
 name: vacuole inheritance
@@ -16125,6 +16397,7 @@ name: biological_process
 synonym: "biological process" EXACT []
 synonym: "physiological process" EXACT []
 is_a: BFO:0000015 ! process
+relationship: BFO:0000051 GO:0003674 ! has part molecular_function
 
 [Term]
 id: GO:0008152
@@ -17085,6 +17358,14 @@ intersection_of: GO:0008356 ! asymmetric cell division
 intersection_of: RO:0004009 CL:0000365 ! has primary input animal zygote
 relationship: RO:0004009 CL:0000365 ! has primary input animal zygote
 
+[Term]
+id: GO:0010155
+name: regulation of proton transport
+is_a: GO:1904062 ! regulation of monoatomic cation transmembrane transport
+intersection_of: GO:0065007 ! biological regulation
+intersection_of: RO:0002211 GO:1902600 ! regulates (processual) proton transmembrane transport
+relationship: RO:0002211 GO:1902600 ! regulates (processual) proton transmembrane transport
+
 [Term]
 id: GO:0010160
 name: formation of animal organ boundary
@@ -18776,22 +19057,6 @@ intersection_of: GO:0050896 ! response to stimulus
 intersection_of: BFO:0000050 GO:0043502 ! part of regulation of muscle adaptation
 relationship: BFO:0000050 GO:0043502 ! part of regulation of muscle adaptation
 
-[Term]
-id: GO:0014878
-name: response to electrical stimulus involved in regulation of muscle adaptation
-is_a: GO:0014874 ! response to stimulus involved in regulation of muscle adaptation
-is_a: GO:0051602 ! response to electrical stimulus
-intersection_of: GO:0051602 ! response to electrical stimulus
-intersection_of: BFO:0000050 GO:0043502 ! part of regulation of muscle adaptation
-
-[Term]
-id: GO:0014879
-name: detection of electrical stimulus involved in regulation of muscle adaptation
-is_a: GO:0014878 ! response to electrical stimulus involved in regulation of muscle adaptation
-is_a: GO:0050981 ! detection of electrical stimulus
-intersection_of: GO:0050981 ! detection of electrical stimulus
-intersection_of: BFO:0000050 GO:0043502 ! part of regulation of muscle adaptation
-
 [Term]
 id: GO:0014887
 name: cardiac muscle adaptation
@@ -18899,6 +19164,18 @@ intersection_of: RO:0004009 CHEBI:24867 ! has primary input monoatomic ion
 relationship: BFO:0000050 GO:0034220 ! part of monoatomic ion transmembrane transport
 relationship: RO:0004009 CHEBI:24867 ! has primary input monoatomic ion
 
+[Term]
+id: GO:0015078
+name: proton transmembrane transporter activity
+synonym: "hydrogen ion transmembrane transporter activity" EXACT []
+synonym: "proton transporter activity" EXACT []
+is_a: GO:0008324 ! monoatomic cation transmembrane transporter activity
+intersection_of: GO:0005215 ! transporter activity
+intersection_of: RO:0002342 GO:0016020 ! results in transport across membrane
+intersection_of: RO:0004009 CHEBI:15378 ! has primary input hydron
+relationship: BFO:0000050 GO:1902600 ! part of proton transmembrane transport
+relationship: RO:0004009 CHEBI:15378 ! has primary input hydron
+
 [Term]
 id: GO:0015081
 name: sodium ion transmembrane transporter activity
@@ -19836,7 +20113,7 @@ intersection_of: GO:0042592 ! homeostatic process
 intersection_of: BFO:0000066 CL:0000000 ! occurs in cell
 disjoint_from: GO:0048872 ! homeostasis of number of cells
 relationship: BFO:0000066 CL:0000000 ! occurs in cell
-relationship: RO:0002162 NCBITaxon:131567 ! in taxon cellular organisms
+relationship: RO:0002162 NCBITaxon:131567 ! in taxon cellular organism
 
 [Term]
 id: GO:0019748
@@ -22229,6 +22506,7 @@ synonym: "proteinaceous extracellular matrix" EXACT []
 is_a: GO:0030312 ! external encapsulating structure
 disjoint_from: GO:0032991 ! protein-containing complex
 disjoint_from: GO:0043226 ! organelle
+disjoint_from: GO:0044423 ! virion component
 
 [Term]
 id: GO:0031016
@@ -23425,7 +23703,7 @@ is_a: GO:0045185 ! maintenance of protein location
 is_a: GO:0051651 ! maintenance of location in cell
 intersection_of: GO:0045185 ! maintenance of protein location
 intersection_of: BFO:0000066 CL:0000000 ! occurs in cell
-relationship: RO:0002162 NCBITaxon:131567 ! in taxon cellular organisms
+relationship: RO:0002162 NCBITaxon:131567 ! in taxon cellular organism
 
 [Term]
 id: GO:0032528
@@ -23858,6 +24136,7 @@ synonym: "macromolecule complex" EXACT []
 synonym: "protein containing complex" EXACT []
 is_a: COB:0000080 ! complex of molecules
 is_a: GO:0005575 ! cellular_component
+disjoint_from: GO:0044423 ! virion component
 disjoint_from: GO:0110165 ! cellular anatomical entity
 relationship: BFO:0000051 PR:000000001 ! has part protein
 property_value: IAO:0000118 "protein complex" xsd:string
@@ -25365,7 +25644,7 @@ relationship: RO:0012008 GO:0000139 ! results in fusion of Golgi membrane
 id: GO:0040007
 name: growth
 is_a: GO:0008150 ! biological_process
-relationship: RO:0002162 NCBITaxon:131567 ! in taxon cellular organisms
+relationship: RO:0002162 NCBITaxon:131567 ! in taxon cellular organism
 
 [Term]
 id: GO:0040008
@@ -26540,6 +26819,7 @@ relationship: BFO:0000050 CL:0000125 ! part of glial cell
 id: GO:0043226
 name: organelle
 is_a: GO:0110165 ! cellular anatomical entity
+disjoint_from: GO:0044423 ! virion component
 
 [Term]
 id: GO:0043227
@@ -26814,7 +27094,7 @@ relationship: RO:0002211 GO:0016052 ! regulates (processual) carbohydrate catabo
 id: GO:0043473
 name: pigmentation
 is_a: GO:0008150 ! biological_process
-relationship: RO:0002162 NCBITaxon:131567 ! in taxon cellular organisms
+relationship: RO:0002162 NCBITaxon:131567 ! in taxon cellular organism
 
 [Term]
 id: GO:0043500
@@ -27310,7 +27590,9 @@ is_a: GO:0008150 ! biological_process
 id: GO:0044423
 name: virion component
 def: "Any constituent part of a virion, a complete fully infectious extracellular virus particle." []
+synonym: "virion part" EXACT []
 is_a: GO:0005575 ! cellular_component
+disjoint_from: GO:0110165 ! cellular anatomical entity
 
 [Term]
 id: GO:0044458
@@ -32065,11 +32347,6 @@ intersection_of: GO:0065007 ! biological regulation
 intersection_of: RO:0002213 GO:0050931 ! positively regulates pigment cell differentiation
 relationship: RO:0002213 GO:0050931 ! positively regulates pigment cell differentiation
 
-[Term]
-id: GO:0050952
-name: sensory perception of electrical stimulus
-is_a: GO:0007600 ! sensory perception
-
 [Term]
 id: GO:0050953
 name: sensory perception of light stimulus
@@ -32082,13 +32359,6 @@ synonym: "mechanosensory perception" EXACT []
 synonym: "perception of mechanical stimulus" EXACT []
 is_a: GO:0007600 ! sensory perception
 
-[Term]
-id: GO:0050956
-name: electroception
-synonym: "electroception sense" EXACT []
-synonym: "electroceptive sense" EXACT []
-is_a: GO:0050952 ! sensory perception of electrical stimulus
-
 [Term]
 id: GO:0050962
 name: detection of light stimulus involved in sensory perception
@@ -32104,44 +32374,6 @@ intersection_of: GO:0009583 ! detection of light stimulus
 intersection_of: BFO:0000050 GO:0007600 ! part of sensory perception
 relationship: BFO:0000050 GO:0050953 ! part of sensory perception of light stimulus
 
-[Term]
-id: GO:0050963
-name: detection of electrical stimulus involved in sensory perception
-synonym: "sensory detection of electrical stimulus" EXACT []
-synonym: "sensory detection of electrical stimulus during sensory perception" EXACT []
-synonym: "sensory perception, sensory detection of electrical stimulus" EXACT []
-synonym: "sensory perception, sensory transduction of electrical stimulus" EXACT []
-synonym: "sensory transduction of electrical stimulus" EXACT []
-synonym: "sensory transduction of electrical stimulus during sensory perception" EXACT []
-is_a: GO:0050906 ! detection of stimulus involved in sensory perception
-is_a: GO:0050981 ! detection of electrical stimulus
-intersection_of: GO:0050981 ! detection of electrical stimulus
-intersection_of: BFO:0000050 GO:0007600 ! part of sensory perception
-relationship: BFO:0000050 GO:0050952 ! part of sensory perception of electrical stimulus
-
-[Term]
-id: GO:0050964
-name: detection of electrical stimulus involved in electroception
-synonym: "electroception, detection of electrical stimulus" EXACT []
-synonym: "electroception, sensory detection of electrical stimulus" EXACT []
-synonym: "electroception, sensory transduction" EXACT []
-synonym: "electroception, sensory transduction of electrical stimulus" EXACT []
-is_a: GO:0050963 ! detection of electrical stimulus involved in sensory perception
-intersection_of: GO:0050981 ! detection of electrical stimulus
-intersection_of: BFO:0000050 GO:0050956 ! part of electroception
-relationship: BFO:0000050 GO:0050956 ! part of electroception
-
-[Term]
-id: GO:0050967
-name: detection of electrical stimulus involved in sensory perception of pain
-synonym: "perception of pain, detection of electrical stimulus" EXACT []
-synonym: "perception of pain, sensory detection of electrical stimulus" EXACT []
-synonym: "perception of pain, sensory transduction of electrical stimulus" EXACT []
-is_a: GO:0050963 ! detection of electrical stimulus involved in sensory perception
-is_a: GO:0062149 ! detection of stimulus involved in sensory perception of pain
-intersection_of: GO:0050981 ! detection of electrical stimulus
-intersection_of: BFO:0000050 GO:0019233 ! part of sensory perception of pain
-
 [Term]
 id: GO:0050968
 name: detection of chemical stimulus involved in sensory perception of pain
@@ -32164,12 +32396,6 @@ synonym: "taction" EXACT []
 synonym: "tactition" EXACT []
 is_a: GO:0050954 ! sensory perception of mechanical stimulus
 
-[Term]
-id: GO:0050981
-name: detection of electrical stimulus
-is_a: GO:0009582 ! detection of abiotic stimulus
-is_a: GO:0051602 ! response to electrical stimulus
-
 [Term]
 id: GO:0050994
 name: regulation of lipid catabolic process
@@ -33069,11 +33295,6 @@ intersection_of: GO:0065007 ! biological regulation
 intersection_of: RO:0002213 GO:0006836 ! positively regulates neurotransmitter transport
 relationship: RO:0002213 GO:0006836 ! positively regulates neurotransmitter transport
 
-[Term]
-id: GO:0051602
-name: response to electrical stimulus
-is_a: GO:0009628 ! response to abiotic stimulus
-
 [Term]
 id: GO:0051606
 name: detection of stimulus
@@ -33234,7 +33455,7 @@ intersection_of: GO:0051234 ! establishment of localization
 intersection_of: BFO:0000066 CL:0000000 ! occurs in cell
 relationship: BFO:0000050 GO:0051641 ! part of cellular localization
 relationship: BFO:0000066 CL:0000000 ! occurs in cell
-relationship: RO:0002162 NCBITaxon:131567 ! in taxon cellular organisms
+relationship: RO:0002162 NCBITaxon:131567 ! in taxon cellular organism
 
 [Term]
 id: GO:0051650
@@ -40754,6 +40975,7 @@ synonym: "cellular anatomical entity" EXACT []
 is_a: CARO:0000000 ! anatomical entity
 is_a: GO:0005575 ! cellular_component
 is_a: UBERON:0000061 ! anatomical structure
+disjoint_from: UBERON:0000001 ! gross anatomical part
 relationship: BFO:0000051 COB:0000013 ! has part molecule
 
 [Term]
@@ -40790,6 +41012,18 @@ intersection_of: GO:0042995 ! cell projection
 intersection_of: BFO:0000051 GO:0098590 ! has part plasma membrane region
 relationship: BFO:0000051 GO:0098590 ! has part plasma membrane region
 
+[Term]
+id: GO:0120029
+name: proton export across plasma membrane
+synonym: "hydrogen ion export across plasma membrane" EXACT []
+is_a: GO:0140115 ! export across plasma membrane
+is_a: GO:1902600 ! proton transmembrane transport
+intersection_of: GO:0006810 ! transport
+intersection_of: RO:0002338 GO:0005829 ! has target start location cytosol
+intersection_of: RO:0002339 GO:0005576 ! has target end location extracellular region
+intersection_of: RO:0002342 GO:0005886 ! results in transport across plasma membrane
+intersection_of: RO:0004009 CHEBI:15378 ! has primary input hydron
+
 [Term]
 id: GO:0120031
 name: plasma membrane bounded cell projection assembly
@@ -43532,6 +43766,17 @@ intersection_of: GO:0008104 ! intracellular protein localization
 intersection_of: RO:0002339 GO:0005730 ! has target end location nucleolus
 relationship: RO:0002339 GO:0005730 ! has target end location nucleolus
 
+[Term]
+id: GO:1902600
+name: proton transmembrane transport
+synonym: "hydrogen ion transmembrane transport" EXACT []
+synonym: "hydrogen transmembrane transport" EXACT []
+is_a: GO:0098655 ! monoatomic cation transmembrane transport
+is_a: GO:0098662 ! inorganic cation transmembrane transport
+intersection_of: GO:0055085 ! transmembrane transport
+intersection_of: RO:0004009 CHEBI:15378 ! has primary input hydron
+relationship: RO:0004009 CHEBI:15378 ! has primary input hydron
+
 [Term]
 id: GO:1902679
 name: negative regulation of RNA biosynthetic process
@@ -49094,7 +49339,7 @@ is_a: IAO:0000104 ! plan specification
 
 [Term]
 id: IAO:0000027
-name: data item
+name: data entity
 def: "An information content entity that is intended to be a truthful statement about something (modulo, e.g., measurement precision or other systematic errors) and is constructed/acquired by a method which reliably tends to produce (approximately) truthful statements." []
 is_a: IAO:0000030 ! information content entity
 
@@ -49143,7 +49388,7 @@ is_a: IAO:0000033 ! directive information entity
 id: IAO:0000100
 name: data set
 def: "A data item that is an aggregate of other data items of the same type that have something in common. Averages and distributions can be determined for data sets." []
-is_a: IAO:0000027 ! data item
+is_a: IAO:0000027 ! data entity
 
 [Term]
 id: IAO:0000101
@@ -49155,7 +49400,7 @@ is_a: IAO:0000308 ! figure
 id: IAO:0000102
 name: data about an ontology part
 def: "Data about an ontology part is a data item about a part of an ontology, for example a term" []
-is_a: IAO:0000027 ! data item
+is_a: IAO:0000027 ! data entity
 
 [Term]
 id: IAO:0000104
@@ -49386,6 +49631,16 @@ id: NCBITaxon:1206795
 name: Lophotrochozoa
 is_a: NCBITaxon:2697495 ! Spiralia
 
+[Term]
+id: NCBITaxon:1224
+name: Pseudomonadota
+is_a: NCBITaxon:3379134 ! Pseudomonadati
+
+[Term]
+id: NCBITaxon:1236
+name: Gammaproteobacteria
+is_a: NCBITaxon:1224 ! Pseudomonadota
+
 [Term]
 id: NCBITaxon:124129
 name: Acipenserinae
@@ -49415,7 +49670,8 @@ disjoint_from: NCBITaxon:33511 ! Deuterostomia
 
 [Term]
 id: NCBITaxon:131567
-name: cellular organisms
+name: cellular organism
+is_a: COB:0000022 ! organism
 is_a: NCBITaxon:1 ! root
 
 [Term]
@@ -49528,7 +49784,7 @@ is_a: NCBITaxon:6656 ! Arthropoda
 [Term]
 id: NCBITaxon:2
 name: Bacteria
-is_a: NCBITaxon:131567 ! cellular organisms
+is_a: NCBITaxon:131567 ! cellular organism
 
 [Term]
 id: NCBITaxon:2058185
@@ -49548,7 +49804,7 @@ is_a: NCBITaxon:9604 ! Hominidae
 [Term]
 id: NCBITaxon:2157
 name: Archaea
-is_a: NCBITaxon:131567 ! cellular organisms
+is_a: NCBITaxon:131567 ! cellular organism
 
 [Term]
 id: NCBITaxon:2301116
@@ -49603,9 +49859,7 @@ is_a: NCBITaxon:2743709 ! Danionidae
 [Term]
 id: NCBITaxon:2759
 name: Eukaryota
-is_a: COB:0000022 ! organism
-is_a: NCBITaxon:131567 ! cellular organisms
-property_value: IAO:0000118 "eucaryotes" xsd:string
+is_a: NCBITaxon:131567 ! cellular organism
 property_value: IAO:0000118 "eukaryotes" xsd:string
 
 [Term]
@@ -49736,6 +49990,7 @@ id: NCBITaxon:33208
 name: Metazoa
 is_a: NCBITaxon:33154 ! Opisthokonta
 disjoint_from: NCBITaxon:4751 ! Fungi
+property_value: IAO:0000118 "animals" xsd:string
 property_value: IAO:0000118 "metazoans" xsd:string
 property_value: IAO:0000118 "multicellular animals" xsd:string
 
@@ -49791,6 +50046,11 @@ id: NCBITaxon:3378
 name: Gnetales
 is_a: NCBITaxon:1445966 ! Gnetidae
 
+[Term]
+id: NCBITaxon:3379134
+name: Pseudomonadati
+is_a: NCBITaxon:2 ! Bacteria
+
 [Term]
 id: NCBITaxon:3398
 name: Magnoliopsida
@@ -49968,6 +50228,11 @@ id: NCBITaxon:50557
 name: Insecta
 is_a: NCBITaxon:6960 ! Hexapoda
 
+[Term]
+id: NCBITaxon:543
+name: Enterobacteriaceae
+is_a: NCBITaxon:91347 ! Enterobacterales
+
 [Term]
 id: NCBITaxon:554915
 name: Amoebozoa
@@ -49983,6 +50248,16 @@ id: NCBITaxon:55885
 name: Peloderinae
 is_a: NCBITaxon:6243 ! Rhabditidae
 
+[Term]
+id: NCBITaxon:561
+name: Escherichia
+is_a: NCBITaxon:543 ! Enterobacteriaceae
+
+[Term]
+id: NCBITaxon:562
+name: Escherichia coli
+is_a: NCBITaxon:561 ! Escherichia
+
 [Term]
 id: NCBITaxon:5782
 name: Dictyostelium
@@ -50061,6 +50336,11 @@ id: NCBITaxon:6362
 name: Sabellida
 is_a: NCBITaxon:105391 ! Canalipalpata
 
+[Term]
+id: NCBITaxon:637912
+name: Escherichia coli OP50
+is_a: NCBITaxon:562 ! Escherichia coli
+
 [Term]
 id: NCBITaxon:6656
 name: Arthropoda
@@ -50331,6 +50611,11 @@ id: NCBITaxon:89593
 name: Craniata <chordates>
 is_a: NCBITaxon:7711 ! Chordata
 
+[Term]
+id: NCBITaxon:91347
+name: Enterobacterales
+is_a: NCBITaxon:1236 ! Gammaproteobacteria
+
 [Term]
 id: NCBITaxon:9254
 name: Prototheria
@@ -50429,11 +50714,27 @@ id: NCIT:C14376
 name: Other Organism Groupings
 is_a: NCIT:C14250 ! Organism
 
+[Term]
+id: NCIT:C16203
+name: Clinical or Research Activity
+is_a: NCIT:C43431 ! Activity
+
 [Term]
 id: NCIT:C16847
 name: Technique
 is_a: NCIT:C43431 ! Activity
 
+[Term]
+id: NCIT:C16853
+name: Microscopy
+is_a: NCIT:C17369 ! Imaging Procedure
+is_a: NCIT:C74957 ! Mixed Category Laboratory Procedure
+
+[Term]
+id: NCIT:C16856
+name: Fluorescence Microscopy
+is_a: NCIT:C17995 ! Light Microscopy
+
 [Term]
 id: NCIT:C17187
 name: Technology
@@ -50444,12 +50745,22 @@ id: NCIT:C172272
 name: Electronic File Content Type
 is_a: NCIT:C25284 ! Type
 
+[Term]
+id: NCIT:C17369
+name: Imaging Procedure
+is_a: NCIT:C25218 ! Clinical Intervention or Procedure
+
 [Term]
 id: NCIT:C179817
 name: Velocity
 is_a: NCIT:C25447 ! Characteristic
 is_a: NCIT:C70766 ! Quantitative Concept
 
+[Term]
+id: NCIT:C17995
+name: Light Microscopy
+is_a: NCIT:C16853 ! Microscopy
+
 [Term]
 id: NCIT:C18141
 name: Computer Sciences
@@ -50522,6 +50833,11 @@ id: NCIT:C25206
 name: Temperature
 is_a: NCIT:C25447 ! Characteristic
 
+[Term]
+id: NCIT:C25218
+name: Clinical Intervention or Procedure
+is_a: NCIT:C16203 ! Clinical or Research Activity
+
 [Term]
 id: NCIT:C25284
 name: Type
@@ -50532,6 +50848,11 @@ id: NCIT:C25285
 name: Diameter
 is_a: NCIT:C70766 ! Quantitative Concept
 
+[Term]
+id: NCIT:C25294
+name: Laboratory Procedure
+is_a: NCIT:C25218 ! Clinical Intervention or Procedure
+
 [Term]
 id: NCIT:C25335
 name: Volume
@@ -50647,6 +50968,11 @@ id: NCIT:C73706
 name: Spatial Qualifier
 is_a: NCIT:C41009 ! Qualifier
 
+[Term]
+id: NCIT:C74957
+name: Mixed Category Laboratory Procedure
+is_a: NCIT:C25294 ! Laboratory Procedure
+
 [Term]
 id: NCIT:C85776
 name: Optical Density Measurement
@@ -51087,9 +51413,9 @@ id: OBI:0200000
 name: data transformation
 def: "A completely executed planned process that produces output data from input data." []
 is_a: COB:0000035 ! completely executed planned process
-relationship: OBI:0000293 IAO:0000027 {all_only="true"} ! has specified input data item
-relationship: OBI:0000293 IAO:0000027 ! has specified input data item
-relationship: OBI:0000299 IAO:0000027 ! has specified output data item
+relationship: OBI:0000293 IAO:0000027 {all_only="true"} ! has specified input data entity
+relationship: OBI:0000293 IAO:0000027 ! has specified input data entity
+relationship: OBI:0000299 IAO:0000027 ! has specified output data entity
 relationship: OBI:0000417 OBI:0200166 ! achieves_planned_objective data transformation objective
 property_value: IAO:0000118 "data analysis" xsd:string
 property_value: IAO:0000118 "data processing" xsd:string
@@ -51138,8 +51464,8 @@ id: OBI:0200111
 name: data visualization
 def: "A planned process with the objective to graphically represent some data by inputing the data and outputting images, diagrams or animations." []
 is_a: COB:0000035 ! completely executed planned process
-relationship: OBI:0000293 IAO:0000027 {all_only="true"} ! has specified input data item
-relationship: OBI:0000293 IAO:0000027 ! has specified input data item
+relationship: OBI:0000293 IAO:0000027 {all_only="true"} ! has specified input data entity
+relationship: OBI:0000293 IAO:0000027 ! has specified input data entity
 property_value: IAO:0000118 "data encoding as image" xsd:string
 property_value: IAO:0000118 "visualization" xsd:string
 
@@ -53061,9 +53387,14 @@ is_a: BFO:0000040 ! material entity
 [Term]
 id: UBERON:0000000
 name: processual entity
-is_a: BFO:0000003 ! occurrent
 disjoint_from: UBERON:0001062 ! anatomical entity
 
+[Term]
+id: UBERON:0000001
+name: gross anatomical part
+is_a: UBERON:0000465 ! material anatomical entity
+disjoint_from: UBERON:0000468 ! multicellular organism
+
 [Term]
 id: UBERON:0000005
 name: chemosensory organ
@@ -53320,6 +53651,7 @@ relationship: RO:0002220 UBERON:0002553 ! adjacent to anatomical cavity
 [Term]
 id: UBERON:0000061
 name: anatomical structure
+def: "Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome." []
 synonym: "biological structure" EXACT []
 is_a: UBERON:0000465 ! material anatomical entity
 relationship: RO:0002496 UBERON:0000106 {gci_filler="NCBITaxon:33208", gci_relation="RO:0002162"} ! existence starts during or after zygote stage
@@ -53533,6 +53865,7 @@ synonym: "entire life cycle" EXACT []
 synonym: "entire lifespan" EXACT []
 synonym: "life" EXACT []
 synonym: "lifespan" EXACT []
+is_a: BFO:0000015 ! process
 is_a: UBERON:0000000 ! processual entity
 relationship: RO:0002224 UBERON:0000106 {gci_filler="NCBITaxon:33208", gci_relation="RO:0002162"} ! starts with zygote stage
 relationship: RO:0002230 UBERON:0000071 ! ends with death stage
@@ -53540,6 +53873,7 @@ relationship: RO:0002230 UBERON:0000071 ! ends with death stage
 [Term]
 id: UBERON:0000105
 name: life cycle stage
+is_a: BFO:0000015 ! process
 is_a: UBERON:0000000 ! processual entity
 relationship: BFO:0000050 UBERON:0000104 ! part of life cycle
 
@@ -53757,7 +54091,6 @@ name: proximal-distal subdivision of colon
 is_a: UBERON:0004921 ! subdivision of digestive tract
 intersection_of: UBERON:0013522 ! subdivision of tube
 intersection_of: subdivision_of UBERON:0001155 ! colon
-relationship: BFO:0000050 UBERON:0001155 ! part of colon
 relationship: subdivision_of UBERON:0001155 ! colon
 
 [Term]
@@ -54155,7 +54488,8 @@ relationship: RO:0020101 UBERON:0001675 ! vessel supplies blood to trigeminal ga
 [Term]
 id: UBERON:0000463
 name: organism substance
-is_a: UBERON:0000465 ! material anatomical entity
+is_a: UBERON:0000001 ! gross anatomical part
+disjoint_from: UBERON:0000468 ! multicellular organism
 relationship: BFO:0000050 UBERON:0000468 ! part of multicellular organism
 relationship: RO:0000086 PATO:0002198 ! has quality quality of a substance
 
@@ -54229,6 +54563,7 @@ relationship: RO:0002131 UBERON:0002416 {gci_filler="NCBITaxon:6072", gci_relati
 [Term]
 id: UBERON:0000476
 name: acellular anatomical structure
+is_a: UBERON:0000001 ! gross anatomical part
 is_a: UBERON:0000061 ! anatomical structure
 
 [Term]
@@ -63602,7 +63937,6 @@ name: subdivision of digestive tract
 is_a: UBERON:0013522 ! subdivision of tube
 intersection_of: UBERON:0013522 ! subdivision of tube
 intersection_of: subdivision_of UBERON:0001555 ! digestive tract
-relationship: BFO:0000050 UBERON:0001555 ! part of digestive tract
 relationship: subdivision_of UBERON:0001555 ! digestive tract
 
 [Term]
@@ -64375,7 +64709,7 @@ relationship: RO:0002202 UBERON:0003372 ! develops from pectoral appendage bud e
 [Term]
 id: UBERON:0005423
 name: developing anatomical structure
-is_a: UBERON:0000465 ! material anatomical entity
+is_a: UBERON:0000001 ! gross anatomical part
 relationship: RO:0002215 GO:0032502 ! capable of developmental process
 
 [Term]
@@ -65187,7 +65521,6 @@ is_a: UBERON:0006077 ! subdivision of vertebral column
 intersection_of: UBERON:0006077 ! subdivision of vertebral column
 intersection_of: subdivision_of UBERON:0006071 ! caudal region
 relationship: BFO:0000050 UBERON:0002090 ! part of postcranial axial skeleton
-relationship: BFO:0000050 UBERON:0006071 ! part of caudal region
 relationship: subdivision_of UBERON:0006071 ! caudal region
 
 [Term]
@@ -65198,7 +65531,6 @@ synonym: "vertebral series" EXACT []
 is_a: UBERON:0000075 ! subdivision of skeletal system
 intersection_of: UBERON:0000075 ! subdivision of skeletal system
 intersection_of: subdivision_of UBERON:0001130 ! vertebral column
-relationship: BFO:0000050 UBERON:0001130 ! part of vertebral column
 relationship: BFO:0000050 UBERON:0001137 ! part of dorsum
 relationship: subdivision_of UBERON:0001130 ! vertebral column
 
@@ -67532,7 +67864,6 @@ is_a: UBERON:0006077 ! subdivision of vertebral column
 intersection_of: UBERON:0006077 ! subdivision of vertebral column
 intersection_of: BFO:0000050 UBERON:0002100 ! part of trunk
 intersection_of: subdivision_of UBERON:0002100 ! trunk
-relationship: BFO:0000050 UBERON:0002100 ! part of trunk
 relationship: subdivision_of UBERON:0002100 ! trunk
 
 [Term]
@@ -68862,16 +69193,6 @@ is_a: UBERON:0010498 ! pseudostratified columnar epithelium
 intersection_of: UBERON:0010498 ! pseudostratified columnar epithelium
 intersection_of: BFO:0000051 CL:0000067 ! has part ciliated epithelial cell
 
-[Term]
-id: UBERON:0010521
-name: electroreceptor organ
-synonym: "electric sense organ" EXACT []
-synonym: "electroreception organ" EXACT []
-is_a: UBERON:0000020 ! sense organ
-intersection_of: UBERON:0000062 ! organ
-intersection_of: RO:0002215 GO:0050964 ! capable of detection of electrical stimulus involved in electroception
-relationship: RO:0002215 GO:0050964 ! capable of detection of electrical stimulus involved in electroception
-
 [Term]
 id: UBERON:0010522
 name: replacement element
@@ -70299,7 +70620,6 @@ relationship: RO:0002221 UBERON:0000468 ! surrounds multicellular organism
 id: UBERON:0013522
 name: subdivision of tube
 is_a: UBERON:0000064 ! organ part
-relationship: BFO:0000050 UBERON:0000025 ! part of tube
 relationship: BFO:0000051 UBERON:0000060 ! has part anatomical wall
 relationship: BFO:0000051 UBERON:0000464 ! has part anatomical space
 relationship: subdivision_of UBERON:0000025 ! tube
@@ -72479,7 +72799,7 @@ relationship: RO:0002176 UBERON:0001159 ! connects sigmoid colon
 [Term]
 id: UBERON:0036215
 name: anatomical surface region
-is_a: UBERON:0000465 ! material anatomical entity
+is_a: UBERON:0000001 ! gross anatomical part
 relationship: RO:0002007 UBERON:0000061 ! bounding layer of anatomical structure
 
 [Term]
@@ -73293,6 +73613,14 @@ intersection_of: UBERON:0000030 ! lamina propria
 intersection_of: BFO:0000050 UBERON:0001052 ! part of rectum
 relationship: BFO:0000050 UBERON:0001052 ! part of rectum
 
+[Term]
+id: UBERON:8850001
+name: epithelium of anorectum
+is_a: UBERON:0001278 ! epithelium of large intestine
+intersection_of: UBERON:0000483 ! epithelium
+intersection_of: BFO:0000050 UBERON:8410050 ! part of anorectum
+relationship: BFO:0000050 UBERON:8410050 ! part of anorectum
+
 [Term]
 id: UO:0000001
 name: length unit
@@ -74088,7 +74416,7 @@ inverse_of: RO:0002336 ! positively regulated by
 [Typedef]
 id: RO:0002215
 name: capable of
-def: "A relation between a material entity (such as a cell) and a process, in which the material entity has the ability to carry out the process. " []
+def: "A relation between a material entity (such as a cell) and a process, in which the material entity has the ability to carry out the process." []
 property_value: IAO:0000118 "has function realized in" xsd:string
 domain: BFO:0000004 ! independent continuant
 range: BFO:0000015 ! process
@@ -75282,6 +75610,59 @@ name: device utilizes material
 def: "X device utilizes material Y means X and Y are material entities, and X is capable of some process P that has input Y." []
 holds_over_chain: RO:0002215 RO:0002233
 
+[Typedef]
+id: RO:0018030
+name: chemical relationship
+
+[Typedef]
+id: RO:0018033
+name: is deprotonated form of
+def: "A is a deprotonated form of B if and only if A is chemical entity that is a Brønsted–Lowry Base (i.e., can receive a proton) and by adding some nonzero number of protons transforms it into B.\n\nThis is a transitive relationship and follows this design pattern: https://oborel.github.io/obo-relations/direct-and-indirect-relations." []
+is_transitive: true
+is_a: RO:0018030 ! chemical relationship
+inverse_of: RO:0018034 ! is protonated form of
+
+[Typedef]
+id: RO:0018034
+name: is protonated form of
+def: "A is a protonated form of B if and only if A is chemical entity that is a Brønsted–Lowry Acid (i.e., can give up a proton) and by removing some nonzero number of protons transforms it into B.\n\nThis is a transitive relationship and follows this design pattern: https://oborel.github.io/obo-relations/direct-and-indirect-relations." []
+is_transitive: true
+is_a: RO:0018030 ! chemical relationship
+
+[Typedef]
+id: RO:0018036
+name: is tautomer of
+def: "Two chemicals are tautomers if they can be readily interconverted.\n\nThis commonly refers to prototropy in which a hydrogen's position is changed, such as between ketones and enols. This is also often observed in heterocyclic rings, e.g., ones containing nitrogens and/or have aryl functional groups containing heteroatoms." []
+synonym: "is desmotrope of" EXACT []
+is_symmetric: true
+is_a: RO:0018030 ! chemical relationship
+
+[Typedef]
+id: RO:0018037
+name: is substitutent group from
+def: "Group A is a substituent group from Chemical B if A represents the functional part of A and includes information about where it is connected. A is not itself a chemical with a fully formed chemical graph, but is rather a partial graph with one or more connection points that can be used to attach to another chemical graph, typically as a functionalization." []
+is_a: RO:0018030 ! chemical relationship
+
+[Typedef]
+id: RO:0018038
+name: has functional parent
+def: "Chemical A has functional parent Chemical B if there is chemical transformation through which chemical B can be produced from chemical A. \n\nFor example, the relationship between a salt and a freebased compound is a \"has functional parent\" relationship." []
+is_a: RO:0018030 ! chemical relationship
+
+[Typedef]
+id: RO:0018039
+name: is enantiomer of
+def: "Chemicals A and B are enantiomers if they share the same molecular graph except the change of the configuration of substituents around exactly one chiral center.\n\nA chemical with no chiral centers can not have an enantiomer. A chemical with multiple chiral centers can have multiple enantiomers, but its enantiomers are not themselves enantiomers (they are diastereomers)." []
+synonym: "is optical isomer of" EXACT []
+is_symmetric: true
+is_a: RO:0018030 ! chemical relationship
+
+[Typedef]
+id: RO:0018040
+name: has parent hydride
+def: "Chemical A has parent hydride Chemical B if there exists a molecular graphical transformation where functional groups on A are replaced with hydrogens in order to yield B." []
+is_a: RO:0018030 ! chemical relationship
+
 [Typedef]
 id: RO:0019000
 name: regulates characteristic
@@ -75420,6 +75801,7 @@ def: "c site_of p if c is the bearer of a disposition that is realized by a proc
 [Typedef]
 id: subdivision_of
 name: subdivision of
+is_a: BFO:0000050 ! part of
 
 [Typedef]
 id: transitively_anteriorly_connected_to
diff --git a/empty.owl b/empty.owl
index 8dd0645..00c938d 100644
--- a/empty.owl
+++ b/empty.owl
@@ -13,12 +13,12 @@
      xmlns:dcterms="http://purl.org/dc/terms/"
      xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#">
     <owl:Ontology rdf:about="http://purl.obolibrary.org/obo/empty.owl">
-        <owl:versionIRI rdf:resource="http://purl.obolibrary.org/obo/empty/releases/2026-02-23/empty.owl"/>
+        <owl:versionIRI rdf:resource="http://purl.obolibrary.org/obo/empty/releases/2026-04-04/empty.owl"/>
         <dcterms:description>An ontology of experimental measurements in the sciences, the purposes for which experimental measurements were made, and experimental treatments, with a focus on life sciences.</dcterms:description>
         <dcterms:license rdf:resource="https://creativecommons.org/licenses/by/4.0/"/>
         <dcterms:title>Experimental Measurements Purposes and Treatments ontologY</dcterms:title>
         <rdfs:comment>EMPTY by NDI is licensed under CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/). You are free to share (copy and redistribute the material in any medium or format) and adapt (remix, transform, and build upon the material) for any purpose, even commercially. You must give appropriate credit (by using the original ontology IRI for the whole ontology or original term IRIs for individual terms), provide a link to the license, and indicate if any changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.</rdfs:comment>
-        <owl:versionInfo>2026-02-23</owl:versionInfo>
+        <owl:versionInfo>2026-04-04</owl:versionInfo>
         <owl:versionInfo>Release 2025-07-10</owl:versionInfo>
     </owl:Ontology>
     
@@ -38,8 +38,11 @@
     <!-- http://purl.obolibrary.org/obo/IAO_0000115 -->
 
     <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000115">
+        <obo:IAO_0000115>A property representing the English language definitions of what NCI means by the concept. They may also include information about the definition&apos;s source and attribution in a form that can easily be interpreted by software.</obo:IAO_0000115>
+        <obo:IAO_0000115>English language definitions of what NCI means by the concept. These are limited to 1024 characters. They may also include information about the definition&apos;s source and attribution in a form that can easily be interpreted by software.</obo:IAO_0000115>
         <obo:IAO_0000115 xml:lang="en">The official OBI definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions.</obo:IAO_0000115>
         <obo:IAO_0000115 xml:lang="en">The official definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions.</obo:IAO_0000115>
+        <obo:IAO_0000115>The official definition.</obo:IAO_0000115>
         <rdfs:label>definition</rdfs:label>
         <rdfs:label xml:lang="en">definition</rdfs:label>
         <rdfs:label>textual definition</rdfs:label>
@@ -1527,6 +1530,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.</obo:I
         <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002216"/>
         <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000004"/>
         <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
+        <obo:IAO_0000115>A relation between a material entity (such as a cell) and a process, in which the material entity has the ability to carry out the process.</obo:IAO_0000115>
         <obo:IAO_0000115>A relation between a material entity (such as a cell) and a process, in which the material entity has the ability to carry out the process. </obo:IAO_0000115>
         <obo:IAO_0000118>has function realized in</obo:IAO_0000118>
         <rdfs:label>capable of</rdfs:label>
@@ -3628,6 +3632,101 @@ For example, A and B may be gene products and binding of B by A positively regul
     
 
 
+    <!-- http://purl.obolibrary.org/obo/RO_0018030 -->
+
+    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0018030">
+        <rdfs:label>chemical relationship</rdfs:label>
+    </owl:ObjectProperty>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/RO_0018033 -->
+
+    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0018033">
+        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0018030"/>
+        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
+        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#TransitiveProperty"/>
+        <obo:IAO_0000115>A is a deprotonated form of B if and only if A is chemical entity that is a Brønsted–Lowry Base (i.e., can receive a proton) and by adding some nonzero number of protons transforms it into B.
+
+This is a transitive relationship and follows this design pattern: https://oborel.github.io/obo-relations/direct-and-indirect-relations.</obo:IAO_0000115>
+        <rdfs:label>is deprotonated form of</rdfs:label>
+    </owl:ObjectProperty>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/RO_0018034 -->
+
+    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0018034">
+        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0018030"/>
+        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#TransitiveProperty"/>
+        <obo:IAO_0000115>A is a protonated form of B if and only if A is chemical entity that is a Brønsted–Lowry Acid (i.e., can give up a proton) and by removing some nonzero number of protons transforms it into B.
+
+This is a transitive relationship and follows this design pattern: https://oborel.github.io/obo-relations/direct-and-indirect-relations.</obo:IAO_0000115>
+        <rdfs:label>is protonated form of</rdfs:label>
+    </owl:ObjectProperty>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/RO_0018036 -->
+
+    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0018036">
+        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0018030"/>
+        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#SymmetricProperty"/>
+        <obo:IAO_0000115>Two chemicals are tautomers if they can be readily interconverted.
+
+This commonly refers to prototropy in which a hydrogen&apos;s position is changed, such as between ketones and enols. This is also often observed in heterocyclic rings, e.g., ones containing nitrogens and/or have aryl functional groups containing heteroatoms.</obo:IAO_0000115>
+        <oboInOwl:hasExactSynonym>is desmotrope of</oboInOwl:hasExactSynonym>
+        <rdfs:label xml:lang="en">is tautomer of</rdfs:label>
+    </owl:ObjectProperty>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/RO_0018037 -->
+
+    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0018037">
+        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0018030"/>
+        <obo:IAO_0000115>Group A is a substituent group from Chemical B if A represents the functional part of A and includes information about where it is connected. A is not itself a chemical with a fully formed chemical graph, but is rather a partial graph with one or more connection points that can be used to attach to another chemical graph, typically as a functionalization.</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">is substitutent group from</rdfs:label>
+    </owl:ObjectProperty>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/RO_0018038 -->
+
+    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0018038">
+        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0018030"/>
+        <obo:IAO_0000115>Chemical A has functional parent Chemical B if there is chemical transformation through which chemical B can be produced from chemical A. 
+
+For example, the relationship between a salt and a freebased compound is a &quot;has functional parent&quot; relationship.</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">has functional parent</rdfs:label>
+    </owl:ObjectProperty>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/RO_0018039 -->
+
+    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0018039">
+        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0018030"/>
+        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#SymmetricProperty"/>
+        <obo:IAO_0000115>Chemicals A and B are enantiomers if they share the same molecular graph except the change of the configuration of substituents around exactly one chiral center.
+
+A chemical with no chiral centers can not have an enantiomer. A chemical with multiple chiral centers can have multiple enantiomers, but its enantiomers are not themselves enantiomers (they are diastereomers).</obo:IAO_0000115>
+        <oboInOwl:hasExactSynonym>is optical isomer of</oboInOwl:hasExactSynonym>
+        <rdfs:label xml:lang="en">is enantiomer of</rdfs:label>
+    </owl:ObjectProperty>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/RO_0018040 -->
+
+    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0018040">
+        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0018030"/>
+        <obo:IAO_0000115>Chemical A has parent hydride Chemical B if there exists a molecular graphical transformation where functional groups on A are replaced with hydrogens in order to yield B.</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">has parent hydride</rdfs:label>
+    </owl:ObjectProperty>
+    
+
+
     <!-- http://purl.obolibrary.org/obo/RO_0019000 -->
 
     <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0019000">
@@ -3760,12 +3859,6 @@ For example, A and B may be gene products and binding of B by A positively regul
     
 
 
-    <!-- http://purl.obolibrary.org/obo/chebi#is_enantiomer_of -->
-
-    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/chebi#is_enantiomer_of"/>
-    
-
-
     <!-- http://purl.obolibrary.org/obo/chebi#is_substituent_group_from -->
 
     <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/chebi#is_substituent_group_from"/>
@@ -3928,6 +4021,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <!-- http://purl.obolibrary.org/obo/uberon/core#subdivision_of -->
 
     <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/uberon/core#subdivision_of">
+        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
         <rdfs:label>subdivision of</rdfs:label>
     </owl:ObjectProperty>
     
@@ -4183,6 +4277,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_10545">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_36338"/>
         <obo:IAO_0000115>Elementary particle not affected by the strong force having a spin 1/2, a negative elementary charge and a rest mass of 0.000548579903(13) u, or 0.51099906(15) MeV.</obo:IAO_0000115>
+        <obo:IAO_0000115>Elementary particle not affected by the strong force having a spin ½, a negative elementary charge and a rest mass of 0.000548579903(13) u, or 0.51099906(15) MeV.</obo:IAO_0000115>
         <rdfs:label>electron</rdfs:label>
     </owl:Class>
     
@@ -4192,7 +4287,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_131604">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_76969"/>
-        <obo:IAO_0000115>Any bacterial metabolite produced during a metabolic reaction in Mycoplasma genitalium.</obo:IAO_0000115>
+        <obo:IAO_0000115>Any bacterial metabolite produced during a metabolic reaction in &lt;em&gt;Mycoplasma genitalium&lt;/em&gt;.</obo:IAO_0000115>
         <rdfs:label>Mycoplasma genitalium metabolite</rdfs:label>
     </owl:Class>
     
@@ -4213,6 +4308,12 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_132153">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_61469"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_63551"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_16336"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of"/>
@@ -4229,7 +4330,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_136889">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35341"/>
-        <obo:IAO_0000115>Any steroid that has beta-configuration at position 5.</obo:IAO_0000115>
+        <obo:IAO_0000115>Any steroid that has β-configuration at position 5.</obo:IAO_0000115>
         <rdfs:label>5beta steroid</rdfs:label>
     </owl:Class>
     
@@ -4240,6 +4341,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_138103">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_39141"/>
         <obo:IAO_0000115>A Bronsted acid derived from one or more inorganic compounds. Inorganic acids (also known as mineral acids) form hydrons and conjugate base ions when dissolved in water.</obo:IAO_0000115>
+        <obo:IAO_0000115>A Brønsted acid derived from one or more inorganic compounds. Inorganic acids (also known as mineral acids) form hydrons and conjugate base ions when dissolved in water.</obo:IAO_0000115>
         <rdfs:label>inorganic acid</rdfs:label>
     </owl:Class>
     
@@ -4251,7 +4353,7 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_25384"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35350"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_36078"/>
-        <obo:IAO_0000115>Any member of a group of hydroxy steroids occuring in bile, where they are present as the sodium salts of their amides with glycine or taurine. In mammals bile acids almost invariably have 5beta-configuration, while in lower vertebrates, some bile acids, known as allo-bile acids, have 5alpha-configuration.</obo:IAO_0000115>
+        <obo:IAO_0000115>Any member of a group of hydroxy steroids occuring in bile, where they are present as the sodium salts of their amides with glycine or taurine. In mammals bile acids almost invariably have 5β-configuration, while in lower vertebrates, some bile acids, known as &lt;i&gt;allo&lt;/i&gt;-bile acids, have 5α-configuration.</obo:IAO_0000115>
         <rdfs:label>bile acids</rdfs:label>
     </owl:Class>
     
@@ -4262,6 +4364,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_138675">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33579"/>
         <obo:IAO_0000115>Any main group molecular entity that is gaseous at standard temperature and pressure (STP; 0degreeC and 100 kPa).</obo:IAO_0000115>
+        <obo:IAO_0000115>Any main group molecular entity that is gaseous at standard temperature and pressure (STP; 0°C and 100 kPa).</obo:IAO_0000115>
         <rdfs:label>gas molecular entity</rdfs:label>
     </owl:Class>
     
@@ -4271,6 +4374,12 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_13941">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_37022"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_28616"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of"/>
@@ -4288,7 +4397,7 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_26666"/>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_78115"/>
             </owl:Restriction>
         </rdfs:subClassOf>
@@ -4308,7 +4417,7 @@ For example, A and B may be gene products and binding of B by A positively regul
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_53000"/>
             </owl:Restriction>
         </rdfs:subClassOf>
-        <obo:IAO_0000115>An antigenic epitope recognized by an anti-bilirubin monoclonal antibody designated 24G7. A substructure of bilirubin IXalpha, it is the region containing the oxo group at C-1, the methyl group at C-2, C-(4, 5, 6, 9), and N-21 and -22.</obo:IAO_0000115>
+        <obo:IAO_0000115>An antigenic epitope recognized by an anti-bilirubin monoclonal antibody designated 24G7. A substructure of bilirubin IXα, it is the region containing the oxo group at C-1, the methyl group at C-2, C-(4, 5, 6, 9), and N-21 and -22.</obo:IAO_0000115>
         <rdfs:label>24G7 epitope</rdfs:label>
     </owl:Class>
     
@@ -4326,17 +4435,17 @@ For example, A and B may be gene products and binding of B by A positively regul
         </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
-                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_29987"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_18237"/>
             </owl:Restriction>
         </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of"/>
-                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_18237"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_29987"/>
             </owl:Restriction>
         </rdfs:subClassOf>
-        <obo:IAO_0000115>An alpha-amino-acid anion that is the conjugate base of glutamic acid, having anionic carboxy groups and a cationic amino group</obo:IAO_0000115>
+        <obo:IAO_0000115>An α-amino-acid anion that is the conjugate base of glutamic acid, having anionic carboxy groups and a cationic amino group</obo:IAO_0000115>
         <rdfs:label>glutamate(1-)</rdfs:label>
     </owl:Class>
     
@@ -4427,6 +4536,12 @@ For example, A and B may be gene products and binding of B by A positively regul
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_83056"/>
             </owl:Restriction>
         </rdfs:subClassOf>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_30089"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
@@ -4439,6 +4554,19 @@ For example, A and B may be gene products and binding of B by A positively regul
     
 
 
+    <!-- http://purl.obolibrary.org/obo/CHEBI_15378 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_15378">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_25414"/>
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33251"/>
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33252"/>
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_60242"/>
+        <obo:IAO_0000115>The general name for the hydrogen nucleus, to be used without regard to the hydrogen nuclear mass (either for hydrogen in its natural abundance or where it is not desired to distinguish between the isotopes).</obo:IAO_0000115>
+        <rdfs:label>hydron</rdfs:label>
+    </owl:Class>
+    
+
+
     <!-- http://purl.obolibrary.org/obo/CHEBI_15379 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_15379">
@@ -4487,6 +4615,12 @@ For example, A and B may be gene products and binding of B by A positively regul
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_77974"/>
             </owl:Restriction>
         </rdfs:subClassOf>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_29793"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of"/>
@@ -4502,7 +4636,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_15693">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35381"/>
-        <obo:IAO_0000115>Aldehydic parent sugars (polyhydroxy aldehydes H[CH(OH)]nC(=O)H, n &gt;= 2) and their intramolecular hemiacetals.</obo:IAO_0000115>
+        <obo:IAO_0000115>Aldehydic parent sugars (polyhydroxy aldehydes H[CH(OH)]&lt;small&gt;&lt;sub&gt;&lt;em&gt;n&lt;/em&gt;&lt;/sub&gt;&lt;/small&gt;C(=O)H, &lt;em&gt;n&lt;/em&gt; ≥ 2) and their intramolecular hemiacetals.</obo:IAO_0000115>
         <rdfs:label>aldose</rdfs:label>
     </owl:Class>
     
@@ -4514,17 +4648,17 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33704"/>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_59814"/>
             </owl:Restriction>
         </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_tautomer_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018036"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_59869"/>
             </owl:Restriction>
         </rdfs:subClassOf>
-        <obo:IAO_0000115>Any alpha-amino acid having L-configuration at the alpha-carbon.</obo:IAO_0000115>
+        <obo:IAO_0000115>Any α-amino acid having &lt;small&gt;L&lt;/small&gt;-configuration at the α-carbon.</obo:IAO_0000115>
         <rdfs:label>L-alpha-amino acid</rdfs:label>
     </owl:Class>
     
@@ -4559,17 +4693,17 @@ For example, A and B may be gene products and binding of B by A positively regul
         </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_29986"/>
             </owl:Restriction>
         </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_enantiomer_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018039"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_16015"/>
             </owl:Restriction>
         </rdfs:subClassOf>
-        <obo:IAO_0000115>An optically active form of glutamic acid having D-configuration.</obo:IAO_0000115>
+        <obo:IAO_0000115>An optically active form of glutamic acid having &lt;small&gt;D&lt;/small&gt;-configuration.</obo:IAO_0000115>
         <rdfs:label>D-glutamic acid</rdfs:label>
     </owl:Class>
     
@@ -4635,17 +4769,17 @@ For example, A and B may be gene products and binding of B by A positively regul
         </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_29985"/>
             </owl:Restriction>
         </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_enantiomer_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018039"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_15966"/>
             </owl:Restriction>
         </rdfs:subClassOf>
-        <obo:IAO_0000115>An optically active form of glutamic acid having L-configuration.</obo:IAO_0000115>
+        <obo:IAO_0000115>An optically active form of glutamic acid having &lt;small&gt;L&lt;/small&gt;-configuration.</obo:IAO_0000115>
         <rdfs:label>L-glutamic acid</rdfs:label>
     </owl:Class>
     
@@ -4693,6 +4827,18 @@ For example, A and B may be gene products and binding of B by A positively regul
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_78433"/>
             </owl:Restriction>
         </rdfs:subClassOf>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_28938"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_29337"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
@@ -4735,6 +4881,12 @@ For example, A and B may be gene products and binding of B by A positively regul
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_77746"/>
             </owl:Restriction>
         </rdfs:subClassOf>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_45696"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of"/>
@@ -4758,12 +4910,19 @@ For example, A and B may be gene products and binding of B by A positively regul
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_77746"/>
             </owl:Restriction>
         </rdfs:subClassOf>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_132153"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_132153"/>
             </owl:Restriction>
         </rdfs:subClassOf>
+        <obo:IAO_0000115>A mucopolysaccharide composed of &lt;em&gt;N&lt;/em&gt;-acetylglucosamine and glucuronic acid subunits. It is found in the connective tissues of vertebrates. A principal constituent of the extracellular matrix (ECM), it mediates the growth and metastasis of tumour cells.</obo:IAO_0000115>
         <obo:IAO_0000115>A mucopolysaccharide composed of N-acetylglucosamine and glucuronic acid subunits. It is found in the connective tissues of vertebrates. A principal constituent of the extracellular matrix (ECM), it mediates the growth and metastasis of tumour cells.</obo:IAO_0000115>
         <rdfs:label>hyaluronic acid</rdfs:label>
     </owl:Class>
@@ -4790,6 +4949,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_16646">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_78616"/>
+        <obo:IAO_0000115>Any member of the class of organooxygen compounds that is a polyhydroxy-aldehyde or -ketone or a lactol resulting from their intramolecular condensation (monosaccharides); substances derived from these by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom; and polymeric products arising by intermolecular acetal formation between two or more such molecules (disaccharides, polysaccharides and oligosaccharides). Carbohydrates contain only carbon, hydrogen and oxygen atoms; prior to any oxidation or reduction, most have the empirical formula C&lt;small&gt;&lt;sub&gt;&lt;em&gt;m&lt;/em&gt;&lt;/sub&gt;&lt;/small&gt;(H&lt;small&gt;&lt;sub&gt;2&lt;/sub&gt;&lt;/small&gt;O)&lt;small&gt;&lt;sub&gt;&lt;em&gt;n&lt;/em&gt;&lt;/sub&gt;&lt;/small&gt;. Compounds obtained from carbohydrates by substitution, etc., are known as carbohydrate derivatives and may contain other elements. Cyclitols are generally not regarded as carbohydrates.</obo:IAO_0000115>
         <obo:IAO_0000115>Any member of the class of organooxygen compounds that is a polyhydroxy-aldehyde or -ketone or a lactol resulting from their intramolecular condensation (monosaccharides); substances derived from these by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom; and polymeric products arising by intermolecular acetal formation between two or more such molecules (disaccharides, polysaccharides and oligosaccharides). Carbohydrates contain only carbon, hydrogen and oxygen atoms; prior to any oxidation or reduction, most have the empirical formula Cm(H2O)n. Compounds obtained from carbohydrates by substitution, etc., are known as carbohydrate derivatives and may contain other elements. Cyclitols are generally not regarded as carbohydrates.</obo:IAO_0000115>
         <rdfs:label>carbohydrate</rdfs:label>
     </owl:Class>
@@ -4808,6 +4968,12 @@ For example, A and B may be gene products and binding of B by A positively regul
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33708"/>
             </owl:Restriction>
         </rdfs:subClassOf>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018036"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_60466"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_tautomer_of"/>
@@ -4828,10 +4994,11 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35274"/>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33569"/>
             </owl:Restriction>
         </rdfs:subClassOf>
+        <obo:IAO_0000115>An organic cation that is the conjugate acid of noradrenaline, obtained by protonation of the primary amino group; major species at pH 7.3.</obo:IAO_0000115>
         <rdfs:label>noradrenaline(1+)</rdfs:label>
     </owl:Class>
     
