diff --git a/BUILD_OPTIONS.md b/BUILD_OPTIONS.md
index 88fe52e6fb..6fc62a5b64 100644
--- a/BUILD_OPTIONS.md
+++ b/BUILD_OPTIONS.md
@@ -51,18 +51,18 @@ For a more complete list of cmake variables, take a look in the file `CMakeCache
 -DEIGEN3_INCLUDE_DIR=your/path/to/eigen
 
 
-# Set the Python executable: PYTHON_EXECUTABLE
+# Set the Python executable: Python3_EXECUTABLE
 # If working from a virtual environment, cmake will automatically set this as
 # the executable in the environment's directory. It may, however, have trouble
 # finding the system Python library and include directory of the same version, so
-# setting PYTHON_LIBRARY and PYTHON_INCLUDE_DIR manually is encouraged.
--DPYTHON_EXECUTABLE=/usr/bin/python3
+# setting Python3_LIBRARY and Python3_INCLUDE_DIR manually is encouraged.
+-DPython3_EXECUTABLE=/usr/bin/python3
 
-# Set the Python include directory: PYTHON_INCLUDE_DIR
--DPYTHON_INCLUDE_DIR=/usr/include/python3.7m
+# Set the Python include directory: Python3_INCLUDE_DIR
+-DPython3_INCLUDE_DIR=/usr/include/python3.10
 
-# Set the Python library: PYTHON_LIBRARY
--DPYTHON_LIBRARY=/usr/lib/x86_64-linux-gnu/libpython3.7m.so
+# Set the Python library: Python3_LIBRARY
+-DPython3_LIBRARY=/usr/lib/x86_64-linux-gnu/libpython3.10.so
 
 
 # Switch HepMC on/off: WITH_HEPMC (On|Off)
diff --git a/README_OSX.md b/README_OSX.md
index 6a860649cd..1c092b3dcd 100644
--- a/README_OSX.md
+++ b/README_OSX.md
@@ -71,7 +71,7 @@ Configure GAMBIT.  Key optional extras:
   `-D WITH_MPI=ON` if you want scanners to be parallelised
   `-D WITH_HEPMC=ON` if you want HepMC enabled
 ```
-cmake -D PYTHON_EXECUTABLE=/usr/bin/python3 -D PYTHON_LIBRARY=/Library/Developer/CommandLineTools/Library/Frameworks/Python3.framework/Versions/Current/Python3 -D PYTHON_INCLUDE_DIR=/Library/Developer/CommandLineTools/Library/Frameworks/Python3.framework/Headers ..
+cmake -D Python3_EXECUTABLE=/usr/bin/python3 -D Python3_LIBRARY=/Library/Developer/CommandLineTools/Library/Frameworks/Python3.framework/Versions/Current/Python3 -D Python3_INCLUDE_DIR=/Library/Developer/CommandLineTools/Library/Frameworks/Python3.framework/Headers ..
 ```
 
 Now, see the instructions in the main README.md for possible make targets, and BUILD_OPTIONS.md for other cmake options.
diff --git a/ScannerBit/python/CMakeLists.txt b/ScannerBit/python/CMakeLists.txt
index fd7839e1f7..5d73829db6 100644
--- a/ScannerBit/python/CMakeLists.txt
+++ b/ScannerBit/python/CMakeLists.txt
@@ -20,7 +20,7 @@ if(Python3_Interpreter_FOUND)
     ################## ScannerBit_python_interface ##################
     
     set(scan_module_libraries
-        #${PYTHON_LIBRARIES}
+        #${Python3_LIBRARIES}
         yaml-cpp
         ${OpenMP_omp_LIBRARY}
     )
diff --git a/ScannerBit/python/cmake/scannerbit_python_interface_utils.cmake b/ScannerBit/python/cmake/scannerbit_python_interface_utils.cmake
index 087c27b5b4..43b0384987 100644
--- a/ScannerBit/python/cmake/scannerbit_python_interface_utils.cmake
+++ b/ScannerBit/python/cmake/scannerbit_python_interface_utils.cmake
@@ -40,7 +40,7 @@ function(add_gambit_deps obj_name)
         target_link_libraries(${obj_name} ${Mathematica_WSTP_LIBRARIES})
     endif()
     #if(pybind11_FOUND)
-    #    target_link_libraries(${obj_name} ${PYTHON_LIBRARIES})
+    #    target_link_libraries(${obj_name} ${Python3_LIBRARIES})
     #endif()
     if(SQLITE3_FOUND)
         target_link_libraries(${obj_name} ${SQLITE3_LIBRARIES})
diff --git a/ScannerBit/scripts/scanner+_harvester.py b/ScannerBit/scripts/scanner+_harvester.py
index 753411897b..418498ab4d 100644
--- a/ScannerBit/scripts/scanner+_harvester.py
+++ b/ScannerBit/scripts/scanner+_harvester.py
@@ -459,7 +459,7 @@ def main(argv):
                                                     inc_commands += [incdir]
                                                     scanbit_reqs[plugin[7]][plugin_name][version][5] += [incdir]
                                                     inc_files += [[inc, incdir]]
-                                                elif inc == "ROOT" or inc == "GSL" or inc == "pybind11" or inc == "Python" or inc == "PYTHONLIBS":
+                                                elif inc == "ROOT" or inc == "GSL" or inc == "pybind11" or inc == "Python3":
                                                     auto_incs += [inc]
                                                     #scanbit_reqs[plugin[7]][plugin_name][version][5] += [inc]
                                                     if scanbit_reqs[plugin[7]][plugin_name][version][2] == "":
@@ -840,7 +840,7 @@ def main(argv):
 
