diff --git a/pyproject.toml b/pyproject.toml
new file mode 100644
index 0000000..c3edb43
--- /dev/null
+++ b/pyproject.toml
@@ -0,0 +1,40 @@
+[build-system]
+requires = ["hatchling"]
+build-backend = "hatchling.build"
+
+[project]
+name = "primertrim"
+version = "1.1.0.dev1"
+description = "Trim primer sequences from FASTQ files"
+readme = "README.md"
+license = { text = "GPL-2.0-or-later" }
+requires-python = ">=3.10"
+
+authors = [
+  { name = "Kyle Bittinger", email = "kylebittinger@gmail.com" },
+]
+
+classifiers = [
+    "Intended Audience :: Science/Research",
+    "License :: OSI Approved :: GNU General Public License v2 or later (GPLv2+)",
+    "Operating System :: POSIX :: Linux",
+    "Operating System :: MacOS :: MacOS X",
+    "Programming Language :: Python :: 3",
+    "Topic :: Scientific/Engineering :: Bio-Informatics",
+]
+
+dependencies = [
+]
+
+[project.optional-dependencies]
+dev = [
+    "pytest",
+    "pytest-cov",
+    "black",
+]
+
+[project.urls]
+Homepage = "https://github.com/PennChopMicrobiomeProgram/primertrim"
+
+[project.scripts]
+ptrim = "primertrim.command:main"
diff --git a/setup.py b/setup.py
deleted file mode 100644
index b006efb..0000000
--- a/setup.py
+++ /dev/null
@@ -1,16 +0,0 @@
-from setuptools import setup
-
-setup(
-    name="primertrim",
-    version="0.0.3",
-    description="Trim primer sequences from FASTQ files",
-    author="PennCHOP Microbiome Program",
-    author_email="BITTINGERK@chop.edu",
-    url="https://github.com/PennChopMicrobiomeProgram/primertrim",
-    packages=["primertrim"],
-    entry_points={
-        "console_scripts": [
-            "ptrim=primertrim.command:main",
-        ],
-    },
-)