@@ -4843,13 +5010,13 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_83925"/>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_60895"/>
             </owl:Restriction>
         </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_tautomer_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018036"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_59871"/>
             </owl:Restriction>
         </rdfs:subClassOf>
@@ -4862,6 +5029,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_167559">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_78616"/>
+        <obo:IAO_0000115>Any oligosaccharide, polysaccharide or their derivatives consisting of monosaccharides or monosaccharide derivatives linked by glycosidic bonds. See also &lt;a href=&quot;http://www.ontobee.org/ontology/GNO?iri=http://purl.obolibrary.org/obo/GNO_00000001&quot; target=&quot;_blank&quot;&gt;http://www.ontobee.org/ontology/GNO?iri=http://purl.obolibrary.org/obo/GNO_00000001&lt;/a&gt;.</obo:IAO_0000115>
         <obo:IAO_0000115>Any oligosaccharide, polysaccharide or their derivatives consisting of monosaccharides or monosaccharide derivatives linked by glycosidic bonds. See also http://www.ontobee.org/ontology/GNO?iri=http://purl.obolibrary.org/obo/GNO_00000001.</obo:IAO_0000115>
         <rdfs:label>glycan</rdfs:label>
     </owl:Class>
@@ -4893,6 +5061,12 @@ For example, A and B may be gene products and binding of B by A positively regul
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_77746"/>
             </owl:Restriction>
         </rdfs:subClassOf>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_57887"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of"/>
@@ -4936,23 +5110,23 @@ For example, A and B may be gene products and binding of B by A positively regul
         </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#has_functional_parent"/>
-                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_30772"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_30566"/>
             </owl:Restriction>
         </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
-                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_30566"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018036"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_59888"/>
             </owl:Restriction>
         </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_tautomer_of"/>
-                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_59888"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018038"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_30772"/>
             </owl:Restriction>
         </rdfs:subClassOf>
-        <obo:IAO_0000115>A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.</obo:IAO_0000115>
+        <obo:IAO_0000115>A γ-amino acid that is butanoic acid with the amino substituent located at C-4.</obo:IAO_0000115>
         <rdfs:label>gamma-aminobutyric acid</rdfs:label>
     </owl:Class>
     
@@ -4989,7 +5163,7 @@ For example, A and B may be gene products and binding of B by A positively regul
         </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_57977"/>
             </owl:Restriction>
         </rdfs:subClassOf>
@@ -5003,7 +5177,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_17087">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_36586"/>
-        <obo:IAO_0000115>A compound in which a carbonyl group is bonded to two carbon atoms: R2C=O (neither R may be H).</obo:IAO_0000115>
+        <obo:IAO_0000115>A compound in which a carbonyl group is bonded to two carbon atoms: R&lt;small&gt;&lt;sub&gt;2&lt;/sub&gt;&lt;/small&gt;C=O (neither R may be H).</obo:IAO_0000115>
         <rdfs:label>ketone</rdfs:label>
     </owl:Class>
     
@@ -5082,14 +5256,14 @@ For example, A and B may be gene products and binding of B by A positively regul
         </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
-                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_41609"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_28976"/>
             </owl:Restriction>
         </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of"/>
-                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_28976"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_41609"/>
             </owl:Restriction>
         </rdfs:subClassOf>
         <obo:IAO_0000115>The carbon oxoanion resulting from the removal of a proton from carbonic acid.</obo:IAO_0000115>
@@ -5103,7 +5277,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_17608">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33917"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_4194"/>
-        <obo:IAO_0000115>Any D-aldose having a chain of six carbon atoms in the molecule.</obo:IAO_0000115>
+        <obo:IAO_0000115>Any &lt;small&gt;D&lt;/small&gt;-aldose having a chain of six carbon atoms in the molecule.</obo:IAO_0000115>
         <rdfs:label>D-aldohexose</rdfs:label>
     </owl:Class>
     
@@ -5114,7 +5288,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_17634">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_17234"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_17608"/>
-        <obo:IAO_0000115>A glucose with D-configuration.</obo:IAO_0000115>
+        <obo:IAO_0000115>A glucose with &lt;small&gt;D&lt;/small&gt;-configuration.</obo:IAO_0000115>
         <rdfs:label>D-glucose</rdfs:label>
     </owl:Class>
     
@@ -5158,7 +5332,7 @@ For example, A and B may be gene products and binding of B by A positively regul
         </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_30772"/>
             </owl:Restriction>
         </rdfs:subClassOf>
@@ -5229,11 +5403,11 @@ For example, A and B may be gene products and binding of B by A positively regul
         </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_14321"/>
             </owl:Restriction>
         </rdfs:subClassOf>
-        <obo:IAO_0000115>An alpha-amino acid that is glutaric acid bearing a single amino substituent at position 2.</obo:IAO_0000115>
+        <obo:IAO_0000115>An α-amino acid that is glutaric acid bearing a single amino substituent at position 2.</obo:IAO_0000115>
         <rdfs:label>glutamic acid</rdfs:label>
     </owl:Class>
     
@@ -5285,17 +5459,17 @@ For example, A and B may be gene products and binding of B by A positively regul
         </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_72587"/>
             </owl:Restriction>
         </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_enantiomer_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018039"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33571"/>
             </owl:Restriction>
         </rdfs:subClassOf>
-        <obo:IAO_0000115>The R-enantiomer of noradrenaline.</obo:IAO_0000115>
+        <obo:IAO_0000115>The &lt;i&gt;R&lt;/i&gt;-enantiomer of noradrenaline.</obo:IAO_0000115>
         <rdfs:label>(R)-noradrenaline</rdfs:label>
     </owl:Class>
     
@@ -5314,6 +5488,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_22221">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33247"/>
+        <obo:IAO_0000115>An organic group formed by removing one or more hydroxy groups from an oxoacid that has the general structure R&lt;small&gt;&lt;sub&gt;&lt;em&gt;k&lt;/em&gt;&lt;/sub&gt;&lt;/small&gt;E(=O)&lt;small&gt;&lt;sub&gt;&lt;em&gt;l&lt;/em&gt;&lt;/sub&gt;&lt;/small&gt;(OH)&lt;small&gt;&lt;sub&gt;&lt;em&gt;m&lt;/em&gt;&lt;/sub&gt;&lt;/small&gt; (&lt;em&gt;l&lt;/em&gt; ≠ 0). Although the term is almost always applied to organic compounds, with carboxylic acid as the oxoacid, acyl groups can in principle be derived from other types of acids such as sulfonic acids or phosphonic acids.</obo:IAO_0000115>
         <obo:IAO_0000115>An organic group formed by removing one or more hydroxy groups from an oxoacid that has the general structure RkE(=O)l(OH)m (l =/= 0). Although the term is almost always applied to organic compounds, with carboxylic acid as the oxoacid, acyl groups can in principle be derived from other types of acids such as sulfonic acids or phosphonic acids.</obo:IAO_0000115>
         <rdfs:label>acyl group</rdfs:label>
     </owl:Class>
@@ -5382,6 +5557,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_22695">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_51086"/>
         <obo:IAO_0000115>A molecular entity having an available pair of electrons capable of forming a covalent bond with a hydron (Bronsted base) or with the vacant orbital of some other molecular entity (Lewis base).</obo:IAO_0000115>
+        <obo:IAO_0000115>A molecular entity having an available pair of electrons capable of forming a covalent bond with a hydron (Brønsted base) or with the vacant orbital of some other molecular entity (Lewis base).</obo:IAO_0000115>
         <rdfs:label>base</rdfs:label>
     </owl:Class>
     
@@ -5404,6 +5580,7 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33232"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_51086"/>
         <obo:IAO_0000115>Any compound that produces a peak used as reference frequency in the delta chemical shift scale.</obo:IAO_0000115>
+        <obo:IAO_0000115>Any compound that produces a peak used as reference frequency in the δ chemical shift scale.</obo:IAO_0000115>
         <rdfs:label>NMR chemical shift reference compound</rdfs:label>
     </owl:Class>
     
@@ -5424,6 +5601,12 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_23004">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_27207"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018037"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_28616"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_substituent_group_from"/>
@@ -5465,6 +5648,28 @@ For example, A and B may be gene products and binding of B by A positively regul
     
 
 
+    <!-- http://purl.obolibrary.org/obo/CHEBI_234420 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_234420">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_166902"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33571"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018039"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_72587"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
+        <obo:IAO_0000115>An organic cation that is the conjugate acid of (&lt;i&gt;S&lt;/i&gt;)-noradrenaline, obtained by protonation of the primary amino group; major species at pH 7.3.</obo:IAO_0000115>
+        <rdfs:label>(S)-noradrenaline(1+)</rdfs:label>
+    </owl:Class>
+    
+
+
     <!-- http://purl.obolibrary.org/obo/CHEBI_23449 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_23449">
@@ -5510,7 +5715,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_24318">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_15705"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_83813"/>
-        <obo:IAO_0000115>An L-alpha-amino acid which is L-glutamic acid or any of the essential amino acids biosynthesised from it (glutamine, proline and arginine). A closed class.</obo:IAO_0000115>
+        <obo:IAO_0000115>An &lt;small&gt;L&lt;/small&gt;-α-amino acid which is &lt;small&gt;L&lt;/small&gt;-glutamic acid or any of the essential amino acids biosynthesised from it (glutamine, proline and arginine). A closed class.</obo:IAO_0000115>
         <rdfs:label>glutamine family amino acid</rdfs:label>
     </owl:Class>
     
@@ -5520,7 +5725,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_24319">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_76823"/>
-        <obo:IAO_0000115>An EC 6.3.* (C-N bond-forming ligase) inhibitor that interferes with the action of glutamate--ammonia ligase (EC 6.3.1.2).</obo:IAO_0000115>
+        <obo:IAO_0000115>An EC 6.3.* (&lt;em&gt;C&lt;/em&gt;‒&lt;em&gt;N&lt;/em&gt; bond-forming ligase) inhibitor that interferes with the action of glutamate—ammonia ligase (EC 6.3.1.2).</obo:IAO_0000115>
         <rdfs:label>EC 6.3.1.2 (glutamate--ammonia ligase) inhibitor</rdfs:label>
     </owl:Class>
     
@@ -5607,7 +5812,8 @@ For example, A and B may be gene products and binding of B by A positively regul
     <!-- http://purl.obolibrary.org/obo/CHEBI_24636 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_24636">
-        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_36342"/>
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_15378"/>
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33253"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/COB_0000013"/>
         <obo:IAO_0000115>Nuclear particle of charge number +1, spin 1/2 and rest mass of 1.007276470(12) u.</obo:IAO_0000115>
         <obo:IAO_0000115>Nuclear particle of charge number +1, spin ½ and rest mass of 1.007276470(12) u.</obo:IAO_0000115>
@@ -5629,6 +5835,7 @@ For example, A and B may be gene products and binding of B by A positively regul
             </owl:Restriction>
         </rdfs:subClassOf>
         <obo:IAO_0000115>Hydroxides are chemical compounds containing a hydroxy group or salts containing hydroxide (OH(-)).</obo:IAO_0000115>
+        <obo:IAO_0000115>Hydroxides are chemical compounds containing a hydroxy group or salts containing hydroxide (OH&lt;small&gt;&lt;sup&gt;−&lt;/small&gt;&lt;/sup&gt;).</obo:IAO_0000115>
         <rdfs:label>hydroxides</rdfs:label>
     </owl:Class>
     
@@ -5641,11 +5848,11 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_36248"/>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#has_functional_parent"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018038"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_36238"/>
             </owl:Restriction>
         </rdfs:subClassOf>
-        <obo:IAO_0000115>Any member of the class of 5beta-cholanic acids carrying at least one hydroxy group at unspecified position.</obo:IAO_0000115>
+        <obo:IAO_0000115>Any member of the class of 5β-cholanic acids carrying at least one hydroxy group at unspecified position.</obo:IAO_0000115>
         <rdfs:label>hydroxy-5beta-cholanic acid</rdfs:label>
     </owl:Class>
     
@@ -5717,12 +5924,6 @@ For example, A and B may be gene products and binding of B by A positively regul
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_22563"/>
             </owl:Restriction>
         </rdfs:subClassOf>
-        <rdfs:subClassOf>
-            <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
-                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_36916"/>
-            </owl:Restriction>
-        </rdfs:subClassOf>
         <obo:IAO_0000115>A salt is an assembly of cations and anions.</obo:IAO_0000115>
         <rdfs:label>salt</rdfs:label>
     </owl:Class>
@@ -5819,6 +6020,7 @@ For example, A and B may be gene products and binding of B by A positively regul
             </owl:Restriction>
         </rdfs:subClassOf>
         <obo:IAO_0000115>A group of neurotransmitters and neuromodulators that contain one amino group that is connected to an aromatic ring by ethylene group  (-CH2-CH2-). Monoamines are derived from the aromatic amino acids phenylalanine, tyrosine, histidine and tryptophan.</obo:IAO_0000115>
+        <obo:IAO_0000115>A group of neurotransmitters and neuromodulators that contain one amino group that is connected to an aromatic ring by ethylene group  (‒CH&lt;small&gt;&lt;sub&gt;2&lt;/sub&gt;&lt;/small&gt;‒CH&lt;small&gt;&lt;sub&gt;2&lt;/sub&gt;&lt;/small&gt;‒). Monoamines are derived from the aromatic amino acids phenylalanine, tyrosine, histidine and tryptophan.</obo:IAO_0000115>
         <rdfs:label>monoamine molecular messenger</rdfs:label>
     </owl:Class>
     
@@ -5828,6 +6030,12 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_25384">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33575"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35757"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
@@ -5920,6 +6128,12 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_25704">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_26820"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_58958"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
@@ -5996,7 +6210,7 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33709"/>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_tautomer_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018036"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_62031"/>
             </owl:Restriction>
         </rdfs:subClassOf>
@@ -6022,11 +6236,11 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35366"/>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_58951"/>
             </owl:Restriction>
         </rdfs:subClassOf>
-        <obo:IAO_0000115>An aliphatic monocarboxylic acid with a chain length of less than C6. If any non-hydrocarbon substituent is present, the compound is not normally regarded as a short-chain fatty acid.</obo:IAO_0000115>
+        <obo:IAO_0000115>An aliphatic monocarboxylic acid with a chain length of less than C&lt;small&gt;&lt;sub&gt;6&lt;/sub&gt;&lt;/small&gt;. If any non-hydrocarbon substituent is present, the compound is not normally regarded as a short-chain fatty acid.</obo:IAO_0000115>
         <rdfs:label>short-chain fatty acid</rdfs:label>
     </owl:Class>
     
@@ -6163,6 +6377,12 @@ For example, A and B may be gene products and binding of B by A positively regul
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35223"/>
             </owl:Restriction>
         </rdfs:subClassOf>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_45696"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
@@ -6268,7 +6488,7 @@ For example, A and B may be gene products and binding of B by A positively regul
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_76971"/>
             </owl:Restriction>
         </rdfs:subClassOf>
-        <obo:IAO_0000115>A polydisperse, highly branched glucan composed of chains of D-glucopyranose residues in alpha(1-&gt;4) glycosidic linkage, joined together by alpha(1-&gt;6) glycosidic linkages. A small number of alpha(1-&gt;3) glycosidic linkages and some cumulative alpha(1-&gt;6) links also may occur. The branches in glycogen typically contain 8 to 12 glucose residues.</obo:IAO_0000115>
+        <obo:IAO_0000115>A polydisperse, highly branched glucan composed of chains of &lt;small&gt;D&lt;/small&gt;-glucopyranose residues in α(1→4) glycosidic linkage, joined together by α(1→6) glycosidic linkages. A small number of α(1→3) glycosidic linkages and some cumulative α(1→6) links also may occur. The branches in glycogen typically contain 8 to 12 glucose residues.</obo:IAO_0000115>
         <rdfs:label>glycogen</rdfs:label>
     </owl:Class>
     
@@ -6286,6 +6506,12 @@ For example, A and B may be gene products and binding of B by A positively regul
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_76971"/>
             </owl:Restriction>
         </rdfs:subClassOf>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_13941"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
@@ -6324,6 +6550,18 @@ For example, A and B may be gene products and binding of B by A positively regul
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_77746"/>
             </owl:Restriction>
         </rdfs:subClassOf>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_350546"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018038"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_16765"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#has_functional_parent"/>
@@ -6349,7 +6587,7 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35757"/>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35366"/>
             </owl:Restriction>
         </rdfs:subClassOf>
@@ -6389,6 +6627,12 @@ For example, A and B may be gene products and binding of B by A positively regul
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_77746"/>
             </owl:Restriction>
         </rdfs:subClassOf>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_16134"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
@@ -6425,7 +6669,7 @@ For example, A and B may be gene products and binding of B by A positively regul
         </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_17544"/>
             </owl:Restriction>
         </rdfs:subClassOf>
@@ -6439,6 +6683,12 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_29067">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_25696"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35406"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33575"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of"/>
@@ -6481,6 +6731,18 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_29337">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35106"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_79389"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_16134"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_29340"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
@@ -6503,6 +6765,12 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_29340">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35106"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_79388"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_29337"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of"/>
@@ -6519,6 +6787,12 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_29793">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33693"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_15379"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
@@ -6554,23 +6828,23 @@ For example, A and B may be gene products and binding of B by A positively regul
         </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
-                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_29988"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_16015"/>
             </owl:Restriction>
         </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of"/>
-                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_16015"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_29988"/>
             </owl:Restriction>
         </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_enantiomer_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018039"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_29986"/>
             </owl:Restriction>
         </rdfs:subClassOf>
-        <obo:IAO_0000115>An alpha-amino-acid anion that is the conjugate base of L-glutamic acid, having anionic carboxy groups and a cationic amino group</obo:IAO_0000115>
+        <obo:IAO_0000115>An α-amino-acid anion that is the conjugate base of &lt;small&gt;L&lt;/small&gt;-glutamic acid, having anionic carboxy groups and a cationic amino group</obo:IAO_0000115>
         <rdfs:label>L-glutamate(1-)</rdfs:label>
     </owl:Class>
     
@@ -6582,23 +6856,23 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_14321"/>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
-                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_29989"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_15966"/>
             </owl:Restriction>
         </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of"/>
-                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_15966"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_29989"/>
             </owl:Restriction>
         </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_enantiomer_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018039"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_29985"/>
             </owl:Restriction>
         </rdfs:subClassOf>
-        <obo:IAO_0000115>An alpha-amino-acid anion that is the conjugate base of D-glutamic acid, having anionic carboxy groups and a cationic amino group</obo:IAO_0000115>
+        <obo:IAO_0000115>An α-amino-acid anion that is the conjugate base of &lt;small&gt;D&lt;/small&gt;-glutamic acid, having anionic carboxy groups and a cationic amino group</obo:IAO_0000115>
         <rdfs:label>D-glutamate(1-)</rdfs:label>
     </owl:Class>
     
@@ -6616,11 +6890,11 @@ For example, A and B may be gene products and binding of B by A positively regul
         </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_14321"/>
             </owl:Restriction>
         </rdfs:subClassOf>
-        <obo:IAO_0000115>A dicarboxylic acid dianion that is the conjugate base of glutamate(1-).</obo:IAO_0000115>
+        <obo:IAO_0000115>A dicarboxylic acid dianion that is the conjugate base of glutamate(1−).</obo:IAO_0000115>
         <rdfs:label>glutamate(2-)</rdfs:label>
     </owl:Class>
     
@@ -6633,17 +6907,17 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_59814"/>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_29985"/>
             </owl:Restriction>
         </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_enantiomer_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018039"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_29989"/>
             </owl:Restriction>
         </rdfs:subClassOf>
-        <obo:IAO_0000115>An L-alpha-amino acid anion that is the dianion obtained by the deprotonation of the both the carboxy groups of L-glutamic acid.</obo:IAO_0000115>
+        <obo:IAO_0000115>An &lt;small&gt;L&lt;/small&gt;-α-amino acid anion that is the dianion obtained by the deprotonation of the both the carboxy groups of &lt;small&gt;L&lt;/small&gt;-glutamic acid.</obo:IAO_0000115>
         <rdfs:label>L-glutamate(2-)</rdfs:label>
     </owl:Class>
     
@@ -6655,13 +6929,13 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_29987"/>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_29986"/>
             </owl:Restriction>
         </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_enantiomer_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018039"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_29988"/>
             </owl:Restriction>
         </rdfs:subClassOf>
@@ -6686,6 +6960,12 @@ For example, A and B may be gene products and binding of B by A positively regul
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_77746"/>
             </owl:Restriction>
         </rdfs:subClassOf>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_15366"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of"/>
@@ -6702,6 +6982,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_30212">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_36341"/>
+        <obo:IAO_0000115>Particle of zero charge, zero rest mass, spin quantum number 1, energy &lt;em&gt;h&lt;/em&gt;&lt;em&gt;ν&lt;/em&gt; and momentum &lt;em&gt;h&lt;/em&gt;&lt;em&gt;ν&lt;/em&gt;/&lt;em&gt;c&lt;/em&gt; (&lt;em&gt;h&lt;/em&gt; is the Planck constant, &lt;em&gt;ν&lt;/em&gt; the frequency of radiation and &lt;em&gt;c&lt;/em&gt; the speed of light), carrier of electromagnetic force.</obo:IAO_0000115>
         <obo:IAO_0000115>Particle of zero charge, zero rest mass, spin quantum number 1, energy hnu and momentum hnu/c (h is the Planck constant, nu the frequency of radiation and c the speed of light), carrier of electromagnetic force.</obo:IAO_0000115>
         <rdfs:label>photon</rdfs:label>
     </owl:Class>
@@ -6720,17 +7001,17 @@ For example, A and B may be gene products and binding of B by A positively regul
         </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#has_functional_parent"/>
-                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_17968"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_16865"/>
             </owl:Restriction>
         </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of"/>
-                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_16865"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018038"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_17968"/>
             </owl:Restriction>
         </rdfs:subClassOf>
-        <obo:IAO_0000115>An gamma-amino acid anion resulting from the deprotonation of the carboxy group of gamma-aminobutyric acid.</obo:IAO_0000115>
+        <obo:IAO_0000115>An γ-amino acid anion resulting from the deprotonation of the carboxy group of γ-aminobutyric acid.</obo:IAO_0000115>
         <rdfs:label>gamma-aminobutyrate</rdfs:label>
     </owl:Class>
     
@@ -6755,7 +7036,7 @@ For example, A and B may be gene products and binding of B by A positively regul
         </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_17968"/>
             </owl:Restriction>
         </rdfs:subClassOf>
@@ -6770,7 +7051,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_3098">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_138366"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_24663"/>
-        <obo:IAO_0000115>Any member of a group of hydroxy-5beta-cholanic acids occuring in bile, where they are present as the sodium salts of their amides with glycine or taurine. In mammals bile acids almost invariably have 5beta-configuration.</obo:IAO_0000115>
+        <obo:IAO_0000115>Any member of a group of hydroxy-5β-cholanic acids occuring in bile, where they are present as the sodium salts of their amides with glycine or taurine. In mammals bile acids almost invariably have 5β-configuration.</obo:IAO_0000115>
         <rdfs:label>bile acid</rdfs:label>
     </owl:Class>
     
@@ -6790,6 +7071,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_32988">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_51143"/>
+        <obo:IAO_0000115>An amide is a derivative of an oxoacid R&lt;small&gt;&lt;sub&gt;&lt;em&gt;k&lt;/em&gt;&lt;/sub&gt;&lt;/small&gt;E(=O)&lt;small&gt;&lt;sub&gt;&lt;em&gt;l&lt;/em&gt;&lt;/sub&gt;&lt;/small&gt;(OH)&lt;small&gt;&lt;sub&gt;&lt;em&gt;m&lt;/em&gt;&lt;/sub&gt;&lt;/small&gt; (&lt;em&gt;l&lt;/em&gt; ≠ 0) in which an acidic hydroxy group has been replaced by an amino or substituted amino group.</obo:IAO_0000115>
         <obo:IAO_0000115>An amide is a derivative of an oxoacid RkE(=O)l(OH)m (l =/= 0) in which an acidic hydroxy group has been replaced by an amino or substituted amino group.</obo:IAO_0000115>
         <rdfs:label>amide</rdfs:label>
     </owl:Class>
@@ -6830,6 +7112,12 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_33241">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_37577"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018038"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_24833"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#has_functional_parent"/>
@@ -6876,6 +7164,18 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_33247">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_24433"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_64769"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_64775"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
@@ -6908,12 +7208,6 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_33250">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_24431"/>
-        <rdfs:subClassOf>
-            <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
-                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_10545"/>
-            </owl:Restriction>
-        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
@@ -6926,6 +7220,16 @@ For example, A and B may be gene products and binding of B by A positively regul
     
 
 
+    <!-- http://purl.obolibrary.org/obo/CHEBI_33251 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_33251">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33238"/>
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33260"/>
+        <rdfs:label>monoatomic hydrogen</rdfs:label>
+    </owl:Class>
+    
+
+
     <!-- http://purl.obolibrary.org/obo/CHEBI_33252 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_33252">
@@ -6957,6 +7261,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_33256">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_32988"/>
+        <obo:IAO_0000115>A derivative of an oxoacid R&lt;small&gt;&lt;sub&gt;&lt;em&gt;k&lt;/em&gt;&lt;/sub&gt;&lt;/small&gt;E(=O)&lt;small&gt;&lt;sub&gt;&lt;em&gt;l&lt;/em&gt;&lt;/sub&gt;&lt;/small&gt;(OH)&lt;small&gt;&lt;sub&gt;&lt;em&gt;m&lt;/em&gt;&lt;/sub&gt;&lt;/small&gt; (&lt;em&gt;l&lt;/em&gt; ≠ 0) in which an acidic hydroxy group has been replaced by an amino or substituted amino group.</obo:IAO_0000115>
         <obo:IAO_0000115>A derivative of an oxoacid RkE(=O)l(OH)m (l =/= 0) in which an acidic hydroxy group has been replaced by an amino or substituted amino group.</obo:IAO_0000115>
         <rdfs:label>primary amide</rdfs:label>
     </owl:Class>
@@ -6973,6 +7278,17 @@ For example, A and B may be gene products and binding of B by A positively regul
     
 
 
+    <!-- http://purl.obolibrary.org/obo/CHEBI_33260 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_33260">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_24835"/>
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33259"/>
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33608"/>
+        <rdfs:label>elemental hydrogen</rdfs:label>
+    </owl:Class>
+    
+
+
     <!-- http://purl.obolibrary.org/obo/CHEBI_33262 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_33262">
@@ -7126,6 +7442,7 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35701"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_36586"/>
         <obo:IAO_0000115>An ester of a carboxylic acid, R(1)C(=O)OR(2), where R(1) = H or organyl and R(2) = organyl.</obo:IAO_0000115>
+        <obo:IAO_0000115>An ester of a carboxylic acid, R&lt;small&gt;&lt;sup&gt;1&lt;/small&gt;&lt;/sup&gt;C(=O)OR&lt;small&gt;&lt;sup&gt;2&lt;/small&gt;&lt;/sup&gt;, where R&lt;small&gt;&lt;sup&gt;1&lt;/small&gt;&lt;/sup&gt; = H or organyl and R&lt;small&gt;&lt;sup&gt;2&lt;/small&gt;&lt;/sup&gt; = organyl.</obo:IAO_0000115>
         <rdfs:label>carboxylic ester</rdfs:label>
     </owl:Class>
     
@@ -7218,6 +7535,12 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_33558">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_37022"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33704"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of"/>
@@ -7225,6 +7548,7 @@ For example, A and B may be gene products and binding of B by A positively regul
             </owl:Restriction>
         </rdfs:subClassOf>
         <obo:IAO_0000115>An amino-acid anion obtained by deprotonation of any alpha-amino acid.</obo:IAO_0000115>
+        <obo:IAO_0000115>An amino-acid anion obtained by deprotonation of any α-amino acid.</obo:IAO_0000115>
         <rdfs:label>alpha-amino-acid anion</rdfs:label>
     </owl:Class>
     
@@ -7253,7 +7577,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_33566">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33570"/>
-        <obo:IAO_0000115>Any compound containing an o-diphenol component.</obo:IAO_0000115>
+        <obo:IAO_0000115>Any compound containing an &lt;em&gt;o&lt;/em&gt;-diphenol component.</obo:IAO_0000115>
         <rdfs:label>catechols</rdfs:label>
     </owl:Class>
     
@@ -7282,7 +7606,7 @@ For example, A and B may be gene products and binding of B by A positively regul
         </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_166902"/>
             </owl:Restriction>
         </rdfs:subClassOf>
@@ -7307,11 +7631,17 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33569"/>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_enantiomer_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_234420"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018039"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_18357"/>
             </owl:Restriction>
         </rdfs:subClassOf>
-        <obo:IAO_0000115>The S-enantiomer of noradrenaline.</obo:IAO_0000115>
+        <obo:IAO_0000115>The &lt;i&gt;S&lt;/i&gt;-enantiomer of noradrenaline.</obo:IAO_0000115>
         <rdfs:label>(S)-noradrenaline</rdfs:label>
     </owl:Class>
     
@@ -7329,6 +7659,12 @@ For example, A and B may be gene products and binding of B by A positively regul
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_46883"/>
             </owl:Restriction>
         </rdfs:subClassOf>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_29067"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
@@ -7336,6 +7672,7 @@ For example, A and B may be gene products and binding of B by A positively regul
             </owl:Restriction>
         </rdfs:subClassOf>
         <obo:IAO_0000115>A carbon oxoacid acid carrying at least one -C(=O)OH group and having the structure RC(=O)OH, where R is any any monovalent functional group. Carboxylic acids are the most common type of organic acid.</obo:IAO_0000115>
+        <obo:IAO_0000115>A carbon oxoacid acid carrying at least one ‒C(=O)OH group and having the structure RC(=O)OH, where R is any any monovalent functional group. Carboxylic acids are the most common type of organic acid.</obo:IAO_0000115>
         <rdfs:label>carboxylic acid</rdfs:label>
     </owl:Class>
     
@@ -7386,12 +7723,6 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_33608">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33674"/>
-        <rdfs:subClassOf>
-            <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
-                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_49637"/>
-            </owl:Restriction>
-        </rdfs:subClassOf>
         <rdfs:label>hydrogen molecular entity</rdfs:label>
     </owl:Class>
     
@@ -7421,6 +7752,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_33655">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33595"/>
         <obo:IAO_0000115>A cyclically conjugated molecular entity with a stability (due to delocalization) significantly greater than that of a hypothetical localized structure (e.g. Kekule structure) is said to possess aromatic character.</obo:IAO_0000115>
+        <obo:IAO_0000115>A cyclically conjugated molecular entity with a stability (due to delocalization) significantly greater than that of a hypothetical localized structure (e.g. Kekulé structure) is said to possess aromatic character.</obo:IAO_0000115>
         <rdfs:label>aromatic compound</rdfs:label>
     </owl:Class>
     
@@ -7462,12 +7794,6 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_33674">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33579"/>
-        <rdfs:subClassOf>
-            <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
-                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33559"/>
-            </owl:Restriction>
-        </rdfs:subClassOf>
         <obo:IAO_0000115>An s-block molecular entity is a molecular entity containing one or more atoms of an s-block element.</obo:IAO_0000115>
         <rdfs:label>s-block molecular entity</rdfs:label>
     </owl:Class>
@@ -7546,6 +7872,7 @@ For example, A and B may be gene products and binding of B by A positively regul
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_50297"/>
             </owl:Restriction>
         </rdfs:subClassOf>
+        <obo:IAO_0000115>A macromolecule made up of nucleotide units and hydrolysable into certain pyrimidine or purine bases (usually adenine, cytosine, guanine, thymine, uracil), &lt;small&gt;D&lt;/small&gt;-ribose or 2-deoxy-&lt;small&gt;D&lt;/small&gt;-ribose and phosphoric acid.</obo:IAO_0000115>
         <obo:IAO_0000115>A macromolecule made up of nucleotide units and hydrolysable into certain pyrimidine or purine bases (usually adenine, cytosine, guanine, thymine, uracil), D-ribose or 2-deoxy-D-ribose and phosphoric acid.</obo:IAO_0000115>
         <rdfs:label>nucleic acid</rdfs:label>
     </owl:Class>
@@ -7599,6 +7926,12 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_33703">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_25697"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33702"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33709"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
@@ -7614,6 +7947,24 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_33704">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33709"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33719"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33558"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018036"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_78608"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
@@ -7633,6 +7984,7 @@ For example, A and B may be gene products and binding of B by A positively regul
             </owl:Restriction>
         </rdfs:subClassOf>
         <obo:IAO_0000115>An amino acid in which the amino group is located on the carbon atom at the position alpha to the carboxy group.</obo:IAO_0000115>
+        <obo:IAO_0000115>An amino acid in which the amino group is located on the carbon atom at the position α to the carboxy group.</obo:IAO_0000115>
         <rdfs:label>alpha-amino acid</rdfs:label>
     </owl:Class>
     
@@ -7644,11 +7996,11 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_83820"/>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_71666"/>
             </owl:Restriction>
         </rdfs:subClassOf>
-        <obo:IAO_0000115>A non-proteinogenic amino-acid in which the amino group is located on the carbon atom at the position gamma to the carboxy group.</obo:IAO_0000115>
+        <obo:IAO_0000115>A non-proteinogenic amino-acid in which the amino group is located on the carbon atom at the position γ to the carboxy group.</obo:IAO_0000115>
         <rdfs:label>gamma-amino acid</rdfs:label>
     </owl:Class>
     
@@ -7658,6 +8010,24 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_33708">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33247"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_58942"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_64898"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018037"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33709"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
@@ -7687,6 +8057,18 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_33709">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33575"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_50047"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33703"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_37022"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
@@ -7709,6 +8091,12 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_33710">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33708"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018037"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33704"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_substituent_group_from"/>
@@ -7716,6 +8104,7 @@ For example, A and B may be gene products and binding of B by A positively regul
             </owl:Restriction>
         </rdfs:subClassOf>
         <obo:IAO_0000115>An amino-acid residue derived from an alpha-amino acid.</obo:IAO_0000115>
+        <obo:IAO_0000115>An amino-acid residue derived from an α-amino acid.</obo:IAO_0000115>
         <rdfs:label>alpha-amino-acid residue</rdfs:label>
     </owl:Class>
     
@@ -7725,6 +8114,12 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_33719">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33703"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33704"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
@@ -7741,6 +8136,12 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_33720">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_16646"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33575"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33721"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
@@ -7756,6 +8157,12 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_33721">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_29067"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33720"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of"/>
@@ -7813,6 +8220,7 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_24532"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33659"/>
         <obo:IAO_0000115>A heterocyclic compound formally derived from an arene by replacement of one or more methine (-C=) and/or vinylene (-CH=CH-) groups by trivalent or divalent heteroatoms, respectively, in such a way as to maintain the continuous pi-electron system characteristic of aromatic systems and a number of out-of-plane pi-electrons corresponding to the Hueckel rule (4n+2).</obo:IAO_0000115>
+        <obo:IAO_0000115>A heterocyclic compound formally derived from an arene by replacement of one or more methine (‒C=) and/or vinylene (‒CH=CH‒) groups by trivalent or divalent heteroatoms, respectively, in such a way as to maintain the continuous π-electron system characteristic of aromatic systems and a number of out-of-plane π-electrons corresponding to the Hückel rule (4&lt;em&gt;n&lt;/em&gt;+2).</obo:IAO_0000115>
         <rdfs:label>heteroarene</rdfs:label>
     </owl:Class>
     
@@ -7893,6 +8301,12 @@ For example, A and B may be gene products and binding of B by A positively regul
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_77746"/>
             </owl:Restriction>
         </rdfs:subClassOf>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_28790"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
@@ -7919,6 +8333,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_35107">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35106"/>
+        <obo:IAO_0000115>Saturated acyclic nitrogen hydrides having the general formula N&lt;small&gt;&lt;sub&gt;&lt;em&gt;n&lt;/em&gt;&lt;/sub&gt;&lt;/small&gt;H&lt;small&gt;&lt;sub&gt;&lt;em&gt;n&lt;/em&gt;+2&lt;/sub&gt;&lt;/small&gt;.</obo:IAO_0000115>
         <obo:IAO_0000115>Saturated acyclic nitrogen hydrides having the general formula NnHn+2.</obo:IAO_0000115>
         <rdfs:label>azane</rdfs:label>
     </owl:Class>
@@ -7961,6 +8376,7 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_25697"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35274"/>
         <obo:IAO_0000115>A derivative of ammonium, NH4(+), in which all four of the hydrogens bonded to nitrogen have been replaced with univalent (usually organyl) groups.</obo:IAO_0000115>
+        <obo:IAO_0000115>A derivative of ammonium, NH&lt;small&gt;&lt;sub&gt;4&lt;/sub&gt;&lt;/small&gt;&lt;small&gt;&lt;sup&gt;+&lt;/small&gt;&lt;/sup&gt;, in which all four of the hydrogens bonded to nitrogen have been replaced with univalent (usually organyl) groups.</obo:IAO_0000115>
         <rdfs:label>quaternary ammonium ion</rdfs:label>
     </owl:Class>
     
@@ -7971,6 +8387,12 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_35274">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33702"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_51143"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018040"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_28938"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#has_parent_hydride"/>
@@ -7978,6 +8400,7 @@ For example, A and B may be gene products and binding of B by A positively regul
             </owl:Restriction>
         </rdfs:subClassOf>
         <obo:IAO_0000115>A derivative of ammonium, NH4(+), in which one (or more) of the hydrogens bonded to the nitrogen have been replaced with univalent organyl groups. The substituting carbon of the organyl group must not itself be directly attached to a heteroatom (thereby excluding protonated amides, hemiaminals, etc).</obo:IAO_0000115>
+        <obo:IAO_0000115>A derivative of ammonium, NH&lt;small&gt;&lt;sub&gt;4&lt;/sub&gt;&lt;/small&gt;&lt;small&gt;&lt;sup&gt;+&lt;/small&gt;&lt;/sup&gt;, in which one (or more) of the hydrogens bonded to the nitrogen have been replaced with univalent organyl groups. The substituting carbon of the organyl group must not itself be directly attached to a heteroatom (thereby excluding protonated amides, hemiaminals, etc).</obo:IAO_0000115>
         <rdfs:label>ammonium ion derivative</rdfs:label>
     </owl:Class>
     
@@ -7998,6 +8421,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_35341">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_18059"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_51958"/>
+        <obo:IAO_0000115>Any of naturally occurring compounds and synthetic analogues, based on the cyclopenta[&lt;em&gt;a&lt;/em&gt;]phenanthrene carbon skeleton, partially or completely hydrogenated; there are usually methyl groups at C-10 and C-13, and often an alkyl group at C-17. By extension, one or more bond scissions, ring expansions and/or ring contractions of the skeleton may have occurred. Natural steroids are derived biogenetically from squalene which is a triterpene.</obo:IAO_0000115>
         <obo:IAO_0000115>Any of naturally occurring compounds and synthetic analogues, based on the cyclopenta[a]phenanthrene carbon skeleton, partially or completely hydrogenated; there are usually methyl groups at C-10 and C-13, and often an alkyl group at C-17. By extension, one or more bond scissions, ring expansions and/or ring contractions of the skeleton may have occurred. Natural steroids are derived biogenetically from squalene which is a triterpene.</obo:IAO_0000115>
         <rdfs:label>steroid</rdfs:label>
     </owl:Class>
@@ -8032,7 +8456,7 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_25384"/>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_28868"/>
             </owl:Restriction>
         </rdfs:subClassOf>
@@ -8046,7 +8470,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_35381">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_16646"/>
-        <obo:IAO_0000115>Parent monosaccharides are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H-[CHOH]n-C(=O)[CHOH]m-H with three or more carbon atoms. The generic term &apos;monosaccharide&apos; (as opposed to oligosaccharide or polysaccharide) denotes a single unit, without glycosidic connection to other such units. It includes aldoses, dialdoses, aldoketoses, ketoses and diketoses, as well as deoxy sugars, provided that the parent compound has a (potential) carbonyl group.</obo:IAO_0000115>
+        <obo:IAO_0000115>Parent monosaccharides are polyhydroxy aldehydes H[CH(OH)]&lt;small&gt;&lt;sub&gt;&lt;em&gt;n&lt;/em&gt;&lt;/sub&gt;&lt;/small&gt;C(=O)H or polyhydroxy ketones H‒[CHOH]&lt;small&gt;&lt;sub&gt;&lt;em&gt;n&lt;/em&gt;&lt;/sub&gt;&lt;/small&gt;‒C(=O)[CHOH]&lt;small&gt;&lt;sub&gt;&lt;em&gt;m&lt;/em&gt;&lt;/sub&gt;&lt;/small&gt;‒H with three or more carbon atoms. The generic term &apos;monosaccharide&apos; (as opposed to oligosaccharide or polysaccharide) denotes a single unit, without glycosidic connection to other such units. It includes aldoses, dialdoses, aldoketoses, ketoses and diketoses, as well as deoxy sugars, provided that the parent compound has a (potential) carbonyl group.</obo:IAO_0000115>
         <rdfs:label>monosaccharide</rdfs:label>
     </owl:Class>
     
@@ -8137,7 +8561,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_35569">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_37886"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_48539"/>
-        <obo:IAO_0000115>An agent that selectively binds to and activates alpha-adrenergic receptors.</obo:IAO_0000115>
+        <obo:IAO_0000115>An agent that selectively binds to and activates α-adrenergic receptors.</obo:IAO_0000115>
         <rdfs:label>alpha-adrenergic agonist</rdfs:label>
     </owl:Class>
     
@@ -8149,7 +8573,7 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_25696"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35406"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_36963"/>
-        <obo:IAO_0000115>A negative ion consisting solely of carbon and oxygen  atoms, and therefore having the general formula CxOy(n-) for some integers x, y and n.</obo:IAO_0000115>
+        <obo:IAO_0000115>A negative ion consisting solely of carbon and oxygen  atoms, and therefore having the general formula C&lt;small&gt;&lt;sub&gt;&lt;em&gt;x&lt;/em&gt;&lt;/sub&gt;&lt;/small&gt;O&lt;small&gt;&lt;sub&gt;&lt;em&gt;y&lt;/em&gt;&lt;/sub&gt;&lt;/small&gt;&lt;small&gt;&lt;sup&gt;&lt;em&gt;n&lt;/em&gt;−&lt;/small&gt;&lt;/sup&gt; for some integers &lt;em&gt;x&lt;/em&gt;, &lt;em&gt;y&lt;/em&gt; and &lt;em&gt;n&lt;/em&gt;.</obo:IAO_0000115>
         <rdfs:label>carbon oxoanion</rdfs:label>
     </owl:Class>
     
@@ -8182,7 +8606,7 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33575"/>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35693"/>
             </owl:Restriction>
         </rdfs:subClassOf>
@@ -8198,7 +8622,7 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_29067"/>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35692"/>
             </owl:Restriction>
         </rdfs:subClassOf>
@@ -8211,6 +8635,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_35701">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_36963"/>
+        <obo:IAO_0000115>A compound formally derived from an oxoacid R&lt;small&gt;&lt;sub&gt;&lt;em&gt;k&lt;/em&gt;&lt;/sub&gt;&lt;/small&gt;E(=O)&lt;small&gt;&lt;sub&gt;&lt;em&gt;l&lt;/em&gt;&lt;/sub&gt;&lt;/small&gt;(OH)&lt;small&gt;&lt;sub&gt;&lt;em&gt;m&lt;/em&gt;&lt;/sub&gt;&lt;/small&gt; (&lt;em&gt;l&lt;/em&gt; &gt; 0) and an alcohol, phenol, heteroarenol, or enol by linking with formal loss of water from an acidic hydroxy group of the former and a hydroxy group of the latter.</obo:IAO_0000115>
         <obo:IAO_0000115>A compound formally derived from an oxoacid RkE(=O)l(OH)m (l &gt; 0) and an alcohol, phenol, heteroarenol, or enol by linking with formal loss of water from an acidic hydroxy group of the former and a hydroxy group of the latter.</obo:IAO_0000115>
         <rdfs:label>ester</rdfs:label>
     </owl:Class>
@@ -8242,6 +8667,12 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_35757">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_29067"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_25384"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of"/>
@@ -8281,7 +8712,7 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35341"/>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#has_parent_hydride"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018040"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35519"/>
             </owl:Restriction>
         </rdfs:subClassOf>
@@ -8347,11 +8778,11 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_36278"/>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#has_parent_hydride"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018040"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_20664"/>
             </owl:Restriction>
         </rdfs:subClassOf>
-        <obo:IAO_0000115>Members of the class of cholanic acids based on a 5beta-cholane skeleton.</obo:IAO_0000115>
+        <obo:IAO_0000115>Members of the class of cholanic acids based on a 5β-cholane skeleton.</obo:IAO_0000115>
         <rdfs:label>5beta-cholanic acids</rdfs:label>
     </owl:Class>
     
@@ -8384,6 +8815,7 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33233"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_36340"/>
         <obo:IAO_0000115>Lepton is a fermion that does not experience the strong force (strong interaction). The term is derived from the Greek lambdaepsilonpitauomicronsigma (small, thin).</obo:IAO_0000115>
+        <obo:IAO_0000115>Lepton is a fermion that does not experience the strong force (strong interaction). The term is derived from the Greek λεπτοσ (small, thin).</obo:IAO_0000115>
         <rdfs:label>lepton</rdfs:label>
     </owl:Class>
     
@@ -8395,6 +8827,7 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_36340"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_36344"/>
         <obo:IAO_0000115>Baryon is a fermion that does experience the strong force (strong interaction). The term is derived from the Greek betaalpharhoupsilonsigma (heavy).</obo:IAO_0000115>
+        <obo:IAO_0000115>Baryon is a fermion that does experience the strong force (strong interaction). The term is derived from the Greek βαρυσ (heavy).</obo:IAO_0000115>
         <rdfs:label>baryon</rdfs:label>
     </owl:Class>
     
@@ -8607,6 +9040,12 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_37022">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_29067"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35352"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33709"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of"/>
@@ -8680,6 +9119,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_37527">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_51086"/>
         <obo:IAO_0000115>An acid is a molecular entity capable of donating a hydron (Bronsted acid) or capable of forming a covalent bond with an electron pair (Lewis acid).</obo:IAO_0000115>
+        <obo:IAO_0000115>An acid is a molecular entity capable of donating a hydron (Brønsted acid) or capable of forming a covalent bond with an electron pair (Lewis acid).</obo:IAO_0000115>
         <rdfs:label>acid</rdfs:label>
     </owl:Class>
     
@@ -8708,6 +9148,7 @@ For example, A and B may be gene products and binding of B by A positively regul
             </owl:Restriction>
         </rdfs:subClassOf>
         <obo:IAO_0000115>An amide of a carboxylic acid, having the structure RC(=O)NR2. The term is used as a suffix in systematic name formation to denote the -C(=O)NH2 group including its carbon atom.</obo:IAO_0000115>
+        <obo:IAO_0000115>An amide of a carboxylic acid, having the structure RC(=O)NR&lt;small&gt;&lt;sub&gt;2&lt;/sub&gt;&lt;/small&gt;. The term is used as a suffix in systematic name formation to denote the ‒C(=O)NH&lt;small&gt;&lt;sub&gt;2&lt;/sub&gt;&lt;/small&gt; group including its carbon atom.</obo:IAO_0000115>
         <rdfs:label>carboxamide</rdfs:label>
     </owl:Class>
     
@@ -8726,6 +9167,12 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_37826">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33424"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018038"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_26836"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#has_functional_parent"/>
@@ -8741,6 +9188,12 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_37838">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_22221"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018037"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33575"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_substituent_group_from"/>
@@ -8894,6 +9347,7 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_17891"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_37527"/>
         <obo:IAO_0000115>A molecular entity capable of donating a hydron to an acceptor (Bronsted base).</obo:IAO_0000115>
+        <obo:IAO_0000115>A molecular entity capable of donating a hydron to an acceptor (Brønsted base).</obo:IAO_0000115>
         <rdfs:label>Bronsted acid</rdfs:label>
     </owl:Class>
     
@@ -8905,6 +9359,7 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_15339"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_22695"/>
         <obo:IAO_0000115>A molecular entity capable of accepting a hydron from a donor (Bronsted acid).</obo:IAO_0000115>
+        <obo:IAO_0000115>A molecular entity capable of accepting a hydron from a donor (Brønsted acid).</obo:IAO_0000115>
         <rdfs:label>Bronsted base</rdfs:label>
     </owl:Class>
     
@@ -8928,7 +9383,7 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_59202"/>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_58954"/>
             </owl:Restriction>
         </rdfs:subClassOf>
@@ -8944,7 +9399,7 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35604"/>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_17544"/>
             </owl:Restriction>
         </rdfs:subClassOf>
@@ -8982,7 +9437,7 @@ For example, A and B may be gene products and binding of B by A positively regul
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_77746"/>
             </owl:Restriction>
         </rdfs:subClassOf>
-        <obo:IAO_0000115>A glucopyranose having D-configuration.</obo:IAO_0000115>
+        <obo:IAO_0000115>A glucopyranose having &lt;small&gt;D&lt;/small&gt;-configuration.</obo:IAO_0000115>
         <rdfs:label>D-glucopyranose</rdfs:label>
     </owl:Class>
     
@@ -8992,7 +9447,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_4194">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_18133"/>
-        <obo:IAO_0000115>A hexose that has D-configuration at position 5.</obo:IAO_0000115>
+        <obo:IAO_0000115>A hexose that has &lt;small&gt;D&lt;/small&gt;-configuration at position 5.</obo:IAO_0000115>
         <rdfs:label>D-hexose</rdfs:label>
     </owl:Class>
     
@@ -9011,6 +9466,18 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_45696">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33482"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_26836"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_16189"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
@@ -9061,6 +9528,12 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_47622">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33308"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018038"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_15366"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#has_functional_parent"/>
@@ -9080,7 +9553,7 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_64709"/>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_50160"/>
             </owl:Restriction>
         </rdfs:subClassOf>
@@ -9125,7 +9598,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_48539">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_37962"/>
-        <obo:IAO_0000115>Any drug that acts on an alpha-adrenergic receptor.</obo:IAO_0000115>
+        <obo:IAO_0000115>Any drug that acts on an α-adrenergic receptor.</obo:IAO_0000115>
         <rdfs:label>alpha-adrenergic drug</rdfs:label>
     </owl:Class>
     
@@ -9168,6 +9641,12 @@ For example, A and B may be gene products and binding of B by A positively regul
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_39142"/>
             </owl:Restriction>
         </rdfs:subClassOf>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018040"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_16134"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#has_parent_hydride"/>
@@ -9186,7 +9665,7 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_29067"/>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_47891"/>
             </owl:Restriction>
         </rdfs:subClassOf>
@@ -9330,6 +9809,12 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_50994">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_50047"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_65296"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of"/>
@@ -9449,6 +9934,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_52211">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_24432"/>
+        <obo:IAO_0000115>A biological role relating to the normal mechanisms and their interactions within a living system.</obo:IAO_0000115>
         <rdfs:label>physiological role</rdfs:label>
     </owl:Class>
     
@@ -9546,6 +10032,12 @@ For example, A and B may be gene products and binding of B by A positively regul
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_77746"/>
             </owl:Restriction>
         </rdfs:subClassOf>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_16765"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
@@ -9571,7 +10063,7 @@ For example, A and B may be gene products and binding of B by A positively regul
         </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_16990"/>
             </owl:Restriction>
         </rdfs:subClassOf>
@@ -9585,6 +10077,12 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_58942">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_64769"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33708"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
@@ -9603,11 +10101,11 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_28868"/>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_26666"/>
             </owl:Restriction>
         </rdfs:subClassOf>
-        <obo:IAO_0000115>Any fatty acid anion obtained by removal of a proton from the carboxy group of a short-chain fatty acid (chain length of less than C6).</obo:IAO_0000115>
+        <obo:IAO_0000115>Any fatty acid anion obtained by removal of a proton from the carboxy group of a short-chain fatty acid (chain length of less than C&lt;small&gt;&lt;sub&gt;6&lt;/sub&gt;&lt;/small&gt;).</obo:IAO_0000115>
         <rdfs:label>short-chain fatty acid anion</rdfs:label>
     </owl:Class>
     
@@ -9617,7 +10115,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_58953">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_28868"/>
-        <obo:IAO_0000115>Any fatty acid anion in which there is no C-C unsaturation.</obo:IAO_0000115>
+        <obo:IAO_0000115>Any fatty acid anion in which there is no C‒C unsaturation.</obo:IAO_0000115>
         <rdfs:label>saturated fatty acid anion</rdfs:label>
     </owl:Class>
     
@@ -9629,7 +10127,7 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_58953"/>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_39418"/>
             </owl:Restriction>
         </rdfs:subClassOf>
@@ -9644,6 +10142,18 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_58958">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_25696"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33482"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_25704"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018038"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_16189"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#has_functional_parent"/>
@@ -9657,6 +10167,7 @@ For example, A and B may be gene products and binding of B by A positively regul
             </owl:Restriction>
         </rdfs:subClassOf>
         <obo:IAO_0000115>An organic anion of general formula RS(=O)2O(-) where R is an organyl group.</obo:IAO_0000115>
+        <obo:IAO_0000115>An organic anion of general formula RS(=O)2O(−) where R is an organyl group.</obo:IAO_0000115>
         <rdfs:label>organosulfate oxoanion</rdfs:label>
     </owl:Class>
     
@@ -9668,7 +10179,7 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35366"/>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_59203"/>
             </owl:Restriction>
         </rdfs:subClassOf>
@@ -9684,7 +10195,7 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_28868"/>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_59202"/>
             </owl:Restriction>
         </rdfs:subClassOf>
@@ -9721,11 +10232,11 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33558"/>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_15705"/>
             </owl:Restriction>
         </rdfs:subClassOf>
-        <obo:IAO_0000115>Conjugate base of an L-alpha-amino acid arising from deprotonation of the C-1 carboxy group.</obo:IAO_0000115>
+        <obo:IAO_0000115>Conjugate base of an &lt;small&gt;L&lt;/small&gt;-α-amino acid arising from deprotonation of the C-1 carboxy group.</obo:IAO_0000115>
         <rdfs:label>L-alpha-amino acid anion</rdfs:label>
     </owl:Class>
     
@@ -9737,11 +10248,11 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_78608"/>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_tautomer_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018036"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_15705"/>
             </owl:Restriction>
         </rdfs:subClassOf>
-        <obo:IAO_0000115>Zwitterionic form of an L-alpha-amino acid having an anionic carboxy group and a protonated amino group.</obo:IAO_0000115>
+        <obo:IAO_0000115>Zwitterionic form of an &lt;small&gt;L&lt;/small&gt;-α-amino acid having an anionic carboxy group and a protonated amino group.</obo:IAO_0000115>
         <rdfs:label>L-alpha-amino acid zwitterion</rdfs:label>
     </owl:Class>
     
@@ -9753,11 +10264,11 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35238"/>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_tautomer_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018036"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_16733"/>
             </owl:Restriction>
         </rdfs:subClassOf>
-        <obo:IAO_0000115>Zwitterionic form of a D-alpha-amino acid having an anionic carboxy group and a protonated amino group.</obo:IAO_0000115>
+        <obo:IAO_0000115>Zwitterionic form of a &lt;small&gt;D&lt;/small&gt;-α-amino acid having an anionic carboxy group and a protonated amino group.</obo:IAO_0000115>
         <rdfs:label>D-alpha-amino acid zwitterion</rdfs:label>
     </owl:Class>
     
@@ -9769,11 +10280,11 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35238"/>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_tautomer_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018036"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_16865"/>
             </owl:Restriction>
         </rdfs:subClassOf>
-        <obo:IAO_0000115>Zwitterionic form of gamma-aminobutyric acid having an anionic carboxy group and a protonated amino group.</obo:IAO_0000115>
+        <obo:IAO_0000115>Zwitterionic form of γ-aminobutyric acid having an anionic carboxy group and a protonated amino group.</obo:IAO_0000115>
         <rdfs:label>gamma-aminobutyric acid zwitterion</rdfs:label>
     </owl:Class>
     
