diff --git a/paypal/js/frontend.js b/paypal/js/frontend.js
index 13371c0a8a..e9bd5bcd33 100644
--- a/paypal/js/frontend.js
+++ b/paypal/js/frontend.js
@@ -718,7 +718,12 @@
 				onError,
 				style: frmPayPalVars.style,
 				inputEvents: {
-					onChange: onCardFieldsChange
+					onChange: onCardFieldsChange,
+					onFocus() {
+						// onBlur only triggers if onFocus is defined.
+						// But we don't need to do anything on focus.
+					},
+					onBlur: onCardFieldsBlur
 				}
 			};
 
@@ -749,6 +754,19 @@
 		}
 	}
 
+	/**
+	 * Handle card field blur events.
+	 * This detects autofilled fields that may not trigger onChange.
+	 *
+	 * @param {Object} data The onBlur event data.
+	 */
+	function onCardFieldsBlur( data ) {
+		if ( selectedMethod === 'card' && data.isFormValid ) {
+			cardFieldsValid = true;
+			enableSubmit();
+		}
+	}
+
 	/**
 	 * Render the card number / expiry / CVV fields into the method container.
 	 */