diff --git a/pkgs/development/python-modules/setuptools-rust/default.nix b/pkgs/development/python-modules/setuptools-rust/default.nix
index 8f340085ca07d..48efa6f79ba89 100644
--- a/pkgs/development/python-modules/setuptools-rust/default.nix
+++ b/pkgs/development/python-modules/setuptools-rust/default.nix
@@ -43,11 +43,16 @@ buildPythonPackage rec {
   # integrate the setup hook to set up the build environment for cross compilation
   # this hook is automatically propagated to consumers using setuptools-rust as build-system
   #
-  # Only include the setup hook if python.pythonOnTargetForTarget is not empty.
+  # No need for the setup hook when python.pythonOnTargetForTarget is empty,
+  # or when the host & target platforms are the same.
+  #
   # python.pythonOnTargetForTarget is not always available, for example in
   # pkgsLLVM.python3.pythonOnTargetForTarget. cross build with pkgsLLVM should not be affected.
   setupHook =
-    if python.pythonOnTargetForTarget == { } then
+    if
+      python.pythonOnTargetForTarget == { }
+      || (lib.systems.equals stdenv.hostPlatform stdenv.targetPlatform)
+    then
       null
     else
       replaceVars ./setuptools-rust-hook.sh {