@@ -9845,6 +10356,12 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_60466">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_27369"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018036"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_16670"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_tautomer_of"/>
@@ -9863,11 +10380,11 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33558"/>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_16733"/>
             </owl:Restriction>
         </rdfs:subClassOf>
-        <obo:IAO_0000115>Any alpha-amino acid anion in which the parent amino acid has D-configuration.</obo:IAO_0000115>
+        <obo:IAO_0000115>Any α-amino acid anion in which the parent amino acid has &lt;small&gt;D&lt;/small&gt;-configuration.</obo:IAO_0000115>
         <rdfs:label>D-alpha-amino acid anion</rdfs:label>
     </owl:Class>
     
@@ -9888,6 +10405,12 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_61120">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33833"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_51143"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018038"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_18282"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#has_functional_parent"/>
@@ -9922,7 +10445,7 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35238"/>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_tautomer_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018036"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_26167"/>
             </owl:Restriction>
         </rdfs:subClassOf>
@@ -9956,6 +10479,12 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_63299">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_78616"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018038"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_16646"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#has_functional_parent"/>
@@ -9972,6 +10501,18 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_63436">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_63299"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_63551"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018038"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33720"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#has_functional_parent"/>
@@ -10004,6 +10545,18 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_63551">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_29067"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_63436"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018038"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33721"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#has_functional_parent"/>
@@ -10069,6 +10622,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_64708">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_50860"/>
         <obo:IAO_0000115>An organic molecular entity containing a single carbon atom (C1).</obo:IAO_0000115>
+        <obo:IAO_0000115>An organic molecular entity containing a single carbon atom (C&lt;small&gt;&lt;sub&gt;1&lt;/sub&gt;&lt;/small&gt;).</obo:IAO_0000115>
         <rdfs:label>one-carbon compound</rdfs:label>
     </owl:Class>
     
@@ -10108,6 +10662,12 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_64769">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_64766"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33247"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
@@ -10124,6 +10684,12 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_64775">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_64767"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33247"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of"/>
@@ -10140,6 +10706,12 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_64898">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_64775"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33708"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of"/>
@@ -10168,6 +10740,12 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_167559"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33694"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_63299"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018038"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_18154"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#has_functional_parent"/>
@@ -10206,6 +10784,12 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_65296">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_25697"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35274"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_50994"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
@@ -10234,11 +10818,11 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_37022"/>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33707"/>
             </owl:Restriction>
         </rdfs:subClassOf>
-        <obo:IAO_0000115>An amino-acid anion in which the amino group is situated gamma- to the carboxylate group.</obo:IAO_0000115>
+        <obo:IAO_0000115>An amino-acid anion in which the amino group is situated γ- to the carboxylate group.</obo:IAO_0000115>
         <rdfs:label>gamma-amino acid anion</rdfs:label>
     </owl:Class>
     
@@ -10256,11 +10840,17 @@ For example, A and B may be gene products and binding of B by A positively regul
         </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018034"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_18357"/>
             </owl:Restriction>
         </rdfs:subClassOf>
-        <obo:IAO_0000115>An organic cation that is the conjugate acid of (R)-noradrenaline, obtained by protonation of the priamry amino group; major species at pH 7.3.</obo:IAO_0000115>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018039"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_234420"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
+        <obo:IAO_0000115>An organic cation that is the conjugate acid of (&lt;i&gt;R&lt;/i&gt;)-noradrenaline, obtained by protonation of the primary amino group; major species at pH 7.3.</obo:IAO_0000115>
         <rdfs:label>(R)-noradrenaline(1+)</rdfs:label>
     </owl:Class>
     
@@ -10311,7 +10901,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_75600">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_75603"/>
-        <obo:IAO_0000115>A ligase inhibitor that interferes with the action of a C-N bond-forming ligase (EC 6.3.*.*).</obo:IAO_0000115>
+        <obo:IAO_0000115>A ligase inhibitor that interferes with the action of a &lt;em&gt;C&lt;/em&gt;‒&lt;em&gt;N&lt;/em&gt; bond-forming ligase (EC 6.3.*.*).</obo:IAO_0000115>
         <rdfs:label>EC 6.3.* (C-N bond-forming ligase) inhibitor</rdfs:label>
     </owl:Class>
     
@@ -10361,6 +10951,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_75771">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_75768"/>
+        <obo:IAO_0000115>Any mammalian metabolite produced during a metabolic reaction in a mouse (&lt;em&gt;Mus musculus&lt;/em&gt;).</obo:IAO_0000115>
         <obo:IAO_0000115>Any mammalian metabolite produced during a metabolic reaction in a mouse (Mus musculus).</obo:IAO_0000115>
         <rdfs:label>mouse metabolite</rdfs:label>
     </owl:Class>
@@ -10371,6 +10962,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_75772">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_76946"/>
+        <obo:IAO_0000115>Any  fungal metabolite produced during a metabolic reaction in Baker&apos;s yeast (&lt;em&gt;Saccharomyces cerevisiae &lt;/em&gt;).</obo:IAO_0000115>
         <obo:IAO_0000115>Any  fungal metabolite produced during a metabolic reaction in Baker&apos;s yeast (Saccharomyces cerevisiae).</obo:IAO_0000115>
         <rdfs:label>Saccharomyces cerevisiae metabolite</rdfs:label>
     </owl:Class>
@@ -10431,7 +11023,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_76823">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_75600"/>
-        <obo:IAO_0000115>An EC 6.3.* (C-N bond-forming ligase) inhibitor that interferes with the action of any acid-ammonia (or amine) ligase (EC 6.3.1.*).</obo:IAO_0000115>
+        <obo:IAO_0000115>An EC 6.3.* (&lt;em&gt;C&lt;/em&gt;‒&lt;em&gt;N&lt;/em&gt; bond-forming ligase) inhibitor that interferes with the action of any acid-ammonia (or amine) ligase (EC 6.3.1.*).</obo:IAO_0000115>
         <rdfs:label>EC 6.3.1.* (acid-ammonia/amine ligase) inhibitor</rdfs:label>
     </owl:Class>
     
@@ -10482,6 +11074,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_76971">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_76969"/>
+        <obo:IAO_0000115>Any bacterial metabolite produced during a metabolic reaction in &lt;em&gt;Escherichia coli&lt;/em&gt;.</obo:IAO_0000115>
         <obo:IAO_0000115>Any bacterial metabolite produced during a metabolic reaction in Escherichia coli.</obo:IAO_0000115>
         <rdfs:label>Escherichia coli metabolite</rdfs:label>
     </owl:Class>
@@ -10492,6 +11085,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_77746">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_75768"/>
+        <obo:IAO_0000115>Any mammalian metabolite  produced during a metabolic reaction in humans (&lt;em&gt;Homo sapiens&lt;/em&gt;).</obo:IAO_0000115>
         <obo:IAO_0000115>Any mammalian metabolite  produced during a metabolic reaction in humans (Homo sapiens).</obo:IAO_0000115>
         <rdfs:label>human metabolite</rdfs:label>
     </owl:Class>
@@ -10525,7 +11119,7 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_58953"/>
         <rdfs:subClassOf>
             <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of"/>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018033"/>
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_140601"/>
             </owl:Restriction>
         </rdfs:subClassOf>
@@ -10559,6 +11153,12 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_78608">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35238"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0018036"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33704"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_tautomer_of"/>
@@ -10566,6 +11166,7 @@ For example, A and B may be gene products and binding of B by A positively regul
             </owl:Restriction>
         </rdfs:subClassOf>
         <obo:IAO_0000115>An amino acid-zwitterion obtained by transfer of a proton from the carboxy to the amino group of any alpha-amino acid; major species at pH 7.3.</obo:IAO_0000115>
+        <obo:IAO_0000115>An amino acid-zwitterion obtained by transfer of a proton from the carboxy to the amino group of any α-amino acid; major species at pH 7.3.</obo:IAO_0000115>
         <rdfs:label>alpha-amino-acid zwitterion</rdfs:label>
     </owl:Class>
     
@@ -10575,6 +11176,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_78616">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_36963"/>
+        <obo:IAO_0000115>Any organooxygen compound that is a polyhydroxy-aldehyde or -ketone, or a compound derived from one. Carbohydrates contain only carbon, hydrogen and oxygen and usually have an empirical formula C&lt;small&gt;&lt;sub&gt;&lt;em&gt;m&lt;/em&gt;&lt;/sub&gt;&lt;/small&gt;(H&lt;small&gt;&lt;sub&gt;2&lt;/sub&gt;&lt;/small&gt;O)&lt;small&gt;&lt;sub&gt;&lt;em&gt;n&lt;/em&gt;&lt;/sub&gt;&lt;/small&gt;; carbohydrate derivatives may contain other elements by substitution or condensation.</obo:IAO_0000115>
         <obo:IAO_0000115>Any organooxygen compound that is a polyhydroxy-aldehyde or -ketone, or a compound derived from one. Carbohydrates contain only carbon, hydrogen and oxygen and usually have an empirical formula Cm(H2O)n; carbohydrate derivatives may contain other elements by substitution or condensation.</obo:IAO_0000115>
         <rdfs:label>carbohydrates and carbohydrate derivatives</rdfs:label>
     </owl:Class>
@@ -10625,6 +11227,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_83056">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_83057"/>
+        <obo:IAO_0000115>A &lt;em&gt;Daphnia&lt;/em&gt; metabolite produced by the species &lt;em&gt;Daphnia magna&lt;/em&gt;.</obo:IAO_0000115>
         <obo:IAO_0000115>A Daphnia metabolite produced by the species Daphnia magna.</obo:IAO_0000115>
         <rdfs:label>Daphnia magna metabolite</rdfs:label>
     </owl:Class>
@@ -10635,6 +11238,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_83057">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_83039"/>
+        <obo:IAO_0000115>A crustacean metabolite produced by the genus of small planktonic arthropods, &lt;em&gt;Daphnia&lt;/em&gt;</obo:IAO_0000115>
         <obo:IAO_0000115>A crustacean metabolite produced by the genus of small planktonic arthropods, Daphnia</obo:IAO_0000115>
         <rdfs:label>Daphnia metabolite</rdfs:label>
     </owl:Class>
@@ -10645,7 +11249,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_83813">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33709"/>
-        <obo:IAO_0000115>Any of the 23 alpha-amino acids that are precursors to proteins, and are incorporated into proteins during translation. The group includes the 20 amino acids encoded by the nuclear genes of eukaryotes together with selenocysteine, pyrrolysine, and N-formylmethionine. Apart from glycine, which is non-chiral, all have L configuration.</obo:IAO_0000115>
+        <obo:IAO_0000115>Any of the 23 α-amino acids that are precursors to proteins, and are incorporated into proteins during translation. The group includes the 20 amino acids encoded by the nuclear genes of eukaryotes together with selenocysteine, pyrrolysine, and &lt;em&gt;N&lt;/em&gt;-formylmethionine. Apart from glycine, which is non-chiral, all have &lt;small&gt;L&lt;/small&gt; configuration.</obo:IAO_0000115>
         <rdfs:label>proteinogenic amino acid</rdfs:label>
     </owl:Class>
     
@@ -10666,7 +11270,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_83925">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33704"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_83820"/>
-        <obo:IAO_0000115>Any  alpha-amino acid which is not a member of the group of 23 proteinogenic amino acids.</obo:IAO_0000115>
+        <obo:IAO_0000115>Any  α-amino acid which is not a member of the group of 23 proteinogenic amino acids.</obo:IAO_0000115>
         <rdfs:label>non-proteinogenic alpha-amino acid</rdfs:label>
     </owl:Class>
     
@@ -10730,6 +11334,7 @@ For example, A and B may be gene products and binding of B by A positively regul
         <owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/GO_0031012"/>
         <owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/GO_0032991"/>
         <owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/GO_0043226"/>
+        <owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/GO_0044423"/>
         <obo:IAO_0000115>A material entity of anatomical origin (part of or deriving from an organism) that has as its parts a maximally connected cell compartment surrounded by a plasma membrane.</obo:IAO_0000115>
         <rdfs:label>cell</rdfs:label>
     </owl:Class>
@@ -12592,6 +13197,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/CL_0000138">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CL_0000153"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CL_0000667"/>
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CL_0007001"/>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0001025"/>
@@ -27526,7 +28132,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000006">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s body (typically defined by its center point or a significant portion) fully enters the user-defined zone designated as &apos;Open Arm (North)&apos;. The &apos;Open Arm (North)&apos; is one of the two open arms, distinguished by its assigned &apos;north&apos; orientation or designation in the experimental setup. Unit of measure: count</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s body (typically defined by its center point or a significant portion) fully enters the user-defined zone designated as &apos;Open Arm (North)&apos;. The &apos;Open Arm (North)&apos; is one of the two open arms, distinguished by its assigned &apos;north&apos; orientation or designation in the experimental setup. Unit: count</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: open arm (north) - entries</rdfs:label>
     </owl:Class>
     
@@ -27536,7 +28142,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000007">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s body (typically defined by its center point or a significant portion) fully enters the user-defined zone designated as &apos;Open Arm (South)&apos;. The &apos;Open Arm (South)&apos; is one of the two open arms, distinguished by its assigned &apos;south&apos; orientation or designation in the experimental setup. Unit of measure: count</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s body (typically defined by its center point or a significant portion) fully enters the user-defined zone designated as &apos;Open Arm (South)&apos;. The &apos;Open Arm (South)&apos; is one of the two open arms, distinguished by its assigned &apos;south&apos; orientation or designation in the experimental setup. Unit: count</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: open arm (south) - entries</rdfs:label>
     </owl:Class>
     
@@ -27546,7 +28152,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000008">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this represents the total number of times the animal&apos;s body (typically defined by its center point or a significant portion) fully enters the designated open arm zones (e.g., &apos;Open Arm (North)&apos; and &apos;Open Arm (South)&apos;). It is a common measure of exploration and anxiety. Unit of measure: count</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this represents the total number of times the animal&apos;s body (typically defined by its center point or a significant portion) fully enters the designated open arm zones (e.g., &apos;Open Arm (North)&apos; and &apos;Open Arm (South)&apos;). It is a common measure of exploration and anxiety. Unit: count</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: open arm total entries</rdfs:label>
     </owl:Class>
     
@@ -27556,7 +28162,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000009">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s head (specifically tracked by the software) enters the user-defined &apos;Open Arm (North)&apos; zone, irrespective of full body entry. This can indicate risk assessment or tentative exploration of the arm designated as &apos;north&apos;. Unit of measure: count</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s head (specifically tracked by the software) enters the user-defined &apos;Open Arm (North)&apos; zone, irrespective of full body entry. This can indicate risk assessment or tentative exploration of the arm designated as &apos;north&apos;. Unit: count</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: open arm (north) - head entries</rdfs:label>
     </owl:Class>
     
@@ -27566,7 +28172,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000010">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s head (specifically tracked by the software) enters the user-defined &apos;Open Arm (South)&apos; zone, irrespective of full body entry, often reflecting cautious exploration of the open arm designated as &apos;south&apos;. Unit of measure: count</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s head (specifically tracked by the software) enters the user-defined &apos;Open Arm (South)&apos; zone, irrespective of full body entry, often reflecting cautious exploration of the open arm designated as &apos;south&apos;. Unit: count</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: open arm (south) - head entries</rdfs:label>
     </owl:Class>
     
@@ -27576,7 +28182,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000011">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the total number of times the animal&apos;s head (specifically tracked by the software) enters any of the designated open arm zones (e.g., &apos;Open Arm (North)&apos; and &apos;Open Arm (South)&apos;), considered an indicator of risk-assessment behavior. Unit of measure: count</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the total number of times the animal&apos;s head (specifically tracked by the software) enters any of the designated open arm zones (e.g., &apos;Open Arm (North)&apos; and &apos;Open Arm (South)&apos;), considered an indicator of risk-assessment behavior. Unit: count</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: open arm total head entries</rdfs:label>
     </owl:Class>
     
@@ -27587,7 +28193,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000012">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal&apos;s body spends within the user-defined &apos;Open Arm (North)&apos; zone. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal&apos;s body spends within the user-defined &apos;Open Arm (North)&apos; zone. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: open arm (north) - time</rdfs:label>
     </owl:Class>
     
@@ -27598,7 +28204,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000013">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal&apos;s body spends within the user-defined &apos;Open Arm (South)&apos; zone. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal&apos;s body spends within the user-defined &apos;Open Arm (South)&apos; zone. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: open arm (south) - time</rdfs:label>
     </owl:Class>
     
@@ -27609,7 +28215,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000014">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the cumulative total duration the animal&apos;s body spends within any of the designated open arm zones (e.g., &apos;Open Arm (North)&apos; and &apos;Open Arm (South)&apos;). Less time is generally indicative of higher anxiety. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the cumulative total duration the animal&apos;s body spends within any of the designated open arm zones (e.g., &apos;Open Arm (North)&apos; and &apos;Open Arm (South)&apos;). Less time is generally indicative of higher anxiety. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: open arm total time</rdfs:label>
     </owl:Class>
     
@@ -27619,7 +28225,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000015">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this represents the percentage of the total test duration that the animal spends in any of the designated open arm zones (e.g., &apos;Open Arm (North)&apos; and &apos;Open Arm (South)&apos;). Unit of measure: %</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this represents the percentage of the total test duration that the animal spends in any of the designated open arm zones (e.g., &apos;Open Arm (North)&apos; and &apos;Open Arm (South)&apos;). Unit: %</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: open arm total - percent time during test duration</rdfs:label>
     </owl:Class>
     
@@ -27630,7 +28236,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000016">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000091"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined &apos;Open Arm (North)&apos; zone. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined &apos;Open Arm (North)&apos; zone. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: open arm (north) - latency to first entry</rdfs:label>
     </owl:Class>
     
@@ -27641,7 +28247,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000017">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000091"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined &apos;Open Arm (South)&apos; zone. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined &apos;Open Arm (South)&apos; zone. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: open arm (south) - latency to first entry</rdfs:label>
     </owl:Class>
     
@@ -27652,7 +28258,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000018">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000091"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into any of the designated open arm zones (e.g., &apos;Open Arm (North)&apos; or &apos;Open Arm (South)&apos;). Longer latencies often suggest higher anxiety. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into any of the designated open arm zones (e.g., &apos;Open Arm (North)&apos; or &apos;Open Arm (South)&apos;). Longer latencies often suggest higher anxiety. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: open arm total latency to first entry</rdfs:label>
     </owl:Class>
     
@@ -27663,7 +28269,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000019">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined &apos;Open Arm (North)&apos; zone, as detected by the tracking software. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined &apos;Open Arm (North)&apos; zone, as detected by the tracking software. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: open arm (north) - time moving towards</rdfs:label>
     </owl:Class>
     
@@ -27674,7 +28280,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000020">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined &apos;Open Arm (South)&apos; zone, as detected by the tracking software. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined &apos;Open Arm (South)&apos; zone, as detected by the tracking software. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: open arm (south) - time moving towards</rdfs:label>
     </owl:Class>
     
@@ -27685,7 +28291,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000021">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the cumulative duration the animal spends actively moving towards any of the designated open arm zones (e.g., &apos;Open Arm (North)&apos; or &apos;Open Arm (South)&apos;), reflecting approach motivation. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the cumulative duration the animal spends actively moving towards any of the designated open arm zones (e.g., &apos;Open Arm (North)&apos; or &apos;Open Arm (South)&apos;), reflecting approach motivation. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: open arm total time moving towards</rdfs:label>
     </owl:Class>
     
@@ -27696,7 +28302,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000022">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior (a state of immobility except for respiratory movements) while within the user-defined &apos;Open Arm (North)&apos; zone. Freezing is a common fear response. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior (a state of immobility except for respiratory movements) while within the user-defined &apos;Open Arm (North)&apos; zone. Freezing is a common fear response. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: open arm (north) - time freezing</rdfs:label>
     </owl:Class>
     
@@ -27707,7 +28313,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000023">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined &apos;Open Arm (South)&apos; zone. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined &apos;Open Arm (South)&apos; zone. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: open arm (south) - time freezing</rdfs:label>
     </owl:Class>
     
@@ -27718,7 +28324,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000024">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the cumulative duration the animal exhibits freezing behavior while within any of the designated open arm zones (e.g., &apos;Open Arm (North)&apos; or &apos;Open Arm (South)&apos;), indicating fear or anxiety. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the cumulative duration the animal exhibits freezing behavior while within any of the designated open arm zones (e.g., &apos;Open Arm (North)&apos; or &apos;Open Arm (South)&apos;), indicating fear or anxiety. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: open arm total time freezing</rdfs:label>
     </owl:Class>
     
@@ -27728,7 +28334,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000025">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s body fully enters the user-defined &apos;Closed Arm (West)&apos; zone, representing the enclosed arm designated as &apos;west&apos;. Unit of measure: count</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s body fully enters the user-defined &apos;Closed Arm (West)&apos; zone, representing the enclosed arm designated as &apos;west&apos;. Unit: count</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: closed arm (west) - entries</rdfs:label>
     </owl:Class>
     
@@ -27738,7 +28344,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000026">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s body fully enters the user-defined &apos;Closed Arm (East)&apos; zone, representing the enclosed arm designated as &apos;east&apos;. Unit of measure: count</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s body fully enters the user-defined &apos;Closed Arm (East)&apos; zone, representing the enclosed arm designated as &apos;east&apos;. Unit: count</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: closed arm (east) - entries</rdfs:label>
     </owl:Class>
     
@@ -27748,7 +28354,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000027">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the total number of times the animal&apos;s body fully enters any of the designated closed arm zones (e.g., &apos;Closed Arm (West)&apos; and &apos;Closed Arm (East)&apos;). It is often used as an indicator of general locomotor activity. Unit of measure: count</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the total number of times the animal&apos;s body fully enters any of the designated closed arm zones (e.g., &apos;Closed Arm (West)&apos; and &apos;Closed Arm (East)&apos;). It is often used as an indicator of general locomotor activity. Unit: count</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: closed arm total entries</rdfs:label>
     </owl:Class>
     
@@ -27758,7 +28364,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000028">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s head enters the user-defined &apos;Closed Arm (West)&apos; zone. Unit of measure: count</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s head enters the user-defined &apos;Closed Arm (West)&apos; zone. Unit: count</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: closed arm (west) - head entries</rdfs:label>
     </owl:Class>
     
@@ -27768,7 +28374,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000029">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s head enters the user-defined &apos;Closed Arm (East)&apos; zone. Unit of measure: count</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s head enters the user-defined &apos;Closed Arm (East)&apos; zone. Unit: count</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: closed arm (east) - head entries</rdfs:label>
     </owl:Class>
     
@@ -27778,7 +28384,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000030">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the total number of times the animal&apos;s head enters any of the designated closed arm zones (e.g., &apos;Closed Arm (West)&apos; and &apos;Closed Arm (East)&apos;). Unit of measure: count</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the total number of times the animal&apos;s head enters any of the designated closed arm zones (e.g., &apos;Closed Arm (West)&apos; and &apos;Closed Arm (East)&apos;). Unit: count</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: closed arm total head entries</rdfs:label>
     </owl:Class>
     
@@ -27789,7 +28395,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000031">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal&apos;s body spends within the user-defined &apos;Closed Arm (West)&apos; zone. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal&apos;s body spends within the user-defined &apos;Closed Arm (West)&apos; zone. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: closed arm (west) - time</rdfs:label>
     </owl:Class>
     
@@ -27800,7 +28406,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000032">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal&apos;s body spends within the user-defined &apos;Closed Arm (East)&apos; zone. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal&apos;s body spends within the user-defined &apos;Closed Arm (East)&apos; zone. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: closed arm (east) - time</rdfs:label>
     </owl:Class>
     
@@ -27811,7 +28417,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000033">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the cumulative total duration the animal&apos;s body spends within any of the designated closed arm zones (e.g., &apos;Closed Arm (West)&apos; and &apos;Closed Arm (East)&apos;). Animals typically spend more time in these &apos;safer&apos; areas. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the cumulative total duration the animal&apos;s body spends within any of the designated closed arm zones (e.g., &apos;Closed Arm (West)&apos; and &apos;Closed Arm (East)&apos;). Animals typically spend more time in these &apos;safer&apos; areas. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: closed arm total time</rdfs:label>
     </owl:Class>
     
@@ -27821,7 +28427,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000034">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this represents the percentage of the total test duration that the animal spends in any of the designated closed arm zones (e.g., &apos;Closed Arm (West)&apos; and &apos;Closed Arm (East)&apos;). Unit of measure: %</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this represents the percentage of the total test duration that the animal spends in any of the designated closed arm zones (e.g., &apos;Closed Arm (West)&apos; and &apos;Closed Arm (East)&apos;). Unit: %</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: closed arm total - percent time during test duration</rdfs:label>
     </owl:Class>
     
@@ -27832,7 +28438,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000035">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000091"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined &apos;Closed Arm (West)&apos; zone. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined &apos;Closed Arm (West)&apos; zone. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: closed arm (west) - latency to first entry</rdfs:label>
     </owl:Class>
     
@@ -27843,7 +28449,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000036">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000091"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined &apos;Closed Arm (East)&apos; zone. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined &apos;Closed Arm (East)&apos; zone. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: closed arm (east) - latency to first entry</rdfs:label>
     </owl:Class>
     
@@ -27854,7 +28460,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000037">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000091"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into any of the designated closed arm zones (e.g., &apos;Closed Arm (West)&apos; or &apos;Closed Arm (East)&apos;). Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into any of the designated closed arm zones (e.g., &apos;Closed Arm (West)&apos; or &apos;Closed Arm (East)&apos;). Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: closed arm total latency to first entry</rdfs:label>
     </owl:Class>
     
@@ -27865,7 +28471,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000038">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined &apos;Closed Arm (West)&apos; zone. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined &apos;Closed Arm (West)&apos; zone. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: closed arm (west) - time moving towards</rdfs:label>
     </owl:Class>
     
@@ -27876,7 +28482,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000039">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined &apos;Closed Arm (East)&apos; zone. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined &apos;Closed Arm (East)&apos; zone. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: closed arm (east) - time moving towards</rdfs:label>
     </owl:Class>
     
@@ -27887,7 +28493,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000040">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the cumulative duration the animal spends actively moving towards any of the designated closed arm zones (e.g., &apos;Closed Arm (West)&apos; or &apos;Closed Arm (East)&apos;). Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the cumulative duration the animal spends actively moving towards any of the designated closed arm zones (e.g., &apos;Closed Arm (West)&apos; or &apos;Closed Arm (East)&apos;). Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: closed arm total time moving towards</rdfs:label>
     </owl:Class>
     
@@ -27898,7 +28504,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000041">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined &apos;Closed Arm (West)&apos; zone. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined &apos;Closed Arm (West)&apos; zone. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: closed arm (west) - time freezing</rdfs:label>
     </owl:Class>
     
@@ -27909,7 +28515,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000042">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined &apos;Closed Arm (East)&apos; zone. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined &apos;Closed Arm (East)&apos; zone. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: closed arm (east) - time freezing</rdfs:label>
     </owl:Class>
     
@@ -27920,7 +28526,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000043">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the cumulative duration the animal exhibits freezing behavior while within any of the designated closed arm zones (e.g., &apos;Closed Arm (West)&apos; or &apos;Closed Arm (East)&apos;). Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the cumulative duration the animal exhibits freezing behavior while within any of the designated closed arm zones (e.g., &apos;Closed Arm (West)&apos; or &apos;Closed Arm (East)&apos;). Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: closed arm total time freezing</rdfs:label>
     </owl:Class>
     
@@ -27930,7 +28536,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000044">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s body fully enters the user-defined &apos;Center&apos; zone of the maze, typically from one of the arms. The center zone is the area where all four arms meet. Unit of measure: count</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s body fully enters the user-defined &apos;Center&apos; zone of the maze, typically from one of the arms. The center zone is the area where all four arms meet. Unit: count</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: center - entries</rdfs:label>
     </owl:Class>
     
@@ -27940,7 +28546,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000045">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s head enters the user-defined &apos;Center&apos; zone of the maze. Unit of measure: count</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this counts the number of times the animal&apos;s head enters the user-defined &apos;Center&apos; zone of the maze. Unit: count</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: center - head entries</rdfs:label>
     </owl:Class>
     
@@ -27951,7 +28557,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000046">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal&apos;s body spends within the user-defined &apos;Center&apos; zone. Time in the center can indicate decision-making or risk assessment. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal&apos;s body spends within the user-defined &apos;Center&apos; zone. Time in the center can indicate decision-making or risk assessment. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: center - time</rdfs:label>
     </owl:Class>
     
@@ -27961,7 +28567,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000047">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this represents the percentage of the total test duration that the animal spends in the user-defined &apos;Center&apos; zone of the maze. Unit of measure: %</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this represents the percentage of the total test duration that the animal spends in the user-defined &apos;Center&apos; zone of the maze. Unit: %</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: center - percent time during test duration</rdfs:label>
     </owl:Class>
     
@@ -27972,7 +28578,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000048">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000091"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined &apos;Center&apos; zone. If the animal starts in the center, this value may be zero or not applicable. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined &apos;Center&apos; zone. If the animal starts in the center, this value may be zero or not applicable. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: center - latency to first entry</rdfs:label>
     </owl:Class>
     
@@ -27983,7 +28589,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000049">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined &apos;Center&apos; zone of the maze (e.g., from an arm). Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined &apos;Center&apos; zone of the maze (e.g., from an arm). Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: center - time moving towards</rdfs:label>
     </owl:Class>
     
@@ -27994,7 +28600,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000050">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined &apos;Center&apos; zone of the maze. Freezing in this relatively exposed area can indicate high anxiety. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined &apos;Center&apos; zone of the maze. Freezing in this relatively exposed area can indicate high anxiety. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: center - time freezing</rdfs:label>
     </owl:Class>
     
@@ -28025,7 +28631,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000053">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000004"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000162"/>
-        <obo:IAO_0000115>In the Fear-potentiated startle paradigm, this is the amplitude of the acoustic startle response (ASR) measured in response to a startle-eliciting stimulus (e.g., 95-dB white noise burst) prior to any fear conditioning procedures, typically assessed during habituation or pre-conditioning phase. This measurement serves as a reference point for later comparisons with post-conditioning startle responses. Unit of measure: arbitrary units or standardized score.</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Fear-potentiated startle paradigm, this is the amplitude of the acoustic startle response (ASR) measured in response to a startle-eliciting stimulus (e.g., 95-dB white noise burst) prior to any fear conditioning procedures, typically assessed during habituation or pre-conditioning phase. This measurement serves as a reference point for later comparisons with post-conditioning startle responses. Unit: arbitrary units or standardized score.</obo:IAO_0000115>
         <rdfs:label xml:lang="en">fear-potentiated startle: baseline acoustic startle response amplitude</rdfs:label>
     </owl:Class>
     
@@ -28076,7 +28682,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000058">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000093"/>
-        <obo:IAO_0000115>Identifier for the specific Plexiglas enclosure or sound-attenuating chamber within the Fear-Potentiated Startle (FPS) apparatus (e.g., San Diego Instruments SR-Lab) in which a subject was tested for a given trial. Unit of measure: count or identifier string</obo:IAO_0000115>
+        <obo:IAO_0000115>Identifier for the specific Plexiglas enclosure or sound-attenuating chamber within the Fear-Potentiated Startle (FPS) apparatus (e.g., San Diego Instruments SR-Lab) in which a subject was tested for a given trial. Unit: count or identifier string</obo:IAO_0000115>
         <rdfs:label xml:lang="en">fear-potentiated startle: apparatus chamber identifier</rdfs:label>
     </owl:Class>
     
@@ -28096,7 +28702,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000060">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000093"/>
-        <obo:IAO_0000115>The total number of data points (samples) recorded and analyzed for a single acoustic startle response, typically within a defined time window following stimulus onset (e.g., a 200-ms window as mentioned in the manuscript). Unit of measure: count</obo:IAO_0000115>
+        <obo:IAO_0000115>The total number of data points (samples) recorded and analyzed for a single acoustic startle response, typically within a defined time window following stimulus onset (e.g., a 200-ms window as mentioned in the manuscript). Unit: count</obo:IAO_0000115>
         <rdfs:label xml:lang="en">acoustic startle response: number of samples</rdfs:label>
     </owl:Class>
     
@@ -28106,7 +28712,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000061">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000093"/>
-        <obo:IAO_0000115>The rate at which the analog startle response signal was digitized during data acquisition. Unit of measure: Hertz (Hz)</obo:IAO_0000115>
+        <obo:IAO_0000115>The rate at which the analog startle response signal was digitized during data acquisition. Unit: Hertz (Hz)</obo:IAO_0000115>
         <rdfs:label xml:lang="en">acoustic startle response: sampling rate</rdfs:label>
     </owl:Class>
     
@@ -28117,7 +28723,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000062">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000004"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000162"/>
-        <obo:IAO_0000115>The amplitude of the digitized acoustic startle response signal at the very beginning (onset) of the defined analysis window (e.g., a 200-ms window) used to quantify the reflex. Unit of measure: millivolts (mV) or arbitrary units based on transducer calibration.</obo:IAO_0000115>
+        <obo:IAO_0000115>The amplitude of the digitized acoustic startle response signal at the very beginning (onset) of the defined analysis window (e.g., a 200-ms window) used to quantify the reflex. Unit: millivolts (mV) or arbitrary units based on transducer calibration.</obo:IAO_0000115>
         <rdfs:label xml:lang="en">acoustic startle response: startle window onset amplitude</rdfs:label>
     </owl:Class>
     
@@ -28128,7 +28734,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000063">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000004"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000162"/>
-        <obo:IAO_0000115>The peak amplitude of the acoustic startle response (e.g., &apos;jump amplitude&apos;) detected within the defined analysis window (e.g., 200-ms window) for a given trial. Unit of measure: millivolts (mV) or arbitrary units.</obo:IAO_0000115>
+        <obo:IAO_0000115>The peak amplitude of the acoustic startle response (e.g., &apos;jump amplitude&apos;) detected within the defined analysis window (e.g., 200-ms window) for a given trial. Unit: millivolts (mV) or arbitrary units.</obo:IAO_0000115>
         <rdfs:label xml:lang="en">acoustic startle response: maximum amplitude</rdfs:label>
     </owl:Class>
     
@@ -28139,7 +28745,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000064">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000004"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000091"/>
-        <obo:IAO_0000115>The latency from the onset of the startle-eliciting stimulus (or the beginning of the analysis window) to the occurrence of the maximum (peak) amplitude of the acoustic startle response. Unit of measure: milliseconds (ms)</obo:IAO_0000115>
+        <obo:IAO_0000115>The latency from the onset of the startle-eliciting stimulus (or the beginning of the analysis window) to the occurrence of the maximum (peak) amplitude of the acoustic startle response. Unit: milliseconds (ms)</obo:IAO_0000115>
         <rdfs:label xml:lang="en">acoustic startle response: time to maximum amplitude</rdfs:label>
     </owl:Class>
     
@@ -28150,7 +28756,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000065">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000004"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000162"/>
-        <obo:IAO_0000115>The average amplitude of the digitized acoustic startle response signal calculated across the entire duration of the defined analysis window (e.g., 200-ms window). Unit of measure: millivolts (mV) or arbitrary units.</obo:IAO_0000115>
+        <obo:IAO_0000115>The average amplitude of the digitized acoustic startle response signal calculated across the entire duration of the defined analysis window (e.g., 200-ms window). Unit: millivolts (mV) or arbitrary units.</obo:IAO_0000115>
         <rdfs:label xml:lang="en">acoustic startle response: average amplitude</rdfs:label>
     </owl:Class>
     
@@ -28183,7 +28789,7 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000003"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000090"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000092"/>
-        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the time of the total test duration in seconds&apos;). Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the Elevated Plus Maze task, this is the time of the total test duration in seconds&apos;). Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">elevated plus maze: test duration</rdfs:label>
     </owl:Class>
     
@@ -29313,7 +29919,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000175">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000163"/>
-        <obo:IAO_0000115>The number of seconds the individual spent freezing during a given period of time. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>The number of seconds the individual spent freezing during a given period of time. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">contextual fear conditioning: time freezing</rdfs:label>
     </owl:Class>
     
@@ -29324,7 +29930,7 @@ For example, A and B may be gene products and binding of B by A positively regul
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000176">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000163"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000164"/>
-        <obo:IAO_0000115>In the contextual fear conditioning paradigm, this is the time of the block duration in seconds. Unit of measure: seconds</obo:IAO_0000115>
+        <obo:IAO_0000115>In the contextual fear conditioning paradigm, this is the time of the block duration in seconds. Unit: seconds</obo:IAO_0000115>
         <rdfs:label xml:lang="en">contextual fear conditioning: block duration</rdfs:label>
     </owl:Class>
     
@@ -29882,6 +30488,287 @@ For example, A and B may be gene products and binding of B by A positively regul
     
 
 
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000231 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000231">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000101"/>
+        <obo:IAO_0000115>A parameter that specifies the technical settings, environmental conditions, or experimental design of a chemotaxis assay involving Caenorhabditis elegans.</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">C. elegans chemotaxis assay parameter</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000232 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000232">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000231"/>
+        <obo:IAO_0000115>A table containing the quantities and identities of all chemicals used as a chemoattractant (e.g., isoamyl alcohol, diacetyl) to elicit a directed movement response in C. elegans.</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">C. elegans chemotaxis assay parameter: chemoattractant mixture table</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000233 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000233">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000231"/>
+        <obo:IAO_0000115>The volume of the chemoattractant mixture pipetted onto the agar plate in a chemotaxis assay. Unit: microliters (μL).</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">C. elegans chemotaxis assay parameter: chemoattractant mixture volume</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000234 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000234">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000231"/>
+        <obo:IAO_0000115>The total time elapsed from the point at which C. elegans are placed on the assay plate until the movement is arrested or the final positions are recorded. Unit: minutes.</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">C. elegans chemotaxis assay parameter: assay duration</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000235 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000235">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000100"/>
+        <obo:IAO_0000115>A quantitative or qualitative value derived from a C. elegans chemotaxis assay, typically describing the efficiency or directionality of the animals&apos; movement toward or away from a chemical source.</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">C. elegans chemotaxis assay measurement</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000236 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000236">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000235"/>
+        <obo:IAO_0000115>A behavioral measurement of chemotactic efficiency defined as the ratio of the straight-line displacement toward the attractant to the total path length traveled by the organism. Values range from -1 to 1.</obo:IAO_0000115>
+        <oboInOwl:hasExactSynonym xml:lang="en">chemotactic ratio</oboInOwl:hasExactSynonym>
+        <rdfs:label xml:lang="en">C. elegans chemotaxis assay measurement: McCutcheon index</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000237 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000237">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000235"/>
+        <obo:IAO_0000115>The average speed of a C. elegans individual or population during the duration of the chemotaxis assay. Unit: micrometers per second (µm/s).</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">C. elegans chemotaxis assay measurement: mean velocity</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000238 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000238">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000076"/>
+        <obo:IAO_0000115>A specific genetic variant or line of an organism designated by the investigator, often containing unique mutations, transgenes, or genomic edits not yet categorized in a public repository.</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">investigator-defined strain</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000239 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000239">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000238"/>
+        <obo:IAO_0000115>A specific strain of Caenorhabditis elegans, identified by its genotype or a standard nomenclature (e.g., N2, CB4856), used in experimental procedures.</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">C. elegans strain</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000240 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000240">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000239"/>
+        <obo:IAO_0000115>A C. elegans strain with the genotype daf-22 (m130). This strain was originally obtained from the Caenorhabditis Genetics Center (CGC) as strain DR476 and subsequently outcrossed three times. [Source: https://doi.org/TBD]</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">BAB9001</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000241 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000241">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000239"/>
+        <obo:IAO_0000115>A C. elegans klp-6 rescue strain with the genotype klp-6 (my8); Pklp-6::GFP::KLP-6 (array, IndEx 9002). [Source: https://doi.org/TBD]</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">BAB9002</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000242 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000242">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000239"/>
+        <obo:IAO_0000115>A C. elegans strain with the genotype cil-7 (tm5848) I, exhibiting a him phenotype. This strain was obtained from the National BioResource Project (NBRP), Japan. [Source: https://doi.org/TBD]</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">TM5848</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000243 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000243">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000239"/>
+        <obo:IAO_0000115>A C. elegans strain with the genotype cil-7 (my61[cil-7::mNG])I; him-5(e1490) V. This strain was provided as a gift from the Maureen Barr lab. [Source: https://doi.org/TBD]</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">PT3602</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000244 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000244">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000239"/>
+        <obo:IAO_0000115>A C. elegans strain with the genotype PT3602; Pnlp-43_hCaspase nZ (array IndEx 9003). [Source: https://doi.org/TBD]</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">BAB9003</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000245 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000245">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000239"/>
+        <obo:IAO_0000115>A C. elegans strain with the genotype PT3602; Pklp-6_hCaspase Cz (array IndEx 9004). [Source: https://doi.org/TBD]</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">BAB9004</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000246 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000246">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000239"/>
+        <obo:IAO_0000115>A C. elegans strain with the genotype PT3602; Pnlp-43_hCaspase nZ (array IndEx 9003) and Pklp-6_hCaspase Cz (array IndEx 9004). [Source: https://doi.org/TBD]</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">BAB9005</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000247 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000247">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000001"/>
+        <obo:IAO_0000115>fluorescence imaging measurement</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">fluorescence imaging measurement</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000248 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000248">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000247"/>
+        <obo:IAO_0000115>Mean fluorescence intensity. Unit: arbitrary units (AU)</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">mean fluorescence intensity</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000249 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000249">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000247"/>
+        <obo:IAO_0000115>A quantitative measurement of the number of distinct fluorescent spots or puncta detected within a defined region of interest in a fluorescence image. Unit: count</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">fluorescent punctal count</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000250 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000250">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000080"/>
+        <obo:IAO_0000115>A specific parameter related to fluorescence imaging acquisition or assay.</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">fluorescence imaging parameter</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000251 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000251">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000250"/>
+        <obo:IAO_0000115>fluorescence target ontology identifier</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">fluorescence target ontology identifier</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000252 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000252">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000250"/>
+        <obo:IAO_0000115>fluorescence target name</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">fluorescence target name</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000253 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000253">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/format_1929"/>
+        <obo:IAO_0000115>A .dna file format designed for storing annotated DNA sequences, including linear/circular topology, features, primers, and enzyme sites.</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">SnapGene file format</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000254 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000254">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_637912"/>
+        <obo:IAO_0000115>A preparation of Escherichia coli strain OP50 that has been rendered non-viable through the application of heat, typically used as a non-proliferating food source in C. elegans assays.</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">Escherichia coli OP50: heat-killed</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000255 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000255">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000189"/>
+        <obo:IAO_0000115>Method used to transfer C. elegans whereby an M9 buffer is used to wash C. elegans off of an agar plate. Animals can then be transferred using a piper.</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">C. elegans transfer method: M9 buffer wash</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000256 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000256">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000189"/>
+        <obo:IAO_0000115>Method used to transfer C. elegans whereby a titanium pick is used to scoop animals off of an agar plate.</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">C. elegans transfer method: titanium pick</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000257 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000257">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/EMPTY_0000129"/>
+        <obo:IAO_0000115>A video recording capturing the behavior of C. elegans during a chemotaxis assay.</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">C. elegans chemotaxis assay: video recording</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/EMPTY_0000258 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/EMPTY_0000258">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCIT_C16856"/>
+        <obo:IAO_0000115>An image or video acquired using fluorescence microscopy.</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">fluorescence imaging data</rdfs:label>
+    </owl:Class>
+    
+
+
     <!-- http://purl.obolibrary.org/obo/ENVO_00000447 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/ENVO_00000447"/>
@@ -48376,6 +49263,12 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0008150">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0003674"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <oboInOwl:hasExactSynonym>biological process</oboInOwl:hasExactSynonym>
         <oboInOwl:hasExactSynonym>physiological process</oboInOwl:hasExactSynonym>
         <rdfs:label xml:lang="en">biological process</rdfs:label>
@@ -51166,6 +52059,32 @@ For example, A and B may be gene products and binding of B by A positively regul
     
 
 
+    <!-- http://purl.obolibrary.org/obo/GO_0010155 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0010155">
+        <owl:equivalentClass>
+            <owl:Class>
+                <owl:intersectionOf rdf:parseType="Collection">
+                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/GO_0065007"/>
+                    <owl:Restriction>
+                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002211"/>
+                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_1902600"/>
+                    </owl:Restriction>
+                </owl:intersectionOf>
+            </owl:Class>
+        </owl:equivalentClass>
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_1904062"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002211"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_1902600"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
+        <rdfs:label>regulation of proton transport</rdfs:label>
+    </owl:Class>
+    
+
+
     <!-- http://purl.obolibrary.org/obo/GO_0010160 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0010160">
@@ -56875,22 +57794,27 @@ For example, A and B may be gene products and binding of B by A positively regul
     
 
 
-    <!-- http://purl.obolibrary.org/obo/GO_0014878 -->
+    <!-- http://purl.obolibrary.org/obo/GO_0014887 -->
 
-    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0014878">
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0014887">
         <owl:equivalentClass>
             <owl:Class>
                 <owl:intersectionOf rdf:parseType="Collection">
-                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/GO_0051602"/>
+                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/GO_0043500"/>
                     <owl:Restriction>
-                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
-                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0043502"/>
+                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000066"/>
+                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0001133"/>
                     </owl:Restriction>
                 </owl:intersectionOf>
             </owl:Class>
         </owl:equivalentClass>
-        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0014874"/>
-        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0051602"/>
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0014888"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000066"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0001133"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <owl:disjointWith>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002162"/>
@@ -56915,27 +57839,32 @@ For example, A and B may be gene products and binding of B by A positively regul
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_4932"/>
             </owl:Restriction>
         </owl:disjointWith>
-        <rdfs:label>response to electrical stimulus involved in regulation of muscle adaptation</rdfs:label>
+        <rdfs:label>cardiac muscle adaptation</rdfs:label>
     </owl:Class>
     
 
 
-    <!-- http://purl.obolibrary.org/obo/GO_0014879 -->
+    <!-- http://purl.obolibrary.org/obo/GO_0014888 -->
 
-    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0014879">
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0014888">
         <owl:equivalentClass>
             <owl:Class>
                 <owl:intersectionOf rdf:parseType="Collection">
-                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/GO_0050981"/>
+                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/GO_0043500"/>
                     <owl:Restriction>
-                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
-                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0043502"/>
+                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000066"/>
+                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0002036"/>
                     </owl:Restriction>
                 </owl:intersectionOf>
             </owl:Class>
         </owl:equivalentClass>
-        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0014878"/>
-        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0050981"/>
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0043500"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000066"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0002036"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
         <owl:disjointWith>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002162"/>
@@ -56960,32 +57889,27 @@ For example, A and B may be gene products and binding of B by A positively regul
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_4932"/>
             </owl:Restriction>
         </owl:disjointWith>
-        <rdfs:label>detection of electrical stimulus involved in regulation of muscle adaptation</rdfs:label>
+        <rdfs:label>striated muscle adaptation</rdfs:label>
     </owl:Class>
     
 
 
-    <!-- http://purl.obolibrary.org/obo/GO_0014887 -->
+    <!-- http://purl.obolibrary.org/obo/GO_0014895 -->
 
-    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0014887">
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0014895">
         <owl:equivalentClass>
             <owl:Class>
                 <owl:intersectionOf rdf:parseType="Collection">
-                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/GO_0043500"/>
+                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/GO_0014896"/>
                     <owl:Restriction>
                         <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000066"/>
-                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0001133"/>
+                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0001135"/>
                     </owl:Restriction>
                 </owl:intersectionOf>
             </owl:Class>
         </owl:equivalentClass>
-        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0014888"/>
-        <rdfs:subClassOf>
-            <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000066"/>
-                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0001133"/>
-            </owl:Restriction>
-        </rdfs:subClassOf>
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0014805"/>
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0014896"/>
         <owl:disjointWith>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002162"/>
@@ -57010,114 +57934,19 @@ For example, A and B may be gene products and binding of B by A positively regul
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_4932"/>
             </owl:Restriction>
         </owl:disjointWith>
-        <rdfs:label>cardiac muscle adaptation</rdfs:label>
+        <rdfs:label>smooth muscle hypertrophy</rdfs:label>
     </owl:Class>
     
 
 
-    <!-- http://purl.obolibrary.org/obo/GO_0014888 -->
+    <!-- http://purl.obolibrary.org/obo/GO_0014896 -->
 
-    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0014888">
-        <owl:equivalentClass>
-            <owl:Class>
-                <owl:intersectionOf rdf:parseType="Collection">
-                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/GO_0043500"/>
-                    <owl:Restriction>
-                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000066"/>
-                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0002036"/>
-                    </owl:Restriction>
-                </owl:intersectionOf>
-            </owl:Class>
-        </owl:equivalentClass>
-        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0043500"/>
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0014896">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0003012"/>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000066"/>
-                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0002036"/>
-            </owl:Restriction>
-        </rdfs:subClassOf>
-        <owl:disjointWith>
-            <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002162"/>
-                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_2"/>
-            </owl:Restriction>
-        </owl:disjointWith>
-        <owl:disjointWith>
-            <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002162"/>
-                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_2157"/>
-            </owl:Restriction>
-        </owl:disjointWith>
-        <owl:disjointWith>
-            <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002162"/>
-                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_4896"/>
-            </owl:Restriction>
-        </owl:disjointWith>
-        <owl:disjointWith>
-            <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002162"/>
-                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_4932"/>
-            </owl:Restriction>
-        </owl:disjointWith>
-        <rdfs:label>striated muscle adaptation</rdfs:label>
-    </owl:Class>
-    
-
-
-    <!-- http://purl.obolibrary.org/obo/GO_0014895 -->
-
-    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0014895">
-        <owl:equivalentClass>
-            <owl:Class>
-                <owl:intersectionOf rdf:parseType="Collection">
-                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/GO_0014896"/>
-                    <owl:Restriction>
-                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000066"/>
-                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0001135"/>
-                    </owl:Restriction>
-                </owl:intersectionOf>
-            </owl:Class>
-        </owl:equivalentClass>
-        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0014805"/>
-        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0014896"/>
-        <owl:disjointWith>
-            <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002162"/>
-                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_2"/>
-            </owl:Restriction>
-        </owl:disjointWith>
-        <owl:disjointWith>
-            <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002162"/>
-                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_2157"/>
-            </owl:Restriction>
-        </owl:disjointWith>
-        <owl:disjointWith>
-            <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002162"/>
-                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_4896"/>
-            </owl:Restriction>
-        </owl:disjointWith>
-        <owl:disjointWith>
-            <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002162"/>
-                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_4932"/>
-            </owl:Restriction>
-        </owl:disjointWith>
-        <rdfs:label>smooth muscle hypertrophy</rdfs:label>
-    </owl:Class>
-    
-
-
-    <!-- http://purl.obolibrary.org/obo/GO_0014896 -->
-
-    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0014896">
-        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0003012"/>
-        <rdfs:subClassOf>
-            <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000066"/>
-                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0002385"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0002385"/>
             </owl:Restriction>
         </rdfs:subClassOf>
         <owl:disjointWith>
@@ -57441,6 +58270,44 @@ For example, A and B may be gene products and binding of B by A positively regul
     
 
 
+    <!-- http://purl.obolibrary.org/obo/GO_0015078 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0015078">
+        <owl:equivalentClass>
+            <owl:Class>
+                <owl:intersectionOf rdf:parseType="Collection">
+                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/GO_0005215"/>
+                    <owl:Restriction>
+                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002342"/>
+                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0016020"/>
+                    </owl:Restriction>
+                    <owl:Restriction>
+                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0004009"/>
+                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_15378"/>
+                    </owl:Restriction>
+                </owl:intersectionOf>
+            </owl:Class>
+        </owl:equivalentClass>
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0008324"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_1902600"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0004009"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_15378"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
+        <oboInOwl:hasExactSynonym>hydrogen ion transmembrane transporter activity</oboInOwl:hasExactSynonym>
+        <oboInOwl:hasExactSynonym>proton transporter activity</oboInOwl:hasExactSynonym>
+        <rdfs:label>proton transmembrane transporter activity</rdfs:label>
+    </owl:Class>
+    
+
+
     <!-- http://purl.obolibrary.org/obo/GO_0015081 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0015081">
@@ -67878,6 +68745,7 @@ For example, A and B may be gene products and binding of B by A positively regul
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0030312"/>
         <owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/GO_0032991"/>
         <owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/GO_0043226"/>
+        <owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/GO_0044423"/>
         <oboInOwl:hasExactSynonym>proteinaceous extracellular matrix</oboInOwl:hasExactSynonym>
         <rdfs:label>extracellular matrix</rdfs:label>
     </owl:Class>
@@ -72537,6 +73405,7 @@ For example, A and B may be gene products and binding of B by A positively regul
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/PR_000000001"/>
             </owl:Restriction>
         </rdfs:subClassOf>
+        <owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/GO_0044423"/>
         <owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/GO_0110165"/>
         <obo:IAO_0000115>A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.</obo:IAO_0000115>
         <obo:IAO_0000118>protein complex</obo:IAO_0000118>
@@ -80788,6 +81657,7 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0043226">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0110165"/>
+        <owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/GO_0044423"/>
         <rdfs:label>organelle</rdfs:label>
     </owl:Class>
     
@@ -83214,7 +84084,35 @@ For example, A and B may be gene products and binding of B by A positively regul
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0044423">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0005575"/>
+        <rdfs:subClassOf>
+            <owl:Class>
+                <owl:complementOf>
+                    <owl:Restriction>
+                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002162"/>
+                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_131567"/>
+                    </owl:Restriction>
+                </owl:complementOf>
+            </owl:Class>
+        </rdfs:subClassOf>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002162"/>
+                <owl:someValuesFrom>
+                    <owl:Class>
+                        <owl:complementOf rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_131567"/>
+                    </owl:Class>
+                </owl:someValuesFrom>
+            </owl:Restriction>
+        </rdfs:subClassOf>
+        <owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/GO_0110165"/>
+        <owl:disjointWith>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002162"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_131567"/>
+            </owl:Restriction>
+        </owl:disjointWith>
         <obo:IAO_0000115>Any constituent part of a virion, a complete fully infectious extracellular virus particle.</obo:IAO_0000115>
+        <oboInOwl:hasExactSynonym>virion part</oboInOwl:hasExactSynonym>
         <rdfs:label>virion component</rdfs:label>
     </owl:Class>
     
@@ -97021,15 +97919,6 @@ For example, A and B may be gene products and binding of B by A positively regul
     
 
 
-    <!-- http://purl.obolibrary.org/obo/GO_0050952 -->
-
-    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0050952">
-        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0007600"/>
-        <rdfs:label>sensory perception of electrical stimulus</rdfs:label>
-    </owl:Class>
-    
-
-
     <!-- http://purl.obolibrary.org/obo/GO_0050953 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0050953">
@@ -97050,17 +97939,6 @@ For example, A and B may be gene products and binding of B by A positively regul
     
 
 
-    <!-- http://purl.obolibrary.org/obo/GO_0050956 -->
-
-    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0050956">
-        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0050952"/>
-        <oboInOwl:hasExactSynonym>electroception sense</oboInOwl:hasExactSynonym>
-        <oboInOwl:hasExactSynonym>electroceptive sense</oboInOwl:hasExactSynonym>
-        <rdfs:label>electroception</rdfs:label>
-    </owl:Class>
-    
-
-
     <!-- http://purl.obolibrary.org/obo/GO_0050962 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0050962">
@@ -97094,93 +97972,6 @@ For example, A and B may be gene products and binding of B by A positively regul
     
 
 