                     temp = set(inc for inc in scanbit_auto_incs[plug_type[i]][directory])
                     for inc in temp:
-                        if inc == "ROOT" or inc == "Python":
+                        if inc == "ROOT" or inc == "Python3":
                             towrite += """
 if ({2}_FOUND)
     set ({0}_plugin_includes_{1}
@@ -867,19 +867,6 @@ def main(argv):
     set ({0}_ok_flag_{1} \"${{{0}_ok_flag_{1}}} \\n    - file missing: \\\"{2}\\\"\")
 endif()
 """.format(plug_type[i], directory, inc, "PYBIND11")
-                        elif inc == "PYTHONLIBS":
-                            towrite += """
-if ({2}_FOUND)
-    set ({0}_plugin_includes_{1}
-        ${{{0}_plugin_includes_{1}}}
-        ${{{3}_INCLUDE_DIRS}}
-    )
-    set ({0}_plugin_found_incs_{1} \"${{{0}_plugin_found_incs_{1}}}    \\\"{2}\\\": ${{{3}_INCLUDE_DIRS}}\\n\")
-else()
-    message(\"-- Did not find {0} header {2}. Disabling scanners that depend on this.\")
-    set ({0}_ok_flag_{1} \"${{{0}_ok_flag_{1}}} \\n    - file missing: \\\"{2}\\\"\")
-endif()
-""".format(plug_type[i], directory, inc, "PYTHON")
                         else:
                             towrite += """
 unset({0}_{1}_{3}_INCLUDE_PATH CACHE)
diff --git a/ScannerBit/src/objectives/python/python.cpp b/ScannerBit/src/objectives/python/python.cpp
index 076859af9a..72abe457cb 100644
--- a/ScannerBit/src/objectives/python/python.cpp
+++ b/ScannerBit/src/objectives/python/python.cpp
@@ -65,7 +65,7 @@ namespace Gambit
 objective_plugin(python, version(1, 0, 0))
 {
     
-    reqd_headers("PYTHONLIBS");
+    reqd_headers("Python3");
     reqd_headers("pybind11");
     
     Gambit::Utils::python_interpreter_guard g;
diff --git a/ScannerBit/src/scanners/python/python.cpp b/ScannerBit/src/scanners/python/python.cpp
index 31c9341596..a875ca7456 100644
--- a/ScannerBit/src/scanners/python/python.cpp
+++ b/ScannerBit/src/scanners/python/python.cpp
@@ -76,7 +76,7 @@ namespace Gambit
 scanner_plugin(python, version(1, 0, 0))
 {
     
-    reqd_headers("PYTHONLIBS");
+    reqd_headers("Python3");
     reqd_headers("pybind11");
 
     Gambit::Utils::python_interpreter_guard g;
diff --git a/gum/gum b/gum/gum
index 2feb508ace..4dba04268c 100755
--- a/gum/gum
+++ b/gum/gum
@@ -23,7 +23,7 @@ if [ -f ${cmake_variables_file} ]
 then
 
   # Extract location of python executable
-  python_exec=`awk -F\" '/^PYTHON_EXECUTABLE/{print $2}' ${cmake_variables_file}`
+  python_exec=`awk -F\" '/^Python3_EXECUTABLE/{print $2}' ${cmake_variables_file}`
 
   # If the variable does not appear on the cmake_variable file, something went wrong
   if [ -z ${python_exec} ]
diff --git a/gum/src/cmake_variables.py.in b/gum/src/cmake_variables.py.in
index 5feceee26d..9141a5f2fc 100644
--- a/gum/src/cmake_variables.py.in
+++ b/gum/src/cmake_variables.py.in
@@ -20,7 +20,7 @@
 GUM_DIR = "@GUM_DIR@"
 
 # Python executable
-PYTHON_EXECUTABLE = "@PYTHON_EXECUTABLE@"
+Python3_EXECUTABLE = "@Python3_EXECUTABLE@"
 
 # Pythia version (No longer a constant)
 # base_pythia_version = "@BASE_PYTHIA_VERSION@"
diff --git a/gum/src/pythia.py b/gum/src/pythia.py
index 2d8cec166c..170427b7b7 100644
--- a/gum/src/pythia.py
+++ b/gum/src/pythia.py
@@ -407,7 +407,7 @@ def write_pythia_cmake_entry(model, output_dir, base_pythia_version):
                "    BUILD_IN_SOURCE 1\n"\
                "    PATCH_COMMAND patch -p1 < ${model_specific_patch}\n"\
                "          COMMAND patch -p1 < ${patch}\n"\
-               "          COMMAND ${PYTHON_EXECUTABLE} ${PROJECT_SOURCE_DIR}/Backends/patches/${name}/${ver}/patch_${name}.py\n"\
+               "          COMMAND ${Python3_EXECUTABLE} ${PROJECT_SOURCE_DIR}/Backends/patches/${name}/${ver}/patch_${name}.py\n"\
                "    CONFIGURE_COMMAND ./configure ${EXTRA_CONFIG} --enable-shared --cxx=\"${CMAKE_CXX_COMPILER}\" --cxx-common=\"${pythia_CXXFLAGS}\" --cxx-shared=\"${pythia_CXX_SHARED_FLAGS}\" --cxx-soname=\"${pythia_CXX_SONAME_FLAGS}\" --lib-suffix=\".so\"\n"\
                "    BUILD_COMMAND ${CMAKE_MAKE_PROGRAM} CXX=\"${CMAKE_CXX_COMPILER}\" lib/${lib}.so\n"\
                "    INSTALL_COMMAND \"\"\n"\