- Identifying genes which influence cortex development.
- Identify the trajectories of cortical glutamatergic neurons throughout corticogenesis (previously unknown/unclear)
- Measuring chromatin accessibility (scATAC-seq)
- More accessible chromatin means that transcription factors (TFs) are more likely to bind, which can lead to gene expression if the right TFs are present and active.
- Measures gene expression using scRNA-seq
- Gene activity score vs gene expression
- Gene activity score is dependent on chromatin accesibility, whereas gene expression is measured by the amount of matching RNA transcribed