-    <!-- http://purl.obolibrary.org/obo/GO_0050963 -->
-
-    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0050963">
-        <owl:equivalentClass>
-            <owl:Class>
-                <owl:intersectionOf rdf:parseType="Collection">
-                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/GO_0050981"/>
-                    <owl:Restriction>
-                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
-                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0007600"/>
-                    </owl:Restriction>
-                </owl:intersectionOf>
-            </owl:Class>
-        </owl:equivalentClass>
-        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0050906"/>
-        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0050981"/>
-        <rdfs:subClassOf>
-            <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
-                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0050952"/>
-            </owl:Restriction>
-        </rdfs:subClassOf>
-        <oboInOwl:hasExactSynonym>sensory detection of electrical stimulus</oboInOwl:hasExactSynonym>
-        <oboInOwl:hasExactSynonym>sensory detection of electrical stimulus during sensory perception</oboInOwl:hasExactSynonym>
-        <oboInOwl:hasExactSynonym>sensory perception, sensory detection of electrical stimulus</oboInOwl:hasExactSynonym>
-        <oboInOwl:hasExactSynonym>sensory perception, sensory transduction of electrical stimulus</oboInOwl:hasExactSynonym>
-        <oboInOwl:hasExactSynonym>sensory transduction of electrical stimulus</oboInOwl:hasExactSynonym>
-        <oboInOwl:hasExactSynonym>sensory transduction of electrical stimulus during sensory perception</oboInOwl:hasExactSynonym>
-        <rdfs:label>detection of electrical stimulus involved in sensory perception</rdfs:label>
-    </owl:Class>
-    
-
-
-    <!-- http://purl.obolibrary.org/obo/GO_0050964 -->
-
-    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0050964">
-        <owl:equivalentClass>
-            <owl:Class>
-                <owl:intersectionOf rdf:parseType="Collection">
-                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/GO_0050981"/>
-                    <owl:Restriction>
-                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
-                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0050956"/>
-                    </owl:Restriction>
-                </owl:intersectionOf>
-            </owl:Class>
-        </owl:equivalentClass>
-        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0050963"/>
-        <rdfs:subClassOf>
-            <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
-                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0050956"/>
-            </owl:Restriction>
-        </rdfs:subClassOf>
-        <oboInOwl:hasExactSynonym>electroception, detection of electrical stimulus</oboInOwl:hasExactSynonym>
-        <oboInOwl:hasExactSynonym>electroception, sensory detection of electrical stimulus</oboInOwl:hasExactSynonym>
-        <oboInOwl:hasExactSynonym>electroception, sensory transduction</oboInOwl:hasExactSynonym>
-        <oboInOwl:hasExactSynonym>electroception, sensory transduction of electrical stimulus</oboInOwl:hasExactSynonym>
-        <rdfs:label>detection of electrical stimulus involved in electroception</rdfs:label>
-    </owl:Class>
-    
-
-
-    <!-- http://purl.obolibrary.org/obo/GO_0050967 -->
-
-    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0050967">
-        <owl:equivalentClass>
-            <owl:Class>
-                <owl:intersectionOf rdf:parseType="Collection">
-                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/GO_0050981"/>
-                    <owl:Restriction>
-                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
-                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0019233"/>
-                    </owl:Restriction>
-                </owl:intersectionOf>
-            </owl:Class>
-        </owl:equivalentClass>
-        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0050963"/>
-        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0062149"/>
-        <oboInOwl:hasExactSynonym>perception of pain, detection of electrical stimulus</oboInOwl:hasExactSynonym>
-        <oboInOwl:hasExactSynonym>perception of pain, sensory detection of electrical stimulus</oboInOwl:hasExactSynonym>
-        <oboInOwl:hasExactSynonym>perception of pain, sensory transduction of electrical stimulus</oboInOwl:hasExactSynonym>
-        <rdfs:label>detection of electrical stimulus involved in sensory perception of pain</rdfs:label>
-    </owl:Class>
-    
-
-
     <!-- http://purl.obolibrary.org/obo/GO_0050968 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0050968">
@@ -97220,16 +98011,6 @@ For example, A and B may be gene products and binding of B by A positively regul
     
 
 
-    <!-- http://purl.obolibrary.org/obo/GO_0050981 -->
-
-    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0050981">
-        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0009582"/>
-        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0051602"/>
-        <rdfs:label>detection of electrical stimulus</rdfs:label>
-    </owl:Class>
-    
-
-
     <!-- http://purl.obolibrary.org/obo/GO_0050994 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0050994">
@@ -99660,15 +100441,6 @@ For example, A and B may be gene products and binding of B by A positively regul
     
 
 
-    <!-- http://purl.obolibrary.org/obo/GO_0051602 -->
-
-    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0051602">
-        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0009628"/>
-        <rdfs:label>response to electrical stimulus</rdfs:label>
-    </owl:Class>
-    
-
-
     <!-- http://purl.obolibrary.org/obo/GO_0051606 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0051606">
@@ -124993,6 +125765,7 @@ For example, A and B may be gene products and binding of B by A positively regul
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/COB_0000013"/>
             </owl:Restriction>
         </rdfs:subClassOf>
+        <owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000001"/>
         <obo:IAO_0000115>A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex.</obo:IAO_0000115>
         <oboInOwl:hasExactSynonym>cellular anatomical entity</oboInOwl:hasExactSynonym>
         <rdfs:label>cellular anatomical entity</rdfs:label>
@@ -125107,6 +125880,40 @@ For example, A and B may be gene products and binding of B by A positively regul
     
 
 
+    <!-- http://purl.obolibrary.org/obo/GO_0120029 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0120029">
+        <owl:equivalentClass>
+            <owl:Class>
+                <owl:intersectionOf rdf:parseType="Collection">
+                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/GO_0006810"/>
+                    <owl:Restriction>
+                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002338"/>
+                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0005829"/>
+                    </owl:Restriction>
+                    <owl:Restriction>
+                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002339"/>
+                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0005576"/>
+                    </owl:Restriction>
+                    <owl:Restriction>
+                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002342"/>
+                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0005886"/>
+                    </owl:Restriction>
+                    <owl:Restriction>
+                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0004009"/>
+                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_15378"/>
+                    </owl:Restriction>
+                </owl:intersectionOf>
+            </owl:Class>
+        </owl:equivalentClass>
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0140115"/>
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_1902600"/>
+        <oboInOwl:hasExactSynonym>hydrogen ion export across plasma membrane</oboInOwl:hasExactSynonym>
+        <rdfs:label>proton export across plasma membrane</rdfs:label>
+    </owl:Class>
+    
+
+
     <!-- http://purl.obolibrary.org/obo/GO_0120031 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0120031">
@@ -133867,6 +134674,35 @@ For example, A and B may be gene products and binding of B by A positively regul
     
 
 
+    <!-- http://purl.obolibrary.org/obo/GO_1902600 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_1902600">
+        <owl:equivalentClass>
+            <owl:Class>
+                <owl:intersectionOf rdf:parseType="Collection">
+                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/GO_0055085"/>
+                    <owl:Restriction>
+                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0004009"/>
+                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_15378"/>
+                    </owl:Restriction>
+                </owl:intersectionOf>
+            </owl:Class>
+        </owl:equivalentClass>
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0098655"/>
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0098662"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0004009"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_15378"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
+        <oboInOwl:hasExactSynonym>hydrogen ion transmembrane transport</oboInOwl:hasExactSynonym>
+        <oboInOwl:hasExactSynonym>hydrogen transmembrane transport</oboInOwl:hasExactSynonym>
+        <rdfs:label>proton transmembrane transport</rdfs:label>
+    </owl:Class>
+    
+
+
     <!-- http://purl.obolibrary.org/obo/GO_1902679 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_1902679">
@@ -152650,6 +153486,7 @@ interpreted by or directly executed by a processing unit.</obo:IAO_0000115>
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/IAO_0000027">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000030"/>
         <obo:IAO_0000115 xml:lang="en">An information content entity that is intended to be a truthful statement about something (modulo, e.g., measurement precision or other systematic errors) and is constructed/acquired by a method which reliably tends to produce (approximately) truthful statements.</obo:IAO_0000115>
+        <rdfs:label xml:lang="en">data entity</rdfs:label>
         <rdfs:label xml:lang="en">data item</rdfs:label>
     </owl:Class>
     
@@ -153192,6 +154029,24 @@ clustering algorithm.</obo:IAO_0000115>
     
 
 
+    <!-- http://purl.obolibrary.org/obo/NCBITaxon_1224 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_1224">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_3379134"/>
+        <rdfs:label>Pseudomonadota</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/NCBITaxon_1236 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_1236">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_1224"/>
+        <rdfs:label>Gammaproteobacteria</rdfs:label>
+    </owl:Class>
+    
+
+
     <!-- http://purl.obolibrary.org/obo/NCBITaxon_124129 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_124129">
@@ -153242,7 +154097,9 @@ clustering algorithm.</obo:IAO_0000115>
     <!-- http://purl.obolibrary.org/obo/NCBITaxon_131567 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_131567">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/COB_0000022"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_1"/>
+        <rdfs:label>cellular organism</rdfs:label>
         <rdfs:label>cellular organisms</rdfs:label>
     </owl:Class>
     
@@ -153577,9 +154434,7 @@ clustering algorithm.</obo:IAO_0000115>
     <!-- http://purl.obolibrary.org/obo/NCBITaxon_2759 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_2759">
-        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/COB_0000022"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_131567"/>
-        <obo:IAO_0000118>eucaryotes</obo:IAO_0000118>
         <obo:IAO_0000118>eukaryotes</obo:IAO_0000118>
         <rdfs:label>Eukaryota</rdfs:label>
     </owl:Class>
@@ -153806,6 +154661,7 @@ clustering algorithm.</obo:IAO_0000115>
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_33208">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_33154"/>
         <owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_4751"/>
+        <obo:IAO_0000118>animals</obo:IAO_0000118>
         <obo:IAO_0000118>metazoans</obo:IAO_0000118>
         <obo:IAO_0000118>multicellular animals</obo:IAO_0000118>
         <rdfs:label>Metazoa</rdfs:label>
@@ -153905,6 +154761,15 @@ clustering algorithm.</obo:IAO_0000115>
     
 
 
+    <!-- http://purl.obolibrary.org/obo/NCBITaxon_3379134 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_3379134">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_2"/>
+        <rdfs:label>Pseudomonadati</rdfs:label>
+    </owl:Class>
+    
+
+
     <!-- http://purl.obolibrary.org/obo/NCBITaxon_3398 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_3398">
@@ -154222,6 +155087,15 @@ clustering algorithm.</obo:IAO_0000115>
     
 
 
+    <!-- http://purl.obolibrary.org/obo/NCBITaxon_543 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_543">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_91347"/>
+        <rdfs:label>Enterobacteriaceae</rdfs:label>
+    </owl:Class>
+    
+
+
     <!-- http://purl.obolibrary.org/obo/NCBITaxon_554915 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_554915">
@@ -154249,6 +155123,24 @@ clustering algorithm.</obo:IAO_0000115>
     
 
 
+    <!-- http://purl.obolibrary.org/obo/NCBITaxon_561 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_561">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_543"/>
+        <rdfs:label>Escherichia</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/NCBITaxon_562 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_562">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_561"/>
+        <rdfs:label>Escherichia coli</rdfs:label>
+    </owl:Class>
+    
+
+
     <!-- http://purl.obolibrary.org/obo/NCBITaxon_5782 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_5782">
@@ -154387,6 +155279,15 @@ clustering algorithm.</obo:IAO_0000115>
     
 
 
+    <!-- http://purl.obolibrary.org/obo/NCBITaxon_637912 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_637912">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_562"/>
+        <rdfs:label>Escherichia coli OP50</rdfs:label>
+    </owl:Class>
+    
+
+
     <!-- http://purl.obolibrary.org/obo/NCBITaxon_6656 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_6656">
@@ -154869,6 +155770,15 @@ clustering algorithm.</obo:IAO_0000115>
     
 
 
+    <!-- http://purl.obolibrary.org/obo/NCBITaxon_91347 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_91347">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_1236"/>
+        <rdfs:label>Enterobacterales</rdfs:label>
+    </owl:Class>
+    
+
+
     <!-- http://purl.obolibrary.org/obo/NCBITaxon_9254 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_9254">
@@ -155045,6 +155955,15 @@ clustering algorithm.</obo:IAO_0000115>
     
 
 
+    <!-- http://purl.obolibrary.org/obo/NCIT_C16203 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCIT_C16203">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCIT_C43431"/>
+        <rdfs:label>Clinical or Research Activity</rdfs:label>
+    </owl:Class>
+    
+
+
     <!-- http://purl.obolibrary.org/obo/NCIT_C16847 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCIT_C16847">
@@ -155054,6 +155973,25 @@ clustering algorithm.</obo:IAO_0000115>
     
 
 
+    <!-- http://purl.obolibrary.org/obo/NCIT_C16853 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCIT_C16853">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCIT_C17369"/>
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCIT_C74957"/>
+        <rdfs:label>Microscopy</rdfs:label>
+    </owl:Class>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/NCIT_C16856 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCIT_C16856">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCIT_C17995"/>
+        <rdfs:label>Fluorescence Microscopy</rdfs:label>
+    </owl:Class>
+    
+
+
     <!-- http://purl.obolibrary.org/obo/NCIT_C17187 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCIT_C17187">
@@ -155072,6 +156010,15 @@ clustering algorithm.</obo:IAO_0000115>
     
 
 
+    <!-- http://purl.obolibrary.org/obo/NCIT_C17369 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCIT_C17369">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCIT_C25218"/>
+        <rdfs:label>Imaging Procedure</rdfs:label>
+    </owl:Class>
+    
+
+
     <!-- http://purl.obolibrary.org/obo/NCIT_C179817 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCIT_C179817">
@@ -155082,6 +156029,15 @@ clustering algorithm.</obo:IAO_0000115>
     
 
 
+    <!-- http://purl.obolibrary.org/obo/NCIT_C17995 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCIT_C17995">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCIT_C16853"/>
+        <rdfs:label>Light Microscopy</rdfs:label>
+    </owl:Class>
+    
+
+
     <!-- http://purl.obolibrary.org/obo/NCIT_C18141 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCIT_C18141">
@@ -155210,6 +156166,15 @@ clustering algorithm.</obo:IAO_0000115>
     
 
 
+    <!-- http://purl.obolibrary.org/obo/NCIT_C25218 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCIT_C25218">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCIT_C16203"/>
+        <rdfs:label>Clinical Intervention or Procedure</rdfs:label>
+    </owl:Class>
+    
+
+
     <!-- http://purl.obolibrary.org/obo/NCIT_C25284 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCIT_C25284">
@@ -155228,6 +156193,15 @@ clustering algorithm.</obo:IAO_0000115>
     
 
 
+    <!-- http://purl.obolibrary.org/obo/NCIT_C25294 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCIT_C25294">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCIT_C25218"/>
+        <rdfs:label>Laboratory Procedure</rdfs:label>
+    </owl:Class>
+    
+
+
     <!-- http://purl.obolibrary.org/obo/NCIT_C25335 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCIT_C25335">
@@ -155435,6 +156409,15 @@ clustering algorithm.</obo:IAO_0000115>
     
 
 
+    <!-- http://purl.obolibrary.org/obo/NCIT_C74957 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCIT_C74957">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCIT_C25294"/>
+        <rdfs:label>Mixed Category Laboratory Procedure</rdfs:label>
+    </owl:Class>
+    
+
+
     <!-- http://purl.obolibrary.org/obo/NCIT_C85776 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCIT_C85776">
@@ -160575,13 +161558,22 @@ class labels for these objects. The resulting predictor can be used to attach cl
     <!-- http://purl.obolibrary.org/obo/UBERON_0000000 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0000000">
-        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
         <owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/UBERON_0001062"/>
         <rdfs:label>processual entity</rdfs:label>
     </owl:Class>
     
 
 
+    <!-- http://purl.obolibrary.org/obo/UBERON_0000001 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0000001">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000465"/>
+        <owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000468"/>
+        <rdfs:label>gross anatomical part</rdfs:label>
+    </owl:Class>
+    
+
+
     <!-- http://purl.obolibrary.org/obo/UBERON_0000005 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0000005">
@@ -161367,6 +162359,7 @@ class labels for these objects. The resulting predictor can be used to attach cl
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000071"/>
             </owl:Restriction>
         </rdfs:subClassOf>
+        <obo:IAO_0000115>Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism&apos;s own genome.</obo:IAO_0000115>
         <oboInOwl:hasExactSynonym>biological structure</oboInOwl:hasExactSynonym>
         <rdfs:label>anatomical structure</rdfs:label>
     </owl:Class>
@@ -161976,6 +162969,7 @@ class labels for these objects. The resulting predictor can be used to attach cl
     <!-- http://purl.obolibrary.org/obo/UBERON_0000104 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0000104">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000000"/>
         <rdfs:subClassOf>
             <owl:Restriction>
@@ -161995,6 +162989,7 @@ class labels for these objects. The resulting predictor can be used to attach cl
     <!-- http://purl.obolibrary.org/obo/UBERON_0000105 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0000105">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000000"/>
         <rdfs:subClassOf>
             <owl:Restriction>
@@ -162682,12 +163677,6 @@ class labels for these objects. The resulting predictor can be used to attach cl
             </owl:Class>
         </owl:equivalentClass>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/UBERON_0004921"/>
-        <rdfs:subClassOf>
-            <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
-                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0001155"/>
-            </owl:Restriction>
-        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/uberon/core#subdivision_of"/>
@@ -163970,7 +164959,7 @@ class labels for these objects. The resulting predictor can be used to attach cl
     <!-- http://purl.obolibrary.org/obo/UBERON_0000463 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0000463">
-        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000465"/>
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000001"/>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
@@ -163983,6 +164972,7 @@ class labels for these objects. The resulting predictor can be used to attach cl
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/PATO_0002198"/>
             </owl:Restriction>
         </rdfs:subClassOf>
+        <owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000468"/>
         <rdfs:label>organism substance</rdfs:label>
     </owl:Class>
     
@@ -164127,6 +165117,7 @@ class labels for these objects. The resulting predictor can be used to attach cl
     <!-- http://purl.obolibrary.org/obo/UBERON_0000476 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0000476">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000001"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000061"/>
         <rdfs:label>acellular anatomical structure</rdfs:label>
     </owl:Class>
@@ -193316,12 +194307,6 @@ class labels for these objects. The resulting predictor can be used to attach cl
             </owl:Class>
         </owl:equivalentClass>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/UBERON_0013522"/>
-        <rdfs:subClassOf>
-            <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
-                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0001555"/>
-            </owl:Restriction>
-        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/uberon/core#subdivision_of"/>
@@ -195697,7 +196682,7 @@ class labels for these objects. The resulting predictor can be used to attach cl
     <!-- http://purl.obolibrary.org/obo/UBERON_0005423 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0005423">
-        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000465"/>
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000001"/>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002215"/>
@@ -198140,12 +199125,6 @@ class labels for these objects. The resulting predictor can be used to attach cl
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0002090"/>
             </owl:Restriction>
         </rdfs:subClassOf>
-        <rdfs:subClassOf>
-            <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
-                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0006071"/>
-            </owl:Restriction>
-        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/uberon/core#subdivision_of"/>
@@ -198172,12 +199151,6 @@ class labels for these objects. The resulting predictor can be used to attach cl
             </owl:Class>
         </owl:equivalentClass>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000075"/>
-        <rdfs:subClassOf>
-            <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
-                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0001130"/>
-            </owl:Restriction>
-        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
@@ -205617,12 +206590,6 @@ class labels for these objects. The resulting predictor can be used to attach cl
             </owl:Class>
         </owl:equivalentClass>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/UBERON_0006077"/>
-        <rdfs:subClassOf>
-            <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
-                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0002100"/>
-            </owl:Restriction>
-        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/uberon/core#subdivision_of"/>
@@ -209718,34 +210685,6 @@ class labels for these objects. The resulting predictor can be used to attach cl
     
 
 
-    <!-- http://purl.obolibrary.org/obo/UBERON_0010521 -->
-
-    <owl:Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0010521">
-        <owl:equivalentClass>
-            <owl:Class>
-                <owl:intersectionOf rdf:parseType="Collection">
-                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/UBERON_0000062"/>
-                    <owl:Restriction>
-                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002215"/>
-                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0050964"/>
-                    </owl:Restriction>
-                </owl:intersectionOf>
-            </owl:Class>
-        </owl:equivalentClass>
-        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000020"/>
-        <rdfs:subClassOf>
-            <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002215"/>
-                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0050964"/>
-            </owl:Restriction>
-        </rdfs:subClassOf>
-        <oboInOwl:hasExactSynonym>electric sense organ</oboInOwl:hasExactSynonym>
-        <oboInOwl:hasExactSynonym>electroreception organ</oboInOwl:hasExactSynonym>
-        <rdfs:label>electroreceptor organ</rdfs:label>
-    </owl:Class>
-    
-
-
     <!-- http://purl.obolibrary.org/obo/UBERON_0010522 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0010522">
@@ -214074,12 +215013,6 @@ class labels for these objects. The resulting predictor can be used to attach cl
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0013522">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000064"/>
-        <rdfs:subClassOf>
-            <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
-                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000025"/>
-            </owl:Restriction>
-        </rdfs:subClassOf>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
@@ -220902,7 +221835,7 @@ class labels for these objects. The resulting predictor can be used to attach cl
     <!-- http://purl.obolibrary.org/obo/UBERON_0036215 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0036215">
-        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000465"/>
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000001"/>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002007"/>
@@ -223410,6 +224343,32 @@ class labels for these objects. The resulting predictor can be used to attach cl
     
 
 
+    <!-- http://purl.obolibrary.org/obo/UBERON_8850001 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/UBERON_8850001">
+        <owl:equivalentClass>
+            <owl:Class>
+                <owl:intersectionOf rdf:parseType="Collection">
+                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/UBERON_0000483"/>
+                    <owl:Restriction>
+                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
+                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_8410050"/>
+                    </owl:Restriction>
+                </owl:intersectionOf>
+            </owl:Class>
+        </owl:equivalentClass>
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/UBERON_0001278"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_8410050"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
+        <rdfs:label>epithelium of anorectum</rdfs:label>
+    </owl:Class>
+    
+
+
     <!-- http://purl.obolibrary.org/obo/UO_0000001 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/UO_0000001">
@@ -223500,6 +224459,18 @@ class labels for these objects. The resulting predictor can be used to attach cl
     
 
 
+    <!-- http://purl.obolibrary.org/obo/format_1929 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/format_1929"/>
+    
+
+
+    <!-- http://purl.obolibrary.org/obo/NCBITaxon:637912 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon:637912"/>
+    
+
+
     <!-- http://www.geneontology.org/formats/oboInOwl#ObsoleteClass -->
 
     <owl:Class rdf:about="http://www.geneontology.org/formats/oboInOwl#ObsoleteClass">
diff --git a/src/ontology/empty-edit.owl b/src/ontology/empty-edit.owl
index eabd0a2..cdd964c 100644
--- a/src/ontology/empty-edit.owl
+++ b/src/ontology/empty-edit.owl
@@ -255,7 +255,38 @@ Declaration(Class(obo:EMPTY_0000227))
 Declaration(Class(obo:EMPTY_0000228))
 Declaration(Class(obo:EMPTY_0000229))
 Declaration(Class(obo:EMPTY_0000230))
+Declaration(Class(obo:EMPTY_0000231))
+Declaration(Class(obo:EMPTY_0000232))
+Declaration(Class(obo:EMPTY_0000233))
+Declaration(Class(obo:EMPTY_0000234))
+Declaration(Class(obo:EMPTY_0000235))
+Declaration(Class(obo:EMPTY_0000236))
+Declaration(Class(obo:EMPTY_0000237))
+Declaration(Class(obo:EMPTY_0000238))
+Declaration(Class(obo:EMPTY_0000239))
+Declaration(Class(obo:EMPTY_0000240))
+Declaration(Class(obo:EMPTY_0000241))
+Declaration(Class(obo:EMPTY_0000242))
+Declaration(Class(obo:EMPTY_0000243))
+Declaration(Class(obo:EMPTY_0000244))
+Declaration(Class(obo:EMPTY_0000245))
+Declaration(Class(obo:EMPTY_0000246))
+Declaration(Class(obo:EMPTY_0000247))
+Declaration(Class(obo:EMPTY_0000248))
+Declaration(Class(obo:EMPTY_0000249))
+Declaration(Class(obo:EMPTY_0000250))
+Declaration(Class(obo:EMPTY_0000251))
+Declaration(Class(obo:EMPTY_0000252))
+Declaration(Class(obo:EMPTY_0000253))
+Declaration(Class(obo:EMPTY_0000254))
+Declaration(Class(obo:EMPTY_0000255))
+Declaration(Class(obo:EMPTY_0000256))
+Declaration(Class(obo:EMPTY_0000257))
+Declaration(Class(obo:EMPTY_0000258))
+Declaration(Class(obo:format_1929))
+Declaration(Class(obo:NCBITaxon:637912))
 Declaration(Class(obo:NCIT_C14240))
+Declaration(Class(obo:NCIT_C16856))
 Declaration(Class(obo:NCIT_C172272))
 Declaration(Class(obo:NCIT_C179817))
 Declaration(Class(obo:NCIT_C201530))
@@ -343,298 +374,298 @@ SubClassOf(obo:EMPTY_0000005 obo:EMPTY_0000002)
 
 # Class: obo:EMPTY_0000006 (elevated plus maze: open arm (north) - entries)
 
-AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000006 "In the Elevated Plus Maze task, this counts the number of times the animal's body (typically defined by its center point or a significant portion) fully enters the user-defined zone designated as 'Open Arm (North)'. The 'Open Arm (North)' is one of the two open arms, distinguished by its assigned 'north' orientation or designation in the experimental setup. Unit of measure: count")
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000006 "In the Elevated Plus Maze task, this counts the number of times the animal's body (typically defined by its center point or a significant portion) fully enters the user-defined zone designated as 'Open Arm (North)'. The 'Open Arm (North)' is one of the two open arms, distinguished by its assigned 'north' orientation or designation in the experimental setup. Unit: count")
 AnnotationAssertion(rdfs:label obo:EMPTY_0000006 "elevated plus maze: open arm (north) - entries"@en)
 SubClassOf(obo:EMPTY_0000006 obo:EMPTY_0000003)
 
 # Class: obo:EMPTY_0000007 (elevated plus maze: open arm (south) - entries)
 
-AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000007 "In the Elevated Plus Maze task, this counts the number of times the animal's body (typically defined by its center point or a significant portion) fully enters the user-defined zone designated as 'Open Arm (South)'. The 'Open Arm (South)' is one of the two open arms, distinguished by its assigned 'south' orientation or designation in the experimental setup. Unit of measure: count")
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000007 "In the Elevated Plus Maze task, this counts the number of times the animal's body (typically defined by its center point or a significant portion) fully enters the user-defined zone designated as 'Open Arm (South)'. The 'Open Arm (South)' is one of the two open arms, distinguished by its assigned 'south' orientation or designation in the experimental setup. Unit: count")
 AnnotationAssertion(rdfs:label obo:EMPTY_0000007 "elevated plus maze: open arm (south) - entries"@en)
 SubClassOf(obo:EMPTY_0000007 obo:EMPTY_0000003)
 
 # Class: obo:EMPTY_0000008 (elevated plus maze: open arm total entries)
 
-AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000008 "In the Elevated Plus Maze task, this represents the total number of times the animal's body (typically defined by its center point or a significant portion) fully enters the designated open arm zones (e.g., 'Open Arm (North)' and 'Open Arm (South)'). It is a common measure of exploration and anxiety. Unit of measure: count")
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000008 "In the Elevated Plus Maze task, this represents the total number of times the animal's body (typically defined by its center point or a significant portion) fully enters the designated open arm zones (e.g., 'Open Arm (North)' and 'Open Arm (South)'). It is a common measure of exploration and anxiety. Unit: count")
 AnnotationAssertion(rdfs:label obo:EMPTY_0000008 "elevated plus maze: open arm total entries"@en)
 SubClassOf(obo:EMPTY_0000008 obo:EMPTY_0000003)
 
 # Class: obo:EMPTY_0000009 (elevated plus maze: open arm (north) - head entries)
 
-AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000009 "In the Elevated Plus Maze task, this counts the number of times the animal's head (specifically tracked by the software) enters the user-defined 'Open Arm (North)' zone, irrespective of full body entry. This can indicate risk assessment or tentative exploration of the arm designated as 'north'. Unit of measure: count")
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000009 "In the Elevated Plus Maze task, this counts the number of times the animal's head (specifically tracked by the software) enters the user-defined 'Open Arm (North)' zone, irrespective of full body entry. This can indicate risk assessment or tentative exploration of the arm designated as 'north'. Unit: count")
 AnnotationAssertion(rdfs:label obo:EMPTY_0000009 "elevated plus maze: open arm (north) - head entries"@en)
 SubClassOf(obo:EMPTY_0000009 obo:EMPTY_0000003)
 
 # Class: obo:EMPTY_0000010 (elevated plus maze: open arm (south) - head entries)
 
-AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000010 "In the Elevated Plus Maze task, this counts the number of times the animal's head (specifically tracked by the software) enters the user-defined 'Open Arm (South)' zone, irrespective of full body entry, often reflecting cautious exploration of the open arm designated as 'south'. Unit of measure: count")
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000010 "In the Elevated Plus Maze task, this counts the number of times the animal's head (specifically tracked by the software) enters the user-defined 'Open Arm (South)' zone, irrespective of full body entry, often reflecting cautious exploration of the open arm designated as 'south'. Unit: count")
 AnnotationAssertion(rdfs:label obo:EMPTY_0000010 "elevated plus maze: open arm (south) - head entries"@en)
 SubClassOf(obo:EMPTY_0000010 obo:EMPTY_0000003)
 
 # Class: obo:EMPTY_0000011 (elevated plus maze: open arm total head entries)
 
-AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000011 "In the Elevated Plus Maze task, this is the total number of times the animal's head (specifically tracked by the software) enters any of the designated open arm zones (e.g., 'Open Arm (North)' and 'Open Arm (South)'), considered an indicator of risk-assessment behavior. Unit of measure: count")
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000011 "In the Elevated Plus Maze task, this is the total number of times the animal's head (specifically tracked by the software) enters any of the designated open arm zones (e.g., 'Open Arm (North)' and 'Open Arm (South)'), considered an indicator of risk-assessment behavior. Unit: count")
 AnnotationAssertion(rdfs:label obo:EMPTY_0000011 "elevated plus maze: open arm total head entries"@en)
 SubClassOf(obo:EMPTY_0000011 obo:EMPTY_0000003)
 
 # Class: obo:EMPTY_0000012 (elevated plus maze: open arm (north) - time)
 
-AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000012 "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Open Arm (North)' zone. Unit of measure: seconds")
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000012 "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Open Arm (North)' zone. Unit: seconds")
 AnnotationAssertion(rdfs:label obo:EMPTY_0000012 "elevated plus maze: open arm (north) - time"@en)
 SubClassOf(obo:EMPTY_0000012 obo:EMPTY_0000003)
 SubClassOf(obo:EMPTY_0000012 obo:EMPTY_0000090)
 
 # Class: obo:EMPTY_0000013 (elevated plus maze: open arm (south) - time)
 
-AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000013 "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Open Arm (South)' zone. Unit of measure: seconds")
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000013 "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Open Arm (South)' zone. Unit: seconds")
 AnnotationAssertion(rdfs:label obo:EMPTY_0000013 "elevated plus maze: open arm (south) - time"@en)
 SubClassOf(obo:EMPTY_0000013 obo:EMPTY_0000003)
 SubClassOf(obo:EMPTY_0000013 obo:EMPTY_0000090)
 
 # Class: obo:EMPTY_0000014 (elevated plus maze: open arm total time)
 
-AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000014 "In the Elevated Plus Maze task, this is the cumulative total duration the animal's body spends within any of the designated open arm zones (e.g., 'Open Arm (North)' and 'Open Arm (South)'). Less time is generally indicative of higher anxiety. Unit of measure: seconds")
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000014 "In the Elevated Plus Maze task, this is the cumulative total duration the animal's body spends within any of the designated open arm zones (e.g., 'Open Arm (North)' and 'Open Arm (South)'). Less time is generally indicative of higher anxiety. Unit: seconds")
 AnnotationAssertion(rdfs:label obo:EMPTY_0000014 "elevated plus maze: open arm total time"@en)
 SubClassOf(obo:EMPTY_0000014 obo:EMPTY_0000003)
 SubClassOf(obo:EMPTY_0000014 obo:EMPTY_0000090)
 
 # Class: obo:EMPTY_0000015 (elevated plus maze: open arm total - percent time during test duration)
 
-AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000015 "In the Elevated Plus Maze task, this represents the percentage of the total test duration that the animal spends in any of the designated open arm zones (e.g., 'Open Arm (North)' and 'Open Arm (South)'). Unit of measure: %")
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000015 "In the Elevated Plus Maze task, this represents the percentage of the total test duration that the animal spends in any of the designated open arm zones (e.g., 'Open Arm (North)' and 'Open Arm (South)'). Unit: %")
 AnnotationAssertion(rdfs:label obo:EMPTY_0000015 "elevated plus maze: open arm total - percent time during test duration"@en)
 SubClassOf(obo:EMPTY_0000015 obo:EMPTY_0000003)
 
 # Class: obo:EMPTY_0000016 (elevated plus maze: open arm (north) - latency to first entry)
 
-AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000016 "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Open Arm (North)' zone. Unit of measure: seconds")
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000016 "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Open Arm (North)' zone. Unit: seconds")
 AnnotationAssertion(rdfs:label obo:EMPTY_0000016 "elevated plus maze: open arm (north) - latency to first entry"@en)
 SubClassOf(obo:EMPTY_0000016 obo:EMPTY_0000003)
 SubClassOf(obo:EMPTY_0000016 obo:EMPTY_0000091)
 
 # Class: obo:EMPTY_0000017 (elevated plus maze: open arm (south) - latency to first entry)
 
-AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000017 "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Open Arm (South)' zone. Unit of measure: seconds")
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000017 "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Open Arm (South)' zone. Unit: seconds")
 AnnotationAssertion(rdfs:label obo:EMPTY_0000017 "elevated plus maze: open arm (south) - latency to first entry"@en)
 SubClassOf(obo:EMPTY_0000017 obo:EMPTY_0000003)
 SubClassOf(obo:EMPTY_0000017 obo:EMPTY_0000091)
 
 # Class: obo:EMPTY_0000018 (elevated plus maze: open arm total latency to first entry)
 
-AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000018 "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into any of the designated open arm zones (e.g., 'Open Arm (North)' or 'Open Arm (South)'). Longer latencies often suggest higher anxiety. Unit of measure: seconds")
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000018 "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into any of the designated open arm zones (e.g., 'Open Arm (North)' or 'Open Arm (South)'). Longer latencies often suggest higher anxiety. Unit: seconds")
 AnnotationAssertion(rdfs:label obo:EMPTY_0000018 "elevated plus maze: open arm total latency to first entry"@en)
 SubClassOf(obo:EMPTY_0000018 obo:EMPTY_0000003)
 SubClassOf(obo:EMPTY_0000018 obo:EMPTY_0000091)
 
 # Class: obo:EMPTY_0000019 (elevated plus maze: open arm (north) - time moving towards)
 
-AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000019 "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Open Arm (North)' zone, as detected by the tracking software. Unit of measure: seconds")
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000019 "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Open Arm (North)' zone, as detected by the tracking software. Unit: seconds")
 AnnotationAssertion(rdfs:label obo:EMPTY_0000019 "elevated plus maze: open arm (north) - time moving towards"@en)
 SubClassOf(obo:EMPTY_0000019 obo:EMPTY_0000003)
 SubClassOf(obo:EMPTY_0000019 obo:EMPTY_0000090)
 
 # Class: obo:EMPTY_0000020 (elevated plus maze: open arm (south) - time moving towards)
 
-AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000020 "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Open Arm (South)' zone, as detected by the tracking software. Unit of measure: seconds")
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000020 "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Open Arm (South)' zone, as detected by the tracking software. Unit: seconds")
 AnnotationAssertion(rdfs:label obo:EMPTY_0000020 "elevated plus maze: open arm (south) - time moving towards"@en)
 SubClassOf(obo:EMPTY_0000020 obo:EMPTY_0000003)
 SubClassOf(obo:EMPTY_0000020 obo:EMPTY_0000090)
 
 # Class: obo:EMPTY_0000021 (elevated plus maze: open arm total time moving towards)
 
-AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000021 "In the Elevated Plus Maze task, this is the cumulative duration the animal spends actively moving towards any of the designated open arm zones (e.g., 'Open Arm (North)' or 'Open Arm (South)'), reflecting approach motivation. Unit of measure: seconds")
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000021 "In the Elevated Plus Maze task, this is the cumulative duration the animal spends actively moving towards any of the designated open arm zones (e.g., 'Open Arm (North)' or 'Open Arm (South)'), reflecting approach motivation. Unit: seconds")
 AnnotationAssertion(rdfs:label obo:EMPTY_0000021 "elevated plus maze: open arm total time moving towards"@en)
 SubClassOf(obo:EMPTY_0000021 obo:EMPTY_0000003)
 SubClassOf(obo:EMPTY_0000021 obo:EMPTY_0000090)
 
 # Class: obo:EMPTY_0000022 (elevated plus maze: open arm (north) - time freezing)
 
-AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000022 "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior (a state of immobility except for respiratory movements) while within the user-defined 'Open Arm (North)' zone. Freezing is a common fear response. Unit of measure: seconds")
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000022 "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior (a state of immobility except for respiratory movements) while within the user-defined 'Open Arm (North)' zone. Freezing is a common fear response. Unit: seconds")
 AnnotationAssertion(rdfs:label obo:EMPTY_0000022 "elevated plus maze: open arm (north) - time freezing"@en)
 SubClassOf(obo:EMPTY_0000022 obo:EMPTY_0000003)
 SubClassOf(obo:EMPTY_0000022 obo:EMPTY_0000090)
 
 # Class: obo:EMPTY_0000023 (elevated plus maze: open arm (south) - time freezing)
 
-AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000023 "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined 'Open Arm (South)' zone. Unit of measure: seconds")
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000023 "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined 'Open Arm (South)' zone. Unit: seconds")
 AnnotationAssertion(rdfs:label obo:EMPTY_0000023 "elevated plus maze: open arm (south) - time freezing"@en)
 SubClassOf(obo:EMPTY_0000023 obo:EMPTY_0000003)
 SubClassOf(obo:EMPTY_0000023 obo:EMPTY_0000090)
 
 # Class: obo:EMPTY_0000024 (elevated plus maze: open arm total time freezing)
 
-AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000024 "In the Elevated Plus Maze task, this is the cumulative duration the animal exhibits freezing behavior while within any of the designated open arm zones (e.g., 'Open Arm (North)' or 'Open Arm (South)'), indicating fear or anxiety. Unit of measure: seconds")
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000024 "In the Elevated Plus Maze task, this is the cumulative duration the animal exhibits freezing behavior while within any of the designated open arm zones (e.g., 'Open Arm (North)' or 'Open Arm (South)'), indicating fear or anxiety. Unit: seconds")
 AnnotationAssertion(rdfs:label obo:EMPTY_0000024 "elevated plus maze: open arm total time freezing"@en)
 SubClassOf(obo:EMPTY_0000024 obo:EMPTY_0000003)
 SubClassOf(obo:EMPTY_0000024 obo:EMPTY_0000090)
 
 # Class: obo:EMPTY_0000025 (elevated plus maze: closed arm (west) - entries)
 
-AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000025 "In the Elevated Plus Maze task, this counts the number of times the animal's body fully enters the user-defined 'Closed Arm (West)' zone, representing the enclosed arm designated as 'west'. Unit of measure: count")
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000025 "In the Elevated Plus Maze task, this counts the number of times the animal's body fully enters the user-defined 'Closed Arm (West)' zone, representing the enclosed arm designated as 'west'. Unit: count")
 AnnotationAssertion(rdfs:label obo:EMPTY_0000025 "elevated plus maze: closed arm (west) - entries"@en)
 SubClassOf(obo:EMPTY_0000025 obo:EMPTY_0000003)
 
 # Class: obo:EMPTY_0000026 (elevated plus maze: closed arm (east) - entries)
 
-AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000026 "In the Elevated Plus Maze task, this counts the number of times the animal's body fully enters the user-defined 'Closed Arm (East)' zone, representing the enclosed arm designated as 'east'. Unit of measure: count")
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000026 "In the Elevated Plus Maze task, this counts the number of times the animal's body fully enters the user-defined 'Closed Arm (East)' zone, representing the enclosed arm designated as 'east'. Unit: count")
 AnnotationAssertion(rdfs:label obo:EMPTY_0000026 "elevated plus maze: closed arm (east) - entries"@en)
 SubClassOf(obo:EMPTY_0000026 obo:EMPTY_0000003)
 
 # Class: obo:EMPTY_0000027 (elevated plus maze: closed arm total entries)
 
-AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000027 "In the Elevated Plus Maze task, this is the total number of times the animal's body fully enters any of the designated closed arm zones (e.g., 'Closed Arm (West)' and 'Closed Arm (East)'). It is often used as an indicator of general locomotor activity. Unit of measure: count")
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000027 "In the Elevated Plus Maze task, this is the total number of times the animal's body fully enters any of the designated closed arm zones (e.g., 'Closed Arm (West)' and 'Closed Arm (East)'). It is often used as an indicator of general locomotor activity. Unit: count")
 AnnotationAssertion(rdfs:label obo:EMPTY_0000027 "elevated plus maze: closed arm total entries"@en)
 SubClassOf(obo:EMPTY_0000027 obo:EMPTY_0000003)
 
 # Class: obo:EMPTY_0000028 (elevated plus maze: closed arm (west) - head entries)
 
-AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000028 "In the Elevated Plus Maze task, this counts the number of times the animal's head enters the user-defined 'Closed Arm (West)' zone. Unit of measure: count")
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000028 "In the Elevated Plus Maze task, this counts the number of times the animal's head enters the user-defined 'Closed Arm (West)' zone. Unit: count")
 AnnotationAssertion(rdfs:label obo:EMPTY_0000028 "elevated plus maze: closed arm (west) - head entries"@en)
 SubClassOf(obo:EMPTY_0000028 obo:EMPTY_0000003)
 
 # Class: obo:EMPTY_0000029 (elevated plus maze: closed arm (east) - head entries)
 
-AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000029 "In the Elevated Plus Maze task, this counts the number of times the animal's head enters the user-defined 'Closed Arm (East)' zone. Unit of measure: count")
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000029 "In the Elevated Plus Maze task, this counts the number of times the animal's head enters the user-defined 'Closed Arm (East)' zone. Unit: count")
 AnnotationAssertion(rdfs:label obo:EMPTY_0000029 "elevated plus maze: closed arm (east) - head entries"@en)
 SubClassOf(obo:EMPTY_0000029 obo:EMPTY_0000003)
 
 # Class: obo:EMPTY_0000030 (elevated plus maze: closed arm total head entries)
 
-AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000030 "In the Elevated Plus Maze task, this is the total number of times the animal's head enters any of the designated closed arm zones (e.g., 'Closed Arm (West)' and 'Closed Arm (East)'). Unit of measure: count")
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000030 "In the Elevated Plus Maze task, this is the total number of times the animal's head enters any of the designated closed arm zones (e.g., 'Closed Arm (West)' and 'Closed Arm (East)'). Unit: count")
 AnnotationAssertion(rdfs:label obo:EMPTY_0000030 "elevated plus maze: closed arm total head entries"@en)
 SubClassOf(obo:EMPTY_0000030 obo:EMPTY_0000003)
 
 # Class: obo:EMPTY_0000031 (elevated plus maze: closed arm (west) - time)
 
-AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000031 "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Closed Arm (West)' zone. Unit of measure: seconds")
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000031 "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Closed Arm (West)' zone. Unit: seconds")
 AnnotationAssertion(rdfs:label obo:EMPTY_0000031 "elevated plus maze: closed arm (west) - time"@en)
 SubClassOf(obo:EMPTY_0000031 obo:EMPTY_0000003)
 SubClassOf(obo:EMPTY_0000031 obo:EMPTY_0000090)
 
 # Class: obo:EMPTY_0000032 (elevated plus maze: closed arm (east) - time)
 
-AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000032 "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Closed Arm (East)' zone. Unit of measure: seconds")
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000032 "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Closed Arm (East)' zone. Unit: seconds")
 AnnotationAssertion(rdfs:label obo:EMPTY_0000032 "elevated plus maze: closed arm (east) - time"@en)
 SubClassOf(obo:EMPTY_0000032 obo:EMPTY_0000003)
 SubClassOf(obo:EMPTY_0000032 obo:EMPTY_0000090)
 
 # Class: obo:EMPTY_0000033 (elevated plus maze: closed arm total time)
 
-AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000033 "In the Elevated Plus Maze task, this is the cumulative total duration the animal's body spends within any of the designated closed arm zones (e.g., 'Closed Arm (West)' and 'Closed Arm (East)'). Animals typically spend more time in these 'safer' areas. Unit of measure: seconds")
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000033 "In the Elevated Plus Maze task, this is the cumulative total duration the animal's body spends within any of the designated closed arm zones (e.g., 'Closed Arm (West)' and 'Closed Arm (East)'). Animals typically spend more time in these 'safer' areas. Unit: seconds")
 AnnotationAssertion(rdfs:label obo:EMPTY_0000033 "elevated plus maze: closed arm total time"@en)
 SubClassOf(obo:EMPTY_0000033 obo:EMPTY_0000003)
 SubClassOf(obo:EMPTY_0000033 obo:EMPTY_0000090)
 
 # Class: obo:EMPTY_0000034 (elevated plus maze: closed arm total - percent time during test duration)
 
-AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000034 "In the Elevated Plus Maze task, this represents the percentage of the total test duration that the animal spends in any of the designated closed arm zones (e.g., 'Closed Arm (West)' and 'Closed Arm (East)'). Unit of measure: %")
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000034 "In the Elevated Plus Maze task, this represents the percentage of the total test duration that the animal spends in any of the designated closed arm zones (e.g., 'Closed Arm (West)' and 'Closed Arm (East)'). Unit: %")
 AnnotationAssertion(rdfs:label obo:EMPTY_0000034 "elevated plus maze: closed arm total - percent time during test duration"@en)
 SubClassOf(obo:EMPTY_0000034 obo:EMPTY_0000003)
 
 # Class: obo:EMPTY_0000035 (elevated plus maze: closed arm (west) - latency to first entry)
 
-AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000035 "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Closed Arm (West)' zone. Unit of measure: seconds")
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000035 "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Closed Arm (West)' zone. Unit: seconds")
 AnnotationAssertion(rdfs:label obo:EMPTY_0000035 "elevated plus maze: closed arm (west) - latency to first entry"@en)
 SubClassOf(obo:EMPTY_0000035 obo:EMPTY_0000003)
 SubClassOf(obo:EMPTY_0000035 obo:EMPTY_0000091)
 
 # Class: obo:EMPTY_0000036 (elevated plus maze: closed arm (east) - latency to first entry)
 
-AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000036 "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Closed Arm (East)' zone. Unit of measure: seconds")
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000036 "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Closed Arm (East)' zone. Unit: seconds")
 AnnotationAssertion(rdfs:label obo:EMPTY_0000036 "elevated plus maze: closed arm (east) - latency to first entry"@en)
 SubClassOf(obo:EMPTY_0000036 obo:EMPTY_0000003)
 SubClassOf(obo:EMPTY_0000036 obo:EMPTY_0000091)
 
 # Class: obo:EMPTY_0000037 (elevated plus maze: closed arm total latency to first entry)
 
-AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000037 "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into any of the designated closed arm zones (e.g., 'Closed Arm (West)' or 'Closed Arm (East)'). Unit of measure: seconds")
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000037 "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into any of the designated closed arm zones (e.g., 'Closed Arm (West)' or 'Closed Arm (East)'). Unit: seconds")
 AnnotationAssertion(rdfs:label obo:EMPTY_0000037 "elevated plus maze: closed arm total latency to first entry"@en)
 SubClassOf(obo:EMPTY_0000037 obo:EMPTY_0000003)
 SubClassOf(obo:EMPTY_0000037 obo:EMPTY_0000091)
 
 # Class: obo:EMPTY_0000038 (elevated plus maze: closed arm (west) - time moving towards)
 
-AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000038 "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Closed Arm (West)' zone. Unit of measure: seconds")
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000038 "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Closed Arm (West)' zone. Unit: seconds")
 AnnotationAssertion(rdfs:label obo:EMPTY_0000038 "elevated plus maze: closed arm (west) - time moving towards"@en)
 SubClassOf(obo:EMPTY_0000038 obo:EMPTY_0000003)
 SubClassOf(obo:EMPTY_0000038 obo:EMPTY_0000090)
 
 # Class: obo:EMPTY_0000039 (elevated plus maze: closed arm (east) - time moving towards)
 
-AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000039 "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Closed Arm (East)' zone. Unit of measure: seconds")
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000039 "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Closed Arm (East)' zone. Unit: seconds")
 AnnotationAssertion(rdfs:label obo:EMPTY_0000039 "elevated plus maze: closed arm (east) - time moving towards"@en)
 SubClassOf(obo:EMPTY_0000039 obo:EMPTY_0000003)
 SubClassOf(obo:EMPTY_0000039 obo:EMPTY_0000090)
 
 # Class: obo:EMPTY_0000040 (elevated plus maze: closed arm total time moving towards)
 
-AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000040 "In the Elevated Plus Maze task, this is the cumulative duration the animal spends actively moving towards any of the designated closed arm zones (e.g., 'Closed Arm (West)' or 'Closed Arm (East)'). Unit of measure: seconds")
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000040 "In the Elevated Plus Maze task, this is the cumulative duration the animal spends actively moving towards any of the designated closed arm zones (e.g., 'Closed Arm (West)' or 'Closed Arm (East)'). Unit: seconds")
 AnnotationAssertion(rdfs:label obo:EMPTY_0000040 "elevated plus maze: closed arm total time moving towards"@en)
 SubClassOf(obo:EMPTY_0000040 obo:EMPTY_0000003)
 SubClassOf(obo:EMPTY_0000040 obo:EMPTY_0000090)
 
 # Class: obo:EMPTY_0000041 (elevated plus maze: closed arm (west) - time freezing)
 
-AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000041 "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined 'Closed Arm (West)' zone. Unit of measure: seconds")
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000041 "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined 'Closed Arm (West)' zone. Unit: seconds")
 AnnotationAssertion(rdfs:label obo:EMPTY_0000041 "elevated plus maze: closed arm (west) - time freezing"@en)
 SubClassOf(obo:EMPTY_0000041 obo:EMPTY_0000003)
 SubClassOf(obo:EMPTY_0000041 obo:EMPTY_0000090)
 
 # Class: obo:EMPTY_0000042 (elevated plus maze: closed arm (east) - time freezing)
 
-AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000042 "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined 'Closed Arm (East)' zone. Unit of measure: seconds")
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000042 "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined 'Closed Arm (East)' zone. Unit: seconds")
 AnnotationAssertion(rdfs:label obo:EMPTY_0000042 "elevated plus maze: closed arm (east) - time freezing"@en)
 SubClassOf(obo:EMPTY_0000042 obo:EMPTY_0000003)
 SubClassOf(obo:EMPTY_0000042 obo:EMPTY_0000090)
 
 # Class: obo:EMPTY_0000043 (elevated plus maze: closed arm total time freezing)
 
-AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000043 "In the Elevated Plus Maze task, this is the cumulative duration the animal exhibits freezing behavior while within any of the designated closed arm zones (e.g., 'Closed Arm (West)' or 'Closed Arm (East)'). Unit of measure: seconds")
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000043 "In the Elevated Plus Maze task, this is the cumulative duration the animal exhibits freezing behavior while within any of the designated closed arm zones (e.g., 'Closed Arm (West)' or 'Closed Arm (East)'). Unit: seconds")
 AnnotationAssertion(rdfs:label obo:EMPTY_0000043 "elevated plus maze: closed arm total time freezing"@en)
 SubClassOf(obo:EMPTY_0000043 obo:EMPTY_0000003)
 SubClassOf(obo:EMPTY_0000043 obo:EMPTY_0000090)
 
 # Class: obo:EMPTY_0000044 (elevated plus maze: center - entries)
 
-AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000044 "In the Elevated Plus Maze task, this counts the number of times the animal's body fully enters the user-defined 'Center' zone of the maze, typically from one of the arms. The center zone is the area where all four arms meet. Unit of measure: count")
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000044 "In the Elevated Plus Maze task, this counts the number of times the animal's body fully enters the user-defined 'Center' zone of the maze, typically from one of the arms. The center zone is the area where all four arms meet. Unit: count")
 AnnotationAssertion(rdfs:label obo:EMPTY_0000044 "elevated plus maze: center - entries"@en)
 SubClassOf(obo:EMPTY_0000044 obo:EMPTY_0000003)
 
 # Class: obo:EMPTY_0000045 (elevated plus maze: center - head entries)
 
-AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000045 "In the Elevated Plus Maze task, this counts the number of times the animal's head enters the user-defined 'Center' zone of the maze. Unit of measure: count")
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000045 "In the Elevated Plus Maze task, this counts the number of times the animal's head enters the user-defined 'Center' zone of the maze. Unit: count")
 AnnotationAssertion(rdfs:label obo:EMPTY_0000045 "elevated plus maze: center - head entries"@en)
 SubClassOf(obo:EMPTY_0000045 obo:EMPTY_0000003)
 
 # Class: obo:EMPTY_0000046 (elevated plus maze: center - time)
 
-AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000046 "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Center' zone. Time in the center can indicate decision-making or risk assessment. Unit of measure: seconds")
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000046 "In the Elevated Plus Maze task, this measures the total duration the animal's body spends within the user-defined 'Center' zone. Time in the center can indicate decision-making or risk assessment. Unit: seconds")
 AnnotationAssertion(rdfs:label obo:EMPTY_0000046 "elevated plus maze: center - time"@en)
 SubClassOf(obo:EMPTY_0000046 obo:EMPTY_0000003)
 SubClassOf(obo:EMPTY_0000046 obo:EMPTY_0000090)
 
 # Class: obo:EMPTY_0000047 (elevated plus maze: center - percent time during test duration)
 
-AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000047 "In the Elevated Plus Maze task, this represents the percentage of the total test duration that the animal spends in the user-defined 'Center' zone of the maze. Unit of measure: %")
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000047 "In the Elevated Plus Maze task, this represents the percentage of the total test duration that the animal spends in the user-defined 'Center' zone of the maze. Unit: %")
 AnnotationAssertion(rdfs:label obo:EMPTY_0000047 "elevated plus maze: center - percent time during test duration"@en)
 SubClassOf(obo:EMPTY_0000047 obo:EMPTY_0000003)
 
 # Class: obo:EMPTY_0000048 (elevated plus maze: center - latency to first entry)
 
-AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000048 "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Center' zone. If the animal starts in the center, this value may be zero or not applicable. Unit of measure: seconds")
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000048 "In the Elevated Plus Maze task, this measures the time elapsed from the start of the test until the animal makes its first full body entry into the user-defined 'Center' zone. If the animal starts in the center, this value may be zero or not applicable. Unit: seconds")
 AnnotationAssertion(rdfs:label obo:EMPTY_0000048 "elevated plus maze: center - latency to first entry"@en)
 SubClassOf(obo:EMPTY_0000048 obo:EMPTY_0000003)
 SubClassOf(obo:EMPTY_0000048 obo:EMPTY_0000091)
 
 # Class: obo:EMPTY_0000049 (elevated plus maze: center - time moving towards)
 
-AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000049 "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Center' zone of the maze (e.g., from an arm). Unit of measure: seconds")
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000049 "In the Elevated Plus Maze task, this measures the total duration the animal spends actively moving towards the user-defined 'Center' zone of the maze (e.g., from an arm). Unit: seconds")
 AnnotationAssertion(rdfs:label obo:EMPTY_0000049 "elevated plus maze: center - time moving towards"@en)
 SubClassOf(obo:EMPTY_0000049 obo:EMPTY_0000003)
 SubClassOf(obo:EMPTY_0000049 obo:EMPTY_0000090)
 
 # Class: obo:EMPTY_0000050 (elevated plus maze: center - time freezing)
 
-AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000050 "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined 'Center' zone of the maze. Freezing in this relatively exposed area can indicate high anxiety. Unit of measure: seconds")
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000050 "In the Elevated Plus Maze task, this measures the total duration the animal exhibits freezing behavior while within the user-defined 'Center' zone of the maze. Freezing in this relatively exposed area can indicate high anxiety. Unit: seconds")
 AnnotationAssertion(rdfs:label obo:EMPTY_0000050 "elevated plus maze: center - time freezing"@en)
 SubClassOf(obo:EMPTY_0000050 obo:EMPTY_0000003)
 SubClassOf(obo:EMPTY_0000050 obo:EMPTY_0000090)
@@ -653,7 +684,7 @@ SubClassOf(obo:EMPTY_0000052 obo:EMPTY_0000084)
 
