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Encoding: UTF-8
Type: Package
Package: pecotmr
Version: 0.6.2
Date: 2026-02-28
Title: Post-GWAS enrichment, colocalization, TWAS and Mendelian Randomization to integrate molecular QTL and GWAS.
Description: The majority of the statistical models in pecotmr are based on fine-mapped single effects described in Wang G et al (2020) JRSS-B. It also incorporates wrappers to a series of useful TWAS methods as well as utility functions for QTL and GWAS integration.
URL: https://statfungen.github.io/pecotmr, https://github.com/StatFunGen/pecotmr
BugReports: https://github.com/StatFunGen/pecotmr/issues
Authors@R: c(person("Gao Wang",role = c("cre","aut"),
email = "wang.gaow@columbia.edu"),
person("Daniel Nachun", role = "aut",
email = "dnachun@stanford.edu"),
person("StatFunGen Lab", role = "ctb"))
License: MIT + file LICENSE
Imports:
BiocParallel,
Biostrings,
GenomicRanges,
IRanges,
MASS,
Matrix,
Rsamtools,
S4Vectors,
SummarizedExperiment,
coloc,
colocboost,
dplyr,
magrittr,
matrixStats,
methods,
purrr,
quadprog,
readr,
rlang,
stringr,
susieR (>= 0.16.2),
tibble,
tictoc,
tidyr,
vctrs,
vroom
Suggests:
aSPU,
arrow,
BGLR,
bigsnpr,
bigstatsr,
coda,
flashier,
fsusieR,
GBJ,
gdsfmt,
glmnet,
harmonicmeanp,
igraph,
knitr,
L0Learn,
lassosum,
mashr,
mr.mashr,
mvsusieR,
ncvreg,
nnls,
pgenlibr,
plinkQC,
poolr,
qgg,
qvalue,
Rfast,
RcppDPR,
rmarkdown,
robustbase,
rtracklayer,
SNPRelate,
snpStats,
testthat,
VariantAnnotation
Remotes:
stephenslab/fsusieR,
stephenslab/mvsusieR,
stephenslab/susieR,
LinkingTo:
cpp11,
cpp11armadillo
NeedsCompilation: yes
VignetteBuilder: knitr
Config/roxygen2/version: 8.0.0
RoxygenNote: 7.3.3
Collate:
'AllGenerics.R'
'GenotypeHandle.R'
'AllClasses.R'
'AnnotationMatrix.R'
'FineMappingEntry.R'
'tupleSelectors.R'
'GwasFineMappingResult.R'
'H2Estimate.R'
'JointGroup.R'
'LdBlocks.R'
'LdData.R'
'LdStatistic.R'
'LdEigen.R'
'LdScore.R'
'MashPrior.R'
'QtlDataset.R'
'MultiStudyQtlDataset.R'
'QtlFineMappingResult.R'
'SldscData.R'
'TwasWeightsEntry.R'
'causalInferencePipeline.R'
'colocPipeline.R'
'colocboostPipeline.R'
'cpp11.R'
'ctwasPipeline.R'
'deprecated.R'
'exampleData.R'
'fineMappingPipeline.R'
'fineMappingWrappers.R'
'genotypeIo.R'
'gwasSumStats.R'
'h2Annotations.R'
'h2EstimationWrappers.R'
'jointEngine.R'
'jointSpecification.R'
'ld.R'
'mashPipeline.R'
'mashWrapper.R'
'pvalCombine.R'
'qtlEnrichmentPipeline.R'
'qtlSumStats.R'
'regularizedRegressionWrappers.R'
'relatednessQc.R'
'sldscPostprocessingPipeline.R'
'sldscWrapper.R'
'sumstatsQc.R'
'twasWeights.R'
'twasWeightsPipeline.R'
'variantId.R'
'vcfWriter.R'
Depends:
R (>= 3.5)
LazyData: true