diff --git a/pkgs/by-name/ce/ceph/old-python-packages/cryptography.nix b/pkgs/by-name/ce/ceph/old-python-packages/cryptography.nix
index f10d285617a78..f6129b7c05547 100644
--- a/pkgs/by-name/ce/ceph/old-python-packages/cryptography.nix
+++ b/pkgs/by-name/ce/ceph/old-python-packages/cryptography.nix
@@ -9,7 +9,7 @@
   rustPlatform,
   cargo,
   rustc,
-  setuptoolsRustBuildHook,
+  setuptools-rust,
   openssl,
   Security ? null,
   isPyPy,
@@ -74,9 +74,12 @@ buildPythonPackage rec {
 
   cargoRoot = "src/rust";
 
+  build-system = [
+    setuptools-rust
+  ];
+
   nativeBuildInputs = [
     rustPlatform.cargoSetupHook
-    setuptoolsRustBuildHook
     cargo
     rustc
     pkg-config
diff --git a/pkgs/development/interpreters/python/hooks/default.nix b/pkgs/development/interpreters/python/hooks/default.nix
index b3c97de303179..602030cae5e3c 100644
--- a/pkgs/development/interpreters/python/hooks/default.nix
+++ b/pkgs/development/interpreters/python/hooks/default.nix
@@ -441,20 +441,6 @@ in
     } ./setuptools-build-hook.sh
   ) { };
 
-  setuptoolsRustBuildHook = callPackage (
-    { makePythonHook, setuptools-rust }:
-    makePythonHook {
-      name = "setuptools-rust-setup-hook";
-      propagatedBuildInputs = [ setuptools-rust ];
-      substitutions = {
-        pyLibDir = "${python}/lib/${python.libPrefix}";
-        cargoBuildTarget = stdenv.hostPlatform.rust.rustcTargetSpec;
-        cargoLinkerVar = stdenv.hostPlatform.rust.cargoEnvVarTarget;
-        targetLinker = "${stdenv.cc}/bin/${stdenv.cc.targetPrefix}cc";
-      };
-    } ./setuptools-rust-hook.sh
-  ) { };
-
   unittestCheckHook = callPackage (
     { makePythonHook }:
     makePythonHook {
diff --git a/pkgs/development/python-modules/setuptools-rust/default.nix b/pkgs/development/python-modules/setuptools-rust/default.nix
index 087e5026c33b7..3e7dd96253f07 100644
--- a/pkgs/development/python-modules/setuptools-rust/default.nix
+++ b/pkgs/development/python-modules/setuptools-rust/default.nix
@@ -1,5 +1,6 @@
 {
   lib,
+  stdenv,
   buildPythonPackage,
   fetchPypi,
   maturin,
@@ -11,8 +12,9 @@
   setuptools,
   setuptools-rust,
   setuptools-scm,
+  replaceVars,
+  targetPackages,
 }:
-
 buildPythonPackage rec {
   pname = "setuptools-rust";
   version = "1.12.0";
@@ -40,6 +42,23 @@ buildPythonPackage rec {
 
   doCheck = false;
 
+  # integrate the setup hook to set up the build environment for cross compilation
+  # this hook is automatically propagated to consumers using setuptools-rust as build-system
+  #
+  # Only include the setup hook if targetPackages.python3 is defined.
+  # targetPackages.python3 is not always available, for example when including
+  # setuptools-rust via buildInputs instead of nativeBuildInputs or building it directly.
+  setupHook =
+    if !(targetPackages ? python3) then
+      null
+    else
+      replaceVars ./setuptools-rust-hook.sh {
+        pyLibDir = "${targetPackages.python3}/lib/${targetPackages.python3.libPrefix}";
+        cargoBuildTarget = stdenv.targetPlatform.rust.rustcTargetSpec;
+        cargoLinkerVar = stdenv.targetPlatform.rust.cargoEnvVarTarget;
+        targetLinker = "${targetPackages.stdenv.cc}/bin/${targetPackages.stdenv.cc.targetPrefix}cc";
+      };
+
   passthru.tests = {
     pyo3 = maturin.tests.pyo3.override {
       format = "setuptools";
diff --git a/pkgs/development/interpreters/python/hooks/setuptools-rust-hook.sh b/pkgs/development/python-modules/setuptools-rust/setuptools-rust-hook.sh
similarity index 100%
rename from pkgs/development/interpreters/python/hooks/setuptools-rust-hook.sh
rename to pkgs/development/python-modules/setuptools-rust/setuptools-rust-hook.sh
diff --git a/pkgs/top-level/python-aliases.nix b/pkgs/top-level/python-aliases.nix
index 321d01c9ba128..c0afe1d97df40 100644
--- a/pkgs/top-level/python-aliases.nix
+++ b/pkgs/top-level/python-aliases.nix
@@ -437,6 +437,7 @@ mapAliases {
   sentry-sdk_2 = throw "'sentry-sdk_2' has been renamed to/replaced by 'sentry-sdk'"; # Converted to throw 2025-10-29
   setuptools_dso = throw "'setuptools_dso' has been renamed to/replaced by 'setuptools-dso'"; # Converted to throw 2025-10-29
   setuptools_scm = throw "'setuptools_scm' has been renamed to/replaced by 'setuptools-scm'"; # Converted to throw 2025-10-29
+  setuptoolsRustBuildHook = lib.warn "setuptoolsRustBuildHook is deprecated. Instead, include 'setuptools-rust' via 'build-system'" setuptools-rust; # added 2025-12-07
   setuptoolsTrial = throw "'setuptoolsTrial' has been renamed to/replaced by 'setuptools-trial'"; # Converted to throw 2025-10-29
   sharkiqpy = throw "'sharkiqpy' has been renamed to/replaced by 'sharkiq'"; # Converted to throw 2025-10-29
   shippai = throw "shippai has been removed because the upstream repository was archived in 2023"; # added 2025-07-09