 # Class: obo:EMPTY_0000053 (fear-potentiated startle: baseline acoustic startle response amplitude)
 
-AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000053 "In the Fear-potentiated startle paradigm, this is the amplitude of the acoustic startle response (ASR) measured in response to a startle-eliciting stimulus (e.g., 95-dB white noise burst) prior to any fear conditioning procedures, typically assessed during habituation or pre-conditioning phase. This measurement serves as a reference point for later comparisons with post-conditioning startle responses. Unit of measure: arbitrary units or standardized score.")
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000053 "In the Fear-potentiated startle paradigm, this is the amplitude of the acoustic startle response (ASR) measured in response to a startle-eliciting stimulus (e.g., 95-dB white noise burst) prior to any fear conditioning procedures, typically assessed during habituation or pre-conditioning phase. This measurement serves as a reference point for later comparisons with post-conditioning startle responses. Unit: arbitrary units or standardized score.")
 AnnotationAssertion(rdfs:label obo:EMPTY_0000053 "fear-potentiated startle: baseline acoustic startle response amplitude"@en)
 SubClassOf(obo:EMPTY_0000053 obo:EMPTY_0000004)
 SubClassOf(obo:EMPTY_0000053 obo:EMPTY_0000162)
@@ -685,7 +716,7 @@ SubClassOf(obo:EMPTY_0000057 obo:EMPTY_0000093)
 
 # Class: obo:EMPTY_0000058 (fear-potentiated startle: apparatus chamber identifier)
 
-AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000058 "Identifier for the specific Plexiglas enclosure or sound-attenuating chamber within the Fear-Potentiated Startle (FPS) apparatus (e.g., San Diego Instruments SR-Lab) in which a subject was tested for a given trial. Unit of measure: count or identifier string")
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000058 "Identifier for the specific Plexiglas enclosure or sound-attenuating chamber within the Fear-Potentiated Startle (FPS) apparatus (e.g., San Diego Instruments SR-Lab) in which a subject was tested for a given trial. Unit: count or identifier string")
 AnnotationAssertion(rdfs:label obo:EMPTY_0000058 "fear-potentiated startle: apparatus chamber identifier"@en)
 SubClassOf(obo:EMPTY_0000058 obo:EMPTY_0000093)
 
@@ -697,40 +728,40 @@ SubClassOf(obo:EMPTY_0000059 obo:EMPTY_0000084)
 
 # Class: obo:EMPTY_0000060 (acoustic startle response: number of samples)
 
-AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000060 "The total number of data points (samples) recorded and analyzed for a single acoustic startle response, typically within a defined time window following stimulus onset (e.g., a 200-ms window as mentioned in the manuscript). Unit of measure: count")
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000060 "The total number of data points (samples) recorded and analyzed for a single acoustic startle response, typically within a defined time window following stimulus onset (e.g., a 200-ms window as mentioned in the manuscript). Unit: count")
 AnnotationAssertion(rdfs:label obo:EMPTY_0000060 "acoustic startle response: number of samples"@en)
 SubClassOf(obo:EMPTY_0000060 obo:EMPTY_0000093)
 
 # Class: obo:EMPTY_0000061 (acoustic startle response: sampling rate)
 
-AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000061 "The rate at which the analog startle response signal was digitized during data acquisition. Unit of measure: Hertz (Hz)")
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000061 "The rate at which the analog startle response signal was digitized during data acquisition. Unit: Hertz (Hz)")
 AnnotationAssertion(rdfs:label obo:EMPTY_0000061 "acoustic startle response: sampling rate"@en)
 SubClassOf(obo:EMPTY_0000061 obo:EMPTY_0000093)
 
 # Class: obo:EMPTY_0000062 (acoustic startle response: startle window onset amplitude)
 
-AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000062 "The amplitude of the digitized acoustic startle response signal at the very beginning (onset) of the defined analysis window (e.g., a 200-ms window) used to quantify the reflex. Unit of measure: millivolts (mV) or arbitrary units based on transducer calibration.")
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000062 "The amplitude of the digitized acoustic startle response signal at the very beginning (onset) of the defined analysis window (e.g., a 200-ms window) used to quantify the reflex. Unit: millivolts (mV) or arbitrary units based on transducer calibration.")
 AnnotationAssertion(rdfs:label obo:EMPTY_0000062 "acoustic startle response: startle window onset amplitude"@en)
 SubClassOf(obo:EMPTY_0000062 obo:EMPTY_0000004)
 SubClassOf(obo:EMPTY_0000062 obo:EMPTY_0000162)
 
 # Class: obo:EMPTY_0000063 (acoustic startle response: maximum amplitude)
 
-AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000063 "The peak amplitude of the acoustic startle response (e.g., 'jump amplitude') detected within the defined analysis window (e.g., 200-ms window) for a given trial. Unit of measure: millivolts (mV) or arbitrary units.")
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000063 "The peak amplitude of the acoustic startle response (e.g., 'jump amplitude') detected within the defined analysis window (e.g., 200-ms window) for a given trial. Unit: millivolts (mV) or arbitrary units.")
 AnnotationAssertion(rdfs:label obo:EMPTY_0000063 "acoustic startle response: maximum amplitude"@en)
 SubClassOf(obo:EMPTY_0000063 obo:EMPTY_0000004)
 SubClassOf(obo:EMPTY_0000063 obo:EMPTY_0000162)
 
 # Class: obo:EMPTY_0000064 (acoustic startle response: time to maximum amplitude)
 
-AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000064 "The latency from the onset of the startle-eliciting stimulus (or the beginning of the analysis window) to the occurrence of the maximum (peak) amplitude of the acoustic startle response. Unit of measure: milliseconds (ms)")
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000064 "The latency from the onset of the startle-eliciting stimulus (or the beginning of the analysis window) to the occurrence of the maximum (peak) amplitude of the acoustic startle response. Unit: milliseconds (ms)")
 AnnotationAssertion(rdfs:label obo:EMPTY_0000064 "acoustic startle response: time to maximum amplitude"@en)
 SubClassOf(obo:EMPTY_0000064 obo:EMPTY_0000004)
 SubClassOf(obo:EMPTY_0000064 obo:EMPTY_0000091)
 
 # Class: obo:EMPTY_0000065 (acoustic startle response: average amplitude)
 
-AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000065 "The average amplitude of the digitized acoustic startle response signal calculated across the entire duration of the defined analysis window (e.g., 200-ms window). Unit of measure: millivolts (mV) or arbitrary units.")
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000065 "The average amplitude of the digitized acoustic startle response signal calculated across the entire duration of the defined analysis window (e.g., 200-ms window). Unit: millivolts (mV) or arbitrary units.")
 AnnotationAssertion(rdfs:label obo:EMPTY_0000065 "acoustic startle response: average amplitude"@en)
 SubClassOf(obo:EMPTY_0000065 obo:EMPTY_0000004)
 SubClassOf(obo:EMPTY_0000065 obo:EMPTY_0000162)
@@ -750,7 +781,7 @@ SubClassOf(obo:EMPTY_0000067 obo:EMPTY_0000093)
 
 # Class: obo:EMPTY_0000068 (elevated plus maze: test duration)
 
-AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000068 "In the Elevated Plus Maze task, this is the time of the total test duration in seconds'). Unit of measure: seconds")
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000068 "In the Elevated Plus Maze task, this is the time of the total test duration in seconds'). Unit: seconds")
 AnnotationAssertion(rdfs:label obo:EMPTY_0000068 "elevated plus maze: test duration"@en)
 SubClassOf(obo:EMPTY_0000068 obo:EMPTY_0000003)
 SubClassOf(obo:EMPTY_0000068 obo:EMPTY_0000090)
@@ -1455,13 +1486,13 @@ SubClassOf(obo:EMPTY_0000174 obo:EMPTY_0000164)
 
 # Class: obo:EMPTY_0000175 (contextual fear conditioning: time freezing)
 
-AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000175 "The number of seconds the individual spent freezing during a given period of time. Unit of measure: seconds")
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000175 "The number of seconds the individual spent freezing during a given period of time. Unit: seconds")
 AnnotationAssertion(rdfs:label obo:EMPTY_0000175 "contextual fear conditioning: time freezing"@en)
 SubClassOf(obo:EMPTY_0000175 obo:EMPTY_0000163)
 
 # Class: obo:EMPTY_0000176 (contextual fear conditioning: block duration)
 
-AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000176 "In the contextual fear conditioning paradigm, this is the time of the block duration in seconds. Unit of measure: seconds")
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000176 "In the contextual fear conditioning paradigm, this is the time of the block duration in seconds. Unit: seconds")
 AnnotationAssertion(rdfs:label obo:EMPTY_0000176 "contextual fear conditioning: block duration"@en)
 SubClassOf(obo:EMPTY_0000176 obo:EMPTY_0000163)
 SubClassOf(obo:EMPTY_0000176 obo:EMPTY_0000164)
@@ -1801,5 +1832,173 @@ AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000230 "A digital file for which
 AnnotationAssertion(rdfs:label obo:EMPTY_0000230 "unknown electronic file type"@en)
 SubClassOf(obo:EMPTY_0000230 obo:NCIT_C172272)
 
+# Class: obo:EMPTY_0000231 (C. elegans chemotaxis assay parameter)
+
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000231 "A parameter that specifies the technical settings, environmental conditions, or experimental design of a chemotaxis assay involving Caenorhabditis elegans.")
+AnnotationAssertion(rdfs:label obo:EMPTY_0000231 "C. elegans chemotaxis assay parameter"@en)
+SubClassOf(obo:EMPTY_0000231 obo:EMPTY_0000101)
+
+# Class: obo:EMPTY_0000232 (C. elegans chemotaxis assay parameter: chemoattractant mixture table)
+
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000232 "A table containing the quantities and identities of all chemicals used as a chemoattractant (e.g., isoamyl alcohol, diacetyl) to elicit a directed movement response in C. elegans.")
+AnnotationAssertion(rdfs:label obo:EMPTY_0000232 "C. elegans chemotaxis assay parameter: chemoattractant mixture table"@en)
+SubClassOf(obo:EMPTY_0000232 obo:EMPTY_0000231)
+
+# Class: obo:EMPTY_0000233 (C. elegans chemotaxis assay parameter: chemoattractant mixture volume)
+
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000233 "The volume of the chemoattractant mixture pipetted onto the agar plate in a chemotaxis assay. Unit: microliters (μL).")
+AnnotationAssertion(rdfs:label obo:EMPTY_0000233 "C. elegans chemotaxis assay parameter: chemoattractant mixture volume"@en)
+SubClassOf(obo:EMPTY_0000233 obo:EMPTY_0000231)
+
+# Class: obo:EMPTY_0000234 (C. elegans chemotaxis assay parameter: assay duration)
+
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000234 "The total time elapsed from the point at which C. elegans are placed on the assay plate until the movement is arrested or the final positions are recorded. Unit: minutes.")
+AnnotationAssertion(rdfs:label obo:EMPTY_0000234 "C. elegans chemotaxis assay parameter: assay duration"@en)
+SubClassOf(obo:EMPTY_0000234 obo:EMPTY_0000231)
+
+# Class: obo:EMPTY_0000235 (C. elegans chemotaxis assay measurement)
+
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000235 "A quantitative or qualitative value derived from a C. elegans chemotaxis assay, typically describing the efficiency or directionality of the animals' movement toward or away from a chemical source.")
+AnnotationAssertion(rdfs:label obo:EMPTY_0000235 "C. elegans chemotaxis assay measurement"@en)
+SubClassOf(obo:EMPTY_0000235 obo:EMPTY_0000100)
+
+# Class: obo:EMPTY_0000236 (C. elegans chemotaxis assay measurement: McCutcheon index)
+
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000236 "A behavioral measurement of chemotactic efficiency defined as the ratio of the straight-line displacement toward the attractant to the total path length traveled by the organism. Values range from -1 to 1.")
+AnnotationAssertion(oboInOwl:hasExactSynonym obo:EMPTY_0000236 "chemotactic ratio"@en)
+AnnotationAssertion(rdfs:label obo:EMPTY_0000236 "C. elegans chemotaxis assay measurement: McCutcheon index"@en)
+SubClassOf(obo:EMPTY_0000236 obo:EMPTY_0000235)
+
+# Class: obo:EMPTY_0000237 (C. elegans chemotaxis assay measurement: mean velocity)
+
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000237 "The average speed of a C. elegans individual or population during the duration of the chemotaxis assay. Unit: micrometers per second (µm/s).")
+AnnotationAssertion(rdfs:label obo:EMPTY_0000237 "C. elegans chemotaxis assay measurement: mean velocity"@en)
+SubClassOf(obo:EMPTY_0000237 obo:EMPTY_0000235)
+
+# Class: obo:EMPTY_0000238 (investigator-defined strain)
+
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000238 "A specific genetic variant or line of an organism designated by the investigator, often containing unique mutations, transgenes, or genomic edits not yet categorized in a public repository.")
+AnnotationAssertion(rdfs:label obo:EMPTY_0000238 "investigator-defined strain"@en)
+SubClassOf(obo:EMPTY_0000238 obo:EMPTY_0000076)
+
+# Class: obo:EMPTY_0000239 (C. elegans strain)
+
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000239 "A specific strain of Caenorhabditis elegans, identified by its genotype or a standard nomenclature (e.g., N2, CB4856), used in experimental procedures.")
+AnnotationAssertion(rdfs:label obo:EMPTY_0000239 "C. elegans strain"@en)
+SubClassOf(obo:EMPTY_0000239 obo:EMPTY_0000238)
+
+# Class: obo:EMPTY_0000240 (BAB9001)
+
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000240 "A C. elegans strain with the genotype daf-22 (m130). This strain was originally obtained from the Caenorhabditis Genetics Center (CGC) as strain DR476 and subsequently outcrossed three times. [Source: https://doi.org/TBD]")
+AnnotationAssertion(rdfs:label obo:EMPTY_0000240 "BAB9001"@en)
+SubClassOf(obo:EMPTY_0000240 obo:EMPTY_0000239)
+
+# Class: obo:EMPTY_0000241 (BAB9002)
+
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000241 "A C. elegans klp-6 rescue strain with the genotype klp-6 (my8); Pklp-6::GFP::KLP-6 (array, IndEx 9002). [Source: https://doi.org/TBD]")
+AnnotationAssertion(rdfs:label obo:EMPTY_0000241 "BAB9002"@en)
+SubClassOf(obo:EMPTY_0000241 obo:EMPTY_0000239)
+
+# Class: obo:EMPTY_0000242 (TM5848)
+
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000242 "A C. elegans strain with the genotype cil-7 (tm5848) I, exhibiting a him phenotype. This strain was obtained from the National BioResource Project (NBRP), Japan. [Source: https://doi.org/TBD]")
+AnnotationAssertion(rdfs:label obo:EMPTY_0000242 "TM5848"@en)
+SubClassOf(obo:EMPTY_0000242 obo:EMPTY_0000239)
+
+# Class: obo:EMPTY_0000243 (PT3602)
+
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000243 "A C. elegans strain with the genotype cil-7 (my61[cil-7::mNG])I; him-5(e1490) V. This strain was provided as a gift from the Maureen Barr lab. [Source: https://doi.org/TBD]")
+AnnotationAssertion(rdfs:label obo:EMPTY_0000243 "PT3602"@en)
+SubClassOf(obo:EMPTY_0000243 obo:EMPTY_0000239)
+
+# Class: obo:EMPTY_0000244 (BAB9003)
+
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000244 "A C. elegans strain with the genotype PT3602; Pnlp-43_hCaspase nZ (array IndEx 9003). [Source: https://doi.org/TBD]")
+AnnotationAssertion(rdfs:label obo:EMPTY_0000244 "BAB9003"@en)
+SubClassOf(obo:EMPTY_0000244 obo:EMPTY_0000239)
+
+# Class: obo:EMPTY_0000245 (BAB9004)
+
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000245 "A C. elegans strain with the genotype PT3602; Pklp-6_hCaspase Cz (array IndEx 9004). [Source: https://doi.org/TBD]")
+AnnotationAssertion(rdfs:label obo:EMPTY_0000245 "BAB9004"@en)
+SubClassOf(obo:EMPTY_0000245 obo:EMPTY_0000239)
+
+# Class: obo:EMPTY_0000246 (BAB9005)
+
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000246 "A C. elegans strain with the genotype PT3602; Pnlp-43_hCaspase nZ (array IndEx 9003) and Pklp-6_hCaspase Cz (array IndEx 9004). [Source: https://doi.org/TBD]")
+AnnotationAssertion(rdfs:label obo:EMPTY_0000246 "BAB9005"@en)
+SubClassOf(obo:EMPTY_0000246 obo:EMPTY_0000239)
+
+# Class: obo:EMPTY_0000247 (fluorescence imaging measurement)
+
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000247 "fluorescence imaging measurement")
+AnnotationAssertion(rdfs:label obo:EMPTY_0000247 "fluorescence imaging measurement"@en)
+SubClassOf(obo:EMPTY_0000247 obo:EMPTY_0000001)
+
+# Class: obo:EMPTY_0000248 (mean fluorescence intensity)
+
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000248 "Mean fluorescence intensity. Unit: arbitrary units (AU)")
+AnnotationAssertion(rdfs:label obo:EMPTY_0000248 "mean fluorescence intensity"@en)
+SubClassOf(obo:EMPTY_0000248 obo:EMPTY_0000247)
+
+# Class: obo:EMPTY_0000249 (fluorescent punctal count)
+
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000249 "A quantitative measurement of the number of distinct fluorescent spots or puncta detected within a defined region of interest in a fluorescence image. Unit: count")
+AnnotationAssertion(rdfs:label obo:EMPTY_0000249 "fluorescent punctal count"@en)
+SubClassOf(obo:EMPTY_0000249 obo:EMPTY_0000247)
+
+# Class: obo:EMPTY_0000250 (fluorescence imaging parameter)
+
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000250 "A specific parameter related to fluorescence imaging acquisition or assay.")
+AnnotationAssertion(rdfs:label obo:EMPTY_0000250 "fluorescence imaging parameter"@en)
+SubClassOf(obo:EMPTY_0000250 obo:EMPTY_0000080)
+
+# Class: obo:EMPTY_0000251 (fluorescence target ontology identifier)
+
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000251 "fluorescence target ontology identifier")
+AnnotationAssertion(rdfs:label obo:EMPTY_0000251 "fluorescence target ontology identifier"@en)
+SubClassOf(obo:EMPTY_0000251 obo:EMPTY_0000250)
+
+# Class: obo:EMPTY_0000252 (fluorescence target name)
+
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000252 "fluorescence target name")
+AnnotationAssertion(rdfs:label obo:EMPTY_0000252 "fluorescence target name"@en)
+SubClassOf(obo:EMPTY_0000252 obo:EMPTY_0000250)
+
+# Class: obo:EMPTY_0000253 (SnapGene file format)
+
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000253 "A .dna file format designed for storing annotated DNA sequences, including linear/circular topology, features, primers, and enzyme sites.")
+AnnotationAssertion(rdfs:label obo:EMPTY_0000253 "SnapGene file format"@en)
+SubClassOf(obo:EMPTY_0000253 obo:format_1929)
+
+# Class: obo:EMPTY_0000254 (Escherichia coli OP50: heat-killed)
+
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000254 "A preparation of Escherichia coli strain OP50 that has been rendered non-viable through the application of heat, typically used as a non-proliferating food source in C. elegans assays.")
+AnnotationAssertion(rdfs:label obo:EMPTY_0000254 "Escherichia coli OP50: heat-killed"@en)
+SubClassOf(obo:EMPTY_0000254 obo:NCBITaxon_637912)
+
+# Class: obo:EMPTY_0000255 (C. elegans transfer method: M9 buffer wash)
+
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000255 "Method used to transfer C. elegans whereby an M9 buffer is used to wash C. elegans off of an agar plate. Animals can then be transferred using a piper.")
+AnnotationAssertion(rdfs:label obo:EMPTY_0000255 "C. elegans transfer method: M9 buffer wash"@en)
+SubClassOf(obo:EMPTY_0000255 obo:EMPTY_0000189)
+
+# Class: obo:EMPTY_0000256 (C. elegans transfer method: titanium pick)
+
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000256 "Method used to transfer C. elegans whereby a titanium pick is used to scoop animals off of an agar plate.")
+AnnotationAssertion(rdfs:label obo:EMPTY_0000256 "C. elegans transfer method: titanium pick"@en)
+SubClassOf(obo:EMPTY_0000256 obo:EMPTY_0000189)
+
+# Class: obo:EMPTY_0000257 (C. elegans chemotaxis assay: video recording)
+
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000257 "A video recording capturing the behavior of C. elegans during a chemotaxis assay.")
+AnnotationAssertion(rdfs:label obo:EMPTY_0000257 "C. elegans chemotaxis assay: video recording"@en)
+SubClassOf(obo:EMPTY_0000257 obo:EMPTY_0000129)
+
+# Class: obo:EMPTY_0000258 (fluorescence imaging data)
+
+AnnotationAssertion(obo:IAO_0000115 obo:EMPTY_0000258 "An image or video acquired using fluorescence microscopy.")
+AnnotationAssertion(rdfs:label obo:EMPTY_0000258 "fluorescence imaging data"@en)
+SubClassOf(obo:EMPTY_0000258 obo:NCIT_C16856)
 
 )
\ No newline at end of file
diff --git a/src/ontology/empty-edit.properties b/src/ontology/empty-edit.properties
index ea31aeb..d83ca5c 100644
--- a/src/ontology/empty-edit.properties
+++ b/src/ontology/empty-edit.properties
@@ -1,4 +1,4 @@
-#Thu Feb 12 19:34:43 GMT 2026
+#Mon Mar 30 22:06:40 BST 2026
 jdbc.password=
 jdbc.user=
 jdbc.url=
diff --git a/src/ontology/imports/ncbitaxon_import.owl b/src/ontology/imports/ncbitaxon_import.owl
index 1a971f2..b870c5b 100644
--- a/src/ontology/imports/ncbitaxon_import.owl
+++ b/src/ontology/imports/ncbitaxon_import.owl
@@ -7,11 +7,13 @@ Prefix(rdfs:=<http://www.w3.org/2000/01/rdf-schema#>)
 
 
 Ontology(<http://purl.obolibrary.org/obo/empty/imports/ncbitaxon_import.owl>
-<http://purl.obolibrary.org/obo/empty/releases/2026-02-23/imports/ncbitaxon_import.owl>
+<http://purl.obolibrary.org/obo/empty/releases/2026-04-04/imports/ncbitaxon_import.owl>
 Annotation(<http://purl.org/dc/elements/1.1/source> <http://purl.obolibrary.org/obo/ncbitaxon/2025-12-03/ncbitaxon.owl>)
-Annotation(owl:versionInfo "2026-02-23")
+Annotation(owl:versionInfo "2026-04-04")
 
 Declaration(Class(<http://purl.obolibrary.org/obo/NCBITaxon_1>))
+Declaration(Class(<http://purl.obolibrary.org/obo/NCBITaxon_1224>))
+Declaration(Class(<http://purl.obolibrary.org/obo/NCBITaxon_1236>))
 Declaration(Class(<http://purl.obolibrary.org/obo/NCBITaxon_131209>))
 Declaration(Class(<http://purl.obolibrary.org/obo/NCBITaxon_131221>))
 Declaration(Class(<http://purl.obolibrary.org/obo/NCBITaxon_131567>))
@@ -38,6 +40,7 @@ Declaration(Class(<http://purl.obolibrary.org/obo/NCBITaxon_33630>))
 Declaration(Class(<http://purl.obolibrary.org/obo/NCBITaxon_33682>))
 Declaration(Class(<http://purl.obolibrary.org/obo/NCBITaxon_3372>))
 Declaration(Class(<http://purl.obolibrary.org/obo/NCBITaxon_3378>))
+Declaration(Class(<http://purl.obolibrary.org/obo/NCBITaxon_3379134>))
 Declaration(Class(<http://purl.obolibrary.org/obo/NCBITaxon_3398>))
 Declaration(Class(<http://purl.obolibrary.org/obo/NCBITaxon_34346>))
 Declaration(Class(<http://purl.obolibrary.org/obo/NCBITaxon_35493>))
@@ -54,12 +57,17 @@ Declaration(Class(<http://purl.obolibrary.org/obo/NCBITaxon_4895>))
 Declaration(Class(<http://purl.obolibrary.org/obo/NCBITaxon_4896>))
 Declaration(Class(<http://purl.obolibrary.org/obo/NCBITaxon_4930>))
 Declaration(Class(<http://purl.obolibrary.org/obo/NCBITaxon_4932>))
+Declaration(Class(<http://purl.obolibrary.org/obo/NCBITaxon_543>))
 Declaration(Class(<http://purl.obolibrary.org/obo/NCBITaxon_554915>))
+Declaration(Class(<http://purl.obolibrary.org/obo/NCBITaxon_561>))
+Declaration(Class(<http://purl.obolibrary.org/obo/NCBITaxon_562>))
 Declaration(Class(<http://purl.obolibrary.org/obo/NCBITaxon_5782>))
 Declaration(Class(<http://purl.obolibrary.org/obo/NCBITaxon_58023>))
 Declaration(Class(<http://purl.obolibrary.org/obo/NCBITaxon_58024>))
+Declaration(Class(<http://purl.obolibrary.org/obo/NCBITaxon_637912>))
 Declaration(Class(<http://purl.obolibrary.org/obo/NCBITaxon_716545>))
 Declaration(Class(<http://purl.obolibrary.org/obo/NCBITaxon_78536>))
+Declaration(Class(<http://purl.obolibrary.org/obo/NCBITaxon_91347>))
 Declaration(AnnotationProperty(<http://purl.obolibrary.org/obo/IAO_0000115>))
 Declaration(AnnotationProperty(<http://purl.org/dc/elements/1.1/source>))
 Declaration(AnnotationProperty(<http://purl.org/dc/terms/description>))
@@ -88,6 +96,16 @@ AnnotationAssertion(rdfs:label <http://www.geneontology.org/formats/oboInOwl#has
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/NCBITaxon_1> "root")
 
+# Class: <http://purl.obolibrary.org/obo/NCBITaxon_1224> (Pseudomonadota)
+
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/NCBITaxon_1224> "Pseudomonadota")
+SubClassOf(<http://purl.obolibrary.org/obo/NCBITaxon_1224> <http://purl.obolibrary.org/obo/NCBITaxon_3379134>)
+
+# Class: <http://purl.obolibrary.org/obo/NCBITaxon_1236> (Gammaproteobacteria)
+
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/NCBITaxon_1236> "Gammaproteobacteria")
+SubClassOf(<http://purl.obolibrary.org/obo/NCBITaxon_1236> <http://purl.obolibrary.org/obo/NCBITaxon_1224>)
+
 # Class: <http://purl.obolibrary.org/obo/NCBITaxon_131209> (Zygnematophyceae)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/NCBITaxon_131209> "Zygnematophyceae")
@@ -218,6 +236,11 @@ SubClassOf(<http://purl.obolibrary.org/obo/NCBITaxon_3372> <http://purl.obolibra
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/NCBITaxon_3378> "Gnetales")
 SubClassOf(<http://purl.obolibrary.org/obo/NCBITaxon_3378> <http://purl.obolibrary.org/obo/NCBITaxon_1445966>)
 
+# Class: <http://purl.obolibrary.org/obo/NCBITaxon_3379134> (Pseudomonadati)
+
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/NCBITaxon_3379134> "Pseudomonadati")
+SubClassOf(<http://purl.obolibrary.org/obo/NCBITaxon_3379134> <http://purl.obolibrary.org/obo/NCBITaxon_2>)
+
 # Class: <http://purl.obolibrary.org/obo/NCBITaxon_3398> (Magnoliopsida)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/NCBITaxon_3398> "Magnoliopsida")
@@ -298,11 +321,26 @@ SubClassOf(<http://purl.obolibrary.org/obo/NCBITaxon_4930> <http://purl.obolibra
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/NCBITaxon_4932> "Saccharomyces cerevisiae")
 SubClassOf(<http://purl.obolibrary.org/obo/NCBITaxon_4932> <http://purl.obolibrary.org/obo/NCBITaxon_4930>)
 
+# Class: <http://purl.obolibrary.org/obo/NCBITaxon_543> (Enterobacteriaceae)
+
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/NCBITaxon_543> "Enterobacteriaceae")
+SubClassOf(<http://purl.obolibrary.org/obo/NCBITaxon_543> <http://purl.obolibrary.org/obo/NCBITaxon_91347>)
+
 # Class: <http://purl.obolibrary.org/obo/NCBITaxon_554915> (Amoebozoa)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/NCBITaxon_554915> "Amoebozoa")
 SubClassOf(<http://purl.obolibrary.org/obo/NCBITaxon_554915> <http://purl.obolibrary.org/obo/NCBITaxon_2759>)
 
+# Class: <http://purl.obolibrary.org/obo/NCBITaxon_561> (Escherichia)
+
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/NCBITaxon_561> "Escherichia")
+SubClassOf(<http://purl.obolibrary.org/obo/NCBITaxon_561> <http://purl.obolibrary.org/obo/NCBITaxon_543>)
+
+# Class: <http://purl.obolibrary.org/obo/NCBITaxon_562> (Escherichia coli)
+
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/NCBITaxon_562> "Escherichia coli")
+SubClassOf(<http://purl.obolibrary.org/obo/NCBITaxon_562> <http://purl.obolibrary.org/obo/NCBITaxon_561>)
+
 # Class: <http://purl.obolibrary.org/obo/NCBITaxon_5782> (Dictyostelium)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/NCBITaxon_5782> "Dictyostelium")
@@ -318,6 +356,11 @@ SubClassOf(<http://purl.obolibrary.org/obo/NCBITaxon_58023> <http://purl.obolibr
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/NCBITaxon_58024> "Spermatophyta")
 SubClassOf(<http://purl.obolibrary.org/obo/NCBITaxon_58024> <http://purl.obolibrary.org/obo/NCBITaxon_78536>)
 
+# Class: <http://purl.obolibrary.org/obo/NCBITaxon_637912> (Escherichia coli OP50)
+
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/NCBITaxon_637912> "Escherichia coli OP50")
+SubClassOf(<http://purl.obolibrary.org/obo/NCBITaxon_637912> <http://purl.obolibrary.org/obo/NCBITaxon_562>)
+
 # Class: <http://purl.obolibrary.org/obo/NCBITaxon_716545> (saccharomyceta)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/NCBITaxon_716545> "saccharomyceta")
@@ -328,5 +371,10 @@ SubClassOf(<http://purl.obolibrary.org/obo/NCBITaxon_716545> <http://purl.obolib
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/NCBITaxon_78536> "Euphyllophyta")
 SubClassOf(<http://purl.obolibrary.org/obo/NCBITaxon_78536> <http://purl.obolibrary.org/obo/NCBITaxon_58023>)
 
+# Class: <http://purl.obolibrary.org/obo/NCBITaxon_91347> (Enterobacterales)
+
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/NCBITaxon_91347> "Enterobacterales")
+SubClassOf(<http://purl.obolibrary.org/obo/NCBITaxon_91347> <http://purl.obolibrary.org/obo/NCBITaxon_1236>)
+
 
 )
\ No newline at end of file
diff --git a/src/ontology/imports/ncit_import.owl b/src/ontology/imports/ncit_import.owl
index b4d7920..f307fe9 100644
--- a/src/ontology/imports/ncit_import.owl
+++ b/src/ontology/imports/ncit_import.owl
@@ -7,9 +7,9 @@ Prefix(rdfs:=<http://www.w3.org/2000/01/rdf-schema#>)
 
 
 Ontology(<http://purl.obolibrary.org/obo/empty/imports/ncit_import.owl>
-<http://purl.obolibrary.org/obo/empty/releases/2026-02-23/imports/ncit_import.owl>
-Annotation(<http://purl.org/dc/elements/1.1/source> <http://purl.obolibrary.org/obo/ncit/releases/2025-08-06/ncit.owl>)
-Annotation(owl:versionInfo "2026-02-23")
+<http://purl.obolibrary.org/obo/empty/releases/2026-04-04/imports/ncit_import.owl>
+Annotation(<http://purl.org/dc/elements/1.1/source> <http://purl.obolibrary.org/obo/ncit/releases/2026-03-19/ncit.owl>)
+Annotation(owl:versionInfo "2026-04-04")
 
 Declaration(Class(<http://purl.obolibrary.org/obo/NCIT_C12219>))
 Declaration(Class(<http://purl.obolibrary.org/obo/NCIT_C14183>))
@@ -19,10 +19,15 @@ Declaration(Class(<http://purl.obolibrary.org/obo/NCIT_C142485>))
 Declaration(Class(<http://purl.obolibrary.org/obo/NCIT_C14250>))
 Declaration(Class(<http://purl.obolibrary.org/obo/NCIT_C14354>))
 Declaration(Class(<http://purl.obolibrary.org/obo/NCIT_C14376>))
+Declaration(Class(<http://purl.obolibrary.org/obo/NCIT_C16203>))
 Declaration(Class(<http://purl.obolibrary.org/obo/NCIT_C16847>))
+Declaration(Class(<http://purl.obolibrary.org/obo/NCIT_C16853>))
+Declaration(Class(<http://purl.obolibrary.org/obo/NCIT_C16856>))
 Declaration(Class(<http://purl.obolibrary.org/obo/NCIT_C17187>))
 Declaration(Class(<http://purl.obolibrary.org/obo/NCIT_C172272>))
+Declaration(Class(<http://purl.obolibrary.org/obo/NCIT_C17369>))
 Declaration(Class(<http://purl.obolibrary.org/obo/NCIT_C179817>))
+Declaration(Class(<http://purl.obolibrary.org/obo/NCIT_C17995>))
 Declaration(Class(<http://purl.obolibrary.org/obo/NCIT_C18141>))
 Declaration(Class(<http://purl.obolibrary.org/obo/NCIT_C18912>))
 Declaration(Class(<http://purl.obolibrary.org/obo/NCIT_C19160>))
@@ -37,8 +42,10 @@ Declaration(Class(<http://purl.obolibrary.org/obo/NCIT_C25167>))
 Declaration(Class(<http://purl.obolibrary.org/obo/NCIT_C25180>))
 Declaration(Class(<http://purl.obolibrary.org/obo/NCIT_C25198>))
 Declaration(Class(<http://purl.obolibrary.org/obo/NCIT_C25206>))
+Declaration(Class(<http://purl.obolibrary.org/obo/NCIT_C25218>))
 Declaration(Class(<http://purl.obolibrary.org/obo/NCIT_C25284>))
 Declaration(Class(<http://purl.obolibrary.org/obo/NCIT_C25285>))
+Declaration(Class(<http://purl.obolibrary.org/obo/NCIT_C25294>))
 Declaration(Class(<http://purl.obolibrary.org/obo/NCIT_C25335>))
 Declaration(Class(<http://purl.obolibrary.org/obo/NCIT_C25364>))
 Declaration(Class(<http://purl.obolibrary.org/obo/NCIT_C25365>))
@@ -62,6 +69,7 @@ Declaration(Class(<http://purl.obolibrary.org/obo/NCIT_C69244>))
 Declaration(Class(<http://purl.obolibrary.org/obo/NCIT_C70663>))
 Declaration(Class(<http://purl.obolibrary.org/obo/NCIT_C70766>))
 Declaration(Class(<http://purl.obolibrary.org/obo/NCIT_C73706>))
+Declaration(Class(<http://purl.obolibrary.org/obo/NCIT_C74957>))
 Declaration(Class(<http://purl.obolibrary.org/obo/NCIT_C85776>))
 Declaration(Class(<http://purl.obolibrary.org/obo/NCIT_C85845>))
 Declaration(Class(<http://purl.obolibrary.org/obo/NCIT_C88206>))
@@ -138,11 +146,27 @@ SubClassOf(<http://purl.obolibrary.org/obo/NCIT_C14354> <http://purl.obolibrary.
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/NCIT_C14376> "Other Organism Groupings")
 SubClassOf(<http://purl.obolibrary.org/obo/NCIT_C14376> <http://purl.obolibrary.org/obo/NCIT_C14250>)
 
+# Class: <http://purl.obolibrary.org/obo/NCIT_C16203> (Clinical or Research Activity)
+
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/NCIT_C16203> "Clinical or Research Activity")
+SubClassOf(<http://purl.obolibrary.org/obo/NCIT_C16203> <http://purl.obolibrary.org/obo/NCIT_C43431>)
+
 # Class: <http://purl.obolibrary.org/obo/NCIT_C16847> (Technique)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/NCIT_C16847> "Technique")
 SubClassOf(<http://purl.obolibrary.org/obo/NCIT_C16847> <http://purl.obolibrary.org/obo/NCIT_C43431>)
 
+# Class: <http://purl.obolibrary.org/obo/NCIT_C16853> (Microscopy)
+
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/NCIT_C16853> "Microscopy")
+SubClassOf(<http://purl.obolibrary.org/obo/NCIT_C16853> <http://purl.obolibrary.org/obo/NCIT_C17369>)
+SubClassOf(<http://purl.obolibrary.org/obo/NCIT_C16853> <http://purl.obolibrary.org/obo/NCIT_C74957>)
+
+# Class: <http://purl.obolibrary.org/obo/NCIT_C16856> (Fluorescence Microscopy)
+
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/NCIT_C16856> "Fluorescence Microscopy")
+SubClassOf(<http://purl.obolibrary.org/obo/NCIT_C16856> <http://purl.obolibrary.org/obo/NCIT_C17995>)
+
 # Class: <http://purl.obolibrary.org/obo/NCIT_C17187> (Technology)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/NCIT_C17187> "Technology")
@@ -153,12 +177,22 @@ SubClassOf(<http://purl.obolibrary.org/obo/NCIT_C17187> <http://purl.obolibrary.
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/NCIT_C172272> "Electronic File Content Type")
 SubClassOf(<http://purl.obolibrary.org/obo/NCIT_C172272> <http://purl.obolibrary.org/obo/NCIT_C25284>)
 
+# Class: <http://purl.obolibrary.org/obo/NCIT_C17369> (Imaging Procedure)
+
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/NCIT_C17369> "Imaging Procedure")
+SubClassOf(<http://purl.obolibrary.org/obo/NCIT_C17369> <http://purl.obolibrary.org/obo/NCIT_C25218>)
+
 # Class: <http://purl.obolibrary.org/obo/NCIT_C179817> (Velocity)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/NCIT_C179817> "Velocity")
 SubClassOf(<http://purl.obolibrary.org/obo/NCIT_C179817> <http://purl.obolibrary.org/obo/NCIT_C25447>)
 SubClassOf(<http://purl.obolibrary.org/obo/NCIT_C179817> <http://purl.obolibrary.org/obo/NCIT_C70766>)
 
+# Class: <http://purl.obolibrary.org/obo/NCIT_C17995> (Light Microscopy)
+
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/NCIT_C17995> "Light Microscopy")
+SubClassOf(<http://purl.obolibrary.org/obo/NCIT_C17995> <http://purl.obolibrary.org/obo/NCIT_C16853>)
+
 # Class: <http://purl.obolibrary.org/obo/NCIT_C18141> (Computer Sciences)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/NCIT_C18141> "Computer Sciences")
@@ -231,6 +265,11 @@ SubClassOf(<http://purl.obolibrary.org/obo/NCIT_C25198> <http://purl.obolibrary.
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/NCIT_C25206> "Temperature")
 SubClassOf(<http://purl.obolibrary.org/obo/NCIT_C25206> <http://purl.obolibrary.org/obo/NCIT_C25447>)
 
+# Class: <http://purl.obolibrary.org/obo/NCIT_C25218> (Clinical Intervention or Procedure)
+
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/NCIT_C25218> "Clinical Intervention or Procedure")
+SubClassOf(<http://purl.obolibrary.org/obo/NCIT_C25218> <http://purl.obolibrary.org/obo/NCIT_C16203>)
+
 # Class: <http://purl.obolibrary.org/obo/NCIT_C25284> (Type)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/NCIT_C25284> "Type")
@@ -241,6 +280,11 @@ SubClassOf(<http://purl.obolibrary.org/obo/NCIT_C25284> <http://purl.obolibrary.
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/NCIT_C25285> "Diameter")
 SubClassOf(<http://purl.obolibrary.org/obo/NCIT_C25285> <http://purl.obolibrary.org/obo/NCIT_C70766>)
 
+# Class: <http://purl.obolibrary.org/obo/NCIT_C25294> (Laboratory Procedure)
+
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/NCIT_C25294> "Laboratory Procedure")
+SubClassOf(<http://purl.obolibrary.org/obo/NCIT_C25294> <http://purl.obolibrary.org/obo/NCIT_C25218>)
+
 # Class: <http://purl.obolibrary.org/obo/NCIT_C25335> (Volume)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/NCIT_C25335> "Volume")
@@ -356,6 +400,11 @@ SubClassOf(<http://purl.obolibrary.org/obo/NCIT_C70766> <http://purl.obolibrary.
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/NCIT_C73706> "Spatial Qualifier")
 SubClassOf(<http://purl.obolibrary.org/obo/NCIT_C73706> <http://purl.obolibrary.org/obo/NCIT_C41009>)
 
+# Class: <http://purl.obolibrary.org/obo/NCIT_C74957> (Mixed Category Laboratory Procedure)
+
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/NCIT_C74957> "Mixed Category Laboratory Procedure")
+SubClassOf(<http://purl.obolibrary.org/obo/NCIT_C74957> <http://purl.obolibrary.org/obo/NCIT_C25294>)
+
 # Class: <http://purl.obolibrary.org/obo/NCIT_C85776> (Optical Density Measurement)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/NCIT_C85776> "Optical Density Measurement")
diff --git a/src/ontology/imports/obi_import.owl b/src/ontology/imports/obi_import.owl
index 8e99009..92f005f 100644
--- a/src/ontology/imports/obi_import.owl
+++ b/src/ontology/imports/obi_import.owl
@@ -7,9 +7,9 @@ Prefix(rdfs:=<http://www.w3.org/2000/01/rdf-schema#>)
 
 
 Ontology(<http://purl.obolibrary.org/obo/empty/imports/obi_import.owl>
-<http://purl.obolibrary.org/obo/empty/releases/2026-02-23/imports/obi_import.owl>
-Annotation(<http://purl.org/dc/elements/1.1/source> <http://purl.obolibrary.org/obo/obi/2025-12-18/obi.owl>)
-Annotation(owl:versionInfo "2026-02-23")
+<http://purl.obolibrary.org/obo/empty/releases/2026-04-04/imports/obi_import.owl>
+Annotation(<http://purl.org/dc/elements/1.1/source> <http://purl.obolibrary.org/obo/obi/2026-03-19/obi.owl>)
+Annotation(owl:versionInfo "2026-04-04")
 
 Declaration(Class(<http://purl.obolibrary.org/obo/BFO_0000015>))
 Declaration(Class(<http://purl.obolibrary.org/obo/BFO_0000017>))
@@ -142,6 +142,7 @@ Declaration(Class(<http://purl.obolibrary.org/obo/OBI_0200188>))
 Declaration(Class(<http://purl.obolibrary.org/obo/OBI_0200190>))
 Declaration(Class(<http://purl.obolibrary.org/obo/PR_000000001>))
 Declaration(Class(<http://purl.obolibrary.org/obo/PR_000018263>))
+Declaration(Class(<http://purl.obolibrary.org/obo/UBERON_0000061>))
 Declaration(Class(<http://purl.obolibrary.org/obo/UBERON_0000465>))
 Declaration(Class(<http://purl.obolibrary.org/obo/UBERON_0000466>))
 Declaration(Class(<http://purl.obolibrary.org/obo/UBERON_0000477>))
@@ -158,6 +159,7 @@ Declaration(Class(<http://purl.obolibrary.org/obo/UO_0000105>))
 Declaration(Class(<http://purl.obolibrary.org/obo/UO_0000270>))
 Declaration(Class(<http://purl.obolibrary.org/obo/UO_0000280>))
 Declaration(Class(<http://www.geneontology.org/formats/oboInOwl#ObsoleteClass>))
+Declaration(ObjectProperty(<http://purl.obolibrary.org/obo/BFO_0000050>))
 Declaration(ObjectProperty(<http://purl.obolibrary.org/obo/BFO_0000051>))
 Declaration(ObjectProperty(<http://purl.obolibrary.org/obo/BFO_0000055>))
 Declaration(ObjectProperty(<http://purl.obolibrary.org/obo/IAO_0000136>))
@@ -473,8 +475,11 @@ Declaration(AnnotationProperty(<http://www.geneontology.org/formats/oboInOwl#has
 
 # Annotation Property: <http://purl.obolibrary.org/obo/IAO_0000115> (definition)
 
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/IAO_0000115> "A property representing the English language definitions of what NCI means by the concept. They may also include information about the definition's source and attribution in a form that can easily be interpreted by software.")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/IAO_0000115> "English language definitions of what NCI means by the concept. These are limited to 1024 characters. They may also include information about the definition's source and attribution in a form that can easily be interpreted by software.")
 AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/IAO_0000115> "The official OBI definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions."@en)
 AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/IAO_0000115> "The official definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions."@en)
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/IAO_0000115> "The official definition.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/IAO_0000115> "definition")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/IAO_0000115> "definition"@en)
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/IAO_0000115> "textual definition")
@@ -494,6 +499,14 @@ AnnotationAssertion(rdfs:label <http://www.geneontology.org/formats/oboInOwl#has
 #   Object Properties
 ############################
 
+# Object Property: <http://purl.obolibrary.org/obo/BFO_0000050> (part of)
+
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/BFO_0000050> "a core relation that holds between a part and its whole"@en)
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/BFO_0000050> "part of")
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/BFO_0000050> "part of"@en)
+InverseObjectProperties(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/BFO_0000051>)
+TransitiveObjectProperty(<http://purl.obolibrary.org/obo/BFO_0000050>)
+
 # Object Property: <http://purl.obolibrary.org/obo/BFO_0000051> (has part)
 
 AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/BFO_0000051> "a core relation that holds between a whole and its part"@en)
@@ -900,7 +913,6 @@ SubClassOf(<http://purl.obolibrary.org/obo/NCBITaxon_117571> <http://purl.obolib
 
 # Class: <http://purl.obolibrary.org/obo/NCBITaxon_2759> (Eukaryota)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000118> <http://purl.obolibrary.org/obo/NCBITaxon_2759> "eucaryotes")
 AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000118> <http://purl.obolibrary.org/obo/NCBITaxon_2759> "eukaryotes")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/NCBITaxon_2759> "Eukaryota")
 SubClassOf(<http://purl.obolibrary.org/obo/NCBITaxon_2759> <http://purl.obolibrary.org/obo/COB_0000022>)
@@ -929,6 +941,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/NCBITaxon_33154> <http://purl.obolibr
 
 # Class: <http://purl.obolibrary.org/obo/NCBITaxon_33208> (Metazoa)
 
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000118> <http://purl.obolibrary.org/obo/NCBITaxon_33208> "animals")
 AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000118> <http://purl.obolibrary.org/obo/NCBITaxon_33208> "metazoans")
 AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000118> <http://purl.obolibrary.org/obo/NCBITaxon_33208> "multicellular animals")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/NCBITaxon_33208> "Metazoa")
@@ -1486,6 +1499,12 @@ AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.ob
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/PR_000018263> "amino acid chain")
 SubClassOf(<http://purl.obolibrary.org/obo/PR_000018263> <http://purl.obolibrary.org/obo/COB_0000013>)
 
+# Class: <http://purl.obolibrary.org/obo/UBERON_0000061> (anatomical structure)
+
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/UBERON_0000061> "Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome.")
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/UBERON_0000061> "anatomical structure")
+SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0000061> <http://purl.obolibrary.org/obo/UBERON_0000465>)
+
 # Class: <http://purl.obolibrary.org/obo/UBERON_0000465> (material anatomical entity)
 
 AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/UBERON_0000465> "Anatomical entity that has mass.")
@@ -1505,7 +1524,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0000466> <http://purl.obolibra
 
 AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/UBERON_0000477> "Anatomical group whose component anatomical structures lie in close proximity to each other.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/UBERON_0000477> "anatomical cluster")
-SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0000477> <http://purl.obolibrary.org/obo/BFO_0000040>)
+SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0000477> <http://purl.obolibrary.org/obo/UBERON_0000465>)
 
 # Class: <http://purl.obolibrary.org/obo/UBERON_0001062> (anatomical entity)
 
@@ -1517,7 +1536,7 @@ EquivalentClasses(<http://purl.obolibrary.org/obo/UBERON_0001062> ObjectUnionOf(
 
 AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/UBERON_0002415> "An external caudal extension of the body. In chordates, the tail is post-anal, in other animals the anus ends in the tail.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/UBERON_0002415> "tail")
-SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0002415> <http://purl.obolibrary.org/obo/UBERON_0000465>)
+SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0002415> <http://purl.obolibrary.org/obo/UBERON_0000061>)
 
 # Class: <http://purl.obolibrary.org/obo/UO_0000001> (length unit)
 
diff --git a/src/ontology/imports/omo_import.owl b/src/ontology/imports/omo_import.owl
index b17239a..9399534 100644
--- a/src/ontology/imports/omo_import.owl
+++ b/src/ontology/imports/omo_import.owl
@@ -7,9 +7,9 @@ Prefix(rdfs:=<http://www.w3.org/2000/01/rdf-schema#>)
 
 
 Ontology(<http://purl.obolibrary.org/obo/empty/imports/omo_import.owl>
-<http://purl.obolibrary.org/obo/empty/releases/2026-02-23/imports/omo_import.owl>
-Annotation(<http://purl.org/dc/elements/1.1/source> <http://purl.obolibrary.org/obo/omo/releases/2025-06-18/omo.owl>)
-Annotation(owl:versionInfo "2026-02-23")
+<http://purl.obolibrary.org/obo/empty/releases/2026-04-04/imports/omo_import.owl>
+Annotation(<http://purl.org/dc/elements/1.1/source> <http://purl.obolibrary.org/obo/omo/releases/2026-03-16/omo.owl>)
+Annotation(owl:versionInfo "2026-04-04")
 
 Declaration(Class(<http://purl.obolibrary.org/obo/IAO_0000027>))
 Declaration(Class(<http://purl.obolibrary.org/obo/IAO_0000030>))
@@ -66,9 +66,9 @@ AnnotationAssertion(rdfs:label <http://www.geneontology.org/formats/oboInOwl#has
 #   Classes
 ############################
 
-# Class: <http://purl.obolibrary.org/obo/IAO_0000027> (data item)
+# Class: <http://purl.obolibrary.org/obo/IAO_0000027> (data entity)
 
-AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/IAO_0000027> "data item"@en)
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/IAO_0000027> "data entity"@en)
 SubClassOf(<http://purl.obolibrary.org/obo/IAO_0000027> <http://purl.obolibrary.org/obo/IAO_0000030>)
 
 # Class: <http://purl.obolibrary.org/obo/IAO_0000030> (information content entity)
diff --git a/src/ontology/imports/pato_import.owl b/src/ontology/imports/pato_import.owl
index 73c1784..22aef68 100644
--- a/src/ontology/imports/pato_import.owl
+++ b/src/ontology/imports/pato_import.owl
@@ -7,9 +7,9 @@ Prefix(rdfs:=<http://www.w3.org/2000/01/rdf-schema#>)
 
 
 Ontology(<http://purl.obolibrary.org/obo/empty/imports/pato_import.owl>
-<http://purl.obolibrary.org/obo/empty/releases/2026-02-23/imports/pato_import.owl>
+<http://purl.obolibrary.org/obo/empty/releases/2026-04-04/imports/pato_import.owl>
 Annotation(<http://purl.org/dc/elements/1.1/source> <http://purl.obolibrary.org/obo/pato/releases/2025-05-14/pato.owl>)
-Annotation(owl:versionInfo "2026-02-23")
+Annotation(owl:versionInfo "2026-04-04")
 
 Declaration(Class(<http://purl.obolibrary.org/obo/BFO_0000002>))
 Declaration(Class(<http://purl.obolibrary.org/obo/BFO_0000003>))
diff --git a/src/ontology/imports/ro_import.owl b/src/ontology/imports/ro_import.owl
index 9388687..4db083e 100644
--- a/src/ontology/imports/ro_import.owl
+++ b/src/ontology/imports/ro_import.owl
@@ -7,9 +7,9 @@ Prefix(rdfs:=<http://www.w3.org/2000/01/rdf-schema#>)
 
 
 Ontology(<http://purl.obolibrary.org/obo/empty/imports/ro_import.owl>
-<http://purl.obolibrary.org/obo/empty/releases/2026-02-23/imports/ro_import.owl>
+<http://purl.obolibrary.org/obo/empty/releases/2026-04-04/imports/ro_import.owl>
 Annotation(<http://purl.org/dc/elements/1.1/source> <http://purl.obolibrary.org/obo/ro/releases/2025-12-17/ro.owl>)
-Annotation(owl:versionInfo "2026-02-23")
+Annotation(owl:versionInfo "2026-04-04")
 
 Declaration(Class(<http://purl.obolibrary.org/obo/BFO_0000002>))
 Declaration(Class(<http://purl.obolibrary.org/obo/BFO_0000003>))
diff --git a/src/ontology/imports/uberon_import.owl b/src/ontology/imports/uberon_import.owl
index 725d1e1..78a29ad 100644
--- a/src/ontology/imports/uberon_import.owl
+++ b/src/ontology/imports/uberon_import.owl
@@ -7,9 +7,9 @@ Prefix(rdfs:=<http://www.w3.org/2000/01/rdf-schema#>)
 
 
 Ontology(<http://purl.obolibrary.org/obo/empty/imports/uberon_import.owl>
-<http://purl.obolibrary.org/obo/empty/releases/2026-02-23/imports/uberon_import.owl>
-Annotation(<http://purl.org/dc/elements/1.1/source> <http://purl.obolibrary.org/obo/uberon/releases/2025-12-04/uberon.owl>)
-Annotation(owl:versionInfo "2026-02-23")
+<http://purl.obolibrary.org/obo/empty/releases/2026-04-04/imports/uberon_import.owl>
+Annotation(<http://purl.org/dc/elements/1.1/source> <http://purl.obolibrary.org/obo/uberon/releases/2026-04-01/uberon.owl>)
+Annotation(owl:versionInfo "2026-04-04")
 
