diff --git a/CHANGELOG.md b/CHANGELOG.md
index 2533447e73..cf6b986492 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -11,6 +11,7 @@ and this project adheres to [Semantic Versioning](http://semver.org/).
 
 - Fixed issue with the "transparent" CSS value not being transparent when set using python https://github.com/Textualize/textual/pull/5890
 - Fixed issue with pushing screens when Input has mouse captured https://github.com/Textualize/textual/pull/5900
+- Implemented workaround for Ghostty bug which produces negative mouse coordinates https://github.com/Textualize/textual/pull/5926
 
 ## Changed
 
diff --git a/src/textual/_xterm_parser.py b/src/textual/_xterm_parser.py
index ed4163fec6..431a4866e7 100644
--- a/src/textual/_xterm_parser.py
+++ b/src/textual/_xterm_parser.py
@@ -18,7 +18,7 @@
 # to be unsuccessful?
 _MAX_SEQUENCE_SEARCH_THRESHOLD = 32
 
-_re_mouse_event = re.compile("^" + re.escape("\x1b[") + r"(<?[\d;]+[mM]|M...)\Z")
+_re_mouse_event = re.compile("^" + re.escape("\x1b[") + r"(<?[-?\d;]+[mM]|M...)\Z")
 _re_terminal_mode_response = re.compile(
     "^" + re.escape("\x1b[") + r"\?(?P<mode_id>\d+);(?P<setting_parameter>\d)\$y"
 )
@@ -50,7 +50,7 @@
 
 
 class XTermParser(Parser[Message]):
-    _re_sgr_mouse = re.compile(r"\x1b\[<(\d+);(\d+);(\d+)([Mm])")
+    _re_sgr_mouse = re.compile(r"\x1b\[<(-?\d+);(-?\d+);(-?\d+)([Mm])")
 
     def __init__(self, debug: bool = False) -> None:
         self.last_x = 0.0
@@ -78,6 +78,9 @@ def parse_mouse_code(self, code: str) -> Message | None:
             buttons = int(_buttons)
             x = float(int(_x) - 1)
             y = float(int(_y) - 1)
+            if x < 0 or y < 0:
+                # TODO: Workaround for Ghostty erroneous negative coordinate bug
+                return None
             if (
                 self.mouse_pixels
                 and self.terminal_pixel_size is not None