 Declaration(Class(<http://purl.obolibrary.org/obo/BFO_0000001>))
 Declaration(Class(<http://purl.obolibrary.org/obo/BFO_0000002>))
@@ -39,6 +39,7 @@ Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_14321>))
 Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_15339>))
 Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_15355>))
 Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_15366>))
+Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_15378>))
 Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_15379>))
 Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_15693>))
 Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_15705>))
@@ -90,6 +91,7 @@ Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_23004>))
 Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_23019>))
 Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_23357>))
 Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_23367>))
+Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_234420>))
 Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_23449>))
 Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_23888>))
 Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_23906>))
@@ -103,6 +105,7 @@ Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_24433>))
 Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_24532>))
 Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_24533>))
 Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_24621>))
+Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_24636>))
 Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_24651>))
 Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_24663>))
 Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_24828>))
@@ -186,10 +189,12 @@ Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_33246>))
 Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_33247>))
 Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_33249>))
 Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_33250>))
+Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_33251>))
 Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_33252>))
 Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_33253>))
 Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_33256>))
 Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_33259>))
+Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_33260>))
 Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_33262>))
 Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_33263>))
 Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_33273>))
@@ -1082,7 +1087,12 @@ Declaration(Class(<http://purl.obolibrary.org/obo/CL_4052017>))
 Declaration(Class(<http://purl.obolibrary.org/obo/CL_4052030>))
 Declaration(Class(<http://purl.obolibrary.org/obo/CL_4052045>))
 Declaration(Class(<http://purl.obolibrary.org/obo/CL_4072102>))
+Declaration(Class(<http://purl.obolibrary.org/obo/COB_0000011>))
 Declaration(Class(<http://purl.obolibrary.org/obo/COB_0000013>))
+Declaration(Class(<http://purl.obolibrary.org/obo/COB_0000021>))
+Declaration(Class(<http://purl.obolibrary.org/obo/COB_0000022>))
+Declaration(Class(<http://purl.obolibrary.org/obo/COB_0000080>))
+Declaration(Class(<http://purl.obolibrary.org/obo/COB_0000502>))
 Declaration(Class(<http://purl.obolibrary.org/obo/ENVO_00000447>))
 Declaration(Class(<http://purl.obolibrary.org/obo/ENVO_01000048>))
 Declaration(Class(<http://purl.obolibrary.org/obo/GO_0000011>))
@@ -1812,6 +1822,7 @@ Declaration(Class(<http://purl.obolibrary.org/obo/GO_0010032>))
 Declaration(Class(<http://purl.obolibrary.org/obo/GO_0010034>))
 Declaration(Class(<http://purl.obolibrary.org/obo/GO_0010038>))
 Declaration(Class(<http://purl.obolibrary.org/obo/GO_0010070>))
+Declaration(Class(<http://purl.obolibrary.org/obo/GO_0010155>))
 Declaration(Class(<http://purl.obolibrary.org/obo/GO_0010160>))
 Declaration(Class(<http://purl.obolibrary.org/obo/GO_0010171>))
 Declaration(Class(<http://purl.obolibrary.org/obo/GO_0010256>))
@@ -1999,8 +2010,6 @@ Declaration(Class(<http://purl.obolibrary.org/obo/GO_0014861>))
 Declaration(Class(<http://purl.obolibrary.org/obo/GO_0014866>))
 Declaration(Class(<http://purl.obolibrary.org/obo/GO_0014872>))
 Declaration(Class(<http://purl.obolibrary.org/obo/GO_0014874>))
-Declaration(Class(<http://purl.obolibrary.org/obo/GO_0014878>))
-Declaration(Class(<http://purl.obolibrary.org/obo/GO_0014879>))
 Declaration(Class(<http://purl.obolibrary.org/obo/GO_0014887>))
 Declaration(Class(<http://purl.obolibrary.org/obo/GO_0014888>))
 Declaration(Class(<http://purl.obolibrary.org/obo/GO_0014895>))
@@ -2014,6 +2023,7 @@ Declaration(Class(<http://purl.obolibrary.org/obo/GO_0014911>))
 Declaration(Class(<http://purl.obolibrary.org/obo/GO_0014912>))
 Declaration(Class(<http://purl.obolibrary.org/obo/GO_0015031>))
 Declaration(Class(<http://purl.obolibrary.org/obo/GO_0015075>))
+Declaration(Class(<http://purl.obolibrary.org/obo/GO_0015078>))
 Declaration(Class(<http://purl.obolibrary.org/obo/GO_0015081>))
 Declaration(Class(<http://purl.obolibrary.org/obo/GO_0015106>))
 Declaration(Class(<http://purl.obolibrary.org/obo/GO_0015116>))
@@ -2893,6 +2903,7 @@ Declaration(Class(<http://purl.obolibrary.org/obo/GO_0044342>))
 Declaration(Class(<http://purl.obolibrary.org/obo/GO_0044346>))
 Declaration(Class(<http://purl.obolibrary.org/obo/GO_0044380>))
 Declaration(Class(<http://purl.obolibrary.org/obo/GO_0044419>))
+Declaration(Class(<http://purl.obolibrary.org/obo/GO_0044423>))
 Declaration(Class(<http://purl.obolibrary.org/obo/GO_0044458>))
 Declaration(Class(<http://purl.obolibrary.org/obo/GO_0044550>))
 Declaration(Class(<http://purl.obolibrary.org/obo/GO_0044565>))
@@ -3334,17 +3345,11 @@ Declaration(Class(<http://purl.obolibrary.org/obo/GO_0050931>))
 Declaration(Class(<http://purl.obolibrary.org/obo/GO_0050932>))
 Declaration(Class(<http://purl.obolibrary.org/obo/GO_0050941>))
 Declaration(Class(<http://purl.obolibrary.org/obo/GO_0050942>))
-Declaration(Class(<http://purl.obolibrary.org/obo/GO_0050952>))
 Declaration(Class(<http://purl.obolibrary.org/obo/GO_0050953>))
 Declaration(Class(<http://purl.obolibrary.org/obo/GO_0050954>))
-Declaration(Class(<http://purl.obolibrary.org/obo/GO_0050956>))
 Declaration(Class(<http://purl.obolibrary.org/obo/GO_0050962>))
-Declaration(Class(<http://purl.obolibrary.org/obo/GO_0050963>))
-Declaration(Class(<http://purl.obolibrary.org/obo/GO_0050964>))
-Declaration(Class(<http://purl.obolibrary.org/obo/GO_0050967>))
 Declaration(Class(<http://purl.obolibrary.org/obo/GO_0050968>))
 Declaration(Class(<http://purl.obolibrary.org/obo/GO_0050975>))
-Declaration(Class(<http://purl.obolibrary.org/obo/GO_0050981>))
 Declaration(Class(<http://purl.obolibrary.org/obo/GO_0050994>))
 Declaration(Class(<http://purl.obolibrary.org/obo/GO_0050995>))
 Declaration(Class(<http://purl.obolibrary.org/obo/GO_0050996>))
@@ -3424,7 +3429,6 @@ Declaration(Class(<http://purl.obolibrary.org/obo/GO_0051495>))
 Declaration(Class(<http://purl.obolibrary.org/obo/GO_0051588>))
 Declaration(Class(<http://purl.obolibrary.org/obo/GO_0051589>))
 Declaration(Class(<http://purl.obolibrary.org/obo/GO_0051590>))
-Declaration(Class(<http://purl.obolibrary.org/obo/GO_0051602>))
 Declaration(Class(<http://purl.obolibrary.org/obo/GO_0051606>))
 Declaration(Class(<http://purl.obolibrary.org/obo/GO_0051620>))
 Declaration(Class(<http://purl.obolibrary.org/obo/GO_0051621>))
@@ -4273,6 +4277,7 @@ Declaration(Class(<http://purl.obolibrary.org/obo/GO_0120006>))
 Declaration(Class(<http://purl.obolibrary.org/obo/GO_0120007>))
 Declaration(Class(<http://purl.obolibrary.org/obo/GO_0120008>))
 Declaration(Class(<http://purl.obolibrary.org/obo/GO_0120025>))
+Declaration(Class(<http://purl.obolibrary.org/obo/GO_0120029>))
 Declaration(Class(<http://purl.obolibrary.org/obo/GO_0120031>))
 Declaration(Class(<http://purl.obolibrary.org/obo/GO_0120032>))
 Declaration(Class(<http://purl.obolibrary.org/obo/GO_0120033>))
@@ -4570,6 +4575,7 @@ Declaration(Class(<http://purl.obolibrary.org/obo/GO_1902531>))
 Declaration(Class(<http://purl.obolibrary.org/obo/GO_1902532>))
 Declaration(Class(<http://purl.obolibrary.org/obo/GO_1902533>))
 Declaration(Class(<http://purl.obolibrary.org/obo/GO_1902570>))
+Declaration(Class(<http://purl.obolibrary.org/obo/GO_1902600>))
 Declaration(Class(<http://purl.obolibrary.org/obo/GO_1902679>))
 Declaration(Class(<http://purl.obolibrary.org/obo/GO_1902680>))
 Declaration(Class(<http://purl.obolibrary.org/obo/GO_1902692>))
@@ -5636,7 +5642,7 @@ Declaration(Class(<http://purl.obolibrary.org/obo/PR_Q9Y6Q6>))
 Declaration(Class(<http://purl.obolibrary.org/obo/RO_0002577>))
 Declaration(Class(<http://purl.obolibrary.org/obo/SO_0000253>))
 Declaration(Class(<http://purl.obolibrary.org/obo/SO_0001217>))
-Declaration(Class(<http://purl.obolibrary.org/obo/UBERON_0000000>))
+Declaration(Class(<http://purl.obolibrary.org/obo/UBERON_0000001>))
 Declaration(Class(<http://purl.obolibrary.org/obo/UBERON_0000005>))
 Declaration(Class(<http://purl.obolibrary.org/obo/UBERON_0000006>))
 Declaration(Class(<http://purl.obolibrary.org/obo/UBERON_0000009>))
@@ -7107,7 +7113,6 @@ Declaration(Class(<http://purl.obolibrary.org/obo/UBERON_0007592>))
 Declaration(Class(<http://purl.obolibrary.org/obo/UBERON_0007601>))
 Declaration(Class(<http://purl.obolibrary.org/obo/UBERON_0007616>))
 Declaration(Class(<http://purl.obolibrary.org/obo/UBERON_0007617>))
-Declaration(Class(<http://purl.obolibrary.org/obo/UBERON_0007625>))
 Declaration(Class(<http://purl.obolibrary.org/obo/UBERON_0007635>))
 Declaration(Class(<http://purl.obolibrary.org/obo/UBERON_0007641>))
 Declaration(Class(<http://purl.obolibrary.org/obo/UBERON_0007645>))
@@ -7359,7 +7364,6 @@ Declaration(Class(<http://purl.obolibrary.org/obo/UBERON_0010427>))
 Declaration(Class(<http://purl.obolibrary.org/obo/UBERON_0010428>))
 Declaration(Class(<http://purl.obolibrary.org/obo/UBERON_0010498>))
 Declaration(Class(<http://purl.obolibrary.org/obo/UBERON_0010499>))
-Declaration(Class(<http://purl.obolibrary.org/obo/UBERON_0010521>))
 Declaration(Class(<http://purl.obolibrary.org/obo/UBERON_0010522>))
 Declaration(Class(<http://purl.obolibrary.org/obo/UBERON_0010523>))
 Declaration(Class(<http://purl.obolibrary.org/obo/UBERON_0010527>))
@@ -7873,6 +7877,7 @@ Declaration(Class(<http://purl.obolibrary.org/obo/UBERON_8600123>))
 Declaration(Class(<http://purl.obolibrary.org/obo/UBERON_8600136>))
 Declaration(Class(<http://purl.obolibrary.org/obo/UBERON_8600138>))
 Declaration(Class(<http://purl.obolibrary.org/obo/UBERON_8600140>))
+Declaration(Class(<http://purl.obolibrary.org/obo/UBERON_8850001>))
 Declaration(ObjectProperty(<http://purl.obolibrary.org/obo/BFO_0000050>))
 Declaration(ObjectProperty(<http://purl.obolibrary.org/obo/BFO_0000051>))
 Declaration(ObjectProperty(<http://purl.obolibrary.org/obo/BFO_0000062>))
@@ -8084,19 +8089,20 @@ Declaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0015011>))
 Declaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0015015>))
 Declaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0015016>))
 Declaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0017001>))
+Declaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0018030>))
+Declaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0018033>))
+Declaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0018034>))
+Declaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0018036>))
+Declaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0018037>))
+Declaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0018038>))
+Declaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0018039>))
+Declaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0018040>))
 Declaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0020101>))
 Declaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0020102>))
 Declaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0020104>))
 Declaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0020105>))
 Declaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0020337>))
 Declaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0040036>))
-Declaration(ObjectProperty(<http://purl.obolibrary.org/obo/chebi#has_functional_parent>))
-Declaration(ObjectProperty(<http://purl.obolibrary.org/obo/chebi#has_parent_hydride>))
-Declaration(ObjectProperty(<http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of>))
-Declaration(ObjectProperty(<http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of>))
-Declaration(ObjectProperty(<http://purl.obolibrary.org/obo/chebi#is_enantiomer_of>))
-Declaration(ObjectProperty(<http://purl.obolibrary.org/obo/chebi#is_substituent_group_from>))
-Declaration(ObjectProperty(<http://purl.obolibrary.org/obo/chebi#is_tautomer_of>))
 Declaration(ObjectProperty(<http://purl.obolibrary.org/obo/pr#has_gene_template>))
 Declaration(ObjectProperty(<http://purl.obolibrary.org/obo/uberon/core#anteriorly_connected_to>))
 Declaration(ObjectProperty(<http://purl.obolibrary.org/obo/uberon/core#channel_for>))
@@ -8790,6 +8796,7 @@ TransitiveObjectProperty(<http://purl.obolibrary.org/obo/RO_0002213>)
 
 # Object Property: <http://purl.obolibrary.org/obo/RO_0002215> (capable of)
 
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/RO_0002215> "A relation between a material entity (such as a cell) and a process, in which the material entity has the ability to carry out the process.")
 AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/RO_0002215> "A relation between a material entity (such as a cell) and a process, in which the material entity has the ability to carry out the process. ")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/RO_0002215> "capable of")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/RO_0002215> "capable of"@en)
@@ -9697,6 +9704,69 @@ ObjectPropertyDomain(<http://purl.obolibrary.org/obo/RO_0015016> <http://purl.ob
 AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/RO_0017001> "X device utilizes material Y means X and Y are material entities, and X is capable of some process P that has input Y.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/RO_0017001> "device utilizes material"@en)
 
+# Object Property: <http://purl.obolibrary.org/obo/RO_0018030> (chemical relationship)
+
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/RO_0018030> "chemical relationship")
+
+# Object Property: <http://purl.obolibrary.org/obo/RO_0018033> (is deprotonated form of)
+
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/RO_0018033> "A is a deprotonated form of B if and only if A is chemical entity that is a Brønsted–Lowry Base (i.e., can receive a proton) and by adding some nonzero number of protons transforms it into B.
+
+This is a transitive relationship and follows this design pattern: https://oborel.github.io/obo-relations/direct-and-indirect-relations.")
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/RO_0018033> "is deprotonated form of")
+SubObjectPropertyOf(<http://purl.obolibrary.org/obo/RO_0018033> <http://purl.obolibrary.org/obo/RO_0018030>)
+InverseObjectProperties(<http://purl.obolibrary.org/obo/RO_0018033> <http://purl.obolibrary.org/obo/RO_0018034>)
+TransitiveObjectProperty(<http://purl.obolibrary.org/obo/RO_0018033>)
+
+# Object Property: <http://purl.obolibrary.org/obo/RO_0018034> (is protonated form of)
+
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/RO_0018034> "A is a protonated form of B if and only if A is chemical entity that is a Brønsted–Lowry Acid (i.e., can give up a proton) and by removing some nonzero number of protons transforms it into B.
+
+This is a transitive relationship and follows this design pattern: https://oborel.github.io/obo-relations/direct-and-indirect-relations.")
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/RO_0018034> "is protonated form of")
+SubObjectPropertyOf(<http://purl.obolibrary.org/obo/RO_0018034> <http://purl.obolibrary.org/obo/RO_0018030>)
+TransitiveObjectProperty(<http://purl.obolibrary.org/obo/RO_0018034>)
+
+# Object Property: <http://purl.obolibrary.org/obo/RO_0018036> (is tautomer of)
+
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/RO_0018036> "Two chemicals are tautomers if they can be readily interconverted.
+
+This commonly refers to prototropy in which a hydrogen's position is changed, such as between ketones and enols. This is also often observed in heterocyclic rings, e.g., ones containing nitrogens and/or have aryl functional groups containing heteroatoms.")
+AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasExactSynonym> <http://purl.obolibrary.org/obo/RO_0018036> "is desmotrope of")
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/RO_0018036> "is tautomer of"@en)
+SubObjectPropertyOf(<http://purl.obolibrary.org/obo/RO_0018036> <http://purl.obolibrary.org/obo/RO_0018030>)
+SymmetricObjectProperty(<http://purl.obolibrary.org/obo/RO_0018036>)
+
+# Object Property: <http://purl.obolibrary.org/obo/RO_0018037> (is substitutent group from)
+
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/RO_0018037> "Group A is a substituent group from Chemical B if A represents the functional part of A and includes information about where it is connected. A is not itself a chemical with a fully formed chemical graph, but is rather a partial graph with one or more connection points that can be used to attach to another chemical graph, typically as a functionalization.")
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/RO_0018037> "is substitutent group from"@en)
+SubObjectPropertyOf(<http://purl.obolibrary.org/obo/RO_0018037> <http://purl.obolibrary.org/obo/RO_0018030>)
+
+# Object Property: <http://purl.obolibrary.org/obo/RO_0018038> (has functional parent)
+
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/RO_0018038> "Chemical A has functional parent Chemical B if there is chemical transformation through which chemical B can be produced from chemical A. 
+
+For example, the relationship between a salt and a freebased compound is a \"has functional parent\" relationship.")
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/RO_0018038> "has functional parent"@en)
+SubObjectPropertyOf(<http://purl.obolibrary.org/obo/RO_0018038> <http://purl.obolibrary.org/obo/RO_0018030>)
+
+# Object Property: <http://purl.obolibrary.org/obo/RO_0018039> (is enantiomer of)
+
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/RO_0018039> "Chemicals A and B are enantiomers if they share the same molecular graph except the change of the configuration of substituents around exactly one chiral center.
+
+A chemical with no chiral centers can not have an enantiomer. A chemical with multiple chiral centers can have multiple enantiomers, but its enantiomers are not themselves enantiomers (they are diastereomers).")
+AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasExactSynonym> <http://purl.obolibrary.org/obo/RO_0018039> "is optical isomer of")
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/RO_0018039> "is enantiomer of"@en)
+SubObjectPropertyOf(<http://purl.obolibrary.org/obo/RO_0018039> <http://purl.obolibrary.org/obo/RO_0018030>)
+SymmetricObjectProperty(<http://purl.obolibrary.org/obo/RO_0018039>)
+
+# Object Property: <http://purl.obolibrary.org/obo/RO_0018040> (has parent hydride)
+
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/RO_0018040> "Chemical A has parent hydride Chemical B if there exists a molecular graphical transformation where functional groups on A are replaced with hydrogens in order to yield B.")
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/RO_0018040> "has parent hydride"@en)
+SubObjectPropertyOf(<http://purl.obolibrary.org/obo/RO_0018040> <http://purl.obolibrary.org/obo/RO_0018030>)
+
 # Object Property: <http://purl.obolibrary.org/obo/RO_0020101> (vessel supplies blood to)
 
 AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/RO_0020101> "x vessel supplies blood to y if and only if x is a vessel that supplies blood directly or indirectly to an anatomical structure y.")
@@ -9809,6 +9879,7 @@ AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/uberon/core#site_
 # Object Property: <http://purl.obolibrary.org/obo/uberon/core#subdivision_of> (subdivision of)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/uberon/core#subdivision_of> "subdivision of")
+SubObjectPropertyOf(<http://purl.obolibrary.org/obo/uberon/core#subdivision_of> <http://purl.obolibrary.org/obo/BFO_0000050>)
 
 # Object Property: <http://purl.obolibrary.org/obo/uberon/core#transitively_anteriorly_connected_to> (transitively anteriorly connected to)
 
@@ -9871,6 +9942,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/BFO_0000015> <http://purl.obolibrary.
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/BFO_0000017> "realizable entity"@en)
 SubClassOf(<http://purl.obolibrary.org/obo/BFO_0000017> <http://purl.obolibrary.org/obo/BFO_0000020>)
+SubClassOf(<http://purl.obolibrary.org/obo/BFO_0000017> <http://purl.obolibrary.org/obo/COB_0000502>)
 SubClassOf(<http://purl.obolibrary.org/obo/BFO_0000017> ObjectAllValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/BFO_0000017>))
 DisjointClasses(<http://purl.obolibrary.org/obo/BFO_0000017> <http://purl.obolibrary.org/obo/BFO_0000019>)
 
@@ -9911,12 +9983,13 @@ AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CARO_0000000> "an
 # Class: <http://purl.obolibrary.org/obo/CHEBI_10545> (electron)
 
 AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_10545> "Elementary particle not affected by the strong force having a spin 1/2, a negative elementary charge and a rest mass of 0.000548579903(13) u, or 0.51099906(15) MeV.")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_10545> "Elementary particle not affected by the strong force having a spin ½, a negative elementary charge and a rest mass of 0.000548579903(13) u, or 0.51099906(15) MeV.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_10545> "electron")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_10545> <http://purl.obolibrary.org/obo/CHEBI_36338>)
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_131604> (Mycoplasma genitalium metabolite)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_131604> "Any bacterial metabolite produced during a metabolic reaction in Mycoplasma genitalium.")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_131604> "Any bacterial metabolite produced during a metabolic reaction in <em>Mycoplasma genitalium</em>.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_131604> "Mycoplasma genitalium metabolite")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_131604> <http://purl.obolibrary.org/obo/CHEBI_76969>)
 
@@ -9932,23 +10005,23 @@ AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.ob
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_132153> "hyaluronate")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_132153> <http://purl.obolibrary.org/obo/CHEBI_61469>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_132153> <http://purl.obolibrary.org/obo/CHEBI_63551>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_132153> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of> <http://purl.obolibrary.org/obo/CHEBI_16336>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_132153> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018033> <http://purl.obolibrary.org/obo/CHEBI_16336>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_136889> (5beta steroid)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_136889> "Any steroid that has beta-configuration at position 5.")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_136889> "Any steroid that has β-configuration at position 5.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_136889> "5beta steroid")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_136889> <http://purl.obolibrary.org/obo/CHEBI_35341>)
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_138103> (inorganic acid)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_138103> "A Bronsted acid derived from one or more inorganic compounds. Inorganic acids (also known as mineral acids) form hydrons and conjugate base ions when dissolved in water.")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_138103> "A Brønsted acid derived from one or more inorganic compounds. Inorganic acids (also known as mineral acids) form hydrons and conjugate base ions when dissolved in water.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_138103> "inorganic acid")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_138103> <http://purl.obolibrary.org/obo/CHEBI_39141>)
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_138366> (bile acids)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_138366> "Any member of a group of hydroxy steroids occuring in bile, where they are present as the sodium salts of their amides with glycine or taurine. In mammals bile acids almost invariably have 5beta-configuration, while in lower vertebrates, some bile acids, known as allo-bile acids, have 5alpha-configuration.")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_138366> "Any member of a group of hydroxy steroids occuring in bile, where they are present as the sodium salts of their amides with glycine or taurine. In mammals bile acids almost invariably have 5β-configuration, while in lower vertebrates, some bile acids, known as <i>allo</i>-bile acids, have 5α-configuration.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_138366> "bile acids")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_138366> <http://purl.obolibrary.org/obo/CHEBI_25384>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_138366> <http://purl.obolibrary.org/obo/CHEBI_35350>)
@@ -9956,7 +10029,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_138366> <http://purl.obolibrary
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_138675> (gas molecular entity)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_138675> "Any main group molecular entity that is gaseous at standard temperature and pressure (STP; 0degreeC and 100 kPa).")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_138675> "Any main group molecular entity that is gaseous at standard temperature and pressure (STP; 0°C and 100 kPa).")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_138675> "gas molecular entity")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_138675> <http://purl.obolibrary.org/obo/CHEBI_33579>)
 
@@ -9964,18 +10037,18 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_138675> <http://purl.obolibrary
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_13941> "carbamate")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_13941> <http://purl.obolibrary.org/obo/CHEBI_37022>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_13941> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of> <http://purl.obolibrary.org/obo/CHEBI_28616>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_13941> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018033> <http://purl.obolibrary.org/obo/CHEBI_28616>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_140601> (fatty acid 4:0)
 
 AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_140601> "Any saturated fatty acid containing 4 carbons.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_140601> "fatty acid 4:0")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_140601> <http://purl.obolibrary.org/obo/CHEBI_26666>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_140601> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of> <http://purl.obolibrary.org/obo/CHEBI_78115>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_140601> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018034> <http://purl.obolibrary.org/obo/CHEBI_78115>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_142163> (24G7 epitope)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_142163> "An antigenic epitope recognized by an anti-bilirubin monoclonal antibody designated 24G7. A substructure of bilirubin IXalpha, it is the region containing the oxo group at C-1, the methyl group at C-2, C-(4, 5, 6, 9), and N-21 and -22.")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_142163> "An antigenic epitope recognized by an anti-bilirubin monoclonal antibody designated 24G7. A substructure of bilirubin IXα, it is the region containing the oxo group at C-1, the methyl group at C-2, C-(4, 5, 6, 9), and N-21 and -22.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_142163> "24G7 epitope")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_142163> <http://purl.obolibrary.org/obo/BFO_0000004>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_142163> <http://purl.obolibrary.org/obo/CHEBI_24433>)
@@ -9983,13 +10056,13 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_142163> ObjectSomeValuesFrom(<h
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_14321> (glutamate(1-))
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_14321> "An alpha-amino-acid anion that is the conjugate base of glutamic acid, having anionic carboxy groups and a cationic amino group")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_14321> "An α-amino-acid anion that is the conjugate base of glutamic acid, having anionic carboxy groups and a cationic amino group")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_14321> "glutamate(1-)")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_14321> <http://purl.obolibrary.org/obo/BFO_0000004>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_14321> <http://purl.obolibrary.org/obo/CHEBI_33558>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_14321> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_78675>))
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_14321> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of> <http://purl.obolibrary.org/obo/CHEBI_29987>))
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_14321> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of> <http://purl.obolibrary.org/obo/CHEBI_18237>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_14321> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018033> <http://purl.obolibrary.org/obo/CHEBI_18237>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_14321> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018034> <http://purl.obolibrary.org/obo/CHEBI_29987>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_15339> (acceptor)
 
@@ -10020,7 +10093,16 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_15366> ObjectSomeValuesFrom(<ht
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_15366> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_64049>))
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_15366> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_65256>))
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_15366> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_83056>))
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_15366> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of> <http://purl.obolibrary.org/obo/CHEBI_30089>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_15366> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018034> <http://purl.obolibrary.org/obo/CHEBI_30089>))
+
+# Class: <http://purl.obolibrary.org/obo/CHEBI_15378> (hydron)
+
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_15378> "The general name for the hydrogen nucleus, to be used without regard to the hydrogen nuclear mass (either for hydrogen in its natural abundance or where it is not desired to distinguish between the isotopes).")
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_15378> "hydron")
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_15378> <http://purl.obolibrary.org/obo/CHEBI_25414>)
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_15378> <http://purl.obolibrary.org/obo/CHEBI_33251>)
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_15378> <http://purl.obolibrary.org/obo/CHEBI_33252>)
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_15378> <http://purl.obolibrary.org/obo/CHEBI_60242>)
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_15379> (dioxygen)
 
@@ -10037,21 +10119,21 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_15379> ObjectSomeValuesFrom(<ht
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_15379> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_75772>))
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_15379> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_77746>))
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_15379> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_77974>))
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_15379> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of> <http://purl.obolibrary.org/obo/CHEBI_29793>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_15379> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018033> <http://purl.obolibrary.org/obo/CHEBI_29793>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_15693> (aldose)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_15693> "Aldehydic parent sugars (polyhydroxy aldehydes H[CH(OH)]nC(=O)H, n >= 2) and their intramolecular hemiacetals.")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_15693> "Aldehydic parent sugars (polyhydroxy aldehydes H[CH(OH)]<small><sub><em>n</em></sub></small>C(=O)H, <em>n</em> ≥ 2) and their intramolecular hemiacetals.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_15693> "aldose")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_15693> <http://purl.obolibrary.org/obo/CHEBI_35381>)
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_15705> (L-alpha-amino acid)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_15705> "Any alpha-amino acid having L-configuration at the alpha-carbon.")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_15705> "Any α-amino acid having <small>L</small>-configuration at the α-carbon.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_15705> "L-alpha-amino acid")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_15705> <http://purl.obolibrary.org/obo/CHEBI_33704>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_15705> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of> <http://purl.obolibrary.org/obo/CHEBI_59814>))
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_15705> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_tautomer_of> <http://purl.obolibrary.org/obo/CHEBI_59869>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_15705> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018034> <http://purl.obolibrary.org/obo/CHEBI_59814>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_15705> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018036> <http://purl.obolibrary.org/obo/CHEBI_59869>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_15841> (polypeptide)
 
@@ -10062,14 +10144,14 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_15841> <http://purl.obolibrary.
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_15966> (D-glutamic acid)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_15966> "An optically active form of glutamic acid having D-configuration.")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_15966> "An optically active form of glutamic acid having <small>D</small>-configuration.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_15966> "D-glutamic acid")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_15966> <http://purl.obolibrary.org/obo/CHEBI_16733>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_15966> <http://purl.obolibrary.org/obo/CHEBI_18237>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_15966> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_75771>))
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_15966> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_76971>))
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_15966> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of> <http://purl.obolibrary.org/obo/CHEBI_29986>))
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_15966> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_enantiomer_of> <http://purl.obolibrary.org/obo/CHEBI_16015>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_15966> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018034> <http://purl.obolibrary.org/obo/CHEBI_29986>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_15966> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018039> <http://purl.obolibrary.org/obo/CHEBI_16015>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_15986> (polynucleotide)
 
@@ -10081,7 +10163,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_15986> ObjectSomeValuesFrom(<ht
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_16015> (L-glutamic acid)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_16015> "An optically active form of glutamic acid having L-configuration.")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_16015> "An optically active form of glutamic acid having <small>L</small>-configuration.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_16015> "L-glutamic acid")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_16015> <http://purl.obolibrary.org/obo/CHEBI_18237>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_16015> <http://purl.obolibrary.org/obo/CHEBI_24318>)
@@ -10091,8 +10173,8 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_16015> ObjectSomeValuesFrom(<ht
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_16015> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_50733>))
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_16015> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_75771>))
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_16015> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_76971>))
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_16015> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of> <http://purl.obolibrary.org/obo/CHEBI_29985>))
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_16015> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_enantiomer_of> <http://purl.obolibrary.org/obo/CHEBI_15966>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_16015> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018034> <http://purl.obolibrary.org/obo/CHEBI_29985>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_16015> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018039> <http://purl.obolibrary.org/obo/CHEBI_15966>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_16134> (ammonia)
 
@@ -10109,8 +10191,8 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_16134> ObjectSomeValuesFrom(<ht
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_16134> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_75771>))
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_16134> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_77941>))
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_16134> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_78433>))
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_16134> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of> <http://purl.obolibrary.org/obo/CHEBI_29337>))
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_16134> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of> <http://purl.obolibrary.org/obo/CHEBI_28938>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_16134> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018033> <http://purl.obolibrary.org/obo/CHEBI_28938>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_16134> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018034> <http://purl.obolibrary.org/obo/CHEBI_29337>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_16189> (sulfate)
 
@@ -10123,17 +10205,17 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_16189> <http://purl.obolibrary.
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_16189> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_23357>))
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_16189> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_75772>))
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_16189> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_77746>))
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_16189> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of> <http://purl.obolibrary.org/obo/CHEBI_45696>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_16189> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018033> <http://purl.obolibrary.org/obo/CHEBI_45696>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_16336> (hyaluronic acid)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_16336> "A mucopolysaccharide composed of N-acetylglucosamine and glucuronic acid subunits. It is found in the connective tissues of vertebrates. A principal constituent of the extracellular matrix (ECM), it mediates the growth and metastasis of tumour cells.")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_16336> "A mucopolysaccharide composed of <em>N</em>-acetylglucosamine and glucuronic acid subunits. It is found in the connective tissues of vertebrates. A principal constituent of the extracellular matrix (ECM), it mediates the growth and metastasis of tumour cells.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_16336> "hyaluronic acid")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_16336> <http://purl.obolibrary.org/obo/BFO_0000004>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_16336> <http://purl.obolibrary.org/obo/CHEBI_37395>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_16336> <http://purl.obolibrary.org/obo/CHEBI_72813>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_16336> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_77746>))
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_16336> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of> <http://purl.obolibrary.org/obo/CHEBI_132153>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_16336> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018034> <http://purl.obolibrary.org/obo/CHEBI_132153>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_16541> (protein polypeptide chain)
 
@@ -10144,36 +10226,37 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_16541> ObjectSomeValuesFrom(<ht
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_16646> (carbohydrate)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_16646> "Any member of the class of organooxygen compounds that is a polyhydroxy-aldehyde or -ketone or a lactol resulting from their intramolecular condensation (monosaccharides); substances derived from these by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom; and polymeric products arising by intermolecular acetal formation between two or more such molecules (disaccharides, polysaccharides and oligosaccharides). Carbohydrates contain only carbon, hydrogen and oxygen atoms; prior to any oxidation or reduction, most have the empirical formula Cm(H2O)n. Compounds obtained from carbohydrates by substitution, etc., are known as carbohydrate derivatives and may contain other elements. Cyclitols are generally not regarded as carbohydrates.")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_16646> "Any member of the class of organooxygen compounds that is a polyhydroxy-aldehyde or -ketone or a lactol resulting from their intramolecular condensation (monosaccharides); substances derived from these by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom; and polymeric products arising by intermolecular acetal formation between two or more such molecules (disaccharides, polysaccharides and oligosaccharides). Carbohydrates contain only carbon, hydrogen and oxygen atoms; prior to any oxidation or reduction, most have the empirical formula C<small><sub><em>m</em></sub></small>(H<small><sub>2</sub></small>O)<small><sub><em>n</em></sub></small>. Compounds obtained from carbohydrates by substitution, etc., are known as carbohydrate derivatives and may contain other elements. Cyclitols are generally not regarded as carbohydrates.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_16646> "carbohydrate")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_16646> <http://purl.obolibrary.org/obo/CHEBI_78616>)
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_16670> (peptide)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_16670> "Amide derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen atom of another with formal loss of water. The term is usually applied to structures formed from alpha-amino acids, but it includes those derived from any amino carboxylic acid. X = OH, OR, NH2, NHR, etc.")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_16670> "Amide derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen atom of another with formal loss of water. The term is usually applied to structures formed from α-amino acids, but it includes those derived from any amino carboxylic acid. X = OH, OR, NH2, NHR, etc.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_16670> "peptide")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_16670> <http://purl.obolibrary.org/obo/CHEBI_37622>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_16670> <http://purl.obolibrary.org/obo/CHEBI_50047>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_16670> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> <http://purl.obolibrary.org/obo/CHEBI_33708>))
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_16670> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_tautomer_of> <http://purl.obolibrary.org/obo/CHEBI_60466>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_16670> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018036> <http://purl.obolibrary.org/obo/CHEBI_60466>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_166902> (noradrenaline(1+))
 
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_166902> "An organic cation that is the conjugate acid of noradrenaline, obtained by protonation of the primary amino group; major species at pH 7.3.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_166902> "noradrenaline(1+)")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_166902> <http://purl.obolibrary.org/obo/CHEBI_25697>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_166902> <http://purl.obolibrary.org/obo/CHEBI_35274>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_166902> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of> <http://purl.obolibrary.org/obo/CHEBI_33569>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_166902> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018034> <http://purl.obolibrary.org/obo/CHEBI_33569>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_16733> (D-alpha-amino acid)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_16733> "D-alpha-amino acid")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_16733> <http://purl.obolibrary.org/obo/CHEBI_83925>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_16733> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of> <http://purl.obolibrary.org/obo/CHEBI_60895>))
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_16733> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_tautomer_of> <http://purl.obolibrary.org/obo/CHEBI_59871>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_16733> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018034> <http://purl.obolibrary.org/obo/CHEBI_60895>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_16733> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018036> <http://purl.obolibrary.org/obo/CHEBI_59871>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_167559> (glycan)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_167559> "Any oligosaccharide, polysaccharide or their derivatives consisting of monosaccharides or monosaccharide derivatives linked by glycosidic bonds. See also http://www.ontobee.org/ontology/GNO?iri=http://purl.obolibrary.org/obo/GNO_00000001.")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_167559> "Any oligosaccharide, polysaccharide or their derivatives consisting of monosaccharides or monosaccharide derivatives linked by glycosidic bonds. See also <a href=\"http://www.ontobee.org/ontology/GNO?iri=http://purl.obolibrary.org/obo/GNO_00000001\" target=\"_blank\">http://www.ontobee.org/ontology/GNO?iri=http://purl.obolibrary.org/obo/GNO_00000001</a>.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_167559> "glycan")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_167559> <http://purl.obolibrary.org/obo/CHEBI_78616>)
 
@@ -10188,11 +10271,11 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_16765> <http://purl.obolibrary.
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_16765> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_75771>))
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_16765> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_76924>))
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_16765> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_77746>))
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_16765> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of> <http://purl.obolibrary.org/obo/CHEBI_57887>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_16765> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018033> <http://purl.obolibrary.org/obo/CHEBI_57887>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_16865> (gamma-aminobutyric acid)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_16865> "A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_16865> "A γ-amino acid that is butanoic acid with the amino substituent located at C-4.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_16865> "gamma-aminobutyric acid")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_16865> <http://purl.obolibrary.org/obo/CHEBI_25384>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_16865> <http://purl.obolibrary.org/obo/CHEBI_33707>)
@@ -10200,9 +10283,9 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_16865> ObjectSomeValuesFrom(<ht
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_16865> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_62488>))
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_16865> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_75772>))
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_16865> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_77746>))
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_16865> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#has_functional_parent> <http://purl.obolibrary.org/obo/CHEBI_30772>))
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_16865> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of> <http://purl.obolibrary.org/obo/CHEBI_30566>))
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_16865> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_tautomer_of> <http://purl.obolibrary.org/obo/CHEBI_59888>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_16865> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018034> <http://purl.obolibrary.org/obo/CHEBI_30566>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_16865> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018036> <http://purl.obolibrary.org/obo/CHEBI_59888>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_16865> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018038> <http://purl.obolibrary.org/obo/CHEBI_30772>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_16990> (bilirubin IXalpha)
 
@@ -10214,11 +10297,11 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_16990> ObjectSomeValuesFrom(<ht
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_16990> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_22586>))
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_16990> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_75771>))
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_16990> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_77746>))
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_16990> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of> <http://purl.obolibrary.org/obo/CHEBI_57977>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_16990> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018034> <http://purl.obolibrary.org/obo/CHEBI_57977>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_17087> (ketone)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_17087> "A compound in which a carbonyl group is bonded to two carbon atoms: R2C=O (neither R may be H).")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_17087> "A compound in which a carbonyl group is bonded to two carbon atoms: R<small><sub>2</sub></small>C=O (neither R may be H).")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_17087> "ketone")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_17087> <http://purl.obolibrary.org/obo/CHEBI_36586>)
 
@@ -10254,19 +10337,19 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_17544> ObjectSomeValuesFrom(<ht
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_17544> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_75772>))
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_17544> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_76971>))
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_17544> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_77746>))
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_17544> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of> <http://purl.obolibrary.org/obo/CHEBI_41609>))
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_17544> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of> <http://purl.obolibrary.org/obo/CHEBI_28976>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_17544> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018033> <http://purl.obolibrary.org/obo/CHEBI_28976>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_17544> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018034> <http://purl.obolibrary.org/obo/CHEBI_41609>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_17608> (D-aldohexose)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_17608> "Any D-aldose having a chain of six carbon atoms in the molecule.")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_17608> "Any <small>D</small>-aldose having a chain of six carbon atoms in the molecule.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_17608> "D-aldohexose")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_17608> <http://purl.obolibrary.org/obo/CHEBI_33917>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_17608> <http://purl.obolibrary.org/obo/CHEBI_4194>)
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_17634> (D-glucose)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_17634> "A glucose with D-configuration.")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_17634> "A glucose with <small>D</small>-configuration.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_17634> "D-glucose")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_17634> <http://purl.obolibrary.org/obo/CHEBI_17234>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_17634> <http://purl.obolibrary.org/obo/CHEBI_17608>)
@@ -10292,7 +10375,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_17968> <http://purl.obolibrary.
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_17968> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_25212>))
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_17968> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_61115>))
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_17968> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_77746>))
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_17968> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of> <http://purl.obolibrary.org/obo/CHEBI_30772>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_17968> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018033> <http://purl.obolibrary.org/obo/CHEBI_30772>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_18059> (lipid)
 
@@ -10322,13 +10405,13 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_18154> <http://purl.obolibrary.
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_18237> (glutamic acid)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_18237> "An alpha-amino acid that is glutaric acid bearing a single amino substituent at position 2.")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_18237> "An α-amino acid that is glutaric acid bearing a single amino substituent at position 2.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_18237> "glutamic acid")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_18237> <http://purl.obolibrary.org/obo/CHEBI_26167>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_18237> <http://purl.obolibrary.org/obo/CHEBI_33704>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_18237> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> <http://purl.obolibrary.org/obo/CHEBI_50329>))
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_18237> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_78675>))
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_18237> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of> <http://purl.obolibrary.org/obo/CHEBI_14321>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_18237> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018034> <http://purl.obolibrary.org/obo/CHEBI_14321>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_18282> (nucleobase)
 
@@ -10338,7 +10421,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_18282> <http://purl.obolibrary.
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_18357> ((R)-noradrenaline)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_18357> "The R-enantiomer of noradrenaline.")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_18357> "The <i>R</i>-enantiomer of noradrenaline.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_18357> "(R)-noradrenaline")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_18357> <http://purl.obolibrary.org/obo/CHEBI_33569>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_18357> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_25512>))
@@ -10346,8 +10429,8 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_18357> ObjectSomeValuesFrom(<ht
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_18357> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_35569>))
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_18357> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_50514>))
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_18357> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_75771>))
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_18357> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of> <http://purl.obolibrary.org/obo/CHEBI_72587>))
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_18357> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_enantiomer_of> <http://purl.obolibrary.org/obo/CHEBI_33571>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_18357> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018033> <http://purl.obolibrary.org/obo/CHEBI_72587>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_18357> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018039> <http://purl.obolibrary.org/obo/CHEBI_33571>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_20664> (5beta-cholane)
 
@@ -10356,7 +10439,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_20664> <http://purl.obolibrary.
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_22221> (acyl group)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_22221> "An organic group formed by removing one or more hydroxy groups from an oxoacid that has the general structure RkE(=O)l(OH)m (l =/= 0). Although the term is almost always applied to organic compounds, with carboxylic acid as the oxoacid, acyl groups can in principle be derived from other types of acids such as sulfonic acids or phosphonic acids.")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_22221> "An organic group formed by removing one or more hydroxy groups from an oxoacid that has the general structure R<small><sub><em>k</em></sub></small>E(=O)<small><sub><em>l</em></sub></small>(OH)<small><sub><em>m</em></sub></small> (<em>l</em> ≠ 0). Although the term is almost always applied to organic compounds, with carboxylic acid as the oxoacid, acyl groups can in principle be derived from other types of acids such as sulfonic acids or phosphonic acids.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_22221> "acyl group")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_22221> <http://purl.obolibrary.org/obo/CHEBI_33247>)
 
@@ -10395,7 +10478,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_22586> <http://purl.obolibrary.
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_22695> (base)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_22695> "A molecular entity having an available pair of electrons capable of forming a covalent bond with a hydron (Bronsted base) or with the vacant orbital of some other molecular entity (Lewis base).")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_22695> "A molecular entity having an available pair of electrons capable of forming a covalent bond with a hydron (Brønsted base) or with the vacant orbital of some other molecular entity (Lewis base).")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_22695> "base")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_22695> <http://purl.obolibrary.org/obo/CHEBI_51086>)
 
@@ -10408,7 +10491,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_22728> <http://purl.obolibrary.
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_228364> (NMR chemical shift reference compound)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_228364> "Any compound that produces a peak used as reference frequency in the delta chemical shift scale.")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_228364> "Any compound that produces a peak used as reference frequency in the δ chemical shift scale.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_228364> "NMR chemical shift reference compound")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_228364> <http://purl.obolibrary.org/obo/CHEBI_33232>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_228364> <http://purl.obolibrary.org/obo/CHEBI_51086>)
@@ -10425,7 +10508,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_22868> <http://purl.obolibrary.
 AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_23004> "The univalent carboacyl group formed by loss of -OH from the carboxy group of carbamic acid.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_23004> "carbamoyl group")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_23004> <http://purl.obolibrary.org/obo/CHEBI_27207>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_23004> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_substituent_group_from> <http://purl.obolibrary.org/obo/CHEBI_28616>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_23004> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018037> <http://purl.obolibrary.org/obo/CHEBI_28616>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_23019> (carbonyl group)
 
@@ -10444,6 +10527,14 @@ AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.ob
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_23367> "molecular entity")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_23367> <http://purl.obolibrary.org/obo/CHEBI_24431>)
 
+# Class: <http://purl.obolibrary.org/obo/CHEBI_234420> ((S)-noradrenaline(1+))
+
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_234420> "An organic cation that is the conjugate acid of (<i>S</i>)-noradrenaline, obtained by protonation of the primary amino group; major species at pH 7.3.")
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_234420> "(S)-noradrenaline(1+)")
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_234420> <http://purl.obolibrary.org/obo/CHEBI_166902>)
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_234420> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018034> <http://purl.obolibrary.org/obo/CHEBI_33571>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_234420> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018039> <http://purl.obolibrary.org/obo/CHEBI_72587>))
+
 # Class: <http://purl.obolibrary.org/obo/CHEBI_23449> (cyclic peptide)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_23449> "cyclic peptide")
@@ -10470,14 +10561,14 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_23924> <http://purl.obolibrary.
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_24318> (glutamine family amino acid)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_24318> "An L-alpha-amino acid which is L-glutamic acid or any of the essential amino acids biosynthesised from it (glutamine, proline and arginine). A closed class.")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_24318> "An <small>L</small>-α-amino acid which is <small>L</small>-glutamic acid or any of the essential amino acids biosynthesised from it (glutamine, proline and arginine). A closed class.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_24318> "glutamine family amino acid")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_24318> <http://purl.obolibrary.org/obo/CHEBI_15705>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_24318> <http://purl.obolibrary.org/obo/CHEBI_83813>)
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_24319> (EC 6.3.1.2 (glutamate--ammonia ligase) inhibitor)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_24319> "An EC 6.3.* (C-N bond-forming ligase) inhibitor that interferes with the action of glutamate--ammonia ligase (EC 6.3.1.2).")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_24319> "An EC 6.3.* (<em>C</em>‒<em>N</em> bond-forming ligase) inhibitor that interferes with the action of glutamate—ammonia ligase (EC 6.3.1.2).")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_24319> "EC 6.3.1.2 (glutamate--ammonia ligase) inhibitor")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_24319> <http://purl.obolibrary.org/obo/CHEBI_76823>)
 
@@ -10525,9 +10616,17 @@ AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_24621> "hor
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_24621> <http://purl.obolibrary.org/obo/CHEBI_33280>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_24621> <http://purl.obolibrary.org/obo/CHEBI_48705>)
 
+# Class: <http://purl.obolibrary.org/obo/CHEBI_24636> (proton)
+
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_24636> "Nuclear particle of charge number +1, spin 1/2 and rest mass of 1.007276470(12) u.")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_24636> "Nuclear particle of charge number +1, spin ½ and rest mass of 1.007276470(12) u.")
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_24636> "proton")
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_24636> <http://purl.obolibrary.org/obo/CHEBI_15378>)
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_24636> <http://purl.obolibrary.org/obo/CHEBI_33253>)
+
 # Class: <http://purl.obolibrary.org/obo/CHEBI_24651> (hydroxides)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_24651> "Hydroxides are chemical compounds containing a hydroxy group or salts containing hydroxide (OH(-)).")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_24651> "Hydroxides are chemical compounds containing a hydroxy group or salts containing hydroxide (OH<small><sup>−</small></sup>).")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_24651> "hydroxides")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_24651> <http://purl.obolibrary.org/obo/CHEBI_25806>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_24651> <http://purl.obolibrary.org/obo/CHEBI_33608>)
@@ -10536,11 +10635,11 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_24651> ObjectSomeValuesFrom(<ht
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_24663> (hydroxy-5beta-cholanic acid)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_24663> "Any member of the class of 5beta-cholanic acids carrying at least one hydroxy group at unspecified position.")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_24663> "Any member of the class of 5β-cholanic acids carrying at least one hydroxy group at unspecified position.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_24663> "hydroxy-5beta-cholanic acid")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_24663> <http://purl.obolibrary.org/obo/CHEBI_33822>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_24663> <http://purl.obolibrary.org/obo/CHEBI_36248>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_24663> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#has_functional_parent> <http://purl.obolibrary.org/obo/CHEBI_36238>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_24663> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018038> <http://purl.obolibrary.org/obo/CHEBI_36238>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_24828> (indoles)
 
@@ -10631,7 +10730,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_25367> <http://purl.obolibrary.
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_25375> (monoamine molecular messenger)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_25375> "A group of neurotransmitters and neuromodulators that contain one amino group that is connected to an aromatic ring by ethylene group  (-CH2-CH2-). Monoamines are derived from the aromatic amino acids phenylalanine, tyrosine, histidine and tryptophan.")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_25375> "A group of neurotransmitters and neuromodulators that contain one amino group that is connected to an aromatic ring by ethylene group  (‒CH<small><sub>2</sub></small>‒CH<small><sub>2</sub></small>‒). Monoamines are derived from the aromatic amino acids phenylalanine, tyrosine, histidine and tryptophan.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_25375> "monoamine molecular messenger")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_25375> <http://purl.obolibrary.org/obo/CHEBI_63534>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_25375> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_33280>))
@@ -10641,7 +10740,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_25375> ObjectSomeValuesFrom(<ht
 AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_25384> "An oxoacid containing a single carboxy group.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_25384> "monocarboxylic acid")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_25384> <http://purl.obolibrary.org/obo/CHEBI_33575>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_25384> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of> <http://purl.obolibrary.org/obo/CHEBI_35757>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_25384> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018034> <http://purl.obolibrary.org/obo/CHEBI_35757>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_25414> (monoatomic monocation)
 
@@ -10692,7 +10791,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_25699> <http://purl.obolibrary.
 AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_25704> "Compounds of the general formula SO3HOR where R is an organyl group")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_25704> "organic sulfate")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_25704> <http://purl.obolibrary.org/obo/CHEBI_26820>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_25704> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of> <http://purl.obolibrary.org/obo/CHEBI_58958>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_25704> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018034> <http://purl.obolibrary.org/obo/CHEBI_58958>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_25741> (oxide)
 
@@ -10727,7 +10826,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_25905> ObjectSomeValuesFrom(<ht
 AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_26167> "Any amino acid whose side chain is capable of forming one or more hydrogen bonds.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_26167> "polar amino acid")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_26167> <http://purl.obolibrary.org/obo/CHEBI_33709>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_26167> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_tautomer_of> <http://purl.obolibrary.org/obo/CHEBI_62031>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_26167> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018036> <http://purl.obolibrary.org/obo/CHEBI_62031>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_26607> (saturated fatty acid)
 
@@ -10737,10 +10836,10 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_26607> <http://purl.obolibrary.
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_26666> (short-chain fatty acid)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_26666> "An aliphatic monocarboxylic acid with a chain length of less than C6. If any non-hydrocarbon substituent is present, the compound is not normally regarded as a short-chain fatty acid.")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_26666> "An aliphatic monocarboxylic acid with a chain length of less than C<small><sub>6</sub></small>. If any non-hydrocarbon substituent is present, the compound is not normally regarded as a short-chain fatty acid.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_26666> "short-chain fatty acid")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_26666> <http://purl.obolibrary.org/obo/CHEBI_35366>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_26666> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of> <http://purl.obolibrary.org/obo/CHEBI_58951>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_26666> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018034> <http://purl.obolibrary.org/obo/CHEBI_58951>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_26708> (sodium atom)
 
@@ -10805,7 +10904,7 @@ AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.ob
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_26836> "sulfuric acid")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_26836> <http://purl.obolibrary.org/obo/CHEBI_33402>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_26836> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_35223>))
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_26836> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of> <http://purl.obolibrary.org/obo/CHEBI_45696>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_26836> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018034> <http://purl.obolibrary.org/obo/CHEBI_45696>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_26932> (tetrapyrrole)
 
@@ -10854,7 +10953,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_27594> ObjectSomeValuesFrom(<ht
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_28087> (glycogen)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_28087> "A polydisperse, highly branched glucan composed of chains of D-glucopyranose residues in alpha(1->4) glycosidic linkage, joined together by alpha(1->6) glycosidic linkages. A small number of alpha(1->3) glycosidic linkages and some cumulative alpha(1->6) links also may occur. The branches in glycogen typically contain 8 to 12 glucose residues.")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_28087> "A polydisperse, highly branched glucan composed of chains of <small>D</small>-glucopyranose residues in α(1→4) glycosidic linkage, joined together by α(1→6) glycosidic linkages. A small number of α(1→3) glycosidic linkages and some cumulative α(1→6) links also may occur. The branches in glycogen typically contain 8 to 12 glucose residues.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_28087> "glycogen")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_28087> <http://purl.obolibrary.org/obo/BFO_0000004>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_28087> <http://purl.obolibrary.org/obo/CHEBI_24384>)
@@ -10869,7 +10968,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_28616> <http://purl.obolibrary.
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_28616> <http://purl.obolibrary.org/obo/CHEBI_35605>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_28616> <http://purl.obolibrary.org/obo/CHEBI_64708>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_28616> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_76971>))
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_28616> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of> <http://purl.obolibrary.org/obo/CHEBI_13941>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_28616> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018034> <http://purl.obolibrary.org/obo/CHEBI_13941>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_28790> (serotonin)
 
@@ -10883,8 +10982,8 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_28790> <http://purl.obolibrary.
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_28790> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_25512>))
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_28790> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_75771>))
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_28790> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_77746>))
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_28790> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#has_functional_parent> <http://purl.obolibrary.org/obo/CHEBI_16765>))
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_28790> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of> <http://purl.obolibrary.org/obo/CHEBI_350546>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_28790> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018033> <http://purl.obolibrary.org/obo/CHEBI_350546>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_28790> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018038> <http://purl.obolibrary.org/obo/CHEBI_16765>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_28868> (fatty acid anion)
 
@@ -10892,7 +10991,7 @@ AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.ob
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_28868> "fatty acid anion")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_28868> <http://purl.obolibrary.org/obo/CHEBI_18059>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_28868> <http://purl.obolibrary.org/obo/CHEBI_35757>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_28868> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of> <http://purl.obolibrary.org/obo/CHEBI_35366>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_28868> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018033> <http://purl.obolibrary.org/obo/CHEBI_35366>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_28938> (ammonium)
 
@@ -10906,7 +11005,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_28938> ObjectSomeValuesFrom(<ht
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_28938> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_75772>))
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_28938> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_76971>))
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_28938> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_77746>))
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_28938> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of> <http://purl.obolibrary.org/obo/CHEBI_16134>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_28938> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018034> <http://purl.obolibrary.org/obo/CHEBI_16134>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_28965> (dicarboxylic acid dianion)
 
@@ -10921,7 +11020,7 @@ AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_28976> "car
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_28976> <http://purl.obolibrary.org/obo/CHEBI_35605>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_28976> <http://purl.obolibrary.org/obo/CHEBI_36961>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_28976> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_75771>))
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_28976> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of> <http://purl.obolibrary.org/obo/CHEBI_17544>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_28976> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018034> <http://purl.obolibrary.org/obo/CHEBI_17544>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_29067> (carboxylic acid anion)
 
@@ -10929,7 +11028,7 @@ AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.ob
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_29067> "carboxylic acid anion")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_29067> <http://purl.obolibrary.org/obo/CHEBI_25696>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_29067> <http://purl.obolibrary.org/obo/CHEBI_35406>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_29067> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of> <http://purl.obolibrary.org/obo/CHEBI_33575>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_29067> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018033> <http://purl.obolibrary.org/obo/CHEBI_33575>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_29101> (sodium(1+))
 
@@ -10948,8 +11047,8 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_29101> ObjectSomeValuesFrom(<ht
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_29337> "azanide")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_29337> <http://purl.obolibrary.org/obo/CHEBI_35106>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_29337> <http://purl.obolibrary.org/obo/CHEBI_79389>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_29337> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of> <http://purl.obolibrary.org/obo/CHEBI_29340>))
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_29337> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of> <http://purl.obolibrary.org/obo/CHEBI_16134>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_29337> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018033> <http://purl.obolibrary.org/obo/CHEBI_16134>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_29337> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018034> <http://purl.obolibrary.org/obo/CHEBI_29340>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_29340> (hydridonitrate(2-))
 
@@ -10957,59 +11056,59 @@ AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.ob
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_29340> "hydridonitrate(2-)")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_29340> <http://purl.obolibrary.org/obo/CHEBI_35106>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_29340> <http://purl.obolibrary.org/obo/CHEBI_79388>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_29340> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of> <http://purl.obolibrary.org/obo/CHEBI_29337>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_29340> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018033> <http://purl.obolibrary.org/obo/CHEBI_29337>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_29793> (hydridodioxygen(1+))
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_29793> "hydridodioxygen(1+)")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_29793> <http://purl.obolibrary.org/obo/CHEBI_33693>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_29793> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of> <http://purl.obolibrary.org/obo/CHEBI_15379>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_29793> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018034> <http://purl.obolibrary.org/obo/CHEBI_15379>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_29985> (L-glutamate(1-))
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_29985> "An alpha-amino-acid anion that is the conjugate base of L-glutamic acid, having anionic carboxy groups and a cationic amino group")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_29985> "An α-amino-acid anion that is the conjugate base of <small>L</small>-glutamic acid, having anionic carboxy groups and a cationic amino group")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_29985> "L-glutamate(1-)")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_29985> <http://purl.obolibrary.org/obo/CHEBI_14321>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_29985> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_24319>))
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_29985> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_75772>))
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_29985> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_77746>))
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_29985> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of> <http://purl.obolibrary.org/obo/CHEBI_29988>))
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_29985> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of> <http://purl.obolibrary.org/obo/CHEBI_16015>))
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_29985> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_enantiomer_of> <http://purl.obolibrary.org/obo/CHEBI_29986>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_29985> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018033> <http://purl.obolibrary.org/obo/CHEBI_16015>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_29985> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018034> <http://purl.obolibrary.org/obo/CHEBI_29988>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_29985> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018039> <http://purl.obolibrary.org/obo/CHEBI_29986>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_29986> (D-glutamate(1-))
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_29986> "An alpha-amino-acid anion that is the conjugate base of D-glutamic acid, having anionic carboxy groups and a cationic amino group")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_29986> "An α-amino-acid anion that is the conjugate base of <small>D</small>-glutamic acid, having anionic carboxy groups and a cationic amino group")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_29986> "D-glutamate(1-)")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_29986> <http://purl.obolibrary.org/obo/CHEBI_14321>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_29986> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of> <http://purl.obolibrary.org/obo/CHEBI_29989>))
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_29986> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of> <http://purl.obolibrary.org/obo/CHEBI_15966>))
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_29986> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_enantiomer_of> <http://purl.obolibrary.org/obo/CHEBI_29985>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_29986> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018033> <http://purl.obolibrary.org/obo/CHEBI_15966>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_29986> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018034> <http://purl.obolibrary.org/obo/CHEBI_29989>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_29986> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018039> <http://purl.obolibrary.org/obo/CHEBI_29985>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_29987> (glutamate(2-))
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_29987> "A dicarboxylic acid dianion that is the conjugate base of glutamate(1-).")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_29987> "A dicarboxylic acid dianion that is the conjugate base of glutamate(1−).")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_29987> "glutamate(2-)")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_29987> <http://purl.obolibrary.org/obo/BFO_0000004>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_29987> <http://purl.obolibrary.org/obo/CHEBI_28965>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_29987> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_78675>))
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_29987> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of> <http://purl.obolibrary.org/obo/CHEBI_14321>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_29987> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018033> <http://purl.obolibrary.org/obo/CHEBI_14321>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_29988> (L-glutamate(2-))
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_29988> "An L-alpha-amino acid anion that is the dianion obtained by the deprotonation of the both the carboxy groups of L-glutamic acid.")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_29988> "An <small>L</small>-α-amino acid anion that is the dianion obtained by the deprotonation of the both the carboxy groups of <small>L</small>-glutamic acid.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_29988> "L-glutamate(2-)")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_29988> <http://purl.obolibrary.org/obo/CHEBI_29987>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_29988> <http://purl.obolibrary.org/obo/CHEBI_59814>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_29988> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of> <http://purl.obolibrary.org/obo/CHEBI_29985>))
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_29988> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_enantiomer_of> <http://purl.obolibrary.org/obo/CHEBI_29989>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_29988> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018033> <http://purl.obolibrary.org/obo/CHEBI_29985>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_29988> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018039> <http://purl.obolibrary.org/obo/CHEBI_29989>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_29989> (D-glutamate(2-))
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_29989> "D-glutamate(2-)")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_29989> <http://purl.obolibrary.org/obo/CHEBI_29987>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_29989> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of> <http://purl.obolibrary.org/obo/CHEBI_29986>))
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_29989> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_enantiomer_of> <http://purl.obolibrary.org/obo/CHEBI_29988>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_29989> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018033> <http://purl.obolibrary.org/obo/CHEBI_29986>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_29989> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018039> <http://purl.obolibrary.org/obo/CHEBI_29988>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_30089> (acetate)
 
@@ -11019,23 +11118,23 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_30089> <http://purl.obolibrary.
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_30089> <http://purl.obolibrary.org/obo/CHEBI_35757>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_30089> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_75772>))
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_30089> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_77746>))
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_30089> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of> <http://purl.obolibrary.org/obo/CHEBI_15366>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_30089> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018033> <http://purl.obolibrary.org/obo/CHEBI_15366>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_30212> (photon)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_30212> "Particle of zero charge, zero rest mass, spin quantum number 1, energy hnu and momentum hnu/c (h is the Planck constant, nu the frequency of radiation and c the speed of light), carrier of electromagnetic force.")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_30212> "Particle of zero charge, zero rest mass, spin quantum number 1, energy <em>h</em><em>ν</em> and momentum <em>h</em><em>ν</em>/<em>c</em> (<em>h</em> is the Planck constant, <em>ν</em> the frequency of radiation and <em>c</em> the speed of light), carrier of electromagnetic force.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_30212> "photon")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_30212> <http://purl.obolibrary.org/obo/CHEBI_36341>)
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_30566> (gamma-aminobutyrate)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_30566> "An gamma-amino acid anion resulting from the deprotonation of the carboxy group of gamma-aminobutyric acid.")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_30566> "An γ-amino acid anion resulting from the deprotonation of the carboxy group of γ-aminobutyric acid.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_30566> "gamma-aminobutyrate")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_30566> <http://purl.obolibrary.org/obo/BFO_0000004>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_30566> <http://purl.obolibrary.org/obo/CHEBI_71666>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_30566> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_77746>))
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_30566> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#has_functional_parent> <http://purl.obolibrary.org/obo/CHEBI_17968>))
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_30566> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of> <http://purl.obolibrary.org/obo/CHEBI_16865>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_30566> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018033> <http://purl.obolibrary.org/obo/CHEBI_16865>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_30566> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018038> <http://purl.obolibrary.org/obo/CHEBI_17968>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_30772> (butyric acid)
 
@@ -11045,11 +11144,11 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_30772> <http://purl.obolibrary.
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_30772> <http://purl.obolibrary.org/obo/CHEBI_39418>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_30772> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_131604>))
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_30772> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_84087>))
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_30772> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of> <http://purl.obolibrary.org/obo/CHEBI_17968>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_30772> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018034> <http://purl.obolibrary.org/obo/CHEBI_17968>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_3098> (bile acid)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_3098> "Any member of a group of hydroxy-5beta-cholanic acids occuring in bile, where they are present as the sodium salts of their amides with glycine or taurine. In mammals bile acids almost invariably have 5beta-configuration.")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_3098> "Any member of a group of hydroxy-5β-cholanic acids occuring in bile, where they are present as the sodium salts of their amides with glycine or taurine. In mammals bile acids almost invariably have 5β-configuration.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_3098> "bile acid")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_3098> <http://purl.obolibrary.org/obo/CHEBI_138366>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_3098> <http://purl.obolibrary.org/obo/CHEBI_24663>)
@@ -11062,7 +11161,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_32952> <http://purl.obolibrary.
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_32988> (amide)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_32988> "An amide is a derivative of an oxoacid RkE(=O)l(OH)m (l =/= 0) in which an acidic hydroxy group has been replaced by an amino or substituted amino group.")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_32988> "An amide is a derivative of an oxoacid R<small><sub><em>k</em></sub></small>E(=O)<small><sub><em>l</em></sub></small>(OH)<small><sub><em>m</em></sub></small> (<em>l</em> ≠ 0) in which an acidic hydroxy group has been replaced by an amino or substituted amino group.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_32988> "amide")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_32988> <http://purl.obolibrary.org/obo/CHEBI_51143>)
 
@@ -11088,7 +11187,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33238> <http://purl.obolibrary.
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_33241> "oxoacid derivative")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33241> <http://purl.obolibrary.org/obo/CHEBI_37577>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33241> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#has_functional_parent> <http://purl.obolibrary.org/obo/CHEBI_24833>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33241> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018038> <http://purl.obolibrary.org/obo/CHEBI_24833>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_33242> (inorganic hydride)
 
@@ -11114,8 +11213,8 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33246> <http://purl.obolibrary.
 AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_33247> "Any substituent group or skeleton containing carbon.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_33247> "organic group")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33247> <http://purl.obolibrary.org/obo/CHEBI_24433>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33247> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of> <http://purl.obolibrary.org/obo/CHEBI_64775>))
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33247> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of> <http://purl.obolibrary.org/obo/CHEBI_64769>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33247> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018033> <http://purl.obolibrary.org/obo/CHEBI_64769>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33247> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018034> <http://purl.obolibrary.org/obo/CHEBI_64775>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_33249> (organyl group)
 
@@ -11131,11 +11230,18 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33250> <http://purl.obolibrary.
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33250> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> <http://purl.obolibrary.org/obo/CHEBI_10545>))
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33250> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> <http://purl.obolibrary.org/obo/CHEBI_33252>))
 
+# Class: <http://purl.obolibrary.org/obo/CHEBI_33251> (monoatomic hydrogen)
+
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_33251> "monoatomic hydrogen")
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33251> <http://purl.obolibrary.org/obo/CHEBI_33238>)
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33251> <http://purl.obolibrary.org/obo/CHEBI_33260>)
+
 # Class: <http://purl.obolibrary.org/obo/CHEBI_33252> (atomic nucleus)
 
 AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_33252> "A nucleus is the positively charged central portion of an atom, excluding the orbital electrons.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_33252> "atomic nucleus")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33252> <http://purl.obolibrary.org/obo/CHEBI_36347>)
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33252> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> <http://purl.obolibrary.org/obo/CHEBI_24636>))
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33252> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> <http://purl.obolibrary.org/obo/CHEBI_33253>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_33253> (nucleon)
@@ -11147,7 +11253,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33253> <http://purl.obolibrary.
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_33256> (primary amide)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_33256> "A derivative of an oxoacid RkE(=O)l(OH)m (l =/= 0) in which an acidic hydroxy group has been replaced by an amino or substituted amino group.")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_33256> "A derivative of an oxoacid R<small><sub><em>k</em></sub></small>E(=O)<small><sub><em>l</em></sub></small>(OH)<small><sub><em>m</em></sub></small> (<em>l</em> ≠ 0) in which an acidic hydroxy group has been replaced by an amino or substituted amino group.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_33256> "primary amide")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33256> <http://purl.obolibrary.org/obo/CHEBI_32988>)
 
@@ -11157,6 +11263,13 @@ AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.ob
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_33259> "elemental molecular entity")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33259> <http://purl.obolibrary.org/obo/CHEBI_23367>)
 
+# Class: <http://purl.obolibrary.org/obo/CHEBI_33260> (elemental hydrogen)
+
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_33260> "elemental hydrogen")
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33260> <http://purl.obolibrary.org/obo/CHEBI_24835>)
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33260> <http://purl.obolibrary.org/obo/CHEBI_33259>)
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33260> <http://purl.obolibrary.org/obo/CHEBI_33608>)
+
 # Class: <http://purl.obolibrary.org/obo/CHEBI_33262> (elemental oxygen)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_33262> "elemental oxygen")
@@ -11239,7 +11352,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33306> <http://purl.obolibrary.
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_33308> (carboxylic ester)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_33308> "An ester of a carboxylic acid, R(1)C(=O)OR(2), where R(1) = H or organyl and R(2) = organyl.")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_33308> "An ester of a carboxylic acid, R<small><sup>1</small></sup>C(=O)OR<small><sup>2</small></sup>, where R<small><sup>1</small></sup> = H or organyl and R<small><sup>2</small></sup> = organyl.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_33308> "carboxylic ester")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33308> <http://purl.obolibrary.org/obo/CHEBI_35701>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33308> <http://purl.obolibrary.org/obo/CHEBI_36586>)
@@ -11292,10 +11405,10 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33521> <http://purl.obolibrary.
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_33558> (alpha-amino-acid anion)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_33558> "An amino-acid anion obtained by deprotonation of any alpha-amino acid.")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_33558> "An amino-acid anion obtained by deprotonation of any α-amino acid.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_33558> "alpha-amino-acid anion")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33558> <http://purl.obolibrary.org/obo/CHEBI_37022>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33558> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of> <http://purl.obolibrary.org/obo/CHEBI_33704>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33558> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018033> <http://purl.obolibrary.org/obo/CHEBI_33704>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_33559> (s-block element atom)
 
@@ -11310,7 +11423,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33560> <http://purl.obolibrary.
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_33566> (catechols)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_33566> "Any compound containing an o-diphenol component.")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_33566> "Any compound containing an <em>o</em>-diphenol component.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_33566> "catechols")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33566> <http://purl.obolibrary.org/obo/CHEBI_33570>)
 
@@ -11327,7 +11440,7 @@ AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.ob
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_33569> "noradrenaline")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33569> <http://purl.obolibrary.org/obo/CHEBI_33567>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33569> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_76967>))
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33569> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of> <http://purl.obolibrary.org/obo/CHEBI_166902>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33569> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018033> <http://purl.obolibrary.org/obo/CHEBI_166902>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_33570> (benzenediols)
 
@@ -11336,20 +11449,21 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33570> <http://purl.obolibrary.
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_33571> ((S)-noradrenaline)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_33571> "The S-enantiomer of noradrenaline.")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_33571> "The <i>S</i>-enantiomer of noradrenaline.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_33571> "(S)-noradrenaline")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33571> <http://purl.obolibrary.org/obo/CHEBI_33569>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33571> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_enantiomer_of> <http://purl.obolibrary.org/obo/CHEBI_18357>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33571> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018033> <http://purl.obolibrary.org/obo/CHEBI_234420>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33571> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018039> <http://purl.obolibrary.org/obo/CHEBI_18357>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_33575> (carboxylic acid)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_33575> "A carbon oxoacid acid carrying at least one -C(=O)OH group and having the structure RC(=O)OH, where R is any any monovalent functional group. Carboxylic acids are the most common type of organic acid.")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_33575> "A carbon oxoacid acid carrying at least one ‒C(=O)OH group and having the structure RC(=O)OH, where R is any any monovalent functional group. Carboxylic acids are the most common type of organic acid.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_33575> "carboxylic acid")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33575> <http://purl.obolibrary.org/obo/CHEBI_35605>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33575> <http://purl.obolibrary.org/obo/CHEBI_36586>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33575> <http://purl.obolibrary.org/obo/CHEBI_64709>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33575> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> <http://purl.obolibrary.org/obo/CHEBI_46883>))
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33575> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of> <http://purl.obolibrary.org/obo/CHEBI_29067>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33575> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018034> <http://purl.obolibrary.org/obo/CHEBI_29067>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_33579> (main group molecular entity)
 
@@ -11389,7 +11503,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33636> <http://purl.obolibrary.
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_33655> (aromatic compound)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_33655> "A cyclically conjugated molecular entity with a stability (due to delocalization) significantly greater than that of a hypothetical localized structure (e.g. Kekule structure) is said to possess aromatic character.")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_33655> "A cyclically conjugated molecular entity with a stability (due to delocalization) significantly greater than that of a hypothetical localized structure (e.g. Kekulé structure) is said to possess aromatic character.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_33655> "aromatic compound")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33655> <http://purl.obolibrary.org/obo/CHEBI_33595>)
 
@@ -11453,7 +11567,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33695> <http://purl.obolibrary.
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_33696> (nucleic acid)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_33696> "A macromolecule made up of nucleotide units and hydrolysable into certain pyrimidine or purine bases (usually adenine, cytosine, guanine, thymine, uracil), D-ribose or 2-deoxy-D-ribose and phosphoric acid.")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_33696> "A macromolecule made up of nucleotide units and hydrolysable into certain pyrimidine or purine bases (usually adenine, cytosine, guanine, thymine, uracil), <small>D</small>-ribose or 2-deoxy-<small>D</small>-ribose and phosphoric acid.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_33696> "nucleic acid")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33696> <http://purl.obolibrary.org/obo/CHEBI_15986>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33696> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> <http://purl.obolibrary.org/obo/CHEBI_33791>))
@@ -11484,32 +11598,32 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33702> <http://purl.obolibrary.
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_33703> "amino-acid cation")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33703> <http://purl.obolibrary.org/obo/CHEBI_25697>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33703> <http://purl.obolibrary.org/obo/CHEBI_33702>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33703> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of> <http://purl.obolibrary.org/obo/CHEBI_33709>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33703> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018034> <http://purl.obolibrary.org/obo/CHEBI_33709>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_33704> (alpha-amino acid)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_33704> "An amino acid in which the amino group is located on the carbon atom at the position alpha to the carboxy group.")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_33704> "An amino acid in which the amino group is located on the carbon atom at the position α to the carboxy group.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_33704> "alpha-amino acid")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33704> <http://purl.obolibrary.org/obo/CHEBI_33709>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33704> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of> <http://purl.obolibrary.org/obo/CHEBI_33558>))
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33704> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of> <http://purl.obolibrary.org/obo/CHEBI_33719>))
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33704> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_tautomer_of> <http://purl.obolibrary.org/obo/CHEBI_78608>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33704> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018033> <http://purl.obolibrary.org/obo/CHEBI_33719>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33704> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018034> <http://purl.obolibrary.org/obo/CHEBI_33558>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33704> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018036> <http://purl.obolibrary.org/obo/CHEBI_78608>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_33707> (gamma-amino acid)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_33707> "A non-proteinogenic amino-acid in which the amino group is located on the carbon atom at the position gamma to the carboxy group.")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_33707> "A non-proteinogenic amino-acid in which the amino group is located on the carbon atom at the position γ to the carboxy group.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_33707> "gamma-amino acid")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33707> <http://purl.obolibrary.org/obo/CHEBI_83820>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33707> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of> <http://purl.obolibrary.org/obo/CHEBI_71666>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33707> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018034> <http://purl.obolibrary.org/obo/CHEBI_71666>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_33708> (amino-acid residue)
 
 AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_33708> "When two or more amino acids combine to form a peptide, the elements of water are removed, and what remains of each amino acid is called an amino-acid residue.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_33708> "amino-acid residue")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33708> <http://purl.obolibrary.org/obo/CHEBI_33247>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33708> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of> <http://purl.obolibrary.org/obo/CHEBI_64898>))
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33708> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of> <http://purl.obolibrary.org/obo/CHEBI_58942>))
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33708> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_substituent_group_from> <http://purl.obolibrary.org/obo/CHEBI_33709>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33708> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018033> <http://purl.obolibrary.org/obo/CHEBI_58942>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33708> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018034> <http://purl.obolibrary.org/obo/CHEBI_64898>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33708> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018037> <http://purl.obolibrary.org/obo/CHEBI_33709>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_33709> (amino acid)
 
@@ -11517,34 +11631,34 @@ AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.ob
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_33709> "amino acid")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33709> <http://purl.obolibrary.org/obo/CHEBI_33575>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33709> <http://purl.obolibrary.org/obo/CHEBI_50047>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33709> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of> <http://purl.obolibrary.org/obo/CHEBI_37022>))
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33709> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of> <http://purl.obolibrary.org/obo/CHEBI_33703>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33709> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018033> <http://purl.obolibrary.org/obo/CHEBI_33703>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33709> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018034> <http://purl.obolibrary.org/obo/CHEBI_37022>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_33710> (alpha-amino-acid residue)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_33710> "An amino-acid residue derived from an alpha-amino acid.")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_33710> "An amino-acid residue derived from an α-amino acid.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_33710> "alpha-amino-acid residue")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33710> <http://purl.obolibrary.org/obo/CHEBI_33708>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33710> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_substituent_group_from> <http://purl.obolibrary.org/obo/CHEBI_33704>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33710> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018037> <http://purl.obolibrary.org/obo/CHEBI_33704>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_33719> (alpha-amino-acid cation)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_33719> "alpha-amino-acid cation")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33719> <http://purl.obolibrary.org/obo/CHEBI_33703>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33719> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of> <http://purl.obolibrary.org/obo/CHEBI_33704>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33719> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018034> <http://purl.obolibrary.org/obo/CHEBI_33704>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_33720> (carbohydrate acid)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_33720> "carbohydrate acid")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33720> <http://purl.obolibrary.org/obo/CHEBI_16646>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33720> <http://purl.obolibrary.org/obo/CHEBI_33575>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33720> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of> <http://purl.obolibrary.org/obo/CHEBI_33721>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33720> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018034> <http://purl.obolibrary.org/obo/CHEBI_33721>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_33721> (carbohydrate acid anion)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_33721> "carbohydrate acid anion")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33721> <http://purl.obolibrary.org/obo/CHEBI_29067>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33721> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of> <http://purl.obolibrary.org/obo/CHEBI_33720>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33721> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018033> <http://purl.obolibrary.org/obo/CHEBI_33720>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_33791> (canonical nucleoside residue)
 
@@ -11572,7 +11686,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33832> <http://purl.obolibrary.
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_33833> (heteroarene)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_33833> "A heterocyclic compound formally derived from an arene by replacement of one or more methine (-C=) and/or vinylene (-CH=CH-) groups by trivalent or divalent heteroatoms, respectively, in such a way as to maintain the continuous pi-electron system characteristic of aromatic systems and a number of out-of-plane pi-electrons corresponding to the Hueckel rule (4n+2).")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_33833> "A heterocyclic compound formally derived from an arene by replacement of one or more methine (‒C=) and/or vinylene (‒CH=CH‒) groups by trivalent or divalent heteroatoms, respectively, in such a way as to maintain the continuous π-electron system characteristic of aromatic systems and a number of out-of-plane π-electrons corresponding to the Hückel rule (4<em>n</em>+2).")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_33833> "heteroarene")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33833> <http://purl.obolibrary.org/obo/CHEBI_24532>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33833> <http://purl.obolibrary.org/obo/CHEBI_33659>)
@@ -11622,7 +11736,7 @@ AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_350546> "se
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_350546> <http://purl.obolibrary.org/obo/BFO_0000004>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_350546> <http://purl.obolibrary.org/obo/CHEBI_35274>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_350546> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_77746>))
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_350546> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of> <http://purl.obolibrary.org/obo/CHEBI_28790>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_350546> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018034> <http://purl.obolibrary.org/obo/CHEBI_28790>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_35106> (nitrogen hydride)
 
@@ -11632,7 +11746,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_35106> <http://purl.obolibrary.
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_35107> (azane)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_35107> "Saturated acyclic nitrogen hydrides having the general formula NnHn+2.")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_35107> "Saturated acyclic nitrogen hydrides having the general formula N<small><sub><em>n</em></sub></small>H<small><sub><em>n</em>+2</sub></small>.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_35107> "azane")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_35107> <http://purl.obolibrary.org/obo/CHEBI_35106>)
 
@@ -11656,19 +11770,19 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_35238> <http://purl.obolibrary.
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_35267> (quaternary ammonium ion)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_35267> "A derivative of ammonium, NH4(+), in which all four of the hydrogens bonded to nitrogen have been replaced with univalent (usually organyl) groups.")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_35267> "A derivative of ammonium, NH<small><sub>4</sub></small><small><sup>+</small></sup>, in which all four of the hydrogens bonded to nitrogen have been replaced with univalent (usually organyl) groups.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_35267> "quaternary ammonium ion")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_35267> <http://purl.obolibrary.org/obo/CHEBI_25697>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_35267> <http://purl.obolibrary.org/obo/CHEBI_35274>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_35267> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#has_parent_hydride> <http://purl.obolibrary.org/obo/CHEBI_28938>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_35267> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018040> <http://purl.obolibrary.org/obo/CHEBI_28938>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_35274> (ammonium ion derivative)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_35274> "A derivative of ammonium, NH4(+), in which one (or more) of the hydrogens bonded to the nitrogen have been replaced with univalent organyl groups. The substituting carbon of the organyl group must not itself be directly attached to a heteroatom (thereby excluding protonated amides, hemiaminals, etc).")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_35274> "A derivative of ammonium, NH<small><sub>4</sub></small><small><sup>+</small></sup>, in which one (or more) of the hydrogens bonded to the nitrogen have been replaced with univalent organyl groups. The substituting carbon of the organyl group must not itself be directly attached to a heteroatom (thereby excluding protonated amides, hemiaminals, etc).")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_35274> "ammonium ion derivative")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_35274> <http://purl.obolibrary.org/obo/CHEBI_33702>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_35274> <http://purl.obolibrary.org/obo/CHEBI_51143>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_35274> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#has_parent_hydride> <http://purl.obolibrary.org/obo/CHEBI_28938>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_35274> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018040> <http://purl.obolibrary.org/obo/CHEBI_28938>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_35287> (acylcholine)
 
@@ -11678,7 +11792,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_35287> <http://purl.obolibrary.
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_35341> (steroid)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_35341> "Any of naturally occurring compounds and synthetic analogues, based on the cyclopenta[a]phenanthrene carbon skeleton, partially or completely hydrogenated; there are usually methyl groups at C-10 and C-13, and often an alkyl group at C-17. By extension, one or more bond scissions, ring expansions and/or ring contractions of the skeleton may have occurred. Natural steroids are derived biogenetically from squalene which is a triterpene.")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_35341> "Any of naturally occurring compounds and synthetic analogues, based on the cyclopenta[<em>a</em>]phenanthrene carbon skeleton, partially or completely hydrogenated; there are usually methyl groups at C-10 and C-13, and often an alkyl group at C-17. By extension, one or more bond scissions, ring expansions and/or ring contractions of the skeleton may have occurred. Natural steroids are derived biogenetically from squalene which is a triterpene.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_35341> "steroid")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_35341> <http://purl.obolibrary.org/obo/CHEBI_18059>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_35341> <http://purl.obolibrary.org/obo/CHEBI_51958>)
@@ -11702,11 +11816,11 @@ AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.ob
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_35366> "fatty acid")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_35366> <http://purl.obolibrary.org/obo/CHEBI_18059>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_35366> <http://purl.obolibrary.org/obo/CHEBI_25384>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_35366> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of> <http://purl.obolibrary.org/obo/CHEBI_28868>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_35366> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018034> <http://purl.obolibrary.org/obo/CHEBI_28868>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_35381> (monosaccharide)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_35381> "Parent monosaccharides are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H-[CHOH]n-C(=O)[CHOH]m-H with three or more carbon atoms. The generic term 'monosaccharide' (as opposed to oligosaccharide or polysaccharide) denotes a single unit, without glycosidic connection to other such units. It includes aldoses, dialdoses, aldoketoses, ketoses and diketoses, as well as deoxy sugars, provided that the parent compound has a (potential) carbonyl group.")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_35381> "Parent monosaccharides are polyhydroxy aldehydes H[CH(OH)]<small><sub><em>n</em></sub></small>C(=O)H or polyhydroxy ketones H‒[CHOH]<small><sub><em>n</em></sub></small>‒C(=O)[CHOH]<small><sub><em>m</em></sub></small>‒H with three or more carbon atoms. The generic term 'monosaccharide' (as opposed to oligosaccharide or polysaccharide) denotes a single unit, without glycosidic connection to other such units. It includes aldoses, dialdoses, aldoketoses, ketoses and diketoses, as well as deoxy sugars, provided that the parent compound has a (potential) carbonyl group.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_35381> "monosaccharide")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_35381> <http://purl.obolibrary.org/obo/CHEBI_16646>)
 
@@ -11760,14 +11874,14 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_35554> <http://purl.obolibrary.
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_35569> (alpha-adrenergic agonist)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_35569> "An agent that selectively binds to and activates alpha-adrenergic receptors.")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_35569> "An agent that selectively binds to and activates α-adrenergic receptors.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_35569> "alpha-adrenergic agonist")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_35569> <http://purl.obolibrary.org/obo/CHEBI_37886>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_35569> <http://purl.obolibrary.org/obo/CHEBI_48539>)
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_35604> (carbon oxoanion)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_35604> "A negative ion consisting solely of carbon and oxygen  atoms, and therefore having the general formula CxOy(n-) for some integers x, y and n.")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_35604> "A negative ion consisting solely of carbon and oxygen  atoms, and therefore having the general formula C<small><sub><em>x</em></sub></small>O<small><sub><em>y</em></sub></small><small><sup><em>n</em>−</small></sup> for some integers <em>x</em>, <em>y</em> and <em>n</em>.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_35604> "carbon oxoanion")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_35604> <http://purl.obolibrary.org/obo/CHEBI_25696>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_35604> <http://purl.obolibrary.org/obo/CHEBI_35406>)
@@ -11791,17 +11905,17 @@ AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.ob
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_35692> "dicarboxylic acid")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_35692> <http://purl.obolibrary.org/obo/CHEBI_131927>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_35692> <http://purl.obolibrary.org/obo/CHEBI_33575>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_35692> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of> <http://purl.obolibrary.org/obo/CHEBI_35693>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_35692> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018034> <http://purl.obolibrary.org/obo/CHEBI_35693>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_35693> (dicarboxylic acid anion)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_35693> "dicarboxylic acid anion")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_35693> <http://purl.obolibrary.org/obo/CHEBI_29067>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_35693> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of> <http://purl.obolibrary.org/obo/CHEBI_35692>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_35693> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018033> <http://purl.obolibrary.org/obo/CHEBI_35692>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_35701> (ester)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_35701> "A compound formally derived from an oxoacid RkE(=O)l(OH)m (l > 0) and an alcohol, phenol, heteroarenol, or enol by linking with formal loss of water from an acidic hydroxy group of the former and a hydroxy group of the latter.")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_35701> "A compound formally derived from an oxoacid R<small><sub><em>k</em></sub></small>E(=O)<small><sub><em>l</em></sub></small>(OH)<small><sub><em>m</em></sub></small> (<em>l</em> > 0) and an alcohol, phenol, heteroarenol, or enol by linking with formal loss of water from an acidic hydroxy group of the former and a hydroxy group of the latter.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_35701> "ester")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_35701> <http://purl.obolibrary.org/obo/CHEBI_36963>)
 
@@ -11823,7 +11937,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_35724> <http://purl.obolibrary.
 AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_35757> "A carboxylic acid anion formed when the carboxy group of a monocarboxylic acid is deprotonated.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_35757> "monocarboxylic acid anion")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_35757> <http://purl.obolibrary.org/obo/CHEBI_29067>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_35757> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of> <http://purl.obolibrary.org/obo/CHEBI_25384>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_35757> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018033> <http://purl.obolibrary.org/obo/CHEBI_25384>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_35881> (pnictogen hydride)
 
@@ -11842,7 +11956,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_35942> <http://purl.obolibrary.
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_36078> "cholanoid")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_36078> <http://purl.obolibrary.org/obo/CHEBI_35341>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_36078> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#has_parent_hydride> <http://purl.obolibrary.org/obo/CHEBI_35519>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_36078> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018040> <http://purl.obolibrary.org/obo/CHEBI_35519>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_36080> (protein)
 
@@ -11871,11 +11985,11 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_36238> <http://purl.obolibrary.
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_36248> (5beta-cholanic acids)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_36248> "Members of the class of cholanic acids based on a 5beta-cholane skeleton.")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_36248> "Members of the class of cholanic acids based on a 5β-cholane skeleton.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_36248> "5beta-cholanic acids")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_36248> <http://purl.obolibrary.org/obo/CHEBI_136889>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_36248> <http://purl.obolibrary.org/obo/CHEBI_36278>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_36248> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#has_parent_hydride> <http://purl.obolibrary.org/obo/CHEBI_20664>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_36248> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018040> <http://purl.obolibrary.org/obo/CHEBI_20664>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_36277> (bile acid salt)
 
@@ -11892,14 +12006,14 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_36278> <http://purl.obolibrary.
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_36338> (lepton)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_36338> "Lepton is a fermion that does not experience the strong force (strong interaction). The term is derived from the Greek lambdaepsilonpitauomicronsigma (small, thin).")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_36338> "Lepton is a fermion that does not experience the strong force (strong interaction). The term is derived from the Greek λεπτοσ (small, thin).")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_36338> "lepton")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_36338> <http://purl.obolibrary.org/obo/CHEBI_33233>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_36338> <http://purl.obolibrary.org/obo/CHEBI_36340>)
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_36339> (baryon)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_36339> "Baryon is a fermion that does experience the strong force (strong interaction). The term is derived from the Greek betaalpharhoupsilonsigma (heavy).")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_36339> "Baryon is a fermion that does experience the strong force (strong interaction). The term is derived from the Greek βαρυσ (heavy).")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_36339> "baryon")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_36339> <http://purl.obolibrary.org/obo/CHEBI_36340>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_36339> <http://purl.obolibrary.org/obo/CHEBI_36344>)
@@ -11920,6 +12034,8 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_36341> <http://purl.obolibrary.
 
 AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_36342> "A particle smaller than an atom.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_36342> "subatomic particle")
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_36342> <http://purl.obolibrary.org/obo/BFO_0000040>)
+DisjointClasses(<http://purl.obolibrary.org/obo/CHEBI_36342> <http://purl.obolibrary.org/obo/COB_0000011>)
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_36343> (composite particle)
 
@@ -12022,7 +12138,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_36963> <http://purl.obolibrary.
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_37022> "amino-acid anion")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_37022> <http://purl.obolibrary.org/obo/CHEBI_29067>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_37022> <http://purl.obolibrary.org/obo/CHEBI_35352>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_37022> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of> <http://purl.obolibrary.org/obo/CHEBI_33709>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_37022> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018033> <http://purl.obolibrary.org/obo/CHEBI_33709>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_37163> (glucan)
 
@@ -12059,7 +12175,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_37395> <http://purl.obolibrary.
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_37527> (acid)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_37527> "An acid is a molecular entity capable of donating a hydron (Bronsted acid) or capable of forming a covalent bond with an electron pair (Lewis acid).")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_37527> "An acid is a molecular entity capable of donating a hydron (Brønsted acid) or capable of forming a covalent bond with an electron pair (Lewis acid).")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_37527> "acid")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_37527> <http://purl.obolibrary.org/obo/CHEBI_51086>)
 
@@ -12071,7 +12187,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_37577> <http://purl.obolibrary.
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_37622> (carboxamide)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_37622> "An amide of a carboxylic acid, having the structure RC(=O)NR2. The term is used as a suffix in systematic name formation to denote the -C(=O)NH2 group including its carbon atom.")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_37622> "An amide of a carboxylic acid, having the structure RC(=O)NR<small><sub>2</sub></small>. The term is used as a suffix in systematic name formation to denote the ‒C(=O)NH<small><sub>2</sub></small> group including its carbon atom.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_37622> "carboxamide")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_37622> <http://purl.obolibrary.org/obo/CHEBI_33256>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_37622> <http://purl.obolibrary.org/obo/CHEBI_35352>)
@@ -12087,14 +12203,14 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_37661> <http://purl.obolibrary.
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_37826> "sulfuric acid derivative")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_37826> <http://purl.obolibrary.org/obo/CHEBI_33424>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_37826> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#has_functional_parent> <http://purl.obolibrary.org/obo/CHEBI_26836>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_37826> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018038> <http://purl.obolibrary.org/obo/CHEBI_26836>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_37838> (carboacyl group)
 
 AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_37838> "A carboacyl group is a group formed by loss of at least one OH from the carboxy group of a carboxylic acid.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_37838> "carboacyl group")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_37838> <http://purl.obolibrary.org/obo/CHEBI_22221>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_37838> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_substituent_group_from> <http://purl.obolibrary.org/obo/CHEBI_33575>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_37838> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018037> <http://purl.obolibrary.org/obo/CHEBI_33575>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_37886> (adrenergic agonist)
 
@@ -12176,14 +12292,14 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_38958> ObjectSomeValuesFrom(<ht
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_39141> (Bronsted acid)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_39141> "A molecular entity capable of donating a hydron to an acceptor (Bronsted base).")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_39141> "A molecular entity capable of donating a hydron to an acceptor (Brønsted base).")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_39141> "Bronsted acid")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_39141> <http://purl.obolibrary.org/obo/CHEBI_17891>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_39141> <http://purl.obolibrary.org/obo/CHEBI_37527>)
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_39142> (Bronsted base)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_39142> "A molecular entity capable of accepting a hydron from a donor (Bronsted acid).")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_39142> "A molecular entity capable of accepting a hydron from a donor (Brønsted acid).")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_39142> "Bronsted base")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_39142> <http://purl.obolibrary.org/obo/CHEBI_15339>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_39142> <http://purl.obolibrary.org/obo/CHEBI_22695>)
@@ -12201,17 +12317,17 @@ AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.ob
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_39418> "straight-chain saturated fatty acid")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_39418> <http://purl.obolibrary.org/obo/CHEBI_26607>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_39418> <http://purl.obolibrary.org/obo/CHEBI_59202>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_39418> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of> <http://purl.obolibrary.org/obo/CHEBI_58954>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_39418> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018034> <http://purl.obolibrary.org/obo/CHEBI_58954>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_41609> (carbonate)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_41609> "carbonate")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_41609> <http://purl.obolibrary.org/obo/CHEBI_35604>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_41609> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of> <http://purl.obolibrary.org/obo/CHEBI_17544>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_41609> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018033> <http://purl.obolibrary.org/obo/CHEBI_17544>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_4167> (D-glucopyranose)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_4167> "A glucopyranose having D-configuration.")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_4167> "A glucopyranose having <small>D</small>-configuration.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_4167> "D-glucopyranose")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_4167> <http://purl.obolibrary.org/obo/CHEBI_17634>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_4167> <http://purl.obolibrary.org/obo/CHEBI_37661>)
@@ -12222,7 +12338,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_4167> ObjectSomeValuesFrom(<htt
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_4194> (D-hexose)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_4194> "A hexose that has D-configuration at position 5.")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_4194> "A hexose that has <small>D</small>-configuration at position 5.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_4194> "D-hexose")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_4194> <http://purl.obolibrary.org/obo/CHEBI_18133>)
 
@@ -12235,8 +12351,8 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_43176> <http://purl.obolibrary.
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_45696> "hydrogensulfate")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_45696> <http://purl.obolibrary.org/obo/CHEBI_33482>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_45696> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of> <http://purl.obolibrary.org/obo/CHEBI_16189>))
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_45696> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of> <http://purl.obolibrary.org/obo/CHEBI_26836>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_45696> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018033> <http://purl.obolibrary.org/obo/CHEBI_26836>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_45696> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018034> <http://purl.obolibrary.org/obo/CHEBI_16189>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_46629> (oxo group)
 
@@ -12260,7 +12376,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_46883> <http://purl.obolibrary.
 AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_47622> "Any carboxylic ester where the carboxylic acid component is acetic acid.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_47622> "acetate ester")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_47622> <http://purl.obolibrary.org/obo/CHEBI_33308>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_47622> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#has_functional_parent> <http://purl.obolibrary.org/obo/CHEBI_15366>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_47622> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018038> <http://purl.obolibrary.org/obo/CHEBI_15366>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_47891> (steroid acid)
 
@@ -12268,7 +12384,7 @@ AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.ob
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_47891> "steroid acid")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_47891> <http://purl.obolibrary.org/obo/CHEBI_35341>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_47891> <http://purl.obolibrary.org/obo/CHEBI_64709>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_47891> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of> <http://purl.obolibrary.org/obo/CHEBI_50160>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_47891> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018034> <http://purl.obolibrary.org/obo/CHEBI_50160>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_48154> (sulfur oxide)
 
@@ -12291,7 +12407,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_48356> <http://purl.obolibrary.
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_48539> (alpha-adrenergic drug)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_48539> "Any drug that acts on an alpha-adrenergic receptor.")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_48539> "Any drug that acts on an α-adrenergic receptor.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_48539> "alpha-adrenergic drug")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_48539> <http://purl.obolibrary.org/obo/CHEBI_37962>)
 
@@ -12317,14 +12433,14 @@ AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_50047> "org
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_50047> <http://purl.obolibrary.org/obo/BFO_0000004>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_50047> <http://purl.obolibrary.org/obo/CHEBI_35352>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_50047> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_39142>))
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_50047> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#has_parent_hydride> <http://purl.obolibrary.org/obo/CHEBI_16134>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_50047> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018040> <http://purl.obolibrary.org/obo/CHEBI_16134>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_50160> (steroid acid anion)
 
 AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_50160> "Any anion formed by loss of a proton from a steroid acid.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_50160> "steroid acid anion")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_50160> <http://purl.obolibrary.org/obo/CHEBI_29067>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_50160> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of> <http://purl.obolibrary.org/obo/CHEBI_47891>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_50160> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018033> <http://purl.obolibrary.org/obo/CHEBI_47891>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_50297> (canonical nucleotide residue)
 
@@ -12404,7 +12520,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_50910> <http://purl.obolibrary.
 AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_50994> "A compound formally derived from ammonia by replacing one hydrogen atom by an organyl group.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_50994> "primary amino compound")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_50994> <http://purl.obolibrary.org/obo/CHEBI_50047>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_50994> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of> <http://purl.obolibrary.org/obo/CHEBI_65296>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_50994> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018033> <http://purl.obolibrary.org/obo/CHEBI_65296>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_51086> (chemical role)
 
@@ -12466,6 +12582,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_52210> <http://purl.obolibrary.
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_52211> (physiological role)
 
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_52211> "A biological role relating to the normal mechanisms and their interactions within a living system.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_52211> "physiological role")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_52211> <http://purl.obolibrary.org/obo/CHEBI_24432>)
 
@@ -12520,7 +12637,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_57887> <http://purl.obolibrary.
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_57887> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_75771>))
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_57887> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_76924>))
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_57887> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_77746>))
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_57887> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of> <http://purl.obolibrary.org/obo/CHEBI_16765>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_57887> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018034> <http://purl.obolibrary.org/obo/CHEBI_16765>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_57977> (bilirubin(2-))
 
@@ -12530,25 +12647,25 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_57977> <http://purl.obolibrary.
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_57977> <http://purl.obolibrary.org/obo/CHEBI_28965>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_57977> <http://purl.obolibrary.org/obo/CHEBI_59252>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_57977> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_77746>))
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_57977> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of> <http://purl.obolibrary.org/obo/CHEBI_16990>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_57977> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018033> <http://purl.obolibrary.org/obo/CHEBI_16990>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_58942> (cationic amino-acid residue)
 
 AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_58942> "An amino-acid residue protonated on nitrogen.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_58942> "cationic amino-acid residue")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_58942> <http://purl.obolibrary.org/obo/CHEBI_64769>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_58942> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of> <http://purl.obolibrary.org/obo/CHEBI_33708>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_58942> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018034> <http://purl.obolibrary.org/obo/CHEBI_33708>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_58951> (short-chain fatty acid anion)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_58951> "Any fatty acid anion obtained by removal of a proton from the carboxy group of a short-chain fatty acid (chain length of less than C6).")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_58951> "Any fatty acid anion obtained by removal of a proton from the carboxy group of a short-chain fatty acid (chain length of less than C<small><sub>6</sub></small>).")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_58951> "short-chain fatty acid anion")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_58951> <http://purl.obolibrary.org/obo/CHEBI_28868>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_58951> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of> <http://purl.obolibrary.org/obo/CHEBI_26666>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_58951> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018033> <http://purl.obolibrary.org/obo/CHEBI_26666>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_58953> (saturated fatty acid anion)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_58953> "Any fatty acid anion in which there is no C-C unsaturation.")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_58953> "Any fatty acid anion in which there is no C‒C unsaturation.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_58953> "saturated fatty acid anion")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_58953> <http://purl.obolibrary.org/obo/CHEBI_28868>)
 
@@ -12557,30 +12674,30 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_58953> <http://purl.obolibrary.
 AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_58954> "Any saturated fatty acid anion lacking a carbon side-chain.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_58954> "straight-chain saturated fatty acid anion")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_58954> <http://purl.obolibrary.org/obo/CHEBI_58953>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_58954> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of> <http://purl.obolibrary.org/obo/CHEBI_39418>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_58954> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018033> <http://purl.obolibrary.org/obo/CHEBI_39418>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_58958> (organosulfate oxoanion)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_58958> "An organic anion of general formula RS(=O)2O(-) where R is an organyl group.")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_58958> "An organic anion of general formula RS(=O)2O(−) where R is an organyl group.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_58958> "organosulfate oxoanion")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_58958> <http://purl.obolibrary.org/obo/CHEBI_25696>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_58958> <http://purl.obolibrary.org/obo/CHEBI_33482>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_58958> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#has_functional_parent> <http://purl.obolibrary.org/obo/CHEBI_16189>))
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_58958> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of> <http://purl.obolibrary.org/obo/CHEBI_25704>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_58958> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018033> <http://purl.obolibrary.org/obo/CHEBI_25704>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_58958> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018038> <http://purl.obolibrary.org/obo/CHEBI_16189>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_59202> (straight-chain fatty acid)
 
 AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_59202> "Any fatty acid whose skeletal carbon atoms form an unbranched open chain.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_59202> "straight-chain fatty acid")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_59202> <http://purl.obolibrary.org/obo/CHEBI_35366>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_59202> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of> <http://purl.obolibrary.org/obo/CHEBI_59203>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_59202> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018034> <http://purl.obolibrary.org/obo/CHEBI_59203>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_59203> (straight-chain fatty acid anion)
 
 AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_59203> "A fatty acid anion formed by deprotonation of the carboxylic acid functional group of a straight-chain fatty acid.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_59203> "straight-chain fatty acid anion")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_59203> <http://purl.obolibrary.org/obo/CHEBI_28868>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_59203> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of> <http://purl.obolibrary.org/obo/CHEBI_59202>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_59203> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018033> <http://purl.obolibrary.org/obo/CHEBI_59202>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_59252> (linear tetrapyrrole anion)
 
@@ -12597,31 +12714,31 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_59740> <http://purl.obolibrary.
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_59814> (L-alpha-amino acid anion)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_59814> "Conjugate base of an L-alpha-amino acid arising from deprotonation of the C-1 carboxy group.")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_59814> "Conjugate base of an <small>L</small>-α-amino acid arising from deprotonation of the C-1 carboxy group.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_59814> "L-alpha-amino acid anion")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_59814> <http://purl.obolibrary.org/obo/CHEBI_33558>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_59814> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of> <http://purl.obolibrary.org/obo/CHEBI_15705>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_59814> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018033> <http://purl.obolibrary.org/obo/CHEBI_15705>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_59869> (L-alpha-amino acid zwitterion)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_59869> "Zwitterionic form of an L-alpha-amino acid having an anionic carboxy group and a protonated amino group.")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_59869> "Zwitterionic form of an <small>L</small>-α-amino acid having an anionic carboxy group and a protonated amino group.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_59869> "L-alpha-amino acid zwitterion")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_59869> <http://purl.obolibrary.org/obo/CHEBI_78608>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_59869> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_tautomer_of> <http://purl.obolibrary.org/obo/CHEBI_15705>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_59869> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018036> <http://purl.obolibrary.org/obo/CHEBI_15705>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_59871> (D-alpha-amino acid zwitterion)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_59871> "Zwitterionic form of a D-alpha-amino acid having an anionic carboxy group and a protonated amino group.")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_59871> "Zwitterionic form of a <small>D</small>-α-amino acid having an anionic carboxy group and a protonated amino group.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_59871> "D-alpha-amino acid zwitterion")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_59871> <http://purl.obolibrary.org/obo/CHEBI_35238>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_59871> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_tautomer_of> <http://purl.obolibrary.org/obo/CHEBI_16733>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_59871> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018036> <http://purl.obolibrary.org/obo/CHEBI_16733>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_59888> (gamma-aminobutyric acid zwitterion)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_59888> "Zwitterionic form of gamma-aminobutyric acid having an anionic carboxy group and a protonated amino group.")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_59888> "Zwitterionic form of γ-aminobutyric acid having an anionic carboxy group and a protonated amino group.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_59888> "gamma-aminobutyric acid zwitterion")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_59888> <http://purl.obolibrary.org/obo/CHEBI_35238>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_59888> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_tautomer_of> <http://purl.obolibrary.org/obo/CHEBI_16865>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_59888> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018036> <http://purl.obolibrary.org/obo/CHEBI_16865>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_59999> (chemical substance)
 
@@ -12660,14 +12777,14 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_60242> <http://purl.obolibrary.
 AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_60466> "Zwitterionic form of any peptide where, in general, the amino terminus is positively charged and the carboxy terminus is negatively charged.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_60466> "peptide zwitterion")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_60466> <http://purl.obolibrary.org/obo/CHEBI_27369>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_60466> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_tautomer_of> <http://purl.obolibrary.org/obo/CHEBI_16670>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_60466> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018036> <http://purl.obolibrary.org/obo/CHEBI_16670>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_60895> (D-alpha-amino acid anion)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_60895> "Any alpha-amino acid anion in which the parent amino acid has D-configuration.")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_60895> "Any α-amino acid anion in which the parent amino acid has <small>D</small>-configuration.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_60895> "D-alpha-amino acid anion")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_60895> <http://purl.obolibrary.org/obo/CHEBI_33558>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_60895> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of> <http://purl.obolibrary.org/obo/CHEBI_16733>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_60895> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018033> <http://purl.obolibrary.org/obo/CHEBI_16733>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_61115> (EC 3.5.1.98 (histone deacetylase) inhibitor)
 
@@ -12681,7 +12798,7 @@ AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.ob
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_61120> "nucleobase-containing molecular entity")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_61120> <http://purl.obolibrary.org/obo/CHEBI_33833>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_61120> <http://purl.obolibrary.org/obo/CHEBI_51143>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_61120> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#has_functional_parent> <http://purl.obolibrary.org/obo/CHEBI_18282>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_61120> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018038> <http://purl.obolibrary.org/obo/CHEBI_18282>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_61469> (polyanionic polymer)
 
@@ -12695,7 +12812,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_61469> ObjectSomeValuesFrom(<ht
 AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_62031> "Zwitterionic form of a polar amino acid having an anionic carboxy group and a protonated amino group.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_62031> "polar amino acid zwitterion")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_62031> <http://purl.obolibrary.org/obo/CHEBI_35238>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_62031> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_tautomer_of> <http://purl.obolibrary.org/obo/CHEBI_26167>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_62031> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018036> <http://purl.obolibrary.org/obo/CHEBI_26167>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_62488> (signalling molecule)
 
@@ -12714,15 +12831,15 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_63248> <http://purl.obolibrary.
 AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_63299> "Any organooxygen compound derived from a carbohydrate by replacement of one or more hydroxy group(s) by an amino group, a thiol group or similar heteroatomic groups. The term also includes derivatives of these compounds.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_63299> "carbohydrate derivative")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_63299> <http://purl.obolibrary.org/obo/CHEBI_78616>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_63299> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#has_functional_parent> <http://purl.obolibrary.org/obo/CHEBI_16646>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_63299> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018038> <http://purl.obolibrary.org/obo/CHEBI_16646>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_63436> (carbohydrate acid derivative)
 
 AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_63436> "A carbohydrate derivative that is formally obtained from a carbohydrate acid.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_63436> "carbohydrate acid derivative")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_63436> <http://purl.obolibrary.org/obo/CHEBI_63299>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_63436> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#has_functional_parent> <http://purl.obolibrary.org/obo/CHEBI_33720>))
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_63436> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of> <http://purl.obolibrary.org/obo/CHEBI_63551>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_63436> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018034> <http://purl.obolibrary.org/obo/CHEBI_63551>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_63436> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018038> <http://purl.obolibrary.org/obo/CHEBI_33720>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_63534> (monoamine)
 
@@ -12735,8 +12852,8 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_63534> <http://purl.obolibrary.
 AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_63551> "A carboxylic acid anion resulting from the deprotonation of the carboxy group of a carbohydrate acid derivative.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_63551> "carbohydrate acid derivative anion")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_63551> <http://purl.obolibrary.org/obo/CHEBI_29067>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_63551> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#has_functional_parent> <http://purl.obolibrary.org/obo/CHEBI_33721>))
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_63551> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of> <http://purl.obolibrary.org/obo/CHEBI_63436>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_63551> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018033> <http://purl.obolibrary.org/obo/CHEBI_63436>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_63551> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018038> <http://purl.obolibrary.org/obo/CHEBI_33721>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_64047> (food additive)
 
@@ -12766,7 +12883,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_64628> <http://purl.obolibrary.
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_64708> (one-carbon compound)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_64708> "An organic molecular entity containing a single carbon atom (C1).")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_64708> "An organic molecular entity containing a single carbon atom (C<small><sub>1</sub></small>).")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_64708> "one-carbon compound")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_64708> <http://purl.obolibrary.org/obo/CHEBI_50860>)
 
@@ -12793,21 +12910,21 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_64767> <http://purl.obolibrary.
 AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_64769> "A cationic group that contains carbon.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_64769> "organic cationic group")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_64769> <http://purl.obolibrary.org/obo/CHEBI_64766>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_64769> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of> <http://purl.obolibrary.org/obo/CHEBI_33247>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_64769> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018034> <http://purl.obolibrary.org/obo/CHEBI_33247>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_64775> (organic anionic group)
 
 AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_64775> "An anionic group that contains carbon.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_64775> "organic anionic group")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_64775> <http://purl.obolibrary.org/obo/CHEBI_64767>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_64775> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of> <http://purl.obolibrary.org/obo/CHEBI_33247>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_64775> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018033> <http://purl.obolibrary.org/obo/CHEBI_33247>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_64898> (anionic amino-acid residue)
 
 AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_64898> "An amino-acid residue carrying an overall negative charge.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_64898> "anionic amino-acid residue")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_64898> <http://purl.obolibrary.org/obo/CHEBI_64775>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_64898> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of> <http://purl.obolibrary.org/obo/CHEBI_33708>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_64898> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018033> <http://purl.obolibrary.org/obo/CHEBI_33708>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_64909> (poison)
 
@@ -12822,7 +12939,7 @@ AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_65212> "pol
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_65212> <http://purl.obolibrary.org/obo/CHEBI_167559>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_65212> <http://purl.obolibrary.org/obo/CHEBI_33694>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_65212> <http://purl.obolibrary.org/obo/CHEBI_63299>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_65212> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#has_functional_parent> <http://purl.obolibrary.org/obo/CHEBI_18154>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_65212> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018038> <http://purl.obolibrary.org/obo/CHEBI_18154>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_65255> (food preservative)
 
@@ -12843,7 +12960,7 @@ AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.ob
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_65296> "primary ammonium ion")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_65296> <http://purl.obolibrary.org/obo/CHEBI_25697>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_65296> <http://purl.obolibrary.org/obo/CHEBI_35274>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_65296> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of> <http://purl.obolibrary.org/obo/CHEBI_50994>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_65296> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018034> <http://purl.obolibrary.org/obo/CHEBI_50994>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_67079> (anti-inflammatory agent)
 
@@ -12853,19 +12970,20 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_67079> <http://purl.obolibrary.
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_71666> (gamma-amino acid anion)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_71666> "An amino-acid anion in which the amino group is situated gamma- to the carboxylate group.")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_71666> "An amino-acid anion in which the amino group is situated γ- to the carboxylate group.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_71666> "gamma-amino acid anion")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_71666> <http://purl.obolibrary.org/obo/CHEBI_37022>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_71666> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of> <http://purl.obolibrary.org/obo/CHEBI_33707>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_71666> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018033> <http://purl.obolibrary.org/obo/CHEBI_33707>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_72587> ((R)-noradrenaline(1+))
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_72587> "An organic cation that is the conjugate acid of (R)-noradrenaline, obtained by protonation of the priamry amino group; major species at pH 7.3.")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_72587> "An organic cation that is the conjugate acid of (<i>R</i>)-noradrenaline, obtained by protonation of the primary amino group; major species at pH 7.3.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_72587> "(R)-noradrenaline(1+)")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_72587> <http://purl.obolibrary.org/obo/BFO_0000004>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_72587> <http://purl.obolibrary.org/obo/CHEBI_166902>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_72587> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_77746>))
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_72587> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of> <http://purl.obolibrary.org/obo/CHEBI_18357>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_72587> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018034> <http://purl.obolibrary.org/obo/CHEBI_18357>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_72587> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018039> <http://purl.obolibrary.org/obo/CHEBI_234420>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_72695> (organic molecule)
 
@@ -12894,7 +13012,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_73541> <http://purl.obolibrary.
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_75600> (EC 6.3.* (C-N bond-forming ligase) inhibitor)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_75600> "A ligase inhibitor that interferes with the action of a C-N bond-forming ligase (EC 6.3.*.*).")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_75600> "A ligase inhibitor that interferes with the action of a <em>C</em>‒<em>N</em> bond-forming ligase (EC 6.3.*.*).")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_75600> "EC 6.3.* (C-N bond-forming ligase) inhibitor")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_75600> <http://purl.obolibrary.org/obo/CHEBI_75603>)
 
@@ -12924,13 +13042,13 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_75768> <http://purl.obolibrary.
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_75771> (mouse metabolite)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_75771> "Any mammalian metabolite produced during a metabolic reaction in a mouse (Mus musculus).")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_75771> "Any mammalian metabolite produced during a metabolic reaction in a mouse (<em>Mus musculus</em>).")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_75771> "mouse metabolite")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_75771> <http://purl.obolibrary.org/obo/CHEBI_75768>)
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_75772> (Saccharomyces cerevisiae metabolite)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_75772> "Any  fungal metabolite produced during a metabolic reaction in Baker's yeast (Saccharomyces cerevisiae).")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_75772> "Any  fungal metabolite produced during a metabolic reaction in Baker's yeast (<em>Saccharomyces cerevisiae </em>).")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_75772> "Saccharomyces cerevisiae metabolite")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_75772> <http://purl.obolibrary.org/obo/CHEBI_76946>)
 
@@ -12966,7 +13084,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_76807> <http://purl.obolibrary.
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_76823> (EC 6.3.1.* (acid-ammonia/amine ligase) inhibitor)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_76823> "An EC 6.3.* (C-N bond-forming ligase) inhibitor that interferes with the action of any acid-ammonia (or amine) ligase (EC 6.3.1.*).")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_76823> "An EC 6.3.* (<em>C</em>‒<em>N</em> bond-forming ligase) inhibitor that interferes with the action of any acid-ammonia (or amine) ligase (EC 6.3.1.*).")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_76823> "EC 6.3.1.* (acid-ammonia/amine ligase) inhibitor")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_76823> <http://purl.obolibrary.org/obo/CHEBI_75600>)
 
@@ -12997,13 +13115,13 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_76969> <http://purl.obolibrary.
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_76971> (Escherichia coli metabolite)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_76971> "Any bacterial metabolite produced during a metabolic reaction in Escherichia coli.")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_76971> "Any bacterial metabolite produced during a metabolic reaction in <em>Escherichia coli</em>.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_76971> "Escherichia coli metabolite")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_76971> <http://purl.obolibrary.org/obo/CHEBI_76969>)
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_77746> (human metabolite)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_77746> "Any mammalian metabolite  produced during a metabolic reaction in humans (Homo sapiens).")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_77746> "Any mammalian metabolite  produced during a metabolic reaction in humans (<em>Homo sapiens</em>).")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_77746> "human metabolite")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_77746> <http://purl.obolibrary.org/obo/CHEBI_75768>)
 
@@ -13025,7 +13143,7 @@ AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.ob
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_78115> "fatty acid anion 4:0")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_78115> <http://purl.obolibrary.org/obo/CHEBI_58951>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_78115> <http://purl.obolibrary.org/obo/CHEBI_58953>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_78115> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of> <http://purl.obolibrary.org/obo/CHEBI_140601>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_78115> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018033> <http://purl.obolibrary.org/obo/CHEBI_140601>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_78295> (food component)
 
@@ -13041,14 +13159,14 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_78433> <http://purl.obolibrary.
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_78608> (alpha-amino-acid zwitterion)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_78608> "An amino acid-zwitterion obtained by transfer of a proton from the carboxy to the amino group of any alpha-amino acid; major species at pH 7.3.")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_78608> "An amino acid-zwitterion obtained by transfer of a proton from the carboxy to the amino group of any α-amino acid; major species at pH 7.3.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_78608> "alpha-amino-acid zwitterion")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_78608> <http://purl.obolibrary.org/obo/CHEBI_35238>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_78608> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_tautomer_of> <http://purl.obolibrary.org/obo/CHEBI_33704>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_78608> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0018036> <http://purl.obolibrary.org/obo/CHEBI_33704>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_78616> (carbohydrates and carbohydrate derivatives)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_78616> "Any organooxygen compound that is a polyhydroxy-aldehyde or -ketone, or a compound derived from one. Carbohydrates contain only carbon, hydrogen and oxygen and usually have an empirical formula Cm(H2O)n; carbohydrate derivatives may contain other elements by substitution or condensation.")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_78616> "Any organooxygen compound that is a polyhydroxy-aldehyde or -ketone, or a compound derived from one. Carbohydrates contain only carbon, hydrogen and oxygen and usually have an empirical formula C<small><sub><em>m</em></sub></small>(H<small><sub>2</sub></small>O)<small><sub><em>n</em></sub></small>; carbohydrate derivatives may contain other elements by substitution or condensation.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_78616> "carbohydrates and carbohydrate derivatives")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_78616> <http://purl.obolibrary.org/obo/CHEBI_36963>)
 
@@ -13078,19 +13196,19 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_83039> <http://purl.obolibrary.
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_83056> (Daphnia magna metabolite)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_83056> "A Daphnia metabolite produced by the species Daphnia magna.")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_83056> "A <em>Daphnia</em> metabolite produced by the species <em>Daphnia magna</em>.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_83056> "Daphnia magna metabolite")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_83056> <http://purl.obolibrary.org/obo/CHEBI_83057>)
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_83057> (Daphnia metabolite)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_83057> "A crustacean metabolite produced by the genus of small planktonic arthropods, Daphnia")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_83057> "A crustacean metabolite produced by the genus of small planktonic arthropods, <em>Daphnia</em>")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_83057> "Daphnia metabolite")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_83057> <http://purl.obolibrary.org/obo/CHEBI_83039>)
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_83813> (proteinogenic amino acid)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_83813> "Any of the 23 alpha-amino acids that are precursors to proteins, and are incorporated into proteins during translation. The group includes the 20 amino acids encoded by the nuclear genes of eukaryotes together with selenocysteine, pyrrolysine, and N-formylmethionine. Apart from glycine, which is non-chiral, all have L configuration.")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_83813> "Any of the 23 α-amino acids that are precursors to proteins, and are incorporated into proteins during translation. The group includes the 20 amino acids encoded by the nuclear genes of eukaryotes together with selenocysteine, pyrrolysine, and <em>N</em>-formylmethionine. Apart from glycine, which is non-chiral, all have <small>L</small> configuration.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_83813> "proteinogenic amino acid")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_83813> <http://purl.obolibrary.org/obo/CHEBI_33709>)
 
@@ -13102,7 +13220,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_83820> <http://purl.obolibrary.
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_83925> (non-proteinogenic alpha-amino acid)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_83925> "Any  alpha-amino acid which is not a member of the group of 23 proteinogenic amino acids.")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_83925> "Any  α-amino acid which is not a member of the group of 23 proteinogenic amino acids.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_83925> "non-proteinogenic alpha-amino acid")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_83925> <http://purl.obolibrary.org/obo/CHEBI_33704>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_83925> <http://purl.obolibrary.org/obo/CHEBI_83820>)
@@ -13128,6 +13246,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/CL_0000000> ObjectSomeValuesFrom(<htt
 DisjointClasses(<http://purl.obolibrary.org/obo/CL_0000000> <http://purl.obolibrary.org/obo/GO_0031012>)
 DisjointClasses(<http://purl.obolibrary.org/obo/CL_0000000> <http://purl.obolibrary.org/obo/GO_0032991>)
 DisjointClasses(<http://purl.obolibrary.org/obo/CL_0000000> <http://purl.obolibrary.org/obo/GO_0043226>)
+DisjointClasses(<http://purl.obolibrary.org/obo/CL_0000000> <http://purl.obolibrary.org/obo/GO_0044423>)
 
 # Class: <http://purl.obolibrary.org/obo/CL_0000005> (neural crest derived fibroblast)
 
@@ -13723,6 +13842,7 @@ AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasExactSynony
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CL_0000138> "chondrocyte")
 SubClassOf(<http://purl.obolibrary.org/obo/CL_0000138> <http://purl.obolibrary.org/obo/CL_0000153>)
 SubClassOf(<http://purl.obolibrary.org/obo/CL_0000138> <http://purl.obolibrary.org/obo/CL_0000667>)
+SubClassOf(<http://purl.obolibrary.org/obo/CL_0000138> <http://purl.obolibrary.org/obo/CL_0007001>)
 SubClassOf(<http://purl.obolibrary.org/obo/CL_0000138> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0001025> <http://purl.obolibrary.org/obo/UBERON_0002418>))
 SubClassOf(<http://purl.obolibrary.org/obo/CL_0000138> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002202> <http://purl.obolibrary.org/obo/CL_0000058>))
 
@@ -17988,6 +18108,44 @@ EquivalentClasses(<http://purl.obolibrary.org/obo/CL_4072102> ObjectIntersection
 SubClassOf(<http://purl.obolibrary.org/obo/CL_4072102> <http://purl.obolibrary.org/obo/CL_4023057>)
 SubClassOf(<http://purl.obolibrary.org/obo/CL_4072102> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002100> <http://purl.obolibrary.org/obo/UBERON_0002979>))
 
+# Class: <http://purl.obolibrary.org/obo/COB_0000011> (atom)
+
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/COB_0000011> "A material entity consisting of exactly one atomic nucleus and the electron(s) orbiting it."@en)
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/COB_0000011> "atom"@en)
+SubClassOf(<http://purl.obolibrary.org/obo/COB_0000011> <http://purl.obolibrary.org/obo/BFO_0000040>)
+SubClassOf(<http://purl.obolibrary.org/obo/COB_0000011> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> <http://purl.obolibrary.org/obo/CHEBI_33252>))
+DisjointClasses(<http://purl.obolibrary.org/obo/COB_0000011> <http://purl.obolibrary.org/obo/COB_0000013>)
+
+# Class: <http://purl.obolibrary.org/obo/COB_0000013> (molecule)
+
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/COB_0000013> "A material entity that consists of two or more atoms that are all connected via covalent bonds such that any atom can be transitively connected with any other atom."@en)
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/COB_0000013> "molecule"@en)
+SubClassOf(<http://purl.obolibrary.org/obo/COB_0000013> <http://purl.obolibrary.org/obo/BFO_0000040>)
+SubClassOf(<http://purl.obolibrary.org/obo/COB_0000013> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> <http://purl.obolibrary.org/obo/COB_0000011>))
+
+# Class: <http://purl.obolibrary.org/obo/COB_0000021> (gross anatomical part)
+
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/COB_0000021> "A part of a multicellular organism that is a collection of cell components that are not all contained in one cell."@en)
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/COB_0000021> "gross anatomical part"@en)
+SubClassOf(<http://purl.obolibrary.org/obo/COB_0000021> <http://purl.obolibrary.org/obo/UBERON_0000465>)
+
+# Class: <http://purl.obolibrary.org/obo/COB_0000022> (organism)
+
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/COB_0000022> "A material entity that is a maximal functionally integrated unit that develops from a program encoded in a genome"@en)
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/COB_0000022> "organism"@en)
+SubClassOf(<http://purl.obolibrary.org/obo/COB_0000022> <http://purl.obolibrary.org/obo/UBERON_0000465>)
+
+# Class: <http://purl.obolibrary.org/obo/COB_0000080> (complex of molecules)
+
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/COB_0000080> "A complex of two or more molecules that are not covalently bound."@en)
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/COB_0000080> "complex of molecules"@en)
+SubClassOf(<http://purl.obolibrary.org/obo/COB_0000080> <http://purl.obolibrary.org/obo/BFO_0000040>)
+SubClassOf(<http://purl.obolibrary.org/obo/COB_0000080> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> <http://purl.obolibrary.org/obo/COB_0000013>))
+
+# Class: <http://purl.obolibrary.org/obo/COB_0000502> (characteristic)
+
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/COB_0000502> "characteristic"@en)
+
 # Class: <http://purl.obolibrary.org/obo/GO_0000011> (vacuole inheritance)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0000011> "vacuole inheritance")
@@ -21904,6 +22062,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0003433> ObjectSomeValuesFrom(<htt
 # Class: <http://purl.obolibrary.org/obo/GO_0003674> (molecular_function)
 
 AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasExactSynonym> <http://purl.obolibrary.org/obo/GO_0003674> "molecular function")
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0003674> "gene product or complex activity"@en)
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0003674> "molecular_function")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0003674> <http://purl.obolibrary.org/obo/BFO_0000015>)
 DisjointClasses(<http://purl.obolibrary.org/obo/GO_0003674> <http://purl.obolibrary.org/obo/GO_0005575>)
@@ -21975,6 +22134,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0005326> ObjectSomeValuesFrom(<htt
 AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasExactSynonym> <http://purl.obolibrary.org/obo/GO_0005575> "cell or subcellular entity")
 AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasExactSynonym> <http://purl.obolibrary.org/obo/GO_0005575> "cellular component")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0005575> "cellular_component")
+EquivalentClasses(<http://purl.obolibrary.org/obo/GO_0005575> ObjectUnionOf(<http://purl.obolibrary.org/obo/GO_0032991> <http://purl.obolibrary.org/obo/GO_0044423> <http://purl.obolibrary.org/obo/GO_0110165>))
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0005575> <http://purl.obolibrary.org/obo/BFO_0000040>)
 DisjointClasses(<http://purl.obolibrary.org/obo/GO_0005575> <http://purl.obolibrary.org/obo/GO_0008150>)
 
@@ -24252,8 +24412,10 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0008104> ObjectSomeValuesFrom(<htt
 
 AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasExactSynonym> <http://purl.obolibrary.org/obo/GO_0008150> "biological process")
 AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasExactSynonym> <http://purl.obolibrary.org/obo/GO_0008150> "physiological process")
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0008150> "biological process"@en)
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0008150> "biological_process")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0008150> <http://purl.obolibrary.org/obo/BFO_0000015>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0008150> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> <http://purl.obolibrary.org/obo/GO_0003674>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0008152> (metabolic process)
 
@@ -25245,6 +25407,13 @@ EquivalentClasses(<http://purl.obolibrary.org/obo/GO_0010070> ObjectIntersection
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0010070> <http://purl.obolibrary.org/obo/GO_0008356>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0010070> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0004009> <http://purl.obolibrary.org/obo/CL_0000365>))
 
+# Class: <http://purl.obolibrary.org/obo/GO_0010155> (regulation of proton transport)
+
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0010155> "regulation of proton transport")
+EquivalentClasses(<http://purl.obolibrary.org/obo/GO_0010155> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/GO_0065007> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002211> <http://purl.obolibrary.org/obo/GO_1902600>)))
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0010155> <http://purl.obolibrary.org/obo/GO_1904062>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0010155> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002211> <http://purl.obolibrary.org/obo/GO_1902600>))
+
 # Class: <http://purl.obolibrary.org/obo/GO_0010160> (formation of animal organ boundary)
 
 AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasExactSynonym> <http://purl.obolibrary.org/obo/GO_0010160> "organ boundary specification")
@@ -27064,38 +27233,6 @@ DisjointClasses(<http://purl.obolibrary.org/obo/GO_0014874> ObjectSomeValuesFrom
 DisjointClasses(<http://purl.obolibrary.org/obo/GO_0014874> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_4896>))
 DisjointClasses(<http://purl.obolibrary.org/obo/GO_0014874> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_4932>))
 
-# Class: <http://purl.obolibrary.org/obo/GO_0014878> (response to electrical stimulus involved in regulation of muscle adaptation)
-
-AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0014878> "response to electrical stimulus involved in regulation of muscle adaptation")
-EquivalentClasses(<http://purl.obolibrary.org/obo/GO_0014878> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/GO_0051602> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/GO_0043502>)))
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0014878> <http://purl.obolibrary.org/obo/GO_0014874>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0014878> <http://purl.obolibrary.org/obo/GO_0051602>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0014878> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/GO_0043502>))
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0014878> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> ObjectComplementOf(<http://purl.obolibrary.org/obo/NCBITaxon_2>)))
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0014878> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> ObjectComplementOf(<http://purl.obolibrary.org/obo/NCBITaxon_2157>)))
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0014878> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> ObjectComplementOf(<http://purl.obolibrary.org/obo/NCBITaxon_4896>)))
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0014878> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> ObjectComplementOf(<http://purl.obolibrary.org/obo/NCBITaxon_4932>)))
-DisjointClasses(<http://purl.obolibrary.org/obo/GO_0014878> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_2>))
-DisjointClasses(<http://purl.obolibrary.org/obo/GO_0014878> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_2157>))
-DisjointClasses(<http://purl.obolibrary.org/obo/GO_0014878> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_4896>))
-DisjointClasses(<http://purl.obolibrary.org/obo/GO_0014878> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_4932>))
-
-# Class: <http://purl.obolibrary.org/obo/GO_0014879> (detection of electrical stimulus involved in regulation of muscle adaptation)
-
-AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0014879> "detection of electrical stimulus involved in regulation of muscle adaptation")
-EquivalentClasses(<http://purl.obolibrary.org/obo/GO_0014879> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/GO_0050981> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/GO_0043502>)))
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0014879> <http://purl.obolibrary.org/obo/GO_0014878>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0014879> <http://purl.obolibrary.org/obo/GO_0050981>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0014879> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/GO_0043502>))
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0014879> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> ObjectComplementOf(<http://purl.obolibrary.org/obo/NCBITaxon_2>)))
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0014879> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> ObjectComplementOf(<http://purl.obolibrary.org/obo/NCBITaxon_2157>)))
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0014879> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> ObjectComplementOf(<http://purl.obolibrary.org/obo/NCBITaxon_4896>)))
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0014879> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> ObjectComplementOf(<http://purl.obolibrary.org/obo/NCBITaxon_4932>)))
-DisjointClasses(<http://purl.obolibrary.org/obo/GO_0014879> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_2>))
-DisjointClasses(<http://purl.obolibrary.org/obo/GO_0014879> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_2157>))
-DisjointClasses(<http://purl.obolibrary.org/obo/GO_0014879> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_4896>))
-DisjointClasses(<http://purl.obolibrary.org/obo/GO_0014879> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_4932>))
-
 # Class: <http://purl.obolibrary.org/obo/GO_0014887> (cardiac muscle adaptation)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0014887> "cardiac muscle adaptation")
@@ -27244,6 +27381,17 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0015075> <http://purl.obolibrary.o
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0015075> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/GO_0034220>))
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0015075> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0004009> <http://purl.obolibrary.org/obo/CHEBI_24867>))
 
+# Class: <http://purl.obolibrary.org/obo/GO_0015078> (proton transmembrane transporter activity)
+
+AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasExactSynonym> <http://purl.obolibrary.org/obo/GO_0015078> "hydrogen ion transmembrane transporter activity")
+AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasExactSynonym> <http://purl.obolibrary.org/obo/GO_0015078> "proton transporter activity")
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0015078> "proton transmembrane transporter activity")
+EquivalentClasses(<http://purl.obolibrary.org/obo/GO_0015078> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/GO_0005215> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002342> <http://purl.obolibrary.org/obo/GO_0016020>) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0004009> <http://purl.obolibrary.org/obo/CHEBI_15378>)))
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0015078> <http://purl.obolibrary.org/obo/GO_0008324>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0015078> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/GO_1902600>))
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0015078> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002342> <http://purl.obolibrary.org/obo/GO_0016020>))
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0015078> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0004009> <http://purl.obolibrary.org/obo/CHEBI_15378>))
+
 # Class: <http://purl.obolibrary.org/obo/GO_0015081> (sodium ion transmembrane transporter activity)
 
 AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasExactSynonym> <http://purl.obolibrary.org/obo/GO_0015081> "sodium transporter activity")
@@ -30554,6 +30702,7 @@ AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0031012> "extr
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0031012> <http://purl.obolibrary.org/obo/GO_0030312>)
 DisjointClasses(<http://purl.obolibrary.org/obo/GO_0031012> <http://purl.obolibrary.org/obo/GO_0032991>)
 DisjointClasses(<http://purl.obolibrary.org/obo/GO_0031012> <http://purl.obolibrary.org/obo/GO_0043226>)
+DisjointClasses(<http://purl.obolibrary.org/obo/GO_0031012> <http://purl.obolibrary.org/obo/GO_0044423>)
 
 # Class: <http://purl.obolibrary.org/obo/GO_0031016> (pancreas development)
 
@@ -32176,8 +32325,10 @@ AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasExactSynony
 AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasExactSynonym> <http://purl.obolibrary.org/obo/GO_0032991> "macromolecule complex")
 AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasExactSynonym> <http://purl.obolibrary.org/obo/GO_0032991> "protein containing complex")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0032991> "protein-containing complex")
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0032991> <http://purl.obolibrary.org/obo/COB_0000080>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0032991> <http://purl.obolibrary.org/obo/GO_0005575>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0032991> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> <http://purl.obolibrary.org/obo/PR_000000001>))
+DisjointClasses(<http://purl.obolibrary.org/obo/GO_0032991> <http://purl.obolibrary.org/obo/GO_0044423>)
 DisjointClasses(<http://purl.obolibrary.org/obo/GO_0032991> <http://purl.obolibrary.org/obo/GO_0110165>)
 
 # Class: <http://purl.obolibrary.org/obo/GO_0033002> (muscle cell proliferation)
@@ -35025,6 +35176,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0043209> ObjectSomeValuesFrom(<htt
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0043226> "organelle")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0043226> <http://purl.obolibrary.org/obo/GO_0110165>)
+DisjointClasses(<http://purl.obolibrary.org/obo/GO_0043226> <http://purl.obolibrary.org/obo/GO_0044423>)
 
 # Class: <http://purl.obolibrary.org/obo/GO_0043227> (membrane-bounded organelle)
 
@@ -35839,6 +35991,16 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0044419> <http://purl.obolibrary.o
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0044419> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> ObjectComplementOf(<http://purl.obolibrary.org/obo/NCBITaxon_4895>)))
 DisjointClasses(<http://purl.obolibrary.org/obo/GO_0044419> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_4895>))
 
+# Class: <http://purl.obolibrary.org/obo/GO_0044423> (virion component)
+
+AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasExactSynonym> <http://purl.obolibrary.org/obo/GO_0044423> "virion part")
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0044423> "virion component")
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0044423> <http://purl.obolibrary.org/obo/GO_0005575>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0044423> ObjectComplementOf(ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_131567>)))
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0044423> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> ObjectComplementOf(<http://purl.obolibrary.org/obo/NCBITaxon_131567>)))
+DisjointClasses(<http://purl.obolibrary.org/obo/GO_0044423> <http://purl.obolibrary.org/obo/GO_0110165>)
+DisjointClasses(<http://purl.obolibrary.org/obo/GO_0044423> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_131567>))
+
 # Class: <http://purl.obolibrary.org/obo/GO_0044458> (motile cilium assembly)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0044458> "motile cilium assembly")
@@ -40876,12 +41038,6 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0050942> <http://purl.obolibrary.o
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0050942> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_131567>))
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0050942> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002213> <http://purl.obolibrary.org/obo/GO_0050931>))
 
-# Class: <http://purl.obolibrary.org/obo/GO_0050952> (sensory perception of electrical stimulus)
-
-AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0050952> "sensory perception of electrical stimulus")
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0050952> <http://purl.obolibrary.org/obo/GO_0007600>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0050952> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_33208>))
-
 # Class: <http://purl.obolibrary.org/obo/GO_0050953> (sensory perception of light stimulus)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0050953> "sensory perception of light stimulus")
@@ -40896,14 +41052,6 @@ AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0050954> "sens
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0050954> <http://purl.obolibrary.org/obo/GO_0007600>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0050954> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_33208>))
 
-# Class: <http://purl.obolibrary.org/obo/GO_0050956> (electroception)
-
-AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasExactSynonym> <http://purl.obolibrary.org/obo/GO_0050956> "electroception sense")
-AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasExactSynonym> <http://purl.obolibrary.org/obo/GO_0050956> "electroceptive sense")
-AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0050956> "electroception")
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0050956> <http://purl.obolibrary.org/obo/GO_0050952>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0050956> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_33208>))
-
 # Class: <http://purl.obolibrary.org/obo/GO_0050962> (detection of light stimulus involved in sensory perception)
 
 AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasExactSynonym> <http://purl.obolibrary.org/obo/GO_0050962> "sensory detection of light stimulus")
@@ -40920,46 +41068,6 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0050962> ObjectSomeValuesFrom(<htt
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0050962> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/GO_0050953>))
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0050962> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_33208>))
 
-# Class: <http://purl.obolibrary.org/obo/GO_0050963> (detection of electrical stimulus involved in sensory perception)
-
-AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasExactSynonym> <http://purl.obolibrary.org/obo/GO_0050963> "sensory detection of electrical stimulus")
-AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasExactSynonym> <http://purl.obolibrary.org/obo/GO_0050963> "sensory detection of electrical stimulus during sensory perception")
-AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasExactSynonym> <http://purl.obolibrary.org/obo/GO_0050963> "sensory perception, sensory detection of electrical stimulus")
-AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasExactSynonym> <http://purl.obolibrary.org/obo/GO_0050963> "sensory perception, sensory transduction of electrical stimulus")
-AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasExactSynonym> <http://purl.obolibrary.org/obo/GO_0050963> "sensory transduction of electrical stimulus")
-AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasExactSynonym> <http://purl.obolibrary.org/obo/GO_0050963> "sensory transduction of electrical stimulus during sensory perception")
-AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0050963> "detection of electrical stimulus involved in sensory perception")
-EquivalentClasses(<http://purl.obolibrary.org/obo/GO_0050963> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/GO_0050981> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/GO_0007600>)))
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0050963> <http://purl.obolibrary.org/obo/GO_0050906>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0050963> <http://purl.obolibrary.org/obo/GO_0050981>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0050963> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/GO_0007600>))
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0050963> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/GO_0050952>))
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0050963> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_33208>))
-
-# Class: <http://purl.obolibrary.org/obo/GO_0050964> (detection of electrical stimulus involved in electroception)
-
-AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasExactSynonym> <http://purl.obolibrary.org/obo/GO_0050964> "electroception, detection of electrical stimulus")
-AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasExactSynonym> <http://purl.obolibrary.org/obo/GO_0050964> "electroception, sensory detection of electrical stimulus")
-AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasExactSynonym> <http://purl.obolibrary.org/obo/GO_0050964> "electroception, sensory transduction")
-AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasExactSynonym> <http://purl.obolibrary.org/obo/GO_0050964> "electroception, sensory transduction of electrical stimulus")
-AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0050964> "detection of electrical stimulus involved in electroception")
-EquivalentClasses(<http://purl.obolibrary.org/obo/GO_0050964> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/GO_0050981> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/GO_0050956>)))
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0050964> <http://purl.obolibrary.org/obo/GO_0050963>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0050964> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/GO_0050956>))
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0050964> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_33208>))
-
-# Class: <http://purl.obolibrary.org/obo/GO_0050967> (detection of electrical stimulus involved in sensory perception of pain)
-
-AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasExactSynonym> <http://purl.obolibrary.org/obo/GO_0050967> "perception of pain, detection of electrical stimulus")
-AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasExactSynonym> <http://purl.obolibrary.org/obo/GO_0050967> "perception of pain, sensory detection of electrical stimulus")
-AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasExactSynonym> <http://purl.obolibrary.org/obo/GO_0050967> "perception of pain, sensory transduction of electrical stimulus")
-AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0050967> "detection of electrical stimulus involved in sensory perception of pain")
-EquivalentClasses(<http://purl.obolibrary.org/obo/GO_0050967> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/GO_0050981> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/GO_0019233>)))
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0050967> <http://purl.obolibrary.org/obo/GO_0050963>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0050967> <http://purl.obolibrary.org/obo/GO_0062149>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0050967> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/GO_0019233>))
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0050967> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_33208>))
-
 # Class: <http://purl.obolibrary.org/obo/GO_0050968> (detection of chemical stimulus involved in sensory perception of pain)
 
 AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasExactSynonym> <http://purl.obolibrary.org/obo/GO_0050968> "perception of pain, detection of chemical stimulus")
@@ -40984,12 +41092,6 @@ AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0050975> "sens
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0050975> <http://purl.obolibrary.org/obo/GO_0050954>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0050975> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_33208>))
 
-# Class: <http://purl.obolibrary.org/obo/GO_0050981> (detection of electrical stimulus)
-
-AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0050981> "detection of electrical stimulus")
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0050981> <http://purl.obolibrary.org/obo/GO_0009582>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0050981> <http://purl.obolibrary.org/obo/GO_0051602>)
-
 # Class: <http://purl.obolibrary.org/obo/GO_0050994> (regulation of lipid catabolic process)
 
 AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasExactSynonym> <http://purl.obolibrary.org/obo/GO_0050994> "regulation of lipid breakdown")
@@ -41831,11 +41933,6 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0051590> <http://purl.obolibrary.o
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0051590> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_33208>))
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0051590> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002213> <http://purl.obolibrary.org/obo/GO_0006836>))
 
-# Class: <http://purl.obolibrary.org/obo/GO_0051602> (response to electrical stimulus)
-
-AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0051602> "response to electrical stimulus")
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0051602> <http://purl.obolibrary.org/obo/GO_0009628>)
-
 # Class: <http://purl.obolibrary.org/obo/GO_0051606> (detection of stimulus)
 
 AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasExactSynonym> <http://purl.obolibrary.org/obo/GO_0051606> "stimulus detection")
@@ -49935,11 +50032,15 @@ DisjointClasses(<http://purl.obolibrary.org/obo/GO_0110125> ObjectSomeValuesFrom
 
 # Class: <http://purl.obolibrary.org/obo/GO_0110165> (cellular anatomical structure)
 
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/GO_0110165> "A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex.")
 AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasExactSynonym> <http://purl.obolibrary.org/obo/GO_0110165> "cellular anatomical entity")
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0110165> "cellular anatomical entity")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0110165> "cellular anatomical structure")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0110165> <http://purl.obolibrary.org/obo/CARO_0000000>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0110165> <http://purl.obolibrary.org/obo/GO_0005575>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0110165> <http://purl.obolibrary.org/obo/UBERON_0000061>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0110165> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> <http://purl.obolibrary.org/obo/COB_0000013>))
+DisjointClasses(<http://purl.obolibrary.org/obo/GO_0110165> <http://purl.obolibrary.org/obo/UBERON_0000001>)
 
 # Class: <http://purl.obolibrary.org/obo/GO_0120006> (regulation of glutamatergic neuron differentiation)
 
@@ -49975,6 +50076,18 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0120025> <http://purl.obolibrary.o
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0120025> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> <http://purl.obolibrary.org/obo/GO_0098590>))
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0120025> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_131567>))
 
+# Class: <http://purl.obolibrary.org/obo/GO_0120029> (proton export across plasma membrane)
+
+AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasExactSynonym> <http://purl.obolibrary.org/obo/GO_0120029> "hydrogen ion export across plasma membrane")
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0120029> "proton export across plasma membrane")
+EquivalentClasses(<http://purl.obolibrary.org/obo/GO_0120029> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/GO_0006810> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002338> <http://purl.obolibrary.org/obo/GO_0005829>) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002339> <http://purl.obolibrary.org/obo/GO_0005576>) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002342> <http://purl.obolibrary.org/obo/GO_0005886>) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0004009> <http://purl.obolibrary.org/obo/CHEBI_15378>)))
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0120029> <http://purl.obolibrary.org/obo/GO_0140115>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0120029> <http://purl.obolibrary.org/obo/GO_1902600>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0120029> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002338> <http://purl.obolibrary.org/obo/GO_0005829>))
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0120029> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002339> <http://purl.obolibrary.org/obo/GO_0005576>))
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0120029> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002342> <http://purl.obolibrary.org/obo/GO_0005886>))
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0120029> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0004009> <http://purl.obolibrary.org/obo/CHEBI_15378>))
+
 # Class: <http://purl.obolibrary.org/obo/GO_0120031> (plasma membrane bounded cell projection assembly)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0120031> "plasma membrane bounded cell projection assembly")
@@ -52728,6 +52841,15 @@ EquivalentClasses(<http://purl.obolibrary.org/obo/GO_1902570> ObjectIntersection
 SubClassOf(<http://purl.obolibrary.org/obo/GO_1902570> <http://purl.obolibrary.org/obo/GO_0034504>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_1902570> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002339> <http://purl.obolibrary.org/obo/GO_0005730>))
 
+# Class: <http://purl.obolibrary.org/obo/GO_1902600> (proton transmembrane transport)
+
+AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasExactSynonym> <http://purl.obolibrary.org/obo/GO_1902600> "hydrogen ion transmembrane transport")
+AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasExactSynonym> <http://purl.obolibrary.org/obo/GO_1902600> "hydrogen transmembrane transport")
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_1902600> "proton transmembrane transport")
+EquivalentClasses(<http://purl.obolibrary.org/obo/GO_1902600> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/GO_0055085> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0004009> <http://purl.obolibrary.org/obo/CHEBI_15378>)))
+SubClassOf(<http://purl.obolibrary.org/obo/GO_1902600> <http://purl.obolibrary.org/obo/GO_0098655>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_1902600> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0004009> <http://purl.obolibrary.org/obo/CHEBI_15378>))
+
 # Class: <http://purl.obolibrary.org/obo/GO_1902679> (negative regulation of RNA biosynthetic process)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_1902679> "negative regulation of RNA biosynthetic process")
@@ -58726,11 +58848,13 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_2001252> ObjectSomeValuesFrom(<htt
 
 # Class: <http://purl.obolibrary.org/obo/IAO_0000027> (data item)
 
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/IAO_0000027> "An information content entity that is intended to be a truthful statement about something (modulo, e.g., measurement precision or other systematic errors) and is constructed/acquired by a method which reliably tends to produce (approximately) truthful statements."@en)
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/IAO_0000027> "data item"@en)
 SubClassOf(<http://purl.obolibrary.org/obo/IAO_0000027> <http://purl.obolibrary.org/obo/IAO_0000030>)
 
 # Class: <http://purl.obolibrary.org/obo/IAO_0000030> (information content entity)
 
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/IAO_0000030> "A generically dependent continuant that is about some thing."@en)
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/IAO_0000030> "information content entity"@en)
 
 # Class: <http://purl.obolibrary.org/obo/IAO_0000078> (curation status specification)
@@ -58953,7 +59077,9 @@ DisjointClasses(<http://purl.obolibrary.org/obo/NCBITaxon_1312402> <http://purl.
 
 # Class: <http://purl.obolibrary.org/obo/NCBITaxon_131567> (cellular organisms)
 
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/NCBITaxon_131567> "cellular organism")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/NCBITaxon_131567> "cellular organisms")
+SubClassOf(<http://purl.obolibrary.org/obo/NCBITaxon_131567> <http://purl.obolibrary.org/obo/COB_0000022>)
 SubClassOf(<http://purl.obolibrary.org/obo/NCBITaxon_131567> <http://purl.obolibrary.org/obo/NCBITaxon_1>)
 
 # Class: <http://purl.obolibrary.org/obo/NCBITaxon_1329799> (Archelosauria)
@@ -60219,9 +60345,9 @@ SubClassOf(<http://purl.obolibrary.org/obo/PATO_0070060> <http://purl.obolibrary
 
 # Class: <http://purl.obolibrary.org/obo/PR_000000001> (protein)
 
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/PR_000000001> "An amino acid chain that is produced de novo by ribosome-mediated translation of a genetically-encoded mRNA, and any derivatives thereof.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/PR_000000001> "protein")
 EquivalentClasses(<http://purl.obolibrary.org/obo/PR_000000001> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/PR_000018263> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002353> <http://purl.obolibrary.org/obo/GO_0006412>) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/pr#has_gene_template> <http://purl.obolibrary.org/obo/SO_0001217>)))
-SubClassOf(<http://purl.obolibrary.org/obo/PR_000000001> <http://purl.obolibrary.org/obo/BFO_0000002>)
 SubClassOf(<http://purl.obolibrary.org/obo/PR_000000001> <http://purl.obolibrary.org/obo/PR_000018263>)
 SubClassOf(<http://purl.obolibrary.org/obo/PR_000000001> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> <http://purl.obolibrary.org/obo/PR_000000001>))
 SubClassOf(<http://purl.obolibrary.org/obo/PR_000000001> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002353> <http://purl.obolibrary.org/obo/GO_0006412>))
@@ -60726,6 +60852,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/PR_000016043> <http://purl.obolibrary
 
 # Class: <http://purl.obolibrary.org/obo/PR_000018263> (amino acid chain)
 
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/PR_000018263> "An organic amino compound that consists of amino acid residues (unmodified amino-acid residues and/or modified amino-acid residues) linked by peptide bonds or derivatives of such bonds.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/PR_000018263> "amino acid chain")
 SubClassOf(<http://purl.obolibrary.org/obo/PR_000018263> <http://purl.obolibrary.org/obo/COB_0000013>)
 SubClassOf(<http://purl.obolibrary.org/obo/PR_000018263> ObjectMinCardinality(2 <http://purl.obolibrary.org/obo/RO_0020337> <http://purl.obolibrary.org/obo/CHEBI_33708>))
@@ -61487,11 +61614,11 @@ AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.ob
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/RO_0002577> "system")
 SubClassOf(<http://purl.obolibrary.org/obo/RO_0002577> <http://purl.obolibrary.org/obo/BFO_0000040>)
 
-# Class: <http://purl.obolibrary.org/obo/UBERON_0000000> (processual entity)
+# Class: <http://purl.obolibrary.org/obo/UBERON_0000001> (gross anatomical part)
 
-AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/UBERON_0000000> "processual entity")
-SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0000000> <http://purl.obolibrary.org/obo/BFO_0000003>)
-DisjointClasses(<http://purl.obolibrary.org/obo/UBERON_0000000> <http://purl.obolibrary.org/obo/UBERON_0001062>)
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/UBERON_0000001> "gross anatomical part")
+SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0000001> <http://purl.obolibrary.org/obo/UBERON_0000465>)
+DisjointClasses(<http://purl.obolibrary.org/obo/UBERON_0000001> <http://purl.obolibrary.org/obo/UBERON_0000468>)
 
 # Class: <http://purl.obolibrary.org/obo/UBERON_0000005> (chemosensory organ)
 
@@ -61976,14 +62103,14 @@ AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasExactSynony
 AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasExactSynonym> <http://purl.obolibrary.org/obo/UBERON_0000104> "life")
 AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasExactSynonym> <http://purl.obolibrary.org/obo/UBERON_0000104> "lifespan")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/UBERON_0000104> "life cycle")
-SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0000104> <http://purl.obolibrary.org/obo/UBERON_0000000>)
+SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0000104> <http://purl.obolibrary.org/obo/BFO_0000015>)
 SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0000104> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> <http://purl.obolibrary.org/obo/UBERON_0000105>))
 SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0000104> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002230> <http://purl.obolibrary.org/obo/UBERON_0000071>))
 
 # Class: <http://purl.obolibrary.org/obo/UBERON_0000105> (life cycle stage)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/UBERON_0000105> "life cycle stage")
-SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0000105> <http://purl.obolibrary.org/obo/UBERON_0000000>)
+SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0000105> <http://purl.obolibrary.org/obo/BFO_0000015>)
 SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0000105> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000104>))
 
 # Class: <http://purl.obolibrary.org/obo/UBERON_0000106> (zygote stage)
@@ -62209,8 +62336,6 @@ SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0000170> ObjectSomeValuesFrom(
 SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0000170> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0001025> <http://purl.obolibrary.org/obo/UBERON_0002224>))
 SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0000170> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002351> <http://purl.obolibrary.org/obo/UBERON_0002167>))
 SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0000170> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002351> <http://purl.obolibrary.org/obo/UBERON_0002168>))
-SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0000170> ObjectExactCardinality(1 <http://purl.obolibrary.org/obo/RO_0002351> <http://purl.obolibrary.org/obo/UBERON_0002167>))
-SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0000170> ObjectExactCardinality(1 <http://purl.obolibrary.org/obo/RO_0002351> <http://purl.obolibrary.org/obo/UBERON_0002168>))
 
 # Class: <http://purl.obolibrary.org/obo/UBERON_0000171> (respiration organ)
 
@@ -62576,9 +62701,10 @@ SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0000457> ObjectSomeValuesFrom(
 # Class: <http://purl.obolibrary.org/obo/UBERON_0000463> (organism substance)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/UBERON_0000463> "organism substance")
-SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0000463> <http://purl.obolibrary.org/obo/UBERON_0000465>)
+SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0000463> <http://purl.obolibrary.org/obo/UBERON_0000001>)
 SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0000463> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000468>))
 SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0000463> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000086> <http://purl.obolibrary.org/obo/PATO_0002198>))
+DisjointClasses(<http://purl.obolibrary.org/obo/UBERON_0000463> <http://purl.obolibrary.org/obo/UBERON_0000468>)
 
 # Class: <http://purl.obolibrary.org/obo/UBERON_0000464> (anatomical space)
 
@@ -62590,6 +62716,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0000464> ObjectSomeValuesFrom(
 # Class: <http://purl.obolibrary.org/obo/UBERON_0000465> (material anatomical entity)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/UBERON_0000465> "material anatomical entity")
+EquivalentClasses(<http://purl.obolibrary.org/obo/UBERON_0000465> ObjectUnionOf(<http://purl.obolibrary.org/obo/CL_0000000> <http://purl.obolibrary.org/obo/COB_0000021> <http://purl.obolibrary.org/obo/COB_0000022> <http://purl.obolibrary.org/obo/GO_0110165>))
 SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0000465> <http://purl.obolibrary.org/obo/BFO_0000040>)
 SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0000465> <http://purl.obolibrary.org/obo/UBERON_0001062>)
 DisjointClasses(<http://purl.obolibrary.org/obo/UBERON_0000465> <http://purl.obolibrary.org/obo/UBERON_0000466>)
@@ -62635,7 +62762,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0000475> ObjectSomeValuesFrom(
 # Class: <http://purl.obolibrary.org/obo/UBERON_0000476> (acellular anatomical structure)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/UBERON_0000476> "acellular anatomical structure")
-SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0000476> <http://purl.obolibrary.org/obo/UBERON_0000061>)
+SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0000476> <http://purl.obolibrary.org/obo/UBERON_0000001>)
 
 # Class: <http://purl.obolibrary.org/obo/UBERON_0000477> (anatomical cluster)
 
@@ -63400,6 +63527,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0001052> ObjectSomeValuesFrom(
 # Class: <http://purl.obolibrary.org/obo/UBERON_0001062> (anatomical entity)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/UBERON_0001062> "anatomical entity")
+EquivalentClasses(<http://purl.obolibrary.org/obo/UBERON_0001062> ObjectUnionOf(<http://purl.obolibrary.org/obo/UBERON_0000465> <http://purl.obolibrary.org/obo/UBERON_0000466>))
 EquivalentClasses(<http://purl.obolibrary.org/obo/UBERON_0001062> ObjectHasSelf(<http://purl.obolibrary.org/obo/RO_0020105>))
 SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0001062> <http://purl.obolibrary.org/obo/BFO_0000004>)
 
@@ -65137,7 +65265,6 @@ SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0001737> ObjectSomeValuesFrom(
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/UBERON_0001739> "laryngeal cartilage")
 EquivalentClasses(<http://purl.obolibrary.org/obo/UBERON_0001739> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/UBERON_0007844> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0001737>)))
 SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0001739> <http://purl.obolibrary.org/obo/UBERON_0003406>)
-SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0001739> <http://purl.obolibrary.org/obo/UBERON_0007844>)
 SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0001739> <http://purl.obolibrary.org/obo/UBERON_0011004>)
 SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0001739> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0001737>))
 SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0001739> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0008895>))
@@ -65375,7 +65502,6 @@ SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0001803> ObjectSomeValuesFrom(
 AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasExactSynonym> <http://purl.obolibrary.org/obo/UBERON_0001804> "lens capsule")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/UBERON_0001804> "capsule of lens")
 EquivalentClasses(<http://purl.obolibrary.org/obo/UBERON_0001804> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/UBERON_0000476> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002007> <http://purl.obolibrary.org/obo/UBERON_0000965>)))
-SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0001804> <http://purl.obolibrary.org/obo/UBERON_0004121>)
 SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0001804> <http://purl.obolibrary.org/obo/UBERON_0005764>)
 SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0001804> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000965>))
 SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0001804> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> <http://purl.obolibrary.org/obo/CHEBI_35722>))
@@ -66439,7 +66565,6 @@ AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasExactSynony
 AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasExactSynonym> <http://purl.obolibrary.org/obo/UBERON_0002111> "artery smooth muscle tissue")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/UBERON_0002111> "artery smooth muscle tissue")
 EquivalentClasses(<http://purl.obolibrary.org/obo/UBERON_0002111> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/UBERON_0001135> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0001637>)))
-SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0002111> <http://purl.obolibrary.org/obo/UBERON_0001135>)
 SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0002111> <http://purl.obolibrary.org/obo/UBERON_0004237>)
 SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0002111> <http://purl.obolibrary.org/obo/UBERON_0004695>)
 SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0002111> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0001637>))
@@ -67820,7 +67945,6 @@ SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0002871> ObjectSomeValuesFrom(
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/UBERON_0002925> "trigeminal nucleus")
 EquivalentClasses(<http://purl.obolibrary.org/obo/UBERON_0002925> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/UBERON_0002308> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0007641>)))
 SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0002925> <http://purl.obolibrary.org/obo/UBERON_0000126>)
-SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0002925> <http://purl.obolibrary.org/obo/UBERON_0002308>)
 SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0002925> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0007641>))
 SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0002925> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/uberon/core#extends_fibers_into> <http://purl.obolibrary.org/obo/UBERON_0001645>))
 
@@ -70810,6 +70934,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0004367> ObjectSomeValuesFrom(
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/UBERON_0004370> "anterior limiting lamina of cornea")
 EquivalentClasses(<http://purl.obolibrary.org/obo/UBERON_0004370> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/UBERON_0005769> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000964>) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002371> <http://purl.obolibrary.org/obo/UBERON_0001772>)))
+SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0004370> <http://purl.obolibrary.org/obo/UBERON_0000061>)
 SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0004370> <http://purl.obolibrary.org/obo/UBERON_0005769>)
 SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0004370> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/RO_0002577>))
 SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0004370> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000964>))
@@ -72630,7 +72755,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0005421> ObjectSomeValuesFrom(
 # Class: <http://purl.obolibrary.org/obo/UBERON_0005423> (developing anatomical structure)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/UBERON_0005423> "developing anatomical structure")
-SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0005423> <http://purl.obolibrary.org/obo/UBERON_0000465>)
+SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0005423> <http://purl.obolibrary.org/obo/UBERON_0000001>)
 SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0005423> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002215> <http://purl.obolibrary.org/obo/GO_0032502>))
 
 # Class: <http://purl.obolibrary.org/obo/UBERON_0005425> (presumptive neural retina)
@@ -74785,13 +74910,6 @@ SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0007617> <http://purl.obolibra
 SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0007617> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0002217>))
 SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0007617> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002572> <http://purl.obolibrary.org/obo/UBERON_0002217>))
 
-# Class: <http://purl.obolibrary.org/obo/UBERON_0007625> (pigment epithelium of eye)
-
-AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/UBERON_0007625> "pigment epithelium of eye")
-EquivalentClasses(<http://purl.obolibrary.org/obo/UBERON_0007625> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/UBERON_0000483> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000970>)))
-SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0007625> <http://purl.obolibrary.org/obo/UBERON_0019304>)
-SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0007625> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000970>))
-
 # Class: <http://purl.obolibrary.org/obo/UBERON_0007635> (nucleus of medulla oblongata)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/UBERON_0007635> "nucleus of medulla oblongata")
@@ -75483,7 +75601,6 @@ SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0009199> ObjectSomeValuesFrom(
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/UBERON_0009204> "medial nasal process mesenchyme")
 EquivalentClasses(<http://purl.obolibrary.org/obo/UBERON_0009204> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/UBERON_0003104> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0004068>)))
-SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0009204> <http://purl.obolibrary.org/obo/UBERON_0003104>)
 SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0009204> <http://purl.obolibrary.org/obo/UBERON_0009501>)
 SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0009204> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0004068>))
 SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0009204> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002202> <http://purl.obolibrary.org/obo/UBERON_0007213>))
@@ -76414,7 +76531,6 @@ SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0010252> ObjectSomeValuesFrom(
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/UBERON_0010253> "1st arch maxillary mesenchyme from neural crest")
 EquivalentClasses(<http://purl.obolibrary.org/obo/UBERON_0010253> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/UBERON_0003104> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0010045>) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002202> <http://purl.obolibrary.org/obo/UBERON_0002342>)))
-SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0010253> <http://purl.obolibrary.org/obo/UBERON_0003104>)
 SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0010253> <http://purl.obolibrary.org/obo/UBERON_0010045>)
 SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0010253> <http://purl.obolibrary.org/obo/UBERON_0010259>)
 SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0010253> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0010045>))
@@ -76646,7 +76762,6 @@ SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0010333> ObjectSomeValuesFrom(
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/UBERON_0010334> "maxillary process mesenchyme from neural crest")
 EquivalentClasses(<http://purl.obolibrary.org/obo/UBERON_0010334> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/UBERON_0003104> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0009526>) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002202> <http://purl.obolibrary.org/obo/UBERON_0002342>)))
-SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0010334> <http://purl.obolibrary.org/obo/UBERON_0003104>)
 SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0010334> <http://purl.obolibrary.org/obo/UBERON_0009526>)
 SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0010334> <http://purl.obolibrary.org/obo/UBERON_0010258>)
 SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0010334> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0009526>))
@@ -76657,7 +76772,6 @@ SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0010334> ObjectSomeValuesFrom(
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/UBERON_0010335> "maxillary process mesenchyme from head mesenchyme")
 EquivalentClasses(<http://purl.obolibrary.org/obo/UBERON_0010335> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/UBERON_0003104> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0009526>) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002202> <http://purl.obolibrary.org/obo/UBERON_0006904>)))
-SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0010335> <http://purl.obolibrary.org/obo/UBERON_0003104>)
 SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0010335> <http://purl.obolibrary.org/obo/UBERON_0004120>)
 SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0010335> <http://purl.obolibrary.org/obo/UBERON_0009526>)
 SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0010335> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0009526>))
@@ -76668,7 +76782,6 @@ SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0010335> ObjectSomeValuesFrom(
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/UBERON_0010336> "mandibular process mesenchyme from neural crest")
 EquivalentClasses(<http://purl.obolibrary.org/obo/UBERON_0010336> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/UBERON_0003104> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0006905>) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002202> <http://purl.obolibrary.org/obo/UBERON_0002342>)))
-SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0010336> <http://purl.obolibrary.org/obo/UBERON_0003104>)
 SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0010336> <http://purl.obolibrary.org/obo/UBERON_0006905>)
 SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0010336> <http://purl.obolibrary.org/obo/UBERON_0010258>)
 SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0010336> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0006905>))
@@ -76679,7 +76792,6 @@ SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0010336> ObjectSomeValuesFrom(
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/UBERON_0010337> "mandibular process mesenchyme from head mesenchyme")
 EquivalentClasses(<http://purl.obolibrary.org/obo/UBERON_0010337> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/UBERON_0003104> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0006905>) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002202> <http://purl.obolibrary.org/obo/UBERON_0006904>)))
-SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0010337> <http://purl.obolibrary.org/obo/UBERON_0003104>)
 SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0010337> <http://purl.obolibrary.org/obo/UBERON_0006904>)
 SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0010337> <http://purl.obolibrary.org/obo/UBERON_0006905>)
 SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0010337> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0006905>))
@@ -76700,7 +76812,6 @@ SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0010338> ObjectSomeValuesFrom(
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/UBERON_0010339> "1st arch mandibular mesenchyme from head mesenchyme")
 EquivalentClasses(<http://purl.obolibrary.org/obo/UBERON_0010339> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/UBERON_0003104> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0009584>) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002202> <http://purl.obolibrary.org/obo/UBERON_0006904>)))
-SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0010339> <http://purl.obolibrary.org/obo/UBERON_0003104>)
 SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0010339> <http://purl.obolibrary.org/obo/UBERON_0009584>)
 SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0010339> <http://purl.obolibrary.org/obo/UBERON_0010341>)
 SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0010339> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0009584>))
@@ -76710,7 +76821,6 @@ SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0010339> ObjectSomeValuesFrom(
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/UBERON_0010341> "1st arch mesenchyme from head mesenchyme")
 EquivalentClasses(<http://purl.obolibrary.org/obo/UBERON_0010341> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/UBERON_0003104> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0010042>) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002202> <http://purl.obolibrary.org/obo/UBERON_0006904>)))
-SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0010341> <http://purl.obolibrary.org/obo/UBERON_0003104>)
 SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0010341> <http://purl.obolibrary.org/obo/UBERON_0010042>)
 SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0010341> <http://purl.obolibrary.org/obo/UBERON_0010360>)
 SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0010341> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0010042>))
@@ -76918,15 +77028,6 @@ SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0010499> <http://purl.obolibra
 SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0010499> <http://purl.obolibrary.org/obo/UBERON_0010498>)
 SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0010499> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> <http://purl.obolibrary.org/obo/CL_0000067>))
 
-# Class: <http://purl.obolibrary.org/obo/UBERON_0010521> (electroreceptor organ)
-
-AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasExactSynonym> <http://purl.obolibrary.org/obo/UBERON_0010521> "electric sense organ")
-AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasExactSynonym> <http://purl.obolibrary.org/obo/UBERON_0010521> "electroreception organ")
-AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/UBERON_0010521> "electroreceptor organ")
-EquivalentClasses(<http://purl.obolibrary.org/obo/UBERON_0010521> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/UBERON_0000062> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002215> <http://purl.obolibrary.org/obo/GO_0050964>)))
-SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0010521> <http://purl.obolibrary.org/obo/UBERON_0000020>)
-SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0010521> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002215> <http://purl.obolibrary.org/obo/GO_0050964>))
-
 # Class: <http://purl.obolibrary.org/obo/UBERON_0010522> (replacement element)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/UBERON_0010522> "replacement element")
@@ -79021,7 +79122,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0015796> ObjectSomeValuesFrom(
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/UBERON_0015808> "eye epithelium")
 EquivalentClasses(<http://purl.obolibrary.org/obo/UBERON_0015808> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/UBERON_0000483> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000019>)))
-SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0015808> <http://purl.obolibrary.org/obo/UBERON_0007625>)
+SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0015808> <http://purl.obolibrary.org/obo/UBERON_0019304>)
 SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0015808> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000019>))
 
 # Class: <http://purl.obolibrary.org/obo/UBERON_0015833> (foregut epithelium)
@@ -80286,7 +80387,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0036214> ObjectSomeValuesFrom(
 # Class: <http://purl.obolibrary.org/obo/UBERON_0036215> (anatomical surface region)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/UBERON_0036215> "anatomical surface region")
-SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0036215> <http://purl.obolibrary.org/obo/UBERON_0000465>)
+SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0036215> <http://purl.obolibrary.org/obo/UBERON_0000001>)
 SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0036215> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000061>))
 SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0036215> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002007> <http://purl.obolibrary.org/obo/UBERON_0000061>))
 
@@ -80411,7 +80512,6 @@ SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0036303> ObjectSomeValuesFrom(
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/UBERON_0036343> "wall of gallbladder")
 EquivalentClasses(<http://purl.obolibrary.org/obo/UBERON_0036343> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/UBERON_0000060> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0002110>)))
-SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0036343> <http://purl.obolibrary.org/obo/UBERON_0000060>)
 SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0036343> <http://purl.obolibrary.org/obo/UBERON_0003697>)
 SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0036343> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0002110>))
 
@@ -80433,7 +80533,6 @@ SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0036352> ObjectSomeValuesFrom(
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/UBERON_0036362> "wall of anal canal")
 EquivalentClasses(<http://purl.obolibrary.org/obo/UBERON_0036362> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/UBERON_0000060> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000159>) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0001007>)))
-SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0036362> <http://purl.obolibrary.org/obo/UBERON_0000060>)
 SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0036362> <http://purl.obolibrary.org/obo/UBERON_0001169>)
 SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0036362> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000159>))
 SubClassOf(<http://purl.obolibrary.org/obo/UBERON_0036362> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0001007>))
@@ -81026,6 +81125,13 @@ EquivalentClasses(<http://purl.obolibrary.org/obo/UBERON_8600140> ObjectIntersec
 SubClassOf(<http://purl.obolibrary.org/obo/UBERON_8600140> <http://purl.obolibrary.org/obo/UBERON_0011189>)
 SubClassOf(<http://purl.obolibrary.org/obo/UBERON_8600140> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0001052>))
 
+# Class: <http://purl.obolibrary.org/obo/UBERON_8850001> (epithelium of anorectum)
+
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/UBERON_8850001> "epithelium of anorectum")
+EquivalentClasses(<http://purl.obolibrary.org/obo/UBERON_8850001> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/UBERON_0000483> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_8410050>)))
+SubClassOf(<http://purl.obolibrary.org/obo/UBERON_8850001> <http://purl.obolibrary.org/obo/UBERON_0001278>)
+SubClassOf(<http://purl.obolibrary.org/obo/UBERON_8850001> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_8410050>))
+
 
 ############################
 #   Named Individuals